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ST7 Gene(Protein Coding)

Suppression Of Tumorigenicity 7

GCID:
GC07P116988
GIFtS:
44
Genes Participants
UDN Logo

Aliases for ST7 Gene

Aliases for ST7 Gene

  • Suppression Of Tumorigenicity 7 2 3 5
  • FAM4A1 3 4
  • HELG 3 4
  • RAY1 3 4
  • Family With Sequence Similarity 4, Subfamily A, Member 1 3
  • Suppression Of Tumorigenicity 7 (Breast) 3
  • Suppressor Of Tumorigenicity 7 Protein 3
  • Protein FAM4A1 4
  • Protein HELG 4
  • ETS7q 3
  • FAM4A 3
  • SEN4 3
  • TSG7 3

External Ids for ST7 Gene

Previous HGNC Symbols for ST7 Gene

  • FAM4A1

Previous GeneCards Identifiers for ST7 Gene

  • GC07P115071
  • GC07P116134
  • GC07P116147
  • GC07P116187
  • GC07P116380
  • GC07P116595
  • GC07P116957
  • GC07P116962
  • GC07P116966
  • GC07P116970
  • GC07P116975
  • GC07P116980
  • GC07P116984

Summaries for ST7 Gene

Entrez Gene Summary for ST7 Gene

  • The gene for this product maps to a region on chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST7 Gene

ST7 (Suppression Of Tumorigenicity 7) is a Protein Coding gene. Diseases associated with ST7 include Mandibular Cancer and Jaw Cancer. An important paralog of this gene is ST7L.

UniProtKB/Swiss-Prot for ST7 Gene

  • May act as a tumor suppressor.

Gene Wiki entry for ST7 Gene

Additional gene information for ST7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST7 Gene

Genomics for ST7 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for ST7 Gene

Promoters and enhancers for ST7 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07I116951 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 550.8 +1.0 966 5 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ST7-AS1 ENSG00000275359 ENSG00000277583 ENSG00000273571 ST7 ST7-OT3 ST7-OT4 ENSG00000273596 CAPZA2 ENSG00000276100
GH07I116314 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 4.6 -636.6 -636567 5.2 PKNOX1 SIN3A BATF IRF4 RAD21 RFX5 ZNF302 RCOR1 FOS IKZF2 CAV2 LOC102724434 ENSG00000237813 ENSG00000243220 ENSG00000235427 TES ST7 ENSG00000213167 ENSG00000243243 LOC105375463
GH07I116438 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 4.3 -510.0 -509975 10.3 PKNOX1 ATF1 ARNT NEUROD1 SIN3A BRCA1 TCF12 FOS NCOA1 REST CAV2 ENSG00000237813 ENSG00000235427 ENSG00000243220 ENSG00000243243 ST7 CAV1 PIR33191
GH07I116670 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.3 -280.1 -280066 5.9 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 MET TES CAV2 ST7 GC07M116730
GH07I116248 Enhancer 0.6 dbSUPER 4.6 -703.0 -702952 2.7 CTCF FOXA2 HLF CEBPB CEBPG RAD21 FOXA1 NFIL3 CEBPA SMC3 TES TFEC ENSG00000235427 LOC102724434 ST7 GC07P116253 ENSG00000279086 ENSG00000243243 ENSG00000237813
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ST7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ST7 gene promoter:

Genomic Locations for ST7 Gene

Genomic Locations for ST7 Gene
chr7:116,953,238-117,230,103
(GRCh38/hg38)
Size:
276,866 bases
Orientation:
Plus strand
chr7:116,593,292-116,870,157
(GRCh37/hg19)

Genomic View for ST7 Gene

Genes around ST7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST7 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ST7 Gene

Proteins for ST7 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ST7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRC1-ST7_HUMAN
    Recommended name:
    Suppressor of tumorigenicity 7 protein
    Protein Accession:
    Q9NRC1
    Secondary Accessions:
    • A4D0V2
    • Q5CZ72
    • Q7LE31
    • Q7LE32
    • Q8NA32
    • Q8NEJ8
    • Q8TDI9
    • Q9BWX3
    • Q9BWX4
    • Q9NRC2
    • Q9NXZ7

    Protein attributes for ST7 Gene

    Size:
    585 amino acids
    Molecular mass:
    67166 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB86869.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW83520.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ST7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ST7 Gene

Protein Expression for ST7 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ST7 Gene

  • Ubiquitination at isoforms=2, 3, 4, 5, 6, 7377 and isoforms=2, 3, 4, 5, 6, 7384
  • Glycosylation at posLast=4747

Other Protein References for ST7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ST7 Gene

Domains & Families for ST7 Gene

Gene Families for ST7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ST7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ST7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRC1

UniProtKB/Swiss-Prot:

ST7_HUMAN :
  • Belongs to the ST7 family.
Family:
  • Belongs to the ST7 family.
genes like me logo Genes that share domains with ST7: view

Function for ST7 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ST7 Gene

UniProtKB/Swiss-Prot Function:
May act as a tumor suppressor.

Phenotypes From GWAS Catalog for ST7 Gene

genes like me logo Genes that share phenotypes with ST7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ST7 Gene

Localization for ST7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST7 gene
Compartment Confidence
plasma membrane 3
nucleus 3
cytosol 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ST7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST7: view

Pathways & Interactions for ST7 Gene

SuperPathways for ST7 Gene

PathCards logo More details on SuperPathways for ST7
No Data Available

Gene Ontology (GO) - Biological Process for ST7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ST7 Gene

Drugs & Compounds for ST7 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ST7 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ST7 Gene

(2) REFSEQ mRNAs :
(19) Additional mRNA sequences :
(86) Selected AceView cDNA sequences:
(30) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ST7 Gene

Suppression of tumorigenicity 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST7 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - - - - - - - - - - - -
SP2:
SP3: - - - - - - - - - - - - - -
SP4: - -
SP5: -
SP6: -
SP7:
SP8: - - - - - - - - - -
SP9: -
SP10: - - -
SP11: - - - - -
SP12: - - -
SP13: - -

ExUns: 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b
SP1: -
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for ST7 Gene

GeneLoc Exon Structure for
ST7
ECgene alternative splicing isoforms for
ST7

Expression for ST7 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST7 Gene

mRNA expression in normal human tissues for ST7 Gene
mRNA expression by BioGPS for ST7 GenemRNA expression by GTEx for ST7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ST7 Gene

This gene is overexpressed in NK cells (18.6), Fetal Brain (10.8), Frontal cortex (10.6), Islet of Langerhans (7.9), and Liver (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ST7 Gene



NURSA nuclear receptor signaling pathways regulating expression of ST7 Gene:

ST7

SOURCE GeneReport for Unigene cluster for ST7 Gene:

Hs.368131

mRNA Expression by UniProt/SwissProt for ST7 Gene:

Q9NRC1-ST7_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in heart, liver and pancreas.

Evidence on tissue expression from TISSUES for ST7 Gene

  • Intestine(4.5)
  • Kidney(4.4)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ST7: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST7 Gene

Orthologs for ST7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ST7 33 34
  • 99.52 (n)
cow
(Bos Taurus)
 Mammalia ST7 33 34
  • 94.83 (n)
dog
(Canis familiaris)
 Mammalia ST7 33 34
  • 93.98 (n)
rat
(Rattus norvegicus)
 Mammalia ST7 33
  • 92.6 (n)
oppossum
(Monodelphis domestica)
 Mammalia ST7 34
  • 92 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia St7 33 16 34
  • 91.7 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia ST7 34
  • 70 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves ST7 33 34
  • 83.87 (n)
lizard
(Anolis carolinensis)
 Reptilia ST7 34
  • 89 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia st7 33
  • 82.37 (n)
Str.18600 33
African clawed frog
(Xenopus laevis)
 Amphibia Xl.15351 33
zebrafish
(Danio rerio)
 Actinopterygii ST7 34
  • 77 (a)
 OneToOne
st7 33
  • 75.63 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP007524 33
  • 63.29 (n)
fruit fly
(Drosophila melanogaster)
 Insecta CG3634 35 33 34
  • 63.22 (n)
worm
(Caenorhabditis elegans)
 Secernentea F11A10.5 35 33 34
  • 56.49 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 70 (a)
 OneToMany
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.14179 33
Species where no ortholog for ST7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ST7 Gene

ENSEMBL:
Gene Tree for ST7 (if available)
TreeFam:
Gene Tree for ST7 (if available)

Paralogs for ST7 Gene

Variants for ST7 Gene

Sequence variations from dbSNP and Humsavar for ST7 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs550492993 likely-pathogenic, Brain atrophy, Global developmental delay, Intractable seizure 117,130,530(+) T/C/G coding_sequence_variant, stop_gained, synonymous_variant
rs1000000059 -- 117,106,550(+) G/A intron_variant
rs1000002830 -- 117,033,923(+) G/A intron_variant
rs1000006057 -- 117,201,760(+) GTG/G intron_variant
rs1000009442 -- 117,224,959(+) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ST7 Gene

Variant ID Type Subtype PubMed ID
dgv1324e214 CNV gain 21293372
dgv3651n106 CNV deletion 24896259
esv1005081 CNV deletion 20482838
esv1091175 CNV insertion 17803354
esv2232715 CNV deletion 18987734
esv2623394 CNV deletion 19546169
esv2628908 CNV deletion 19546169
esv2659068 CNV deletion 23128226
esv2735061 CNV deletion 23290073
esv2735063 CNV deletion 23290073
esv3307357 CNV mobile element insertion 20981092
esv3399621 CNV insertion 20981092
esv3542326 CNV deletion 23714750
esv3576422 CNV gain 25503493
esv3614703 CNV gain 21293372
esv3614704 CNV gain 21293372
esv3614705 CNV loss 21293372
esv3614707 CNV gain 21293372
esv3614710 CNV loss 21293372
esv3891196 CNV gain 25118596
esv4717 CNV loss 18987735
esv8605 CNV loss 19470904
nsv1075053 CNV deletion 25765185
nsv1076945 CNV deletion 25765185
nsv1140839 CNV deletion 24896259
nsv1144198 CNV deletion 24896259
nsv1150375 CNV deletion 26484159
nsv366395 CNV deletion 16902084
nsv477330 CNV novel sequence insertion 20440878
nsv527321 CNV loss 19592680
nsv5916 CNV deletion 18451855
nsv7405 OTHER inversion 18451855
nsv824281 CNV gain 20364138
nsv831107 CNV gain 17160897
nsv831108 CNV gain 17160897
nsv958457 CNV deletion 24416366
nsv981571 CNV duplication 23825009

Variation tolerance for ST7 Gene

Residual Variation Intolerance Score: 36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST7 Gene

Human Gene Mutation Database (HGMD)
ST7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST7 Gene

Disorders for ST7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ST7 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
mandibular cancer
  • malignant neoplasm of inferior maxilla
jaw cancer
  • jaw neoplasm
autism
  • autistic disorder
- elite association - COSMIC cancer census association via MalaCards
Search ST7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ST7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ST7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST7 Gene

Publications for ST7 Gene

  1. The RAY1/ST7 tumor-suppressor locus on chromosome 7q31 represents a complex multi-transcript system. (PMID: 12213198) Vincent JB … Scherer SW (Genomics 2002) 3 4 22 58
  2. Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31. (PMID: 11279520) Zenklusen JC … Green ED (Nature genetics 2001) 3 4 22 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M … van Ree JM (Biological psychiatry 2009) 3 44 58

Products for ST7 Gene

Sources for ST7 Gene

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