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ST8SIA1 Gene

protein-coding GIFtS: 59
GCID: GC12M022119

ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase...

(Previous names: sialyltransferase 8 (alpha-N-acetylneuraminate: alpha-2,8-sialytransferase,...)
(Previous symbols: SIAT8, SIAT8A)

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 1¹ ²		EC 2.4.99.8³ ⁸
SIAT8¹ ² ³ ⁵		ST8Sia I¹
SIAT8A¹ ² ³		GD3S²
Sialyltransferase 8 (Alpha-N-Acetylneuraminate: Alpha-2,8-Sialytransferase, GD3 Synthase) A¹ ²		Alpha-N-Acetylneuraminide Alpha-2,8-Sialyltransferase²
Alpha-2,8-Sialyltransferase 8A² ³		Disialoganglioside (GD3) Synthase²
Ganglioside GD3 Synthase² ³		Ganglioside-Specific Alpha-2,8-Polysialyltransferase²
Ganglioside GT3 Synthase² ³		Sialyltransferase 8A (Alpha-N-Acetylneuraminate: Alpha-2,8-Sialyltransferase, GD3 Synthase)²
Sialyltransferase St8Sia I² ³		Sialytransferase St8Sia I²
SIAT8-A² ³		Sialyltransferase 8A³
ST8SiaI² ³

External Ids:	HGNC: 10869¹	Entrez Gene: 6489²	Ensembl: ENSG00000111728⁷	OMIM: 601123⁵	UniProtKB: Q92185³

ORGUL members:

Export aliases for ST8SIA1 gene to outside databases

Previous GC identifer: GC12M022246

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ST8SIA1 Gene:

Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be

important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II

membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides

GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase

family 29. (provided by RefSeq, Jul 2008)

GeneCards Summary for ST8SIA1 Gene:

ST8SIA1 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1) is a protein-coding gene. Diseases associated with ST8SIA1 include fatty liver disease, and liver disease. GO annotations related to this gene include alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity and sialyltransferase activity. An important paralog of this gene is ST8SIA5.

UniProtKB/Swiss-Prot: SIA8A_HUMAN, Q92185

Function: Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex

glycosphinglolipds that contain one or more residues of sialic acid

Gene Wiki entry for ST8SIA1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000012.12 NT_009714.18 NC_018923.2

Regulatory elements:

Regulatory transcription factor binding sites in the ST8SIA1 gene promoter:
GR HOXA9B HOXA9 CUTL1 Gfi-1 Meis-1b C/EBPalpha RORalpha1 GR-alpha Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ST8SIA1 promoter sequence

Search Chromatin IP Primers for ST8SIA1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST8SIA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.1-p11.2 Ensembl cytogenetic band: 12p12.1 HGNC cytogenetic band: 12p12.1-p11.2

ST8SIA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST8SIA1 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M022119: view genomic region (about GC identifiers)

Start:	22,216,707 bp from pter	End:	22,589,975 bp from pter
Size:	373,269 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SIA8A_HUMAN, Q92185 (See protein sequence)

Recommended Name: Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

Size: 356 amino acids; 40519 Da

Sequence caution: Sequence=AAC37586.1; Type=Erroneous initiation; Sequence=CAA54891.1; Type=Erroneous initiation;

Secondary accessions: A8K4H6 Q17RL0 Q6PZN5 Q93064

Alternative splicing: 2 isoforms: Q92185-1 Q92185-2

Explore the universe of human proteins at neXtProt for ST8SIA1: NX_Q92185

Explore proteomics data for ST8SIA1 at MOPED

Post-translational modifications:

Glycosylation² at Asn71, Asn119, Asn214, Asn245

Selected DME Specific Peptides for ST8SIA1 (Q92185) (see all 6)

WPFSVNM

PSLRVYYTL

GKFWKSRGIH

HAMPEEFLQLW

See ST8SIA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_003025.1

ENSEMBL proteins:

ENSP00000379353 ENSP00000261197 ENSP00000441707 ENSP00000444999 ENSP00000440292

ENSP00000384467 ENSP00000370832 ENSP00000446363

Reactome Protein details: Q92185

ST8SIA1 Human Recombinant Protein Products:

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	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

ST3G: Sialyltransferases

2 InterPro protein domains:

IPR001675 Glyco_trans_29

IPR012163 Sialyl_trans

Graphical View of Domain Structure for InterPro Entry Q92185

ProtoNet protein and cluster: Q92185

1 Blocks protein domain: IPB001675 Glycosyl transferase

UniProtKB/Swiss-Prot: SIA8A_HUMAN, Q92185

Similarity: Belongs to the glycosyltransferase 29 family

ST8SIA1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: SIA8A_HUMAN, Q92185

Function: Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex

glycosphinglolipds that contain one or more residues of sialic acid

Catalytic activity: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP +

alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R

Enzyme Number (IUBMB): EC 2.4.99.8¹ ²

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	IEA	--
GO:0008373	sialyltransferase activity	TAS	8195250

ST8SIA1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ST8SIA1:

Increased G2M DNA content

8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for St8sia1):

behavior/neurological	hematopoietic system	immune system	mortality/aging	nervous system
normal	reproductive system	respiratory system

ST8SIA1 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out St8sia1^tm1Kfk for ST8SIA1

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ST8SIA1

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ST8SIA1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ST8SIA1

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ST8SIA1

miRNA Products:		Block miRNA regulation of human, mouse, rat ST8SIA1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate ST8SIA1 (see all 79):
		hsa-miR-3194-5p hsa-miR-361-5p hsa-miR-890 hsa-miR-629* hsa-miR-376a* hsa-miR-130a* hsa-miR-3065-5p hsa-miR-23c

		SwitchGear 3'UTR luciferase reporter plasmid: ST8SIA1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ST8SIA1
		Predesigned siRNA for gene silencing in human, mouse, rat ST8SIA1

Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ST8SIA1
		Browse ESI BIO Cell Lines and PureStem Progenitors for ST8SIA1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST8SIA1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

SIA8A_HUMAN, Q92185: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
golgi apparatus	5
mitochondrion	2
extracellular	1
nucleus	1
plasma membrane	1

About this image

Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005794	Golgi apparatus	--	--
GO:0016021	integral component of membrane	TAS	8195250
GO:0030173	integral component of Golgi membrane	IEA	--

ST8SIA1 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ST8SIA1 About

See pathways by source

SuperPath

Contained pathways About

Glycosphingolipid biosynthesis - ganglio series

Ganglio Sphingolipid Metabolism

0.53

Glycosphingolipid biosynthesis - ganglio series

0.53

Metabolism

Metabolic pathways

0.38

Glycosphingolipid biosynthesis - lacto and neolacto series

Glycosphingolipid biosynthesis - lacto and neolacto series

Glycosphingolipid biosynthesis - globo series

Glycosphingolipid biosynthesis - globo series

Pathways by source See SuperPaths
Show all pathways

1 BioSystems Pathway for ST8SIA1

Ganglio Sphingolipid Metabolism

1 Reactome Pathway for ST8SIA1

Sialic acid metabolism

4 Kegg Pathways (Kegg details for ST8SIA1):

	Glycosphingolipid biosynthesis - lacto and neolacto series
	Glycosphingolipid biosynthesis - globo series
	Glycosphingolipid biosynthesis - ganglio series
	Metabolic pathways

UniProtKB/Swiss-Prot: SIA8A_HUMAN, Q92185

Pathway: Protein modification; protein glycosylation

Pathway: Lipid metabolism; sphingolipid metabolism

ST8SIA1 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT² Profiler PCR Arrays for ST8SIA1
Interactions:

  Search GeneGlobe Interaction Network for ST8SIA1

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

Selected Interacting proteins for ST8SIA1 (ENSP00000379353⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
B4GALNT1	ENSP00000341562⁴	STRING: ENSP00000341562
FUT3	ENSP00000305603⁴	STRING: ENSP00000305603
FUT4	ENSP00000351602⁴	STRING: ENSP00000351602
FUT5	ENSP00000252675⁴	STRING: ENSP00000252675
FUT6	ENSP00000286955⁴	STRING: ENSP00000286955

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Gene Ontology (GO): Selected biological process terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	8195250
GO:0006486	protein glycosylation	IEA	--
GO:0006688	glycosphingolipid biosynthetic process	TAS	8195250
GO:0008284	positive regulation of cell proliferation	IEA	--
GO:0034605	cellular response to heat	IEA	--

ST8SIA1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for ST8SIA1 (SIA8A)

Selected HMDB Compounds for ST8SIA1 (see all 86) About this table

Compound	CAS #	PubMed Ids
Ganglioside GM1 (d18:0/12:0)	--	12486725
Ganglioside GM1 (d18:0/14:0)	--	12486725
Ganglioside GM1 (d18:0/16:0)	--	12486725
Ganglioside GM1 (d18:0/18:0)	--	12486725
Ganglioside GM1 (d18:0/18:1(11Z))	--	12486725
Ganglioside GM1 (d18:0/18:1(9Z))	--	12486725
Ganglioside GM1 (d18:0/20:0)	--	12486725
Ganglioside GM1 (d18:0/22:0)	--	12486725
Ganglioside GM1 (d18:0/22:1(13Z))	--	12486725
Ganglioside GM1 (d18:0/23:0)	--	12486725

2 Novoseek inferred chemical compound relationships for ST8SIA1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ganglioside	76.1	6	19125296 (2), 7937974 (1), 18058224 (1), 19428123 (1)
sialic acid	45.6	1	16014806 (1)

ST8SIA1 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ST8SIA1 gene:

NM_003034.3

Unigene Cluster for ST8SIA1:

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

Hs.408614 [show with all ESTs]

Unigene Representative Sequence: NM_003034

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000536535 ENST00000544732 ENST00000537795 ENST00000545524 ENST00000396037(uc001rfo.4)

ENST00000261197(uc009zix.3) ENST00000545494 ENST00000508924 ENST00000540824

ENST00000538256 ENST00000541868 ENST00000404299 ENST00000536558 ENST00000381424

ENST00000545185 ENST00000539510

miRNA Products:		Block miRNA regulation of human, mouse, rat ST8SIA1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate ST8SIA1 (see all 79):
		hsa-miR-3194-5p hsa-miR-361-5p hsa-miR-890 hsa-miR-629* hsa-miR-376a* hsa-miR-130a* hsa-miR-3065-5p hsa-miR-23c

		SwitchGear 3'UTR luciferase reporter plasmid: ST8SIA1 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: ST8SIA1 (NM_003034)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST8SIA1

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		QuantiTect SYBR Green Assays in human, mouse, rat ST8SIA1
		QuantiFast Probe-based Assays in human, mouse, rat ST8SIA1

Additional mRNA sequence:

AF088002.1 AK290941.1 AK297310.1 AK315340.1 AY569975.1 BC031081.1 BC046158.1 BC117285.1

BC126162.1 D26360.1 EU041716.1 L32867.1 L43494.1 X77922.1

12 DOTS entries:

DT.313214 DT.75149867 DT.95159095 DT.100017699 DT.100749870 DT.97858213 DT.121124256 DT.91906443

DT.100702678 DT.121124298 DT.95302000 DT.99993593

Selected AceView cDNA sequences (see all 61):

BM459038 L32867 BC031081 CA418404 X77922 CR623725 L43494 D26360

BX104473 BC046158 NM_003034 BQ425160 BU176840 AI051537 BI550329 AI291051

AA757329 BC039019 AI804052 BM451235 BX092630 BX349049 AU126278 BI460219

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ST8SIA1 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	·	7d
SP1:							-				-		-
SP2:							-				-		-		-
SP3:
SP4:															-
SP5:

ECgene alternative splicing isoforms for ST8SIA1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ST8SIA1 expression in normal human tissues (normalized intensities) ST8SIA1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TCTTTTTCTT

About this image

ST8SIA1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 9) fully expand


Brain (Nervous System) fully expand to see all 3 entries
Choroid Plexus Progenitor Cells Choroid Plexus
Cerebral Cortex

Blood (Cardiovascular System) fully expand to see all 2 entries
Common Dendritic Cell Precursors Hematopoietic Bone Marrow

Bone (Muscoskeletal System)
Bone Marrow

Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast

Ovary (Reproductive System)
Oviduct

ST8SIA1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ST8SIA1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.408614

UniProtKB/Swiss-Prot: SIA8A_HUMAN, Q92185

Tissue specificity: Strongly expressed in melanoma cell lines, adult and fetal brain and to a lesser extent in

adult and fetal lung

Custom PCR Arrays for ST8SIA1

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		QuantiFast Probe-based Assays in human, mouse, rat ST8SIA1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST8SIA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ST8SIA1 gene from Selected species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	St8sia1^{1 , 5}	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 less^{1, 5}	87.42(n)¹ 91.83(a)¹		6 (74.78 cM)⁵ 20449¹ NM_011374.2¹ NP_035504.2¹ 142821545⁵
chicken (Gallus gallus)	Aves	ST8SIA1¹	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 less	79.57(n) 82.11(a)		395860 NM_205008.1 NP_990339.1
lizard (Anolis carolinensis)	Reptilia	ST8SIA1⁶	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltra...	81(a)	1 ↔ 1	5(6632857-6705670)
African clawed frog (Xenopus laevis)	Amphibia	LOC398735²	GD3 synthase short isoform	75.43(n)		AY272057.1
zebrafish (Danio rerio)	Actinopterygii	LOC100333872¹	alpha-N-acetylneuraminide alpha-2,8-sialyltransferase-like less	66.46(n) 65.11(a)		100333872 XM_002661388.3 XP_002661434.1

ENSEMBL Gene Tree for ST8SIA1 (if available)
TreeFam Gene Tree for ST8SIA1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ST8SIA1 gene

ST8SIA5² ST8SIA6² ST8SIA3² ST8SIA2² ST8SIA4²

8 SIMAP similar genes for ST8SIA1 using alignment to 7 protein entries: SIA8A_HUMAN (see all proteins):

SIA8F ST8SIA6 ST8Sia VI ST8SIA5 ST3GAL1 ST8SIA3

ST8SIA2 ST8SIA4

ST8SIA1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143007136^1,2	C	--	22345899(+)	`AGACT-/AAAAGG`	1	--	ds500¹		0	--	--	--	--
rs151338714^1,2		--	22345909(+)	`GCACAC/TTTGGG`	1	--	ds500¹		0	--	--	--	--
rs56714418^1,2	F	--	22346208(+)	`ATGACT/GTTTCA`	1	--	ds500¹		1		EA	120
rs139446009^1,2		--	22346254(+)	`ATACAA/TAACAA`	1	--	ds500¹		0	--	--	--	--
rs144988688^1,2		--	22346260(+)	`AACAAA/GGCAGG`	1	--	ds500¹		0	--	--	--	--
rs115786446^1,2	F	--	22346284(+)	`AGAGCG/ATCACC`	1	--	ds500¹		1		WA	118
rs180922637^1,2		--	22346289(+)	`GTCACC/TCATTT`	1	--	ds500¹		0	--	--	--	--
rs77431665^1,2	C,F	--	22346402(+)	`CTTACC/TGAACC`	1	--	ut3¹		1		EA	120
rs185961370^1,2	C	--	22346423(+)	`CAGCCA/GTAATT`	1	--	ut3¹		0	--	--	--	--
rs111631714^1,2	C,F	--	22346448(+)	`AAAGAA/TAAAGA`	1	--	ut3¹		2		CSA WA	120

HapMap Linkage Disequilibrium report for ST8SIA1 (22216707 - 22466707 bp, first 250kb of ST8SIA1)

Structural Variations
Database of Genomic Variants (DGV) 9 variations for ST8SIA1: About this table

Variant ID	Type	Subtype	PubMed ID
nsv435637	CNV	Deletion	17901297
esv269014	CNV	Insertion	20981092
nsv521274	CNV	Loss	19592680
esv23565	CNV	Loss	19812545
nsv482978	CNV	Loss	15286789
esv33913	CNV	Gain	17666407
essv12236	CNV	CNV	17122850
essv14178	CNV	CNV	17122850
dgv482e1	CNV	Complex	17122850

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ST8SIA1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601123 OMIM disorders: --

15 diseases for ST8SIA1: About MalaCards

fatty liver disease liver disease multiple sclerosis choroiditis

hypoxia tonsillitis melanoma lung cancer

breast cancer endotheliitis thyroiditis leukemia

cerebritis neuronitis prostatitis

ST8SIA1 for disorders About GeneDecksing

Genetic Association Database (GAD): ST8SIA1
Human Genome Epidemiology (HuGE) Navigator: ST8SIA1 (3 documents)

Export disorders for ST8SIA1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ST8SIA1 gene, integrated from 10 sources (see all 44):
(articles sorted by number of sources associating them with ST8SIA1)

Utopia: connect your pdf to the dynamic
world of online information

Variants of ST8SIA1 are associated with risk of developing multiple sclerosis. (PubMed id 18612409)^{1, 4, 9} Husain S....Vitale E. (PLoS ONE 2008)
Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families. (PubMed id 19428123)^{1, 4, 9} Ramagopalan S.V....Ebers G.C. (J. Neuroimmunol. 2009)
Isolation of GD3 synthase gene by expression cloning of GM3 alpha- 2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody. (PubMed id 7937974)^{1, 2, 9} Haraguchi M.... Furukawa K. (Proc. Natl. Acad. Sci. U.S.A. 1994)
Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. (PubMed id 20708005)^{1, 4} Chalasani N....Rotter J.I. (Gastroenterology 2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Expression cloning of a human GT3 synthase. GD3 and GT3 are synthesized by a single enzyme. (PubMed id 8631981)^{1, 2} Nakayama J.... Fukuda M. (J. Biol. Chem. 1996)
Expression cloning of a GM3-specific alpha-2,8-sialyltransferase (GD3 synthase). (PubMed id 8195250)^{1, 2} Sasaki K.... Nishi T. (J. Biol. Chem. 1994)
Expression cloning of a CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase (GD3 synthase) from human melanoma cells. (PubMed id 8058740)^{1, 2} Nara K.... Sanai Y. (Proc. Natl. Acad. Sci. U.S.A. 1994)
Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3- sialyltransferase using lectin resistance selection. (PubMed id 7901202)^{1, 3} Sasaki K.... Hasegawa M. (J. Biol. Chem. 1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6489	HGNC: 10869	AceView: SIAT8A	Ensembl:ENSG00000111728	euGenes: HUgn6489
ECgene: ST8SIA1	Kegg: 6489	H-InvDB: ST8SIA1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ST8SIA1	Pharmacogenomics, SNPs, Pathways
GGDB	http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST8SIA1
Functional Glycomics Gateway - GTase	http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_636

Intellectual Property for ST8SIA1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ST8SIA1 gene:
Search GeneIP for patents involving ST8SIA1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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ST8SIA1 Gene

ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase...

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ST8SIA1 (Gene Symbol)
ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 1
SIAT8
SIAT8A
Sialyltransferase 8 (Alpha-N-Acetylneuraminate: Alpha-2,8-Sialytransferase, GD3 Synthase) A
Alpha-2,8-Sialyltransferase 8A
Ganglioside GD3 Synthase
Ganglioside GT3 Synthase
Sialyltransferase St8Sia I
SIAT8-A
ST8SiaI
EC 2.4.99.8
ST8Sia I
GD3S
Alpha-N-Acetylneuraminide Alpha-2,8-Sialyltransferase
Disialoganglioside (GD3) Synthase
Ganglioside-Specific Alpha-2,8-Polysialyltransferase
Sialyltransferase 8A (Alpha-N-Acetylneuraminate: Alpha-2,8-Sialyltransferase, GD3 Synthase)
Sialytransferase St8Sia I
Sialyltransferase 8A

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ST8SIA1 Gene

ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase...

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