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Aliases for STAC Gene

Aliases for STAC Gene

  • SH3 And Cysteine Rich Domain 2 3 5
  • SRC Homology 3 And Cysteine-Rich Domain-Containing Protein 3
  • Src Homology 3 And Cysteine-Rich Domain-Containing Protein 4
  • Src Homology Three (SH3) And Cysteine Rich Domain 2
  • STAC1 3

External Ids for STAC Gene

Previous GeneCards Identifiers for STAC Gene

  • GC03P035724
  • GC03P036235
  • GC03P036382
  • GC03P036397

Summaries for STAC Gene

GeneCards Summary for STAC Gene

STAC (SH3 And Cysteine Rich Domain) is a Protein Coding gene. An important paralog of this gene is STAC3.

UniProtKB/Swiss-Prot for STAC Gene

  • Probably involved in a neuron-specific signal transduction.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAC Gene

Genomics for STAC Gene

Regulatory Elements for STAC Gene

Promoters for STAC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STAC on UCSC Golden Path with GeneCards custom track

Genomic Location for STAC Gene

Chromosome:
3
Start:
36,380,344 bp from pter
End:
36,548,011 bp from pter
Size:
167,668 bases
Orientation:
Plus strand

Genomic View for STAC Gene

Genes around STAC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAC Gene

Proteins for STAC Gene

  • Protein details for STAC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99469-STAC_HUMAN
    Recommended name:
    SH3 and cysteine-rich domain-containing protein
    Protein Accession:
    Q99469
    Secondary Accessions:
    • B2R8S8

    Protein attributes for STAC Gene

    Size:
    402 amino acids
    Molecular mass:
    44554 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for STAC Gene

neXtProt entry for STAC Gene

Proteomics data for STAC Gene at MOPED

Post-translational modifications for STAC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STAC Gene

Antibody Products

No data available for DME Specific Peptides for STAC Gene

Domains & Families for STAC Gene

Protein Domains for STAC Gene

Graphical View of Domain Structure for InterPro Entry

Q99469

UniProtKB/Swiss-Prot:

STAC_HUMAN :
  • Contains 1 SH3 domain.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • Contains 1 SH3 domain.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with STAC: view

No data available for Gene Families for STAC Gene

Function for STAC Gene

Molecular function for STAC Gene

GENATLAS Biochemistry:
neuron-specific protein,expressed predominantly in hippocampus,cerebellum and inferior olive
UniProtKB/Swiss-Prot Function:
Probably involved in a neuron-specific signal transduction.

Phenotypes for STAC Gene

genes like me logo Genes that share phenotypes with STAC: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STAC Gene

Localization for STAC Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAC Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAC Gene COMPARTMENTS Subcellular localization image for STAC gene
Compartment Confidence
cytosol 5
nucleus 2
endosome 1

No data available for Gene Ontology (GO) - Cellular Components for STAC Gene

Pathways & Interactions for STAC Gene

SuperPathways for STAC Gene

No Data Available

Gene Ontology (GO) - Biological Process for STAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 8954993
genes like me logo Genes that share ontologies with STAC: view

No data available for Pathways by source and SIGNOR curated interactions for STAC Gene

Drugs & Compounds for STAC Gene

(3) Additional Compounds for STAC Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with STAC: view

Transcripts for STAC Gene

Unigene Clusters for STAC Gene

SH3 and cysteine rich domain:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STAC Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - - - - -
SP3:
SP4: - - - -
SP5: -
SP6:

Relevant External Links for STAC Gene

GeneLoc Exon Structure for
STAC
ECgene alternative splicing isoforms for
STAC

Expression for STAC Gene

mRNA expression in normal human tissues for STAC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STAC Gene

This gene is overexpressed in Artery - Aorta (x5.6).

Protein differential expression in normal tissues from HIPED for STAC Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STAC Gene



SOURCE GeneReport for Unigene cluster for STAC Gene Hs.56045

genes like me logo Genes that share expression patterns with STAC: view

Protein tissue co-expression partners for STAC Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for STAC Gene

Orthologs for STAC Gene

This gene was present in the common ancestor of animals.

Orthologs for STAC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STAC 35
  • 91.69 (n)
  • 92.52 (a)
STAC 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STAC 35
  • 92.1 (n)
  • 91.02 (a)
STAC 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stac 35
  • 85.7 (n)
  • 83.54 (a)
Stac 16
Stac 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STAC 35
  • 99.75 (n)
  • 99.75 (a)
STAC 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stac 35
  • 84.7 (n)
  • 84.04 (a)
oppossum
(Monodelphis domestica)
Mammalia STAC 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STAC 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves STAC 35
  • 77.89 (n)
  • 78.64 (a)
STAC 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STAC 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stac 35
  • 69.42 (n)
  • 71 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100005402 35
  • 64.74 (n)
  • 63.22 (a)
STAC 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG43729 36
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToMany
Species with no ortholog for STAC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STAC Gene

ENSEMBL:
Gene Tree for STAC (if available)
TreeFam:
Gene Tree for STAC (if available)

Paralogs for STAC Gene

Paralogs for STAC Gene

(6) SIMAP similar genes for STAC Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with STAC: view

Variants for STAC Gene

Sequence variations from dbSNP and Humsavar for STAC Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs7634545 - 36,504,411(+) AGAAA(A/G)TGGCA reference, missense
rs715660 -- 36,461,575(+) AAATG(A/C)TATGG intron-variant
rs721110 -- 36,523,804(+) GGCAC(A/G)GCTCT intron-variant
rs721111 -- 36,523,863(+) ACATC(A/G)CACAA intron-variant
rs728082 -- 36,408,887(+) CTCCA(A/G)TTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STAC Gene

Variant ID Type Subtype PubMed ID
nsv876700 CNV Loss 21882294
dgv281n21 CNV Loss 19592680
esv2725154 CNV Deletion 23290073
esv2659382 CNV Deletion 23128226
nsv3761 CNV Insertion 18451855
nsv876701 CNV Loss 21882294
esv2668360 CNV Deletion 23128226
esv2678470 CNV Deletion 23128226
esv2658392 CNV Deletion 23128226

Variation tolerance for STAC Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.50; 64.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STAC Gene

HapMap Linkage Disequilibrium report
STAC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAC Gene

Disorders for STAC Gene

Relevant External Links for STAC

Genetic Association Database (GAD)
STAC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STAC

No disorders were found for STAC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STAC Gene

Publications for STAC Gene

  1. Stac, a novel neuron-specific protein with cysteine-rich and SH3 domains. (PMID: 8954993) Suzuki H. … Watanabe S. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 67
  2. Assignment of STAC to human chromosome band 3p22.3 between D3S3718 and D3S1611. (PMID: 10393425) Petek E. … Wagner K. (Cytogenet. Cell Genet. 1999) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. (PMID: 23936387) A9stensson M. … Torinsson-Naluai A.8. (PLoS ONE 2013) 3

Products for STAC Gene

Sources for STAC Gene

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