ST8SIA1 Gene

Aliases
for ST8SIA1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Previous GC identifer: GC12M022246

Summaries
for ST8SIA1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Genomic Views
for ST8SIA1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000012.11  NT_009714.18  NC_018923.2  

SwitchGear Promoter luciferase reporter plasmid: ST8SIA1 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST8SIA1

ST8SIA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M022119:  view genomic region     (about GC identifiers)

Proteins
for ST8SIA1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

Explore the universe of human proteins at neXtProt for ST8SIA1: NX_Q92185

Explore proteomics data for ST8SIA1 at MOPED

Post-translational modifications: 

ST8SIA1 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for ST8SIA1 (ST8 alpha-2,8-Sialyltransferase 8A/ST8SIA1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for ST8SIA1 OriGene Custom MassSpec OriGene Custom Protein Services for ST8SIA1
	GenScript Custom Purified and Recombinant Proteins Services for ST8SIA1
	Novus Biologicals ST8SIA1 Proteins Novus Biologicals ST8SIA1 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for ST8SIA1
	Search GeneTex for Proteins for ST8SIA1
	antibodies-online proteins for ST8SIA1 (4 products)
	antibodies-online peptides for ST8SIA1

ST8SIA1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for ST8SIA1 (ST8 alpha-2,8-Sialyltransferase 8A/ST8SIA1)
	Browse OriGene Antibodies OriGene Custom Antibody Services for ST8SIA1
	Novus Biologicals ST8SIA1 Antibodies
	Abcam antibodies for ST8SIA1
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for ST8SIA1
	antibodies-online antibodies for ST8SIA1 (4 products)

ST8SIA1 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for ST8SIA1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ST8SIA1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for ST8SIA1
	antibodies-online kits for ST8SIA1 (6 products)

Domains /
Families
for ST8SIA1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

ProtoNet protein and cluster: Q92185

Find genes that share domains with ST8SIA1           About GenesLikeMe

Function
for ST8SIA1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

     Enzyme Number (IUBMB): EC 2.4.99.8^{1 2}

     Gene Ontology (GO): 2 molecular function terms:    About this table

(inferred from 2 alleles) (MGI details for St8sia1)

genOway: Develop your customized and physiologically relevant rodent model for ST8SIA1

miRNA Products:		Block miRNA regulation of human, mouse, rat ST8SIA1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate ST8SIA1 (see all 79):
		hsa-miR-3194-5p hsa-miR-361-5p hsa-miR-890 hsa-miR-629* hsa-miR-376a* hsa-miR-130a* hsa-miR-3065-5p hsa-miR-23c
		SwitchGear 3'UTR luciferase reporter plasmid: ST8SIA1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ST8SIA1
		Predesigned siRNA for gene silencing in human, mouse, rat ST8SIA1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ST8SIA1

Clone Products:		OriGene clones in human, mouse for ST8SIA1 (see all 7) OriGene ORF clones in mouse, rat for ST8SIA1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ST8SIA1 (NM_003034)
		Sino Biological Human cDNA Clone for ST8SIA1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST8SIA1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST8SIA1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ST8SIA1
		Browse ESI BIO Cell Lines and PureStem Progenitors for ST8SIA1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST8SIA1

Localization
for ST8SIA1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
golgi apparatus	5
mitochondrion	2
extracellular	1
nucleus	1
plasma membrane	1

About this image

Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for ST8SIA1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for ST8SIA1 About     See pathways by source

Powered by

	SuperPath	Contained pathways About
1	Glycosphingolipid biosynthesis - ganglio series	Ganglio Sphingolipid Metabolism 0.53 Glycosphingolipid biosynthesis - ganglio series 0.53
2	Metabolism	Metabolic pathways 0.38
3	Glycosphingolipid biosynthesis - lacto and neolacto series	Glycosphingolipid biosynthesis - lacto and neolacto series
4	Glycosphingolipid biosynthesis - globo series	Glycosphingolipid biosynthesis - globo series

1 BioSystems Pathway for ST8SIA1

Ganglio Sphingolipid Metabolism

1 Reactome Pathway for ST8SIA1

Sialic acid metabolism

4 Kegg Pathways  (Kegg details for ST8SIA1)

	Glycosphingolipid biosynthesis - lacto and neolacto series
	Glycosphingolipid biosynthesis - globo series
	Glycosphingolipid biosynthesis - ganglio series
	Metabolic pathways

    Custom Pathway & Disease-focused RT² Profiler PCR Arrays for ST8SIA1
Interactions:

    Search GeneGlobe Interaction Network for ST8SIA1

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

Selected Interacting proteins for ST8SIA1 (ENSP00000379353⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

Drugs & Compounds
for ST8SIA1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Transcripts
for ST8SIA1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

Expression
for ST8SIA1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ST8SIA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TCTTTTTCTT

About this image

Brain (Nervous System)    fully expand to see all 3 entries
Choroid Plexus Progenitor Cells Choroid Plexus
Cerebral Cortex
Blood (Cardiovascular System)    fully expand to see all 2 entries
Common Dendritic Cell Precursors Hematopoietic Bone Marrow
Bone (Muscoskeletal System)
Bone Marrow
Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast
Ovary (Reproductive System)
Oviduct

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for ST8SIA1
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ST8SIA1
		QuantiTect SYBR Green Assays in human, mouse, rat ST8SIA1
		QuantiFast Probe-based Assays in human, mouse, rat ST8SIA1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST8SIA1

Orthologs
for ST8SIA1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

Paralogs
for ST8SIA1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for ST8SIA1 gene

ST8SIA5²  ST8SIA6²  ST8SIA3²  ST8SIA2²  ST8SIA4²  

8 SIMAP similar genes for ST8SIA1 using alignment to 7 protein entries:     SIA8A_HUMAN (see all proteins):

SIA8F    ST8SIA6    ST8Sia VI    ST8SIA5    ST3GAL1    ST8SIA3

ST8SIA2    ST8SIA4

Find genes that share paralogs with ST8SIA1           About GenesLikeMe

Genomic Variants
for ST8SIA1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Selected SNPs for ST8SIA1 (see all 2765)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1430071361,2	C	--	22345899(+)	AGACT-/AAAAGG	1	--	ds5001		0	--	--	--	--
rs1513387141,2		--	22345909(+)	GCACAC/TTTGGG	1	--	ds5001		0	--	--	--	--
rs567144181,2	F	--	22346208(+)	ATGACT/GTTTCA	1	--	ds5001		1		EA	120
rs1394460091,2		--	22346254(+)	ATACAA/TAACAA	1	--	ds5001		0	--	--	--	--
rs1449886881,2		--	22346260(+)	AACAAA/GGCAGG	1	--	ds5001		0	--	--	--	--
rs1157864461,2	F	--	22346284(+)	AGAGCG/ATCACC	1	--	ds5001		1		WA	118
rs1809226371,2		--	22346289(+)	GTCACC/TCATTT	1	--	ds5001		0	--	--	--	--
rs774316651,2	C,F	--	22346402(+)	CTTACC/TGAACC	1	--	ut31		1		EA	120
rs1859613701,2	C	--	22346423(+)	CAGCCA/GTAATT	1	--	ut31		0	--	--	--	--
rs1116317141,2	C,F	--	22346448(+)	AAAGAA/TAAAGA	1	--	ut31		2		CSA WA	120

HapMap Linkage Disequilibrium report for ST8SIA1 (22216707 - 22466707 bp, first 250kb of ST8SIA1)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for ST8SIA1:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv435637	CNV	Deletion	17901297
esv269014	CNV	Insertion	20981092
nsv521274	CNV	Loss	19592680
esv23565	CNV	Loss	19812545
nsv482978	CNV	Loss	15286789
esv33913	CNV	Gain	17666407
essv12236	CNV	CNV	17122850
essv14178	CNV	CNV	17122850
dgv482e1	CNV	Complex	17122850

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ST8SIA1

DNA2.0 Custom Variant and Variant Library Synthesis for ST8SIA1

Disorders / Diseases
for ST8SIA1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

Publications
for ST8SIA1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ST8SIA1 gene, integrated from 10 sources (see all 44): (articles sorted by number of sources associating them with ST8SIA1)

Utopia: connect your pdf to the dynamic world of online information

1. Variants of ST8SIA1 are associated with risk of developing multiple sclerosis. (PubMed id 18612409)^{1, 4, 9} Husain S....Vitale E. (PLoS ONE 2008)
2. Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families. (PubMed id 19428123)^{1, 4, 9} Ramagopalan S.V....Ebers G.C. (J. Neuroimmunol. 2009)
3. Isolation of GD3 synthase gene by expression cloning of GM3 alpha- 2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody. (PubMed id 7937974)^{1, 2, 9} Haraguchi M.... Furukawa K. (Proc. Natl. Acad. Sci. U.S.A. 1994)
4. Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. (PubMed id 20708005)^{1, 4} Chalasani N....Rotter J.I. (Gastroenterology 2010)
5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
7. Expression cloning of a human GT3 synthase. GD3 and GT3 are synthesized by a single enzyme. (PubMed id 8631981)^{1, 2} Nakayama J.... Fukuda M. (J. Biol. Chem. 1996)
8. Expression cloning of a GM3-specific alpha-2,8-sialyltransferase (GD3 synthase). (PubMed id 8195250)^{1, 2} Sasaki K.... Nishi T. (J. Biol. Chem. 1994)
9. Expression cloning of a CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase (GD3 synthase) from human melanoma cells. (PubMed id 8058740)^{1, 2} Nara K.... Sanai Y. (Proc. Natl. Acad. Sci. U.S.A. 1994)
10. Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3- sialyltransferase using lectin resistance selection. (PubMed id 7901202)^{1, 3} Sasaki K.... Hasegawa M. (J. Biol. Chem. 1993)

External Searches for ST8SIA1 gene

Genome Databases showing ST8SIA1 gene

Other Databases showing ST8SIA1 gene

Specialized Databases showing ST8SIA1 gene

Products
for ST8SIA1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section