Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ST8SIA5 Gene

protein-coding   GIFtS: 53
GCID: GC18M044259

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase...

(Previous names: sialyltransferase 8E (alpha-2, 8-polysialytransferase)...)
(Previous symbol: SIAT8E)
 Explore 2 diseases affiliated with
ST8SIA5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ST8SIA5    

Aliases
for ST8SIA5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 51 2     ST8SiaV2 3
SIAT8E1 2 3 5     Alpha-2,8-Sialyltransferase 8E2
Sialyltransferase 8E (Alpha-2, 8-Polysialytransferase)1 2     Sialytransferase St8Sia V2
Sialyltransferase St8Sia V2 3     EC 2.4.99.-3
SIAT8-E2 3     Sialyltransferase 8E3

External Ids:    HGNC: 178271   Entrez Gene: 299062   Ensembl: ENSG000001016387   OMIM: 6071625   UniProtKB: O154663   

Export aliases for ST8SIA5 gene to outside databases

Previous GC identifers: GC18M042514 GC18M041116


Summaries
for ST8SIA5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ST8SIA5:
The protein encoded by this gene is a type II membrane protein that may be present in the Golgi apparatus. The encoded
protein, which is a member of glycosyltransferase family 29, may be involved in the synthesis of gangliosides GD1c,
GT1a, GQ1b, and GT3 from GD1a, GT1b, GM1b, and GD3, respectively. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SIA8E_HUMAN, O15466
Function: May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3
respectively




Genomic Views
for ST8SIA5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_010966.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ST8SIA5 gene promoter:
         COUP-TF1   FOXF2   Bach2   MyoD   COUP   HNF-4alpha2   HNF-4alpha1   SREBP-1a   COUP-TF   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ST8SIA5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ST8SIA5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST8SIA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.1   Ensembl cytogenetic band:  18q21.1   HGNC cytogenetic band: 18q12.3

ST8SIA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST8SIA5 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M044259:  view genomic region     (about GC identifiers)

Start:
 44,259,081 bp from pter      End:
 44,339,220 bp from pter
Size:
 80,140 bases      Orientation:
 minus strand

Proteins
for ST8SIA5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SIA8E_HUMAN, O15466 (See protein sequence)
Recommended Name: Alpha-2,8-sialyltransferase 8E  
Size: 376 amino acids; 43895 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
Secondary accessions: Q6IAW7

Explore the universe of human proteins at neXtProt for ST8SIA5: NX_O15466

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15466

    • ST8SIA5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_037437.2  
    ENSEMBL proteins: 
     ENSP00000321343   ENSP00000445492   ENSP00000443683   ENSP00000468112   ENSP00000466787  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for ST8SIA5 
    GenScript Custom Purified and Recombinant Proteins Services for ST8SIA5
    Novus Biologicals ST8SIA5 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ST8SIA5

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030173integral to Golgi membrane IEA--


    ST8SIA5 for ontologies           About GeneDecksing



    ST8SIA5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ST8SIA5 
    GenScript Custom Superior Antibodies Services for ST8SIA5
    Search for Antibodies for ST8SIA5 at Abcam  
    Uscn Antibodies for ST8SIA5
    ThermoFisher Antibody for ST8SIA5

    Assay Products for ST8SIA5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ST8SIA5
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ST8SIA5

    Protein Domains /
    Families
    for ST8SIA5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ST8SIA5 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001675 Glyco_trans_29
     IPR012163 Sialyl_trans

    Graphical View of Domain Structure for InterPro Entry O15466

    ProtoNet protein and cluster: O15466

    1 Blocks protein family: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIA8E_HUMAN, O15466
    Similarity: Belongs to the glycosyltransferase 29 family


    Function
    for ST8SIA5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SIA8E_HUMAN, O15466
    Function: May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3
    respectively

    Enzyme Number (IUBMB): EC 2.4.99.-1

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST8SIA5
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate ST8SIA5 (see all 20):
    hsa-miR-301a hsa-miR-340 hsa-miR-218 hsa-miR-3125 hsa-miR-3916 hsa-miR-3605-5p hsa-miR-130b hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmid: ST8SIA5 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ST8SIA5 (see all 7)
    OriGene shRNA RFP: ST8SIA5
    OriGene siRNA: ST8SIA5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST8SIA5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ST8SIA5

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ST8SIA5 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ST8SIA5
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ST8SIA5 (NM_013305)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST8SIA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST8SIA5 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ST8SIA5
    Search LifeMap BioReagents cell lines for ST8SIA5

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST8SIA5

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003828alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IEA--
    GO:0008373sialyltransferase activity TAS9199191


    ST8SIA5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ST8SIA5:
     Increased number of cells in m 


    Pathways & Interactions
    for ST8SIA5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ganglio Sphingolipid Metabolism
    		Ganglio Sphingolipid Metabolism1.00
    		Glycosphingolipid biosynthesis - ganglio series0.53
    2Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for ST8SIA5 
        Ganglio Sphingolipid Metabolism


    2         Kegg Pathways  (Kegg details for ST8SIA5):
        Glycosphingolipid biosynthesis - ganglio series
    Metabolic pathways

    UniProtKB/Swiss-Prot: SIA8E_HUMAN, O15466
    Pathway: Protein modification; protein glycosylation


    ST8SIA5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ST8SIA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for ST8SIA5 (ENSP000003213434) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    B4GALNT1ENSP000003415624STRING: ENSP00000341562
    ST3GAL1ENSP000003184454STRING: ENSP00000318445
    ST3GAL2ENSP000003454774STRING: ENSP00000345477
    ST6GALNAC3ENSP000003292144STRING: ENSP00000329214
    ST6GALNAC5ENSP000004175834STRING: ENSP00000417583
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS9199191
    GO:0006486protein glycosylation IEA--
    GO:0006688glycosphingolipid biosynthetic process TAS9199191


    ST8SIA5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ST8SIA5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ST8SIA5
    Search CenterWatch for drugs/clinical trials and news about ST8SIA5 / SIA8E 

    Transcripts
    for ST8SIA5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ST8SIA5 gene: 
    NM_013305.4  

    Unigene Cluster for ST8SIA5:

    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
    Hs.465025  [show with all ESTs]
    Unigene Representative Sequence: NM_013305
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315087(uc002lci.1 uc002lcj.1 uc010xcy.1 uc010xcz.1 uc010dno.1)
    ENST00000590497 ENST00000538168 ENST00000536490 ENST00000587428 ENST00000589088
    ENST00000591375 ENST00000588155 ENST00000590488

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST8SIA5
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate ST8SIA5 (see all 20):
    hsa-miR-301a hsa-miR-340 hsa-miR-218 hsa-miR-3125 hsa-miR-3916 hsa-miR-3605-5p hsa-miR-130b hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmid: ST8SIA5 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ST8SIA5 (see all 7)
    OriGene shRNA RFP: ST8SIA5
    OriGene siRNA: ST8SIA5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST8SIA5
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ST8SIA5 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ST8SIA5
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ST8SIA5 (NM_013305)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST8SIA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST8SIA5 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ST8SIA5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ST8SIA5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ST8SIA5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST8SIA5

    Additional cDNA sequence: 

    AK056270.1 AK094273.1 AK130126.1 AK293608.1 AK298881.1 AK310764.1 BC108910.1 BC108911.1 
    CR457037.1 U91641.1 

    3 DOTS entries:

    DT.207251  DT.121084713  DT.97768771 

    24/29 AceView cDNA sequences (see all 29):

    AK130126 NM_013305 AW134945 AK094273 BM679941 U55966 BE798786 AW206911 
    AK056270 AW251085 U91641 AI692935 AW250347 BF968902 AU130750 BM723736 
    CR457037 AW157019 AW162481 AI681140 BF438207 AI689795 AW087114 BE041668 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ST8SIA5    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:                                                        -                 -               
    SP2:                    -     -     -                                         -               
    SP3:        -     -     -     -     -                                                         
    SP4:                    -     -                                                               
    SP5:                                                                                          


    ECgene alternative splicing isoforms for ST8SIA5

    Expression
    for ST8SIA5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ST8SIA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGGTCTTGGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ST8SIA5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimary FollicleGranulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ST8SIA5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ST8SIA5

    SOURCE GeneReport for Unigene cluster: Hs.465025

    UniProtKB/Swiss-Prot: SIA8E_HUMAN, O15466
    Tissue specificity: Expressed in fetal and adult brain, adult heart and skeletal muscle

        SABiosciences Custom PCR Arrays for ST8SIA5
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ST8SIA5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ST8SIA5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ST8SIA5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST8SIA5
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST8SIA5

    Orthologs
    for ST8SIA5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ST8SIA5 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ST8SIA51 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more 83.16(n)
    91.76(a)    		   414797  NM_001001747.1  NP_001001747.1 
    lizard
    (Anolis carolinensis)    		 Reptilia A5I881_ANOCA6
    		 Alpha 2,8-sialyltransferase ST8Sia V Fragment (EC ...
    		 85(a)
    		 1 ↔ 1
    		 1(34522202-34539814)
    zebrafish
    (Danio rerio)    		 Actinopterygii st8sia51 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more 71.85(n)
    73.19(a)    		   553754  NM_001204154.1  NP_001191083.1 


    ENSEMBL Gene Tree for ST8SIA5 (if available)
    TreeFam Gene Tree for ST8SIA5 (if available) 

    Paralogs
    for ST8SIA5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ST8SIA5 gene
    ST8SIA12  ST8SIA62  ST8SIA32  ST8SIA22  ST8SIA42  
    7 SIMAP similar genes for ST8SIA5 using alignment to 5 protein entries:     SIA8E_HUMAN (see all proteins):
    SIA8F    ST8SIA6    ST8SIA1    ST8Sia VI    ST8SIA4    ST8SIA2
    ST3GAL1

    ST8SIA5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ST8SIA5
    PGOHUM00000258704


    Genomic Variants
    for ST8SIA5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1387 NCBI SNPs in ST8SIA5 are shown (see all 1387)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1468610801,2
    		--44258583(+) AGAATA/GGGCTT 1 -- ds50010--------
    rs1154610431,2
    		C,F,--44258617(+) AGAAAA/GGAGGA 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1396788541,2
    		--44258653(+) GGCAGA/GGAGAA 1 -- ds50010--------
    rs782723941,2
    		C,--44258900(+) CCAGGC/GCCTGG 1 -- ds50012Minor allele frequency- G:0.02NA 122
    rs577142741,2
    		C,--44258926(+) GTCCCG/ACCTTC 1 -- ds50014Minor allele frequency- A:0.11NA WA EA 360
    rs1510558021,2
    		--44259031(+) AGCCTA/GTGGTT 1 -- ds50010--------
    rs1819599871,2
    		--44259112(+) TAACTA/CCTGGT 1 -- ut310--------
    rs1861887081,2
    		--44259279(+) CAAGAC/TCGCAT 1 -- ut310--------
    rs1409439101,2
    		--44259284(+) CCGCAC/TGTGTG 1 -- ut310--------
    rs1179285471,2
    		--44259524(+) TTCGAT/CATAAA 1 -- ut311Minor allele frequency- C:0.01NA 120

    HapMap Linkage Disequilibrium report for ST8SIA5 (44259081 - 44339220 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for ST8SIA5
         1 CNV: 67350
         4 Indels: 77870 88826 88825 77871

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ST8SIA5
    DNA2.0 Custom Variant and Variant Library Synthesis for ST8SIA5

    Disorders / Diseases
    for ST8SIA5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ST8SIA5 for disorders           About GeneDecksing

    OMIM gene information: 607162    OMIM disorders: --

    2 diseases for ST8SIA5:    About MalaCards
    bipolar disorder    alzheimer's disease


    Export disorders for ST8SIA5 gene to outside databases

    Publications
    for ST8SIA5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ST8SIA5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ST8SIA5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of human alpha2,8-sialyltransferase (hST8Sia V). (PubMed id 9199191)1, 2, 3 Kim Y.-J.... Lee Y.-C. (1997)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Ganglioside metabolism in a transgenic mouse model of Alzheimer's disease: expression of Chol-1I+ antigens in the brain. (PubMed id 20930939)1 Ariga T....Yu R.K. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Isolation of chromosome 18-specific brain transcripts as positional candidates for bipolar disorder. (PubMed id 9129712)1 Yoshikawa T....Detera-Wadleigh S.D. (1997)
    7. Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression. (PubMed id 16857734)9 Avril T....Crocker P.R. (2006)

    External Searches for ST8SIA5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ST8SIA5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29906 HGNC: 17827 AceView: SIAT8E Ensembl:ENSG00000101638 euGenes: HUgn29906
    ECgene: ST8SIA5 Kegg: 29906 H-InvDB: ST8SIA5

    Other Databases showing ST8SIA5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ST8SIA5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ST8SIA5 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST8SIA5
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_640

    Intellectual Property
    for ST8SIA5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ST8SIA5 gene:
    Search GeneIP for patents involving ST8SIA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ST8SIA5 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for ST8SIA5  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ST8SIA5   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ST8SIA5  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ST8SIA5   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ST8SIA5   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ST8SIA5  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ST8SIA5   OriGene Custom Protein Services for ST8SIA5  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ST8SIA5
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ST8SIA5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST8SIA5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST8SIA5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST8SIA5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ST8SIA5
     GenScript Custom Purified and Recombinant Proteins Services for ST8SIA5 GenScript cDNA clones with any tag delivered in your preferred vector for ST8SIA5
     GenScript Custom Assay Services for ST8SIA5 GenScript Custom Superior Antibodies Services for ST8SIA5
     GenScript Custom overexpressing Cell Line Services for ST8SIA5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ST8SIA5 promoter
     Search Chromatin IP Primers for ST8SIA5
     RT2 qPCR Primer Assay in human, mouse, rat ST8SIA5
     Search GNC Networks for ST8SIA5
     SABiosciences Custom PCR Arrays for ST8SIA5
     Search Tocris compounds for ST8SIA5
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ST8SIA5 proteins
     Search for Antibodies for ST8SIA5 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ST8SIA5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ST8SIA5 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ST8SIA5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST8SIA5
     SwitchGear 3'UTR luciferase reporter plasmids for ST8SIA5
     SwitchGear Promoter luciferase reporter plasmids for ST8SIA5
     ThermoFisher Antibody for ST8SIA5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST8SIA5
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ST8SIA5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4