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ST8SIA4 Gene

protein-coding   GIFtS: 60
GCID: GC05M100171

ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase...

(Previous names: sialyltransferase 8 (alpha-2, 8-polysialytransferase) D)
(Previous symbol: SIAT8D)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 41 2     ST8Sia IV1
SIAT8D1 2 3     CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase2
PST2 3 5     ST8SIA-IV2
PST12 3 5     CMP-N-Acetylneuraminate-Poly-Alpha-2,8-Sialyl Transferase2
Sialyltransferase 8 (Alpha-2, 8-Polysialytransferase) D1 2     polysialyltransferase-12
Alpha-2,8-Sialyltransferase 8D2 3     Sialytransferase St8Sia IV2
Sialyltransferase 8D2 3     EC 2.4.99.-3
Sialyltransferase St8Sia IV2 3     Polysialyltransferase-13
SIAT8-D2 3     EC 2.4.998
ST8SiaIV2 3     

External Ids:    HGNC: 108711   Entrez Gene: 79032   Ensembl: ENSG000001135327   OMIM: 6025475   UniProtKB: Q921873   

Export aliases for ST8SIA4 gene to outside databases

Previous GC identifer: GC05M095326


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ST8SIA4 Gene:
The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the
synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1).
The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may
be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ST8SIA4 Gene:
ST8SIA4 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4) is a protein-coding gene. GO annotations related to this gene include alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity and sialic acid binding. An important paralog of this gene is ST8SIA5.

UniProtKB/Swiss-Prot: SIA8D_HUMAN, Q92187
Function: Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic
acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of
neural cells

Gene Wiki entry for ST8SIA4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ST8SIA4 gene promoter:
         Nkx3-1   POU2F1   AML1a   POU2F1a   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ST8SIA4 promoter sequence
   Search Chromatin IP Primers for ST8SIA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST8SIA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q21   Ensembl cytogenetic band:  5q21.1   HGNC cytogenetic band: 5q21

ST8SIA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST8SIA4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M100171:  view genomic region     (about GC identifiers)

Start:
100,142,639 bp from pter      End:
100,238,987 bp from pter
Size:
96,349 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SIA8D_HUMAN, Q92187 (See protein sequence)
Recommended Name: CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase  
Size: 359 amino acids; 41295 Da
Secondary accessions: A8KA07 G3V104 Q8N1F4 Q92693
Alternative splicing: 2 isoforms:  Q92187-1   Q92187-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ST8SIA4: NX_Q92187

Explore proteomics data for ST8SIA4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn50, Asn74, Asn119, Asn204, Asn219
  • Selected DME Specific Peptides for ST8SIA4 (Q92187) (see all 8)
     LYGFWPF  VRTAYPSL  VEWVNALILK  HAVRGYWLTNKV 


    See ST8SIA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005659.1  NP_778222.1  

    ENSEMBL proteins: 
     ENSP00000231461   ENSP00000428914   ENSP00000428826  
    Reactome Protein details: Q92187

    ST8SIA4 Human Recombinant Protein Products:

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    antibodies-online peptides for ST8SIA4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ST3G: Sialyltransferases

    2 InterPro protein domains:
     IPR001675 Glyco_trans_29
     IPR012163 Sialyl_trans

    Graphical View of Domain Structure for InterPro Entry Q92187

    ProtoNet protein and cluster: Q92187

    1 Blocks protein domain: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIA8D_HUMAN, Q92187
    Similarity: Belongs to the glycosyltransferase 29 family


    Find genes that share domains with ST8SIA4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIA8D_HUMAN, Q92187
    Function: Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic
    acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of
    neural cells

         Enzyme Numbers (IUBMB): EC 2.4.99.-1 EC 2.4.992

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003828alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA10766765
    GO:0008373sialyltransferase activity ----
    GO:0033691sialic acid binding IC10766765
         
    Find genes that share ontologies with ST8SIA4           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ST8SIA4:
     Decreased BPV1 E2 protein expr  Decreased cell number  Increased HPV18 LCR reporter a 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for St8sia4):
     behavior/neurological  cellular  growth/size/body  mortality/aging  nervous system 

    Find genes that share phenotypes with ST8SIA4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ST8SIA4: St8sia4tm1Crem St8sia4tm1.1Mifu

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ST8SIA4
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    miRNA
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    miRTarBase miRNAs that target ST8SIA4:
    hsa-mir-335-5p (MIRT017872)

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    Selected qRT-PCR Assays for microRNAs that regulate ST8SIA4 (see all 108):
    hsa-miR-3607-3p hsa-miR-607 hsa-miR-199a-3p hsa-miR-146a hsa-miR-30d hsa-miR-138-2* hsa-miR-519a hsa-miR-877*
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIA8D_HUMAN, Q92187: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    mitochondrion2
    cytosol1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0030173integral component of Golgi membrane IEA--

    Find genes that share ontologies with ST8SIA4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ST8SIA4 About    
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    2NCAM signaling for neurite out-growth
    NCAM1 interactions0.59
    NCAM signaling for neurite out-growth0.59


    Find genes that share SuperPaths with ST8SIA4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for ST8SIA4
        NCAM1 interactions
    Sialic acid metabolism


    UniProtKB/Swiss-Prot: SIA8D_HUMAN, Q92187
    Pathway: Protein modification; protein glycosylation

        Pathway & Disease-focused RT2 Profiler PCR Array including ST8SIA4: 

              Glycosylation in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ST8SIA4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ST8SIA4 (Q921873 ENSP000002314614) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCAM1P135913, ENSP000003184724I2D: score=1 STRING: ENSP00000318472
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001574ganglioside biosynthetic process IDA10766765
    GO:0006464cellular protein modification process TAS7854457
    GO:0006486protein glycosylation IDA10766765
    GO:0006491N-glycan processing IDA10766765
    GO:0007399nervous system development TAS9054414

    Find genes that share ontologies with ST8SIA4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for ST8SIA4 (SIA8D)

    4 Novoseek inferred chemical compound relationships for ST8SIA4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sialic acid 73.4 19 9774483 (3), 17176637 (2), 8567623 (2), 8805371 (1) (see all 5)
    polysaccharide 46.4 3 9778105 (1), 19336400 (1), 17113863 (1)
    valproic acid 34 3 15829700 (2), 15710344 (1)
    galactose 19.8 1 8805371 (1)



    Find genes that share compounds with ST8SIA4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ST8SIA4 gene (2 alternative transcripts): 
    NM_005668.5  NM_175052.2  

    Unigene Cluster for ST8SIA4:

    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
    Hs.308628  [show with all ESTs]
    Unigene Representative Sequence: NM_005668
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000231461(uc003knk.3) ENST00000451528(uc003knl.3) ENST00000507360
    ENST00000523381
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ST8SIA4 (see all 108):
    hsa-miR-3607-3p hsa-miR-607 hsa-miR-199a-3p hsa-miR-146a hsa-miR-30d hsa-miR-138-2* hsa-miR-519a hsa-miR-877*
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      QuantiTect SYBR Green Assays in human, mouse, rat ST8SIA4
      QuantiFast Probe-based Assays in human, mouse, rat ST8SIA4

    Additional mRNA sequence: 

    AK292872.1 BC027866.1 BC040671.2 BC053657.1 L41680.1 

    6 DOTS entries:

    DT.403941  DT.97823239  DT.70104377  DT.40232274  DT.75137831  DT.91746301 

    Selected AceView cDNA sequences (see all 79):

    AA425652 AW137974 BE219477 AA913822 BX106428 BC027866 BM969177 NM_175052 
    NM_005668 AI088644 BX099283 BM978519 AI298610 BX479855 AI684253 AI422986 
    AI962652 AA425207 BX089871 AA552969 BI768383 BI907591 AA026184 BX369253 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ST8SIA4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6
    SP1:                    -                       -               
    SP2:                                                            
    SP3:                    -                                       


    ECgene alternative splicing isoforms for ST8SIA4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ST8SIA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTGAATGT
    ST8SIA4 Expression
    About this image


    ST8SIA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Prechondrocytic Mesenchymal Cells Zeugopod
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Prechondrocytic Mesenchymal Cells Zeugopod
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Definitive endoderm-like cells
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             hIPS1
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    ST8SIA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ST8SIA4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.308628

    UniProtKB/Swiss-Prot: SIA8D_HUMAN, Q92187
    Tissue specificity: Highly expressed in fetal brain, lung and kidney and in adult heart, spleen and thymus.
    Present to a lesser extent in adult brain, placenta, lung, large and small intestine and peripheral blood
    leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including ST8SIA4: 
              Glycosylation in human mouse rat

    Primer
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    QuantiTect SYBR Green Assays in human, mouse, rat ST8SIA4
    QuantiFast Probe-based Assays in human, mouse, rat ST8SIA4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST8SIA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ST8SIA4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St8sia41 , 5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more1, 5 91.74(n)1
    97.77(a)1
      1 (47.76 cM)5
    204521  NM_009183.21  NP_033209.11 
     955876845 
    chicken
    (Gallus gallus)
    Aves ST8SIA41 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more 85.61(n)
    93.31(a)
      374155  NM_204283.1  NP_989614.1 
    lizard
    (Anolis carolinensis)
    Reptilia ST8SIA46
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltra...
    92(a)
    1 ↔ 1
    GL343193.1(578168-718678)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia st8sia41 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more 79.48(n)
    87.74(a)
      100036733  NM_001097278.1  NP_001090747.1 
    zebrafish
    (Danio rerio)
    Actinopterygii st8sia41 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more 64.97(n)
    70.06(a)
      553211  NM_001099416.1  NP_001092886.1 


    ENSEMBL Gene Tree for ST8SIA4 (if available)
    TreeFam Gene Tree for ST8SIA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ST8SIA4 gene
    ST8SIA52  ST8SIA12  ST8SIA62  ST8SIA32  ST8SIA22  
    6 SIMAP similar genes for ST8SIA4 using alignment to 2 protein entries:     SIA8D_HUMAN (see all proteins):
    ST8SIA2    ST8SIA3    ST8SIA5    ST8SIA1    ST8Sia VI    ST8SIA6

    Find genes that share paralogs with ST8SIA4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ST8SIA4 (see all 1556)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361694
    A colorectal cancer sample4--see VAR_0361692 E G mis40--------
    rs1887895511,2
    --100142176(+) TGAAAC/GCTCTT 1 -- ds50010--------
    rs763884321,2
    F--100142273(+) TTGAAA/TAAAAG 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs731636291,2
    C,F--100142296(+) ATATAA/GATAAC 1 -- ds50012Minor allele frequency- G:0.03WA 120
    rs1428533211,2
    --100142433(+) TTATAG/TAAAGC 1 -- ds50010--------
    rs1808714371,2
    --100142457(+) TTAAGC/TGTGTA 1 -- ds50010--------
    rs1508032171,2
    --100142514(+) TGGATC/TAAATA 1 -- ds50010--------
    rs754004511,2
    C--100142523(+) TAGCAC/GTCAAA 1 -- ds50010--------
    rs177793051,2
    C,F,H--100142626(+) AATGGA/GTATAA 1 -- ds50019Minor allele frequency- G:0.02NA NS 1050
    rs767873951,2
    F--100142730(+) TTTTGA/GCATTG 1 -- ut311Minor allele frequency- G:0.01WA 118

    HapMap Linkage Disequilibrium report for ST8SIA4 (100142639 - 100238987 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ST8SIA4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv882471CNV Loss21882294
    dgv6238n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ST8SIA4
    DNA2.0 Custom Variant and Variant Library Synthesis for ST8SIA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602547    OMIM disorders: --


    Find genes that share disorders with ST8SIA4           About GenesLikeMe

    2 Novoseek inferred disease relationships for ST8SIA4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 7.73 1 16229822 (1)
    tumors 0 4 11089916 (2), 15710344 (1), 10850459 (1)

    Genetic Association Database (GAD): ST8SIA4
    Human Genome Epidemiology (HuGE) Navigator: ST8SIA4 (7 documents)

    Export disorders for ST8SIA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ST8SIA4 gene, integrated from 10 sources (see all 75):
    (articles sorted by number of sources associating them with ST8SIA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression cloning of a human polysialyltransferase that forms the polysialylated neural cell adhesion molecule present in embryonic brain. (PubMed id 7624364)1, 2, 3 Nakayama J.... Fukuda M. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    2. Unique disulfide bond structures found in ST8Sia IV polysialyltransferase are required for its activity. (PubMed id 11279095)1, 2, 9 Angata K.... Fukuda M. (J. Biol. Chem. 2001)
    3. Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia. (PubMed id 16229822)1, 4, 9 Arai M....Itokawa M. (Biol. Psychiatry 2006)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations. (PubMed id 19578876)1, 4 Johnson M.P....Moses E.K. (Hum. Genet. 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Differential and cooperative polysialylation of the neural cell adhesion molecule by two polysialyltransferases, PST and STX. (PubMed id 9774483)1, 9 Angata K....Fukuda M. (J. Biol. Chem. 1998)
    9. Polysialyltransferase-1 autopolysialylation is not requisite for polysialylation of neural cell adhesion molecule. (PubMed id 10660622)1, 9 Close B.E....Colley K.J. (J. Biol. Chem. 2000)
    10. Human STX polysialyltransferase forms the embryonic form of the neural cell adhesion molecule. Tissue-specific expression, neurite outgrowth, and chromosomal localization in comparison with another polysialyltransferase, PST. (PubMed id 9054414)1, 9 Angata K.... Fukuda M. (J. Biol. Chem. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7903 HGNC: 10871 AceView: SIAT8D Ensembl:ENSG00000113532 euGenes: HUgn7903
    ECgene: ST8SIA4 H-InvDB: ST8SIA4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ST8SIA4 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST8SIA4
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_639

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ST8SIA4 gene:
    Search GeneIP for patents involving ST8SIA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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