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Aliases for STAB1 Gene

Aliases for STAB1 Gene

  • Stabilin 1 2 3
  • MS-1 Antigen 2 3 4
  • Fasciclin, EGF-Like, Laminin-Type EGF-Like And Link Domain-Containing Scavenger Receptor 1 3 4
  • Common Lymphatic Endothelial And Vascular Endothelial Receptor-1 2 3
  • FEEL-1 3 4
  • Fasciclin Egf-Like, Laminin-Type Egf-Like, And Link Domain-Containing Scavenger Receptor-1 3
  • And Link Domain-Containing Scavenger Receptor-1 2
  • Laminin-Type Egf-Like 2
  • Fasciclin Egf-Like 2
  • CLEVER-1 3
  • KIAA0246 4
  • FELE-1 3
  • STAB-1 3
  • FEEL1 4
  • FEX1 3

External Ids for STAB1 Gene

Previous GeneCards Identifiers for STAB1 Gene

  • GC03P051621
  • GC03P051781
  • GC03P052385
  • GC03P052487
  • GC03P052504

Summaries for STAB1 Gene

Entrez Gene Summary for STAB1 Gene

  • This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. [provided by RefSeq, Jul 2008]

GeneCards Summary for STAB1 Gene

STAB1 (Stabilin 1) is a Protein Coding gene. Diseases associated with STAB1 include rosai-dorfman disease and histiocytosis. Among its related pathways are Vesicle-mediated transport and Binding and Uptake of Ligands by Scavenger Receptors. GO annotations related to this gene include calcium ion binding and protein disulfide oxidoreductase activity. An important paralog of this gene is STAB2.

UniProtKB/Swiss-Prot for STAB1 Gene

  • Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system.

Gene Wiki entry for STAB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAB1 Gene

Genomics for STAB1 Gene

Regulatory Elements for STAB1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STAB1 Gene

Chromosome:
3
Start:
52,495,338 bp from pter
End:
52,524,495 bp from pter
Size:
29,158 bases
Orientation:
Plus strand

Genomic View for STAB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STAB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAB1 Gene

Proteins for STAB1 Gene

  • Protein details for STAB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY15-STAB1_HUMAN
    Recommended name:
    Stabilin-1
    Protein Accession:
    Q9NY15
    Secondary Accessions:
    • A7E297
    • Q8IUH0
    • Q8IUH1
    • Q93072

    Protein attributes for STAB1 Gene

    Size:
    2570 amino acids
    Molecular mass:
    275482 Da
    Quaternary structure:
    • Interacts with CHID1.
    SequenceCaution:
    • Sequence=BAA13377.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for STAB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAB1 Gene

Proteomics data for STAB1 Gene at MOPED

Post-translational modifications for STAB1 Gene

  • Glycosylation at Asn 133, Asn 286, Asn 312, Asn 413, Asn 606, Asn 673, Asn 712, Asn 745, Asn 816, Asn 1087, Asn 1096, Asn 1170, Asn 1178, Asn 1222, Asn 1274, Asn 1378, Asn 1471, Asn 1626, Asn 1727, Asn 2107, Asn 2222, Asn 2261, Asn 2290, Asn 2334, Asn 2347, Asn 2379, Asn 2393, Asn 2400, and Asn 2424
  • Modification sites at PhosphoSitePlus

Other Protein References for STAB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for STAB1 Gene

Domains & Families for STAB1 Gene

Suggested Antigen Peptide Sequences for STAB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NY15

UniProtKB/Swiss-Prot:

STAB1_HUMAN :
  • Contains 16 EGF-like domains.
Domain:
  • Contains 16 EGF-like domains.
  • Contains 7 FAS1 domains.
  • Contains 2 laminin EGF-like domains.
  • Contains 1 Link domain.
genes like me logo Genes that share domains with STAB1: view

No data available for Gene Families for STAB1 Gene

Function for STAB1 Gene

Molecular function for STAB1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system.

Gene Ontology (GO) - Molecular Function for STAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005041 low-density lipoprotein receptor activity IDA 12077138
GO:0005044 scavenger receptor activity IDA 12077138
GO:0005509 calcium ion binding --
GO:0005515 protein binding IPI 16357325
GO:0005540 hyaluronic acid binding IEA --
genes like me logo Genes that share ontologies with STAB1: view
genes like me logo Genes that share phenotypes with STAB1: view

Animal Models for STAB1 Gene

MGI Knock Outs for STAB1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for STAB1 Gene

Localization for STAB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAB1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAB1 Gene COMPARTMENTS Subcellular localization image for STAB1 gene
Compartment Confidence
plasma membrane 5
endosome 2
extracellular 2
golgi apparatus 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for STAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 12077138
GO:0030666 endocytic vesicle membrane TAS --
genes like me logo Genes that share ontologies with STAB1: view

Pathways & Interactions for STAB1 Gene

genes like me logo Genes that share pathways with STAB1: view

Pathways by source for STAB1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Angiogenic Growth Factors in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat

Interacting Proteins for STAB1 Gene

Gene Ontology (GO) - Biological Process for STAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS 12077138
GO:0006954 inflammatory response IEA --
GO:0007155 cell adhesion NAS 12077138
GO:0007267 cell-cell signaling IDA 12077138
GO:0016525 negative regulation of angiogenesis IMP 12077138
genes like me logo Genes that share ontologies with STAB1: view

No data available for SIGNOR curated interactions for STAB1 Gene

Drugs & Compounds for STAB1 Gene

(1) Drugs for STAB1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronan Approved Pharma 328
genes like me logo Genes that share compounds with STAB1: view

Transcripts for STAB1 Gene

Unigene Clusters for STAB1 Gene

Stabilin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STAB1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 23 ^ 24 ^ 25a · 25b · 25c ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36 ^ 37 ^ 38a · 38b ^ 39a · 39b ^ 40a · 40b ^ 41a · 41b ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 42 ^ 43 ^ 44
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for STAB1 Gene

GeneLoc Exon Structure for
STAB1
ECgene alternative splicing isoforms for
STAB1

Expression for STAB1 Gene

mRNA expression in normal human tissues for STAB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STAB1 Gene

This gene is overexpressed in Spleen (x7.1).

Protein differential expression in normal tissues from HIPED for STAB1 Gene

This gene is overexpressed in Monocytes (9.3) and Stomach (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STAB1 Gene



SOURCE GeneReport for Unigene cluster for STAB1 Gene Hs.301989

mRNA Expression by UniProt/SwissProt for STAB1 Gene

Q9NY15-STAB1_HUMAN
Tissue specificity: High levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial cells.
genes like me logo Genes that share expression patterns with STAB1: view

Protein tissue co-expression partners for STAB1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for STAB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STAB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STAB1 35
  • 85.33 (n)
  • 84.41 (a)
STAB1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STAB1 35
  • 86.01 (n)
  • 85.37 (a)
STAB1 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stab1 35
  • 81.84 (n)
  • 82 (a)
Stab1 16
Stab1 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STAB1 35
  • 99.29 (n)
  • 99.07 (a)
STAB1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stab1 35
  • 81.74 (n)
  • 81.61 (a)
oppossum
(Monodelphis domestica)
Mammalia STAB1 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STAB1 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves STAB1 35
  • 58.69 (n)
  • 52.91 (a)
STAB1 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STAB1 36
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii stab1 35
  • 49.99 (n)
  • 42.24 (a)
stab1 36
  • 41 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for STAB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STAB1 Gene

ENSEMBL:
Gene Tree for STAB1 (if available)
TreeFam:
Gene Tree for STAB1 (if available)

Paralogs for STAB1 Gene

Paralogs for STAB1 Gene

(1) SIMAP similar genes for STAB1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STAB1: view

Variants for STAB1 Gene

Sequence variations from dbSNP and Humsavar for STAB1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs731831 -- 52,502,498(+) GTCCC(A/G)CATCA intron-variant
rs740903 -- 52,514,802(-) TGCAG(A/G)CAGCG reference, synonymous-codon, nc-transcript-variant
rs758800 -- 52,495,250(+) TGATA(C/T)GCAGG upstream-variant-2KB
rs758801 -- 52,502,292(+) GCAGT(A/C)CCTAC intron-variant
rs758802 -- 52,512,100(+) TGGGT(C/G)CTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STAB1 Gene

Variant ID Type Subtype PubMed ID
nsv876789 CNV Loss 21882294
nsv834697 CNV Loss 17160897
dgv5137n71 CNV Loss 21882294
nsv3820 CNV Insertion 18451855
esv2725277 CNV Deletion 23290073
dgv5138n71 CNV Loss 21882294

Variation tolerance for STAB1 Gene

Residual Variation Intolerance Score: 19.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.41; 90.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STAB1 Gene

HapMap Linkage Disequilibrium report
STAB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAB1 Gene

Disorders for STAB1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for STAB1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
rosai-dorfman disease
  • rdd
histiocytosis
  • hand schuller christian disease
- elite association
Search STAB1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for STAB1

Genetic Association Database (GAD)
STAB1
Human Genome Epidemiology (HuGE) Navigator
STAB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STAB1
genes like me logo Genes that share disorders with STAB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STAB1 Gene

Publications for STAB1 Gene

  1. Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues. (PMID: 11829752) Politz O. … Goerdt S. (Biochem. J. 2002) 2 23 67
  2. Adaptor protein sorting nexin 17 interacts with the scavenger receptor FEEL-1/stabilin-1 and modulates its expression on the cell surface. (PMID: 20226821) Adachi H. … Tsujimoto M. (Biochim. Biophys. Acta 2010) 23 67
  3. Interactions between advanced glycation end-products (AGE) and their receptors in the development and progression of diabetic nephropathy - are these receptors valid therapeutic targets. (PMID: 19149535) Sourris K.C. … Forbes J.M. (Curr Drug Targets 2009) 23 67
  4. A case of cutaneous Rosai-Dorfman disease refractory to imatinib therapy. (PMID: 19451502) Gebhardt C. … Treudler R. (Arch Dermatol 2009) 23 67
  5. Cross-talk between endocytic clearance and secretion in macrophages. (PMID: 19457577) Kzhyshkowska J. … Krusell L. (Immunobiology 2009) 23 67

Products for STAB1 Gene

Sources for STAB1 Gene

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