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ST7L Gene

protein-coding   GIFtS: 49
GCID: GC01M113066

Suppression Of Tumorigenicity 7 Like

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Suppression Of Tumorigenicity 7 Like1 2     STLR2
ST7R2 3     Suppressor Of Tumorigenicity 7 Protein-Like2
ST7-Related Protein2 3     Tumor Suppressor ST7 Like2
FAM4B2     

External Ids:    HGNC: 184411   Entrez Gene: 548792   Ensembl: ENSG000000073417   UniProtKB: Q8TDW43   
ORGUL members:         

Export aliases for ST7L gene to outside databases

Previous GC identifers: GC01M113483 GC01M111938 GC01M112168 GC01M112364 GC01M112778 GC01M110925


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ST7L Gene:
This gene was identified by its similarity to the ST7 tumor suppressor gene found in the chromosome 7q31 region.
This gene is clustered in a tail-to-tail manner with the WNT2B gene in a chromosomal region known to be deleted
and rearranged in a variety of cancers. Several transcript variants encoding many different isoforms have been
described, but some have not been fully characterized. (provided by RefSeq, Feb 2011)

GeneCards Summary for ST7L Gene:
ST7L (suppression of tumorigenicity 7 like) is a protein-coding gene. An important paralog of this gene is ST7.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ST7L gene promoter:
         GR   Pax-5   AML1a   GATA-3   GR-beta   STAT5A   POU6F1 (c2)   c-Myb   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ST7L promoter sequence
   Search Chromatin IP Primers for ST7L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST7L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.1

ST7L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST7L gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M113066:  view genomic region     (about GC identifiers)

Start:
113,066,140 bp from pter      End:
113,163,447 bp from pter
Size:
97,308 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ST7L_HUMAN, Q8TDW4 (See protein sequence)
Recommended Name: Suppressor of tumorigenicity 7 protein-like  
Size: 575 amino acids; 64779 Da
Sequence caution: Sequence=BAA91060.1; Type=Erroneous initiation; Sequence=CAE45803.1; Type=Erroneous initiation;
Secondary accessions: A8K4S7 Q49AH6 Q5TEI4 Q5U5K6 Q6N067 Q7Z2Z0 Q7Z3C2 Q8N7P8 Q8TDW1 Q8TDW2
Q8TDW3 Q9NXF3
Alternative splicing: 8 isoforms:  Q8TDW4-1   Q8TDW4-2   Q8TDW4-3   Q8TDW4-4   Q8TDW4-5   Q8TDW4-6   Q8TDW4-7   Q8TDW4-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ST7L: NX_Q8TDW4

Explore proteomics data for ST7L at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys415
  • Modification sites at PhosphoSitePlus

  • See ST7L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_060214.2  NP_620055.1  NP_620056.1  NP_620057.1  

    ENSEMBL proteins: 
     ENSP00000436499   ENSP00000353972   ENSP00000350734   ENSP00000436544   ENSP00000358683  
     ENSP00000417140   ENSP00000345312   ENSP00000358680   ENSP00000413718   ENSP00000358678  
     ENSP00000445499   ENSP00000358682   ENSP00000444021   ENSP00000444088  

    ST7L Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals ST7L Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ST7L

     
    Search eBioscience for Proteins for ST7L 

     
    antibodies-online proteins for ST7L (2 products) 

     
    Search antibodies-online for peptides for ST7L

    ST7L Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Cloud-Clone Corp. Antibodies for ST7L
    Search ThermoFisher Antibodies for ST7L
    LSBio Antibodies in human, mouse, rat for ST7L
    antibodies-online antibodies for ST7L (5 products) 

    ST7L Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ST7L
    Cloud-Clone Corp. CLIAs for ST7L
    Search eBioscience for ELISAs for ST7L 
    antibodies-online kits for ST7L (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007311 ST7

    Graphical View of Domain Structure for InterPro Entry Q8TDW4

    ProtoNet protein and cluster: Q8TDW4

    UniProtKB/Swiss-Prot: ST7L_HUMAN, Q8TDW4
    Similarity: Belongs to the ST7 family


    Find genes that share domains with ST7L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ST7L
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ST7L

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ST7L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ST7L

    miRNA
    Products:
        
    miRTarBase miRNAs that target ST7L:
    hsa-mir-18a-3p (MIRT040824), hsa-mir-24-3p (MIRT007215)

    Block miRNA regulation of human, mouse, rat ST7L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ST7L (see all 20):
    hsa-miR-3678-3p hsa-miR-323-3p hsa-miR-3194-5p hsa-miR-1321 hsa-miR-331-3p hsa-miR-1285 hsa-miR-578 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidST7L 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ST7L
    Predesigned siRNA for gene silencing in human, mouse, rat ST7L

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ST7L

    Clone
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    OriGene clones in human, mouse for ST7L (see all 22)
    OriGene ORF clones in mouse, rat for ST7L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): ST7L (NM_138729)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST7L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST7L

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ST7L
    Browse ESI BIO Cell Lines and PureStem Progenitors for ST7L 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST7L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ST7L_HUMAN, Q8TDW4: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome2
    cytosol1
    endoplasmic reticulum1
    extracellular1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ST7L           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ST7L
    Interactions:

        Search GeneGlobe Interaction Network for ST7L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for ST7L (ENSP000003507344) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HECTD3ENSP000003612454STRING: ENSP00000361245
    PRUNEENSP000002716204STRING: ENSP00000271620
    SRSF11ENSP000003599884STRING: ENSP00000359988
    RHBDF1ENSP000002623164STRING: ENSP00000262316
    --ENSP000003910444STRING: ENSP00000391044
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030308negative regulation of cell growth ISS--

    Find genes that share ontologies with ST7L           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ST7L



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ST7L gene (6 alternative transcripts): 
    NM_017744.4  NM_138727.3  NM_138728.2  NM_138729.3  NM_198327.1  NM_198328.1  

    Unigene Cluster for ST7L:

    Suppression of tumorigenicity 7 like
    Hs.201921  [show with all ESTs]
    Unigene Representative Sequence: NM_017744
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 32):
    ENST00000361846(uc009wgh.3 uc001ecc.3 uc010owg.2 uc010owh.2)
    ENST00000360743 ENST00000358039(uc001ecf.3 uc001ecd.3 uc001ece.3)
    ENST00000490715(uc001ecg.3) ENST00000480988 ENST00000495109 ENST00000498197
    ENST00000477682 ENST00000369669 ENST00000490067(uc009wgi.1 uc010owj.1)
    ENST00000497457 ENST00000343210 ENST00000369666(uc001ech.3) ENST00000463235
    ENST00000418497 ENST00000497235 ENST00000369664 ENST00000466360
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ST7L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ST7L (see all 20):
    hsa-miR-3678-3p hsa-miR-323-3p hsa-miR-3194-5p hsa-miR-1321 hsa-miR-331-3p hsa-miR-1285 hsa-miR-578 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidST7L 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ST7L
    Predesigned siRNA for gene silencing in human, mouse, rat ST7L
    Clone
    Products:
         
    OriGene clones in human, mouse for ST7L (see all 22)
    OriGene ORF clones in mouse, rat for ST7L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): ST7L (NM_138729)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST7L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST7L
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ST7L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ST7L
      QuantiTect SYBR Green Assays in human, mouse, rat ST7L
      QuantiFast Probe-based Assays in human, mouse, rat ST7L

    Additional mRNA sequence: 

    AB081317.1 AB081318.1 AB081319.1 AB081320.1 AK000291.1 AK021719.1 AK095837.1 AK097837.1 
    AK128799.1 AK225307.1 AK291042.1 AK295507.1 AK295955.1 AK301869.1 AK304004.1 AK308727.1 
    BC027898.1 BC037830.1 BC065501.1 BX538338.1 BX640667.1 

    Selected DOTS entries (see all 28):

    DT.100798735  DT.100027422  DT.97795637  DT.100798732  DT.91841979  DT.97773315  DT.100798731  DT.438967 
    DT.100027423  DT.101984893  DT.92001694  DT.97842256  DT.100798730  DT.101984894  DT.308710  DT.65284928 
    DT.95155265  DT.95264492  DT.100878614  DT.121336006  DT.75126551  DT.100769065  DT.121335911  DT.95105707 

    Selected AceView cDNA sequences (see all 139):

    AV651218 AB081319 NM_017744 AI469351 NM_138728 CA487759 AA364497 BQ686101 
    BE336823 BX100009 BU622387 AW959842 NM_138729 CA771013 AA336037 AK097837 
    BX640667 BM563434 BC047392 NM_138727 NM_198328 CD358134 AW002802 NM_198327 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ST7L (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^
    SP1:                          -     -     -     -                             -     -     -     -     -     -     -                                             
    SP2:                                -     -     -                             -     -     -     -     -     -     -     -                                       
    SP3:                                                                          -     -     -     -     -     -     -                                             
    SP4:                                                                          -     -     -     -     -     -     -                                             
    SP5:                                                                          -     -     -     -     -     -     -                       -     -     -     -   

    ExUns: 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b · 21c
    SP1:                                            -           -                     
    SP2:                                            -     -     -                     
    SP3:                                                                              
    SP4:                                -           -     -     -                     
    SP5:  -                       -                 -     -     -                     


    ECgene alternative splicing isoforms for ST7L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ST7L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACCTTGGA
    ST7L Expression
    About this image

    ST7L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ST7L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.201921
        Custom PCR Arrays for ST7L
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ST7L
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    QuantiFast Probe-based Assays in human, mouse, rat ST7L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST7L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ST7L gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St7l1 , 5 suppression of tumorigenicity 7-like1, 5 89.34(n)1
    91.36(a)1
      3 (45.88 cM)5
    2296811  NM_153091.31  NP_694731.11 
     1048645035 
    chicken
    (Gallus gallus)
    Aves ST7L1 suppression of tumorigenicity 7 like 76.69(n)
    81.73(a)
      395331  NM_204622.1  NP_989953.1 
    lizard
    (Anolis carolinensis)
    Reptilia ST7L6
    suppression of tumorigenicity 7 like
    77(a)
    1 ↔ 1
    4(128106153-128163427)
    zebrafish
    (Danio rerio)
    Actinopterygii st7l6
    suppression of tumorigenicity 7 like
    73(a)
    1 ↔ 1
    6(48230714-48258151) ENSDARG00000032603
    fruit fly
    (Drosophila melanogaster)
    Insecta CG36343   -- 65(a)   77E8   --
    worm
    (Caenorhabditis elegans)
    Secernentea F11A10.53   -- 48(a)   IV(12094548-12096591)   --


    ENSEMBL Gene Tree for ST7L (if available)
    TreeFam Gene Tree for ST7L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ST7L gene
    ST72  
    1 SIMAP similar gene for ST7L using alignment to 6 protein entries:     ST7L_HUMAN (see all proteins):
    ST7

    Find genes that share paralogs with ST7L           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ST7L (see all 1820)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1923089061,2
    --113065774(+) CTATAA/CCCTAC 3 -- ds50010--------
    rs1380029571,2
    --113065807(+) TCTCAA/TCCCTG 3 -- ds50010--------
    rs1425569741,2
    --113065853(+) ACTCTA/GTGCTT 3 -- ds50010--------
    rs1150437831,2
    C,F--113065899(+) AAGTTT/CTGCAA 3 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1440582041,2
    C--113065922(+) GGTTA-/AGAAAAGA
    GCAAGCTGTC
    CAGAG
    3 -- ds50010--------
    rs1836911231,2
    --113065937(+) AAGCTC/GTCCAG 3 -- ds50010--------
    rs1459848921,2
    C--113066007(+) ACCACA/GGAGGT 3 -- ds50010--------
    rs1386777381,2
    C--113066602(+) AAATAA/CAATCA 3 -- ut310--------
    rs1118009411,2
    C--113066624(+) TTAAAA/GAAAAA 3 -- ut312Minor allele frequency- G:0.13WA 120
    rs1146459221,2
    F--113066625(+) TAAAAA/CAAAAA 3 -- ut311Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for ST7L (113066140 - 113163447 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ST7L:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831081CNV Loss17160897
    esv27061CNV Gain+Loss19812545
    essv21692CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ST7L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ST7L gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with ST7L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of ST7R (ST7-like, ST7L) on human chromosome 1p13, a novel gene homologous to tumor suppressor gene ST7 on human chromosome 7q31. (PubMed id 12012006)1, 2, 3, 9 Katoh M. (Int. J. Oncol. 2002)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. MiR-24 regulates the proliferation and invasion of glioma by ST7L via I^-catenin/Tcf-4 signaling. (PubMed id 23142218)1 Chen L....Kang C. (Cancer Lett. 2013)
    4. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. (PubMed id 21572416)1 Kato N....He J. (Nat. Genet. 2011)
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    6. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Expression of ST7R (ST7-like, ST7L) in normal tissues and cancer. (PubMed id 12063568)1 Kirikoshi H. and Katoh M. (Int. J. Oncol. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54879 HGNC: 18441 AceView: ST7L Ensembl:ENSG00000007341 euGenes: HUgn54879
    ECgene: ST7L H-InvDB: ST7L

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ST7L Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ST7L Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ST7L gene:
    Search GeneIP for patents involving ST7L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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