Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



STAB1 Gene

protein-coding   GIFtS: 61
GCID: GC03P052529

Stabilin 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Stabilin 11 2     CLEVER-12
MS-1 Antigen1 2 3     FELE-12
Common Lymphatic Endothelial And Vascular Endothelial Receptor-11 2     FEX12
Fasciclin, EGF-Like, Laminin-Type EGF-Like And Link Domain-Containing
Scavenger Receptor 12 3
     STAB-12
FEEL-12 3     Fasciclin Egf-Like, Laminin-Type Egf-Like, And Link Domain-Containing
Scavenger Receptor-12
And Link Domain-Containing Scavenger Receptor-11     stabilin-12
Fasciclin Egf-Like1     FEEL13
Laminin-Type Egf-Like1     KIAA02463

External Ids:    HGNC: 186281   Entrez Gene: 231662   Ensembl: ENSG000000103277   OMIM: 6085605   UniProtKB: Q9NY153   

Export aliases for STAB1 gene to outside databases

Previous GC identifers: GC03P051621 GC03P051781 GC03P052385 GC03P052487 GC03P052504


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for STAB1 Gene:
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing,
cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like,
and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein
is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been
shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and
advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly
cycles between the plasma membrane and early endosomes. (provided by RefSeq, Jul 2008)

GeneCards Summary for STAB1 Gene:
STAB1 (stabilin 1) is a protein-coding gene. Diseases associated with STAB1 include juvenile xanthogranuloma, and rosai-dorfman disease. GO annotations related to this gene include hyaluronic acid binding and scavenger receptor activity. An important paralog of this gene is TNFAIP6.

UniProtKB/Swiss-Prot: STAB1_HUMAN, Q9NY15
Function: Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and
Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial
tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis.
Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the
endosomal/lysosomal system

Gene Wiki entry for STAB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STAB1 gene promoter:
         Max1   GR   NF-1   NF-1/L   Nkx2-5   Arnt   C/EBPalpha   YY1   N-Myc   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTAB1 promoter sequence
   Search Chromatin IP Primers for STAB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STAB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.1   Ensembl cytogenetic band:  3p21.1   HGNC cytogenetic band: 3p21.31

STAB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAB1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P052529:  view genomic region     (about GC identifiers)

Start:
52,529,354 bp from pter      End:
52,558,511 bp from pter
Size:
29,158 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: STAB1_HUMAN, Q9NY15 (See protein sequence)
Recommended Name: Stabilin-1 precursor  
Size: 2570 amino acids; 275482 Da
Subunit: Interacts with CHID1
Sequence caution: Sequence=BAA13377.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A7E297 Q8IUH0 Q8IUH1 Q93072
Alternative splicing: 2 isoforms:  Q9NY15-1   Q9NY15-2   

Explore the universe of human proteins at neXtProt for STAB1: NX_Q9NY15

Explore proteomics data for STAB1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn133, Asn286, Asn312, Asn413, Asn606, Asn673, Asn712, Asn745, Asn816, Asn1087,
                                 Asn1096, Asn1170, Asn1178, Asn1222, Asn1274, Asn1378, Asn1471, Asn1626, Asn1727, Asn2107 (see all 29)
  • Modification sites at PhosphoSitePlus

  • See STAB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055951.2  
    ENSEMBL proteins: 
     ENSP00000312946   ENSP00000418426  
    Reactome Protein details: Q9NY15

    STAB1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for STAB1
    GenScript Custom Purified and Recombinant Proteins Services for STAB1
    Novus Biologicals STAB1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STAB1

    STAB1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of STAB1
    R&D Systems Antibodies for STAB1 (Stabilin-1)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for STAB1
    Novus Biologicals STAB1 Antibodies
    Abcam antibodies for STAB1
    Cloud-Clone Corp. Antibodies for STAB1
    Search ThermoFisher Antibodies for STAB1
    LSBio Antibodies in human, mouse, rat for STAB1

    STAB1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STAB1
    R&D Systems Proteome Profiler Antibody Arrays for STAB1 (Stabilin-1)
    GenScript Custom Assay Services for STAB1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STAB1
    Cloud-Clone Corp. CLIAs for STAB1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 9):
     IPR016187 C-type_lectin_fold
     IPR000742 EG-like_dom
     IPR016186 C-type_lectin-like
     IPR013032 EGF-like_CS
     IPR002049 EGF_laminin

    Graphical View of Domain Structure for InterPro Entry Q9NY15

    ProtoNet protein and cluster: Q9NY15

    2 Blocks protein domains:
    IPB000538 Link domain
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: STAB1_HUMAN, Q9NY15
    Similarity: Contains 16 EGF-like domains
    Similarity: Contains 7 FAS1 domains
    Similarity: Contains 2 laminin EGF-like domains
    Similarity: Contains 1 Link domain


    STAB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STAB1_HUMAN, Q9NY15
    Function: Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and
    Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial
    tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis.
    Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the
    endosomal/lysosomal system

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005041low-density lipoprotein receptor activity IDA12077138
    GO:0005044scavenger receptor activity IDA12077138
    GO:0005509calcium ion binding ----
    GO:0005515protein binding IPI16357325
    GO:0005540hyaluronic acid binding IEA--
         
    STAB1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for STAB1:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Stab1):
     cardiovascular system  homeostasis/metabolism  liver/biliary system  mortality/aging  muscle 
     normal  renal/urinary system  respiratory system 

    STAB1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Stab1tm1.1Cger for STAB1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STAB1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STAB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STAB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STAB1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat STAB1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate STAB1:
    hsa-miR-548t
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STAB1
    Predesigned siRNA for gene silencing in human, mouse, rat STAB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STAB1

    Clone
    Products:
         
    OriGene clones in human, mouse for STAB1 (see all 5)
    OriGene ORF clones in mouse, rat for STAB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STAB1 (NM_015136)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAB1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat STAB1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STAB1
    Browse ESI BIO Cell Lines and PureStem Progenitors for STAB1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    STAB1_HUMAN, Q9NY15: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endosome2
    extracellular2
    cytosol1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA12077138
    GO:0030666endocytic vesicle membrane TAS--

    STAB1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for STAB1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Binding and Uptake of Ligands by Scavenger Receptors
    Binding and Uptake of Ligands by Scavenger Receptors0.53
    Scavenging by Class H Receptors0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for STAB1
        Scavenging by Class H Receptors



    STAB1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including STAB1: 
              Angiogenic Growth Factors in human mouse rat
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for STAB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for STAB1 (Q9NY152, 3 ENSP000003129464) via UniProtKB, MINT, STRING, and/or I2D (see all 561)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GULP1Q9UBP92, 3MINT-7947479 I2D: score=1 
    CHID1Q9BWS93, ENSP000003388384I2D: score=1 STRING: ENSP00000338838
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    MEF2DQ148143I2D: score=2 
    SPARCP094863I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006898receptor-mediated endocytosis TAS12077138
    GO:0006954inflammatory response IEA--
    GO:0007155cell adhesion NAS12077138
    GO:0007267cell-cell signaling IDA12077138
    GO:0016525negative regulation of angiogenesis IMP12077138

    STAB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STAB1

    1 HMDB Compound for STAB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hyaluronic acidhyaluronic acid 9004-61-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for STAB1 gene: 
    NM_015136.2  

    Unigene Cluster for STAB1:

    Stabilin 1
    Hs.301989  [show with all ESTs]
    Unigene Representative Sequence: BC150250
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000321725(uc003dej.3) ENST00000481607(uc003dei.1) ENST00000479355
    ENST00000484850 ENST00000461325 ENST00000481626(uc003dek.1) ENST00000462741(uc003del.3)
    ENST00000462681 ENST00000469989
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STAB1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate STAB1:
    hsa-miR-548t
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STAB1
    Predesigned siRNA for gene silencing in human, mouse, rat STAB1
    Clone
    Products:
         
    OriGene clones in human, mouse for STAB1 (see all 5)
    OriGene ORF clones in mouse, rat for STAB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STAB1 (NM_015136)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAB1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat STAB1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for STAB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STAB1
      QuantiTect SYBR Green Assays in human, mouse, rat STAB1
      QuantiFast Probe-based Assays in human, mouse, rat STAB1

    Additional mRNA sequence: 

    AB052956.1 AB052957.1 AJ275213.1 AK310105.1 BC150250.1 D87433.2 DQ786774.1 HQ013242.1 

    18 DOTS entries:

    DT.100821315  DT.95080636  DT.118715  DT.40117496  DT.100821311  DT.95254242  DT.120869727  DT.86859449 
    DT.120869666  DT.120869894  DT.95200006  DT.100030653  DT.100030656  DT.100744942  DT.95080639  DT.99966746 
    DT.100821306  DT.97855537 

    Selected AceView cDNA sequences (see all 189):

    BQ710692 CK904683 CA396054 BI039282 AW136525 BM664904 BF991012 BM767207 
    BQ711099 BQ012782 BM769766 CA390643 BI038206 BM843258 BI039684 BI769106 
    BM702217 BI038867 AB052957 AW839650 D87433 BM769767 BI039773 AW838103 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STAB1 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^
    SP1:                    -                                                                                                                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25a · 25b · 25c ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36 ^ 37 ^ 38a · 38b ^ 39a · 39b ^ 40a · 40b ^ 41a · 41b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 42 ^ 43 ^ 44
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for STAB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    STAB1 expression in normal human tissues (normalized intensities)      STAB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCACCAAAAA
    STAB1 Expression
    About this image


    STAB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Sinusoidal Endothelial Cells Sinusoids
             Endothelial-like cells
     
     Adipose (Muscoskeletal System)
             Stromal Vascular Preadipocyte Progenitor Cells Vascular Adipose
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
     
     Liver (Hepatobiliary System)
             Sinusoidal Endothelial Cells Sinusoids
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
    STAB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STAB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.301989

    UniProtKB/Swiss-Prot: STAB1_HUMAN, Q9NY15
    Tissue specificity: High levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial
    cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including STAB1: 
              Angiogenic Growth Factors in human mouse rat
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for STAB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STAB1
    QuantiTect SYBR Green Assays in human, mouse, rat STAB1
    QuantiFast Probe-based Assays in human, mouse, rat STAB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for STAB1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stab11 , 5 stabilin 11, 5 81.84(n)1
    82(a)1
      14 (19.09 cM)5
    1921871  NM_138672.21  NP_619613.21 
     311390135 
    chicken
    (Gallus gallus)
    Aves STAB11 stabilin 1 58.69(n)
    52.91(a)
      415894  XM_414246.4  XP_414246.4 
    lizard
    (Anolis carolinensis)
    Reptilia STAB16
    stabilin 1
    49(a)
    1 ↔ 1
    2(154607397-154743767)
    zebrafish
    (Danio rerio)
    Actinopterygii stab11 stabilin 1 49.99(n)
    42.24(a)
      570626  NM_001195614.1  NP_001182543.1 


    ENSEMBL Gene Tree for STAB1 (if available)
    TreeFam Gene Tree for STAB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for STAB1 gene
    TNFAIP62  STAB22  
    1 SIMAP similar gene for STAB1 using alignment to 2 protein entries:     STAB1_HUMAN (see all proteins):
    STAB2

    STAB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for STAB1 (see all 1162)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476770251,2
    --52527622(+) CCCATC/TTGTGT 1 -- us2k10--------
    rs1491435151,2
    --52527633(+) CTGTCA/TTCATG 1 -- us2k10--------
    rs1811640841,2
    --52527738(+) CACACA/TCTTCC 1 -- us2k10--------
    rs98155591,2
    C,F,H--52527915(+) CGTTTC/TCCTTG 1 -- us2k14Minor allele frequency- T:0.01NS EA 418
    rs569660361,2
    C,F--52527963(+) CACCCC/TCAGGA 1 -- us2k12Minor allele frequency- T:0.16CSA WA 120
    rs1483269291,2
    --52527976(+) ACTGTA/GGGTGT 1 -- us2k10--------
    rs67874931,2
    C,A--52528000(+) AGGGTC/TTCCCC 1 -- us2k111Minor allele frequency- T:0.02NA WA CSA EA 371
    rs1856180811,2
    --52528001(+) GGGTTC/TCCCCT 1 -- us2k10--------
    rs1412524151,2
    --52528009(+) CCTTGC/GAACCC 1 -- us2k10--------
    rs1162018081,2
    F--52528120(+) AAAGCA/GTTTAC 1 -- us2k11Minor allele frequency- G:0.01WA 118

    HapMap Linkage Disequilibrium report for STAB1 (52529354 - 52558511 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for STAB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725277CNV Deletion23290073
    nsv3820CNV Insertion18451855
    dgv5137n71CNV Loss21882294
    nsv834697CNV Loss17160897
    nsv876789CNV Loss21882294
    dgv5138n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STAB1
    DNA2.0 Custom Variant and Variant Library Synthesis for STAB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608560    OMIM disorders: --

    17 diseases for STAB1:    About MalaCards
    juvenile xanthogranuloma    rosai-dorfman disease    endotheliitis    familial hypercholesterolemia
    histiocytosis    hypercholesterolemia    acquired immunodeficiency syndrome    sinusitis
    diabetic nephropathy    atherosclerosis    parkinson's disease    bipolar disorder
    schizophrenia    rheumatoid arthritis    arthritis    hepatitis
    breast cancer


    STAB1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for STAB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    histiocytosis 72.5 1 17229202 (1)
    skin lesion 44.1 2 8494045 (2)
    inflammation 27.9 5 12616502 (2), 19953586 (1), 15297319 (1)
    atherosclerosis 14.8 2 20226821 (1), 12473645 (1)
    tumors 0 2 16989725 (1), 15345716 (1)

    Genetic Association Database (GAD): STAB1
    Human Genome Epidemiology (HuGE) Navigator: STAB1 (2 documents)

    Export disorders for STAB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for STAB1 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with STAB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues. (PubMed id 11829752)1, 2, 3, 9 Politz O.... Goerdt S. (Biochem. J. 2002)
    2. FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities. (PubMed id 12077138)1, 2, 3 Adachi H. and Tsujimoto M. (J. Biol. Chem. 2002)
    3. Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up- regulated in alternatively activated macrophages and secreted via lysosomal pathway. (PubMed id 16357325)1, 2, 9 Kzhyshkowska J.... Goerdt S. (Blood 2006)
    4. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    6. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T.... Nomura N. (DNA Res. 1996)
    7. Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors. (PubMed id 15345724)1, 9 Kzhyshkowska J....Goerdt S. (J. Leukoc. Biol. 2004)
    8. CLEVER-1 mediates lymphocyte transmigration through vascular and lymphatic endothelium. (PubMed id 15297319)1, 9 Salmi M....Jalkanen S. (Blood 2004)
    9. A novel GGA-binding site is required for intracellular sorting mediated by stabilin-1. (PubMed id 19752197)1, 9 Zhang J....Kzhyshkowska J. (Mol. Cell. Biol. 2009)
    10. Rapid plasma membrane-endosomal trafficking of the lymph node sinus and high endothelial venule scavenger receptor/homing receptor stabilin-1 (FEEL-1/CLEVER-1). (PubMed id 15345716)1, 9 Prevo R....Jackson D.G. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23166 HGNC: 18628 AceView: STAB1 Ensembl:ENSG00000010327 euGenes: HUgn23166
    ECgene: STAB1 H-InvDB: STAB1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0246

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for STAB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for STAB1 gene:
    Search GeneIP for patents involving STAB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of STAB1
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for STAB1 (Stabilin-1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for STAB1 (Stabilin-1)  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for STAB1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for STAB1  
     OriGene qSTAR qPCR primer pairs in human, mouse for STAB1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for STAB1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for STAB1   OriGene Custom Protein Services for STAB1  

     
     
     Block miRNA regulation of human, mouse, rat STAB1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing STAB1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STAB1 Predesigned siRNA for gene silencing in human, mouse, rat STAB1
     QuantiFast Probe-based Assays in human, mouse, rat STAB1 QuantiTect SYBR Green Assays in human, mouse, rat STAB1
     PCR Arrays including human, mouse, rat STAB1 Search Chromatin IP Primers for STAB1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STAB1  GeneGlobe Interaction Network for STAB1
     Regulatory tfbs in STAB1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for STAB1 GenScript cDNA clones with any tag delivered in your preferred vector for STAB1
     GenScript Custom Assay Services for STAB1 GenScript Custom overexpressing Cell Line Services for STAB1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for STAB1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     STAB1 antibodies
     STAB1 proteins
     Antibodies for STAB1
     See all of Abcam's Antibodies, Kits and Proteins for STAB1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for STAB1
     Antibodies for STAB1
     ELISAs for STAB1
     CLIAs for STAB1



     Browse ESI BIO Cell Lines and PureStem Progenitors for STAB1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAB1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for STAB1
     SwitchGear Promoter luciferase reporter plasmids for STAB1
     Search ThermoFisher Antibodies for STAB1
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat STAB1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STAB1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STAB1
     LSBio Antibodies in human, mouse, rat for STAB1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      STAB1 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4