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STAB2 Gene

protein-coding   GIFtS: 59
GCID: GC12P103981

Stabilin 2

  See STAB2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Stabilin 21 2     FAS1 EGF-Like And X-Link Domain Containing Adhesion Molecule-22
Hyaluronic Acid Receptor For Endocytosis1 2     Fasciclin Egf-Like, Laminin-Type Egf-Like, And Link Domain-Containing
Scavenger Receptor-22
Hyaluronan Receptor For Endocytosis2 3     Hepatic Hyaluronan Clearance Receptor2
FEEL22 3     stabilin-22
FEX22 3     FEEL-23
HARE2 3     FELL3
FELE-22     FAS1 EGF-Like And X-Link Domain-Containing Adhesion Molecule 23
FELL22     Fasciclin, EGF-Like, Laminin-Type EGF-Like And Link Domain-Containing
Scavenger Receptor 23
CD44-Like Precursor FELL2     

External Ids:    HGNC: 186291   Entrez Gene: 555762   Ensembl: ENSG000001360117   OMIM: 6085615   UniProtKB: Q8WWQ83   

Export aliases for STAB2 gene to outside databases

Previous GC identifers: GC12P103079 GC12M9E0035 GC12P103914 GC12P102483 GC12P101040


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STAB2 Gene:
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing,
cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like,
and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein
is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been
shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative
bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the
protein has been shown to cycle between the plasma membrane and lysosomes. (provided by RefSeq, Jul 2008)

GeneCards Summary for STAB2 Gene:
STAB2 (stabilin 2) is a protein-coding gene. Diseases associated with STAB2 include louping ill, and west nile fever. GO annotations related to this gene include hyaluronic acid binding and scavenger receptor activity. An important paralog of this gene is TNFAIP6.

UniProtKB/Swiss-Prot: STAB2_HUMAN, Q8WWQ8
Function: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that
binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic
scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan
(GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products
(AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to
maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important
role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria
and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also
functions as an endocytosis receptor for heparin internalisation as well as HA and CS

Gene Wiki entry for STAB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STAB2 gene promoter:
         c-Fos   AP-1   ATF-2   Meis-1b   YY1   c-Jun   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTAB2 promoter sequence
   Search Chromatin IP Primers for STAB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STAB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.3   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q23.3

STAB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAB2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P103981:  view genomic region     (about GC identifiers)

Start:
103,981,051 bp from pter      End:
104,160,505 bp from pter
Size:
179,455 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STAB2_HUMAN, Q8WWQ8 (See protein sequence)
Recommended Name: Stabilin-2 precursor  
Size: 2551 amino acids; 276988 Da
Subunit: Interacts with GULP1 and heparin. Also interacts with alpha-M/beta-2 integrin (ITGAM and ITGB2) and
thymosin beta 4 (TMSB4X and/or TMSB4Y)
Sequence caution: Sequence=AAF82398.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAD18723.1; Type=Frameshift; Positions=240, 253, 588, 1586;
Secondary accessions: Q6ZMK2 Q7Z5N9 Q86UR4 Q8IUG9 Q8TES1 Q9H7H7 Q9NRY3

Explore the universe of human proteins at neXtProt for STAB2: NX_Q8WWQ8

Explore proteomics data for STAB2 at MOPED

Post-translational modifications: 

  • Glycosylated1
  • Proteolytically processed to yield a 190 kDa protein1
  • Glycosylation2 at Asn133, Asn337, Asn449, Asn619, Asn720, Asn761, Asn847, Asn925, Asn1016, Asn1028,
                                 Asn1100, Asn1247, Asn1275, Asn1367, Asn1429, Asn1437, Asn1465
  • Modification sites at PhosphoSitePlus

  • See STAB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060034.9  
    ENSEMBL proteins: 
     ENSP00000373539   ENSP00000449282   ENSP00000446629  
    Reactome Protein details: Q8WWQ8

    STAB2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for STAB2 (Stabilin-2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for STAB2
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for STAB2
    OriGene Custom Protein Services for STAB2
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    Novus Biologicals STAB2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STAB2

     
    Search eBioscience for Proteins for STAB2 

    STAB2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of STAB2
    R&D Systems Antibodies for STAB2 (Stabilin-2)
    Browse OriGene Antibodies
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    Novus Biologicals STAB2 Antibodies
    Abcam antibodies for STAB2
    Cloud-Clone Corp. Antibodies for STAB2
    Search ThermoFisher Antibodies for STAB2
    LSBio Antibodies in human, mouse, rat for STAB2

    STAB2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STAB2
    Cloud-Clone Corp. CLIAs for STAB2
    Search eBioscience for ELISAs for STAB2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR016187 C-type_lectin_fold
     IPR000742 EG-like_dom
     IPR016186 C-type_lectin-like
     IPR013032 EGF-like_CS
     IPR002049 EGF_laminin

    Graphical View of Domain Structure for InterPro Entry Q8WWQ8

    ProtoNet protein and cluster: Q8WWQ8

    5 Blocks protein domains:
    IPB000538 Link domain
    IPB000737 Serine protease inhibitor
    IPB000782 Beta-Ig-H3/Fasciclin domain
    IPB002049 Laminin-type EGF-like domain
    IPB013111 EGF


    UniProtKB/Swiss-Prot: STAB2_HUMAN, Q8WWQ8
    Domain: Recognizes phosphatidyl serine via its epidermal growth factor-like domains
    Similarity: Contains 17 EGF-like domains
    Similarity: Contains 7 FAS1 domains
    Similarity: Contains 2 laminin EGF-like domains
    Similarity: Contains 1 Link domain


    Find genes that share domains with STAB2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STAB2_HUMAN, Q8WWQ8
    Function: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that
    binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic
    scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan
    (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products
    (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to
    maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important
    role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria
    and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also
    functions as an endocytosis receptor for heparin internalisation as well as HA and CS

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005041low-density lipoprotein receptor activity IDA12077138
    GO:0005044scavenger receptor activity IDA12077138
    GO:0005509calcium ion binding ----
    GO:0005515protein binding IPI18519035
    GO:0005540hyaluronic acid binding ISS--
         
    Find genes that share ontologies with STAB2           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Stab2):
     cardiovascular system  homeostasis/metabolism  liver/biliary system  mortality/aging  muscle 
     normal  renal/urinary system  respiratory system  tumorigenesis 

    Find genes that share phenotypes with STAB2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Stab2tm1.1Cger for STAB2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STAB2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STAB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STAB2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STAB2

    miRNA
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    Block miRNA regulation of human, mouse, rat STAB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STAB2 (see all 17):
    hsa-let-7d hsa-miR-202 hsa-miR-513a-5p hsa-miR-128 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-98
    SwitchGear 3'UTR luciferase reporter plasmidSTAB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STAB2
    Predesigned siRNA for gene silencing in human, mouse, rat STAB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STAB2

    Clone
    Products:
         
    OriGene clones in human, mouse for STAB2 (see all 5)
    OriGene ORF clones in mouse, rat for STAB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STAB2 (NM_017564)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAB2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat STAB2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for STAB2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STAB2_HUMAN, Q8WWQ8: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Only a small amount
    appears to be present at the cell surface
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    mitochondrion2
    chloroplast1
    endoplasmic reticulum1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA12077138
    GO:0009897external side of plasma membrane ISS--
    GO:0030666endocytic vesicle membrane TAS--

    Find genes that share ontologies with STAB2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STAB2 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIID - Sanfilippo syndrome D0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS I - Hurler syndrome0.45
    MPS IV - Morquio syndrome A0.45
    MPS IV - Morquio syndrome B0.45
    MPS IIIA - Sanfilippo syndrome A0.45
    MPS VII - Sly syndrome0.45
    2Binding and Uptake of Ligands by Scavenger Receptors
    Binding and Uptake of Ligands by Scavenger Receptors0.53
    Scavenging by Class H Receptors0.00
    3Metabolism
    Metabolism0.38
    4Disease
    Disease


    Find genes that share SuperPaths with STAB2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for STAB2
        Scavenging by Class H Receptors
    Hyaluronan uptake and degradation


        Pathway & Disease-focused RT2 Profiler PCR Array including STAB2: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for STAB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for STAB2 (Q8WWQ81, 2, 3 ENSP000003735394) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TMSB4XP623282, 3, ENSP000003700074MINT-6542300 I2D: score=1 STRING: ENSP00000370007
    PIAS1O759253, ENSP000002496364I2D: score=1 STRING: ENSP00000249636
    SUMO3P558543, ENSP000003303434I2D: score=1 STRING: ENSP00000330343
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    MAPK1P284823I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis NAS12077138
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006897endocytosis ISS--
    GO:0006898receptor-mediated endocytosis TAS12077138
    GO:0007155cell adhesion NAS12077138

    Find genes that share ontologies with STAB2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STAB2

    2 HMDB Compounds for STAB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hyaluronanhyaluronic acid (see all 13)9004-61-9--
    Hyaluronic acidhyaluronic acid 9004-61-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STAB2 gene: 
    NM_017564.9  

    Unigene Cluster for STAB2:

    Stabilin 2
    Hs.408249  [show with all ESTs]
    Unigene Representative Sequence: NM_017564
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000388887(uc001tjw.3 uc009zug.3) ENST00000549474 ENST00000549798
    ENST00000548073 ENST00000548579 ENST00000552777
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate STAB2 (see all 17):
    hsa-let-7d hsa-miR-202 hsa-miR-513a-5p hsa-miR-128 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-98
    SwitchGear 3'UTR luciferase reporter plasmidSTAB2 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STAB2 (NM_017564)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat STAB2
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STAB2
      QuantiTect SYBR Green Assays in human, mouse, rat STAB2
      QuantiFast Probe-based Assays in human, mouse, rat STAB2

    Additional mRNA sequence: 

    AB052958.1 AF160476.1 AJ295695.1 AK024503.1 AK074051.1 AK160380.1 AL133021.1 AY227444.1 
    AY311388.1 

    5 DOTS entries:

    DT.214106  DT.210667  DT.40279436  DT.214103  DT.205116 

    Selected AceView cDNA sequences (see all 57):

    AA010566 AI084842 CA449310 AB052958 AL706559 AI081595 AA257068 AA704436 
    AY227444 R97435 AK074051 AA845665 AY311388 AI131339 AF160476 NM_017564 
    BI832486 AA968560 AK024503 AI022302 BX101101 AK160380 CA433190 T47505 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for STAB2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                                                                                                        -                                                   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42a · 42b · 42c ^ 43 ^ 44a · 44b ^ 45 ^ 46a · 46b ^ 47 ^
    SP1:                                                                                                  -     -                                               -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                  -                                                         
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for STAB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STAB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGGTAACT
    STAB2 Expression
    About this image


    STAB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Sinusoidal Endothelial Cells Sinusoids
             Liver Lobule
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Sinusoidal Endothelial Cells Sinusoids
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    STAB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STAB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.408249

    UniProtKB/Swiss-Prot: STAB2_HUMAN, Q8WWQ8
    Tissue specificity: Highly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also
    expressed in non SEC-cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type
    1-associated myelopathy), and several macrophage cell line

        Pathway & Disease-focused RT2 Profiler PCR Array including STAB2: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for STAB2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stab21 , 5 stabilin 21, 5 81.18(n)1
    78.47(a)1
      10 (43.14 cM)5
    1921881  NM_138673.21  NP_619614.11 
     868411985 
    chicken
    (Gallus gallus)
    Aves STAB21 stabilin 2 66.84(n)
    63.05(a)
      418089  XM_003640410.2  XP_003640458.2 
    lizard
    (Anolis carolinensis)
    Reptilia STAB26
    stabilin 2
    61(a)
    1 ↔ 1
    5(18037398-18137122)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.154332 Transcribed sequence with weak similarity to protein more 75.02(n)    BX717115.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stab21 stabilin 2 55.38(n)
    49.28(a)
      565194  XM_005164668.1  XP_005164725.1 


    ENSEMBL Gene Tree for STAB2 (if available)
    TreeFam Gene Tree for STAB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STAB2 gene
    TNFAIP62  STAB12  
    2 SIMAP similar genes for STAB2 using alignment to 4 protein entries:     STAB2_HUMAN (see all proteins):
    DKFZp434E0321    STAB1

    Find genes that share paralogs with STAB2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STAB2 (see all 4467)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1496115071,2
    Cuntested1104118771(+) GTAGTA/C/GAATTT 2 K E mis11NA 4550
    rs676306491,2
    C--101078496(+) AAAAA-/AA    
       
    /AAAA
    GGATA
    1 -- int11NA 2
    rs348819891,2
    C--103854455(+) ACACG-/AC/CA 
            
    TGCAC
    1 -- int10--------
    rs675853351,2
    C--103978323(+) TTTTT-/TTTT/ 
     TTTTTTT
    AAGAC
    1 -- int12NA 4
    rs733919811,2
    C,F--103979126(+) ATCTGG/AAGGTT 1 -- us2k12Minor allele frequency- A:0.21WA 120
    rs1895510321,2
    --103979130(+) GGAGGC/TTGCCA 1 -- us2k10--------
    rs1812097121,2
    --103979170(+) CTTAGC/TCTAAA 1 -- us2k10--------
    rs1419802761,2
    --103979237(+) GCGTTG/TTTTTA 1 -- us2k10--------
    rs1854555421,2
    --103979266(+) TCAATG/TGACTA 1 -- us2k10--------
    rs1906591391,2
    --103979494(+) GAAAAC/GAATCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for STAB2 (103981051 - 104160505 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for STAB2 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746295CNV Deletion23290073
    esv2746296CNV Deletion23290073
    esv2746294CNV Deletion23290073
    esv2746298CNV Deletion23290073
    esv997744CNV Deletion20482838
    nsv867CNV Insertion18451855
    esv271377CNV Insertion20981092
    nsv518252CNV Loss19592680
    esv34031CNV Loss18971310
    nsv865CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608561    OMIM disorders: --

    5 diseases for STAB2:    
    About MalaCards
    louping ill    west nile fever    la crosse encephalitis    tularemia
    pasteurellosis

    7 diseases from the University of Copenhagen DISEASES database for STAB2:
    Tularemia     La Crosse encephalitis     West Nile fever     Pasteurellosis
    Brucellosis     Lyme disease     Louping ill

    Find genes that share disorders with STAB2           About GenesLikeMe

    Genetic Association Database (GAD): STAB2
    Human Genome Epidemiology (HuGE) Navigator: STAB2 (2 documents)

    Export disorders for STAB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STAB2 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with STAB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues. (PubMed id 11829752)1, 2, 3, 9 Politz O.... Goerdt S. (Biochem. J. 2002)
    2. FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities. (PubMed id 12077138)1, 2, 3 Adachi H. and Tsujimoto M. (J. Biol. Chem. 2002)
    3. The human hyaluronan receptor for endocytosis (HARE/Stabilin-2) is a systemic clearance receptor for heparin. (PubMed id 18434317)1, 2, 9 Harris E.N.... Weigel P.H. (J. Biol. Chem. 2008)
    4. Rat and human HARE/stabilin-2 are clearance receptors for high- and low-molecular-weight heparins. (PubMed id 19359419)1, 2, 9 Harris E.N.... Weigel P.H. (Am. J. Physiol. 2009)
    5. Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor. (PubMed id 17962816)1, 2, 9 Park S.Y.... Kim I.S. (Cell Death Differ. 2008)
    6. Epidermal growth factor-like domain repeat of stabilin-2 recognizes phosphatidylserine during cell corpse clearance. (PubMed id 18573870)1, 2, 9 Park S.-Y.... Kim I.-S. (Mol. Cell. Biol. 2008)
    7. Thymosin beta4 is involved in stabilin-2-mediated apoptotic cell engulfment. (PubMed id 18519035)1, 2, 9 Lee S.J.... Kim I.S. (FEBS Lett. 2008)
    8. Requirement of adaptor protein GULP during stabilin-2-mediated cell corpse engulfment. (PubMed id 18230608)1, 2, 9 Park S.Y.... Kim I.S. (J. Biol. Chem. 2008)
    9. FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products. (PubMed id 12473645)1, 2, 9 Tamura Y.... Ishibashi S. (J. Biol. Chem. 2003)
    10. Expression, processing, and glycosaminoglycan binding activity of the recombinant human 315-kDa hyaluronic acid receptor for endocytosis (HARE). (PubMed id 17145755)1, 2, 9 Harris E.N.... Weigel P.H. (J. Biol. Chem. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55576 HGNC: 18629 AceView: STAB2 Ensembl:ENSG00000136011 euGenes: HUgn55576
    ECgene: STAB2 H-InvDB: STAB2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STAB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STAB2 gene:
    Search GeneIP for patents involving STAB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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