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ST8SIA5 Gene

protein-coding   GIFtS: 54
GCID: GC18M044259

ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase...

(Previous names: sialyltransferase 8E (alpha-2, 8-polysialytransferase))
(Previous symbol: SIAT8E)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 51 2     ST8Sia V1
SIAT8E1 2 3 5     Alpha-2,8-Sialyltransferase 8E2
Sialyltransferase 8E (Alpha-2, 8-Polysialytransferase)1 2     Sialytransferase St8Sia V2
Sialyltransferase St8Sia V2 3     EC 2.4.99.-3
SIAT8-E2 3     Sialyltransferase 8E3
ST8SiaV2 3     

External Ids:    HGNC: 178271   Entrez Gene: 299062   Ensembl: ENSG000001016387   OMIM: 6071625   UniProtKB: O154663   

Export aliases for ST8SIA5 gene to outside databases

Previous GC identifers: GC18M042514 GC18M041116


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ST8SIA5 Gene:
The protein encoded by this gene is a type II membrane protein that may be present in the Golgi apparatus. The
encoded protein, which is a member of glycosyltransferase family 29, may be involved in the synthesis of
gangliosides GD1c, GT1a, GQ1b, and GT3 from GD1a, GT1b, GM1b, and GD3, respectively. (provided by RefSeq, Jul
2008)

GeneCards Summary for ST8SIA5 Gene:
ST8SIA5 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5) is a protein-coding gene. GO annotations related to this gene include alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity and sialyltransferase activity. An important paralog of this gene is ST8SIA1.

UniProtKB/Swiss-Prot: SIA8E_HUMAN, O15466
Function: May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3
respectively




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ST8SIA5 gene promoter:
         COUP-TF1   FOXF2   Bach2   MyoD   COUP   HNF-4alpha2   HNF-4alpha1   SREBP-1a   COUP-TF   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidST8SIA5 promoter sequence
   Search Chromatin IP Primers for ST8SIA5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST8SIA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.1   Ensembl cytogenetic band:  18q21.1   HGNC cytogenetic band: 18q12.3

ST8SIA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST8SIA5 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M044259:  view genomic region     (about GC identifiers)

Start:
44,259,081 bp from pter      End:
44,339,220 bp from pter
Size:
80,140 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIA8E_HUMAN, O15466 (See protein sequence)
Recommended Name: Alpha-2,8-sialyltransferase 8E  
Size: 376 amino acids; 43895 Da
Secondary accessions: Q6IAW7

Explore the universe of human proteins at neXtProt for ST8SIA5: NX_O15466

Explore proteomics data for ST8SIA5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn56, Asn96, Asn241, Asn284
  • Modification sites at PhosphoSitePlus

  • See ST8SIA5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037437.2  
    ENSEMBL proteins: 
     ENSP00000321343   ENSP00000445492   ENSP00000443683   ENSP00000468112   ENSP00000466787  
    Reactome Protein details: O15466

    ST8SIA5 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ST8SIA5 

    ST8SIA5 Antibody Products:

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    Search eBioscience for ELISAs for ST8SIA5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ST3G: Sialyltransferases

    2 InterPro protein domains:
     IPR001675 Glyco_trans_29
     IPR012163 Sialyl_trans

    Graphical View of Domain Structure for InterPro Entry O15466

    ProtoNet protein and cluster: O15466

    1 Blocks protein domain: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIA8E_HUMAN, O15466
    Similarity: Belongs to the glycosyltransferase 29 family


    Find genes that share domains with ST8SIA5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIA8E_HUMAN, O15466
    Function: May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3
    respectively

         Enzyme Number (IUBMB): EC 2.4.99.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003828alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IEA--
    GO:0008373sialyltransferase activity TAS9199191
         
    Find genes that share ontologies with ST8SIA5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ST8SIA5:
     Increased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ST8SIA5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ST8SIA5
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    miRNA
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    Block miRNA regulation of human, mouse, rat ST8SIA5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ST8SIA5 (see all 20):
    hsa-miR-301a hsa-miR-340 hsa-miR-218 hsa-miR-3125 hsa-miR-3916 hsa-miR-3605-5p hsa-miR-130b hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidST8SIA5 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ST8SIA5

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    GenScript: all cDNA clones in your preferred vector: ST8SIA5 (NM_013305)
    Sino Biological Human cDNA Clone for ST8SIA5
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST8SIA5

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST8SIA5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIA8E_HUMAN, O15466: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular3
    endoplasmic reticulum1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030173integral component of Golgi membrane IEA--

    Find genes that share ontologies with ST8SIA5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ST8SIA5 About    
    See pathways by source

    SuperPathContained pathways About
    1Glycosphingolipid biosynthesis - ganglio series
    Ganglio Sphingolipid Metabolism0.53
    Glycosphingolipid biosynthesis - ganglio series0.53
    2Metabolism
    Metabolic pathways0.38


    Find genes that share SuperPaths with ST8SIA5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ST8SIA5
        Ganglio Sphingolipid Metabolism


    1 Reactome Pathway for ST8SIA5
        Sialic acid metabolism


    2 Kegg Pathways  (Kegg details for ST8SIA5):
        Glycosphingolipid biosynthesis - ganglio series
    Metabolic pathways

    UniProtKB/Swiss-Prot: SIA8E_HUMAN, O15466
    Pathway: Protein modification; protein glycosylation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ST8SIA5
    Interactions:

        Search GeneGlobe Interaction Network for ST8SIA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for ST8SIA5 (ENSP000003213434) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    B4GALNT1ENSP000003415624STRING: ENSP00000341562
    ST3GAL1ENSP000003184454STRING: ENSP00000318445
    ST3GAL2ENSP000003454774STRING: ENSP00000345477
    ST6GALNAC3ENSP000003292144STRING: ENSP00000329214
    ST6GALNAC5ENSP000004175834STRING: ENSP00000417583
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS9199191
    GO:0006486protein glycosylation IEA--
    GO:0006688glycosphingolipid biosynthetic process TAS9199191
    GO:0097503sialylation TAS9199191

    Find genes that share ontologies with ST8SIA5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ST8SIA5 (SIA8E)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ST8SIA5 gene: 
    NM_013305.4  

    Unigene Cluster for ST8SIA5:

    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
    Hs.465025  [show with all ESTs]
    Unigene Representative Sequence: NM_013305
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315087(uc002lci.1 uc002lcj.1 uc010xcy.1 uc010xcz.1 uc010dno.1)
    ENST00000590497 ENST00000538168 ENST00000536490 ENST00000587428 ENST00000589088
    ENST00000591375 ENST00000588155 ENST00000590488
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ST8SIA5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ST8SIA5 (see all 20):
    hsa-miR-301a hsa-miR-340 hsa-miR-218 hsa-miR-3125 hsa-miR-3916 hsa-miR-3605-5p hsa-miR-130b hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidST8SIA5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ST8SIA5
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ST8SIA5 (NM_013305)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST8SIA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST8SIA5
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ST8SIA5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ST8SIA5
      QuantiTect SYBR Green Assays in human, mouse, rat ST8SIA5
      QuantiFast Probe-based Assays in human, mouse, rat ST8SIA5

    Additional mRNA sequence: 

    AK056270.1 AK094273.1 AK130126.1 AK293608.1 AK298881.1 AK310764.1 BC108910.1 BC108911.1 
    CR457037.1 U91641.1 

    3 DOTS entries:

    DT.207251  DT.121084713  DT.97768771 

    Selected AceView cDNA sequences (see all 29):

    AK094273 AK130126 NM_013305 BM679941 AW134945 AK056270 U91641 BF968902 
    U55966 CR457037 AW206911 BM723736 AW251085 AW250347 AU130750 AI692935 
    BE798786 BE041668 BF438207 AW162481 AW087114 AI689795 AW157019 AI681140 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ST8SIA5    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:                                                        -                 -               
    SP2:                    -     -     -                                         -               
    SP3:        -     -     -     -     -                                                         
    SP4:                    -     -                                                               
    SP5:                                                                                          


    ECgene alternative splicing isoforms for ST8SIA5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ST8SIA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGTCTTGGT
    ST8SIA5 Expression
    About this image


    ST8SIA5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Ovary (Reproductive System)
             Granulosa Cells Primary Follicle
     
     Skeletal Muscle (Muscoskeletal System)
    ST8SIA5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ST8SIA5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465025

    UniProtKB/Swiss-Prot: SIA8E_HUMAN, O15466
    Tissue specificity: Expressed in fetal and adult brain, adult heart and skeletal muscle

        Custom PCR Arrays for ST8SIA5
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    QuantiFast Probe-based Assays in human, mouse, rat ST8SIA5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST8SIA5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ST8SIA5 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St8sia51 , 5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more1, 5 85.55(n)1
    85.11(a)1
      18 (52.13 cM)5
    2257421  NM_013666.21  NP_038694.21 
     771858535 
    chicken
    (Gallus gallus)
    Aves ST8SIA51 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more 80.94(n)
    90.16(a)
      414797  XM_004949029.1  XP_004949086.1 
    lizard
    (Anolis carolinensis)
    Reptilia ST8SIA56
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltra...
    77(a)
    1 ↔ 1
    1(34481662-34539814)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia st8sia51 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more 77.03(n)
    83.91(a)
      100036735  NM_001097279.1  NP_001090748.1 
    zebrafish
    (Danio rerio)
    Actinopterygii st8sia51 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more 71.85(n)
    73.19(a)
      553754  NM_001204154.1  NP_001191083.1 


    ENSEMBL Gene Tree for ST8SIA5 (if available)
    TreeFam Gene Tree for ST8SIA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ST8SIA5 gene
    ST8SIA12  ST8SIA62  ST8SIA32  ST8SIA22  ST8SIA42  
    7 SIMAP similar genes for ST8SIA5 using alignment to 5 protein entries:     SIA8E_HUMAN (see all proteins):
    SIA8F    ST8SIA6    ST8SIA1    ST8Sia VI    ST8SIA4    ST8SIA2
    ST3GAL1

    Find genes that share paralogs with ST8SIA5           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ST8SIA5
    PGOHUM00000258704


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ST8SIA5 (see all 1630)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1468610801,2
    --44258583(+) AGAATA/GGGCTT 1 -- ds50010--------
    rs1154610431,2
    C,F--44258617(+) AGAAAA/GGAGGA 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1396788541,2
    --44258653(+) GGCAGA/GGAGAA 1 -- ds50010--------
    rs782723941,2
    C,F--44258900(+) CCAGGC/GCCTGG 1 -- ds50012Minor allele frequency- G:0.02NA 122
    rs577142741,2
    C--44258926(+) GTCCCG/ACCTTC 1 -- ds50014Minor allele frequency- A:0.11NA WA EA 360
    rs1510558021,2
    --44259031(+) AGCCTA/GTGGTT 1 -- ds50010--------
    rs1819599871,2
    --44259112(+) TAACTA/CCTGGT 1 -- ut310--------
    rs1861887081,2
    --44259279(+) CAAGAC/TCGCAT 1 -- ut310--------
    rs1409439101,2
    C--44259284(+) CCGCAC/TGTGTG 1 -- ut310--------
    rs1179285471,2
    F--44259524(+) TTCGAT/CATAAA 1 -- ut311Minor allele frequency- C:0.01NA 120

    HapMap Linkage Disequilibrium report for ST8SIA5 (44259081 - 44339220 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ST8SIA5 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509692CNV Insertion20534489
    dgv3413n71CNV Gain21882294
    nsv909604CNV Gain21882294
    nsv428355CNV Gain18775914
    dgv3415n71CNV Gain21882294
    dgv3412n71CNV Gain21882294
    dgv3414n71CNV Gain21882294
    esv25184CNV Gain19812545
    nsv515609CNV Gain19592680
    dgv3411n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ST8SIA5
    DNA2.0 Custom Variant and Variant Library Synthesis for ST8SIA5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607162    OMIM disorders: --


    Find genes that share disorders with ST8SIA5           About GenesLikeMe

    Genetic Association Database (GAD): ST8SIA5

    Export disorders for ST8SIA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ST8SIA5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ST8SIA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of human alpha2,8-sialyltransferase (hST8Sia V). (PubMed id 9199191)1, 2, 3 Kim Y.-J.... Lee Y.-C. (Biochem. Biophys. Res. Commun. 1997)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Ganglioside metabolism in a transgenic mouse model of Alzheimer's disease: expression of Chol-1I+ antigens in the brain. (PubMed id 20930939)1 Ariga T....Yu R.K. (ASN Neuro 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Isolation of chromosome 18-specific brain transcripts as positional candidates for bipolar disorder. (PubMed id 9129712)1 Yoshikawa T....Detera-Wadleigh S.D. (Am. J. Med. Genet. 1997)
    7. Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression. (PubMed id 16857734)9 Avril T....Crocker P.R. (J. Leukoc. Biol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29906 HGNC: 17827 AceView: SIAT8E Ensembl:ENSG00000101638 euGenes: HUgn29906
    ECgene: ST8SIA5 Kegg: 29906 H-InvDB: ST8SIA5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ST8SIA5 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST8SIA5
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_640

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ST8SIA5 gene:
    Search GeneIP for patents involving ST8SIA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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