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Aliases for ST8SIA2 Gene

Aliases for ST8SIA2 Gene

  • ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 2 2 3
  • STX 3 4 6
  • Sialyltransferase 8 (Alpha-2, 8-Sialytransferase) B 2 3
  • Sialyltransferase St8Sia II 3 4
  • Sialyltransferase 8B 3 4
  • Sialyltransferase X 3 4
  • ST8SiaII 3 4
  • SIAT8-B 3 4
  • SIAT8B 3 4
  • Alpha-2,8-Sialyltransferase 8B 1 3
  • Alpha-2,8-Sialyltransferase 8B 3
  • Sialytransferase St8Sia II 3
  • EC 2.4.99.- 4
  • ST8SIA-II 3
  • EC 2.4.99 63
  • HsT19690 3

External Ids for ST8SIA2 Gene

Previous HGNC Symbols for ST8SIA2 Gene

  • SIAT8B

Previous GeneCards Identifiers for ST8SIA2 Gene

  • GC15P090739
  • GC15P092937
  • GC15P069073

Summaries for ST8SIA2 Gene

Entrez Gene Summary for ST8SIA2 Gene

  • The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST8SIA2 Gene

ST8SIA2 (ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 2) is a Protein Coding gene. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include sialic acid binding and alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. An important paralog of this gene is ST8SIA1.

UniProtKB/Swiss-Prot for ST8SIA2 Gene

  • May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression

Gene Wiki entry for ST8SIA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST8SIA2 Gene

Genomics for ST8SIA2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ST8SIA2 Gene

Start:
92,393,828 bp from pter
End:
92,468,728 bp from pter
Size:
74,901 bases
Orientation:
Plus strand

Genomic View for ST8SIA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ST8SIA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST8SIA2 Gene

Proteins for ST8SIA2 Gene

  • Protein details for ST8SIA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92186-SIA8B_HUMAN
    Recommended name:
    Alpha-2,8-sialyltransferase 8B
    Protein Accession:
    Q92186
    Secondary Accessions:
    • Q4VAZ0
    • Q92470
    • Q92746

    Protein attributes for ST8SIA2 Gene

    Size:
    375 amino acids
    Molecular mass:
    42430 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST8SIA2 Gene

Proteomics data for ST8SIA2 Gene at MOPED

Selected DME Specific Peptides for ST8SIA2 Gene

Post-translational modifications for ST8SIA2 Gene

  • Glycosylation at Asn60, Asn72, Asn89, Asn134, Asn219, and Asn234
  • Modification sites at PhosphoSitePlus

Other Protein References for ST8SIA2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ST8SIA2 ("ST8 alpha-2,8-Sialyltransferase 8B/ST8SIA2")

Domains for ST8SIA2 Gene

Gene Families for ST8SIA2 Gene

HGNC:
  • ST3G :Sialyltransferases

Protein Domains for ST8SIA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q92186

UniProtKB/Swiss-Prot:

SIA8B_HUMAN :
  • Q92186
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST8SIA2: view

Function for ST8SIA2 Gene

Molecular function for ST8SIA2 Gene

UniProtKB/Swiss-Prot Function: May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression

Enzyme Numbers (IUBMB) for ST8SIA2 Gene

Gene Ontology (GO) - Molecular Function for ST8SIA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA 10766765
GO:0008373 sialyltransferase activity --
GO:0033691 sialic acid binding IC 10766765
genes like me logo Genes that share ontologies with ST8SIA2: view

Phenotypes for ST8SIA2 Gene

genes like me logo Genes that share phenotypes with ST8SIA2: view

Animal Models for ST8SIA2 Gene

MGI Knock Outs for ST8SIA2:

Animal Model Products

CRISPR Products

miRNA for ST8SIA2 Gene

miRTarBase miRNAs that target ST8SIA2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ST8SIA2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for ST8SIA2 Gene

Localization for ST8SIA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST8SIA2 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST8SIA2 Gene COMPARTMENTS Subcellular localization image for ST8SIA2 gene
Compartment Confidence
golgi apparatus 5
cytosol 2
endoplasmic reticulum 2
endosome 2
extracellular 2
plasma membrane 2
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ST8SIA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005769 early endosome IEA --
GO:0030173 integral component of Golgi membrane IEA --
GO:0055037 recycling endosome IEA --
genes like me logo Genes that share ontologies with ST8SIA2: view

Pathways for ST8SIA2 Gene

genes like me logo Genes that share pathways with ST8SIA2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q92186-SIA8B_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for ST8SIA2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000268164%0d%0a9606.ENSP00000358565%0d%0a9606.ENSP00000318472%0d%0a
Selected Interacting proteins: ENSP00000268164 Q92186-SIA8B_HUMAN for ST8SIA2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ST8SIA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001574 ganglioside biosynthetic process IDA 10766765
GO:0005975 carbohydrate metabolic process TAS 7559389
GO:0006464 cellular protein modification process TAS 7559389
GO:0006486 protein glycosylation IDA 10766765
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
genes like me logo Genes that share ontologies with ST8SIA2: view

Compounds for ST8SIA2 Gene

(3) Novoseek inferred chemical compound relationships for ST8SIA2 Gene

Compound -log(P) Hits PubMed IDs
sialic acid 73.1 6
valproic acid 40.4 1
polysaccharide 24.7 2
genes like me logo Genes that share compounds with ST8SIA2: view

Transcripts for ST8SIA2 Gene

mRNA/cDNA for ST8SIA2 Gene

Unigene Clusters for ST8SIA2 Gene

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ST8SIA2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST8SIA2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for ST8SIA2 Gene

GeneLoc Exon Structure for
ST8SIA2
ECgene alternative splicing isoforms for
ST8SIA2

Expression for ST8SIA2 Gene

mRNA expression in normal human tissues for ST8SIA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST8SIA2 Gene

This gene is overexpressed in Heart - Left Ventricle (9.3), Brain - Hypothalamus (5.8), Brain - Hippocampus (5.1), and Brain - Anterior cingulate cortex (BA24) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ST8SIA2 Gene

SOURCE GeneReport for Unigene cluster for ST8SIA2 Gene Hs.302341

mRNA Expression by UniProt/SwissProt for ST8SIA2 Gene

Q92186-SIA8B_HUMAN
Tissue specificity: Highly expressed in fetal brain, kidney and heart and to a much lesser extent in adult heart and thymus
genes like me logo Genes that share expressions with ST8SIA2: view

In Situ Assay Products

Orthologs for ST8SIA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST8SIA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST8SIA2 35
  • 99.2 (n)
  • 99.47 (a)
ST8SIA2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ST8SIA2 35
  • 92.62 (n)
  • 98.63 (a)
ST8SIA2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ST8SIA2 35
  • 92.47 (n)
  • 97.89 (a)
ST8SIA2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St8sia2 35
  • 92.18 (n)
  • 97.87 (a)
St8sia2 16
St8sia2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ST8SIA2 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ST8SIA2 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia St8sia2 35
  • 91.2 (n)
  • 97.6 (a)
chicken
(Gallus gallus)
Aves ST8SIA2 35
  • 84.44 (n)
  • 89.6 (a)
ST8SIA2 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST8SIA2 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397702 35
tropical clawed frog
(Silurana tropicalis)
Amphibia st8sia2 35
  • 73.33 (n)
  • 80.27 (a)
zebrafish
(Danio rerio)
Actinopterygii siat8 35
st8sia2 35
  • 62.99 (n)
  • 63.98 (a)
st8sia2 36
  • 61 (a)
OneToOne
Species with no ortholog for ST8SIA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST8SIA2 Gene

ENSEMBL:
Gene Tree for ST8SIA2 (if available)
TreeFam:
Gene Tree for ST8SIA2 (if available)

Paralogs for ST8SIA2 Gene

Paralogs for ST8SIA2 Gene

Selected SIMAP similar genes for ST8SIA2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ST8SIA2: view

Variants for ST8SIA2 Gene

Sequence variations from dbSNP and Humsavar for ST8SIA2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs716628 -- 92,400,543(+) GCTAT(A/G)ACGTT intron-variant
rs722645 -- 92,400,093(+) CTTGC(A/G)CACAC intron-variant
rs881770 -- 92,406,579(+) CTTCT(A/G)CAGAG intron-variant
rs897463 -- 92,457,211(-) CAGGA(A/T)TGCCT intron-variant
rs921846 -- 92,400,736(+) CCCAC(A/G)GTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST8SIA2 Gene

Variant ID Type Subtype PubMed ID
nsv904499 CNV Gain 21882294

Relevant External Links for ST8SIA2 Gene

HapMap Linkage Disequilibrium report
ST8SIA2
Human Gene Mutation Database (HGMD)
ST8SIA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST8SIA2 Gene

Disorders for ST8SIA2 Gene

(4) Novoseek inferred disease relationships for ST8SIA2 Gene

Disease -log(P) Hits PubMed IDs
nsclc 17.8 2
schizophrenia 15.4 9
tumors 0 7
cancer 0 2

Relevant External Links for ST8SIA2

Genetic Association Database (GAD)
ST8SIA2
Human Genome Epidemiology (HuGE) Navigator
ST8SIA2
genes like me logo Genes that share disorders with ST8SIA2: view

No data available for UniProtKB/Swiss-Prot for ST8SIA2 Gene

Publications for ST8SIA2 Gene

  1. Human STX polysialyltransferase forms the embryonic form of the neural cell adhesion molecule. Tissue-specific expression, neurite outgrowth, and chromosomal localization in comparison with another polysialyltransferase, PST. (PMID: 9054414) Angata K. … Fukuda M. (J. Biol. Chem. 1997) 3 4 23
  2. Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia. (PMID: 16229822) Arai M. … Itokawa M. (Biol. Psychiatry 2006) 3 23 48
  3. Positive association between SIAT8B and schizophrenia in the Chinese Han population. (PMID: 17126533) Tao R. … He L. (Schizophr. Res. 2007) 3 23 48
  4. A human STX cDNA confers polysialic acid expression in mammalian cells. (PMID: 7559389) Scheidegger E.P. … Lowe J.B. (J. Biol. Chem. 1995) 2 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ST8SIA2 Gene

Sources for ST8SIA2 Gene

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