Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ST8SIA3 Gene

protein-coding   GIFtS: 52
GCID: GC18P055019

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase...

(Previous name: sialyltransferase 8C (alpha2,3Galbeta1,4GlcNAcalpha 2,8-sialyltransferase)...)
(Previous symbol: SIAT8C)
 Explore 1 disease affiliated with
ST8SIA3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ST8SIA3    

Aliases
for ST8SIA3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 31 2 3     SIAT8-C2 3
SIAT8C1 2 3     ST8SiaIII2 3
Sialyltransferase 8C (Alpha2,3Galbeta1,4GlcNAcalpha 2,8-Sialyltransferase)1 2     Sia-Alpha-2,3-Gal-Beta-1,4-GlcNAc-R:Alpha 2,8-Sialyltransferase2
Alpha-2,8-Sialyltransferase 8C2 3     Sialytransferase St8Sia III2
Alpha-2,8-Sialyltransferase III2 3     EC 2.4.99.-3
Sialyltransferase St8Sia III2 3     Sialyltransferase 8C3

External Ids:    HGNC: 142691   Entrez Gene: 510462   Ensembl: ENSG000001775117   OMIM: 6094785   UniProtKB: O431733   

Export aliases for ST8SIA3 gene to outside databases

Previous GC identifers: GC18P053170 GC18P051730


Summaries
for ST8SIA3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ST8SIA3:
ST8SIA3 belongs to a family of sialyltransferases that form sialyl-alpha-2,8-sialyl-R linkages at the nonreducing
termini of glycoconjugates (Lee et al., 1998 (PubMed 9826427)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: SIA8C_HUMAN, O43173
Function: May transfer sialic acid through alpha-2,8-linkages to alpha-2,3-linked and alpha-2,8-linked sialic acid of
N-linked oligosaccharides of glycoproteins and glycolipids. It can form polysialic acid in vitro directly on
alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid




Genomic Views
for ST8SIA3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_025028.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ST8SIA3 gene promoter:
         HOXA9B   HOXA9   p53   AP-1   AREB6   MEF-2A   FOXJ2   aMEF-2   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ST8SIA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ST8SIA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST8SIA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.31   Ensembl cytogenetic band:  18q21.31   HGNC cytogenetic band: 18q21.31

ST8SIA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST8SIA3 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P055019:  view genomic region     (about GC identifiers)

Start:
 55,018,044 bp from pter      End:
 55,038,962 bp from pter
Size:
 20,919 bases      Orientation:
 plus strand

Proteins
for ST8SIA3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SIA8C_HUMAN, O43173 (See protein sequence)
Recommended Name: Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase  
Size: 380 amino acids; 43970 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
Secondary accessions: A8K0F2 Q6B085 Q9NS41

Explore the universe of human proteins at neXtProt for ST8SIA3: NX_O43173

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43173

    • ST8SIA3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056963.2  
    ENSEMBL proteins: 
     ENSP00000320431   ENSP00000467752  
    Reactome Protein details: O43173
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: ST8SIA3
    OriGene Custom Protein Services for ST8SIA3 
    GenScript Custom Purified and Recombinant Proteins Services for ST8SIA3
    Novus Biologicals ST8SIA3 Protein
    Novus Biologicals ST8SIA3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ST8SIA3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0030173integral to Golgi membrane IEA--


    ST8SIA3 for ontologies           About GeneDecksing



    ST8SIA3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ST8SIA3 
    GenScript Custom Superior Antibodies Services for ST8SIA3
    Search for Antibodies for ST8SIA3 at Abcam  
    Uscn Antibodies for ST8SIA3
    ThermoFisher Antibodies for ST8SIA3

    Assay Products for ST8SIA3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ST8SIA3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ST8SIA3

    Protein Domains /
    Families
    for ST8SIA3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ST8SIA3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001675 Glyco_trans_29
     IPR012163 Sialyl_trans

    Graphical View of Domain Structure for InterPro Entry O43173

    ProtoNet protein and cluster: O43173

    1 Blocks protein family: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIA8C_HUMAN, O43173
    Similarity: Belongs to the glycosyltransferase 29 family


    Function
    for ST8SIA3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SIA8C_HUMAN, O43173
    Function: May transfer sialic acid through alpha-2,8-linkages to alpha-2,3-linked and alpha-2,8-linked sialic acid of
    N-linked oligosaccharides of glycoproteins and glycolipids. It can form polysialic acid in vitro directly on
    alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid

    Enzyme Number (IUBMB): EC 2.4.99.-1

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ST8SIA3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST8SIA3
    8/120 QIAGEN miScript miRNA Assays for microRNAs that regulate ST8SIA3 (see all 120):
    hsa-miR-579 hsa-miR-26a-2* hsa-miR-520e hsa-miR-106a hsa-miR-15a hsa-miR-4272 hsa-miR-93 hsa-miR-642b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ST8SIA3 (see all 7)
    OriGene shRNA RFP: ST8SIA3
    OriGene siRNA: ST8SIA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST8SIA3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ST8SIA3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ST8SIA3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ST8SIA3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ST8SIA3 (NM_015879)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST8SIA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST8SIA3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ST8SIA3
    Search LifeMap BioReagents cell lines for ST8SIA3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST8SIA3

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003828alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA9826427
    GO:0008373sialyltransferase activity ----
    GO:0033691sialic acid binding IC9826427


    ST8SIA3 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ST8SIA3:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 


    Pathways & Interactions
    for ST8SIA3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1N-glycan antennae elongation in the medial/trans-Golgi
    		N-glycan antennae elongation in the medial/trans-Golgi1.00
    		Transport to the Golgi and subsequent modification0.56
    		N-Glycan antennae elongation0.75
    2Asparagine N-linked glycosylation
    		Asparagine N-linked glycosylation1.00
    		Metabolism of proteins0.15
    		Post-translational protein modification0.44

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for ST8SIA3 (see all 6)
        N-glycan antennae elongation in the medial/trans-Golgi
    Transport to the Golgi and subsequent modification
    Asparagine N-linked glycosylation
    N-Glycan antennae elongation
    Metabolism of proteins


    UniProtKB/Swiss-Prot: SIA8C_HUMAN, O43173
    Pathway: Protein modification; protein glycosylation


    ST8SIA3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ST8SIA3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ST8SIA3 (O431733 ENSP000003204314) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCAM1P135913, ENSP000003184724I2D: score=1 STRING: ENSP00000318472
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001574ganglioside biosynthetic process IDA10766765
    GO:0006486protein glycosylation IDA10766765
    GO:0006491N-glycan processing IDA10766765
    GO:0006688glycosphingolipid biosynthetic process TAS9073076
    GO:0009100glycoprotein metabolic process IDA9826427


    ST8SIA3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ST8SIA3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ST8SIA3
    Search CenterWatch for drugs/clinical trials and news about ST8SIA3 / SIA8C 

    Transcripts
    for ST8SIA3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ST8SIA3 gene: 
    NM_015879.2  

    Unigene Cluster for ST8SIA3:

    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
    Hs.23172  [show with all ESTs]
    Unigene Representative Sequence: NM_015879
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324000(uc002lgn.3) ENST00000586360 ENST00000590600

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ST8SIA3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST8SIA3
    8/120 QIAGEN miScript miRNA Assays for microRNAs that regulate ST8SIA3 (see all 120):
    hsa-miR-579 hsa-miR-26a-2* hsa-miR-520e hsa-miR-106a hsa-miR-15a hsa-miR-4272 hsa-miR-93 hsa-miR-642b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ST8SIA3 (see all 7)
    OriGene shRNA RFP: ST8SIA3
    OriGene siRNA: ST8SIA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST8SIA3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ST8SIA3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ST8SIA3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ST8SIA3 (NM_015879)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST8SIA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST8SIA3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ST8SIA3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ST8SIA3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ST8SIA3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST8SIA3

    Additional cDNA sequence: 

    AB208996.1 AF003092.2 AF004668.2 AK054939.1 AK123291.1 AK289517.1 AK313047.1 BC074909.2 

    3 DOTS entries:

    DT.407021  DT.75121663  DT.91693971 

    14 AceView cDNA sequences:

    AF003092 BP350109 BC074909 AA074184 NM_015879 AF004668 AA062572 CD246043 
    AA063150 BX370279 BF433154 AU253291 BX096550 H96110 

    GeneLoc Exon Structure


    Expression
    for ST8SIA3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ST8SIA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ST8SIA3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    Gut TubeForegutForegut Endoderm CellsEndoderm
    BoneMaxillary ProcessBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ST8SIA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ST8SIA3

    SOURCE GeneReport for Unigene cluster: Hs.23172

    UniProtKB/Swiss-Prot: SIA8C_HUMAN, O43173
    Tissue specificity: Expressed in fetal and adult brain and fetal liver

        SABiosciences Expression via Pathway-Focused PCR Array including ST8SIA3: 
              Glycosylation in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ST8SIA3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ST8SIA3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ST8SIA3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST8SIA3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST8SIA3

    Orthologs
    for ST8SIA3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ST8SIA3 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ST8SIA31 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 less 84(n)
    95.2(a)    		   414796  NM_001001746.1  NP_001001746.1 
    lizard
    (Anolis carolinensis)    		 Reptilia A5I879_ANOCA6
    		 Alpha 2,8-sialyltransferase ST8Sia III Fragment (E...
    		 90(a)
    		 1 ↔ 1
    		 GL343213.1(1964265-1987253)
    zebrafish
    (Danio rerio)    		 Actinopterygii st8sia31 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 less 72.1(n)
    80.21(a)    		   553510  NM_001113432.1  NP_001106903.1 


    ENSEMBL Gene Tree for ST8SIA3 (if available)
    TreeFam Gene Tree for ST8SIA3 (if available) 

    Paralogs
    for ST8SIA3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ST8SIA3 gene
    ST8SIA52  ST8SIA12  ST8SIA62  ST8SIA22  ST8SIA42  
    6 SIMAP similar genes for ST8SIA3 using alignment to 2 protein entries:     SIA8C_HUMAN (see all proteins):
    ST8SIA2    ST8SIA4    SIA8F    ST8SIA6    ST8Sia VI    ST8SIA1

    ST8SIA3 for paralogs           About GeneDecksing



    Genomic Variants
    for ST8SIA3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/326 NCBI SNPs in ST8SIA3 are shown (see all 326)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs5948861,2
    		F,--55017756(-) CAAACT/CGAACT 1 -- us2k11Minor allele frequency- C:0.08WA 118
    rs1392781701,2
    		--55017759(+) TCAGTC/TTGTAG 1 -- us2k10--------
    rs1417263261,2
    		--55017783(+) CCTCTA/GTACTG 1 -- us2k10--------
    rs1832258071,2
    		--55017911(+) GCTTTC/TGAAGT 1 -- us2k10--------
    rs1878056231,2
    		--55017948(+) AGGTGC/TAACAC 1 -- us2k10--------
    rs1927640781,2
    		--55017983(+) ATGTTG/TCCTGA 1 -- us2k10--------
    rs1824407261,2
    		--55018069(+) TTTTAC/TACCTT 1 -- us2k10--------
    rs1137312211,2
    		C,--55018111(+) TTAAAA/GAAATA 1 -- us2k12Minor allele frequency- G:0.06NA 122
    rs1878989601,2
    		--55018280(+) TTGTCA/GCTGGA 1 -- us2k10--------
    rs1924134761,2
    		--55018428(+) TCTGCC/TGAAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ST8SIA3 (55018044 - 55038962 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ST8SIA3: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ST8SIA3
    DNA2.0 Custom Variant and Variant Library Synthesis for ST8SIA3

    Disorders / Diseases
    for ST8SIA3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ST8SIA3 for disorders           About GeneDecksing

    OMIM gene information: 609478    OMIM disorders: --

    1 disease for ST8SIA3:    About MalaCards
    glioblastoma

    Human Genome Epidemiology (HuGE) Navigator: ST8SIA3 (1 document)

    Export disorders for ST8SIA3 gene to outside databases

    Publications
    for ST8SIA3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ST8SIA3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ST8SIA3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha2,8-Sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III. (PubMed id 10766765)1, 2, 9 Angata K.... Fukuda M. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Cloning and expression of cDNA for a human Sia alpha 2,3Gal beta 1,4GlcNA:alpha 2,8-sialyltransferase (hST8Sia III). (PubMed id 9826427)1, 2 Lee Y.-C.... Do S.-I. (1998)
    5. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1 Flachsbart F....Nebel A. (2010)
    6. Molecular mechanisms involved in transcriptional activation of the human Sia-alpha2,3-Gal-beta1,4-GlcNAc-R:alpha2,8-sialyltransferase (hST8Sia III) gene induced by KCl in human glioblastoma cells. (PubMed id 16643848)1 Kim S.J....Kim C.H. (2006)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Cloning of the cDNA coding for rat brain CMP-NeuAc:GD3 alpha2-8 sialyltransferase. (PubMed id 9073076)1 Zeng G....Yu R.K. (1997)
    9. Molecular dissection of the ST8Sia IV polysialyltransferase. Distinct domains are required for neural cell adhesion molecule recognition and polysialylation. (PubMed id 15067013)9 Angata K....Fukuda M. (2004)

    External Searches for ST8SIA3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ST8SIA3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51046 HGNC: 14269 AceView: SIAT8C Ensembl:ENSG00000177511 euGenes: HUgn51046
    ECgene: ST8SIA3 H-InvDB: ST8SIA3

    Other Databases showing ST8SIA3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ST8SIA3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ST8SIA3 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST8SIA3
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_638

    Intellectual Property
    for ST8SIA3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ST8SIA3 gene:
    Search GeneIP for patents involving ST8SIA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ST8SIA3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for ST8SIA3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ST8SIA3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ST8SIA3  
     OriGene Protein Over-expression Lysate for ST8SIA3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ST8SIA3   OriGene 3'-UTR Clone for ST8SIA3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ST8SIA3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ST8SIA3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ST8SIA3   OriGene Custom Protein Services for ST8SIA3  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ST8SIA3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ST8SIA3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST8SIA3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST8SIA3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST8SIA3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ST8SIA3
     GenScript Custom Purified and Recombinant Proteins Services for ST8SIA3 GenScript cDNA clones with any tag delivered in your preferred vector for ST8SIA3
     GenScript Custom Assay Services for ST8SIA3 GenScript Custom Superior Antibodies Services for ST8SIA3
     GenScript Custom overexpressing Cell Line Services for ST8SIA3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ST8SIA3 promoter
     Search Chromatin IP Primers for ST8SIA3
     RT2 qPCR Primer Assay in human, mouse, rat ST8SIA3
     Search GNC Networks for ST8SIA3
     SABiosciences PCR Arrays including human, mouse, rat ST8SIA3
     Search Tocris compounds for ST8SIA3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ST8SIA3 proteins
     ST8SIA3 lysates
     Search for Antibodies for ST8SIA3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ST8SIA3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ST8SIA3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ST8SIA3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST8SIA3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ST8SIA3
     SwitchGear Promoter luciferase reporter plasmids for ST8SIA3
     ThermoFisher Antibodies for ST8SIA3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST8SIA3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ST8SIA3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4