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Aliases for STAC2 Gene

Aliases for STAC2 Gene

  • SH3 And Cysteine Rich Domain 2 2 3 5
  • 24b2/STAC2 3 4
  • SRC Homology 3 And Cysteine-Rich Domain-Containing Protein 2 3
  • Src Homology 3 And Cysteine-Rich Domain-Containing Protein 2 4
  • 24b2 3

External Ids for STAC2 Gene

Previous GeneCards Identifiers for STAC2 Gene

  • GC17M037741
  • GC17M034620
  • GC17M037368
  • GC17M033161

Summaries for STAC2 Gene

GeneCards Summary for STAC2 Gene

STAC2 (SH3 And Cysteine Rich Domain 2) is a Protein Coding gene. An important paralog of this gene is STAC.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAC2 Gene

Genomics for STAC2 Gene

Regulatory Elements for STAC2 Gene

Enhancers for STAC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STAC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for STAC2 Gene

39,210,536 bp from pter
39,225,872 bp from pter
15,337 bases
Minus strand

Genomic View for STAC2 Gene

Genes around STAC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAC2 Gene

Proteins for STAC2 Gene

  • Protein details for STAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH3 and cysteine-rich domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q32MA3

    Protein attributes for STAC2 Gene

    411 amino acids
    Molecular mass:
    45009 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STAC2 Gene


neXtProt entry for STAC2 Gene

Proteomics data for STAC2 Gene at MOPED

Post-translational modifications for STAC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STAC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STAC2 Gene

Domains & Families for STAC2 Gene

Protein Domains for STAC2 Gene


Suggested Antigen Peptide Sequences for STAC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH3 domain.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
  • Contains 1 SH3 domain.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with STAC2: view

No data available for Gene Families for STAC2 Gene

Function for STAC2 Gene

genes like me logo Genes that share phenotypes with STAC2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STAC2 Gene

Localization for STAC2 Gene

Subcellular locations from

Jensen Localization Image for STAC2 Gene COMPARTMENTS Subcellular localization image for STAC2 gene
Compartment Confidence
cytosol 3
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for STAC2 Gene

Pathways & Interactions for STAC2 Gene

SuperPathways for STAC2 Gene

No Data Available

Interacting Proteins for STAC2 Gene

Gene Ontology (GO) - Biological Process for STAC2 Gene


No data available for Pathways by source and SIGNOR curated interactions for STAC2 Gene

Drugs & Compounds for STAC2 Gene

(3) Additional Compounds for STAC2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with STAC2: view

Transcripts for STAC2 Gene

mRNA/cDNA for STAC2 Gene

Unigene Clusters for STAC2 Gene

SH3 and cysteine rich domain 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STAC2 Gene

No ASD Table

Relevant External Links for STAC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STAC2 Gene

mRNA expression in normal human tissues for STAC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STAC2 Gene

This gene is overexpressed in Artery - Tibial (x7.9), Breast - Mammary Tissue (x5.8), Skin - Sun Exposed (Lower leg) (x4.6), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for STAC2 Gene

This gene is overexpressed in Retina (54.0) and Frontal cortex (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STAC2 Gene

SOURCE GeneReport for Unigene cluster for STAC2 Gene Hs.145068

genes like me logo Genes that share expression patterns with STAC2: view

Protein tissue co-expression partners for STAC2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for STAC2 Gene

Orthologs for STAC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for STAC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia STAC2 35
  • 90.93 (n)
  • 94.36 (a)
STAC2 36
  • 92 (a)
(Canis familiaris)
Mammalia STAC2 35
  • 90.93 (n)
  • 94.36 (a)
STAC2 36
  • 94 (a)
(Mus musculus)
Mammalia Stac2 35
  • 89.46 (n)
  • 94.12 (a)
Stac2 16
Stac2 36
  • 94 (a)
(Pan troglodytes)
Mammalia STAC2 35
  • 93.15 (n)
  • 91.21 (a)
STAC2 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Stac2 35
  • 88.89 (n)
  • 93.04 (a)
(Monodelphis domestica)
Mammalia STAC2 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia STAC2 36
  • 84 (a)
(Anolis carolinensis)
Reptilia STAC2 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stac2 35
  • 63.26 (n)
  • 65.34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43729 36
  • 6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
Species with no ortholog for STAC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for STAC2 Gene

Gene Tree for STAC2 (if available)
Gene Tree for STAC2 (if available)

Paralogs for STAC2 Gene

Paralogs for STAC2 Gene

(6) SIMAP similar genes for STAC2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with STAC2: view

Variants for STAC2 Gene

Sequence variations from dbSNP and Humsavar for STAC2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs16542 -- 39,210,176(+) GGTGG(A/G)CAAGA downstream-variant-500B
rs16543 -- 39,210,230(+) CGCGA(C/T)TCAGG downstream-variant-500B
rs16544 -- 39,210,693(+) TGAGA(C/T)CCCGC utr-variant-3-prime
rs16545 -- 39,212,161(+) GCCAC(A/G)GTAAG utr-variant-3-prime
rs16546 -- 39,212,289(+) GGCTC(C/T)TCTCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for STAC2 Gene

Variant ID Type Subtype PubMed ID
nsv833441 CNV Loss 17160897
nsv908203 CNV Loss 21882294
nsv908204 CNV Gain 21882294

Variation tolerance for STAC2 Gene

Residual Variation Intolerance Score: 24.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STAC2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAC2 Gene

Disorders for STAC2 Gene

Relevant External Links for STAC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for STAC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STAC2 Gene

Publications for STAC2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. (PMID: 25184681) Hill S.J. … Livingston D.M. (Genes Dev. 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass A.L. … Elledge S.J. (Science 2008) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for STAC2 Gene

Sources for STAC2 Gene