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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ST8SIA2 Gene

protein-coding   GIFtS: 60
GCID: GC15P092937

ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase...

(Previous names: sialyltransferase 8 (alpha-2, 8-sialytransferase) B)
(Previous symbol: SIAT8B)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 21 2     ST8SiaII2 3
SIAT8B1 2 3     HsT196902
STX2 3 5     ST8SIA-II2
Sialyltransferase 8 (Alpha-2, 8-Sialytransferase) B1 2     Alpha-2,8-Sialyltransferase 8B2
Sialyltransferase 8B2 3     Alpha-2,8-Sialyltransferase 8B 12
Sialyltransferase St8Sia II2 3     Sialytransferase St8Sia II2
Sialyltransferase X2 3     EC 2.4.99.-3
SIAT8-B2 3     EC 2.4.998

External Ids:    HGNC: 108701   Entrez Gene: 81282   Ensembl: ENSG000001405577   OMIM: 6025465   UniProtKB: Q921863   

Export aliases for ST8SIA2 gene to outside databases

Previous GC identifers: GC15P090739 GC15P069073


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ST8SIA2 Gene:
The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic
acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the
Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties
of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ST8SIA2 Gene: 
ST8SIA2 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2) is a protein-coding gene. Diseases associated with ST8SIA2 include pthirus pubis infestation, and thrombotic thrombocytopenic purpura, and among its related super-pathways are WNT ligand biogenesis and trafficking and N-Glycan antennae elongation. GO annotations related to this gene include alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity and sialic acid binding. An important paralog of this gene is ST8SIA5.

UniProtKB/Swiss-Prot: SIA8B_HUMAN, Q92186
Function: May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic
acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression

Gene Wiki entry for ST8SIA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010274.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ST8SIA2 gene promoter:
         Pax-5   AML1a   AP-2alpha isoform 3   Brachyury   AP-2alpha isoform 2   ARP-1   AP-2alpha isoform 4   TGIF   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidST8SIA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ST8SIA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST8SIA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26

ST8SIA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST8SIA2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P092937:  view genomic region     (about GC identifiers)

Start:
92,937,058 bp from pter      End:
93,011,958 bp from pter
Size:
74,901 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SIA8B_HUMAN, Q92186 (See protein sequence)
Recommended Name: Alpha-2,8-sialyltransferase 8B  
Size: 375 amino acids; 42430 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
Secondary accessions: Q4VAZ0 Q92470 Q92746

Explore the universe of human proteins at neXtProt for ST8SIA2: NX_Q92186

Explore proteomics data for ST8SIA2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92186

  • 4 DME Specific Peptides for ST8SIA2 (Q92186)
     LYGFWPF  VRTAYPSL  HAVRGYWLTNKV  TGLLMYTLATRFC 

    ST8SIA2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ST8SIA2 Protein Expression
    REFSEQ proteins: NP_006002.1  
    ENSEMBL proteins: 
     ENSP00000268164   ENSP00000437382   ENSP00000450851  
    Reactome Protein details: Q92186
    Human Recombinant Protein Products for ST8SIA2: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0030173integral to Golgi membrane IEA--

    ST8SIA2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ST3G: Sialyltransferases

    2 InterPro protein domains:
     IPR001675 Glyco_trans_29
     IPR012163 Sialyl_trans

    Graphical View of Domain Structure for InterPro Entry Q92186

    ProtoNet protein and cluster: Q92186

    1 Blocks protein domain: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIA8B_HUMAN, Q92186
    Similarity: Belongs to the glycosyltransferase 29 family


    ST8SIA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIA8B_HUMAN, Q92186
    Function: May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic
    acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression

         Enzyme Numbers (IUBMB): EC 2.4.99.-1 EC 2.4.992

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003828alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA10766765
    GO:0008373sialyltransferase activity ----
    GO:0033691sialic acid binding IC10766765
         
    ST8SIA2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ST8SIA2:
     Increased cell number in G2M,  

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for St8sia2):
     behavior/neurological  cellular  growth/size  mortality/aging  nervous system 

    ST8SIA2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out St8sia2tm1Jxm for ST8SIA2

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ST8SIA2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation0.77
    Post-translational protein modification0.44
    WNT ligand biogenesis and trafficking0.77
    Metabolism of proteins0.35
    Signaling by Wnt0.62
    2N-glycan antennae elongation in the medial/trans-Golgi
    N-glycan antennae elongation in the medial/trans-Golgi0.75
    Transport to the Golgi and subsequent modification0.56
    N-Glycan antennae elongation0.75
    3Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    4NCAM signaling for neurite out-growth
    NCAM signaling for neurite out-growth0.62
    NCAM1 interactions0.62
    5Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/13        Reactome Pathways for ST8SIA2 (see all 13)
        Developmental Biology
    NCAM1 interactions
    Signaling by Wnt
    Asparagine N-linked glycosylation
    NCAM signaling for neurite out-growth


    UniProtKB/Swiss-Prot: SIA8B_HUMAN, Q92186
    Pathway: Protein modification; protein glycosylation


    ST8SIA2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ST8SIA2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/7 Interacting proteins for ST8SIA2 (Q921863 ENSP000002681644) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000229432Q6UXA73, ENSP000003994364I2D: score=1 STRING: ENSP00000399436
    C6orf15Q6UXA73I2D: score=1 
    ENSG00000206461Q6UXA73I2D: score=1 
    ENSG00000224105Q6UXA73I2D: score=1 
    ENSG00000225543Q6UXA73I2D: score=1 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001574ganglioside biosynthetic process IDA10766765
    GO:0005975carbohydrate metabolic process TAS7559389
    GO:0006464cellular protein modification process TAS7559389
    GO:0006486protein glycosylation IDA10766765
    GO:0006491N-glycan processing IDA10766765

    ST8SIA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ST8SIA2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ST8SIA2 (SIA8B)

    3 Novoseek inferred chemical compound relationships for ST8SIA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sialic acid 73.1 7 9774483 (3), 12765789 (1), 15242781 (1), 17113863 (1)
    valproic acid 40.4 1 15710344 (1)
    polysaccharide 24.7 2 9778105 (1), 17113863 (1)

    Search CenterWatch for drugs/clinical trials and news about ST8SIA2 / SIA8B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ST8SIA2 gene: 
    NM_006011.3  

    Unigene Cluster for ST8SIA2:

    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
    Hs.302341  [show with all ESTs]
    Unigene Representative Sequence: NM_006011
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268164(uc002bra.3 uc002brb.3) ENST00000539113 ENST00000555434
    ENST00000556382
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK313924.1 AY358091.1 BC069584.1 BC096202.3 BC096203.3 BC096204.3 BC096205.3 BX537981.1 
    L29556.1 U33551.1 U82762.1 

    3 DOTS entries:

    DT.91819739  DT.110978  DT.95358336 

    24/47 AceView cDNA sequences (see all 47):

    AI093905 NM_153040 BX101574 U33551 AA339648 AK057393 AI879502 AY358091 
    NM_006011 C15130 BC069584 BM669836 AW157425 BM699174 AL134628 AA488160 
    BX283248 BX332688 BM011899 BI914060 T07570 BX332687 AA906814 AI815631 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ST8SIA2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6
    SP1:                                                        -         
    SP2:              -                                         -         
    SP3:                                -                                 
    SP4:                                                                  


    ECgene alternative splicing isoforms for ST8SIA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ST8SIA2 expression in normal human tissues (normalized intensities)      ST8SIA2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACTTACCA
    ST8SIA2 Expression
    About this image


    ST8SIA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Hypothalamus
             midbrain   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Eye (Sensory Organs)
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium

    See ST8SIA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ST8SIA2

    SOURCE GeneReport for Unigene cluster: Hs.302341

    UniProtKB/Swiss-Prot: SIA8B_HUMAN, Q92186
    Tissue specificity: Highly expressed in fetal brain, kidney and heart and to a much lesser extent in adult heart
    and thymus

        SABiosciences Expression via Pathway-Focused PCR Array including ST8SIA2: 
              Glycosylation in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST8SIA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ST8SIA2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St8sia21 , 5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more1, 5 92.18(n)1
    97.87(a)1
      7 (42.27 cM)5
    204501  NM_009181.21  NP_033207.21 
     739391195 
    chicken
    (Gallus gallus)
    Aves ST8SIA21 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more 84.44(n)
    89.6(a)
      414336  NM_001001604.1  NP_001001604.1 
    lizard
    (Anolis carolinensis)
    Reptilia ST8SIA26
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltra...
    86(a)
    1 ↔ 1
    GL343392.1(777376-796525)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3977022 alpha-2,8-polysialyltransferase 75.22(n)    AB007468.1 
    zebrafish
    (Danio rerio)
    Actinopterygii siat82 sialyltransferase 8 74.41(n)   266636  BC050483.1 


    ENSEMBL Gene Tree for ST8SIA2 (if available)
    TreeFam Gene Tree for ST8SIA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ST8SIA2 gene
    ST8SIA52  ST8SIA12  ST8SIA62  ST8SIA32  ST8SIA42  
    7 SIMAP similar genes for ST8SIA2 using alignment to 6 protein entries:     SIA8B_HUMAN (see all proteins):
    ST8SIA4    ST8SIA3    SIA8F    ST8SIA5    ST8SIA1    ST8SIA6
    ST8Sia VI

    ST8SIA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1735 SNPs in ST8SIA2 are shown (see all 1735)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1880296041,2
    --92935225(+) GGTATC/TCCAAC 1 -- us2k10--------
    rs1925630151,2
    --92935264(+) GATGAC/GAAAAA 1 -- us2k10--------
    rs37599191,2
    C,F,H--92935272(-) TGGAGA/TGGTTT 1 -- us2k118Minor allele frequency- T:0.37NA NS EA WA CSA 917
    rs37599181,2
    C,F,A,H--92935306(-) CCTTTT/GTCTTG 1 -- us2k127Minor allele frequency- G:0.42EA NA NS WA CSA 3965
    rs1411046621,2
    --92935313(+) AAGGGA/CAAGAT 1 -- us2k10--------
    rs727661401,2
    C,F--92935372(+) CCACAC/TTGATG 1 -- us2k11Minor allele frequency- T:0.06NA 120
    rs37599171,2
    C,F,H--92935447(-) GATGTG/TGAGAA 1 -- us2k132Minor allele frequency- T:0.48EA NA NS WA CSA 4473
    rs772770301,2
    F--92935472(+) CCAAGA/GAAAAT 1 -- us2k11Minor allele frequency- G:0.08WA 118
    rs37847461,2
    C,F,H--92935629(-) TCTGCA/CTCACC 1 -- us2k118Minor allele frequency- C:0.28EA NS NA WA CSA 2274
    rs1434193641,2
    --92935647(+) CTTGAC/TGCTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ST8SIA2 (92937058 - 93011958 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ST8SIA2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv904499CNV Gain21882294


    Human Gene Mutation Database (HGMD): ST8SIA2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ST8SIA2
    DNA2.0 Custom Variant and Variant Library Synthesis for ST8SIA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602546    OMIM disorders: --

    14 diseases for ST8SIA2:    About MalaCards
    pthirus pubis infestation    thrombotic thrombocytopenic purpura    bipolar i disorder    hemolytic-uremic syndrome
    purpura    shigellosis    leukodystrophy    gastroenteritis
    thrombocytopenia    diarrhea    mood disorder    schizophrenia
    neuroblastoma    lung cancer

    6 diseases from the University of Copenhagen DISEASES database for ST8SIA2:
    Anemia     Diarrhea     Thrombotic thrombocytopenic purpura     Kidney failure
    Thrombocytopenia     Gastroenteritis

    ST8SIA2 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for ST8SIA2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nsclc 17.8 3 11245481 (1), 10850459 (1)
    schizophrenia 15.4 12 17126533 (6), 16229822 (3)
    tumors 0 10 11089916 (2), 16450393 (2), 10850459 (2), 11245481 (1)
    cancer 0 2 11245481 (1), 10850459 (1)

    Genetic Association Database (GAD): ST8SIA2
    Human Genome Epidemiology (HuGE) Navigator: ST8SIA2 (5 documents)

    Export disorders for ST8SIA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ST8SIA2 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with ST8SIA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human STX cDNA confers polysialic acid expression in mammalian cells. (PubMed id 7559389)1, 2, 3 Scheidegger E.P.... Lowe J.B. (1995)
    2. Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia. (PubMed id 16229822)1, 4, 9 Arai M....Itokawa M. (2006)
    3. Human STX polysialyltransferase forms the embryonic form of the neural cell adhesion molecule. Tissue-specific expression, neurite outgrowth, and chromosomal localization in comparison with another polysialyltransferase, PST. (PubMed id 9054414)1, 2, 9 Angata K.... Fukuda M. (1997)
    4. Positive association between SIAT8B and schizophrenia in the Chinese Han population. (PubMed id 17126533)1, 4, 9 Tao R....He L. (2007)
    5. A genome-wide scan for common alleles affecting risk for autism. (PubMed id 20663923)1, 4 Anney R....Hallmayer J. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Differential expression of five sialyltransferase genes in human tissues. (PubMed id 8027041)1, 2 Kitagawa H. and Paulson J.C. (1994)
    8. ST8Sia II and ST8Sia IV polysialyltransferases exhibit marked differences in utilizing various acceptors containing oligosialic acid and short polysialic acid. The basis for cooperative polysialylation by two enzymes. (PubMed id 12138100)1, 9 Angata K....Fukuda M. (2002)
    9. Characterization of mouse ST8Sia II (STX) as a neural cell adhesion molecule-specific polysialic acid synthase. Requirement of core alpha1,6-linked fucose and a polypeptide chain for polysialylation. (PubMed id 8702635)1, 9 Kojima N....Tsuji S. (1996)
    10. Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha2,8-Sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III. (PubMed id 10766765)1, 9 Angata K.... Fukuda M. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8128 HGNC: 10870 AceView: SIAT8BandFLJ32831 Ensembl:ENSG00000140557 euGenes: HUgn8128
    ECgene: ST8SIA2 H-InvDB: ST8SIA2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ST8SIA2 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST8SIA2
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_637

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ST8SIA2 gene:
    Search GeneIP for patents involving ST8SIA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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