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Aliases for STAC Gene

Aliases for STAC Gene

  • SH3 And Cysteine Rich Domain 2 3
  • SRC Homology 3 And Cysteine-Rich Domain-Containing Protein 3
  • Src Homology 3 And Cysteine-Rich Domain-Containing Protein 4
  • Src Homology Three (SH3) And Cysteine Rich Domain 2
  • SH3 And Cysteine-Rich Domain-Containing Protein 3
  • STAC1 3

External Ids for STAC Gene

Previous GeneCards Identifiers for STAC Gene

  • GC03P035724
  • GC03P036235
  • GC03P036382
  • GC03P036397

Summaries for STAC Gene

GeneCards Summary for STAC Gene

STAC (SH3 And Cysteine Rich Domain) is a Protein Coding gene. An important paralog of this gene is STAC3.

UniProtKB/Swiss-Prot for STAC Gene

  • Probably involved in a neuron-specific signal transduction

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAC Gene

Genomics for STAC Gene

Regulatory Elements for STAC Gene

Genomic Location for STAC Gene

Start:
36,380,344 bp from pter
End:
36,548,007 bp from pter
Size:
167,664 bases
Orientation:
Plus strand

Genomic View for STAC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STAC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAC Gene

Proteins for STAC Gene

  • Protein details for STAC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99469-STAC_HUMAN
    Recommended name:
    SH3 and cysteine-rich domain-containing protein
    Protein Accession:
    Q99469
    Secondary Accessions:
    • B2R8S8

    Protein attributes for STAC Gene

    Size:
    402 amino acids
    Molecular mass:
    44554 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for STAC Gene

neXtProt entry for STAC Gene

Proteomics data for STAC Gene at MOPED

Post-translational modifications for STAC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STAC Gene

No data available for DME Specific Peptides for STAC Gene

Domains for STAC Gene

Protein Domains for STAC Gene

Graphical View of Domain Structure for InterPro Entry

Q99469

UniProtKB/Swiss-Prot:

STAC_HUMAN :
  • Q99469
Domain:
  • Contains 1 SH3 domain.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with STAC: view

No data available for Gene Families for STAC Gene

Function for STAC Gene

Molecular function for STAC Gene

GENATLAS Biochemistry: neuron-specific protein,expressed predominantly in hippocampus,cerebellum and inferior olive
UniProtKB/Swiss-Prot Function: Probably involved in a neuron-specific signal transduction

Gene Ontology (GO) - Molecular Function for STAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16260042
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with STAC: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STAC

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for STAC Gene

Localization for STAC Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAC Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAC Gene COMPARTMENTS Subcellular localization image for STAC gene
Compartment Confidence
cytosol 5
nucleus 2
endosome 1

Gene Ontology (GO) - Cellular Components for STAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol NAS 8954993
genes like me logo Genes that share ontologies with STAC: view

Pathways for STAC Gene

SuperPathways for STAC Gene

No Data Available

Gene Ontology (GO) - Biological Process for STAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 8954993
GO:0034605 cellular response to heat IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with STAC: view

No data available for Pathways by source for STAC Gene

Compounds for STAC Gene

(843) HMDB Compounds for STAC Gene

Compound Synonyms Cas Number PubMed IDs
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
DG(14:0/16:0/0:0)
  • DAG(30:0)
Not Available
DG(14:0/16:1(9Z)/0:0)
  • DG(30:1)
Not Available
genes like me logo Genes that share compounds with STAC: view

Transcripts for STAC Gene

Unigene Clusters for STAC Gene

SH3 and cysteine rich domain:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STAC

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STAC Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - - - - -
SP3:
SP4: - - - -
SP5: -
SP6:

Relevant External Links for STAC Gene

GeneLoc Exon Structure for
STAC
ECgene alternative splicing isoforms for
STAC

Expression for STAC Gene

mRNA expression in normal human tissues for STAC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STAC Gene

This gene is overexpressed in Artery - Aorta (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for STAC Gene

SOURCE GeneReport for Unigene cluster for STAC Gene Hs.56045

genes like me logo Genes that share expressions with STAC: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for STAC Gene

Orthologs for STAC Gene

This gene was present in the common ancestor of animals.

Orthologs for STAC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STAC 35
  • 99.75 (n)
  • 99.75 (a)
STAC 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STAC 35
  • 91.69 (n)
  • 92.52 (a)
STAC 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STAC 35
  • 92.1 (n)
  • 91.02 (a)
STAC 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stac 35
  • 85.7 (n)
  • 83.54 (a)
Stac 16
Stac 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STAC 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STAC 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stac 35
  • 84.7 (n)
  • 84.04 (a)
chicken
(Gallus gallus)
Aves STAC 35
  • 77.89 (n)
  • 78.64 (a)
STAC 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STAC 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stac 35
  • 69.42 (n)
  • 71 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100005402 35
  • 64.74 (n)
  • 63.22 (a)
STAC 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG43729 36
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToMany
Species with no ortholog for STAC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STAC Gene

ENSEMBL:
Gene Tree for STAC (if available)
TreeFam:
Gene Tree for STAC (if available)

Paralogs for STAC Gene

Paralogs for STAC Gene

Selected SIMAP similar genes for STAC Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with STAC: view

Variants for STAC Gene

Sequence variations from dbSNP and Humsavar for STAC Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs715660 -- 36,461,575(+) AAATG(A/C)TATGG intron-variant
rs721110 -- 36,523,804(+) GGCAC(A/G)GCTCT intron-variant
rs721111 -- 36,523,863(+) ACATC(A/G)CACAA intron-variant
rs728082 -- 36,408,887(+) CTCCA(A/G)TTGTA intron-variant
rs870445 -- 36,447,003(-) CTTTC(A/G)TAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STAC Gene

Variant ID Type Subtype PubMed ID
nsv876700 CNV Loss 21882294
dgv281n21 CNV Loss 19592680
esv2725154 CNV Deletion 23290073
esv2659382 CNV Deletion 23128226
nsv3761 CNV Insertion 18451855
nsv876701 CNV Loss 21882294
esv2668360 CNV Deletion 23128226
esv2678470 CNV Deletion 23128226
esv2658392 CNV Deletion 23128226

Relevant External Links for STAC Gene

HapMap Linkage Disequilibrium report
STAC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAC Gene

Disorders for STAC Gene

Relevant External Links for STAC

Genetic Association Database (GAD)
STAC
genes like me logo Genes that share disorders with STAC: view

No data available for UniProtKB/Swiss-Prot for STAC Gene

Publications for STAC Gene

  1. Stac, a novel neuron-specific protein with cysteine-rich and SH3 domains. (PMID: 8954993) Suzuki H. … Watanabe S. (Biochem. Biophys. Res. Commun. 1996) 2 3 4
  2. Assignment of STAC to human chromosome band 3p22.3 between D3S3718 and D3S1611. (PMID: 10393425) Petek E. … Wagner K. (Cytogenet. Cell Genet. 1999) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Rapid identification of 14-3-3-binding proteins by protein microarray analysis. (PMID: 16260042) Satoh J. … Yamamura T. (J. Neurosci. Methods 2006) 3
  5. Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PMID: 18654987) Thalappilly S. … Dusetti N.J. (Proteomics 2008) 3

Products for STAC Gene

Sources for STAC Gene

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