Aliases for STAB1 Gene
- Stabilin 1 2 3
- MS-1 Antigen 2 3 4
- Fasciclin, EGF-Like, Laminin-Type EGF-Like And Link Domain-Containing Scavenger Receptor 1 3 4
- Common Lymphatic Endothelial And Vascular Endothelial Receptor-1 2 3
- FEEL-1 3 4
- Fasciclin Egf-Like, Laminin-Type Egf-Like, And Link Domain-Containing Scavenger Receptor-1 3
- And Link Domain-Containing Scavenger Receptor-1 2
- Laminin-Type Egf-Like 2
- Fasciclin Egf-Like 2
External Ids for STAB1 Gene
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. [provided by RefSeq, Jul 2008]
GeneCards Summary for STAB1 Gene
STAB1 (Stabilin 1) is a Protein Coding gene. Diseases associated with STAB1 include rosai-dorfman disease and juvenile xanthogranuloma. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Binding and Uptake of Ligands by Scavenger Receptors. GO annotations related to this gene include scavenger receptor activity and hyaluronic acid binding. An important paralog of this gene is STAB2.
UniProtKB/Swiss-Prot for STAB1 Gene
Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system.