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Aliases for ST7-OT3 Gene

Subcategory (RNA class) for ST7-OT3 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for ST7-OT3 Gene

  • ST7 Overlapping Transcript 3 2 3
  • ST7 3 4 5
  • ST7 Overlapping Transcript 3 (Non-Protein Coding) 2 3
  • Suppression Of Tumorigenicity 7 3 5
  • ST7 Overlapping Transcript 3 (Non-Coding RNA) 3
  • Non-Protein Coding RNA 26 2
  • Protein FAM4A1 4
  • Protein HELG 4
  • NCRNA00026 3
  • ST7OT3 3
  • FAM4A1 4
  • HELG 4
  • RAY1 4

External Ids for ST7-OT3 Gene

Previous HGNC Symbols for ST7-OT3 Gene

  • ST7OT3

Previous GeneCards Identifiers for ST7-OT3 Gene

  • GC07P116823
  • GC07P117182
  • GC07P116964
  • GC07P116968
  • GC07P116972
  • GC07P116977
  • GC07P116982
  • GC07P116986

Summaries for ST7-OT3 Gene

GeneCards Summary for ST7-OT3 Gene

ST7-OT3 (ST7 Overlapping Transcript 3) is an RNA Gene, and is affiliated with the non-coding RNA class. An important paralog of this gene is ST7L.

UniProtKB/Swiss-Prot for ST7-OT3 Gene

  • May act as a tumor suppressor.

Additional gene information for ST7-OT3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST7-OT3 Gene

Genomics for ST7-OT3 Gene

GeneHancer (GH) Regulatory Elements for ST7-OT3 Gene

Promoters and enhancers for ST7-OT3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I116951 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 550.8 +1.0 966 5 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ST7-AS1 ENSG00000275359 ENSG00000277583 ENSG00000273571 ENSG00000273596 ST7 ST7-OT3 ST7-OT4 CAPZA2 ENSG00000276100
GH07I116703 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.1 -246.1 -246080 6.3 NFIB FEZF1 ZNF335 ZNF213 ZNF366 ZSCAN5C SCRT2 RCOR1 FOS ZNF362 MET ST7-OT3 ST7-AS1 CAPZA2 GC07M116730
GH07I116969 Enhancer 0.9 Ensembl ENCODE 0.4 +17.3 17281 1.4 HDGF MEIS2 PKNOX1 BACH1 BATF ZNF316 ATF7 NFE2 IKZF2 RUNX3 TPM3P1 ENSG00000228368 ST7-OT4 ST7-OT3 ST7
GH07I117013 Promoter/Enhancer 1.5 Ensembl ENCODE 0.2 +61.7 61710 2 PKNOX1 ATF1 ARNT TCF12 POLR2B ZNF766 GATA2 E2F8 ATF7 RUNX3 ENSG00000228368 MIR6132 TPM3P1 ST7 ST7-OT3 ST7-OT4
GH07I117019 Promoter/Enhancer 1.4 Ensembl ENCODE 0.2 +67.1 67111 2 HDGF PKNOX1 SMAD1 ATF1 FEZF1 ATF7 NCOA1 REST ZNF592 ATF4 MIR6132 CAPZA2 ST7 ST7-OT3 ST7-OT4 ENSG00000274344
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ST7-OT3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ST7-OT3 Gene

Genomic Locations for ST7-OT3 Gene
chr7:116,953,238-117,230,103
(GRCh38/hg38)
Size:
276,866 bases
Orientation:
Plus strand
chr7:116,822,735-116,861,227
(GRCh37/hg19)

Genomic View for ST7-OT3 Gene

Genes around ST7-OT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST7-OT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST7-OT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST7-OT3 Gene

Proteins for ST7-OT3 Gene

  • Protein details for ST7-OT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRC1-ST7_HUMAN
    Recommended name:
    Suppressor of tumorigenicity 7 protein
    Protein Accession:
    Q9NRC1
    Secondary Accessions:
    • A4D0V2
    • Q5CZ72
    • Q7LE31
    • Q7LE32
    • Q8NA32
    • Q8NEJ8
    • Q8TDI9
    • Q9BWX3
    • Q9BWX4
    • Q9NRC2
    • Q9NXZ7

    Protein attributes for ST7-OT3 Gene

    Size:
    585 amino acids
    Molecular mass:
    67166 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB86869.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW83520.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ST7-OT3 Gene

neXtProt entry for ST7-OT3 Gene

Post-translational modifications for ST7-OT3 Gene

  • Ubiquitination at isoforms=2, 3, 4, 5, 6, 7377 and isoforms=2, 3, 4, 5, 6, 7384
  • Glycosylation at posLast=4747

No data available for DME Specific Peptides for ST7-OT3 Gene

Domains & Families for ST7-OT3 Gene

Protein Domains for ST7-OT3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NRC1

UniProtKB/Swiss-Prot:

ST7_HUMAN :
  • Belongs to the ST7 family.
Family:
  • Belongs to the ST7 family.
genes like me logo Genes that share domains with ST7-OT3: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for ST7-OT3 Gene

Function for ST7-OT3 Gene

Molecular function for ST7-OT3 Gene

UniProtKB/Swiss-Prot Function:
May act as a tumor suppressor.

Phenotypes From GWAS Catalog for ST7-OT3 Gene

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ST7-OT3 Gene

Localization for ST7-OT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST7-OT3 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ST7-OT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST7-OT3: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ST7-OT3 Gene

Pathways & Interactions for ST7-OT3 Gene

SuperPathways for ST7-OT3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ST7-OT3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ST7-OT3 Gene

Drugs & Compounds for ST7-OT3 Gene

No Compound Related Data Available

Transcripts for ST7-OT3 Gene

mRNA/cDNA for ST7-OT3 Gene

(30) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST7-OT3 Gene

No ASD Table

Relevant External Links for ST7-OT3 Gene

GeneLoc Exon Structure for
ST7-OT3
ECgene alternative splicing isoforms for
ST7-OT3

Expression for ST7-OT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST7-OT3 Gene

mRNA Expression by UniProt/SwissProt for ST7-OT3 Gene:

Q9NRC1-ST7_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in heart, liver and pancreas.
genes like me logo Genes that share expression patterns with ST7-OT3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST7-OT3 Gene

Orthologs for ST7-OT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST7-OT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ST7 34
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ST7 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ST7 34
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St7 34
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ST7 34
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ST7 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ST7 34
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST7 34
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ST7 34
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3634 34
  • 67 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F11A10.5 34
  • 46 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 70 (a)
OneToMany
Species where no ortholog for ST7-OT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ST7-OT3 Gene

ENSEMBL:
Gene Tree for ST7-OT3 (if available)
TreeFam:
Gene Tree for ST7-OT3 (if available)

Paralogs for ST7-OT3 Gene

Paralogs for ST7-OT3 Gene

genes like me logo Genes that share paralogs with ST7-OT3: view

Variants for ST7-OT3 Gene

Sequence variations from dbSNP and Humsavar for ST7-OT3 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000006057 -- 117,201,760(+) GTG/G intron_variant
rs1000103435 -- 117,201,545(+) TTTTTTTT/TTTTTTT/TTTTTTTTT intron_variant
rs1000115994 -- 117,185,374(+) G/A intron_variant
rs1000175120 -- 117,182,416(+) T/C upstream_transcript_variant
rs1000261960 -- 117,182,052(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ST7-OT3 Gene

Variant ID Type Subtype PubMed ID
dgv3651n106 CNV deletion 24896259
esv2232715 CNV deletion 18987734
esv2623394 CNV deletion 19546169
esv2628908 CNV deletion 19546169
esv2735063 CNV deletion 23290073
esv3542326 CNV deletion 23714750
esv4717 CNV loss 18987735
esv8605 CNV loss 19470904
nsv1076945 CNV deletion 25765185
nsv1150375 CNV deletion 26484159
nsv366395 CNV deletion 16902084
nsv5916 CNV deletion 18451855
nsv7405 OTHER inversion 18451855
nsv831108 CNV gain 17160897
nsv958457 CNV deletion 24416366

Additional Variant Information for ST7-OT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST7-OT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ST7-OT3 Gene

Disorders for ST7-OT3 Gene

Additional Disease Information for ST7-OT3

No disorders were found for ST7-OT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST7-OT3 Gene

Publications for ST7-OT3 Gene

  1. The RAY1/ST7 tumor-suppressor locus on chromosome 7q31 represents a complex multi-transcript system. (PMID: 12213198) Vincent JB … Scherer SW (Genomics 2002) 2 3 4 22 58
  2. Identification of a novel gene on chromosome 7q31 that is interrupted by a translocation breakpoint in an autistic individual. (PMID: 10889047) Vincent JB … Scherer SW (American journal of human genetics 2000) 3 4 58
  3. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PMID: 18691976) Daub H … Mann M (Molecular cell 2008) 4 58
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  5. ST7-mediated suppression of tumorigenicity of prostate cancer cells is characterized by remodeling of the extracellular matrix. (PMID: 16474848) Hooi CF … Campbell IG (Oncogene 2006) 4 58

Products for ST7-OT3 Gene

Sources for ST7-OT3 Gene

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