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STAC Gene

protein-coding   GIFtS: 50
GCID: GC03P036421

SH3 And Cysteine Rich Domain

(Previous name: src homology three (SH3) and cysteine rich domain)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SH3 And Cysteine Rich Domain1 2
Src Homology Three (SH3) And Cysteine Rich Domain1 2
Src Homology 3 And Cysteine-Rich Domain-Containing Protein2 3
STAC12
SH3 And Cysteine-Rich Domain-Containing Protein2

External Ids:    HGNC: 113531   Entrez Gene: 67692   Ensembl: ENSG000001446817   OMIM: 6023175   UniProtKB: Q994693   

Export aliases for STAC gene to outside databases

Previous GC identifers: GC03P035724 GC03P036235 GC03P036382 GC03P036397


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for STAC Gene:
STAC (SH3 and cysteine rich domain) is a protein-coding gene. Diseases associated with STAC include type 1 diabetes, and pancreatic cancer. An important paralog of this gene is STAC3.

UniProtKB/Swiss-Prot: STAC_HUMAN, Q99469
Function: Probably involved in a neuron-specific signal transduction




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STAC gene promoter:
         AhR   Max1   USF1   Spz1   Tal-1   CUTL1   Cdc5   E47   PPAR-alpha   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTAC promoter sequence
   Search Chromatin IP Primers for STAC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STAC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.3   Ensembl cytogenetic band:  3p22.3   HGNC cytogenetic band: 3p22.3

STAC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAC gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P036421:  view genomic region     (about GC identifiers)

Start:
36,421,836 bp from pter      End:
36,589,499 bp from pter
Size:
167,664 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STAC_HUMAN, Q99469 (See protein sequence)
Recommended Name: SH3 and cysteine-rich domain-containing protein  
Size: 402 amino acids; 44554 Da
1 PDB 3D structure from and Proteopedia for STAC:
2DL4 (3D)    
Secondary accessions: B2R8S8

Explore the universe of human proteins at neXtProt for STAC: NX_Q99469

Explore proteomics data for STAC at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See STAC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003140.1  
    ENSEMBL proteins: 
     ENSP00000273183   ENSP00000393713   ENSP00000397521   ENSP00000398403  

    STAC Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for STAC
    OriGene Protein Over-expression Lysate for STAC
    OriGene MassSpec for STAC
    OriGene Custom Protein Services for STAC
    GenScript Custom Purified and Recombinant Proteins Services for STAC
    Novus Biologicals STAC Proteins
    Novus Biologicals STAC Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STAC

    STAC Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
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    Novus Biologicals STAC Antibodies
    Abcam antibodies for STAC
    Cloud-Clone Corp. Antibodies for STAC
    ThermoFisher Antibody for STAC
    LSBio Antibodies in human, mouse, rat for STAC

    STAC Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STAC
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for STAC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STAC
    Cloud-Clone Corp. CLIAs for STAC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR013315 Spectrin_alpha_SH3
     IPR011511 SH3_2
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q99469

    ProtoNet protein and cluster: Q99469

    2 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: STAC_HUMAN, Q99469
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 SH3 domain


    STAC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STAC_HUMAN, Q99469
    Function: Probably involved in a neuron-specific signal transduction

         Genatlas biochemistry entry for STAC:
    neuron-specific protein,expressed predominantly in hippocampus,cerebellum and inferior olive

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16260042
    GO:0046872metal ion binding IEA--
         
    STAC for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STAC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STAC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STAC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STAC

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat STAC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STAC (see all 37):
    hsa-miR-128 hsa-miR-578 hsa-miR-30d hsa-miR-124 hsa-miR-9 hsa-miR-30a hsa-miR-4330 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidSTAC 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STAC
    Predesigned siRNA for gene silencing in human, mouse, rat STAC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STAC

    Clone
    Products:
         
    OriGene clones in human, mouse for STAC (see all 7)
    OriGene ORF clones in mouse, rat for STAC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STAC (NM_003149)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAC

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STAC
    Browse ESI BIO Cell Lines and PureStem Progenitors for STAC 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STAC_HUMAN, Q99469: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus2
    endosome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol NAS8954993

    STAC for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STAC
    Interactions:

        Search GeneGlobe Interaction Network for STAC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for STAC (Q994691, 2, 3 ENSP000002731834) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARP2Q9UGN51, 2, 3, ENSP000002504164EBI-2652799,EBI-2795348 MINT-8201802 MINT-8202297 I2D: score=1 STRING: ENSP00000250416
    YWHAEP622581, 2, 3, ENSP000002643354EBI-2652799,EBI-356498 MINT-7188321 MINT-7188418 I2D: score=1 STRING: ENSP00000264335
    LIMD1Q9UGP43, ENSP000002733174I2D: score=1 STRING: ENSP00000273317
    LMNAP025453, ENSP000003572834I2D: score=1 STRING: ENSP00000357283
    TRIP6Q156543, ENSP000002004574I2D: score=1 STRING: ENSP00000200457
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction NAS8954993
    GO:0034605cellular response to heat IEA--
    GO:0035556intracellular signal transduction IEA--

    STAC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STAC

    Selected HMDB Compounds for STAC (see all 843)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for STAC gene: 
    NM_003149.1  

    Unigene Cluster for STAC:

    SH3 and cysteine rich domain
    Hs.56045  [show with all ESTs]
    Unigene Representative Sequence: BX537926
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273183(uc003cgh.1 uc011aya.1) ENST00000457375 ENST00000427486
    ENST00000434649 ENST00000476388(uc010hgd.1) ENST00000486143 ENST00000473452
    ENST00000465064
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STAC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STAC (see all 37):
    hsa-miR-128 hsa-miR-578 hsa-miR-30d hsa-miR-124 hsa-miR-9 hsa-miR-30a hsa-miR-4330 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidSTAC 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STAC
    Predesigned siRNA for gene silencing in human, mouse, rat STAC
    Clone
    Products:
         
    OriGene clones in human, mouse for STAC (see all 7)
    OriGene ORF clones in mouse, rat for STAC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STAC (NM_003149)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAC
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for STAC
    OriGene qSTAR qPCR primer pairs in human, mouse for STAC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STAC
      QuantiTect SYBR Green Assays in human, mouse, rat STAC
      QuantiFast Probe-based Assays in human, mouse, rat STAC

    Additional mRNA sequence: 

    AK056893.1 AK299160.1 AK302697.1 AK310425.1 AK313493.1 BC020221.1 BX537926.1 D86640.1 

    5 DOTS entries:

    DT.410822  DT.95149525  DT.100776823  DT.100020473  DT.40123440 

    Selected AceView cDNA sequences (see all 62):

    BM663504 BE671984 D86640 AI370524 BI819507 BM683543 AW137199 BM718498 
    AK056893 AI471117 BX104544 BX117845 AA450217 NM_003149 BE262331 BQ222052 
    BC020221 CR594767 BX537926 BE220310 AA131521 BF313367 BF311339 AU130664 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STAC (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
    SP1:                                -     -                                               -                     
    SP2:                    -           -     -     -     -                                                         
    SP3:                                                                                                            
    SP4:                                -     -     -     -                                                         
    SP5:                                -                                                                           


    ECgene alternative splicing isoforms for STAC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STAC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    STAC Expression
    About this image


    STAC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H9 (Naive)
    STAC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STAC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.56045
        Custom PCR Arrays for STAC
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for STAC
    OriGene qSTAR qPCR primer pairs in human, mouse for STAC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STAC
    QuantiTect SYBR Green Assays in human, mouse, rat STAC
    QuantiFast Probe-based Assays in human, mouse, rat STAC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for STAC gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stac1 , 5 src homology three (SH3) and cysteine rich domain1, 5 85.7(n)1
    83.54(a)1
      9 (61.81 cM)5
    208401  NM_016853.21  NP_058549.11 
     1115614375 
    chicken
    (Gallus gallus)
    Aves STAC1 SH3 and cysteine rich domain 77.89(n)
    78.64(a)
      428460  XM_426020.4  XP_426020.3 
    lizard
    (Anolis carolinensis)
    Reptilia STAC6
    SH3 and cysteine rich domain
    81(a)
    1 ↔ 1
    6(43209135-43245700)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia stac1 SH3 and cysteine rich domain 69.42(n)
    71(a)
      101731598  XM_004915346.1  XP_004915403.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000054021 SH3 and cysteine-rich domain-containing protein-like 64.74(n)
    63.22(a)
      100005402  XM_001344434.4  XP_001344470.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG437296
    --
    7(a)
    1 → many
    2R(11288601-11358596)


    ENSEMBL Gene Tree for STAC (if available)
    TreeFam Gene Tree for STAC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STAC gene
    STAC32  STAC22  
    6 SIMAP similar genes for STAC using alignment to 5 protein entries:     STAC_HUMAN (see all proteins):
    SH3GL2    ITSN1    SH3GL1    STAC2    STAC3    ARHGEF7

    STAC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STAC (see all 3223)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs770024621,2
    C,F--36360976(+) CAAAAG/AAAAAA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs2020467591,2
    --36360976(+) CAAAA-/GAAAAA 1 -- us2k10--------
    rs1447332461,2
    --36360983(+) AAAAAA/GGGATG 1 -- us2k10--------
    rs1398413221,2
    --36361032(+) CAAGAA/CTGGAA 1 -- us2k10--------
    rs738288451,2
    C,F--36361407(+) TGAAGC/ACATTT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1474267341,2
    --36361436(+) CCGTAC/TTGAGG 1 -- us2k10--------
    rs65504221,2
    C,F,A,H--36361476(+) GCTAAA/GTGCTG 1 -- us2k126Minor allele frequency- G:0.29NS EA NA WA CSA 2949
    rs1148360941,2
    F--36361536(+) GGAAAG/AAGTAA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs757539321,2
    C,F--36361643(+) GTTAAA/GTATTT 1 -- us2k11Minor allele frequency- G:0.17WA 118
    rs784799041,2
    C,F--36361657(+) CCGAAT/CTTCAA 1 -- us2k11Minor allele frequency- C:0.08NA 120

    HapMap Linkage Disequilibrium report for STAC (36421836 - 36589499 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for STAC:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678470CNV Deletion23128226
    esv2668360CNV Deletion23128226
    esv2659382CNV Deletion23128226
    esv2725154CNV Deletion23290073
    esv2658392CNV Deletion23128226
    nsv3761CNV Insertion18451855
    dgv281n21CNV Loss19592680
    nsv876701CNV Loss21882294
    nsv876700CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STAC
    DNA2.0 Custom Variant and Variant Library Synthesis for STAC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602317    OMIM disorders: --

    4 diseases for STAC:    
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    type 1 diabetes    pancreatic cancer    pancreatitis    neuronitis


    STAC for disorders           About GeneDecksing

    Genetic Association Database (GAD): STAC

    Export disorders for STAC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STAC gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with STAC)
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    1. Stac, a novel neuron-specific protein with cysteine-rich and SH3 domains. (PubMed id 8954993)1, 2, 3 Suzuki H.... Watanabe S. (Biochem. Biophys. Res. Commun. 1996)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Assignment of STAC to human chromosome band 3p22.3 between D3S3718 and D3S1611. (PubMed id 10393425)1, 3 Petek E....Wagner K. (Cytogenet. Cell Genet. 1999)
    4. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PubMed id 23940030)1 Teixeira F.R....Gomes M.D. (J. Biol. Chem. 2013)
    5. A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. (PubMed id 23936387)1 A9stensson M....Torinsson-Naluai A.8. (PLoS ONE 2013)
    6. Pilot genome-wide association search identifies potential loci for risk of erectile dysfunction in type 1 diabetes using the DCCT/EDIC study cohort. (PubMed id 22704111)1 Hotaling J.M....Wessells H. (J. Urol. 2012)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (Mol. Syst. Biol. 2009)
    9. Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PubMed id 18654987)1 Thalappilly S....Dusetti N.J. (Proteomics 2008)
    10. Rapid identification of 14-3-3-binding proteins by protein microarray analysis. (PubMed id 16260042)1 Satoh J.... Yamamura T. (J. Neurosci. Methods 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6769 HGNC: 11353 AceView: STAC Ensembl:ENSG00000144681 euGenes: HUgn6769
    ECgene: STAC H-InvDB: STAC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STAC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STAC gene:
    Search GeneIP for patents involving STAC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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