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Aliases for ST8SIA4 Gene

Aliases for ST8SIA4 Gene

  • ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 4 2 3 5
  • ST8 Alpha-N-Acetylneuraminate Alpha-2,8-Sialyltransferase 4 2 3
  • Sialyltransferase 8 (Alpha-2, 8-Polysialytransferase) D 2 3
  • Alpha-2,8-Sialyltransferase 8D 3 4
  • Sialyltransferase St8Sia IV 3 4
  • Polysialyltransferase-1 3 4
  • Sialyltransferase 8D 3 4
  • ST8SiaIV 3 4
  • SIAT8-D 3 4
  • SIAT8D 3 4
  • PST1 3 4
  • PST 3 4
  • CMP-N-Acetylneuraminate-Poly-Alpha-2,8-Sialyl Transferase 3
  • Sialytransferase St8Sia IV 3
  • EC 2.4.99.- 4
  • ST8Sia IV 2
  • ST8SIA-IV 3
  • EC 2.4.99 63

External Ids for ST8SIA4 Gene

Previous HGNC Symbols for ST8SIA4 Gene

  • SIAT8D

Previous GeneCards Identifiers for ST8SIA4 Gene

  • GC05M100171
  • GC05M095326

Summaries for ST8SIA4 Gene

Entrez Gene Summary for ST8SIA4 Gene

  • The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST8SIA4 Gene

ST8SIA4 (ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 4) is a Protein Coding gene. Diseases associated with ST8SIA4 include Granuloma Inguinale. Among its related pathways are Developmental Biology and Transport to the Golgi and subsequent modification. GO annotations related to this gene include sialyltransferase activity and alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. An important paralog of this gene is ST8SIA1.

UniProtKB/Swiss-Prot for ST8SIA4 Gene

  • Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells.

Gene Wiki entry for ST8SIA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST8SIA4 Gene

Genomics for ST8SIA4 Gene

Regulatory Elements for ST8SIA4 Gene

Enhancers for ST8SIA4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ST8SIA4 on UCSC Golden Path with GeneCards custom track

Promoters for ST8SIA4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ST8SIA4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ST8SIA4 Gene

Chromosome:
5
Start:
100,806,935 bp from pter
End:
100,903,285 bp from pter
Size:
96,351 bases
Orientation:
Minus strand

Genomic View for ST8SIA4 Gene

Genes around ST8SIA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST8SIA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST8SIA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST8SIA4 Gene

Proteins for ST8SIA4 Gene

  • Protein details for ST8SIA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92187-SIA8D_HUMAN
    Recommended name:
    CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase
    Protein Accession:
    Q92187
    Secondary Accessions:
    • A8KA07
    • G3V104
    • Q8N1F4
    • Q92693

    Protein attributes for ST8SIA4 Gene

    Size:
    359 amino acids
    Molecular mass:
    41295 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ST8SIA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ST8SIA4 Gene

Proteomics data for ST8SIA4 Gene at MOPED

Post-translational modifications for ST8SIA4 Gene

  • Glycosylation at Asn 50, Asn 74, Asn 119, Asn 204, Asn 219, and Asn 327
  • Modification sites at PhosphoSitePlus

Other Protein References for ST8SIA4 Gene

Antibody Products

  • Abcam antibodies for SIA8D

Domains & Families for ST8SIA4 Gene

Gene Families for ST8SIA4 Gene

Protein Domains for ST8SIA4 Gene

Suggested Antigen Peptide Sequences for ST8SIA4 Gene

Graphical View of Domain Structure for InterPro Entry

Q92187

UniProtKB/Swiss-Prot:

SIA8D_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST8SIA4: view

Function for ST8SIA4 Gene

Molecular function for ST8SIA4 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells.

Enzyme Numbers (IUBMB) for ST8SIA4 Gene

Gene Ontology (GO) - Molecular Function for ST8SIA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA,TAS --
GO:0033691 sialic acid binding IC 10766765
genes like me logo Genes that share ontologies with ST8SIA4: view
genes like me logo Genes that share phenotypes with ST8SIA4: view

Animal Models for ST8SIA4 Gene

MGI Knock Outs for ST8SIA4:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ST8SIA4 Gene

Localization for ST8SIA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST8SIA4 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST8SIA4 Gene COMPARTMENTS Subcellular localization image for ST8SIA4 gene
Compartment Confidence
golgi apparatus 5
mitochondrion 2
cytosol 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for ST8SIA4 Gene

Pathways & Interactions for ST8SIA4 Gene

genes like me logo Genes that share pathways with ST8SIA4: view

UniProtKB/Swiss-Prot Q92187-SIA8D_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for ST8SIA4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000231461%0d%0a9606.ENSP00000358565%0d%0a9606.ENSP00000318472%0d%0a
Selected Interacting proteins: ENSP00000231461 Q92187-SIA8D_HUMAN for ST8SIA4 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ST8SIA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001574 ganglioside biosynthetic process IDA 10766765
GO:0006464 cellular protein modification process TAS 7854457
GO:0006486 protein glycosylation IEA,IDA 10766765
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0007399 nervous system development TAS 9054414
genes like me logo Genes that share ontologies with ST8SIA4: view

No data available for SIGNOR curated interactions for ST8SIA4 Gene

Drugs & Compounds for ST8SIA4 Gene

(1) Drugs for ST8SIA4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for ST8SIA4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ST8SIA4: view

Transcripts for ST8SIA4 Gene

Unigene Clusters for ST8SIA4 Gene

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ST8SIA4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6
SP1: - -
SP2:
SP3: -

Relevant External Links for ST8SIA4 Gene

GeneLoc Exon Structure for
ST8SIA4
ECgene alternative splicing isoforms for
ST8SIA4

Expression for ST8SIA4 Gene

mRNA expression in normal human tissues for ST8SIA4 Gene

mRNA differential expression in normal tissues according to GTEx for ST8SIA4 Gene

This gene is overexpressed in Whole Blood (x13.6).

Protein differential expression in normal tissues from HIPED for ST8SIA4 Gene

This gene is overexpressed in Blymphocyte (44.6) and Neutrophil (17.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ST8SIA4 Gene



SOURCE GeneReport for Unigene cluster for ST8SIA4 Gene Hs.308628

mRNA Expression by UniProt/SwissProt for ST8SIA4 Gene

Q92187-SIA8D_HUMAN
Tissue specificity: Highly expressed in fetal brain, lung and kidney and in adult heart, spleen and thymus. Present to a lesser extent in adult brain, placenta, lung, large and small intestine and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with ST8SIA4: view

Protein tissue co-expression partners for ST8SIA4 Gene

Primer Products

Orthologs for ST8SIA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST8SIA4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ST8SIA4 35
  • 93.13 (n)
  • 98.61 (a)
ST8SIA4 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ST8SIA4 35
  • 94.89 (n)
  • 99.16 (a)
ST8SIA4 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St8sia4 35
  • 91.74 (n)
  • 97.77 (a)
St8sia4 16
St8sia4 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ST8SIA4 35
  • 99.91 (n)
  • 100 (a)
ST8SIA4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia St8sia4 35
  • 90.06 (n)
  • 97.77 (a)
oppossum
(Monodelphis domestica)
Mammalia ST8SIA4 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ST8SIA4 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ST8SIA4 35
  • 85.61 (n)
  • 93.31 (a)
ST8SIA4 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST8SIA4 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st8sia4 35
  • 79.48 (n)
  • 87.74 (a)
zebrafish
(Danio rerio)
Actinopterygii st8sia4 35
  • 64.97 (n)
  • 70.06 (a)
st8sia4 36
  • 69 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11824 35
Species with no ortholog for ST8SIA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST8SIA4 Gene

ENSEMBL:
Gene Tree for ST8SIA4 (if available)
TreeFam:
Gene Tree for ST8SIA4 (if available)

Paralogs for ST8SIA4 Gene

Paralogs for ST8SIA4 Gene

(6) SIMAP similar genes for ST8SIA4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ST8SIA4: view

Variants for ST8SIA4 Gene

Sequence variations from dbSNP and Humsavar for ST8SIA4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_036169 A colorectal cancer sample
rs199768560 - 100,902,936(+) TCCAC(C/T)TCTTC reference, missense
rs726971 -- 100,846,602(-) AGTTT(C/T)AATTG intron-variant
rs3076 -- 100,811,694(+) TATTT(C/T)ATCAG utr-variant-3-prime
rs11584 -- 100,809,684(+) TTATT(A/C)AGTAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ST8SIA4 Gene

Variant ID Type Subtype PubMed ID
nsv882471 CNV Loss 21882294
dgv6238n71 CNV Loss 21882294

Variation tolerance for ST8SIA4 Gene

Residual Variation Intolerance Score: 23.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ST8SIA4 Gene

Disorders for ST8SIA4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ST8SIA4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
granuloma inguinale
  • donovanosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ST8SIA4

Genetic Association Database (GAD)
ST8SIA4
Human Genome Epidemiology (HuGE) Navigator
ST8SIA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ST8SIA4
genes like me logo Genes that share disorders with ST8SIA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST8SIA4 Gene

Publications for ST8SIA4 Gene

  1. Expression cloning of a human polysialyltransferase that forms the polysialylated neural cell adhesion molecule present in embryonic brain. (PMID: 7624364) Nakayama J. … Fukuda M. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 67
  2. N-CAM dysfunction and unexpected accumulation of PSA-NCAM in brain of adult-onset autosomal-dominant leukodystrophy. (PMID: 19725832) Piccinini M. … Rinaudo M.T. (Brain Pathol. 2010) 3 23
  3. Identification of sequences in the polysialyltransferases ST8Sia II and ST8Sia IV that are required for the protein-specific polysialylation of the neural cell adhesion molecule, NCAM. (PMID: 19336400) Foley D.A. … Colley K.J. (J. Biol. Chem. 2009) 3 23
  4. Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia. (PMID: 16229822) Arai M. … Itokawa M. (Biol. Psychiatry 2006) 3 23
  5. Molecular characterization of pig ST8Sia IV--a critical gene for the formation of neural cell adhesion molecule and its response to sialic acid supplement in piglets. (PMID: 17176637) Wang B. … Yu B. (Nutr Neurosci 2006) 3 23

Products for ST8SIA4 Gene

Sources for ST8SIA4 Gene

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