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Aliases for ST7L Gene

Aliases for ST7L Gene

  • Suppression Of Tumorigenicity 7 Like 2 3 5
  • ST7-Related Protein 3 4
  • ST7R 3 4
  • Tumor Suppressor ST7 Like 3
  • FAM4B 3
  • STLR 3

External Ids for ST7L Gene

Previous GeneCards Identifiers for ST7L Gene

  • GC01M113483
  • GC01M111938
  • GC01M112168
  • GC01M112364
  • GC01M112778
  • GC01M113066
  • GC01M110925

Summaries for ST7L Gene

Entrez Gene Summary for ST7L Gene

  • This gene was identified by its similarity to the ST7 tumor suppressor gene found in the chromosome 7q31 region. This gene is clustered in a tail-to-tail manner with the WNT2B gene in a chromosomal region known to be deleted and rearranged in a variety of cancers. Several transcript variants encoding many different isoforms have been described, but some have not been fully characterized. [provided by RefSeq, Feb 2011]

GeneCards Summary for ST7L Gene

ST7L (Suppression Of Tumorigenicity 7 Like) is a Protein Coding gene. An important paralog of this gene is ST7-OT3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST7L Gene

Genomics for ST7L Gene

Regulatory Elements for ST7L Gene

Enhancers for ST7L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ST7L on UCSC Golden Path with GeneCards custom track

Promoters for ST7L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ST7L on UCSC Golden Path with GeneCards custom track

Genomic Location for ST7L Gene

Chromosome:
1
Start:
112,517,804 bp from pter
End:
112,620,838 bp from pter
Size:
103,035 bases
Orientation:
Minus strand

Genomic View for ST7L Gene

Genes around ST7L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST7L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST7L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST7L Gene

Proteins for ST7L Gene

  • Protein details for ST7L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDW4-ST7L_HUMAN
    Recommended name:
    Suppressor of tumorigenicity 7 protein-like
    Protein Accession:
    Q8TDW4
    Secondary Accessions:
    • A8K4S7
    • Q49AH6
    • Q5TEI4
    • Q5U5K6
    • Q6N067
    • Q7Z2Z0
    • Q7Z3C2
    • Q8N7P8
    • Q8TDW1
    • Q8TDW2
    • Q8TDW3
    • Q9NXF3

    Protein attributes for ST7L Gene

    Size:
    575 amino acids
    Molecular mass:
    64779 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91060.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAE45803.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ST7L Gene

neXtProt entry for ST7L Gene

Proteomics data for ST7L Gene at MOPED

Post-translational modifications for ST7L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ST7L Gene

Domains & Families for ST7L Gene

Protein Domains for ST7L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8TDW4

UniProtKB/Swiss-Prot:

ST7L_HUMAN :
  • Belongs to the ST7 family.
Family:
  • Belongs to the ST7 family.
genes like me logo Genes that share domains with ST7L: view

No data available for Gene Families for ST7L Gene

Function for ST7L Gene

genes like me logo Genes that share phenotypes with ST7L: view

Animal Model Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ST7L Gene

Localization for ST7L Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST7L Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST7L Gene COMPARTMENTS Subcellular localization image for ST7L gene
Compartment Confidence
peroxisome 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
nucleus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for ST7L Gene

Pathways & Interactions for ST7L Gene

SuperPathways for ST7L Gene

No Data Available

Interacting Proteins for ST7L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000350734%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000350734 for ST7L Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for ST7L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ST7L Gene

Drugs & Compounds for ST7L Gene

No Compound Related Data Available

Transcripts for ST7L Gene

Unigene Clusters for ST7L Gene

Suppression of tumorigenicity 7 like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ST7L Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - - -
SP13: - - - - - -
SP14: - - - - -
SP15: - - - -
SP16: - - - - - -
SP17:
SP18:

ExUns: 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b · 21c
SP1: - -
SP2: - - -
SP3:
SP4: - - - -
SP5: - - - - -
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for ST7L Gene

GeneLoc Exon Structure for
ST7L
ECgene alternative splicing isoforms for
ST7L

Expression for ST7L Gene

mRNA expression in normal human tissues for ST7L Gene

Protein differential expression in normal tissues from HIPED for ST7L Gene

This gene is overexpressed in Heart (48.1) and Tlymphocyte (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ST7L Gene



SOURCE GeneReport for Unigene cluster for ST7L Gene Hs.201921

genes like me logo Genes that share expression patterns with ST7L: view

Protein tissue co-expression partners for ST7L Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ST7L Gene

Orthologs for ST7L Gene

This gene was present in the common ancestor of animals.

Orthologs for ST7L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ST7L 35
  • 93.81 (n)
  • 95.77 (a)
ST7L 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ST7L 35
  • 94.8 (n)
  • 97.3 (a)
ST7L 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St7l 35
  • 89.34 (n)
  • 91.36 (a)
St7l 16
St7l 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ST7L 35
  • 99.71 (n)
  • 99.3 (a)
ST7L 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia St7l 35
  • 89.4 (n)
  • 91.54 (a)
oppossum
(Monodelphis domestica)
Mammalia ST7L 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
chicken
(Gallus gallus)
Aves ST7L 35
  • 76.69 (n)
  • 81.73 (a)
ST7L 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST7L 36
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii st7l 36
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3634 37
  • 65 (a)
CG3634 36
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F11A10.5 37
  • 48 (a)
F11A10.5 36
  • 46 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
OneToMany
Species with no ortholog for ST7L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ST7L Gene

ENSEMBL:
Gene Tree for ST7L (if available)
TreeFam:
Gene Tree for ST7L (if available)

Paralogs for ST7L Gene

Paralogs for ST7L Gene

(1) SIMAP similar genes for ST7L Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ST7L: view

Variants for ST7L Gene

Sequence variations from dbSNP and Humsavar for ST7L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6658555 - 112,555,912(+) CTATT(C/T)GTTTC intron-variant, nc-transcript-variant, reference, missense
rs3736764 - 112,555,901(-) AAGGT(A/G)CTCTT intron-variant, nc-transcript-variant, reference, missense
rs12069022 - 112,526,029(+) TCAAA(C/T)CTAGG intron-variant, nc-transcript-variant, reference, missense
rs367284 -- 112,594,406(-) ACTTT(C/T)TTTCC intron-variant
rs368949 -- 112,554,344(-) gttta(G/T)tggcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST7L Gene

Variant ID Type Subtype PubMed ID
esv27061 CNV Gain+Loss 19812545
nsv831081 CNV Loss 17160897
essv21692 CNV CNV 17122850

Variation tolerance for ST7L Gene

Residual Variation Intolerance Score: 84.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.68; 82.93% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ST7L Gene

Disorders for ST7L Gene

Relevant External Links for ST7L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ST7L

No disorders were found for ST7L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST7L Gene

Publications for ST7L Gene

  1. Molecular cloning and characterization of ST7R (ST7-like, ST7L) on human chromosome 1p13, a novel gene homologous to tumor suppressor gene ST7 on human chromosome 7q31. (PMID: 12012006) Katoh M. (Int. J. Oncol. 2002) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. MiR-24 regulates the proliferation and invasion of glioma by ST7L via I^-catenin/Tcf-4 signaling. (PMID: 23142218) Chen L. … Kang C. (Cancer Lett. 2013) 3
  4. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. (PMID: 21572416) Kato N. … He J. (Nat. Genet. 2011) 3
  5. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3

Products for ST7L Gene

Sources for ST7L Gene

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