Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ST8SIA1 Gene

Aliases for ST8SIA1 Gene

  • ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 1 2 3
  • SIAT8 3 4 6
  • Sialyltransferase 8 (Alpha-N-Acetylneuraminate: Alpha-2,8-Sialytransferase, GD3 Synthase) A 2 3
  • Alpha-2,8-Sialyltransferase 8A 3 4
  • Sialyltransferase St8Sia I 3 4
  • Ganglioside GD3 Synthase 3 4
  • Ganglioside GT3 Synthase 3 4
  • EC 4 63
  • SIAT8-A 3 4
  • ST8SiaI 3 4
  • SIAT8A 3 4
  • Sialyltransferase 8A (Alpha-N-Acetylneuraminate: Alpha-2,8-Sialyltransferase, GD3 Synthase) 3
  • Alpha-N-Acetylneuraminide Alpha-2,8-Sialyltransferase 3
  • Ganglioside-Specific Alpha-2,8-Polysialyltransferase 3
  • Disialoganglioside (GD3) Synthase 3
  • Sialytransferase St8Sia I 3
  • Sialyltransferase 8A 4
  • ST8Sia I 2
  • GD3S 3

External Ids for ST8SIA1 Gene

Previous HGNC Symbols for ST8SIA1 Gene

  • SIAT8
  • SIAT8A

Previous GeneCards Identifiers for ST8SIA1 Gene

  • GC12M022246
  • GC12M022119

Summaries for ST8SIA1 Gene

Entrez Gene Summary for ST8SIA1 Gene

  • Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2015]

GeneCards Summary for ST8SIA1 Gene

ST8SIA1 (ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosphingolipid biosynthesis - ganglio series. GO annotations related to this gene include sialyltransferase activity and alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. An important paralog of this gene is ST8SIA6.

UniProtKB/Swiss-Prot for ST8SIA1 Gene

  • Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid.

Gene Wiki entry for ST8SIA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST8SIA1 Gene

Genomics for ST8SIA1 Gene

Regulatory Elements for ST8SIA1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ST8SIA1 Gene

22,063,773 bp from pter
22,437,041 bp from pter
373,269 bases
Minus strand

Genomic View for ST8SIA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ST8SIA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST8SIA1 Gene

Proteins for ST8SIA1 Gene

  • Protein details for ST8SIA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
    Protein Accession:
    Secondary Accessions:
    • A8K4H6
    • Q17RL0
    • Q6PZN5
    • Q93064

    Protein attributes for ST8SIA1 Gene

    356 amino acids
    Molecular mass:
    40519 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC37586.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA54891.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ST8SIA1 Gene


neXtProt entry for ST8SIA1 Gene

Proteomics data for ST8SIA1 Gene at MOPED

Post-translational modifications for ST8SIA1 Gene

  • Glycosylation at Asn71, Asn119, Asn214, and Asn245
  • Modification sites at PhosphoSitePlus

Other Protein References for ST8SIA1 Gene

Antibody Products

  • R&D Systems Antibodies for ST8SIA1 ("ST8 alpha-2,8-Sialyltransferase 8A/ST8SIA1")

Protein Products

Domains for ST8SIA1 Gene

Gene Families for ST8SIA1 Gene

  • ST3G :Sialyltransferases

Protein Domains for ST8SIA1 Gene

Suggested Antigen Peptide Sequences for ST8SIA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q92185
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST8SIA1: view

Function for ST8SIA1 Gene

Molecular function for ST8SIA1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R.
UniProtKB/Swiss-Prot Function:
Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid.

Enzyme Numbers (IUBMB) for ST8SIA1 Gene

Gene Ontology (GO) - Molecular Function for ST8SIA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IEA --
GO:0008373 sialyltransferase activity TAS 8195250
genes like me logo Genes that share ontologies with ST8SIA1: view
genes like me logo Genes that share phenotypes with ST8SIA1: view

Animal Models for ST8SIA1 Gene

MGI Knock Outs for ST8SIA1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ST8SIA1

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for ST8SIA1 Gene

Localization for ST8SIA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST8SIA1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for ST8SIA1 Gene COMPARTMENTS Subcellular localization image for ST8SIA1 gene
Compartment Confidence
golgi apparatus 5
mitochondrion 2
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ST8SIA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane TAS 8195250
GO:0030173 integral component of Golgi membrane IEA --
genes like me logo Genes that share ontologies with ST8SIA1: view

Pathways for ST8SIA1 Gene

genes like me logo Genes that share pathways with ST8SIA1: view

UniProtKB/Swiss-Prot Q92185-SIA8A_HUMAN

  • Pathway: Lipid metabolism; sphingolipid metabolism
  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for ST8SIA1 Gene

Gene Ontology (GO) - Biological Process for ST8SIA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 8195250
GO:0006486 protein glycosylation --
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006688 glycosphingolipid biosynthetic process TAS 8195250
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with ST8SIA1: view

Compounds for ST8SIA1 Gene

(86) HMDB Compounds for ST8SIA1 Gene

Compound Synonyms Cas Number PubMed IDs
Cytidine monophosphate
  • 5'-CMP
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-acetylneuraminate
Ganglioside GD3 (d18:1/12:0)
  • GD3
Ganglioside GD3 (d18:1/16:0)
  • GD3
Ganglioside GD3 (d18:1/18:0)
  • GD3

(2) Novoseek inferred chemical compound relationships for ST8SIA1 Gene

Compound -log(P) Hits PubMed IDs
ganglioside 76.1 5
sialic acid 45.6 1
genes like me logo Genes that share compounds with ST8SIA1: view

Transcripts for ST8SIA1 Gene

Unigene Clusters for ST8SIA1 Gene

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ST8SIA1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST8SIA1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - -
SP2: - - - -
SP4: -

Relevant External Links for ST8SIA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ST8SIA1 Gene

mRNA expression in normal human tissues for ST8SIA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST8SIA1 Gene

This gene is overexpressed in Brain - Cerebellum (4.0) and Brain - Cerebellar Hemisphere (4.0).

Protein differential expression in normal tissues for ST8SIA1 Gene

This gene is overexpressed in Plasma (42.0) and Heart (27.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ST8SIA1 Gene

SOURCE GeneReport for Unigene cluster for ST8SIA1 Gene Hs.408614

mRNA Expression by UniProt/SwissProt for ST8SIA1 Gene

Tissue specificity: Strongly expressed in melanoma cell lines, adult and fetal brain and to a lesser extent in adult and fetal lung.
genes like me logo Genes that share expressions with ST8SIA1: view

Expression partners for ST8SIA1 Gene

In Situ Assay Products

Orthologs for ST8SIA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST8SIA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ST8SIA1 35
  • 92.79 (n)
  • 96.07 (a)
ST8SIA1 36
  • 96 (a)
(Canis familiaris)
Mammalia ST8SIA1 35
  • 94.01 (n)
  • 98.31 (a)
ST8SIA1 36
  • 98 (a)
(Mus musculus)
Mammalia St8sia1 35
  • 87.42 (n)
  • 91.83 (a)
St8sia1 16
St8sia1 36
  • 92 (a)
(Pan troglodytes)
Mammalia ST8SIA1 35
  • 99.44 (n)
  • 99.44 (a)
ST8SIA1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia St8sia1 35
  • 87.04 (n)
  • 91.27 (a)
(Monodelphis domestica)
Mammalia ST8SIA1 36
  • 72 (a)
(Gallus gallus)
Aves ST8SIA1 35
  • 79.57 (n)
  • 82.11 (a)
ST8SIA1 36
  • 82 (a)
(Anolis carolinensis)
Reptilia ST8SIA1 36
  • 81 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398735 35
(Danio rerio)
Actinopterygii LOC100333872 35
  • 66.46 (n)
  • 65.11 (a)
st8sia1 36
  • 62 (a)
st8sia1 36
  • 62 (a)
Species with no ortholog for ST8SIA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST8SIA1 Gene

Gene Tree for ST8SIA1 (if available)
Gene Tree for ST8SIA1 (if available)

Paralogs for ST8SIA1 Gene

Paralogs for ST8SIA1 Gene

Selected SIMAP similar genes for ST8SIA1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ST8SIA1: view

Variants for ST8SIA1 Gene

Sequence variations from dbSNP and Humsavar for ST8SIA1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs704219 -- 22,201,987(-) AAAAT(C/T)TATAA synonymous-codon, reference
rs722248 -- 22,214,139(-) AAGTG(C/T)GATAA intron-variant
rs734554 -- 22,297,679(+) ATCCA(C/G)TTTCC intron-variant
rs734555 -- 22,297,748(+) ATTAT(A/G)AAATA intron-variant
rs741368 -- 22,272,866(+) TGACT(G/T)AGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST8SIA1 Gene

Variant ID Type Subtype PubMed ID
essv14178 CNV CNV 17122850
dgv482e1 CNV Complex 17122850
nsv482978 CNV Loss 15286789
nsv521274 CNV Loss 19592680
esv33913 CNV Gain 17666407
esv269014 CNV Insertion 20981092
nsv435637 CNV Deletion 17901297
esv23565 CNV Loss 19812545
essv12236 CNV CNV 17122850

Relevant External Links for ST8SIA1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST8SIA1 Gene

Disorders for ST8SIA1 Gene

Relevant External Links for ST8SIA1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for ST8SIA1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ST8SIA1 Gene

Publications for ST8SIA1 Gene

  1. Isolation of GD3 synthase gene by expression cloning of GM3 alpha- 2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody. (PMID: 7937974) Haraguchi M. … Furukawa K. (Proc. Natl. Acad. Sci. U.S.A. 1994) 3 4 23
  2. Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families. (PMID: 19428123) Ramagopalan S.V. … Ebers G.C. (J. Neuroimmunol. 2009) 3 23 48
  3. Variants of ST8SIA1 are associated with risk of developing multiple sclerosis. (PMID: 18612409) Husain S. … Vitale E. (PLoS ONE 2008) 3 23 48
  4. Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer. (PMID: 19125296) RuckhAoberle E. … Kaufmann M. (J. Cancer Res. Clin. Oncol. 2009) 3 23
  5. Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3- sialyltransferase using lectin resistance selection. (PMID: 7901202) Sasaki K. … Hasegawa M. (J. Biol. Chem. 1993) 2 3

Products for ST8SIA1 Gene

Sources for ST8SIA1 Gene

Back to Top