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Aliases for ST8SIA3 Gene

Aliases for ST8SIA3 Gene

  • ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 3 2 3 4
  • Sialyltransferase 8C (Alpha2,3Galbeta1,4GlcNAcalpha 2,8-Sialyltransferase) 2 3
  • Alpha-2,8-Sialyltransferase III 3 4
  • Alpha-2,8-Sialyltransferase 8C 3 4
  • Sialyltransferase St8Sia III 3 4
  • ST8SiaIII 3 4
  • SIAT8-C 3 4
  • SIAT8C 3 4
  • Sia-Alpha-2,3-Gal-Beta-1,4-GlcNAc-R:Alpha 2,8-Sialyltransferase 3
  • Sialytransferase St8Sia III 3
  • Sialyltransferase 8C 4
  • EC 2.4.99.- 4
  • ST8Sia III 2

External Ids for ST8SIA3 Gene

Previous Symbols for ST8SIA3 Gene

  • SIAT8C

Summaries for ST8SIA3 Gene

Entrez Gene Summary for ST8SIA3 Gene

  • ST8SIA3 belongs to a family of sialyltransferases that form sialyl-alpha-2,8-sialyl-R linkages at the nonreducing termini of glycoconjugates (Lee et al., 1998 [PubMed 9826427]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ST8SIA3 Gene

ST8SIA3 (ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 3) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include sialic acid binding and alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. An important paralog of this gene is ST8SIA1.

UniProtKB/Swiss-Prot for ST8SIA3 Gene

  • May transfer sialic acid through alpha-2,8-linkages to alpha-2,3-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST8SIA3 Gene

Genomics for ST8SIA3 Gene

Genomic Location for ST8SIA3 Gene

Start:
57,350,813 bp from pter
End:
57,371,731 bp from pter
Size:
20,919 bases
Orientation:
Plus strand

Genomic View for ST8SIA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ST8SIA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST8SIA3 Gene

Regulatory Elements for ST8SIA3 Gene

Proteins for ST8SIA3 Gene

  • Protein details for ST8SIA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43173-SIA8C_HUMAN
    Recommended name:
    Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase
    Protein Accession:
    O43173
    Secondary Accessions:
    • A8K0F2
    • Q6B085
    • Q9NS41

    Protein attributes for ST8SIA3 Gene

    Size:
    380 amino acids
    Molecular mass:
    43970 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST8SIA3 Gene

Proteomics data for ST8SIA3 Gene at MOPED

Post-translational modifications for ST8SIA3 Gene

  • Glycosylation at Asn93, Asn113, and Asn206

Other Protein References for ST8SIA3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ST8SIA3 Gene

Domains for ST8SIA3 Gene

Gene Families for ST8SIA3 Gene

HGNC:
  • ST3G :Sialyltransferases

Protein Domains for ST8SIA3 Gene

UniProtKB/Swiss-Prot:

SIA8C_HUMAN
Family:
  • Belongs to the glycosyltransferase 29 family.:
    • O43173
genes like me logo Genes that share domains with ST8SIA3: view

Function for ST8SIA3 Gene

Molecular function for ST8SIA3 Gene

UniProtKB/Swiss-Prot Function: May transfer sialic acid through alpha-2,8-linkages to alpha-2,3-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid.

Enzyme Numbers (IUBMB) for ST8SIA3 Gene

Gene Ontology (GO) - Molecular Function for ST8SIA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA 10766765
GO:0008373 sialyltransferase activity --
GO:0033691 sialic acid binding IC 9826427
genes like me logo Genes that share ontologies with ST8SIA3: view

Phenotypes for ST8SIA3 Gene

GenomeRNAi human phenotypes for ST8SIA3:
genes like me logo Genes that share phenotypes with ST8SIA3: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ST8SIA3 Gene

Localization for ST8SIA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST8SIA3 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST8SIA3 Gene COMPARTMENTS Subcellular localization image for ST8SIA3 gene
Compartment Confidence
golgi apparatus 5

Gene Ontology (GO) - Cellular Components for ST8SIA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0030173 integral component of Golgi membrane IEA --
genes like me logo Genes that share ontologies with ST8SIA3: view

Pathways for ST8SIA3 Gene

genes like me logo Genes that share pathways with ST8SIA3: view

UniProtKB/Swiss-Prot O43173-SIA8C_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for ST8SIA3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000320431%0d%0a9606.ENSP00000358565%0d%0a
Selected Interacting proteins: O43173-SIA8C_HUMAN ENSP00000320431 for ST8SIA3 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for ST8SIA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001574 ganglioside biosynthetic process IDA 10766765
GO:0006486 protein glycosylation IDA 10766765
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006491 N-glycan processing IDA 10766765
GO:0006688 glycosphingolipid biosynthetic process TAS 9073076
genes like me logo Genes that share ontologies with ST8SIA3: view

Transcripts for ST8SIA3 Gene

mRNA/cDNA for ST8SIA3 Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ST8SIA3 Gene

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ST8SIA3 Gene

No ASD Table

Relevant External Links for ST8SIA3 Gene

GeneLoc Exon Structure for
ST8SIA3
ECgene alternative splicing isoforms for
ST8SIA3

Expression for ST8SIA3 Gene

mRNA expression in normal human tissues for ST8SIA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST8SIA3 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (7.3), Brain - Caudate (basal ganglia) (6.7), Brain - Nucleus accumbens (basal ganglia) (6.7), Brain - Frontal Cortex (BA9) (4.8), Brain - Anterior cingulate cortex (BA24) (4.2), and Brain - Cortex (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ST8SIA3 Gene

SOURCE GeneReport for Unigene cluster for ST8SIA3 Gene Hs.23172

mRNA Expression by UniProt/SwissProt for ST8SIA3 Gene

O43173-SIA8C_HUMAN
Tissue specificity: Expressed in fetal and adult brain and fetal liver.
genes like me logo Genes that share expressions with ST8SIA3: view

Orthologs for ST8SIA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST8SIA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST8SIA3 36
  • 99.56 (n)
  • 98.95 (a)
ST8SIA3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ST8SIA3 36
  • 92.35 (n)
  • 92.61 (a)
ST8SIA3 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ST8SIA3 36
  • 96.14 (n)
  • 97.63 (a)
ST8SIA3 37
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St8sia3 36
  • 92.28 (n)
  • 97.89 (a)
St8sia3 16
St8sia3 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ST8SIA3 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ST8SIA3 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia St8sia3 36
  • 91.67 (n)
  • 96.84 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 93 (a)
OneToMany
SIAT8C 37
  • 95 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ST8SIA3 37
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st8sia3 36
  • 78.25 (n)
  • 90.26 (a)
zebrafish
(Danio rerio)
Actinopterygii st8sia3 36
  • 72.1 (n)
  • 80.21 (a)
st8sia3 37
  • 80 (a)
OneToOne
Species with no ortholog for ST8SIA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST8SIA3 Gene

ENSEMBL:
Gene Tree for ST8SIA3 (if available)
TreeFam:
Gene Tree for ST8SIA3 (if available)

Paralogs for ST8SIA3 Gene

Paralogs for ST8SIA3 Gene

Selected SIMAP similar genes for ST8SIA3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ST8SIA3: view

Variants for ST8SIA3 Gene

Sequence variations from dbSNP and Humsavar for ST8SIA3 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs486303 -- 57,368,699(-) CAGTG(C/T)TGGCT utr-variant-3-prime
rs496544 -- 57,363,249(-) CAGAG(C/G)GTCTA utr-variant-3-prime
rs542425 -- 57,360,775(-) AGGGA(A/G)GGAGT utr-variant-3-prime
rs547938 -- 57,361,411(-) GAAAA(C/T)GATCG utr-variant-3-prime
rs564748 -- 57,358,084(-) ATTCT(A/C)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST8SIA3 Gene

Variant ID Type Subtype PubMed ID
esv2677142 CNV Deletion 23128226

Relevant External Links for ST8SIA3 Gene

HapMap Linkage Disequilibrium report
ST8SIA3

Disorders for ST8SIA3 Gene

Relevant External Links for ST8SIA3

Genetic Association Database (GAD)
ST8SIA3
Human Genome Epidemiology (HuGE) Navigator
ST8SIA3
genes like me logo Genes that share disorders with ST8SIA3: view

No data available for UniProtKB/Swiss-Prot for ST8SIA3 Gene

Publications for ST8SIA3 Gene

  1. Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha2,8-Sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III. (PMID: 10766765) Angata K. … Fukuda M. (J. Biol. Chem. 2000) 3 4 23
  2. Cloning and expression of cDNA for a human Sia alpha 2,3Gal beta 1,4GlcNA:alpha 2,8-sialyltransferase (hST8Sia III). (PMID: 9826427) Lee Y.-C. … Do S.-I. (Arch. Biochem. Biophys. 1998) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 49

Products for ST8SIA3 Gene

  • antibodies-online proteins for ST8SIA3
  • antibodies-online antibodies for ST8SIA3
  • antibodies-online kits for ST8SIA3

Sources for ST8SIA3 Gene

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