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Aliases for ST7L Gene

Aliases for ST7L Gene

  • Suppression Of Tumorigenicity 7 Like 2 3 5
  • ST7-Related Protein 3 4
  • ST7R 3 4
  • Suppressor Of Tumorigenicity 7 Protein-Like 3
  • Tumor Suppressor ST7 Like 3
  • FAM4B 3
  • STLR 3

External Ids for ST7L Gene

Previous GeneCards Identifiers for ST7L Gene

  • GC01M113483
  • GC01M111938
  • GC01M112168
  • GC01M112364
  • GC01M112778
  • GC01M113066
  • GC01M110925

Summaries for ST7L Gene

Entrez Gene Summary for ST7L Gene

  • This gene was identified by its similarity to the ST7 tumor suppressor gene found in the chromosome 7q31 region. This gene is clustered in a tail-to-tail manner with the WNT2B gene in a chromosomal region known to be deleted and rearranged in a variety of cancers. Several transcript variants encoding many different isoforms have been described, but some have not been fully characterized. [provided by RefSeq, Feb 2011]

GeneCards Summary for ST7L Gene

ST7L (Suppression Of Tumorigenicity 7 Like) is a Protein Coding gene. An important paralog of this gene is ST7-OT3.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST7L Gene

Genomics for ST7L Gene

Regulatory Elements for ST7L Gene

Enhancers for ST7L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G112542 1.4 FANTOM5 Ensembl ENCODE 66.1 +76.4 76384 4.5 TBP PKNOX1 ATF1 ZFP64 BRCA1 RFX5 TCF12 ZNF121 SCRT2 RCOR1 ST7L LOC100421402 DDX20 LOC100996251 CTTNBP2NL CAPZA1 GC01P112527 PIR33611
GH01G112696 1.7 Ensembl ENCODE dbSUPER 34 -81.6 -81615 11.2 MLX CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D ST7L LOC100421402 CAPZA1 LRIG2 RHOC GC01M112698 PIR32287
GH01G112548 0.7 ENCODE 67.2 +71.8 71826 1.5 HLF FEZF1 ZEB2 ZNF843 ARID1B FOSL1 PRDM6 JUND ZBTB33 HNF4A ST7L GC01P112527 PIR33611
GH01G112671 1.1 ENCODE 37.7 -53.2 -53183 4.6 HDGF FOXA2 PKNOX1 CREB3L1 ARNT MLX AGO1 ARID4B SIN3A FEZF1 ST7L CAPZA1 MOV10 GC01P112680
GH01G112531 0.5 ENCODE 71.2 +87.8 87834 2.4 ZNF121 THRAP3 KAT8 ST7L CAPZA1 GC01P112527 PIR33611
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ST7L on UCSC Golden Path with GeneCards custom track

Promoters for ST7L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000011504 1238 3201 HDGF PKNOX1 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2
ENSR00000253615 -1262 201 BCOR HDAC1 PKNOX1 ZBTB40 CHAMP1 ARID3A ELK1 ADNP RELB MAFK

Genomic Location for ST7L Gene

Chromosome:
1
Start:
112,517,804 bp from pter
End:
112,620,838 bp from pter
Size:
103,035 bases
Orientation:
Minus strand

Genomic View for ST7L Gene

Genes around ST7L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST7L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST7L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST7L Gene

Proteins for ST7L Gene

  • Protein details for ST7L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDW4-ST7L_HUMAN
    Recommended name:
    Suppressor of tumorigenicity 7 protein-like
    Protein Accession:
    Q8TDW4
    Secondary Accessions:
    • A8K4S7
    • Q49AH6
    • Q5TEI4
    • Q5U5K6
    • Q6N067
    • Q7Z2Z0
    • Q7Z3C2
    • Q8N7P8
    • Q8TDW1
    • Q8TDW2
    • Q8TDW3
    • Q9NXF3

    Protein attributes for ST7L Gene

    Size:
    575 amino acids
    Molecular mass:
    64779 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91060.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAE45803.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ST7L Gene

neXtProt entry for ST7L Gene

Post-translational modifications for ST7L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ST7L Gene

Domains & Families for ST7L Gene

Protein Domains for ST7L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8TDW4

UniProtKB/Swiss-Prot:

ST7L_HUMAN :
  • Belongs to the ST7 family.
Family:
  • Belongs to the ST7 family.
genes like me logo Genes that share domains with ST7L: view

No data available for Gene Families for ST7L Gene

Function for ST7L Gene

genes like me logo Genes that share phenotypes with ST7L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ST7L Gene

Localization for ST7L Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST7L Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST7L gene
Compartment Confidence
peroxisome 2
plasma membrane 1
extracellular 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ST7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST7L: view

Pathways & Interactions for ST7L Gene

No Data Available

Interacting Proteins for ST7L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000350734%0d%0a9606.ENSP00000304843%0d%0a
Selected Interacting proteins: ENSP00000350734 Q8TDW4-ST7L_HUMAN for ST7L Gene via STRING IID

Gene Ontology (GO) - Biological Process for ST7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030308 negative regulation of cell growth ISS --
genes like me logo Genes that share ontologies with ST7L: view

No data available for Pathways by source and SIGNOR curated interactions for ST7L Gene

Drugs & Compounds for ST7L Gene

No Compound Related Data Available

Transcripts for ST7L Gene

Unigene Clusters for ST7L Gene

Suppression of tumorigenicity 7 like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST7L Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - - -
SP13: - - - - - -
SP14: - - - - -
SP15: - - - -
SP16: - - - - - -
SP17:
SP18:

ExUns: 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b · 21c
SP1: - -
SP2: - - -
SP3:
SP4: - - - -
SP5: - - - - -
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for ST7L Gene

GeneLoc Exon Structure for
ST7L
ECgene alternative splicing isoforms for
ST7L

Expression for ST7L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST7L Gene

Protein differential expression in normal tissues from HIPED for ST7L Gene

This gene is overexpressed in Heart (48.1) and Tlymphocyte (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ST7L Gene



Protein tissue co-expression partners for ST7L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ST7L Gene:

ST7L

SOURCE GeneReport for Unigene cluster for ST7L Gene:

Hs.201921

Evidence on tissue expression from TISSUES for ST7L Gene

  • Nervous system(4.5)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with ST7L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST7L Gene

Orthologs for ST7L Gene

This gene was present in the common ancestor of animals.

Orthologs for ST7L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST7L 34 35
  • 99.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 95 (a)
OneToMany
-- 35
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ST7L 34 35
  • 94.8 (n)
cow
(Bos Taurus)
Mammalia ST7L 34 35
  • 93.81 (n)
rat
(Rattus norvegicus)
Mammalia St7l 34
  • 89.4 (n)
mouse
(Mus musculus)
Mammalia St7l 34 16 35
  • 89.34 (n)
oppossum
(Monodelphis domestica)
Mammalia ST7L 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ST7L 34 35
  • 76.69 (n)
lizard
(Anolis carolinensis)
Reptilia ST7L 35
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii st7l 35
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3634 36 35
  • 65 (a)
worm
(Caenorhabditis elegans)
Secernentea F11A10.5 36 35
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 64 (a)
OneToMany
Species where no ortholog for ST7L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ST7L Gene

ENSEMBL:
Gene Tree for ST7L (if available)
TreeFam:
Gene Tree for ST7L (if available)

Paralogs for ST7L Gene

Paralogs for ST7L Gene

(1) SIMAP similar genes for ST7L Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ST7L: view

Variants for ST7L Gene

Sequence variations from dbSNP and Humsavar for ST7L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000008870 -- 112,534,251(+) GGTAT(A/G)AAATT intron-variant
rs1000039184 -- 112,589,829(+) TAGGC(A/T)GACTT intron-variant
rs1000049579 -- 112,545,784(+) ATCCA(C/T)GGTTC intron-variant
rs1000054693 -- 112,592,612(+) AATGC(A/G)TAATA intron-variant
rs1000086745 -- 112,586,566(+) CAAAA(C/T)ATAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST7L Gene

Variant ID Type Subtype PubMed ID
esv27061 CNV gain+loss 19812545
esv3339804 CNV insertion 20981092
esv3578114 CNV loss 25503493
nsv831081 CNV loss 17160897

Variation tolerance for ST7L Gene

Residual Variation Intolerance Score: 84.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.68; 82.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ST7L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST7L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST7L Gene

Disorders for ST7L Gene

Relevant External Links for ST7L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ST7L

No disorders were found for ST7L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST7L Gene

Publications for ST7L Gene

  1. Molecular cloning and characterization of ST7R (ST7-like, ST7L) on human chromosome 1p13, a novel gene homologous to tumor suppressor gene ST7 on human chromosome 7q31. (PMID: 12012006) Katoh M. (Int. J. Oncol. 2002) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. MiR-24 regulates the proliferation and invasion of glioma by ST7L via I^-catenin/Tcf-4 signaling. (PMID: 23142218) Chen L. … Kang C. (Cancer Lett. 2013) 3 64
  5. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. (PMID: 21572416) Kato N. … He J. (Nat. Genet. 2011) 3 64

Products for ST7L Gene

Sources for ST7L Gene

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