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Aliases for ST8SIA5 Gene

Aliases for ST8SIA5 Gene

  • ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 5 2 3 5
  • ST8 Alpha-N-Acetylneuraminate Alpha-2,8-Sialyltransferase 5 2 3
  • Sialyltransferase 8E (Alpha-2, 8-Polysialytransferase) 2 3
  • Sialyltransferase St8Sia V 3 4
  • SIAT8-E 3 4
  • ST8SiaV 3 4
  • SIAT8E 3 4
  • Alpha-2,8-Sialyltransferase 8E 3
  • Sialyltransferase 8E 4
  • EC 2.4.99.- 4
  • ST8Sia V 2

External Ids for ST8SIA5 Gene

Previous HGNC Symbols for ST8SIA5 Gene

  • SIAT8E

Previous GeneCards Identifiers for ST8SIA5 Gene

  • GC18M042514
  • GC18M044259
  • GC18M041116

Summaries for ST8SIA5 Gene

Entrez Gene Summary for ST8SIA5 Gene

  • The protein encoded by this gene is a type II membrane protein that may be present in the Golgi apparatus. The encoded protein, which is a member of glycosyltransferase family 29, may be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, and GT3 from GD1a, GT1b, GM1b, and GD3, respectively. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST8SIA5 Gene

ST8SIA5 (ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 5) is a Protein Coding gene. Among its related pathways are Synthesis of substrates in N-glycan biosythesis and Glycosphingolipid biosynthesis - ganglio series. GO annotations related to this gene include sialyltransferase activity and alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. An important paralog of this gene is ST8SIA6.

UniProtKB/Swiss-Prot for ST8SIA5 Gene

  • May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST8SIA5 Gene

Genomics for ST8SIA5 Gene

Regulatory Elements for ST8SIA5 Gene

Enhancers for ST8SIA5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G046710 1.1 ENCODE dbSUPER 19.4 +47.3 47289 2.7 HDAC1 PKNOX1 ATF1 TBL1XR1 TCF12 GATA2 ZNF366 CREM MEF2D NFIC ST8SIA5 PIAS2 RPS21P6 LOC105372096
GH18G046675 0.9 ENCODE dbSUPER 10.6 +82.6 82609 3.2 ZNF263 CTCF ZNF792 JUN CEBPB FEZF1 RAD21 ZFHX2 ZNF26 FOXP2 HAUS1 ST8SIA5 LOC105372096 RPS21P6
GH18G046718 1.1 Ensembl ENCODE dbSUPER 4.9 +40.4 40376 1.6 JUND GATA2 ZNF366 JUN U2AF1 FOS U2AF2 ST8SIA5 RPS21P6 LOC105372096
GH18G046671 0.4 dbSUPER 10.1 +86.7 86681 1.2 RFX1 MAX ST8SIA5 LOC105372096 RPS21P6
GH18G046702 0.2 dbSUPER 18.3 +56.6 56646 1.2 ST8SIA5 RPS21P6 LOC105372096
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ST8SIA5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ST8SIA5 Gene

Chromosome:
18
Start:
46,667,821 bp from pter
End:
46,759,257 bp from pter
Size:
91,437 bases
Orientation:
Minus strand

Genomic View for ST8SIA5 Gene

Genes around ST8SIA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST8SIA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST8SIA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST8SIA5 Gene

Proteins for ST8SIA5 Gene

  • Protein details for ST8SIA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15466-SIA8E_HUMAN
    Recommended name:
    Alpha-2,8-sialyltransferase 8E
    Protein Accession:
    O15466
    Secondary Accessions:
    • B7Z1K9
    • Q6IAW7

    Protein attributes for ST8SIA5 Gene

    Size:
    376 amino acids
    Molecular mass:
    43895 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ST8SIA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ST8SIA5 Gene

Post-translational modifications for ST8SIA5 Gene

  • Glycosylation at posLast=5656, posLast=9696, isoforms=2241, and posLast=284284
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ST8SIA5 Gene

Domains & Families for ST8SIA5 Gene

Gene Families for ST8SIA5 Gene

Protein Domains for ST8SIA5 Gene

Graphical View of Domain Structure for InterPro Entry

O15466

UniProtKB/Swiss-Prot:

SIA8E_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST8SIA5: view

Function for ST8SIA5 Gene

Molecular function for ST8SIA5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively.

Enzyme Numbers (IUBMB) for ST8SIA5 Gene

Gene Ontology (GO) - Molecular Function for ST8SIA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0008373 sialyltransferase activity IEA,TAS 9199191
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ST8SIA5: view
genes like me logo Genes that share phenotypes with ST8SIA5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ST8SIA5 Gene

Localization for ST8SIA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST8SIA5 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST8SIA5 gene
Compartment Confidence
golgi apparatus 5
extracellular 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ST8SIA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030173 integral component of Golgi membrane IEA --
genes like me logo Genes that share ontologies with ST8SIA5: view

Pathways & Interactions for ST8SIA5 Gene

genes like me logo Genes that share pathways with ST8SIA5: view

UniProtKB/Swiss-Prot O15466-SIA8E_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for ST8SIA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 9199191
GO:0006486 protein glycosylation IEA --
GO:0006688 glycosphingolipid biosynthetic process TAS 9199191
GO:0097503 sialylation IEA --
genes like me logo Genes that share ontologies with ST8SIA5: view

No data available for SIGNOR curated interactions for ST8SIA5 Gene

Drugs & Compounds for ST8SIA5 Gene

No Compound Related Data Available

Transcripts for ST8SIA5 Gene

Unigene Clusters for ST8SIA5 Gene

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST8SIA5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5:

Relevant External Links for ST8SIA5 Gene

GeneLoc Exon Structure for
ST8SIA5
ECgene alternative splicing isoforms for
ST8SIA5

Expression for ST8SIA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST8SIA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST8SIA5 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.5), Adrenal Gland (x7.4), Brain - Cerebellum (x7.1), and Brain - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for ST8SIA5 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ST8SIA5 Gene



Protein tissue co-expression partners for ST8SIA5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ST8SIA5 Gene:

ST8SIA5

SOURCE GeneReport for Unigene cluster for ST8SIA5 Gene:

Hs.465025

mRNA Expression by UniProt/SwissProt for ST8SIA5 Gene:

O15466-SIA8E_HUMAN
Tissue specificity: Expressed in fetal and adult brain, adult heart and skeletal muscle.

Evidence on tissue expression from TISSUES for ST8SIA5 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ST8SIA5: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ST8SIA5 Gene

Orthologs for ST8SIA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST8SIA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST8SIA5 34 35
  • 99.2 (n)
cow
(Bos Taurus)
Mammalia ST8SIA5 34 35
  • 94.24 (n)
dog
(Canis familiaris)
Mammalia ST8SIA5 34 35
  • 93.6 (n)
rat
(Rattus norvegicus)
Mammalia St8sia5 34
  • 86.79 (n)
mouse
(Mus musculus)
Mammalia St8sia5 34 16 35
  • 85.55 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ST8SIA5 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ST8SIA5 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves ST8SIA5 34 35
  • 80.94 (n)
lizard
(Anolis carolinensis)
Reptilia ST8SIA5 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st8sia5 34
  • 77.03 (n)
zebrafish
(Danio rerio)
Actinopterygii st8sia5 34 35
  • 71.85 (n)
Species where no ortholog for ST8SIA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST8SIA5 Gene

ENSEMBL:
Gene Tree for ST8SIA5 (if available)
TreeFam:
Gene Tree for ST8SIA5 (if available)

Paralogs for ST8SIA5 Gene

Paralogs for ST8SIA5 Gene

(7) SIMAP similar genes for ST8SIA5 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ST8SIA5 Gene

genes like me logo Genes that share paralogs with ST8SIA5: view

Variants for ST8SIA5 Gene

Sequence variations from dbSNP and Humsavar for ST8SIA5 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000000329 -- 46,694,971(+) CTGGC(C/G)AACAT intron-variant
rs1000001131 -- 46,734,632(+) GACTG(A/G)AGCCC intron-variant
rs1000003879 -- 46,710,404(+) CTTTC(-/TTTCTTTCTTTCTTTT)TCTTT intron-variant
rs1000033780 -- 46,734,373(+) AGAGA(A/C)CCCCA intron-variant
rs1000036476 -- 46,710,147(+) CCACT(C/T)AGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST8SIA5 Gene

Variant ID Type Subtype PubMed ID
dgv3345n100 CNV gain 25217958
dgv614e214 CNV gain 21293372
esv25184 CNV gain 19812545
esv3303000 CNV tandem duplication 20981092
esv3397234 CNV duplication 20981092
esv3642438 CNV gain 21293372
esv3642441 CNV gain 21293372
nsv428355 CNV gain 18775914
nsv509692 CNV insertion 20534489
nsv515609 CNV gain 19592680
nsv953536 CNV deletion 24416366
nsv9629 CNV gain+loss 18304495

Variation tolerance for ST8SIA5 Gene

Residual Variation Intolerance Score: 23.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ST8SIA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST8SIA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST8SIA5 Gene

Disorders for ST8SIA5 Gene

Relevant External Links for ST8SIA5

Genetic Association Database (GAD)
ST8SIA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ST8SIA5

No disorders were found for ST8SIA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST8SIA5 Gene

Publications for ST8SIA5 Gene

  1. Molecular cloning and expression of human alpha2,8-sialyltransferase (hST8Sia V). (PMID: 9199191) Kim Y.-J. … Lee Y.-C. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Ganglioside metabolism in a transgenic mouse model of Alzheimer's disease: expression of Chol-1I+ antigens in the brain. (PMID: 20930939) Ariga T. … Yu R.K. (ASN Neuro 2010) 3 64

Products for ST8SIA5 Gene

Sources for ST8SIA5 Gene

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