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Aliases for ST8SIA4 Gene

Aliases for ST8SIA4 Gene

  • ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 4 2 3
  • Sialyltransferase 8 (Alpha-2, 8-Polysialytransferase) D 2 3
  • Alpha-2,8-Sialyltransferase 8D 3 4
  • Sialyltransferase St8Sia IV 3 4
  • Polysialyltransferase-1 3 4
  • Sialyltransferase 8D 3 4
  • ST8SiaIV 3 4
  • SIAT8-D 3 4
  • SIAT8D 3 4
  • PST1 3 4
  • PST 3 4
  • CMP-N-Acetylneuraminate-Poly-Alpha-2,8-Sialyl Transferase 3
  • Sialytransferase St8Sia IV 3
  • EC 2.4.99.- 4
  • ST8Sia IV 2
  • ST8SIA-IV 3
  • EC 2.4.99 63

External Ids for ST8SIA4 Gene

Previous HGNC Symbols for ST8SIA4 Gene

  • SIAT8D

Previous GeneCards Identifiers for ST8SIA4 Gene

  • GC05M100171
  • GC05M095326

Summaries for ST8SIA4 Gene

Entrez Gene Summary for ST8SIA4 Gene

  • The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST8SIA4 Gene

ST8SIA4 (ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 4) is a Protein Coding gene. Diseases associated with ST8SIA4 include granuloma inguinale. Among its related pathways are Developmental Biology and Interleukin receptor SHC signaling. GO annotations related to this gene include sialyltransferase activity and alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. An important paralog of this gene is ST8SIA1.

UniProtKB/Swiss-Prot for ST8SIA4 Gene

  • Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells

Gene Wiki entry for ST8SIA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST8SIA4 Gene

Genomics for ST8SIA4 Gene

Regulatory Elements for ST8SIA4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ST8SIA4 Gene

Chromosome:
5
Start:
100,806,935 bp from pter
End:
100,903,285 bp from pter
Size:
96,351 bases
Orientation:
Minus strand

Genomic View for ST8SIA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ST8SIA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST8SIA4 Gene

Proteins for ST8SIA4 Gene

  • Protein details for ST8SIA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92187-SIA8D_HUMAN
    Recommended name:
    CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase
    Protein Accession:
    Q92187
    Secondary Accessions:
    • A8KA07
    • G3V104
    • Q8N1F4
    • Q92693

    Protein attributes for ST8SIA4 Gene

    Size:
    359 amino acids
    Molecular mass:
    41295 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ST8SIA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ST8SIA4 Gene

Proteomics data for ST8SIA4 Gene at MOPED

Post-translational modifications for ST8SIA4 Gene

  • Glycosylation at Asn 50, Asn 74, Asn 119, Asn 204, Asn 219, and Asn 327
  • Modification sites at PhosphoSitePlus

Other Protein References for ST8SIA4 Gene

Antibody Products

Domains & Families for ST8SIA4 Gene

Gene Families for ST8SIA4 Gene

Protein Domains for ST8SIA4 Gene

Suggested Antigen Peptide Sequences for ST8SIA4 Gene

Graphical View of Domain Structure for InterPro Entry

Q92187

UniProtKB/Swiss-Prot:

SIA8D_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST8SIA4: view

Function for ST8SIA4 Gene

Molecular function for ST8SIA4 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells

Enzyme Numbers (IUBMB) for ST8SIA4 Gene

Gene Ontology (GO) - Molecular Function for ST8SIA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA 10766765
GO:0008373 sialyltransferase activity --
GO:0033691 sialic acid binding IC 10766765
genes like me logo Genes that share ontologies with ST8SIA4: view
genes like me logo Genes that share phenotypes with ST8SIA4: view

Animal Models for ST8SIA4 Gene

MGI Knock Outs for ST8SIA4:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ST8SIA4

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for ST8SIA4 Gene

Localization for ST8SIA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST8SIA4 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST8SIA4 Gene COMPARTMENTS Subcellular localization image for ST8SIA4 gene
Compartment Confidence
golgi apparatus 4

Gene Ontology (GO) - Cellular Components for ST8SIA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0030173 integral component of Golgi membrane IEA --
genes like me logo Genes that share ontologies with ST8SIA4: view

Pathways & Interactions for ST8SIA4 Gene

genes like me logo Genes that share pathways with ST8SIA4: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q92187-SIA8D_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for ST8SIA4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000231461%0d%0a9606.ENSP00000358565%0d%0a9606.ENSP00000318472%0d%0a
Selected Interacting proteins: Q92187-SIA8D_HUMAN ENSP00000231461 for ST8SIA4 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for ST8SIA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001574 ganglioside biosynthetic process IDA 10766765
GO:0006464 cellular protein modification process TAS 7854457
GO:0006486 protein glycosylation IDA 10766765
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006491 N-glycan processing IDA 10766765
genes like me logo Genes that share ontologies with ST8SIA4: view

No data available for SIGNOR curated interactions for ST8SIA4 Gene

Drugs & Compounds for ST8SIA4 Gene

(1) Drugs for ST8SIA4 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Valproic Acid Approved, Investigational Pharma HDAC1 inhibitor, Histone deacetylase (HDAC)inhibitors 302

(3) Additional Compounds for ST8SIA4 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Galactose
polysaccharide
sialic acid
genes like me logo Genes that share compounds with ST8SIA4: view

Transcripts for ST8SIA4 Gene

Unigene Clusters for ST8SIA4 Gene

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ST8SIA4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST8SIA4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6
SP1: - -
SP2:
SP3: -

Relevant External Links for ST8SIA4 Gene

GeneLoc Exon Structure for
ST8SIA4
ECgene alternative splicing isoforms for
ST8SIA4

Expression for ST8SIA4 Gene

mRNA expression in normal human tissues for ST8SIA4 Gene

mRNA differential expression in normal tissues according to GTEx for ST8SIA4 Gene

This gene is overexpressed in Whole Blood (x13.6).

Protein differential expression in normal tissues from HIPED for ST8SIA4 Gene

This gene is overexpressed in Blymphocyte (44.6) and Neutrophil (17.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ST8SIA4 Gene



SOURCE GeneReport for Unigene cluster for ST8SIA4 Gene Hs.308628

mRNA Expression by UniProt/SwissProt for ST8SIA4 Gene

Q92187-SIA8D_HUMAN
Tissue specificity: Highly expressed in fetal brain, lung and kidney and in adult heart, spleen and thymus. Present to a lesser extent in adult brain, placenta, lung, large and small intestine and peripheral blood leukocytes
genes like me logo Genes that share expression patterns with ST8SIA4: view

Protein tissue co-expression partners for ST8SIA4 Gene

Primer Products

In Situ Assay Products

Orthologs for ST8SIA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST8SIA4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ST8SIA4 35
  • 93.13 (n)
  • 98.61 (a)
ST8SIA4 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ST8SIA4 35
  • 94.89 (n)
  • 99.16 (a)
ST8SIA4 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St8sia4 35
  • 91.74 (n)
  • 97.77 (a)
St8sia4 16
St8sia4 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ST8SIA4 35
  • 99.91 (n)
  • 100 (a)
ST8SIA4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia St8sia4 35
  • 90.06 (n)
  • 97.77 (a)
oppossum
(Monodelphis domestica)
Mammalia ST8SIA4 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ST8SIA4 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ST8SIA4 35
  • 85.61 (n)
  • 93.31 (a)
ST8SIA4 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST8SIA4 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st8sia4 35
  • 79.48 (n)
  • 87.74 (a)
zebrafish
(Danio rerio)
Actinopterygii st8sia4 35
  • 64.97 (n)
  • 70.06 (a)
st8sia4 36
  • 69 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11824 35
Species with no ortholog for ST8SIA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST8SIA4 Gene

ENSEMBL:
Gene Tree for ST8SIA4 (if available)
TreeFam:
Gene Tree for ST8SIA4 (if available)

Paralogs for ST8SIA4 Gene

Paralogs for ST8SIA4 Gene

(6) SIMAP similar genes for ST8SIA4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ST8SIA4: view

Variants for ST8SIA4 Gene

Sequence variations from dbSNP and Humsavar for ST8SIA4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_036169 A colorectal cancer sample
VAR_068976 -

Structural Variations from Database of Genomic Variants (DGV) for ST8SIA4 Gene

Variant ID Type Subtype PubMed ID
nsv882471 CNV Loss 21882294
dgv6238n71 CNV Loss 21882294

Variation tolerance for ST8SIA4 Gene

Residual Variation Intolerance Score: 23.21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ST8SIA4 Gene

HapMap Linkage Disequilibrium report
ST8SIA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST8SIA4 Gene

Disorders for ST8SIA4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ST8SIA4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
granuloma inguinale
  • donovanosis
- elite association

Relevant External Links for ST8SIA4

Genetic Association Database (GAD)
ST8SIA4
Human Genome Epidemiology (HuGE) Navigator
ST8SIA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ST8SIA4
genes like me logo Genes that share disorders with ST8SIA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST8SIA4 Gene

Publications for ST8SIA4 Gene

  1. N-CAM dysfunction and unexpected accumulation of PSA-NCAM in brain of adult-onset autosomal-dominant leukodystrophy. (PMID: 19725832) Piccinini M. … Rinaudo M.T. (Brain Pathol. 2010) 23 67
  2. Polysialic acid affects pathophysiological consequences of status epilepticus. (PMID: 20351597) Pekcec A. … Potschka H. (Neuroreport 2010) 23 67
  3. Identification of sequences in the polysialyltransferases ST8Sia II and ST8Sia IV that are required for the protein-specific polysialylation of the neural cell adhesion molecule, NCAM. (PMID: 19336400) Foley D.A. … Colley K.J. (J. Biol. Chem. 2009) 23 67
  4. Interaction of polysialic acid with CCL21 regulates the migratory capacity of human dendritic cells. (PMID: 19750015) Bax M. … van Kooyk Y. (PLoS ONE 2009) 23 67
  5. Transcriptional regulation of PSA-NCAM expression by NMDA receptor activation in RA-differentiated C6 glioma cultures. (PMID: 19429186) Singh J. … Kaur G. (Brain Res. Bull. 2009) 23 67

Products for ST8SIA4 Gene

Sources for ST8SIA4 Gene

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