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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ST8SIA1 Gene

protein-coding   GIFtS: 57
GCID: GC12M022119

ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase...

(Previous names: sialyltransferase 8 (alpha-N-acetylneuraminate: alpha-2,8-sialytransferase,...)
(Previous symbols: SIAT8, SIAT8A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 11 2     EC 2.4.99.83 8
SIAT81 2 3 5     ST8Sia I1
SIAT8A1 2 3     GD3S2
Sialyltransferase 8 (Alpha-N-Acetylneuraminate:
Alpha-2,8-Sialytransferase, GD3 Synthase) A1 2
     Alpha-N-Acetylneuraminide Alpha-2,8-Sialyltransferase2
Alpha-2,8-Sialyltransferase 8A2 3     Disialoganglioside (GD3) Synthase2
Ganglioside GD3 Synthase2 3     Ganglioside-Specific Alpha-2,8-Polysialyltransferase2
Ganglioside GT3 Synthase2 3     Sialyltransferase 8A (Alpha-N-Acetylneuraminate:
Alpha-2,8-Sialyltransferase, GD3 Synthase)2
Sialyltransferase St8Sia I2 3     Sialytransferase St8Sia I2
SIAT8-A2 3     Sialyltransferase 8A3
ST8SiaI2 3     

External Ids:    HGNC: 108691   Entrez Gene: 64892   Ensembl: ENSG000001117287   OMIM: 6011235   UniProtKB: Q921853   

Export aliases for ST8SIA1 gene to outside databases

Previous GC identifer: GC12M022246


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ST8SIA1 Gene:
Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be
important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II
membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides
GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase
family 29. (provided by RefSeq, Jul 2008)

GeneCards Summary for ST8SIA1 Gene: 
ST8SIA1 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1) is a protein-coding gene. Diseases associated with ST8SIA1 include fatty liver disease, and liver disease, and among its related super-pathways are Glycosphingolipid biosynthesis - ganglio series and Metabolism. GO annotations related to this gene include alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity and sialyltransferase activity. An important paralog of this gene is ST8SIA5.

UniProtKB/Swiss-Prot: SIA8A_HUMAN, Q92185
Function: Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex
glycosphinglolipds that contain one or more residues of sialic acid

Gene Wiki entry for ST8SIA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ST8SIA1 gene promoter:
         GR   HOXA9B   HOXA9   CUTL1   Gfi-1   Meis-1b   C/EBPalpha   RORalpha1   GR-alpha   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidST8SIA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ST8SIA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST8SIA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.1-p11.2   Ensembl cytogenetic band:  12p12.1   HGNC cytogenetic band: 12p12.1-p11.2

ST8SIA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST8SIA1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M022119:  view genomic region     (about GC identifiers)

Start:
22,216,707 bp from pter      End:
22,589,975 bp from pter
Size:
373,269 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SIA8A_HUMAN, Q92185 (See protein sequence)
Recommended Name: Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase  
Size: 356 amino acids; 40519 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
Sequence caution: Sequence=AAC37586.1; Type=Erroneous initiation; Sequence=CAA54891.1; Type=Erroneous initiation;
Secondary accessions: A8K4H6 Q17RL0 Q6PZN5 Q93064
Alternative splicing: 2 isoforms:  Q92185-1   Q92185-2   

Explore the universe of human proteins at neXtProt for ST8SIA1: NX_Q92185

Explore proteomics data for ST8SIA1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92185

  • 4/6 DME Specific Peptides for ST8SIA1 (Q92185) (see all 6)
     WPFSVNM  PSLRVYYTL  GKFWKSRGIH  HAMPEEFLQLW 

    ST8SIA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ST8SIA1 Protein Expression
    REFSEQ proteins: NP_003025.1  
    ENSEMBL proteins: 
     ENSP00000379353   ENSP00000261197   ENSP00000441707   ENSP00000444999   ENSP00000440292  
     ENSP00000384467   ENSP00000370832   ENSP00000446363  

    Human Recombinant Protein Products for ST8SIA1: 
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    Novus Biologicals ST8SIA1 Proteins
    Novus Biologicals ST8SIA1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus ----
    GO:0016021integral to membrane TAS8195250
    GO:0030173integral to Golgi membrane IEA--

    ST8SIA1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ST3G: Sialyltransferases

    2 InterPro protein domains:
     IPR001675 Glyco_trans_29
     IPR012163 Sialyl_trans

    Graphical View of Domain Structure for InterPro Entry Q92185

    ProtoNet protein and cluster: Q92185

    1 Blocks protein domain: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIA8A_HUMAN, Q92185
    Similarity: Belongs to the glycosyltransferase 29 family


    ST8SIA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIA8A_HUMAN, Q92185
    Function: Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex
    glycosphinglolipds that contain one or more residues of sialic acid
    Catalytic activity: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP +
    alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R

         Enzyme Number (IUBMB): EC 2.4.99.81 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003828alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IEA--
    GO:0008373sialyltransferase activity TAS8195250
    GO:0016757transferase activity, transferring glycosyl groups ----
         
    ST8SIA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ST8SIA1:
     Increased G2M DNA content 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for St8sia1):
     behavior/neurological  cellular  hematopoietic system  immune system  mortality/aging 
     nervous system  normal  reproductive system  respiratory system 

    ST8SIA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out St8sia1tm1Kfk for ST8SIA1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ST8SIA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ST8SIA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ST8SIA1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ST8SIA1 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidST8SIA1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST8SIA1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ST8SIA1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ganglio Sphingolipid Metabolism
    Glycosphingolipid biosynthesis - ganglio series0.53
    Ganglio Sphingolipid Metabolism0.53
    2Metabolism
    Metabolic pathways0.40
    3Glycosphingolipid biosynthesis - lacto and neolacto series
    Glycosphingolipid biosynthesis - lacto and neolacto series
    4Glycosphingolipid biosynthesis - globo series
    Glycosphingolipid biosynthesis - globo series

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ST8SIA1
        Ganglio Sphingolipid Metabolism



    4         Kegg Pathways  (Kegg details for ST8SIA1):
        Glycosphingolipid biosynthesis - lacto and neolacto series
    Glycosphingolipid biosynthesis - globo series
    Glycosphingolipid biosynthesis - ganglio series
    Metabolic pathways

    UniProtKB/Swiss-Prot: SIA8A_HUMAN, Q92185
    Pathway: Protein modification; protein glycosylation
    Pathway: Lipid metabolism; sphingolipid metabolism


    ST8SIA1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ST8SIA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/14 Interacting proteins for ST8SIA1 (ENSP000003793534) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    B4GALNT1ENSP000003415624STRING: ENSP00000341562
    FUT3ENSP000003056034STRING: ENSP00000305603
    FUT4ENSP000003516024STRING: ENSP00000351602
    FUT5ENSP000002526754STRING: ENSP00000252675
    FUT6ENSP000002869554STRING: ENSP00000286955
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS8195250
    GO:0006486protein glycosylation IEA--
    GO:0006688glycosphingolipid biosynthetic process TAS8195250
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0034605cellular response to heat IEA--

    ST8SIA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ST8SIA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ST8SIA1 (SIA8A)

    10/86 HMDB Compounds for ST8SIA1 (see all 86)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Ganglioside GM1 (d18:0/12:0) --12486725
    Ganglioside GM1 (d18:0/14:0) --12486725
    Ganglioside GM1 (d18:0/16:0) --12486725
    Ganglioside GM1 (d18:0/18:0) --12486725
    Ganglioside GM1 (d18:0/18:1(11Z)) --12486725
    Ganglioside GM1 (d18:0/18:1(9Z)) --12486725
    Ganglioside GM1 (d18:0/20:0) --12486725
    Ganglioside GM1 (d18:0/22:0) --12486725
    Ganglioside GM1 (d18:0/22:1(13Z)) --12486725
    Ganglioside GM1 (d18:0/23:0) --12486725

    2 Novoseek inferred chemical compound relationships for ST8SIA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ganglioside 76.1 6 19125296 (2), 7937974 (1), 18058224 (1), 19428123 (1)
    sialic acid 45.6 1 16014806 (1)

    Search CenterWatch for drugs/clinical trials and news about ST8SIA1 / SIA8A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ST8SIA1 gene: 
    NM_003034.3  

    Unigene Cluster for ST8SIA1:

    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
    Hs.408614  [show with all ESTs]
    Unigene Representative Sequence: NM_003034
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536535 ENST00000544732 ENST00000537795 ENST00000545524 ENST00000396037(uc001rfo.4)
    ENST00000261197(uc009zix.3) ENST00000545494 ENST00000508924 ENST00000540824
    ENST00000538256 ENST00000541868 ENST00000404299 ENST00000536558 ENST00000381424
    ENST00000545185 ENST00000539510
    miRNA
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    Additional mRNA sequence: 

    AF088002.1 AK290941.1 AK297310.1 AK315340.1 AY569975.1 BC031081.1 BC046158.1 BC117285.1 
    BC126162.1 D26360.1 EU041716.1 L32867.1 L43494.1 X77922.1 

    12 DOTS entries:

    DT.313214  DT.75149867  DT.95159095  DT.100017699  DT.100749870  DT.97858213  DT.121124256  DT.91906443 
    DT.100702678  DT.121124298  DT.95302000  DT.99993593 

    24/61 AceView cDNA sequences (see all 61):

    NM_003034 CA418404 BM459038 BQ425160 L32867 BX104473 L43494 CR623725 
    BC031081 BC046158 D26360 X77922 AI090916 BX349049 AI291051 AU132392 
    BX092630 AI051537 AF088002 N95342 BI460219 BX340094 BC039019 BU176840 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ST8SIA1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:                    -           -     -                                       
    SP2:                    -           -     -     -                                 
    SP3:                                                                              
    SP4:                                            -                                 
    SP5:                                                                              


    ECgene alternative splicing isoforms for ST8SIA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ST8SIA1 expression in normal human tissues (normalized intensities)      ST8SIA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTTTCTT
    ST8SIA1 Expression
    About this image


    ST8SIA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Cerebral Cortex
             postcentral gyrus   
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             cd4+ cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Epithelium
             oral mucosa ; squamous epithelial cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   

    See ST8SIA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ST8SIA1

    SOURCE GeneReport for Unigene cluster: Hs.408614

    UniProtKB/Swiss-Prot: SIA8A_HUMAN, Q92185
    Tissue specificity: Strongly expressed in melanoma cell lines, adult and fetal brain and to a lesser extent in
    adult and fetal lung

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ST8SIA1 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St8sia11 , 5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more1, 5 87.32(n)1
    91.83(a)1
      6 (74.78 cM)5
    204491  NM_011374.21  NP_035504.21 
     1428215455 
    chicken
    (Gallus gallus)
    Aves ST8SIA11 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase more 79.57(n)
    82.11(a)
      395860  NM_205008.1  NP_990339.1 
    lizard
    (Anolis carolinensis)
    Reptilia ST8SIA16
    Uncharacterized protein
    81(a)
    1 ↔ 1
    5(6632857-6705670)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3987352 GD3 synthase short isoform 75.43(n)    AY272057.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003338721 alpha-N-acetylneuraminide alpha-2,8-sialyltransferase-like 67.09(n)
    66.35(a)
      100333872  XM_002661388.2  XP_002661434.1 


    ENSEMBL Gene Tree for ST8SIA1 (if available)
    TreeFam Gene Tree for ST8SIA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ST8SIA1 gene
    ST8SIA52  ST8SIA62  ST8SIA32  ST8SIA22  ST8SIA42  
    8 SIMAP similar genes for ST8SIA1 using alignment to 7 protein entries:     SIA8A_HUMAN (see all proteins):
    SIA8F    ST8SIA6    ST8Sia VI    ST8SIA5    ST3GAL1    ST8SIA3
    ST8SIA2    ST8SIA4

    ST8SIA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2765 SNPs in ST8SIA1 are shown (see all 2765)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1430071361,2
    C--22345899(+) AGACT-/AAAAGG 1 -- ds50010--------
    rs1513387141,2
    --22345909(+) GCACAC/TTTGGG 1 -- ds50010--------
    rs567144181,2
    F--22346208(+) ATGACT/GTTTCA 1 -- ds50011Minor allele frequency- G:0.02EA 120
    rs1394460091,2
    --22346254(+) ATACAA/TAACAA 1 -- ds50010--------
    rs1449886881,2
    --22346260(+) AACAAA/GGCAGG 1 -- ds50010--------
    rs1157864461,2
    F--22346284(+) AGAGCG/ATCACC 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1809226371,2
    --22346289(+) GTCACC/TCATTT 1 -- ds50010--------
    rs774316651,2
    C,F--22346402(+) CTTACC/TGAACC 1 -- ut311Minor allele frequency- T:0.05EA 120
    rs1859613701,2
    C--22346423(+) CAGCCA/GTAATT 1 -- ut310--------
    rs1116317141,2
    C,F--22346448(+) AAAGAA/TAAAGA 1 -- ut312Minor allele frequency- T:0.02CSA WA 120

    HapMap Linkage Disequilibrium report for ST8SIA1 (22216707 - 22466707 bp, first 250kb of ST8SIA1)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ST8SIA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv435637CNV Deletion17901297
    esv269014CNV Insertion20981092
    nsv521274CNV Loss19592680
    esv23565CNV Loss19812545
    nsv482978CNV Loss15286789
    esv33913CNV Gain17666407
    essv12236CNV CNV17122850
    essv14178CNV CNV17122850
    dgv482e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601123    OMIM disorders: --

    11 diseases for ST8SIA1:    About MalaCards
    fatty liver disease    liver disease    multiple sclerosis    glioblastoma
    hypoxia    melanoma    lung cancer    breast cancer
    endotheliitis    leukemia    neuronitis


    ST8SIA1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ST8SIA1
    Human Genome Epidemiology (HuGE) Navigator: ST8SIA1 (3 documents)

    Export disorders for ST8SIA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ST8SIA1 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with ST8SIA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variants of ST8SIA1 are associated with risk of developing multiple sclerosis. (PubMed id 18612409)1, 4, 9 Husain S....Vitale E. (2008)
    2. Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families. (PubMed id 19428123)1, 4, 9 Ramagopalan S.V....Ebers G.C. (2009)
    3. Isolation of GD3 synthase gene by expression cloning of GM3 alpha- 2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody. (PubMed id 7937974)1, 2, 9 Haraguchi M.... Furukawa K. (1994)
    4. Genome-wide association study identifies variants ass ociated with histologic features of nonalcoholic Fatty liver disease. (PubMed id 20708005)1, 4 Chalasani N....Rotter J.I. (2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Expression cloning of a human GT3 synthase. GD3 and GT3 are synthesized by a single enzyme. (PubMed id 8631981)1, 2 Nakayama J.... Fukuda M. (1996)
    8. Expression cloning of a GM3-specific alpha-2,8-sialyltransferase (GD3 synthase). (PubMed id 8195250)1, 2 Sasaki K.... Nishi T. (1994)
    9. Expression cloning of a CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase (GD3 synthase) from human melanoma cells. (PubMed id 8058740)1, 2 Nara K.... Sanai Y. (1994)
    10. Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3- sialyltransferase using lectin resistance selection. (PubMed id 7901202)1, 3 Sasaki K.... Hasegawa M. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6489 HGNC: 10869 AceView: SIAT8A Ensembl:ENSG00000111728 euGenes: HUgn6489
    ECgene: ST8SIA1 Kegg: 6489 H-InvDB: ST8SIA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ST8SIA1 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST8SIA1
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_636

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ST8SIA1 gene:
    Search GeneIP for patents involving ST8SIA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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