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Aliases for ST8SIA5 Gene

Aliases for ST8SIA5 Gene

  • ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 5 2 3
  • Sialyltransferase 8E (Alpha-2, 8-Polysialytransferase) 2 3
  • Sialyltransferase St8Sia V 3 4
  • SIAT8-E 3 4
  • ST8SiaV 3 4
  • SIAT8E 3 4
  • Sialyltransferase 8E 4
  • EC 2.4.99.- 4
  • ST8Sia V 2

External Ids for ST8SIA5 Gene

Previous HGNC Symbols for ST8SIA5 Gene

  • SIAT8E

Previous GeneCards Identifiers for ST8SIA5 Gene

  • GC18M042514
  • GC18M044259
  • GC18M041116

Summaries for ST8SIA5 Gene

Entrez Gene Summary for ST8SIA5 Gene

  • The protein encoded by this gene is a type II membrane protein that may be present in the Golgi apparatus. The encoded protein, which is a member of glycosyltransferase family 29, may be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, and GT3 from GD1a, GT1b, GM1b, and GD3, respectively. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST8SIA5 Gene

ST8SIA5 (ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 5) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include sialyltransferase activity and alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. An important paralog of this gene is ST8SIA1.

UniProtKB/Swiss-Prot for ST8SIA5 Gene

  • May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST8SIA5 Gene

Genomics for ST8SIA5 Gene

Regulatory Elements for ST8SIA5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ST8SIA5 Gene

Chromosome:
18
Start:
46,667,821 bp from pter
End:
46,759,257 bp from pter
Size:
91,437 bases
Orientation:
Minus strand

Genomic View for ST8SIA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ST8SIA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST8SIA5 Gene

Proteins for ST8SIA5 Gene

  • Protein details for ST8SIA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15466-SIA8E_HUMAN
    Recommended name:
    Alpha-2,8-sialyltransferase 8E
    Protein Accession:
    O15466
    Secondary Accessions:
    • B7Z1K9
    • Q6IAW7

    Protein attributes for ST8SIA5 Gene

    Size:
    376 amino acids
    Molecular mass:
    43895 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ST8SIA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ST8SIA5 Gene

Proteomics data for ST8SIA5 Gene at MOPED

Post-translational modifications for ST8SIA5 Gene

  • Glycosylation at Asn 56, Asn 96, Asn 241, and Asn 284
  • Modification sites at PhosphoSitePlus

Other Protein References for ST8SIA5 Gene

No data available for DME Specific Peptides for ST8SIA5 Gene

Domains & Families for ST8SIA5 Gene

Gene Families for ST8SIA5 Gene

Protein Domains for ST8SIA5 Gene

Graphical View of Domain Structure for InterPro Entry

O15466

UniProtKB/Swiss-Prot:

SIA8E_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST8SIA5: view

Function for ST8SIA5 Gene

Molecular function for ST8SIA5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively.

Enzyme Numbers (IUBMB) for ST8SIA5 Gene

Gene Ontology (GO) - Molecular Function for ST8SIA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008373 sialyltransferase activity TAS 9199191
genes like me logo Genes that share ontologies with ST8SIA5: view
genes like me logo Genes that share phenotypes with ST8SIA5: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ST8SIA5

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ST8SIA5 Gene

Localization for ST8SIA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST8SIA5 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST8SIA5 Gene COMPARTMENTS Subcellular localization image for ST8SIA5 gene
Compartment Confidence
golgi apparatus 4

Gene Ontology (GO) - Cellular Components for ST8SIA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0030173 integral component of Golgi membrane IEA --
genes like me logo Genes that share ontologies with ST8SIA5: view

Pathways & Interactions for ST8SIA5 Gene

genes like me logo Genes that share pathways with ST8SIA5: view

UniProtKB/Swiss-Prot O15466-SIA8E_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for ST8SIA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 9199191
GO:0006486 protein glycosylation --
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006688 glycosphingolipid biosynthetic process TAS 9199191
GO:0018279 protein N-linked glycosylation via asparagine TAS --
genes like me logo Genes that share ontologies with ST8SIA5: view

No data available for SIGNOR curated interactions for ST8SIA5 Gene

Drugs & Compounds for ST8SIA5 Gene

No Compound Related Data Available

Transcripts for ST8SIA5 Gene

Unigene Clusters for ST8SIA5 Gene

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ST8SIA5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST8SIA5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5:

Relevant External Links for ST8SIA5 Gene

GeneLoc Exon Structure for
ST8SIA5
ECgene alternative splicing isoforms for
ST8SIA5

Expression for ST8SIA5 Gene

mRNA expression in normal human tissues for ST8SIA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST8SIA5 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.5), Adrenal Gland (x7.4), Brain - Cerebellum (x7.1), and Brain - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for ST8SIA5 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ST8SIA5 Gene



SOURCE GeneReport for Unigene cluster for ST8SIA5 Gene Hs.465025

mRNA Expression by UniProt/SwissProt for ST8SIA5 Gene

O15466-SIA8E_HUMAN
Tissue specificity: Expressed in fetal and adult brain, adult heart and skeletal muscle.
genes like me logo Genes that share expression patterns with ST8SIA5: view

Protein tissue co-expression partners for ST8SIA5 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for ST8SIA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST8SIA5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ST8SIA5 35
  • 94.24 (n)
  • 98.67 (a)
ST8SIA5 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ST8SIA5 35
  • 93.6 (n)
  • 98.68 (a)
ST8SIA5 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St8sia5 35
  • 85.55 (n)
  • 85.11 (a)
St8sia5 16
St8sia5 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ST8SIA5 35
  • 99.2 (n)
  • 99.73 (a)
ST8SIA5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia St8sia5 35
  • 86.79 (n)
  • 84.84 (a)
oppossum
(Monodelphis domestica)
Mammalia ST8SIA5 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ST8SIA5 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves ST8SIA5 35
  • 80.94 (n)
  • 90.16 (a)
ST8SIA5 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST8SIA5 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st8sia5 35
  • 77.03 (n)
  • 83.91 (a)
zebrafish
(Danio rerio)
Actinopterygii st8sia5 35
  • 71.85 (n)
  • 73.19 (a)
st8sia5 36
  • 62 (a)
OneToOne
Species with no ortholog for ST8SIA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST8SIA5 Gene

ENSEMBL:
Gene Tree for ST8SIA5 (if available)
TreeFam:
Gene Tree for ST8SIA5 (if available)

Paralogs for ST8SIA5 Gene

Paralogs for ST8SIA5 Gene

(7) SIMAP similar genes for ST8SIA5 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ST8SIA5 Gene

genes like me logo Genes that share paralogs with ST8SIA5: view

Variants for ST8SIA5 Gene

Sequence variations from dbSNP and Humsavar for ST8SIA5 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs328112 -- 46,699,659(-) GCTCA(A/C/T)GCCTG intron-variant
rs328113 -- 46,693,162(+) cctac(A/C/T)gtacc intron-variant
rs328114 -- 46,693,823(+) CAGCA(A/G)TGCCT intron-variant
rs328115 -- 46,696,201(+) TGGCT(C/G)ACAGA intron-variant
rs328116 -- 46,686,536(+) CCTCC(C/T)GGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST8SIA5 Gene

Variant ID Type Subtype PubMed ID
nsv428355 CNV Gain 18775914
esv259974 OTHER Complex 20981092
esv25184 CNV Gain 19812545
nsv515609 CNV Gain 19592680
nsv9629 CNV Gain+Loss 18304495
dgv3411n71 CNV Gain 21882294
dgv3412n71 CNV Gain 21882294
dgv3413n71 CNV Gain 21882294
dgv3414n71 CNV Gain 21882294
nsv909604 CNV Gain 21882294
nsv509692 CNV Insertion 20534489
dgv3415n71 CNV Gain 21882294

Variation tolerance for ST8SIA5 Gene

Residual Variation Intolerance Score: 23.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ST8SIA5 Gene

HapMap Linkage Disequilibrium report
ST8SIA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST8SIA5 Gene

Disorders for ST8SIA5 Gene

Relevant External Links for ST8SIA5

Genetic Association Database (GAD)
ST8SIA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ST8SIA5
genes like me logo Genes that share disorders with ST8SIA5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST8SIA5 Gene

Publications for ST8SIA5 Gene

  1. Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression. (PMID: 16857734) Avril T. … Crocker P.R. (J. Leukoc. Biol. 2006) 23 67
  2. Molecular cloning and expression of human alpha2,8-sialyltransferase (hST8Sia V). (PMID: 9199191) Kim Y.-J. … Lee Y.-C. (Biochem. Biophys. Res. Commun. 1997) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. Ganglioside metabolism in a transgenic mouse model of Alzheimer's disease: expression of Chol-1I+ antigens in the brain. (PMID: 20930939) Ariga T. … Yu R.K. (ASN Neuro 2010) 67

Products for ST8SIA5 Gene

Sources for ST8SIA5 Gene

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