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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ST8SIA4 Gene

protein-coding GIFtS: 59
GCID: GC05M100171

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase...

(Previous names: sialyltransferase 8 (alpha-2, 8-polysialytransferase) D...)
(Previous symbol: SIAT8D)

Explore 7 diseases affiliated with
ST8SIA4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 4¹ ²		ST8SiaIV² ³
PST¹ ² ³ ⁵		CMP-N-Acetylneuraminate-Poly-Alpha-2,8-Sialyltransferase¹
PST1¹ ² ³ ⁵		ST8SIA-IV²
SIAT8D¹ ² ³		CMP-N-Acetylneuraminate-Poly-Alpha-2,8-Sialyl Transferase²
Sialyltransferase 8 (Alpha-2, 8-Polysialytransferase) D¹ ²		Polysialyltransferase-1³
Alpha-2,8-Sialyltransferase 8D² ³		Sialytransferase St8Sia IV²
Sialyltransferase 8D² ³		EC 2.4.99.-³
Sialyltransferase St8Sia IV² ³		Polysialyltransferase-1³
SIAT8-D² ³		EC 2.4.99⁸

External Ids:	HGNC: 10871¹	Entrez Gene: 7903²	Ensembl: ENSG00000113532⁷	OMIM: 602547⁵	UniProtKB: Q92187³

Export aliases for ST8SIA4 gene to outside databases

Previous GC identifer: GC05M095326

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ST8SIA4:

The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the

synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The

encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present

in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. (provided

by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SIA8D_HUMAN, Q92187

Function: Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid

(PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural

cells

Gene Wiki entry for ST8SIA4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ST8SIA4 gene promoter:
Nkx3-1 POU2F1 AML1a POU2F1a CUTL1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ST8SIA4 promoter sequence

Search SABiosciences Chromatin IP Primers for ST8SIA4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST8SIA4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q21 Ensembl cytogenetic band: 5q21.1 HGNC cytogenetic band: 5q21

ST8SIA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST8SIA4 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M100171: view genomic region (about GC identifiers)

Start:	100,142,639 bp from pter	End:	100,238,987 bp from pter
Size:	96,349 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SIA8D_HUMAN, Q92187 (See protein sequence)

Recommended Name: CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

Size: 359 amino acids; 41295 Da

Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)

Secondary accessions: A8KA07 G3V104 Q8N1F4 Q92693

Alternative splicing: 2 isoforms: Q92187-1 Q92187-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ST8SIA4: NX_Q92187

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92187

4/8 DME Specific Peptides for ST8SIA4 (Q92187) (see all 8)

LYGFWPF

VRTAYPSL

VEWVNALILK

HAVRGYWLTNKV

ST8SIA4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_005659.1 NP_778222.1

ENSEMBL proteins:

ENSP00000231461 ENSP00000428914 ENSP00000428826

Reactome Protein details: Q92187
Human Recombinant Protein Products for ST8SIA4:

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	Novus Biologicals ST8SIA4 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ST8SIA4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	--
GO:0030173	integral to Golgi membrane	IEA	--

ST8SIA4 for ontologies About GeneDecksing

ST8SIA4 Antibody Products:

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	Uscn ELISAs and CLIAs for ST8SIA4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ST8SIA4 for domains About GeneDecksing

2 InterPro domains/families:

IPR001675 Glyco_trans_29

IPR012163 Sialyl_trans

Graphical View of Domain Structure for InterPro Entry Q92187

ProtoNet protein and cluster: Q92187

1 Blocks protein family: IPB001675 Glycosyl transferase

UniProtKB/Swiss-Prot: SIA8D_HUMAN, Q92187

Similarity: Belongs to the glycosyltransferase 29 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SIA8D_HUMAN, Q92187

Function: Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid

(PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural

cells

Enzyme Numbers (IUBMB): EC 2.4.99.-¹ EC 2.4.99²

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	IDA	10766765
GO:0033691	sialic acid binding	IC	10766765

ST8SIA4 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for ST8SIA4:

Decreased BPV1 E2 protein expr

Decreased cell number

Increased HPV18 LCR reporter a

5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for St8sia4):

behavior/neurological

cellular

growth/size

mortality/aging

nervous system

ST8SIA4 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for ST8SIA4: St8sia4^tm1Crem St8sia4^tm1.1Mifu

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ST8SIA4

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ST8SIA4 Browse MicroRNA Expression Plasmids
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		8/108 QIAGEN miScript miRNA Assays for microRNAs that regulate ST8SIA4 (see all 108):
		hsa-miR-3607-3p hsa-miR-607 hsa-miR-199a-3p hsa-miR-146a hsa-miR-30d hsa-miR-138-2* hsa-miR-519a hsa-miR-877*

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ST8SIA4 (see all 7) OriGene shRNA RFP: ST8SIA4 OriGene siRNA: ST8SIA4
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		Sirion Biotech Custom design and validation of potent shRNA sequences against ST8SIA4

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ST8SIA4
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ST8SIA4
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST8SIA4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

NCAM signaling for neurite out-growth

NCAM signaling for neurite out-growth

1.00

NCAM1 interactions

0.62

Axon guidance

Axon guidance

1.00

Developmental Biology

0.69

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for ST8SIA4

	Developmental Biology
	NCAM1 interactions
	NCAM signaling for neurite out-growth
	Axon guidance

UniProtKB/Swiss-Prot: SIA8D_HUMAN, Q92187

Pathway: Protein modification; protein glycosylation

ST8SIA4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ST8SIA4

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for ST8SIA4 (Q92187³ ENSP00000231461⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NCAM1	P13591³, ENSP00000318472⁴	I2D: score=1 STRING: ENSP00000318472

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001574	ganglioside biosynthetic process	IDA	10766765
GO:0006464	cellular protein modification process	TAS	7854457
GO:0006486	protein glycosylation	IDA	10766765
GO:0006491	N-glycan processing	IDA	10766765
GO:0007399	nervous system development	TAS	9054414

ST8SIA4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ST8SIA4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ST8SIA4
4 Novoseek chemical compound relationships for ST8SIA4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sialic acid	73.4	19	9774483 (3), 17176637 (2), 8567623 (2), 8805371 (1) (see all 5)
polysaccharide	46.4	3	9778105 (1), 19336400 (1), 17113863 (1)
valproic acid	34	3	15829700 (2), 15710344 (1)
galactose	19.8	1	8805371 (1)

Search CenterWatch for drugs/clinical trials and news about ST8SIA4 / SIA8D

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ST8SIA4 gene (2 alternative transcripts):

NM_005668.4 NM_175052.1

Unigene Cluster for ST8SIA4:

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

Hs.308628 [show with all ESTs]

Unigene Representative Sequence: NM_005668

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000231461(uc003knk.3) ENST00000451528(uc003knl.3) ENST00000507360

ENST00000523381

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ST8SIA4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST8SIA4
		8/108 QIAGEN miScript miRNA Assays for microRNAs that regulate ST8SIA4 (see all 108):
		hsa-miR-3607-3p hsa-miR-607 hsa-miR-199a-3p hsa-miR-146a hsa-miR-30d hsa-miR-138-2* hsa-miR-519a hsa-miR-877*

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ST8SIA4 (see all 7) OriGene shRNA RFP: ST8SIA4 OriGene siRNA: ST8SIA4
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST8SIA4

Additional cDNA sequence:

AK292872.1 BC027866.1 BC040671.2 BC053657.1 L41680.1

6 DOTS entries:

DT.403941 DT.97823239 DT.70104377 DT.40232274 DT.75137831 DT.91746301

24/79 AceView cDNA sequences (see all 79):

AI088644 AI298610 AA425652 AI684253 BM969177 BX479855 AA913822 BX106428

BC027866 BX099283 NM_175052 BM978519 BE219477 AI422986 NM_005668 AW137974

D62930 AI985772 AI139479 BX369253 BM921020 AW503641 BI858673 CB955960

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ST8SIA4 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6
SP1:							-								-
SP2:
SP3:							-

ECgene alternative splicing isoforms for ST8SIA4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ST8SIA4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTGAATGT

About this image

ST8SIA4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Zeugopod

Prechondrocytic Mesenchymal Cells

Bone, Cartilage

Neural Tube

Spinal Neural Tube Cells

Neural Ectoderm

Somite

Lumbar Vertebral Body

Somite

Spinal Cord

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

Definitive endoderm-like cells (Generation and expan...)

Endoderm progenitor-like cells (Generation and expan...)

Definitive endoderm-like cells (Generation of mesend...)

Definitive endoderm-like cells (A scalable, suspensi...)

Definitive Endoderm (Generation of beta c...)

HyStem+TGF?3+GDF5-induced SK11 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

See ST8SIA4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ST8SIA4

SOURCE GeneReport for Unigene cluster: Hs.308628

UniProtKB/Swiss-Prot: SIA8D_HUMAN, Q92187

Tissue specificity: Highly expressed in fetal brain, lung and kidney and in adult heart, spleen and thymus. Present to

a lesser extent in adult brain, placenta, lung, large and small intestine and peripheral blood leukocytes

SABiosciences Expression via Pathway-Focused PCR Array including ST8SIA4:

Glycosylation in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST8SIA4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST8SIA4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ST8SIA4 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	St8sia4^{1 , 5}	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more^{1, 5}	91.74(n)¹ 97.77(a)¹		1 (47.76 cM)⁵ 20452¹ NM_009183.2¹ NP_033209.1¹ 95587684⁵
chicken (Gallus gallus)	Aves	ST8SIA4¹	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more	85.61(n) 93.31(a)		374155 NM_204283.1 NP_989614.1
lizard (Anolis carolinensis)	Reptilia	A5I880_ANOCA⁶	Alpha 2,8-sialyltransferase ST8Sia IV Fragment (EC...	92(a)	1 ↔ 1	GL343193.1(578168-718173)
zebrafish (Danio rerio)	Actinopterygii	st8sia4¹	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more	64.78(n) 69.77(a)		553211 NM_001099416.1 NP_001092886.1

ENSEMBL Gene Tree for ST8SIA4 (if available)
TreeFam Gene Tree for ST8SIA4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ST8SIA4 gene

ST8SIA5² ST8SIA1² ST8SIA6² ST8SIA3² ST8SIA2²

6 SIMAP similar genes for ST8SIA4 using alignment to 2 protein entries: SIA8D_HUMAN (see all proteins):

ST8SIA2 ST8SIA3 ST8SIA5 ST8SIA1 ST8Sia VI ST8SIA6

ST8SIA4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188789551^1,2		--	100142176(+)	`TGAAAC/GCTCTT`	1	--	ds500¹		0	--	--	--	--
rs76388432^1,2	F	--	100142273(+)	`TTGAAA/TAAAAG`	1	--	ds500¹		1		WA	118
rs73163629^1,2	C	--	100142296(+)	`ATATAA/GATAAC`	1	--	ds500¹		2		WA	120
rs142853321^1,2		--	100142433(+)	`TTATAG/TAAAGC`	1	--	ds500¹		0	--	--	--	--
rs180871437^1,2		--	100142457(+)	`TTAAGC/TGTGTA`	1	--	ds500¹		0	--	--	--	--
rs150803217^1,2		--	100142514(+)	`TGGATC/TAAATA`	1	--	ds500¹		0	--	--	--	--
rs75400451^1,2	C	--	100142523(+)	`TAGCAC/GTCAAA`	1	--	ds500¹		0	--	--	--	--
rs17779305^1,2	C,F,H	--	100142626(+)	`AATGGA/GTATAA`	1	--	ds500¹		9		NA NS	1050
rs76787395^1,2		--	100142730(+)	`TTTTGA/GCATTG`	1	--	ut3¹		1		WA	118
rs185484426^1,2		--	100142804(+)	`AGGGGA/CGTGGA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ST8SIA4 (100142639 - 100238987 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ST8SIA4: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ST8SIA4 for disorders           About GeneDecksing

OMIM gene information: 602547    OMIM disorders: --

7 diseases for ST8SIA4:    About MalaCards

status epilepticus plague leukodystrophy schizophrenia

lung cancer neuroblastoma pancreatitis

2 Novoseek disease relationships for ST8SIA4 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
schizophrenia	7.73	1	16229822 (1)
tumors	0	4	11089916 (2), 15710344 (1), 10850459 (1)

Genetic Association Database (GAD): ST8SIA4
Human Genome Epidemiology (HuGE) Navigator: ST8SIA4 (7 documents)

Export disorders for ST8SIA4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ST8SIA4 gene, integrated from 9 sources (see all 65):
(articles sorted by number of sources associating them with ST8SIA4)

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Expression cloning of a human polysialyltransferase that forms the polysialylated neural cell adhesion molecule present in embryonic brain. (PubMed id 7624364)^{1, 2, 3} Nakayama J.... Fukuda M. (1995)
Unique disulfide bond structures found in ST8Sia IV polysialyltransferase are required for its activity. (PubMed id 11279095)^{1, 2, 9} Angata K.... Fukuda M. (2001)
Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia. (PubMed id 16229822)^{1, 4, 9} Arai M....Itokawa M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Differential and cooperative polysialylation of the neural cell adhesion molecule by two polysialyltransferases, PST and STX. (PubMed id 9774483)^{1, 9} Angata K....Fukuda M. (1998)
Polysialyltransferase-1 autopolysialylation is not requisite for polysialylation of neural cell adhesion molecule. (PubMed id 10660622)^{1, 9} Close B.E....Colley K.J. (2000)
Human STX polysialyltransferase forms the embryonic form of the neural cell adhesion molecule. Tissue-specific expression, neurite outgrowth, and chromosomal localization in comparison with another polysialyltransferase, PST. (PubMed id 9054414)^{1, 9} Angata K.... Fukuda M. (1997)
ST8Sia II and ST8Sia IV polysialyltransferases exhibit marked differences in utilizing various acceptors containing oligosialic acid and short polysialic acid. The basis for cooperative polysialylation by two enzymes. (PubMed id 12138100)^{1, 9} Angata K....Fukuda M. (2002)
Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha2,8-Sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III. (PubMed id 10766765)^{1, 9} Angata K.... Fukuda M. (2000)
Identification of sequences in the polysialyltransfer ases ST8Sia II and ST8Sia IV that are required for the protein-specific polysia lylation of the neural cell adhesion molecule, NCAM. (PubMed id 19336400)^{1, 9} Foley D.A....Colley K.J. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7903	HGNC: 10871	AceView: SIAT8D	Ensembl:ENSG00000113532	euGenes: HUgn7903
ECgene: ST8SIA4	H-InvDB: ST8SIA4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ST8SIA4	Pharmacogenomics, SNPs, Pathways
GGDB	http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST8SIA4
Functional Glycomics Gateway - GTase	http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_639

Intellectual Property for ST8SIA4 gene
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Patent Information for ST8SIA4 gene:
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