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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STAB2 Gene

protein-coding   GIFtS: 56
GCID: GC12P103981

stabilin 2

 Explore 23 diseases affiliated with
STAB2 via our new
 Human Malady Compendium 
Biological research products
for STAB2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Stabilin 21 2     FELL22
HARE1 2 3     CD44-Like Precursor FELL2
FEEL-21 3     FAS1 EGF-Like And X-Link Domain Containing Adhesion Molecule-22
FELL1 3     Fasciclin Egf-Like, Laminin-Type Egf-Like, And Link Domain-Containing Scavenger
Receptor-22
Hyaluronan Receptor For Endocytosis2 3     Hepatic Hyaluronan Clearance Receptor2
FEEL22 3     Hyaluronic Acid Receptor For Endocytosis2
FEX22 3     Stabilin-21
DKFZP434E03211     FAS1 EGF-Like And X-Link Domain-Containing Adhesion Molecule 23
STAB-21     Fasciclin, EGF-Like, Laminin-Type EGF-Like And Link Domain-Containing Scavenger
Receptor 23
FELE-22     

External Ids:    HGNC: 186291   Entrez Gene: 555762   Ensembl: ENSG000001360117   OMIM: 6085615   UniProtKB: Q8WWQ83   

Export aliases for STAB2 gene to outside databases

Previous GC identifers: GC12P103079 GC12M9E0035 GC12P103914 GC12P102483 GC12P101040


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STAB2:
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell
adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2
laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily
expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and
endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced
glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle
between the plasma membrane and lysosomes. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: STAB2_HUMAN, Q8WWQ8
Function: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds
to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger
receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated
low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to
maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of
bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment
in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense
against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for
heparin internalisation as well as HA and CS

Gene Wiki entry for STAB2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STAB2 gene promoter:
         c-Fos   AP-1   ATF-2   Meis-1b   YY1   c-Jun   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTAB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for STAB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.3   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q23.3

STAB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAB2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P103981:  view genomic region     (about GC identifiers)

Start:
103,981,051 bp from pter      End:
104,160,505 bp from pter
Size:
179,455 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: STAB2_HUMAN, Q8WWQ8 (See protein sequence)
Recommended Name: Stabilin-2 precursor  
Size: 2551 amino acids; 276988 Da
Subunit: Interacts with GULP1 and heparin. Also interacts with alpha-M/beta-2 integrin (ITGAM and ITGB2) and thymosin
beta 4 (TMSB4X and/or TMSB4Y)
Subcellular location: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Only a small amount appears
to be present at the cell surface
Sequence caution: Sequence=AAF82398.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAD18723.1; Type=Frameshift; Positions=240, 253, 588, 1586;
Secondary accessions: Q6ZMK2 Q7Z5N9 Q86UR4 Q8IUG9 Q8TES1 Q9H7H7 Q9NRY3

Explore the universe of human proteins at neXtProt for STAB2: NX_Q8WWQ8

Post-translational modifications:

  • Glycosylated1
  • Proteolytically processed to yield a 190 kDa protein1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WWQ8

  • STAB2 Protein expression data from MOPED and PaxDb:    About this image 
    STAB2 Protein Expression
    REFSEQ proteins: NP_060034.9  
    ENSEMBL proteins: 
     ENSP00000373539   ENSP00000449282   ENSP00000446629  
    Reactome Protein details: Q8WWQ8
    Human Recombinant Protein Products for STAB2: 
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    R&D Systems Recombinant & Natural Proteins for STAB2 (Stabilin-2)
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    Novus Biologicals STAB2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for STAB2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA12077138
    GO:0009897external side of plasma membrane ISS--

    STAB2 for ontologies           About GeneDecksing



    STAB2 Antibody Products: 
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    Uscn ELISAs and CLIAs for STAB2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    STAB2 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR016187 C-type_lectin_fold
     IPR000742 EG-like_dom
     IPR009030 Growth_fac_rcpt
     IPR016186 C-type_lectin-like
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry Q8WWQ8

    ProtoNet protein and cluster: Q8WWQ8

    5 Blocks protein families:
    IPB000538 Link domain
    IPB000737 Serine protease inhibitor
    IPB000782 Beta-Ig-H3/Fasciclin domain
    IPB002049 Laminin-type EGF-like domain
    IPB013111 EGF


    UniProtKB/Swiss-Prot: STAB2_HUMAN, Q8WWQ8
    Domain: Recognizes phosphatidyl serine via its epidermal growth factor-like domains
    Similarity: Contains 17 EGF-like domains
    Similarity: Contains 7 FAS1 domains
    Similarity: Contains 2 laminin EGF-like domains
    Similarity: Contains 1 Link domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STAB2_HUMAN, Q8WWQ8
    Function: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds
    to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger
    receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated
    low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to
    maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of
    bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment
    in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense
    against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for
    heparin internalisation as well as HA and CS

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005041low-density lipoprotein receptor activity IDA12077138
    GO:0005044scavenger receptor activity IDA12077138
    GO:0005540hyaluronic acid binding ISS--
    GO:0015035protein disulfide oxidoreductase activity NAS12077138
    GO:0030169low-density lipoprotein particle binding IDA12077138
         
    STAB2 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Stab2):
     cardiovascular system  homeostasis/metabolism  liver/biliary system  mortality/aging  muscle 
     normal  renal/urinary system  respiratory system  tumorigenesis 

    STAB2 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Stab2tm1.1Cger for STAB2
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for STAB2 

    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate STAB2 (see all 17):
    hsa-let-7d hsa-miR-202 hsa-miR-513a-5p hsa-miR-128 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-98
    SwitchGear 3'UTR luciferase reporter plasmidSTAB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STAB2 (see all 4)
    OriGene shRNA RFP: STAB2
    OriGene siRNA: STAB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAB2
    Sirion Biotech Custom design and validation of potent shRNA sequences against STAB2 

    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAB2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MPS IIIC - Sanfilippo syndrome C
    8/14 pathways (see all 14)
    MPS IIIC - Sanfilippo syndrome C1.00
    MPS IIIA - Sanfilippo syndrome A1.00
    MPS I - Hurler syndrome1.00
    MPS IIID - Sanfilippo syndrome D1.00
    Mucopolysaccharidoses1.00
    MPS IX - Natowicz syndrome1.00
    MPS IV - Morquio syndrome A1.00
    MPS II - Hunter syndrome1.00
    2Hyaluronan uptake and degradation
    Hyaluronan uptake and degradation1.00
    Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments0.60
    Hyaluronan metabolism0.71
    3Disease
    Disease1.00
    4Metabolism
    Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/19        Reactome Pathways for STAB2 (see all 19)
        Hyaluronan metabolism
    MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    MPS II - Hunter syndrome



    STAB2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STAB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/13 Interacting proteins for STAB2 (Q8WWQ82, 3 ENSP000003735394) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TMSB4XP623282, 3, ENSP000003700074MINT-6542300 I2D: score=1 STRING: ENSP00000370007
    PIAS1O759253, ENSP000002496364I2D: score=1 STRING: ENSP00000249636
    SUMO3P558543, ENSP000003303434I2D: score=1 STRING: ENSP00000330343
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    MAPK1P284823I2D: score=1 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis NAS12077138
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006897endocytosis ISS--
    GO:0006898receptor-mediated endocytosis TAS12077138
    GO:0007155cell adhesion NAS12077138

    STAB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STAB2

    2 HMDB Compounds for STAB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hyaluronanhyaluronic acid (see all 13)9004-61-9--
    Hyaluronic acidhyaluronic acid 9004-61-9--
    Search CenterWatch for drugs/clinical trials and news about STAB2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STAB2 gene: 
    NM_017564.9  

    Unigene Cluster for STAB2:

    Stabilin 2
    Hs.408249  [show with all ESTs]
    Unigene Representative Sequence: NM_017564
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000388887(uc001tjw.3 uc009zug.3) ENST00000549474 ENST00000549798
    ENST00000548073 ENST00000548579 ENST00000552777

    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate STAB2 (see all 17):
    hsa-let-7d hsa-miR-202 hsa-miR-513a-5p hsa-miR-128 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-98
    SwitchGear 3'UTR luciferase reporter plasmidSTAB2 3' UTR sequence
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAB2
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    Additional cDNA sequence: 

    AB052958.1 AF160476.1 AJ295695.1 AK024503.1 AK074051.1 AK160380.1 AL133021.1 AY227444.1 
    AY311388.1 

    5 DOTS entries:

    DT.214106  DT.210667  DT.40279436  DT.214103  DT.205116 

    24/57 AceView cDNA sequences (see all 57):

    AK074051 R97435 AY311388 AI081595 AY227444 AL706559 AB052958 AI084842 
    AA704436 AA845665 CA449310 AA257068 AA010566 CA433190 BX101101 AJ295695 
    AI022302 AI248408 BI832486 NM_017564 AF160476 AA968560 AL133021 AA257161 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for STAB2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                                                                                                        -                                                   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42a · 42b · 42c ^ 43 ^ 44a · 44b ^ 45 ^ 46a · 46b ^ 47 ^
    SP1:                                                                                                  -     -                                               -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                  -                                                         
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for STAB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STAB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGGGTAACT
    STAB2 Expression
    About this image

    STAB2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverSinusoidsSinusoidal Endothelial CellsEndothelium
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium

    See STAB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STAB2

    SOURCE GeneReport for Unigene cluster: Hs.408249

    UniProtKB/Swiss-Prot: STAB2_HUMAN, Q8WWQ8
    Tissue specificity: Highly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also expressed
    in non SEC-cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type 1-associated
    myelopathy), and several macrophage cell line

        SABiosciences Expression via Pathway-Focused PCR Array including STAB2: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for STAB2 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves STAB21 stabilin 2 68.39(n)
    64.92(a)
      418089  XM_003640410.1  XP_003640458.1 
    lizard
    (Anolis carolinensis)
    Reptilia STAB26
    --
    60(a)
    1 ↔ 1
    5(18037398-18120574)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.154332 Transcribed sequence with weak similarity to protein more 75.02(n)    BX717115.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stab26
    zgc:1583286
    zgc:158328
    46(a)
    10(a)
    1 ↔ 1
    possible ortholog
    4(9786319-9828071)
    15(34549798-34617936)


    ENSEMBL Gene Tree for STAB2 (if available)
    TreeFam Gene Tree for STAB2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STAB2 gene
    NAGPA2  STAB12  MEGF102  SCARF22  MEGF62  SCARF12  MEGF112  TNFAIP62  
    PEAR12  
    2 SIMAP similar genes for STAB2 using alignment to 4 protein entries:     STAB2_HUMAN (see all proteins):
    DKFZp434E0321    STAB1

    STAB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3722 NCBI SNPs in STAB2 are shown (see all 3722    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1496115071,2
    Cother104118771(+) GTAGTA/C/GAATTT 3 K Q E mis11NA 4550
    rs733919811,2
    C--103979126(+) ATCTGG/AAGGTT 1 -- us2k12Minor allele frequency- A:0.21WA 120
    rs1895510321,2
    --103979130(+) GGAGGC/TTGCCA 1 -- us2k10--------
    rs1812097121,2
    --103979170(+) CTTAGC/TCTAAA 1 -- us2k10--------
    rs1419802761,2
    --103979237(+) GCGTTG/TTTTTA 1 -- us2k10--------
    rs1854555421,2
    --103979266(+) TCAATG/TGACTA 1 -- us2k10--------
    rs1906591391,2
    --103979494(+) GAAAAC/GAATCA 1 -- us2k10--------
    rs111116651,2
    F,H--103979531(+) GTTATA/CTTTTT 1 -- us2k1 tfbs36Minor allele frequency- C:0.08NS EA NA 636
    rs359290671,2
    C,F--103979628(+) CCAGCG/ACAAGT 1 -- us2k18Minor allele frequency- A:0.19NA WA CSA EA 368
    rs2018979781,2
    --103979724(+) TTAGG-/CCTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for STAB2 (103981051 - 104160505 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for STAB2
         5 CNVs: 76142 47868 86547 76140 86549
         2 Indels: 86548 76141

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    STAB2 for disorders           About GeneDecksing

    OMIM gene information: 608561    OMIM disorders: --

    20/23 diseases for STAB2 (see all 23):    About MalaCards
    crimean-congo hemorrhagic fever    tick-borne encephalitis    la crosse encephalitis    western equine encephalitis
    eastern equine encephalitis    west nile fever    louping ill    tick infestation
    phlebotomus fever    hepatitis    encephalitis    tularemia
    pasteurellosis    hemorrhagic fever    lyme disease    brucellosis
    sinusitis    thrombosis    t-cell leukemia    leukemia

    7 diseases from the University of Copenhagen DISEASES database for STAB2:
    Tularemia     La Crosse encephalitis     Pasteurellosis     West Nile fever
    Brucellosis     Louping ill     Lyme disease
    Human Genome Epidemiology (HuGE) Navigator: STAB2 (2 documents)

    Export disorders for STAB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STAB2 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with STAB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues. (PubMed id 11829752)1, 2, 3, 9 Politz O.... Goerdt S. (2002)
    2. FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities. (PubMed id 12077138)1, 2, 3 Adachi H. and Tsujimoto M. (2002)
    3. The human hyaluronan receptor for endocytosis (HARE/Stabilin-2) is a systemic clearance receptor for heparin. (PubMed id 18434317)1, 2, 9 Harris E.N.... Weigel P.H. (2008)
    4. Rat and human HARE/stabilin-2 are clearance receptors for high- and low-molecular-weight heparins. (PubMed id 19359419)1, 2, 9 Harris E.N.... Weigel P.H. (2009)
    5. Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor. (PubMed id 17962816)1, 2, 9 Park S.Y.... Kim I.S. (2008)
    6. Epidermal growth factor-like domain repeat of stabilin-2 recognizes phosphatidylserine during cell corpse clearance. (PubMed id 18573870)1, 2, 9 Park S.Y....Kim I.S. (2008)
    7. Thymosin beta4 is involved in stabilin-2-mediated apoptotic cell engulfment. (PubMed id 18519035)1, 2, 9 Lee S.J.... Kim I.S. (2008)
    8. Requirement of adaptor protein GULP during stabilin-2-mediated cell corpse engulfment. (PubMed id 18230608)1, 2, 9 Park S.Y....Kim I.S. (2008)
    9. FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products. (PubMed id 12473645)1, 2, 9 Tamura Y.... Ishibashi S. (2003)
    10. Expression, processing, and glycosaminoglycan binding activity of the recombinant human 315-kDa hyaluronic acid receptor for endocytosis (HARE). (PubMed id 17145755)1, 2, 9 Harris E.N.... Weigel P.H. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55576 HGNC: 18629 AceView: STAB2 Ensembl:ENSG00000136011 euGenes: HUgn55576
    ECgene: STAB2 H-InvDB: STAB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STAB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STAB2 gene:
    Search GeneIP for patents involving STAB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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