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ST8SIA6 Gene

protein-coding   GIFtS: 45
GCID: GC10M017360

ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase...

(Previous names: sialyltransferase 8F (alpha-2, 8-sialyltransferase))
(Previous symbol: SIAT8F)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 61 2     ST8SIA-VI2
SIAT8F1 2 3     Alpha-2,8-Sialyltransferase 8F2
Sialyltransferase 8F (Alpha-2, 8-Sialyltransferase)1 2     Alpha-2,8-Sialyltransferase 8F Variant 22
Sialyltransferase St8Sia VI2 3     Alpha-2,8-Sialyltransferase 8F Variant 32
SIAT8-F2 3     Sialytransferase St8Sia VI2
ST8SiaVI2 3     EC 2.4.99.-3
ST8Sia VI1     Sialyltransferase 8F3
SIA8F2     

External Ids:    HGNC: 233171   Entrez Gene: 3385962   Ensembl: ENSG000001484887   OMIM: 6101395   UniProtKB: P616473   

Export aliases for ST8SIA6 gene to outside databases

Previous GC identifers: GC10M017403 GC10M017276


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ST8SIA6 Gene:
Sialic acid is a key determinate of oligosaccharide structures involved in cell-cell communication, cell-substrate
interaction, adhesion, and protein targeting. ST8SIA6 belongs to a family of sialyltransferases (EC 2.4.99.8)
that synthesize sialylglycoconjugates (Takashima et al., 2002 (PubMed 11980897)).(supplied by OMIM, Mar 2008)

GeneCards Summary for ST8SIA6 Gene:
ST8SIA6 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6) is a protein-coding gene. GO annotations related to this gene include sialyltransferase activity. An important paralog of this gene is ST8SIA5.

UniProtKB/Swiss-Prot: SIA8F_HUMAN, P61647
Function: Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is
the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ST8SIA6 gene promoter:
         RFX1   Pax-5   SREBP-1c   CUTL1   SREBP-1b   SREBP-1a   FOXO1a   NF-Y   FOXO1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidST8SIA6 promoter sequence
   Search Chromatin IP Primers for ST8SIA6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST8SIA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.33   Ensembl cytogenetic band:  10p12.33   HGNC cytogenetic band: 10p13

ST8SIA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST8SIA6 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M017360:  view genomic region     (about GC identifiers)

Start:
17,360,382 bp from pter      End:
17,496,329 bp from pter
Size:
135,948 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIA8F_HUMAN, P61647 (See protein sequence)
Recommended Name: Alpha-2,8-sialyltransferase 8F  
Size: 398 amino acids; 44836 Da
Secondary accessions: B0YJ97 B9EH72 Q5VZH4

Explore the universe of human proteins at neXtProt for ST8SIA6: NX_P61647

Explore proteomics data for ST8SIA6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn66, Asn93, Asn151, Asn196
  • Modification sites at PhosphoSitePlus

  • See ST8SIA6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004470.1  
    ENSEMBL proteins: 
     ENSP00000388343   ENSP00000366827  
    Reactome Protein details: P61647

    ST8SIA6 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ST8SIA6 

    ST8SIA6 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for ST8SIA6

    ST8SIA6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ST8SIA6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ST3G: Sialyltransferases

    2 InterPro protein domains:
     IPR001675 Glyco_trans_29
     IPR012163 Sialyl_trans

    Graphical View of Domain Structure for InterPro Entry P61647

    ProtoNet protein and cluster: P61647

    1 Blocks protein domain: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIA8F_HUMAN, P61647
    Similarity: Belongs to the glycosyltransferase 29 family


    Find genes that share domains with ST8SIA6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIA8F_HUMAN, P61647
    Function: Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is
    the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity)

         Enzyme Number (IUBMB): EC 2.4.99.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008373sialyltransferase activity ISS11980897
         
    Find genes that share ontologies with ST8SIA6           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ST8SIA6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ST8SIA6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ST8SIA6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ST8SIA6

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ST8SIA6 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidST8SIA6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ST8SIA6
    Predesigned siRNA for gene silencing in human, mouse, rat ST8SIA6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ST8SIA6

    Clone
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    OriGene clones in human, mouse for ST8SIA6 (see all 7)
    OriGene ORF clones in mouse, rat for ST8SIA6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ST8SIA6 (NM_001004470)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST8SIA6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST8SIA6

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIA8F_HUMAN, P61647: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular2
    endoplasmic reticulum1
    lysosome1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0030173integral component of Golgi membrane IEA--

    Find genes that share ontologies with ST8SIA6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ST8SIA6 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Metabolism of proteins0.30
    Post-translational protein modification0.43
    N-glycan antennae elongation in the medial/trans-Golgi0.00
    Transport to the Golgi and subsequent modification0.40
    N-Glycan antennae elongation0.00


    Find genes that share SuperPaths with ST8SIA6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for ST8SIA6
        Sialic acid metabolism
    N-Glycan antennae elongation


    UniProtKB/Swiss-Prot: SIA8F_HUMAN, P61647
    Pathway: Protein modification; protein glycosylation

        Pathway & Disease-focused RT2 Profiler PCR Array including ST8SIA6: 

              Glycosylation in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ST8SIA6

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ST8SIA6 (ENSP000003668274) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001574ganglioside biosynthetic process ISS11980897
    GO:0006486protein glycosylation ----
    GO:0006493protein O-linked glycosylation ISS11980897
    GO:0009100glycoprotein metabolic process ISS11980897
    GO:0009247glycolipid biosynthetic process ISS11980897

    Find genes that share ontologies with ST8SIA6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ST8SIA6 (SIA8F)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ST8SIA6 gene: 
    NM_001004470.1  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000440449 ENST00000377602(uc001ipd.3 uc010qce.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ST8SIA6 using miScript Target Protectors
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    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ST8SIA6
    Predesigned siRNA for gene silencing in human, mouse, rat ST8SIA6
    Clone
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    OriGene clones in human, mouse for ST8SIA6 (see all 7)
    OriGene ORF clones in mouse, rat for ST8SIA6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ST8SIA6 (NM_001004470)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST8SIA6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST8SIA6
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ST8SIA6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ST8SIA6
      QuantiTect SYBR Green Assays in human, mouse, rat ST8SIA6
      QuantiFast Probe-based Assays in human, mouse, rat ST8SIA6

    7 AceView cDNA sequences:

    AJ621583 BX951710 AI399872 BX283726 AV714822 BF678643 AV724160 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ST8SIA6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGGAATCC
    ST8SIA6 Expression
    About this image


    ST8SIA6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Bone (Muscoskeletal System)
             Zeugopod Growth Plate
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells II Spleen
     
     Brain (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
    ST8SIA6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ST8SIA6 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including ST8SIA6: 
              Glycosylation in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ST8SIA6
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    QuantiFast Probe-based Assays in human, mouse, rat ST8SIA6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST8SIA6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ST8SIA6 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St8sia61 , 5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more1, 5 82.33(n)1
    82.66(a)1
      2 (10.09 cM)5
    2412301  NM_145838.11  NP_665837.11 
     136510205 
    chicken
    (Gallus gallus)
    Aves ST8SIA61 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more 68.9(n)
    65.18(a)
      414335  NM_001001603.1  NP_001001603.1 
    lizard
    (Anolis carolinensis)
    Reptilia ST8SIA66
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltra...
    65(a)
    1 ↔ 1
    6(18217621-18265549)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia st8sia61 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more 64.13(n)
    61.27(a)
      100036736  NM_001097280.1  NP_001090749.1 
    zebrafish
    (Danio rerio)
    Actinopterygii st8sia61 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more 53.99(n)
    45.42(a)
      553212  XM_678306.6  XP_683398.2 


    ENSEMBL Gene Tree for ST8SIA6 (if available)
    TreeFam Gene Tree for ST8SIA6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ST8SIA6 gene
    ST8SIA52  ST8SIA12  ST8SIA32  ST8SIA22  ST8SIA42  
    7 SIMAP similar genes for ST8SIA6 using alignment to 2 protein entries:     SIA8F_HUMAN (see all proteins):
    SIA8F    ST8Sia VI    ST8SIA1    ST8SIA5    ST8SIA3    ST8SIA2
    ST8SIA4

    Find genes that share paralogs with ST8SIA6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ST8SIA6 (see all 2687)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1511139431,2
    C--17362190(+) TGAGAA/GAGAAA 1 -- ds50010--------
    rs1834767731,2
    C--17362308(+) GCTACA/TATTAA 1 -- ds50010--------
    rs70911141,2
    C,F,A,H--17362384(+) AAGAAC/TTTTTT 1 -- ds500118Minor allele frequency- T:0.40NA NS EA WA CSA 953
    rs112545221,2
    C,F--17362391(+) TTTTGC/TTTAAG 1 -- ds50012Minor allele frequency- T:0.17WA 120
    rs1114220041,2
    C--17362481(+) ATCCAA/GTGGAT 1 -- ds50010--------
    rs112545231,2
    C,F,A,H--17362487(+) TGGATA/GCTGGT 1 -- ds500118Minor allele frequency- G:0.27NS EA NA WA CSA 980
    rs761166341,2
    C,F--17362513(+) TTTAGA/GAGAGA 1 -- ds50011Minor allele frequency- G:0.09WA 118
    rs1884182741,2
    --17362529(+) AAGAAA/GGCATG 1 -- ds50010--------
    rs1150797871,2
    C,F--17362545(+) ATTATC/TGGTCT 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1121270991,2
    C--17362546(+) TTATCC/GGTCTG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ST8SIA6 (17360382 - 17496329 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ST8SIA6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2733650CNV Deletion23290073
    esv2027380CNV Deletion18987734
    esv2658114CNV Deletion23128226
    esv2733639CNV Deletion23290073
    nsv5966CNV Insertion18451855
    nsv24310CNV Loss16902084
    nsv5954CNV Loss18451855
    nsv894908CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ST8SIA6
    DNA2.0 Custom Variant and Variant Library Synthesis for ST8SIA6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610139    OMIM disorders: --


    Find genes that share disorders with ST8SIA6           About GenesLikeMe

    Genetic Association Database (GAD): ST8SIA6

    Export disorders for ST8SIA6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ST8SIA6 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with ST8SIA6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. (PubMed id 19176441)1, 4 Yang J.J....Relling M.V. (JAMA 2009)
    2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    3. Molecular cloning and expression of a sixth type of alpha 2,8-sialyltransferase (ST8Sia VI) that sialylates O-glycans. (PubMed id 11980897)1, 3 Takashima S....Tsujimoto M. (J. Biol. Chem. 2002)
    4. Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression. (PubMed id 16857734)1, 9 Avril T....Crocker P.R. (J. Leukoc. Biol. 2006)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (BMC Med. Genet. 2007)
    7. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)4 Seshadri S....Wolf P.A. (BMC Med. Genet. 2007)
    8. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    9. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. (PubMed id 15843597)1 Harduin-Lepers A.... Oriol R. (Glycobiology 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 338596 HGNC: 23317 AceView: SIAT8F Ensembl:ENSG00000148488 euGenes: HUgn338596
    ECgene: ST8SIA6 H-InvDB: ST8SIA6

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ST8SIA6 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST8SIA6
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_641

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ST8SIA6 gene:
    Search GeneIP for patents involving ST8SIA6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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