Free for academic non-profit institutions. Other users need a Commercial license

Aliases for STAC2 Gene

Aliases for STAC2 Gene

  • SH3 And Cysteine Rich Domain 2 2 3
  • 24b2/STAC2 3 4
  • SRC Homology 3 And Cysteine-Rich Domain-Containing Protein 2 3
  • Src Homology 3 And Cysteine-Rich Domain-Containing Protein 2 4
  • SH3 And Cysteine-Rich Domain-Containing Protein 2 3
  • 24b2 3

External Ids for STAC2 Gene

Previous GeneCards Identifiers for STAC2 Gene

  • GC17M037741
  • GC17M034620
  • GC17M037368
  • GC17M033161

Summaries for STAC2 Gene

GeneCards Summary for STAC2 Gene

STAC2 (SH3 And Cysteine Rich Domain 2) is a Protein Coding gene. An important paralog of this gene is STAC.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAC2 Gene

Genomics for STAC2 Gene

Regulatory Elements for STAC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STAC2 Gene

Start:
39,210,536 bp from pter
End:
39,225,872 bp from pter
Size:
15,337 bases
Orientation:
Minus strand

Genomic View for STAC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAC2 Gene

Proteins for STAC2 Gene

  • Protein details for STAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMT1-STAC2_HUMAN
    Recommended name:
    SH3 and cysteine-rich domain-containing protein 2
    Protein Accession:
    Q6ZMT1
    Secondary Accessions:
    • Q32MA3

    Protein attributes for STAC2 Gene

    Size:
    411 amino acids
    Molecular mass:
    45009 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STAC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAC2 Gene

Proteomics data for STAC2 Gene at MOPED

Post-translational modifications for STAC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STAC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STAC2 Gene

Domains for STAC2 Gene

Protein Domains for STAC2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for STAC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZMT1

UniProtKB/Swiss-Prot:

STAC2_HUMAN :
  • Q6ZMT1
Domain:
  • Contains 1 SH3 domain.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with STAC2: view

No data available for Gene Families for STAC2 Gene

Function for STAC2 Gene

Gene Ontology (GO) - Molecular Function for STAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with STAC2: view

Phenotypes for STAC2 Gene

GenomeRNAi human phenotypes for STAC2:
genes like me logo Genes that share phenotypes with STAC2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STAC2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for STAC2 Gene

Localization for STAC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAC2 Gene COMPARTMENTS Subcellular localization image for STAC2 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for STAC2 Gene

Pathways for STAC2 Gene

SuperPathways for STAC2 Gene

No Data Available

Interacting Proteins for STAC2 Gene

Gene Ontology (GO) - Biological Process for STAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with STAC2: view

No data available for Pathways by source for STAC2 Gene

Compounds for STAC2 Gene

(843) HMDB Compounds for STAC2 Gene

Compound Synonyms Cas Number PubMed IDs
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
DG(14:0/16:0/0:0)
  • DAG(30:0)
Not Available
DG(14:0/16:1(9Z)/0:0)
  • DG(30:1)
Not Available
genes like me logo Genes that share compounds with STAC2: view

Transcripts for STAC2 Gene

mRNA/cDNA for STAC2 Gene

Unigene Clusters for STAC2 Gene

SH3 and cysteine rich domain 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STAC2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for STAC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STAC2 Gene

No ASD Table

Relevant External Links for STAC2 Gene

GeneLoc Exon Structure for
STAC2
ECgene alternative splicing isoforms for
STAC2

Expression for STAC2 Gene

mRNA expression in normal human tissues for STAC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STAC2 Gene

This gene is overexpressed in Artery - Tibial (7.9), Breast - Mammary Tissue (5.8), Skin - Sun Exposed (Lower leg) (4.6), and Brain - Cortex (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for STAC2 Gene

SOURCE GeneReport for Unigene cluster for STAC2 Gene Hs.145068

genes like me logo Genes that share expressions with STAC2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for STAC2 Gene

Orthologs for STAC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for STAC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STAC2 35
  • 93.15 (n)
  • 91.21 (a)
STAC2 36
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STAC2 35
  • 90.93 (n)
  • 94.36 (a)
STAC2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STAC2 35
  • 90.93 (n)
  • 94.36 (a)
STAC2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stac2 35
  • 89.46 (n)
  • 94.12 (a)
Stac2 16
Stac2 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STAC2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STAC2 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stac2 35
  • 88.89 (n)
  • 93.04 (a)
lizard
(Anolis carolinensis)
Reptilia STAC2 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stac2 35
  • 63.26 (n)
  • 65.34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43729 36
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
OneToMany
Species with no ortholog for STAC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for STAC2 Gene

ENSEMBL:
Gene Tree for STAC2 (if available)
TreeFam:
Gene Tree for STAC2 (if available)

Paralogs for STAC2 Gene

Paralogs for STAC2 Gene

Selected SIMAP similar genes for STAC2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with STAC2: view

Variants for STAC2 Gene

Sequence variations from dbSNP and Humsavar for STAC2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs16542 -- 39,210,176(+) GGTGG(A/G)CAAGA downstream-variant-500B
rs16543 -- 39,210,230(+) CGCGA(C/T)TCAGG downstream-variant-500B
rs16544 -- 39,210,693(+) TGAGA(C/T)CCCGC utr-variant-3-prime
rs16545 -- 39,212,161(+) GCCAC(A/G)GTAAG utr-variant-3-prime
rs16546 -- 39,212,289(+) GGCTC(C/T)TCTCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for STAC2 Gene

Variant ID Type Subtype PubMed ID
nsv833441 CNV Loss 17160897
nsv908203 CNV Loss 21882294
nsv908204 CNV Gain 21882294

Relevant External Links for STAC2 Gene

HapMap Linkage Disequilibrium report
STAC2
Human Gene Mutation Database (HGMD)
STAC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAC2 Gene

Disorders for STAC2 Gene

Relevant External Links for STAC2

Genetic Association Database (GAD)
STAC2
Human Genome Epidemiology (HuGE) Navigator
STAC2
genes like me logo Genes that share disorders with STAC2: view

No data available for UniProtKB/Swiss-Prot for STAC2 Gene

Publications for STAC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3
  5. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass A.L. … Elledge S.J. (Science 2008) 3

Products for STAC2 Gene

Sources for STAC2 Gene

Back to Top

Content