Aliases for ST8SIA6 Gene
External Ids for ST8SIA6 Gene
Previous HGNC Symbols for ST8SIA6 Gene
Previous GeneCards Identifiers for ST8SIA6 Gene
Sialic acid is a key determinate of oligosaccharide structures involved in cell-cell communication, cell-substrate interaction, adhesion, and protein targeting. ST8SIA6 belongs to a family of sialyltransferases (EC 22.214.171.124) that synthesize sialylglycoconjugates (Takashima et al., 2002 [PubMed 11980897]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ST8SIA6 Gene
ST8SIA6 (ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 6) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include sialyltransferase activity. An important paralog of this gene is ST8SIA1.
UniProtKB/Swiss-Prot for ST8SIA6 Gene
Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity).