Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ST7 Gene

Aliases for ST7 Gene

  • Suppression Of Tumorigenicity 7 2 3
  • FAM4A1 3 4
  • HELG 3 4
  • RAY1 3 4
  • Family With Sequence Similarity 4, Subfamily A, Member 1 3
  • Suppression Of Tumorigenicity 7 (Breast) 3
  • Protein FAM4A1 4
  • Protein HELG 4
  • ETS7q 3
  • FAM4A 3
  • SEN4 3
  • TSG7 3

External Ids for ST7 Gene

Previous HGNC Symbols for ST7 Gene

  • FAM4A1

Previous GeneCards Identifiers for ST7 Gene

  • GC07P115071
  • GC07P116134
  • GC07P116147
  • GC07P116187
  • GC07P116380
  • GC07P116595
  • GC07P116957

Summaries for ST7 Gene

Entrez Gene Summary for ST7 Gene

  • The gene for this product maps to a region on chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST7 Gene

ST7 (Suppression Of Tumorigenicity 7) is a Protein Coding gene. Diseases associated with ST7 include jaw cancer and mandibular cancer. An important paralog of this gene is ST7L.

UniProtKB/Swiss-Prot for ST7 Gene

  • May act as a tumor suppressor.

Gene Wiki entry for ST7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST7 Gene

Genomics for ST7 Gene

Regulatory Elements for ST7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ST7 Gene

Chromosome:
7
Start:
116,953,238 bp from pter
End:
117,230,103 bp from pter
Size:
276,866 bases
Orientation:
Plus strand

Genomic View for ST7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ST7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST7 Gene

Proteins for ST7 Gene

  • Protein details for ST7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRC1-ST7_HUMAN
    Recommended name:
    Suppressor of tumorigenicity 7 protein
    Protein Accession:
    Q9NRC1
    Secondary Accessions:
    • A4D0V2
    • Q5CZ72
    • Q7LE31
    • Q7LE32
    • Q8NA32
    • Q8NEJ8
    • Q8TDI9
    • Q9BWX3
    • Q9BWX4
    • Q9NRC2
    • Q9NXZ7

    Protein attributes for ST7 Gene

    Size:
    585 amino acids
    Molecular mass:
    67166 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB86869.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW83520.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ST7 Gene

neXtProt entry for ST7 Gene

Proteomics data for ST7 Gene at MOPED

Post-translational modifications for ST7 Gene

  • Ubiquitination at Lys 377 and Lys 384
  • Glycosylation at Asn 47
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ST7 Gene

Domains & Families for ST7 Gene

Protein Domains for ST7 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NRC1

UniProtKB/Swiss-Prot:

ST7_HUMAN :
  • Belongs to the ST7 family.
Family:
  • Belongs to the ST7 family.
genes like me logo Genes that share domains with ST7: view

No data available for Gene Families for ST7 Gene

Function for ST7 Gene

Molecular function for ST7 Gene

UniProtKB/Swiss-Prot Function:
May act as a tumor suppressor.
genes like me logo Genes that share phenotypes with ST7: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ST7 Gene

Localization for ST7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST7 Gene COMPARTMENTS Subcellular localization image for ST7 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ST7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST7: view

Pathways & Interactions for ST7 Gene

SuperPathways for ST7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ST7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ST7 Gene

Drugs & Compounds for ST7 Gene

No Compound Related Data Available

Transcripts for ST7 Gene

Unigene Clusters for ST7 Gene

Suppression of tumorigenicity 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ST7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST7 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - - - - - - - - - - - -
SP2:
SP3: - - - - - - - - - - - - - -
SP4: - -
SP5: -
SP6: -
SP7:
SP8: - - - - - - - - - -
SP9: -
SP10: - - -
SP11: - - - - -
SP12: - - -
SP13: - -

ExUns: 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b
SP1: -
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for ST7 Gene

GeneLoc Exon Structure for
ST7
ECgene alternative splicing isoforms for
ST7

Expression for ST7 Gene

mRNA expression in normal human tissues for ST7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ST7 Gene

This gene is overexpressed in NK cells (18.6), Fetal Brain (10.8), Frontal cortex (10.6), Islet of Langerhans (7.9), and Liver (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ST7 Gene



SOURCE GeneReport for Unigene cluster for ST7 Gene Hs.368131

mRNA Expression by UniProt/SwissProt for ST7 Gene

Q9NRC1-ST7_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in heart, liver and pancreas.
genes like me logo Genes that share expression patterns with ST7: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ST7 Gene

Orthologs for ST7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ST7 35
  • 94.83 (n)
  • 99.82 (a)
ST7 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ST7 35
  • 93.98 (n)
  • 98.56 (a)
ST7 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St7 35
  • 91.7 (n)
  • 99.6 (a)
St7 16
St7 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ST7 35
  • 99.52 (n)
  • 100 (a)
ST7 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia ST7 35
  • 92.6 (n)
  • 99.28 (a)
oppossum
(Monodelphis domestica)
Mammalia ST7 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ST7 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ST7 35
  • 83.87 (n)
  • 96.03 (a)
ST7 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST7 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st7 35
  • 82.37 (n)
  • 96.03 (a)
Str.18600 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15351 35
zebrafish
(Danio rerio)
Actinopterygii st7 35
  • 75.63 (n)
  • 94.07 (a)
ST7 36
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3634 37
  • 69 (a)
CG3634 35
  • 63.22 (n)
  • 73.16 (a)
CG3634 36
  • 67 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007524 35
  • 63.29 (n)
  • 75.15 (a)
worm
(Caenorhabditis elegans)
Secernentea F11A10.5 37
  • 49 (a)
F11A10.5 35
  • 56.49 (n)
  • 53.05 (a)
F11A10.5 36
  • 46 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14179 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
OneToMany
Species with no ortholog for ST7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ST7 Gene

ENSEMBL:
Gene Tree for ST7 (if available)
TreeFam:
Gene Tree for ST7 (if available)

Paralogs for ST7 Gene

Paralogs for ST7 Gene

genes like me logo Genes that share paralogs with ST7: view

Variants for ST7 Gene

Sequence variations from dbSNP and Humsavar for ST7 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs467 -- 117,168,272(+) TTTGC(A/G)TATGC intron-variant
rs38861 -- 117,176,230(+) TCAAA(A/C)GAACT intron-variant
rs38862 -- 117,176,412(+) GAAAT(A/G)CTTTC intron-variant
rs38863 -- 117,177,738(+) TATTT(C/G)TTCAG intron-variant
rs38864 -- 117,178,239(+) TGAAG(C/T)ACGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST7 Gene

Variant ID Type Subtype PubMed ID
nsv7405 OTHER Inversion 18451855
nsv831107 CNV Gain 17160897
dgv7465n71 CNV Gain 21882294
esv2659068 CNV Deletion 23128226
esv2735061 CNV Deletion 23290073
esv1005081 CNV Deletion 20482838
nsv527321 CNV Loss 19592680
esv1091175 CNV Insertion 17803354
nsv831108 CNV Gain 17160897
esv271633 CNV Insertion 20981092
nsv824281 CNV Gain 20364138
nsv5916 CNV Loss 18451855
esv2628908 CNV Deletion 19546169
esv2232715 CNV Deletion 18987734
esv4717 CNV Deletion 18987735
esv2623394 CNV Deletion 19546169
esv8605 CNV Loss 19470904
nsv366395 CNV Loss 16902084
esv2735063 CNV Deletion 23290073

Variation tolerance for ST7 Gene

Residual Variation Intolerance Score: 36.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ST7 Gene

HapMap Linkage Disequilibrium report
ST7
Human Gene Mutation Database (HGMD)
ST7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST7 Gene

Disorders for ST7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ST7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
jaw cancer
  • neoplasm of jaw
mandibular cancer
  • mandible cancer
atypical autism
  • pdd nos
- elite association
Search ST7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ST7

Genetic Association Database (GAD)
ST7
Human Genome Epidemiology (HuGE) Navigator
ST7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ST7
genes like me logo Genes that share disorders with ST7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST7 Gene

Publications for ST7 Gene

  1. ST7-mediated suppression of tumorigenicity of prostate cancer cells is characterized by remodeling of the extracellular matrix. (PMID: 16474848) Hooi C.S.-F. … Campbell I.G. (Oncogene 2006) 23 67
  2. Extensive analysis of the 7q31 region in human prostate tumors supports TES as the best candidate tumor suppressor gene. (PMID: 15252854) ChA-ne L. … Latil A. (Int. J. Cancer 2004) 23 67
  3. Chromosome 7q31 allelic imbalance and somatic mutations of RAY1/ST7 gene in colorectal cancer. (PMID: 14670621) Haddad R. … Gallinger S. (Cancer Lett. 2004) 23 67
  4. Somatic mutation analysis of p53 and ST7 tumor suppressor genes in gastric carcinoma by DHPLC. (PMID: 14669308) Lu C. … Zhang X. (World J. Gastroenterol. 2003) 23 67
  5. Mutational analysis of the ST7 gene in human myeloid tumor cell lines. (PMID: 14534688) Sivasundaram K. … Hosokawa Y. (Oncol. Rep. 2003) 23 67

Products for ST7 Gene

Sources for ST7 Gene

Back to Top

Content