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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ST7 Gene

protein-coding GIFtS: 57
GCID: GC07P116595

Suppression Of Tumorigenicity 7

(Previous symbol: FAM4A1)

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Suppression Of Tumorigenicity 7¹ ²		SEN4²
FAM4A1¹ ² ³ ⁵		Family With Sequence Similarity 4, Subfamily A, Member 1²
RAY1² ³ ⁵		Suppression Of Tumorigenicity 7 (Breast)²
HELG² ³		Suppressor Of Tumorigenicity 7 Protein²
TSG7² ⁵		Protein FAM4A1³
ETS7q²		Protein HELG³
FAM4A²

External Ids:	HGNC: 11351¹	Entrez Gene: 7982²	Ensembl: ENSG00000004866⁷	OMIM: 600833⁵	UniProtKB: Q9NRC1³

Export aliases for ST7 gene to outside databases

Previous GC identifers: GC07P115071 GC07P116134 GC07P116147 GC07P116187 GC07P116380

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ST7 Gene:

The gene for this product maps to a region on chromosome 7 identified as an autism-susceptibility locus. Mutation

screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants,

suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The

function of this gene product has not been determined. Transcript variants encoding different isoforms of this

protein have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for ST7 Gene:

ST7 (suppression of tumorigenicity 7) is a protein-coding gene. Diseases associated with ST7 include mandibular cancer, and lemierres syndrome. An important paralog of this gene is ST7L.

UniProtKB/Swiss-Prot: ST7_HUMAN, Q9NRC1

Function: May act as a tumor suppressor

Gene Wiki entry for ST7 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.2 NT_007933.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ST7 gene promoter:
TBP AML1a AP-1 LCR-F1 S8 FOXC1 FOXJ2 (long isoform) TFIID FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): ST7 promoter sequence

Search SABiosciences Chromatin IP Primers for ST7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.2 Ensembl cytogenetic band: 7q31.2 HGNC cytogenetic band: 7q31.2

ST7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST7 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P116595: view genomic region (about GC identifiers)

Start:	116,593,292 bp from pter	End:	116,870,157 bp from pter
Size:	276,866 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 115,988,833-116,265,505

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ST7_HUMAN, Q9NRC1 (See protein sequence)

Recommended Name: Suppressor of tumorigenicity 7 protein

Size: 585 amino acids; 67166 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Sequence caution: Sequence=CAB86869.1; Type=Erroneous initiation; Sequence=EAW83520.1; Type=Erroneous gene model

prediction;

Secondary accessions: A4D0V2 Q5CZ72 Q7LE31 Q7LE32 Q8NA32 Q8NEJ8 Q8TDI9 Q9BWX3 Q9BWX4 Q9NRC2

Q9NXZ7

Alternative splicing: 7 isoforms: Q9NRC1-1 Q9NRC1-2 Q9NRC1-3 Q9NRC1-4 Q9NRC1-5 Q9NRC1-6 Q9NRC1-7

Explore the universe of human proteins at neXtProt for ST7: NX_Q9NRC1

Explore proteomics data for ST7 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9NRC1

ST7 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_060882.2 NP_068708.1

ENSEMBL proteins:

ENSP00000377092 ENSP00000265437 ENSP00000377097 ENSP00000390830 ENSP00000325673

ENSP00000377095 ENSP00000392876 ENSP00000391444 ENSP00000402934 ENSP00000416858

ENSP00000411118 ENSP00000414031 ENSP00000413601 ENSP00000393040 ENSP00000377089

ENSP00000420052 ENSP00000419715 ENSP00000377093 ENSP00000377090 ENSP00000388698

ENSP00000419516

Human Recombinant Protein Products for ST7:

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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for ST7 OriGene Custom MassSpec OriGene Custom Protein Services for ST7
	GenScript Custom Purified and Recombinant Proteins Services for ST7
	Novus Biologicals ST7 Protein Novus Biologicals ST7 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for ST7

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

ST7 for ontologies About GeneDecksing

ST7 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Abcam antibodies for ST7
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	ThermoFisher Antibodies for ST7
	LSBio Antibodies in human, mouse, rat for ST7

Assay Products for ST7:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for ST7
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for ST7 Cloud-Clone Corp. CLIAs for ST7

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

2 InterPro protein domains:

IPR011990 TPR-like_helical

IPR007311 ST7

Graphical View of Domain Structure for InterPro Entry Q9NRC1

ProtoNet protein and cluster: Q9NRC1

UniProtKB/Swiss-Prot: ST7_HUMAN, Q9NRC1

Similarity: Belongs to the ST7 family

ST7 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ST7_HUMAN, Q9NRC1

Function: May act as a tumor suppressor

Phenotypes:
1 GenomeRNAi human phenotype for ST7:

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for ST7

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ST7

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ST7

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ST7

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST7
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate ST7 (see all 9):
		hsa-miR-623 hsa-miR-3065-5p hsa-miR-1271 hsa-let-7a-2* hsa-miR-211 hsa-miR-204 hsa-let-7g* hsa-miR-493*

		SwitchGear 3'UTR luciferase reporter plasmid: ST7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for ST7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST7

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ST7
			Sirion Biotech Customized adenovirus for overexpression of ST7

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for ST7 (see all 15) OriGene ORF clones in mouse, rat for ST7 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ST7 (NM_021908)
		Sino Biological Human cDNA Clone for ST7
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST7
		Sirion Biotech Customized lentivirus for stable overexpression of ST7 Customized lentivirus expression plasmids for stable overexpression of ST7

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ST7
		Search LifeMap BioReagents cell lines for ST7

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST7

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ST7

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/9 Interacting proteins for ST7 (Q9NRC1³ ENSP00000265437⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNB2L1	P63244³, ENSP00000366013⁴	I2D: score=2 STRING: ENSP00000366013
ACTN2	P35609³, ENSP00000355537⁴	I2D: score=1 STRING: ENSP00000355537
NMRK2	Q9NPI5³, ENSP00000168977⁴	I2D: score=1 STRING: ENSP00000168977
MYOT	Q9UBF9³, ENSP00000239926⁴	I2D: score=1 STRING: ENSP00000239926
SNAPIN	O95295³, ENSP00000357674⁴	I2D: score=1 STRING: ENSP00000357674

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ST7

Search CenterWatch for drugs/clinical trials and news about ST7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ST7 gene (2 alternative transcripts):

NM_018412.3 NM_021908.2

Unigene Cluster for ST7:

Suppression of tumorigenicity 7

Hs.368131 [show with all ESTs]

Unigene Representative Sequence: BC075855

18/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):

ENST00000393446 ENST00000265437(uc003vin.3 uc011knl.2) ENST00000393451(uc003vio.3)

ENST00000438863 ENST00000323984 ENST00000393449 ENST00000443979 ENST00000417919

ENST00000446490 ENST00000421345 ENST00000432298(uc003viq.3) ENST00000422922

ENST00000449366 ENST00000487459 ENST00000434836 ENST00000467538 ENST00000393443(uc003vir.3)

ENST00000465133

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST7
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate ST7 (see all 9):
		hsa-miR-623 hsa-miR-3065-5p hsa-miR-1271 hsa-let-7a-2* hsa-miR-211 hsa-miR-204 hsa-let-7g* hsa-miR-493*

		SwitchGear 3'UTR luciferase reporter plasmid: ST7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for ST7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST7

Clone Products:		OriGene clones in human, mouse for ST7 (see all 15) OriGene ORF clones in mouse, rat for ST7 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ST7 (NM_021908)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST7
		Sirion Biotech Customized lentivirus for stable overexpression of ST7 Customized lentivirus expression plasmids for stable overexpression of ST7

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for ST7
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ST7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ST7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST7

Additional mRNA sequence:

AF234882.1 AF234883.1 AF400044.1 AF415174.1 AJ277291.1 AK055405.1 AK093212.1 AK292372.1

AK297510.1 AK297861.1 AK298540.1 AY009152.1 AY009153.1 AY625690.1 BC030954.1 BC075855.1

CR936656.1 DQ102766.1 NR_002332.1

19 DOTS entries:

DT.121062578 DT.40121570 DT.100019685 DT.92423694 DT.95375645 DT.75164392 DT.97838726 DT.102829854

DT.100019684 DT.101354 DT.40106834 DT.100781207 DT.121062585 DT.121062613 DT.121062697 DT.121062725

DT.40306013 DT.91908732 DT.99976764

24/86 AceView cDNA sequences (see all 86):

BQ682159 NM_021908 BC030954 CR590239 BX091425 AA779964 CK299977 AY625690

CA454990 AJ277291 BX379384 AI858600 AI018574 BQ186885 AA721388 CA412521

BC075855 BE765315 AI221163 AK055405 BP871807 AA250756 AI820520 AA644314

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for ST7 (see all 13) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^
SP1:			-		-		-		-		-		-		-		-		-		-		-		-		-
SP2:
SP3:			-		-		-		-		-		-		-		-		-		-		-		-		-														-
SP4:											-				-
SP5:													-

ExUns:	23	^	24a	·	24b	^	25	^	26a	·	26b	^	27a	·	27b
SP1:			-
SP2:			-						-		-
SP3:			-						-		-
SP4:
SP5:

ECgene alternative splicing isoforms for ST7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ST7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

See ST7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ST7

SOURCE GeneReport for Unigene cluster: Hs.368131

UniProtKB/Swiss-Prot: ST7_HUMAN, Q9NRC1

Tissue specificity: Ubiquitously expressed, with highest levels in heart, liver and pancreas

SABiosciences Custom PCR Arrays for ST7

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for ST7
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ST7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ST7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST7

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ST7 gene from 7/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	St7^{1 , 5}	suppression of tumorigenicity 7^{1, 5}	91.7(n)¹ 99.6(a)¹		6 (8.00 cM)⁵ 64213¹ NM_022332.2¹ NP_071727.2¹ 17692933⁵
chicken (Gallus gallus)	Aves	ST7¹	suppression of tumorigenicity 7	83.87(n) 96.03(a)		417770 NM_001105672.1 NP_001099142.1
lizard (Anolis carolinensis)	Reptilia	ST7⁶	Uncharacterized protein	90(a)	1 ↔ 1	5(61311291-61442833)
African clawed frog (Xenopus laevis)	Amphibia	Xl.15351²	Xenopus laevis, clone IMAGE5537022, mRNA	86.02(n)		BC045102.1
zebrafish (Danio rerio)	Actinopterygii	st7¹	suppression of tumorigenicity 7	76.02(n) 94.66(a)		678587 NM_001040336.1 NP_001035426.1
fruit fly (Drosophila melanogaster)	Insecta	CG3634^{1 , 3}	CG3634¹	69(a)³ 63.29(n)¹ 73.96(a)¹		77E8³ 40301¹ NM_141003.2¹ NP_649260.1¹
worm (Caenorhabditis elegans)	Secernentea	F11A10.5^{1 , 3}	Protein F11A10.5¹	49(a)³ 56.98(n)¹ 53.26(a)¹		IV(12094548-12096591)³ 178152¹ NM_069893.3¹ NP_502294.1¹

ENSEMBL Gene Tree for ST7 (if available)
TreeFam Gene Tree for ST7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ST7 gene

ST7L²

2 SIMAP similar genes for ST7 using alignment to 22 protein entries: ST7_HUMAN (see all proteins):

FAM4A1 ST7L

ST7 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_043932⁴		--	--	see VAR_043932	2	A T	mis⁴		0	--	--	--	--
VAR_043933⁴		--	--	see VAR_043933	2	I V	mis⁴		0	--	--	--	--
rs190217659^1,2		--	116591418(+)	`AAGCCA/GGGCCT`	2	--	us2k¹		0	--	--	--	--
rs113345775^1,2	F	--	116591458(+)	`TATCCT/AAATTC`	2	--	us2k¹		3		CSA WA	121
rs181645859^1,2		--	116591726(+)	`TGCAAC/TTTTGT`	2	--	us2k¹		0	--	--	--	--
rs12706126^1,2	C,F,H	--	116591808(+)	`GAAGCA/GTAACT`	2	--	us2k¹		9		NS EA NA	546
rs118046544^1,2	F	--	116600544(+)	`ACATAA/CAATTG`	2	--	int¹		1		EA	120
rs144792023^1,2		--	116600546(+)	`ATAAAA/GTTGTG`	2	--	int¹		0	--	--	--	--
rs73473268^1,2	C,F	--	116600563(+)	`TATTTC/TTAATC`	2	--	int¹		3		WA	122
rs188332572^1,2		--	116600573(+)	`CACTTC/TGAGTT`	2	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ST7 (116593292 - 116843292 bp, first 250kb of ST7)

Structural Variations
Database of Genomic Variants (DGV) 10/19 variations for ST7 (see all 19): About this table

Variant ID	Type	Subtype	PubMed ID
esv1005081	CNV	Deletion	20482838
esv2232715	CNV	Deletion	18987734
esv2659068	CNV	Deletion	23128226
esv2735061	CNV	Deletion	23290073
esv2628908	CNV	Deletion	19546169
esv4717	CNV	Deletion	18987735
esv2623394	CNV	Deletion	19546169
esv2735063	CNV	Deletion	23290073
esv271633	CNV	Insertion	20981092
esv1091175	CNV	Insertion	17803354

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing ST7

DNA2.0 Custom Variant and Variant Library Synthesis for ST7

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 600833 OMIM disorders: --

17 diseases for ST7: About MalaCards

mandibular cancer lemierres syndrome lemierre's syndrome hordeolum

language disorder frozen shoulder autism spectrum disorder meningitis

colorectal cancer mental retardation esophagitis prostatitis

schizophrenia breast cancer hepatocellular carcinoma prostate cancer

lung cancer

2 diseases from the University of Copenhagen DISEASES database for ST7:

Mandibular cancer Atypical autism

ST7 for disorders About GeneDecksing

8 Novoseek inferred disease relationships for ST7 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
somatic mutations	72	6	14534688 (2), 14669308 (1), 14670621 (1), 11726923 (1)
colon carcinoma	54.3	3	12231539 (1), 11279520 (1), 11726923 (1)
tumors	30.4	34	12545169 (5), 14534688 (5), 16474848 (3), 11726923 (3) (see all 11)
carcinoma squamous cell	29.8	1	12231539 (1)
breast cancer	24	5	16474848 (1), 12799635 (1)
colorectal cancer	18.8	1	11726923 (1)
adenocarcinoma	15	1	12231539 (1)
cancer	11.4	9	12231539 (4), 12799635 (2), 16474848 (1), 11279520 (1)

Genetic Association Database (GAD): ST7
Human Genome Epidemiology (HuGE) Navigator: ST7 (7 documents)

Export disorders for ST7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ST7 gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with ST7)

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Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31. (PubMed id 11279520)^{1, 2, 9} Zenklusen J.C.... Green E.D. (2001)
The RAY1/ST7 tumor-suppressor locus on chromosome 7q31 represents a complex multi-transcript system. (PubMed id 12213198)^{1, 2, 9} Vincent J.B.... Scherer S.W. (2002)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (2010)
Recurrent rearrangements in synaptic and neurodevelop mental genes and shared biologic pathways in schizophrenia, autism, and mental retardation. (PubMed id 19736351)^{1, 4} Guilmatre A....Campion D. (2009)
A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)^{1, 4} de Krom M....van Ree J.M. (2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (2003)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
Identification of a novel gene on chromosome 7q31 that is interrupted by a translocation breakpoint in an autistic individual. (PubMed id 10889047)^{1, 2} Vincent J.B....Scherer S.W. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7982	HGNC: 11351	AceView: ST7	Ensembl:ENSG00000004866	euGenes: HUgn7982
ECgene: ST7	H-InvDB: ST7

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ST7	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ST7	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ST7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ST7 gene:
Search GeneIP for patents involving ST7

GeneCards and IP:
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