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ST8SIA3 Gene

protein-coding   GIFtS: 51
GCID: GC18P055019

ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase...

(Previous name: sialyltransferase 8C (alpha2,3Galbeta1,4GlcNAcalpha 2,8-sialyltransferase))
(Previous symbol: SIAT8C)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 31 2 3     ST8SiaIII2 3
SIAT8C1 2 3     ST8Sia III1
Sialyltransferase 8C (Alpha2,3Galbeta1,4GlcNAcalpha 2,8-Sialyltransferase)1 2     Sia-Alpha-2,3-Gal-Beta-1,4-GlcNAc-R:Alpha 2,8-Sialyltransferase2
Alpha-2,8-Sialyltransferase 8C2 3     Sialytransferase St8Sia III2
Alpha-2,8-Sialyltransferase III2 3     EC 2.4.99.-3
Sialyltransferase St8Sia III2 3     Sialyltransferase 8C3
SIAT8-C2 3     

External Ids:    HGNC: 142691   Entrez Gene: 510462   Ensembl: ENSG000001775117   OMIM: 6094785   UniProtKB: O431733   

Export aliases for ST8SIA3 gene to outside databases

Previous GC identifers: GC18P053170 GC18P051730


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ST8SIA3 Gene:
ST8SIA3 belongs to a family of sialyltransferases that form sialyl-alpha-2,8-sialyl-R linkages at the nonreducing
termini of glycoconjugates (Lee et al., 1998 (PubMed 9826427)).(supplied by OMIM, Mar 2008)

GeneCards Summary for ST8SIA3 Gene:
ST8SIA3 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3) is a protein-coding gene. Diseases associated with ST8SIA3 include pancreatitis, and endotheliitis. GO annotations related to this gene include alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity and sialic acid binding. An important paralog of this gene is ST8SIA5.

UniProtKB/Swiss-Prot: SIA8C_HUMAN, O43173
Function: May transfer sialic acid through alpha-2,8-linkages to alpha-2,3-linked and alpha-2,8-linked sialic acid
of N-linked oligosaccharides of glycoproteins and glycolipids. It can form polysialic acid in vitro directly on
alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the ST8SIA3 gene promoter:
         HOXA9B   HOXA9   p53   AP-1   AREB6   MEF-2A   FOXJ2   aMEF-2   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ST8SIA3 promoter sequence
   Search Chromatin IP Primers for ST8SIA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST8SIA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.31   Ensembl cytogenetic band:  18q21.31   HGNC cytogenetic band: 18q21.31

ST8SIA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST8SIA3 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P055019:  view genomic region     (about GC identifiers)

Start:
55,018,044 bp from pter      End:
55,038,962 bp from pter
Size:
20,919 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIA8C_HUMAN, O43173 (See protein sequence)
Recommended Name: Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase  
Size: 380 amino acids; 43970 Da
Secondary accessions: A8K0F2 Q6B085 Q9NS41

Explore the universe of human proteins at neXtProt for ST8SIA3: NX_O43173

Explore proteomics data for ST8SIA3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn93, Asn113, Asn206

  • See ST8SIA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056963.2  
    ENSEMBL proteins: 
     ENSP00000320431   ENSP00000467752  
    Reactome Protein details: O43173

    ST8SIA3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ST3G: Sialyltransferases

    2 InterPro protein domains:
     IPR001675 Glyco_trans_29
     IPR012163 Sialyl_trans

    Graphical View of Domain Structure for InterPro Entry O43173

    ProtoNet protein and cluster: O43173

    1 Blocks protein domain: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIA8C_HUMAN, O43173
    Similarity: Belongs to the glycosyltransferase 29 family


    ST8SIA3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIA8C_HUMAN, O43173
    Function: May transfer sialic acid through alpha-2,8-linkages to alpha-2,3-linked and alpha-2,8-linked sialic acid
    of N-linked oligosaccharides of glycoproteins and glycolipids. It can form polysialic acid in vitro directly on
    alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid

         Enzyme Number (IUBMB): EC 2.4.99.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003828alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA10766765
    GO:0008373sialyltransferase activity ----
    GO:0033691sialic acid binding IC9826427
         
    ST8SIA3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ST8SIA3:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ST8SIA3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ST8SIA3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ST8SIA3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ST8SIA3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ST8SIA3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ST8SIA3 (see all 120):
    hsa-miR-579 hsa-miR-26a-2* hsa-miR-520e hsa-miR-106a hsa-miR-15a hsa-miR-4272 hsa-miR-93 hsa-miR-642b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat ST8SIA3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ST8SIA3 (NM_015879)
    Sino Biological Human cDNA Clone for ST8SIA3
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST8SIA3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIA8C_HUMAN, O43173: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0030173integral component of Golgi membrane IEA--

    ST8SIA3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ST8SIA3 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Metabolism of proteins0.30
    Post-translational protein modification0.43
    N-glycan antennae elongation in the medial/trans-Golgi0.00
    Transport to the Golgi and subsequent modification0.40
    N-Glycan antennae elongation0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for ST8SIA3
        Sialic acid metabolism
    N-Glycan antennae elongation


    UniProtKB/Swiss-Prot: SIA8C_HUMAN, O43173
    Pathway: Protein modification; protein glycosylation


    ST8SIA3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ST8SIA3: 

              Glycosylation in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ST8SIA3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ST8SIA3 (O431733 ENSP000003204314) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCAM1P135913, ENSP000003184724I2D: score=1 STRING: ENSP00000318472
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001574ganglioside biosynthetic process IDA10766765
    GO:0006486protein glycosylation IDA10766765
    GO:0006491N-glycan processing IDA10766765
    GO:0006688glycosphingolipid biosynthetic process TAS9073076
    GO:0009100glycoprotein metabolic process IDA10766765

    ST8SIA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ST8SIA3 (SIA8C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ST8SIA3 gene: 
    NM_015879.2  

    Unigene Cluster for ST8SIA3:

    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
    Hs.23172  [show with all ESTs]
    Unigene Representative Sequence: NM_015879
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324000(uc002lgn.3) ENST00000586360 ENST00000590600
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ST8SIA3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ST8SIA3 (see all 120):
    hsa-miR-579 hsa-miR-26a-2* hsa-miR-520e hsa-miR-106a hsa-miR-15a hsa-miR-4272 hsa-miR-93 hsa-miR-642b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ST8SIA3
    Predesigned siRNA for gene silencing in human, mouse, rat ST8SIA3
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ST8SIA3 (NM_015879)
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ST8SIA3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ST8SIA3
      QuantiTect SYBR Green Assays in human, mouse, rat ST8SIA3
      QuantiFast Probe-based Assays in human, mouse, rat ST8SIA3

    Additional mRNA sequence: 

    AB208996.1 AF003092.2 AF004668.2 AK054939.1 AK123291.1 AK289517.1 AK313047.1 BC074909.2 

    3 DOTS entries:

    DT.407021  DT.75121663  DT.91693971 

    14 AceView cDNA sequences:

    AA074184 BC074909 AF003092 BP350109 AF004668 NM_015879 CD246043 AA063150 
    BX370279 BF433154 AA062572 BX096550 AU253291 H96110 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ST8SIA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ST8SIA3 Expression
    About this image


    ST8SIA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
             Striatum
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
    ST8SIA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ST8SIA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.23172

    UniProtKB/Swiss-Prot: SIA8C_HUMAN, O43173
    Tissue specificity: Expressed in fetal and adult brain and fetal liver

        Pathway & Disease-focused RT2 Profiler PCR Array including ST8SIA3: 
              Glycosylation in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ST8SIA3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST8SIA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ST8SIA3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St8sia31 , 5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more1, 5 92.28(n)1
    97.89(a)1
      18 (37.25 cM)5
    204511  NM_009182.31  NP_033208.21 
     642543595 
    chicken
    (Gallus gallus)
    Aves SIAT8C6
    --
    Uncharacterized protein
    95(a)
    93(a)
    1 ↔ many
    1 ↔ many
    Z(435849-440703)
    W(508990-524936)
    lizard
    (Anolis carolinensis)
    Reptilia ST8SIA36
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltra...
    90(a)
    1 ↔ 1
    GL343213.1(1963848-1987253)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia st8sia31 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more 78.25(n)
    90.26(a)
      414281  NM_001197196.1  NP_001184125.1 
    zebrafish
    (Danio rerio)
    Actinopterygii st8sia31 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more 72.1(n)
    80.21(a)
      553510  NM_001113432.2  NP_001106903.1 


    ENSEMBL Gene Tree for ST8SIA3 (if available)
    TreeFam Gene Tree for ST8SIA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ST8SIA3 gene
    ST8SIA52  ST8SIA12  ST8SIA62  ST8SIA22  ST8SIA42  
    6 SIMAP similar genes for ST8SIA3 using alignment to 2 protein entries:     SIA8C_HUMAN (see all proteins):
    ST8SIA2    ST8SIA4    SIA8F    ST8SIA6    ST8Sia VI    ST8SIA1

    ST8SIA3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ST8SIA3 (see all 391)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs5948861,2
    F--55017756(-) CAAACT/CGAACT 1 -- us2k11Minor allele frequency- C:0.08WA 118
    rs1392781701,2
    C--55017759(+) TCAGTC/TTGTAG 1 -- us2k10--------
    rs1417263261,2
    --55017783(+) CCTCTA/GTACTG 1 -- us2k10--------
    rs1832258071,2
    --55017911(+) GCTTTC/TGAAGT 1 -- us2k10--------
    rs1878056231,2
    --55017948(+) AGGTGC/TAACAC 1 -- us2k10--------
    rs1927640781,2
    --55017983(+) ATGTTG/TCCTGA 1 -- us2k10--------
    rs1824407261,2
    --55018069(+) TTTTAC/TACCTT 1 -- us2k10--------
    rs1137312211,2
    C,F--55018111(+) TTAAAA/GAAATA 1 -- us2k12Minor allele frequency- G:0.06NA 122
    rs1878989601,2
    --55018280(+) TTGTCA/GCTGGA 1 -- us2k10--------
    rs1924134761,2
    --55018428(+) TCTGCC/TGAAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ST8SIA3 (55018044 - 55038962 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ST8SIA3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677142CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ST8SIA3
    DNA2.0 Custom Variant and Variant Library Synthesis for ST8SIA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609478    OMIM disorders: --

    2 diseases for ST8SIA3:    
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    pancreatitis    endotheliitis


    ST8SIA3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ST8SIA3
    Human Genome Epidemiology (HuGE) Navigator: ST8SIA3 (1 document)

    Export disorders for ST8SIA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ST8SIA3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ST8SIA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha2,8-Sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III. (PubMed id 10766765)1, 2, 9 Angata K.... Fukuda M. (J. Biol. Chem. 2000)
    2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Cloning and expression of cDNA for a human Sia alpha 2,3Gal beta 1,4GlcNA:alpha 2,8-sialyltransferase (hST8Sia III). (PubMed id 9826427)1, 2 Lee Y.-C.... Do S.-I. (Arch. Biochem. Biophys. 1998)
    6. Molecular mechanisms involved in transcriptional activation of the human Sia-alpha2,3-Gal-beta1,4-GlcNAc-R:alpha2,8-sialyltransferase (hST8Sia III) gene induced by KCl in human glioblastoma cells. (PubMed id 16643848)1 Kim S.J....Kim C.H. (Biochem. Biophys. Res. Commun. 2006)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Cloning of the cDNA coding for rat brain CMP-NeuAc:GD3 alpha2-8 sialyltransferase. (PubMed id 9073076)1 Zeng G....Yu R.K. (Gene 1997)
    9. Molecular dissection of the ST8Sia IV polysialyltransferase. Distinct domains are required for neural cell adhesion molecule recognition and polysialylation. (PubMed id 15067013)9 Angata K....Fukuda M. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51046 HGNC: 14269 AceView: SIAT8C Ensembl:ENSG00000177511 euGenes: HUgn51046
    ECgene: ST8SIA3 H-InvDB: ST8SIA3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ST8SIA3 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST8SIA3
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_638

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ST8SIA3 gene:
    Search GeneIP for patents involving ST8SIA3

    GeneCards and IP:
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