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Aliases for STAB2 Gene

Aliases for STAB2 Gene

  • Stabilin 2 2 3
  • Hyaluronic Acid Receptor For Endocytosis 2 3
  • Hyaluronan Receptor For Endocytosis 3 4
  • FEEL2 3 4
  • FEX2 3 4
  • HARE 3 4
  • Fasciclin Egf-Like, Laminin-Type Egf-Like, And Link Domain-Containing Scavenger Receptor-2 3
  • Fasciclin, EGF-Like, Laminin-Type EGF-Like And Link Domain-Containing Scavenger Receptor 2 4
  • FAS1 EGF-Like And X-Link Domain Containing Adhesion Molecule-2 3
  • FAS1 EGF-Like And X-Link Domain-Containing Adhesion Molecule 2 4
  • Hepatic Hyaluronan Clearance Receptor 3
  • CD44-Like Precursor FELL 3
  • FELE-2 3
  • FEEL-2 4
  • FELL2 3
  • FELL 4

External Ids for STAB2 Gene

Previous GeneCards Identifiers for STAB2 Gene

  • GC12P103079
  • GC12M9E0035
  • GC12P103914
  • GC12P102483
  • GC12P101040
  • GC12P103981

Summaries for STAB2 Gene

Entrez Gene Summary for STAB2 Gene

  • This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes. [provided by RefSeq, Jul 2008]

GeneCards Summary for STAB2 Gene

STAB2 (Stabilin 2) is a Protein Coding gene. Diseases associated with STAB2 include louping ill and glandular tularemia. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include calcium ion binding and protein disulfide oxidoreductase activity. An important paralog of this gene is TNFAIP6.

UniProtKB/Swiss-Prot for STAB2 Gene

  • Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.

Gene Wiki entry for STAB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAB2 Gene

Genomics for STAB2 Gene

Regulatory Elements for STAB2 Gene

Genomic Location for STAB2 Gene

Chromosome:
12
Start:
103,587,255 bp from pter
End:
103,766,729 bp from pter
Size:
179,475 bases
Orientation:
Plus strand

Genomic View for STAB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STAB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAB2 Gene

Proteins for STAB2 Gene

  • Protein details for STAB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWQ8-STAB2_HUMAN
    Recommended name:
    Stabilin-2
    Protein Accession:
    Q8WWQ8
    Secondary Accessions:
    • Q6ZMK2
    • Q7Z5N9
    • Q86UR4
    • Q8IUG9
    • Q8TES1
    • Q9H7H7
    • Q9NRY3

    Protein attributes for STAB2 Gene

    Size:
    2551 amino acids
    Molecular mass:
    276988 Da
    Quaternary structure:
    • Interacts with GULP1 and heparin. Also interacts with alpha-M/beta-2 integrin (ITGAM and ITGB2) and thymosin beta 4 (TMSB4X and/or TMSB4Y).
    SequenceCaution:
    • Sequence=AAF82398.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD18723.1; Type=Frameshift; Positions=240, 253, 588, 1586; Evidence={ECO:0000305};

neXtProt entry for STAB2 Gene

Proteomics data for STAB2 Gene at MOPED

Post-translational modifications for STAB2 Gene

  • Glycosylated.
  • Proteolytically processed to yield a 190 kDa protein.
  • Glycosylation at Asn 133, Asn 337, Asn 449, Asn 619, Asn 720, Asn 761, Asn 847, Asn 925, Asn 1016, Asn 1028, Asn 1100, Asn 1247, Asn 1275, Asn 1367, Asn 1429, Asn 1437, Asn 1465, Asn 1573, Asn 1679, Asn 1743, Asn 1993, Asn 2064, Asn 2280, Asn 2296, Asn 2336, Asn 2368, Asn 2382, and Asn 2393
  • Modification sites at PhosphoSitePlus

Other Protein References for STAB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for STAB2 Gene

Domains & Families for STAB2 Gene

Suggested Antigen Peptide Sequences for STAB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWQ8

UniProtKB/Swiss-Prot:

STAB2_HUMAN :
  • Recognizes phosphatidyl serine via its epidermal growth factor-like domains
Domain:
  • Recognizes phosphatidyl serine via its epidermal growth factor-like domains
  • Contains 17 EGF-like domains.
  • Contains 7 FAS1 domains.
  • Contains 2 laminin EGF-like domains.
  • Contains 1 Link domain.
genes like me logo Genes that share domains with STAB2: view

No data available for Gene Families for STAB2 Gene

Function for STAB2 Gene

Molecular function for STAB2 Gene

UniProtKB/Swiss-Prot Function:
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.

Gene Ontology (GO) - Molecular Function for STAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005041 low-density lipoprotein receptor activity IDA 12077138
GO:0005044 scavenger receptor activity IDA 12077138
GO:0005509 calcium ion binding --
GO:0005515 protein binding IPI 18519035
GO:0005540 hyaluronic acid binding ISS --
genes like me logo Genes that share ontologies with STAB2: view
genes like me logo Genes that share phenotypes with STAB2: view

Animal Models for STAB2 Gene

MGI Knock Outs for STAB2:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for STAB2 Gene

Localization for STAB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAB2 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Only a small amount appears to be present at the cell surface.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAB2 Gene COMPARTMENTS Subcellular localization image for STAB2 gene
Compartment Confidence
plasma membrane 5
cytosol 2
mitochondrion 2
chloroplast 1
extracellular 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for STAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 12077138
GO:0009897 external side of plasma membrane ISS --
GO:0030666 endocytic vesicle membrane TAS --
genes like me logo Genes that share ontologies with STAB2: view

Pathways & Interactions for STAB2 Gene

genes like me logo Genes that share pathways with STAB2: view

Pathways by source for STAB2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Lipoprotein Signaling & Cholesterol Metabolism in human,mouse,rat

Gene Ontology (GO) - Biological Process for STAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis NAS 12077138
GO:0005975 carbohydrate metabolic process TAS --
GO:0006897 endocytosis ISS --
GO:0006898 receptor-mediated endocytosis TAS 12077138
GO:0007155 cell adhesion NAS 12077138
genes like me logo Genes that share ontologies with STAB2: view

No data available for SIGNOR curated interactions for STAB2 Gene

Drugs & Compounds for STAB2 Gene

(1) Drugs for STAB2 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronan Approved Pharma Target, binder 328
genes like me logo Genes that share compounds with STAB2: view

Transcripts for STAB2 Gene

Unigene Clusters for STAB2 Gene

Stabilin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STAB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1: -
SP2:
SP3:
SP4:
SP5:

ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42a · 42b · 42c ^ 43 ^ 44a · 44b ^ 45 ^ 46a · 46b ^ 47 ^
SP1: - - -
SP2:
SP3:
SP4: -
SP5:

Relevant External Links for STAB2 Gene

GeneLoc Exon Structure for
STAB2
ECgene alternative splicing isoforms for
STAB2

Expression for STAB2 Gene

mRNA expression in normal human tissues for STAB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STAB2 Gene

This gene is overexpressed in Spleen (x39.7) and Liver (x4.6).

Protein differential expression in normal tissues from HIPED for STAB2 Gene

This gene is overexpressed in Spleen (41.4) and Fetal Liver (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STAB2 Gene



SOURCE GeneReport for Unigene cluster for STAB2 Gene Hs.408249

mRNA Expression by UniProt/SwissProt for STAB2 Gene

Q8WWQ8-STAB2_HUMAN
Tissue specificity: Highly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also expressed in non SEC-cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type 1-associated myelopathy), and several macrophage cell line.
genes like me logo Genes that share expression patterns with STAB2: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for STAB2 Gene

Orthologs for STAB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STAB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STAB2 35
  • 85.51 (n)
  • 84.35 (a)
STAB2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STAB2 35
  • 81.21 (n)
  • 79.34 (a)
STAB2 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stab2 35
  • 81.18 (n)
  • 78.47 (a)
Stab2 16
Stab2 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STAB2 35
  • 99.48 (n)
  • 99.45 (a)
STAB2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stab2 35
  • 81.1 (n)
  • 79.22 (a)
oppossum
(Monodelphis domestica)
Mammalia STAB2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STAB2 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves STAB2 35
  • 66.84 (n)
  • 63.05 (a)
STAB2 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STAB2 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stab2 35
  • 63.42 (n)
  • 60.62 (a)
Str.15433 35
zebrafish
(Danio rerio)
Actinopterygii stab2 35
  • 55.38 (n)
  • 49.28 (a)
stab2 36
  • 48 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9826 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for STAB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STAB2 Gene

ENSEMBL:
Gene Tree for STAB2 (if available)
TreeFam:
Gene Tree for STAB2 (if available)

Paralogs for STAB2 Gene

Paralogs for STAB2 Gene

(2) SIMAP similar genes for STAB2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with STAB2: view

Variants for STAB2 Gene

Sequence variations from dbSNP and Humsavar for STAB2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs696214 -- 103,686,734(-) ATGTG(A/C)ATCAC intron-variant
rs697196 -- 103,599,076(-) AATGA(A/G)CTAGA intron-variant
rs697197 -- 103,614,806(+) GGACA(A/T)TCTAC intron-variant
rs697198 -- 103,617,957(-) TCTCT(C/G)GGGCT intron-variant
rs697199 -- 103,648,958(-) CTCTC(A/G)CCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STAB2 Gene

Variant ID Type Subtype PubMed ID
esv271377 CNV Insertion 20981092
nsv527362 CNV Loss 19592680
nsv865 CNV Loss 18451855
nsv518252 CNV Loss 19592680
nsv525838 CNV Loss 19592680
nsv524064 CNV Loss 19592680
nsv867 CNV Insertion 18451855
nsv899479 CNV Gain 21882294
dgv1486n71 CNV Gain 21882294
esv34031 CNV Loss 18971310
dgv1487n71 CNV Gain 21882294
nsv899486 CNV Gain 21882294
nsv899488 CNV Gain 21882294
esv2746294 CNV Deletion 23290073
esv997744 CNV Deletion 20482838
esv2746295 CNV Deletion 23290073
esv2746296 CNV Deletion 23290073
esv2746298 CNV Deletion 23290073
dgv1488n71 CNV Gain 21882294
dgv1489n71 CNV Gain 21882294

Variation tolerance for STAB2 Gene

Residual Variation Intolerance Score: 95.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.45; 94.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STAB2 Gene

HapMap Linkage Disequilibrium report
STAB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAB2 Gene

Disorders for STAB2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for STAB2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
louping ill
glandular tularemia
la crosse encephalitis
  • california encephalitis
ulceroglandular tularemia
tularemia
  • deerfly fever
- elite association
Search STAB2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for STAB2

Genetic Association Database (GAD)
STAB2
Human Genome Epidemiology (HuGE) Navigator
STAB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STAB2
genes like me logo Genes that share disorders with STAB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STAB2 Gene

Publications for STAB2 Gene

  1. Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues. (PMID: 11829752) Politz O. … Goerdt S. (Biochem. J. 2002) 2 23 25 67
  2. The human hyaluronan receptor for endocytosis (HARE/Stabilin-2) is a systemic clearance receptor for heparin. (PMID: 18434317) Harris E.N. … Weigel P.H. (J. Biol. Chem. 2008) 23 25 67
  3. Expression, processing, and glycosaminoglycan binding activity of the recombinant human 315-kDa hyaluronic acid receptor for endocytosis (HARE). (PMID: 17145755) Harris E.N. … Weigel P.H. (J. Biol. Chem. 2007) 23 25 67
  4. The conserved histidine in epidermal growth factor-like domains of stabilin-2 modulates pH-dependent recognition of phosphatidylserine in apoptotic cells. (PMID: 20382256) Kim S. … Kim I.S. (Int. J. Biochem. Cell Biol. 2010) 23 67
  5. Scavenger receptor collectin placenta 1 (CL-P1) predominantly mediates zymosan phagocytosis by human vascular endothelial cells. (PMID: 19073604) Jang S. … Wakamiya N. (J. Biol. Chem. 2009) 23 67

Products for STAB2 Gene

Sources for STAB2 Gene

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