ST7 Gene

Aliases
for ST7 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC07P115071 GC07P116134 GC07P116147 GC07P116187 GC07P116380

Summaries
for ST7 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for ST7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000007.13  NC_018918.2  NT_007933.16  

SwitchGear Promoter luciferase reporter plasmids (see all 5): ST7 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST7

ST7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P116595:  view genomic region     (about GC identifiers)

Proteins
for ST7 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for ST7: NX_Q9NRC1

Explore proteomics data for ST7 at MOPED

Post-translational modifications: 

ST7 Human Recombinant Protein Products:

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	Search eBioscience for Proteins for ST7
	Search GeneTex for Proteins for ST7
	antibodies-online proteins for ST7 (6 products)
	antibodies-online peptides for ST7

ST7 Antibody Products:

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	antibodies-online antibodies for ST7 (19 products)

ST7 Assay Products:

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	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for ST7 Cloud-Clone Corp. CLIAs for ST7
	Search eBioscience for ELISAs for ST7
	antibodies-online kits for ST7 (18 products)

Domains /
Families
for ST7 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9NRC1

Find genes that share domains with ST7           About GenesLikeMe

Function
for ST7 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Phenotypes:
     1 GenomeRNAi human phenotype for ST7:

genOway: Develop your customized and physiologically relevant rodent model for ST7

miRNA Products:		Block miRNA regulation of human, mouse, rat ST7 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate ST7 (see all 9):
		hsa-miR-623 hsa-miR-3065-5p hsa-miR-1271 hsa-let-7a-2* hsa-miR-211 hsa-miR-204 hsa-let-7g* hsa-miR-493*
		SwitchGear 3'UTR luciferase reporter plasmid: ST7 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ST7
		Predesigned siRNA for gene silencing in human, mouse, rat ST7

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ST7

Clone Products:		OriGene clones in human, mouse for ST7 (see all 13) OriGene ORF clones in mouse, rat for ST7 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ST7 (NM_021908)
		Sino Biological Human cDNA Clone for ST7
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST7

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ST7
		Browse ESI BIO Cell Lines and PureStem Progenitors for ST7

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST7

Localization
for ST7 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytosol	3
nucleus	3
plasma membrane	3
golgi apparatus	2
endoplasmic reticulum	1
mitochondrion	1
peroxisome	1

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for ST7 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Drugs & Compounds
for ST7 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for ST7 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for ST7 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ST7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Eye (Sensory Organs)
Retina

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for ST7
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ST7
		QuantiTect SYBR Green Assays in human, mouse, rat ST7
		QuantiFast Probe-based Assays in human, mouse, rat ST7

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST7

Orthologs
for ST7 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for ST7 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for ST7 gene

ST7L²  

2 SIMAP similar genes for ST7 using alignment to 22 protein entries:     ST7_HUMAN (see all proteins):

FAM4A1    ST7L

Find genes that share paralogs with ST7           About GenesLikeMe

Genomic Variants
for ST7 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ST7 (see all 1954)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1902176591,2		--	116591418(+)	AAGCCA/GGGCCT	2	--	us2k1		0	--	--	--	--
rs1133457751,2	F	--	116591458(+)	TATCCT/AAATTC	2	--	us2k1		3		CSA WA	121
rs1816458591,2		--	116591726(+)	TGCAAC/TTTTGT	2	--	us2k1		0	--	--	--	--
rs127061261,2	C,F,H	--	116591808(+)	GAAGCA/GTAACT	2	--	us2k1		9		NS EA NA	546
rs1180465441,2	F	--	116600544(+)	ACATAA/CAATTG	2	--	int1		1		EA	120
rs1447920231,2		--	116600546(+)	ATAAAA/GTTGTG	2	--	int1		0	--	--	--	--
rs734732681,2	C,F	--	116600563(+)	TATTTC/TTAATC	2	--	int1		3		WA	122
rs1883325721,2		--	116600573(+)	CACTTC/TGAGTT	2	--	int1		0	--	--	--	--
rs1926178551,2	C	--	116600637(+)	AACCAA/CATCTT	2	--	int1		0	--	--	--	--
rs1131723681,2	F	--	116600892(+)	TTGTCG/AATTTT	2	--	int1		1		CSA	2

HapMap Linkage Disequilibrium report for ST7 (116593292 - 116843292 bp, first 250kb of ST7)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for ST7 (see all 19):    About this table    

Variant ID	Type	Subtype	PubMed ID
esv1005081	CNV	Deletion	20482838
esv2232715	CNV	Deletion	18987734
esv2659068	CNV	Deletion	23128226
esv2735061	CNV	Deletion	23290073
esv2628908	CNV	Deletion	19546169
esv4717	CNV	Deletion	18987735
esv2623394	CNV	Deletion	19546169
esv2735063	CNV	Deletion	23290073
esv271633	CNV	Insertion	20981092
esv1091175	CNV	Insertion	17803354

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ST7

DNA2.0 Custom Variant and Variant Library Synthesis for ST7

Disorders / Diseases
for ST7 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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2 diseases for ST7

8 Novoseek inferred disease relationships for ST7 gene    About this table

Publications
for ST7 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

1. Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31. (PubMed id 11279520)^{1, 2, 9} Zenklusen J.C.... Green E.D. (Nat. Genet. 2001)
2. The RAY1/ST7 tumor-suppressor locus on chromosome 7q31 represents a complex multi-transcript system. (PubMed id 12213198)^{1, 2, 9} Vincent J.B.... Scherer S.W. (Genomics 2002)
3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
5. Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation. (PubMed id 19736351)^{1, 4} Guilmatre A....Campion D. (Arch. Gen. Psychiatry 2009)
6. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)^{1, 4} de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
8. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (Science 2003)
9. The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (Nature 2003)
10. Identification of a novel gene on chromosome 7q31 that is interrupted by a translocation breakpoint in an autistic individual. (PubMed id 10889047)^{1, 2} Vincent J.B....Scherer S.W. (Am. J. Hum. Genet. 2000)

External Searches for ST7 gene

Genome Databases showing ST7 gene

Other Databases showing ST7 gene

Specialized Databases showing ST7 gene

Products
for ST7 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section