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Aliases for ST7-OT3 Gene

Subcategory (RNA class) for ST7-OT3 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for ST7-OT3 Gene

  • ST7 Overlapping Transcript 3 2 3
  • ST7 3 4 5
  • ST7 Overlapping Transcript 3 (Non-Protein Coding) 2 3
  • Suppression Of Tumorigenicity 7 3 5
  • ST7 Overlapping Transcript 3 (Non-Coding RNA) 3
  • Non-Protein Coding RNA 26 2
  • Protein FAM4A1 4
  • Protein HELG 4
  • NCRNA00026 3
  • ST7OT3 3
  • FAM4A1 4
  • HELG 4
  • RAY1 4

External Ids for ST7-OT3 Gene

Previous HGNC Symbols for ST7-OT3 Gene

  • ST7OT3

Previous GeneCards Identifiers for ST7-OT3 Gene

  • GC07P116823
  • GC07P117182
  • GC07P116964

Summaries for ST7-OT3 Gene

GeneCards Summary for ST7-OT3 Gene

ST7-OT3 (ST7 Overlapping Transcript 3) is an RNA Gene, and is affiliated with the non-coding RNA class. An important paralog of this gene is ST7L.

UniProtKB/Swiss-Prot for ST7-OT3 Gene

  • May act as a tumor suppressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST7-OT3 Gene

Genomics for ST7-OT3 Gene

Regulatory Elements for ST7-OT3 Gene


Promoters for ST7-OT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ST7-OT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ST7-OT3 Gene

Chromosome:
7
Start:
116,953,238 bp from pter
End:
117,230,103 bp from pter
Size:
276,866 bases
Orientation:
Plus strand

Genomic View for ST7-OT3 Gene

Genes around ST7-OT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST7-OT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST7-OT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST7-OT3 Gene

Proteins for ST7-OT3 Gene

  • Protein details for ST7-OT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRC1-ST7_HUMAN
    Recommended name:
    Suppressor of tumorigenicity 7 protein
    Protein Accession:
    Q9NRC1
    Secondary Accessions:
    • A4D0V2
    • Q5CZ72
    • Q7LE31
    • Q7LE32
    • Q8NA32
    • Q8NEJ8
    • Q8TDI9
    • Q9BWX3
    • Q9BWX4
    • Q9NRC2
    • Q9NXZ7

    Protein attributes for ST7-OT3 Gene

    Size:
    585 amino acids
    Molecular mass:
    67166 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB86869.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW83520.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ST7-OT3 Gene

neXtProt entry for ST7-OT3 Gene

Proteomics data for ST7-OT3 Gene at MOPED

Post-translational modifications for ST7-OT3 Gene

  • Ubiquitination at Lys 377 and Lys 384
  • Glycosylation at Asn 47
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ST7-OT3 Gene

Domains & Families for ST7-OT3 Gene

Protein Domains for ST7-OT3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NRC1

UniProtKB/Swiss-Prot:

ST7_HUMAN :
  • Belongs to the ST7 family.
Family:
  • Belongs to the ST7 family.
genes like me logo Genes that share domains with ST7-OT3: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for ST7-OT3 Gene

Function for ST7-OT3 Gene

Molecular function for ST7-OT3 Gene

UniProtKB/Swiss-Prot Function:
May act as a tumor suppressor.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ST7-OT3 Gene

Localization for ST7-OT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST7-OT3 Gene

Membrane; Multi-pass membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ST7-OT3 Gene

Pathways & Interactions for ST7-OT3 Gene

SuperPathways for ST7-OT3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ST7-OT3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ST7-OT3 Gene

Drugs & Compounds for ST7-OT3 Gene

No Compound Related Data Available

Transcripts for ST7-OT3 Gene

mRNA/cDNA for ST7-OT3 Gene

(30) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ST7-OT3 Gene

No ASD Table

Relevant External Links for ST7-OT3 Gene

GeneLoc Exon Structure for
ST7-OT3
ECgene alternative splicing isoforms for
ST7-OT3

Expression for ST7-OT3 Gene

mRNA expression in normal human tissues for ST7-OT3 Gene

mRNA Expression by UniProt/SwissProt for ST7-OT3 Gene

Q9NRC1-ST7_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in heart, liver and pancreas.
genes like me logo Genes that share expression patterns with ST7-OT3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ST7-OT3 Gene

Orthologs for ST7-OT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST7-OT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ST7 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ST7 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ST7 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St7 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ST7 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ST7 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves ST7 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST7 36
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ST7 36
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3634 36
  • 67 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F11A10.5 36
  • 46 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
OneToMany
Species with no ortholog for ST7-OT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ST7-OT3 Gene

ENSEMBL:
Gene Tree for ST7-OT3 (if available)
TreeFam:
Gene Tree for ST7-OT3 (if available)

Paralogs for ST7-OT3 Gene

Paralogs for ST7-OT3 Gene

genes like me logo Genes that share paralogs with ST7-OT3: view

Variants for ST7-OT3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ST7-OT3 Gene

Variant ID Type Subtype PubMed ID
nsv7405 OTHER Inversion 18451855
nsv831108 CNV Gain 17160897
nsv5916 CNV Loss 18451855
esv2628908 CNV Deletion 19546169
esv2232715 CNV Deletion 18987734
esv4717 CNV Deletion 18987735
esv2623394 CNV Deletion 19546169
esv8605 CNV Loss 19470904
nsv366395 CNV Loss 16902084
esv2735063 CNV Deletion 23290073

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Variation tolerance and Relevant External Links for ST7-OT3 Gene

Disorders for ST7-OT3 Gene

Relevant External Links for ST7-OT3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ST7-OT3

No disorders were found for ST7-OT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST7-OT3 Gene

Publications for ST7-OT3 Gene

  1. The RAY1/ST7 tumor-suppressor locus on chromosome 7q31 represents a complex multi-transcript system. (PMID: 12213198) Vincent J.B. … Scherer S.W. (Genomics 2002) 2 3 4 23 67
  2. Recognition of unknown conserved alternatively spliced exons. (PMID: 16110330) Ohler U. … Burge C.B. (PLoS Comput. Biol. 2005) 3
  3. Chromosome 7q: where autism meets language disorder? (PMID: 10889044) Folstein S.E. … Mankoski R.E. (Am. J. Hum. Genet. 2000) 3
  4. Identification of a novel gene on chromosome 7q31 that is interrupted by a translocation breakpoint in an autistic individual. (PMID: 10889047) Vincent J.B. … Scherer S.W. (Am. J. Hum. Genet. 2000) 3

Products for ST7-OT3 Gene

Sources for ST7-OT3 Gene

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