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Aliases for STAC2 Gene

Aliases for STAC2 Gene

  • SH3 And Cysteine Rich Domain 2 2 3 5
  • 24b2/STAC2 3 4
  • SRC Homology 3 And Cysteine-Rich Domain-Containing Protein 2 3
  • Src Homology 3 And Cysteine-Rich Domain-Containing Protein 2 4
  • SH3 And Cysteine-Rich Domain-Containing Protein 2 3
  • 24b2 3

External Ids for STAC2 Gene

Previous GeneCards Identifiers for STAC2 Gene

  • GC17M037741
  • GC17M034620
  • GC17M037368
  • GC17M033161

Summaries for STAC2 Gene

Entrez Gene Summary for STAC2 Gene

  • This gene encodes a protein containing an SH3 domain and a zinc finger domain. The encoded protein has been shown to regulate calcium channel inactivation in a human cell line. Reduced expression of this gene has been observed in human heart failure. [provided by RefSeq, May 2017]

GeneCards Summary for STAC2 Gene

STAC2 (SH3 And Cysteine Rich Domain 2) is a Protein Coding gene. An important paralog of this gene is STAC.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAC2 Gene

Genomics for STAC2 Gene

Regulatory Elements for STAC2 Gene

Enhancers for STAC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G039208 1.8 FANTOM5 Ensembl ENCODE dbSUPER 21.2 +16.2 16242 2.5 HDGF ZNF493 ZNF133 SIN3A FEZF1 GLIS2 FOS SMARCB1 MAFF SMARCA4 STAC2 THRA CACNB1 GC17P039212 RPL19
GH17G039658 2.2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 10.2 -437.8 -437819 10.4 MLX CREB3L1 AGO1 ZFP64 DMAP1 SLC30A9 ZNF143 ZNF263 SP3 NFYC PGAP3 MED1 ENSG00000266469 LOC100287808 STAC2 CDK12 MSL1 FBXL20 TCAP STARD3
GH17G039191 1.4 ENCODE dbSUPER 9.7 +28.9 28875 11.7 CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 ZNF610 GLIS1 ENSG00000266469 CDK12 SNORA21 MSL1 MED1 SNORD124 PGAP3 ENSG00000275665 RPL19 STAC2
GH17G038724 1.4 ENCODE dbSUPER 5.4 +496.4 496410 10.8 HDGF CREB3L1 ARNT AGO1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 PCGF2 MLLT6 PGAP3 PSMB3 CWC25 CISD3 STAC2 ENSG00000279119
GH17G039263 0.2 ENCODE 11.9 -38.3 -38302 0.6 STAC2 RPL19 CACNB1 PIR53968 GC17P039362
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STAC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for STAC2 Gene

Chromosome:
17
Start:
39,210,536 bp from pter
End:
39,225,872 bp from pter
Size:
15,337 bases
Orientation:
Minus strand

Genomic View for STAC2 Gene

Genes around STAC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAC2 Gene

Proteins for STAC2 Gene

  • Protein details for STAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMT1-STAC2_HUMAN
    Recommended name:
    SH3 and cysteine-rich domain-containing protein 2
    Protein Accession:
    Q6ZMT1
    Secondary Accessions:
    • Q32MA3

    Protein attributes for STAC2 Gene

    Size:
    411 amino acids
    Molecular mass:
    45009 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STAC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAC2 Gene

Post-translational modifications for STAC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STAC2 Gene

No data available for DME Specific Peptides for STAC2 Gene

Domains & Families for STAC2 Gene

Protein Domains for STAC2 Gene

Suggested Antigen Peptide Sequences for STAC2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with STAC2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for STAC2 Gene

Function for STAC2 Gene

Gene Ontology (GO) - Molecular Function for STAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with STAC2: view
genes like me logo Genes that share phenotypes with STAC2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STAC2 Gene

Localization for STAC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STAC2 gene
Compartment Confidence
nucleus 3
cytosol 3

Gene Ontology (GO) - Cellular Components for STAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with STAC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for STAC2 Gene

Pathways & Interactions for STAC2 Gene

SuperPathways for STAC2 Gene

No Data Available

Interacting Proteins for STAC2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000327509%0d%0a9606.ENSP00000283921%0d%0a
Selected Interacting proteins: Q6ZMT1-STAC2_HUMAN ENSP00000327509 for STAC2 Gene via IID UniProtKB STRING

Gene Ontology (GO) - Biological Process for STAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with STAC2: view

No data available for Pathways by source and SIGNOR curated interactions for STAC2 Gene

Drugs & Compounds for STAC2 Gene

(3) Additional Compounds for STAC2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with STAC2: view

Transcripts for STAC2 Gene

Unigene Clusters for STAC2 Gene

SH3 and cysteine rich domain 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STAC2 Gene

No ASD Table

Relevant External Links for STAC2 Gene

GeneLoc Exon Structure for
STAC2
ECgene alternative splicing isoforms for
STAC2

Expression for STAC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STAC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STAC2 Gene

This gene is overexpressed in Artery - Tibial (x7.9), Breast - Mammary Tissue (x5.8), Skin - Sun Exposed (Lower leg) (x4.6), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for STAC2 Gene

This gene is overexpressed in Retina (54.0) and Frontal cortex (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STAC2 Gene



Protein tissue co-expression partners for STAC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of STAC2 Gene:

STAC2

SOURCE GeneReport for Unigene cluster for STAC2 Gene:

Hs.145068

Evidence on tissue expression from TISSUES for STAC2 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with STAC2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STAC2 Gene

Orthologs for STAC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for STAC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STAC2 34 35
  • 93.15 (n)
cow
(Bos Taurus)
Mammalia STAC2 34 35
  • 90.93 (n)
dog
(Canis familiaris)
Mammalia STAC2 34 35
  • 90.93 (n)
mouse
(Mus musculus)
Mammalia Stac2 34 16 35
  • 89.46 (n)
rat
(Rattus norvegicus)
Mammalia Stac2 34
  • 88.89 (n)
oppossum
(Monodelphis domestica)
Mammalia STAC2 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STAC2 35
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STAC2 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stac2 34
  • 63.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG43729 35
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 19 (a)
OneToMany
Species where no ortholog for STAC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for STAC2 Gene

ENSEMBL:
Gene Tree for STAC2 (if available)
TreeFam:
Gene Tree for STAC2 (if available)

Paralogs for STAC2 Gene

Paralogs for STAC2 Gene

(6) SIMAP similar genes for STAC2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with STAC2: view

Variants for STAC2 Gene

Sequence variations from dbSNP and Humsavar for STAC2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs863223351 Likely pathogenic 39,218,007(-) GGACA(A/G)GGGCC reference, missense
rs1000270844 -- 39,224,313(+) CAAAA(-/T)ACCGG intron-variant
rs1000354566 -- 39,220,667(+) CGGGG(G/T)TTCAC intron-variant
rs1000393827 -- 39,210,117(+) CGGAT(G/T)GGTAC downstream-variant-500B
rs1000580349 -- 39,224,104(+) CCCTA(C/T)GGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STAC2 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv833441 CNV loss 17160897

Variation tolerance for STAC2 Gene

Residual Variation Intolerance Score: 24.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STAC2 Gene

Human Gene Mutation Database (HGMD)
STAC2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STAC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAC2 Gene

Disorders for STAC2 Gene

Relevant External Links for STAC2

Genetic Association Database (GAD)
STAC2
Human Genome Epidemiology (HuGE) Navigator
STAC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STAC2

No disorders were found for STAC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STAC2 Gene

Publications for STAC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Stac adaptor proteins regulate trafficking and function of muscle and neuronal L-type Ca2+ channels. (PMID: 25548159) Polster A. … Beam K.G. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3 64
  4. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. (PMID: 25184681) Hill S.J. … Livingston D.M. (Genes Dev. 2014) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for STAC2 Gene

Sources for STAC2 Gene

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