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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ST8SIA6 Gene

protein-coding   GIFtS: 48
GCID: GC10M017360

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase...

(Previous names: sialyltransferase 8F (alpha-2, 8-sialyltransferase) )
(Previous symbol: SIAT8F)
 Explore 3 diseases affiliated with
ST8SIA6 via our new
 Human Malady Compendium 
Biological research products
for ST8SIA6
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 61 2     ST8SIA-VI2
SIAT8F1 2 3     Alpha-2,8-Sialyltransferase 8F2
Sialyltransferase 8F (Alpha-2, 8-Sialyltransferase)1 2     Alpha-2,8-Sialyltransferase 8F Variant 22
Sialyltransferase St8Sia VI2 3     Alpha-2,8-Sialyltransferase 8F Variant 32
SIAT8-F2 3     Sialytransferase St8Sia VI2
ST8SiaVI2 3     EC 2.4.99.-3
SIA8F2     Sialyltransferase 8F3

External Ids:    HGNC: 233171   Entrez Gene: 3385962   Ensembl: ENSG000001484887   OMIM: 6101395   UniProtKB: P616473   

Export aliases for ST8SIA6 gene to outside databases

Previous GC identifers: GC10M017403 GC10M017276


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ST8SIA6:
Sialic acid is a key determinate of oligosaccharide structures involved in cell-cell communication, cell-substrate
interaction, adhesion, and protein targeting. ST8SIA6 belongs to a family of sialyltransferases (EC 2.4.99.8) that
synthesize sialylglycoconjugates (Takashima et al., 2002 (PubMed 11980897)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: SIA8F_HUMAN, P61647
Function: Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the
NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ST8SIA6 gene promoter:
         RFX1   Pax-5   SREBP-1c   CUTL1   SREBP-1b   SREBP-1a   FOXO1a   NF-Y   FOXO1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidST8SIA6 promoter sequence
   Search SABiosciences Chromatin IP Primers for ST8SIA6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST8SIA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.33   Ensembl cytogenetic band:  10p12.33   HGNC cytogenetic band: 10p13

ST8SIA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST8SIA6 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M017360:  view genomic region     (about GC identifiers)

Start:
17,360,382 bp from pter      End:
17,496,329 bp from pter
Size:
135,948 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SIA8F_HUMAN, P61647 (See protein sequence)
Recommended Name: Alpha-2,8-sialyltransferase 8F  
Size: 398 amino acids; 44836 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
Secondary accessions: B0YJ97 B9EH72 Q5VZH4

Explore the universe of human proteins at neXtProt for ST8SIA6: NX_P61647

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P61647

  • ST8SIA6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001004470.1  
    ENSEMBL proteins: 
     ENSP00000388343   ENSP00000366827  
    Reactome Protein details: P61647
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ST8SIA6

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0030173integral to Golgi membrane IEA--


    ST8SIA6 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ST8SIA6


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ST8SIA6 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001675 Glyco_trans_29
     IPR012163 Sialyl_trans

    Graphical View of Domain Structure for InterPro Entry P61647

    ProtoNet protein and cluster: P61647

    1 Blocks protein family: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIA8F_HUMAN, P61647
    Similarity: Belongs to the glycosyltransferase 29 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SIA8F_HUMAN, P61647
    Function: Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the
    NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity)

    Enzyme Number (IUBMB): EC 2.4.99.-1

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ST8SIA6 (see all 7)
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    OriGene siRNA: ST8SIA6
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST8SIA6

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008373sialyltransferase activity ISS11980897


    ST8SIA6 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1N-glycan antennae elongation in the medial/trans-Golgi
    N-glycan antennae elongation in the medial/trans-Golgi1.00
    Transport to the Golgi and subsequent modification0.56
    N-Glycan antennae elongation0.75
    2Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation1.00
    Metabolism of proteins0.15
    Post-translational protein modification0.44

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for ST8SIA6 (see all 6)
        N-glycan antennae elongation in the medial/trans-Golgi
    Transport to the Golgi and subsequent modification
    Asparagine N-linked glycosylation
    N-Glycan antennae elongation
    Metabolism of proteins


    UniProtKB/Swiss-Prot: SIA8F_HUMAN, P61647
    Pathway: Protein modification; protein glycosylation


    ST8SIA6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ST8SIA6

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ST8SIA6 (ENSP000003668274) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001574ganglioside biosynthetic process ISS11980897
    GO:0006493protein O-linked glycosylation ISS11980897
    GO:0009100glycoprotein metabolic process ISS11980897
    GO:0009247glycolipid biosynthetic process ISS11980897
    GO:0009311oligosaccharide metabolic process ISS11980897


    ST8SIA6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ST8SIA6
    Search CenterWatch for drugs/clinical trials and news about ST8SIA6 / SIA8F 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ST8SIA6 gene: 
    NM_001004470.1  

    Unigene Cluster for ST8SIA6:

    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
    Hs.677766  [show with all ESTs]
    Unigene Representative Sequence: BC137102
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000440449 ENST00000377602(uc001ipd.3 uc010qce.2) ENST00000479513


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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ST8SIA6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST8SIA6

    Additional cDNA sequence: 

    AB062101.1 AJ621583.1 BC137102.1 BC137103.1 BC144472.1 

    2 DOTS entries:

    DT.91897044  DT.100665034 

    7 AceView cDNA sequences:

    AJ621583 AI399872 BX951710 AV714822 BX283726 BF678643 AV724160 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ST8SIA6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAGGAATCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    ST8SIA6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleCumulus CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ST8SIA6 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.677766
        SABiosciences Expression via Pathway-Focused PCR Array including ST8SIA6: 
              Glycosylation in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST8SIA6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ST8SIA6 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ST8SIA61 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more 68.9(n)
    65.18(a)
      414335  NM_001001603.1  NP_001001603.1 
    lizard
    (Anolis carolinensis)
    Reptilia A5I882_ANOCA6
    Alpha 2,8-sialyltransferase ST8Sia VI Fragment (EC...
    70(a)
    1 ↔ 1
    6(18252745-18265543)
    zebrafish
    (Danio rerio)
    Actinopterygii st8sia61 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more 54.11(n)
    45.42(a)
      553212  XM_678306.5  XP_683398.2 


    ENSEMBL Gene Tree for ST8SIA6 (if available)
    TreeFam Gene Tree for ST8SIA6 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ST8SIA6 gene
    ST8SIA52  ST8SIA12  ST8SIA32  ST8SIA22  ST8SIA42  
    7 SIMAP similar genes for ST8SIA6 using alignment to 2 protein entries:     SIA8F_HUMAN (see all proteins):
    SIA8F    ST8Sia VI    ST8SIA1    ST8SIA5    ST8SIA3    ST8SIA2
    ST8SIA4

    ST8SIA6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2765 NCBI SNPs in ST8SIA6 are shown (see all 2765    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1511139431,2
    --17362190(+) TGAGAA/GAGAAA 1 -- ds50010--------
    rs1834767731,2
    --17362308(+) GCTACA/TATTAA 1 -- ds50010--------
    rs70911141,2
    C,F,A,H,--17362384(+) AAGAAC/TTTTTT 1 -- ds500118Minor allele frequency- T:0.40NA NS EA WA CSA 953
    rs112545221,2
    C,--17362391(+) TTTTGC/TTTAAG 1 -- ds50012Minor allele frequency- T:0.17WA 120
    rs1114220041,2
    C,--17362481(+) ATCCAA/GTGGAT 1 -- ds50010--------
    rs112545231,2
    C,F,A,H,--17362487(+) TGGATA/GCTGGT 1 -- ds500118Minor allele frequency- G:0.27NS EA NA WA CSA 980
    rs761166341,2
    F,--17362513(+) TTTAGA/GAGAGA 1 -- ds50011Minor allele frequency- G:0.09WA 118
    rs1884182741,2
    --17362529(+) AAGAAA/GGCATG 1 -- ds50010--------
    rs1150797871,2
    F,--17362545(+) ATTATC/TGGTCT 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1121270991,2
    C,--17362546(+) TTATCC/GGTCTG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ST8SIA6 (17360382 - 17496329 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ST8SIA6
         1 Indel: 11457

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ST8SIA6 for disorders           About GeneDecksing

    OMIM gene information: 610139    OMIM disorders: --

    3 diseases for ST8SIA6:    About MalaCards
    acute lymphoblastic leukemia    lymphoblastic leukemia    leukemia


    Export disorders for ST8SIA6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ST8SIA6 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ST8SIA6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    2. Molecular cloning and expression of a sixth type of alpha 2,8-sialyltransferase (ST8Sia VI) that sialylates O-glycans. (PubMed id 11980897)1, 3 Takashima S....Tsujimoto M. (2002)
    3. Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression. (PubMed id 16857734)1, 9 Avril T....Crocker P.R. (2006)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. (PubMed id 19176441)1 Yang J.J....Relling M.V. (2009)
    6. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. (PubMed id 15843597)1 Harduin-Lepers A.... Oriol R. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 338596 HGNC: 23317 AceView: SIAT8F Ensembl:ENSG00000148488 euGenes: HUgn338596
    ECgene: ST8SIA6 H-InvDB: ST8SIA6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ST8SIA6 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST8SIA6
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_641

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ST8SIA6 gene:
    Search GeneIP for patents involving ST8SIA6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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