STAC2 Gene
protein-coding GIFtS: 48
GCID: GC17M037368
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|
SH3 and cysteine rich domain 2
| |
Aliases
for STAC2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SH3 And Cysteine Rich Domain 21 2 | | 24b21 2 | | Src Homology 3 And Cysteine-Rich Domain-Containing Protein 22 3 | | 24b2/STAC22 3 | | SH3 And Cysteine-Rich Domain-Containing Protein 22 |
Export aliases for STAC2 gene to outside databasesPrevious GC identifers: GC17M037741 GC17M034620 GC17M033161 |
Summaries
for STAC2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for STAC2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STAC2 gene promoter:
AhR Max1 NF-1 Pax-5 Pbx1a LCR-F1 Arnt AREB6 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for STAC2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAC2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q21.2STAC2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M037368: view genomic region
(about GC identifiers)
Start:
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37,366,789 bp from pter |
End:
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37,382,125 bp from pter |
Size:
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15,337 bases |
Orientation:
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minus strand |
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Proteins
for STAC2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STAC2_HUMAN, Q6ZMT1 (See
protein sequence)Recommended Name: SH3 and cysteine-rich domain-containing protein 2 Size: 411 amino acids; 45009 Da
Secondary accessions: Q32MA3Alternative splicing: 2 isoforms: Q6ZMT1-1 Q6ZMT1-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for STAC2: NX_Q6ZMT1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZMT1
STAC2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_945344.1
ENSEMBL proteins: ENSP00000327509 ENSP00000463299
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
-- | -- |
STAC2 for ontologies About GeneDecksing
STAC2 Antibody Products:
Assay Products for STAC2: |
Protein
Domains /
Families
for STAC2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STAC2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6ZMT1ProtoNet protein and cluster: Q6ZMT1 1 Blocks protein family: IPB001452 SH3 domain signature
UniProtKB/Swiss-Prot: STAC2_HUMAN, Q6ZMT1Similarity: Contains 1 phorbol-ester/DAG-type zinc fingerSimilarity: Contains 1 SH3 domain |
Function
for STAC2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAC2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAC2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: STAC2 (NM_198993) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STAC2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAC2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAC2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0046872 | metal ion binding |
IEA | -- |
STAC2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for STAC2:
|
Pathways & Interactions
for STAC2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STAC2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for STAC2 (Q6ZMT12, 3 ENSP000003275094) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0035556 | intracellular signal transduction |
IEA | -- |
STAC2 for ontologies About GeneDecksing
|
Drugs & Compounds
for STAC2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for STAC2
10/843 HMDB Compounds for STAC2 (see all 843) About this table
Search CenterWatch for drugs/clinical trials and news about STAC2
|
Transcripts
for STAC2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STAC2 gene: NM_198993.3 Unigene Cluster for STAC2: SH3 and cysteine rich domain 2 Hs.145068 [show with all ESTs]Unigene Representative Sequence: NM_1989932 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000333461(uc002hrs.3 uc010cvt.3) ENST00000584501
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAC2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAC2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: STAC2 (NM_198993) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STAC2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAC2 |
Additional cDNA sequence: AJ608762.1 AK131500.1 AL049460.1 AM903073.1 BC109231.2 1 DOTS entry: DT.40256830 24/51 AceView cDNA sequences (see all 51): AW291623 AK131500 BQ638730 BF724638 AI479848 BU738832 BE859005 AL049460 AJ608762 BG152386 BQ772399 BQ636903 NM_198993 AI890971 AI821472 BQ185187 BM925439 BQ637123 BM676474 BM683839 BM726721 BM713775 BM726017 BX096882
GeneLoc Exon Structure
|
Expression
for STAC2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STAC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGGGTCTGG
About this image
See STAC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STAC2
SOURCE GeneReport for Unigene cluster: Hs.145068
SABiosciences Custom PCR Arrays for STAC2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STAC2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STAC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAC2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAC2 |
Orthologs
for STAC2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for STAC2 gene from 2/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
STAC26 |
-- |
69(a) |
1 ↔ 1 |
6(67440308-67464275) |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
13(a) |
1 → many |
Group8.23(128959-130852) |
ENSEMBL Gene Tree for STAC2 (if available)
TreeFam Gene Tree for STAC2 (if available) |
Paralogs
for STAC2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STAC2 gene
- STAC2 STAC32
6 SIMAP similar genes for STAC2 using alignment to 3 protein entries: STAC2_HUMAN (see all proteins):NCK2 SH3GL2 STAC SH3GL1 ITSN1 STAC3
STAC2 for paralogs About GeneDecksing
|
Genomic Variants
for STAC2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STAC2 (37366789 - 37382125 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for STAC2
1 CNV: 5006 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STAC2 |
|
Disorders
/ Diseases
for STAC2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STAC2 for disorders About GeneDecksing
1  disease for STAC2: About MalaCardsataxia
Human Genome Epidemiology (HuGE) Navigator: STAC2 (1 document)
Export disorders for STAC2 gene to outside databases
|
Publications
for STAC2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STAC2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with STAC2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for STAC2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing STAC2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STAC2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STAC2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for STAC2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for STAC2 gene:
Search GeneIP for patents involving STAC2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for STAC2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for STAC2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STAC2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STAC2 | | | OriGene Protein Over-expression Lysate for STAC2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for STAC2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAC2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAC2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STAC2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STAC2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAC2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAC2 |
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 |  |  |  | |
| | | | Search Tocris compounds for STAC2 |
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 | | | STAC2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAC2 |
|  |  |  | | | | Search ThermoFisher Antibodies for STAC2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAC2 |
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