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Aliases for ST8SIA6 Gene

Aliases for ST8SIA6 Gene

  • ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 6 2 3 5
  • ST8 Alpha-N-Acetylneuraminate Alpha-2,8-Sialyltransferase 6 2 3
  • Sialyltransferase 8F (Alpha-2, 8-Sialyltransferase) 2 3
  • Sialyltransferase St8Sia VI 3 4
  • ST8SiaVI 3 4
  • SIAT8-F 3 4
  • SIAT8F 3 4
  • Alpha-2,8-Sialyltransferase 8F Variant 1 3
  • Alpha-2,8-Sialyltransferase 8F Variant 2 3
  • Alpha-2,8-Sialyltransferase 8F Variant 3 3
  • Alpha-2,8-Sialyltransferase 8F 3
  • Sialytransferase St8Sia VI 3
  • Sialyltransferase 8F 4
  • EC 2.4.99.- 4
  • ST8Sia VI 2
  • ST8SIA-VI 3
  • SIA8F 3

External Ids for ST8SIA6 Gene

Previous HGNC Symbols for ST8SIA6 Gene

  • SIAT8F

Previous GeneCards Identifiers for ST8SIA6 Gene

  • GC10M017403
  • GC10M017276

Summaries for ST8SIA6 Gene

Entrez Gene Summary for ST8SIA6 Gene

  • Sialic acid is a key determinate of oligosaccharide structures involved in cell-cell communication, cell-substrate interaction, adhesion, and protein targeting. ST8SIA6 belongs to a family of sialyltransferases (EC 2.4.99.8) that synthesize sialylglycoconjugates (Takashima et al., 2002 [PubMed 11980897]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ST8SIA6 Gene

ST8SIA6 (ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 6) is a Protein Coding gene. Among its related pathways are Synthesis of substrates in N-glycan biosythesis and Transport to the Golgi and subsequent modification. GO annotations related to this gene include sialyltransferase activity. An important paralog of this gene is ST8SIA5.

UniProtKB/Swiss-Prot for ST8SIA6 Gene

  • Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST8SIA6 Gene

Genomics for ST8SIA6 Gene

Regulatory Elements for ST8SIA6 Gene

Enhancers for ST8SIA6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ST8SIA6 on UCSC Golden Path with GeneCards custom track

Promoters for ST8SIA6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ST8SIA6 Gene

Chromosome:
10
Start:
17,315,414 bp from pter
End:
17,455,510 bp from pter
Size:
140,097 bases
Orientation:
Minus strand

Genomic View for ST8SIA6 Gene

Genes around ST8SIA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST8SIA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST8SIA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST8SIA6 Gene

Proteins for ST8SIA6 Gene

  • Protein details for ST8SIA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61647-SIA8F_HUMAN
    Recommended name:
    Alpha-2,8-sialyltransferase 8F
    Protein Accession:
    P61647
    Secondary Accessions:
    • B0YJ97
    • B9EH72
    • Q5VZH4

    Protein attributes for ST8SIA6 Gene

    Size:
    398 amino acids
    Molecular mass:
    44836 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST8SIA6 Gene

Post-translational modifications for ST8SIA6 Gene

  • Glycosylation at Asn 66, Asn 93, Asn 151, and Asn 196
  • Modification sites at PhosphoSitePlus

Other Protein References for ST8SIA6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ST8SIA6 Gene

Domains & Families for ST8SIA6 Gene

Gene Families for ST8SIA6 Gene

Protein Domains for ST8SIA6 Gene

Suggested Antigen Peptide Sequences for ST8SIA6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61647

UniProtKB/Swiss-Prot:

SIA8F_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST8SIA6: view

Function for ST8SIA6 Gene

Molecular function for ST8SIA6 Gene

UniProtKB/Swiss-Prot Function:
Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity).

Enzyme Numbers (IUBMB) for ST8SIA6 Gene

Gene Ontology (GO) - Molecular Function for ST8SIA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity TAS --
GO:0008373 sialyltransferase activity IEA,ISS 11980897
genes like me logo Genes that share ontologies with ST8SIA6: view
genes like me logo Genes that share phenotypes with ST8SIA6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ST8SIA6 Gene

Localization for ST8SIA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST8SIA6 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST8SIA6 Gene COMPARTMENTS Subcellular localization image for ST8SIA6 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ST8SIA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0030173 integral component of Golgi membrane IEA --
genes like me logo Genes that share ontologies with ST8SIA6: view

Pathways & Interactions for ST8SIA6 Gene

genes like me logo Genes that share pathways with ST8SIA6: view

UniProtKB/Swiss-Prot P61647-SIA8F_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for ST8SIA6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366827%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000366827 P61647-SIA8F_HUMAN for ST8SIA6 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ST8SIA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001574 ganglioside biosynthetic process IEA,ISS 11980897
GO:0006493 protein O-linked glycosylation IEA,ISS 11980897
GO:0009100 glycoprotein metabolic process IEA,ISS 11980897
GO:0009247 glycolipid biosynthetic process IEA,ISS 11980897
GO:0009311 oligosaccharide metabolic process IEA,ISS 11980897
genes like me logo Genes that share ontologies with ST8SIA6: view

No data available for SIGNOR curated interactions for ST8SIA6 Gene

Drugs & Compounds for ST8SIA6 Gene

No Compound Related Data Available

Transcripts for ST8SIA6 Gene

mRNA/cDNA for ST8SIA6 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ST8SIA6 Gene

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST8SIA6 Gene

No ASD Table

Relevant External Links for ST8SIA6 Gene

GeneLoc Exon Structure for
ST8SIA6
ECgene alternative splicing isoforms for
ST8SIA6

Expression for ST8SIA6 Gene

mRNA expression in normal human tissues for ST8SIA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ST8SIA6 Gene:

ST8SIA6

SOURCE GeneReport for Unigene cluster for ST8SIA6 Gene:

Hs.677766
genes like me logo Genes that share expression patterns with ST8SIA6: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ST8SIA6 Gene

Orthologs for ST8SIA6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST8SIA6 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ST8SIA6 34
  • 85.34 (n)
  • 79.65 (a)
ST8SIA6 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St8sia6 34
  • 82.33 (n)
  • 82.66 (a)
St8sia6 16
St8sia6 35
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ST8SIA6 34
  • 99.41 (n)
  • 99.5 (a)
ST8SIA6 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia St8sia6 34
  • 81.32 (n)
  • 81.41 (a)
cow
(Bos Taurus)
Mammalia ST8SIA6 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ST8SIA6 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves ST8SIA6 34
  • 68.9 (n)
  • 65.18 (a)
ST8SIA6 35
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST8SIA6 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st8sia6 34
  • 64.13 (n)
  • 61.27 (a)
zebrafish
(Danio rerio)
Actinopterygii st8sia6 34
  • 53.99 (n)
  • 45.42 (a)
st8sia6 35
  • 37 (a)
OneToOne
Species where no ortholog for ST8SIA6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST8SIA6 Gene

ENSEMBL:
Gene Tree for ST8SIA6 (if available)
TreeFam:
Gene Tree for ST8SIA6 (if available)

Paralogs for ST8SIA6 Gene

Paralogs for ST8SIA6 Gene

(7) SIMAP similar genes for ST8SIA6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ST8SIA6: view

Variants for ST8SIA6 Gene

Sequence variations from dbSNP and Humsavar for ST8SIA6 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs187213 -- 17,340,466(-) aattc(C/T)gattg intron-variant
rs359309 -- 17,339,833(-) TCAta(C/T)gtgac intron-variant
rs359310 -- 17,339,573(-) CTATG(C/T)ATGTT intron-variant
rs359311 -- 17,338,805(-) GGAAA(C/T)TGCTG intron-variant, upstream-variant-2KB
rs359312 -- 17,346,144(-) tatgt(A/G)acttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST8SIA6 Gene

Variant ID Type Subtype PubMed ID
esv2027380 CNV deletion 18987734
esv2658114 CNV deletion 23128226
esv2733639 CNV deletion 23290073
esv2733650 CNV deletion 23290073
esv3407759 CNV insertion 20981092
esv3576094 CNV gain 25503493
esv3578664 CNV loss 25503493
esv3622484 CNV gain 21293372
esv3622485 CNV loss 21293372
esv3891766 CNV loss 25118596
nsv1039697 CNV loss 25217958
nsv1046522 CNV loss 25217958
nsv1068286 CNV deletion 25765185
nsv1069028 CNV deletion 25765185
nsv1116633 CNV tandem duplication 24896259
nsv1127090 CNV deletion 24896259
nsv24310 CNV deletion 16902084
nsv474853 CNV novel sequence insertion 20440878
nsv5954 CNV deletion 18451855
nsv5966 CNV insertion 18451855

Variation tolerance for ST8SIA6 Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.29; 62.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ST8SIA6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST8SIA6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST8SIA6 Gene

Disorders for ST8SIA6 Gene

Relevant External Links for ST8SIA6

Genetic Association Database (GAD)
ST8SIA6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ST8SIA6

No disorders were found for ST8SIA6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST8SIA6 Gene

Publications for ST8SIA6 Gene

  1. Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. (PMID: 19176441) Yang J.J. … Relling M.V. (JAMA 2009) 3 46 65
  2. Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression. (PMID: 16857734) Avril T. … Crocker P.R. (J. Leukoc. Biol. 2006) 3 22 65
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 65
  4. Molecular cloning and expression of a sixth type of alpha 2,8-sialyltransferase (ST8Sia VI) that sialylates O-glycans. (PMID: 11980897) Takashima S. … Tsujimoto M. (J. Biol. Chem. 2002) 2 3 65
  5. I+-2,8-sialyltransferase is involved in the development of multidrug resistance via PI3K/Akt pathway in human chronic myeloid leukemia. (PMID: 25855199) Zhang X. … Jia L. (IUBMB Life 2015) 3 65

Products for ST8SIA6 Gene

Sources for ST8SIA6 Gene

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