Aliases for STAB2 Gene
- Stabilin 2 2 3
- Hyaluronic Acid Receptor For Endocytosis 2 3
- Hyaluronan Receptor For Endocytosis 3 4
- FEEL2 3 4
- FEX2 3 4
- HARE 3 4
- Fasciclin Egf-Like, Laminin-Type Egf-Like, And Link Domain-Containing Scavenger Receptor-2 3
- Fasciclin, EGF-Like, Laminin-Type EGF-Like And Link Domain-Containing Scavenger Receptor 2 4
- FAS1 EGF-Like And X-Link Domain Containing Adhesion Molecule-2 3
External Ids for STAB2 Gene
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes. [provided by RefSeq, Jul 2008]
GeneCards Summary for STAB2 Gene
STAB2 (Stabilin 2) is a Protein Coding gene. Diseases associated with STAB2 include louping ill and west nile fever. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include scavenger receptor activity and hyaluronic acid binding. An important paralog of this gene is TNFAIP6.
UniProtKB/Swiss-Prot for STAB2 Gene
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.