STAC Gene
protein-coding GIFtS: 48
GCID: GC03P036397
|
|
SH3 and cysteine rich domain(Previous name: src homology three (SH3) and cysteine rich domain )
| |
Aliases
for STAC gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| SH3 And Cysteine Rich Domain1 2 | | STAC11 2 | | Src Homology Three (SH3) And Cysteine Rich Domain1 2 | | Src Homology 3 And Cysteine-Rich Domain-Containing Protein2 3 | | SH3 And Cysteine-Rich Domain-Containing Protein2 |
| External Ids: | HGNC: 113531 | Entrez Gene: 67692 | Ensembl: ENSG000001446817 | OMIM: 6023175 | UniProtKB: Q994693 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n339291 | |
Export aliases for STAC gene to outside databasesPrevious GC identifers: GC03P035724 GC03P036235 GC03P036382
Summaries
for STAC gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: STAC_HUMAN, Q99469Function: Probably involved in a neuron-specific signal transduction
|
Genomic Views
for STAC gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STAC gene promoter:
AhR Max1 USF1 Spz1 Tal-1 CUTL1 Cdc5 E47 PPAR-alpha USF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for STAC
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAC |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p22.3 Ensembl cytogenetic band: 3p22.3 HGNC cytogenetic band: 3p22.3STAC Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P036397: view genomic region
(about GC identifiers)
Start:
|
36,421,836 bp from pter |
End:
|
36,589,499 bp from pter |
Size:
|
167,664 bases |
Orientation:
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plus strand |
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Proteins
for STAC gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STAC_HUMAN, Q99469 (See
protein sequence)Recommended Name: SH3 and cysteine-rich domain-containing protein Size: 402 amino acids; 44554 Da
Subcellular location: Cytoplasm
1 PDB 3D structure from  and Proteopedia  for STAC:2DL4 (3D)
Secondary accessions: B2R8S8Explore the universe of human proteins at neXtProt for STAC: NX_Q99469
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q99469
STAC Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003140.1
ENSEMBL proteins: ENSP00000273183 ENSP00000393713 ENSP00000397521 ENSP00000398403
Human Recombinant Protein Products for STAC:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
STAC for ontologies About GeneDecksing
STAC Antibody Products:
Assay Products for STAC: |
Protein
Domains /
Families
for STAC gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STAC for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q99469ProtoNet protein and cluster: Q99469 2 Blocks protein families: IPB001452 SH3 domain signature IPB011511 Variant SH3
UniProtKB/Swiss-Prot: STAC_HUMAN, Q99469Similarity: Contains 1 phorbol-ester/DAG-type zinc fingerSimilarity: Contains 1 SH3 domain |
Function
for STAC gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: STAC_HUMAN, Q99469Function: Probably involved in a neuron-specific signal transduction Genatlas biochemistry entry for STAC:neuron-specific protein,expressed predominantly in hippocampus,cerebellum and inferior olive
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0046872 | metal ion binding |
IEA | -- |
STAC for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAC (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAC
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: STAC (NM_003149) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STAC | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAC |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAC |
|
Pathways & Interactions
for STAC gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STAC
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/8 Interacting proteins for STAC (Q994692, 3 ENSP000002731834) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
STAC for ontologies About GeneDecksing
|
Drugs & Compounds
for STAC gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for STAC
10/843 HMDB Compounds for STAC (see all 843) About this table
Search CenterWatch for drugs/clinical trials and news about STAC
|
Transcripts
for STAC gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STAC gene: NM_003149.1 Unigene Cluster for STAC: SH3 and cysteine rich domain Hs.56045 [show with all ESTs]Unigene Representative Sequence: BX5379268 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000273183(uc003cgh.1 uc011aya.1) ENST00000457375 ENST00000427486
ENST00000434649 ENST00000476388(uc010hgd.1) ENST00000486143 ENST00000473452
ENST00000465064
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAC (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAC
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: STAC (NM_003149) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STAC | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAC |
Additional cDNA sequence: AK056893.1 AK299160.1 AK302697.1 AK310425.1 AK313493.1 BC020221.1 BX537926.1 D86640.1 5 DOTS entries: DT.410822 DT.95149525 DT.100776823 DT.100020473 DT.40123440 24/62 AceView cDNA sequences (see all 62): AI370524 BI819507 BM718498 BM663504 AW137199 BM683543 D86640 AI471117 AK056893 BQ222052 BX537926 BC020221 CR594767 BX117845 AA450217 BX104544 BE262331 NM_003149 BE671984 CA309814 BF311339 AU130664 BI917413 CD370246
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for STAC (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for STAC
|
Expression
for STAC gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STAC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See STAC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STAC
SOURCE GeneReport for Unigene cluster: Hs.56045
SABiosciences Custom PCR Arrays for STAC
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STAC
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STAC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAC | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAC |
Orthologs
for STAC gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for STAC gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for STAC (if available)
TreeFam Gene Tree for STAC (if available) |
Paralogs
for STAC gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STAC gene
- STAC32 STAC22
6 SIMAP similar genes for STAC using alignment to 5 protein entries: STAC_HUMAN (see all proteins):SH3GL2 ITSN1 SH3GL1 STAC2 STAC3 ARHGEF7
STAC for paralogs About GeneDecksing
|
Genomic Variants
for STAC gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STAC (36421836 - 36589499 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for STAC: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STAC |
|
Disorders
/ Diseases
for STAC gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STAC for disorders About GeneDecksing
OMIM gene information: 602317
OMIM disorders: --
3  diseases for STAC: About MalaCardsneuronitis pancreatic cancer pancreatitis
Export disorders for STAC gene to outside databases
|
Publications
for STAC gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STAC gene integrated from 9 sources:
(articles sorted by number of sources associating them with STAC) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Stac, a novel neuron-specific protein with cysteine-rich and SH3 domains. (PubMed id 8954993)1, 2, 3 Suzuki H.... Watanabe S. (1996)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Assignment of STAC to human chromosome band 3p22.3 be tween D3S3718 and D3S1611. (PubMed id 10393425)1, 3 Petek E....Wagner K. (1999)
- Pilot genome-wide association search identifies potent ial loci for risk of erectile dysfunction in type 1 diabetes using the DCCT/EDIC study cohort. (PubMed id 22704111)1 Hotaling J.M....Wessells H. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
- Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PubMed id 18654987)1 Thalappilly S....Dusetti N.J. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for STAC gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing STAC gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STAC gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STAC gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for STAC | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for STAC gene:
Search GeneIP for patents involving STAC
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for STAC gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for STAC | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STAC | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STAC | | | OriGene Protein Over-expression Lysate for STAC | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for STAC | | OriGene 3'-UTR Clone for STAC | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAC | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAC | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for STAC | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for STAC | | OriGene Custom Protein Services for STAC | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STAC | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STAC | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAC | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAC |
| |
 |  |  |  | |
| | | | Search Tocris compounds for STAC |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | STAC Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAC |
|  |  |  |  | | | | Search ThermoFisher Antibodies for STAC |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAC |
| |  | |
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