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Aliases for ST7 Gene

Aliases for ST7 Gene

  • Suppression Of Tumorigenicity 7 2 3
  • FAM4A1 3 4 6
  • RAY1 3 4 6
  • TSG7 3 6
  • HELG 3 4
  • Family With Sequence Similarity 4, Subfamily A, Member 1 3
  • Suppression Of Tumorigenicity 7 (Breast) 3
  • Suppressor Of Tumorigenicity 7 Protein 3
  • Protein FAM4A1 4
  • Protein HELG 4
  • ETS7q 3
  • FAM4A 3
  • SEN4 3

External Ids for ST7 Gene

Previous HGNC Symbols for ST7 Gene

  • FAM4A1

Previous GeneCards Identifiers for ST7 Gene

  • GC07P115071
  • GC07P116134
  • GC07P116147
  • GC07P116187
  • GC07P116380
  • GC07P116595

Summaries for ST7 Gene

Entrez Gene Summary for ST7 Gene

  • The gene for this product maps to a region on chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST7 Gene

ST7 (Suppression Of Tumorigenicity 7) is a Protein Coding gene. Diseases associated with ST7 include mandibular cancer and atypical autism. An important paralog of this gene is ST7L.

UniProtKB/Swiss-Prot for ST7 Gene

  • May act as a tumor suppressor.

Gene Wiki entry for ST7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST7 Gene

Genomics for ST7 Gene

Regulatory Elements for ST7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ST7 Gene

Start:
116,953,238 bp from pter
End:
117,230,103 bp from pter
Size:
276,866 bases
Orientation:
Plus strand

Genomic View for ST7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ST7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST7 Gene

Proteins for ST7 Gene

  • Protein details for ST7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRC1-ST7_HUMAN
    Recommended name:
    Suppressor of tumorigenicity 7 protein
    Protein Accession:
    Q9NRC1
    Secondary Accessions:
    • A4D0V2
    • Q5CZ72
    • Q7LE31
    • Q7LE32
    • Q8NA32
    • Q8NEJ8
    • Q8TDI9
    • Q9BWX3
    • Q9BWX4
    • Q9NRC2
    • Q9NXZ7

    Protein attributes for ST7 Gene

    Size:
    585 amino acids
    Molecular mass:
    67166 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB86869.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW83520.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ST7 Gene

neXtProt entry for ST7 Gene

Proteomics data for ST7 Gene at MOPED

Post-translational modifications for ST7 Gene

  • Ubiquitination at Lys377, Lys384, and Lys418
  • Glycosylation at Asn47
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ST7 Gene

Domains for ST7 Gene

Protein Domains for ST7 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NRC1

UniProtKB/Swiss-Prot:

ST7_HUMAN :
  • Q9NRC1
Family:
  • Belongs to the ST7 family.
genes like me logo Genes that share domains with ST7: view

No data available for Gene Families for ST7 Gene

Function for ST7 Gene

Molecular function for ST7 Gene

UniProtKB/Swiss-Prot Function: May act as a tumor suppressor.

Phenotypes for ST7 Gene

GenomeRNAi human phenotypes for ST7:
genes like me logo Genes that share phenotypes with ST7: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ST7 Gene

Localization for ST7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST7 Gene COMPARTMENTS Subcellular localization image for ST7 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 3
golgi apparatus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ST7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST7: view

Pathways for ST7 Gene

SuperPathways for ST7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ST7 Gene

None

No data available for Pathways by source for ST7 Gene

Transcripts for ST7 Gene

Unigene Clusters for ST7 Gene

Suppression of tumorigenicity 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ST7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ST7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST7 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - - - - - - - - - - - -
SP2:
SP3: - - - - - - - - - - - - - -
SP4: - -
SP5: -
SP6: -
SP7:
SP8: - - - - - - - - - -
SP9: -
SP10: - - -
SP11: - - - - -
SP12: - - -
SP13: - -

ExUns: 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b
SP1: -
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for ST7 Gene

GeneLoc Exon Structure for
ST7
ECgene alternative splicing isoforms for
ST7

Expression for ST7 Gene

mRNA expression in normal human tissues for ST7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ST7 Gene

SOURCE GeneReport for Unigene cluster for ST7 Gene Hs.368131

mRNA Expression by UniProt/SwissProt for ST7 Gene

Q9NRC1-ST7_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in heart, liver and pancreas.
genes like me logo Genes that share expressions with ST7: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ST7 Gene

Orthologs for ST7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST7 35
  • 99.52 (n)
  • 100 (a)
ST7 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ST7 35
  • 94.83 (n)
  • 99.82 (a)
ST7 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ST7 35
  • 93.98 (n)
  • 98.56 (a)
ST7 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St7 35
  • 91.7 (n)
  • 99.6 (a)
St7 16
St7 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ST7 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ST7 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia ST7 35
  • 92.6 (n)
  • 99.28 (a)
chicken
(Gallus gallus)
Aves ST7 35
  • 83.87 (n)
  • 96.03 (a)
ST7 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST7 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15351 35
tropical clawed frog
(Silurana tropicalis)
Amphibia st7 35
  • 82.37 (n)
  • 96.03 (a)
Str.18600 35
zebrafish
(Danio rerio)
Actinopterygii st7 35
  • 75.63 (n)
  • 94.07 (a)
ST7 36
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007524 35
  • 63.29 (n)
  • 75.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3634 35
  • 63.22 (n)
  • 73.16 (a)
CG3634 36
  • 67 (a)
OneToMany
CG3634 37
  • 69 (a)
worm
(Caenorhabditis elegans)
Secernentea F11A10.5 35
  • 56.49 (n)
  • 53.05 (a)
F11A10.5 36
  • 46 (a)
OneToMany
F11A10.5 37
  • 49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14179 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
OneToMany
Species with no ortholog for ST7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ST7 Gene

ENSEMBL:
Gene Tree for ST7 (if available)
TreeFam:
Gene Tree for ST7 (if available)

Paralogs for ST7 Gene

Paralogs for ST7 Gene

genes like me logo Genes that share paralogs with ST7: view

Variants for ST7 Gene

Sequence variations from dbSNP and Humsavar for ST7 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs467 -- 117,168,272(+) TTTGC(A/G)TATGC intron-variant
rs38861 -- 117,176,230(+) TCAAA(A/C)GAACT intron-variant
rs38862 -- 117,176,412(+) GAAAT(A/G)CTTTC intron-variant
rs38863 -- 117,177,738(+) TATTT(C/G)TTCAG intron-variant
rs38864 -- 117,178,239(+) TGAAG(C/T)ACGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST7 Gene

Variant ID Type Subtype PubMed ID
nsv7405 OTHER Inversion 18451855
nsv831107 CNV Gain 17160897
dgv7465n71 CNV Gain 21882294
esv2659068 CNV Deletion 23128226
esv2735061 CNV Deletion 23290073
esv1005081 CNV Deletion 20482838
nsv527321 CNV Loss 19592680
esv1091175 CNV Insertion 17803354
nsv831108 CNV Gain 17160897
esv271633 CNV Insertion 20981092
nsv824281 CNV Gain 20364138
nsv5916 CNV Loss 18451855
esv2628908 CNV Deletion 19546169
esv2232715 CNV Deletion 18987734
esv4717 CNV Deletion 18987735
esv2623394 CNV Deletion 19546169
esv8605 CNV Loss 19470904
nsv366395 CNV Loss 16902084
esv2735063 CNV Deletion 23290073

Relevant External Links for ST7 Gene

HapMap Linkage Disequilibrium report
ST7
Human Gene Mutation Database (HGMD)
ST7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST7 Gene

Disorders for ST7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ST7 Gene including...

Search for ST7 Gene in MalaCards »

(2) University of Copenhagen DISEASES for ST7 Gene

(8) Novoseek inferred disease relationships for ST7 Gene

Disease -log(P) Hits PubMed IDs
somatic mutations 72 5
colon carcinoma 54.3 3
tumors 30.4 26
carcinoma squamous cell 29.8 1
breast cancer 24 2

Relevant External Links for ST7

Genetic Association Database (GAD)
ST7
Human Genome Epidemiology (HuGE) Navigator
ST7
genes like me logo Genes that share disorders with ST7: view

No data available for UniProtKB/Swiss-Prot for ST7 Gene

Publications for ST7 Gene

  1. Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31. (PMID: 11279520) Zenklusen J.C. … Green E.D. (Nat. Genet. 2001) 3 4 23
  2. The RAY1/ST7 tumor-suppressor locus on chromosome 7q31 represents a complex multi-transcript system. (PMID: 12213198) Vincent J.B. … Scherer S.W. (Genomics 2002) 3 4 23
  3. Absence of ST7 gene alterations in human cancer. (PMID: 12231539) Dong S.M. … Sidransky D. (Clin. Cancer Res. 2002) 3 23
  4. An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma. (PMID: 12545169) Wang S. … Meltzer S.J. (Oncogene 2003) 3 23
  5. Mutation of the ST7 tumor suppressor gene on 7q31.1 is rare in breast, ovarian and colorectal cancers. (PMID: 11726923) Thomas N.A. … Campbell I.G. (Nat. Genet. 2001) 4 23

Products for ST7 Gene

Sources for ST7 Gene

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