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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

STAB1 Gene

protein-coding GIFtS: 56
GCID: GC03P052529

stabilin 1

Explore 15 diseases affiliated with
STAB1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Stabilin 1¹ ²		Fasciclin, EGF-Like, Laminin-Type EGF-Like And Link Domain-Containing Scavenger Receptor 1² ³
FEEL-1¹ ² ³		MS-1 Antigen² ³
CLEVER-1¹ ²		Common Lymphatic Endothelial And Vascular Endothelial Receptor-1²
FELE-1¹ ²		Fasciclin Egf-Like, Laminin-Type Egf-Like, And Link Domain-Containing Scavenger Receptor-1²
FEX1¹ ²		Stabilin-1¹
STAB-1¹ ²		FEEL1³
KIAA0246¹ ³

External Ids:	HGNC: 18628¹	Entrez Gene: 23166²	Ensembl: ENSG00000010327⁷	OMIM: 608560⁵	UniProtKB: Q9NY15³

ORGUL members:
	NONCODE:n339368

Export aliases for STAB1 gene to outside databases

Previous GC identifers: GC03P051621 GC03P051781 GC03P052385 GC03P052487 GC03P052504

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STAB1:

This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell

adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2

laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily

expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose

ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end

products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane

and early endosomes. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: STAB1_HUMAN, Q9NY15

Function: Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and

Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube

formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in

the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system

Gene Wiki entry for STAB1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the STAB1 gene promoter:
Max1 GR NF-1 NF-1/L Nkx2-5 Arnt C/EBPalpha YY1 N-Myc GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STAB1 promoter sequence

Search SABiosciences Chromatin IP Primers for STAB1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAB1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.1 Ensembl cytogenetic band: 3p21.1 HGNC cytogenetic band: 3p21.31

STAB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAB1 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P052529: view genomic region (about GC identifiers)

Start:	52,529,354 bp from pter	End:	52,558,511 bp from pter
Size:	29,158 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: STAB1_HUMAN, Q9NY15 (See protein sequence)

Recommended Name: Stabilin-1 precursor

Size: 2570 amino acids; 275482 Da

Subunit: Interacts with CHID1

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Sequence caution: Sequence=BAA13377.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: A7E297 Q8IUH0 Q8IUH1 Q93072

Alternative splicing: 2 isoforms: Q9NY15-1 Q9NY15-2

Explore the universe of human proteins at neXtProt for STAB1: NX_Q9NY15

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NY15

STAB1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055951.2

ENSEMBL proteins:

ENSP00000312946 ENSP00000418426

Human Recombinant Protein Products for STAB1:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals STAB1 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for STAB1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	IDA	12077138

STAB1 for ontologies About GeneDecksing

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	Search ThermoFisher Antibodies for STAB1

Assay Products for STAB1:

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	Uscn ELISAs and CLIAs for STAB1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

STAB1 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR016187 C-type_lectin_fold

IPR000742 EG-like_dom

IPR016186 C-type_lectin-like

IPR013032 EGF-like_CS

IPR002049 EGF_laminin

Graphical View of Domain Structure for InterPro Entry Q9NY15

ProtoNet protein and cluster: Q9NY15

2 Blocks protein families:

IPB000538 Link domain

IPB006210 Type I EGF

UniProtKB/Swiss-Prot: STAB1_HUMAN, Q9NY15

Similarity: Contains 16 EGF-like domains

Similarity: Contains 7 FAS1 domains

Similarity: Contains 2 laminin EGF-like domains

Similarity: Contains 1 Link domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: STAB1_HUMAN, Q9NY15

Function: Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and

Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube

formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in

the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005041	low-density lipoprotein receptor activity	IDA	12077138
GO:0005044	scavenger receptor activity	IDA	12077138
GO:0005540	hyaluronic acid binding	IEA	--
GO:0015035	protein disulfide oxidoreductase activity	NAS	12077138
GO:0030169	low-density lipoprotein particle binding	IDA	12077138

STAB1 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for STAB1:

Decreased influenza A H1N1 (A/

Decreased influenza A/WSN/33 r

8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Stab1):

cardiovascular system	homeostasis/metabolism	liver/biliary system	mortality/aging	muscle
normal	renal/urinary system	respiratory system

STAB1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Stab1^tm1.1Cger for STAB1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for STAB1

miRNA Products:		OriGene 3'-UTR Clone: STAB1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STAB1
		1 QIAGEN miScript miRNA Assays for microRNA that regulate STAB1:
		hsa-miR-548t
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STAB1 (see all 3) Browse OriGene siRNA
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		Sirion Biotech Custom design and validation of potent shRNA sequences against STAB1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for STAB1
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAB1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAB1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: STAB1 (NM_015136)
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		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat STAB1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for STAB1
		Search LifeMap BioReagents cell lines for STAB1
		Sirion Biotech Customized stable knockdown cell line services for STAB1 Sirion Biotech Customized inducible knockdown cell line services for STAB1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAB1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for STAB1

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/533 Interacting proteins for STAB1 (Q9NY15^{2, 3} ENSP00000312946⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 533)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GULP1	Q9UBP9²^,³	MINT-7947479 I2D: score=1
CHID1	Q9BWS9³, ENSP00000338838⁴	I2D: score=1 STRING: ENSP00000338838
CDC5L	Q99459², ENSP00000360532⁴	MINT-7947479 STRING: ENSP00000360532
MEF2D	Q14814³	I2D: score=2
SPARC	P09486³	I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006898	receptor-mediated endocytosis	TAS	12077138
GO:0006954	inflammatory response	IEA	--
GO:0007155	cell adhesion	NAS	12077138
GO:0007267	cell-cell signaling	IDA	12077138
GO:0016525	negative regulation of angiogenesis	IMP	12077138

STAB1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for STAB1

1 HMDB Compound for STAB1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Hyaluronic acid	hyaluronic acid	9004-61-9	--

Search CenterWatch for drugs/clinical trials and news about STAB1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for STAB1 gene:

NM_015136.2

Unigene Cluster for STAB1:

Stabilin 1

Hs.301989 [show with all ESTs]

Unigene Representative Sequence: BC150250

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000321725(uc003dej.3) ENST00000481607(uc003dei.1) ENST00000479355

ENST00000484850 ENST00000461325 ENST00000481626(uc003dek.1) ENST00000462741(uc003del.3)

ENST00000462681 ENST00000469989

miRNA Products:		OriGene 3'-UTR Clone: STAB1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STAB1
		1 QIAGEN miScript miRNA Assays for microRNA that regulate STAB1:
		hsa-miR-548t
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: STAB1 (NM_015136)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAB1
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STAB1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat STAB1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAB1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAB1

Additional cDNA sequence:

AB052956.1 AB052957.1 AJ275213.1 AK310105.1 BC150250.1 D87433.2 DQ786774.1 HQ013242.1

18 DOTS entries:

DT.100821315 DT.95080636 DT.118715 DT.40117496 DT.100821311 DT.95254242 DT.120869727 DT.86859449

DT.120869666 DT.120869894 DT.95200006 DT.100030653 DT.100030656 DT.100744942 DT.95080639 DT.99966746

DT.100821306 DT.97855537

24/189 AceView cDNA sequences (see all 189):

BI039282 BF991012 BM767207 BM769766 CK904683 BM843258 BI038206 BQ012782

AB052957 BQ711099 CA390643 BM664904 BQ710692 CA396054 AW136525 BI039684

BI769106 BM702217 BI038867 AW839650 D87433 AI656424 BQ446442 BI518863

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for STAB1 (see all 12) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20a	·	20b	^	21a	·	21b	^	22	^
SP1:							-
SP2:
SP3:
SP4:
SP5:

ExUns:	23	^	24	^	25a	·	25b	·	25c	^	26	^	27	^	28	^	29	^	30	^	31	^	32	^	33	^	34	^	35a	·	35b	^	36	^	37	^	38a	·	38b	^	39a	·	39b	^	40a	·	40b	^	41a	·	41b	^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	42	^	43	^	44
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for STAB1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

STAB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCACCAAAAA

About this image

STAB1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Vascular Adipose

Stromal Vascular Preadipocyte Progenitor Cells

Adipose

Liver

Sinusoids

Sinusoidal Endothelial Cells

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

See STAB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STAB1

SOURCE GeneReport for Unigene cluster: Hs.301989

UniProtKB/Swiss-Prot: STAB1_HUMAN, Q9NY15

Tissue specificity: High levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial cells

SABiosciences Expression via Pathway-Focused PCR Arrays including STAB1:

Angiogenic Growth Factors in human mouse rat

Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAB1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAB1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for STAB1 gene from 2/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	STAB1¹	stabilin 1	58.88(n) 53.12(a)		415894 XM_414246.3 XP_414246.3
zebrafish (Danio rerio)	Actinopterygii	stab1l¹	stabilin 1-like	49.98(n) 42.44(a)		570626 NM_001195614.1 NP_001182543.1

ENSEMBL Gene Tree for STAB1 (if available)
TreeFam Gene Tree for STAB1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for STAB1 gene

NAGPA² STAB2² MEGF10² SCARF2² MEGF6² SCARF1² MEGF11² TNFAIP6²

PEAR1²

1 SIMAP similar gene for STAB1 using alignment to 2 protein entries: STAB1_HUMAN (see all proteins):

STAB2

STAB1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147677025^1,2		--	52527622(+)	`CCCATC/TTGTGT`	1	--	us2k¹		0	--	--	--	--
rs149143515^1,2		--	52527633(+)	`CTGTCA/TTCATG`	1	--	us2k¹		0	--	--	--	--
rs181164084^1,2		--	52527738(+)	`CACACA/TCTTCC`	1	--	us2k¹		0	--	--	--	--
rs9815559^1,2	C,F,H	--	52527915(+)	`CGTTTC/TCCTTG`	1	--	us2k¹		4		NS EA	418
rs56966036^1,2		--	52527963(+)	`CACCCC/TCAGGA`	1	--	us2k¹		2		CSA WA	120
rs148326929^1,2		--	52527976(+)	`ACTGTA/GGGTGT`	1	--	us2k¹		0	--	--	--	--
rs6787493^1,2	C,A	--	52528000(+)	`AGGGTC/TTCCCC`	1	--	us2k¹		11		NA WA CSA EA	371
rs185618081^1,2		--	52528001(+)	`GGGTTC/TCCCCT`	1	--	us2k¹		0	--	--	--	--
rs141252415^1,2		--	52528009(+)	`CCTTGC/GAACCC`	1	--	us2k¹		0	--	--	--	--
rs116201808^1,2		--	52528120(+)	`AAAGCA/GTTTAC`	1	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for STAB1 (52529354 - 52558511 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for STAB1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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STAB1 for disorders           About GeneDecksing

OMIM gene information: 608560    OMIM disorders: --

15 diseases for STAB1:    About MalaCards

rosai-dorfman disease juvenile xanthogranuloma histiocytosis familial hypercholesterolemia

hypercholesterolemia rheumatoid arthritis nephropathy parkinson's disease

sinusitis arthritis breast cancer cholesterol

schizophrenia hepatitis malaria

5 Novoseek disease relationships for STAB1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
histiocytosis	72.5	1	17229202 (1)
skin lesion	44.1	2	8494045 (2)
inflammation	27.9	5	12616502 (2), 19953586 (1), 15297319 (1)
atherosclerosis	14.8	2	20226821 (1), 12473645 (1)
tumors	0	2	16989725 (1), 15345716 (1)

Human Genome Epidemiology (HuGE) Navigator: STAB1 (2 documents)

Export disorders for STAB1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for STAB1 gene, integrated from 9 sources (see all 49):
(articles sorted by number of sources associating them with STAB1)

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Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues. (PubMed id 11829752)^{1, 2, 3, 9} Politz O.... Goerdt S. (2002)
FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities. (PubMed id 12077138)^{1, 2, 3} Adachi H. and Tsujimoto M. (2002)
Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up- regulated in alternatively activated macrophages and secreted via lysosomal pathway. (PubMed id 16357325)^{1, 2, 9} Kzhyshkowska J.... Goerdt S. (2006)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)^{1, 2} Nagase T....Nomura N. (1996)
Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors. (PubMed id 15345724)^{1, 9} Kzhyshkowska J....Goerdt S. (2004)
CLEVER-1 mediates lymphocyte transmigration through vascular and lymphatic endothelium. (PubMed id 15297319)^{1, 9} Salmi M....Jalkanen S. (2004)
A novel GGA-binding site is required for intracellula r sorting mediated by stabilin-1. (PubMed id 19752197)^{1, 9} Zhang J....Kzhyshkowska J. (2009)
Rapid plasma membrane-endosomal trafficking of the lymph node sinus and high endothelial venule scavenger receptor/homing receptor stabilin-1 (FEEL-1/CLEVER-1). (PubMed id 15345716)^{1, 9} Prevo R....Jackson D.G. (2004)
Cross-talk between endocytic clearance and secretion in macrophages. (PubMed id 19457577)^{1, 9} Kzhyshkowska J. and Krusell L. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23166	HGNC: 18628	AceView: STAB1	Ensembl:ENSG00000010327	euGenes: HUgn23166
ECgene: STAB1	H-InvDB: STAB1

(According to HUGE)
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HUGE: KIAA0246

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for STAB1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for STAB1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for STAB1 gene:
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