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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ST7 Gene

protein-coding   GIFtS: 57
GCID: GC07P116595

Suppression Of Tumorigenicity 7


(Previous symbol: FAM4A1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Suppression Of Tumorigenicity 71 2     SEN42
FAM4A11 2 3 5     Family With Sequence Similarity 4, Subfamily A, Member 12
RAY12 3 5     Suppression Of Tumorigenicity 7 (Breast)2
HELG2 3     Suppressor Of Tumorigenicity 7 Protein2
TSG72 5     Protein FAM4A13
ETS7q2     Protein HELG3
FAM4A2     

External Ids:    HGNC: 113511   Entrez Gene: 79822   Ensembl: ENSG000000048667   OMIM: 6008335   UniProtKB: Q9NRC13   

Export aliases for ST7 gene to outside databases

Previous GC identifers: GC07P115071 GC07P116134 GC07P116147 GC07P116187 GC07P116380


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ST7 Gene:
The gene for this product maps to a region on chromosome 7 identified as an autism-susceptibility locus. Mutation
screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants,
suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The
function of this gene product has not been determined. Transcript variants encoding different isoforms of this
protein have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for ST7 Gene: 
ST7 (suppression of tumorigenicity 7) is a protein-coding gene. Diseases associated with ST7 include mandibular cancer, and lemierres syndrome. An important paralog of this gene is ST7L.

UniProtKB/Swiss-Prot: ST7_HUMAN, Q9NRC1
Function: May act as a tumor suppressor

Gene Wiki entry for ST7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ST7 gene promoter:
         TBP   AML1a   AP-1   LCR-F1   S8   FOXC1   FOXJ2 (long isoform)   TFIID   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): ST7 promoter sequence
   Search SABiosciences Chromatin IP Primers for ST7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.2   Ensembl cytogenetic band:  7q31.2   HGNC cytogenetic band: 7q31.2

ST7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST7 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P116595:  view genomic region     (about GC identifiers)

Start:
116,593,292 bp from pter      End:
116,870,157 bp from pter
Size:
276,866 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 115,988,833-116,265,505     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ST7_HUMAN, Q9NRC1 (See protein sequence)
Recommended Name: Suppressor of tumorigenicity 7 protein  
Size: 585 amino acids; 67166 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=CAB86869.1; Type=Erroneous initiation; Sequence=EAW83520.1; Type=Erroneous gene model
prediction;
Secondary accessions: A4D0V2 Q5CZ72 Q7LE31 Q7LE32 Q8NA32 Q8NEJ8 Q8TDI9 Q9BWX3 Q9BWX4 Q9NRC2
Q9NXZ7
Alternative splicing: 7 isoforms:  Q9NRC1-1   Q9NRC1-2   Q9NRC1-3   Q9NRC1-4   Q9NRC1-5   Q9NRC1-6   Q9NRC1-7   

Explore the universe of human proteins at neXtProt for ST7: NX_Q9NRC1

Explore proteomics data for ST7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NRC1

  • ST7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ST7 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_060882.2  NP_068708.1  

    ENSEMBL proteins: 
     ENSP00000377092   ENSP00000265437   ENSP00000377097   ENSP00000390830   ENSP00000325673  
     ENSP00000377095   ENSP00000392876   ENSP00000391444   ENSP00000402934   ENSP00000416858  
     ENSP00000411118   ENSP00000414031   ENSP00000413601   ENSP00000393040   ENSP00000377089  
     ENSP00000420052   ENSP00000419715   ENSP00000377093   ENSP00000377090   ENSP00000388698  
     ENSP00000419516  

    Human Recombinant Protein Products for ST7: 
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    OriGene Protein Over-expression Lysate for ST7
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ST7
    GenScript Custom Purified and Recombinant Proteins Services for ST7
    Novus Biologicals ST7 Protein
    Novus Biologicals ST7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ST7 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    ST7 for ontologies           About GeneDecksing



    ST7 Antibody Products: 
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    ThermoFisher Antibodies for ST7
    LSBio Antibodies in human, mouse, rat for ST7 

    Assay Products for ST7: 
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    Cloud-Clone Corp. ELISAs for ST7 
    Cloud-Clone Corp. CLIAs for ST7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR007311 ST7

    Graphical View of Domain Structure for InterPro Entry Q9NRC1

    ProtoNet protein and cluster: Q9NRC1

    UniProtKB/Swiss-Prot: ST7_HUMAN, Q9NRC1
    Similarity: Belongs to the ST7 family


    ST7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST7_HUMAN, Q9NRC1
    Function: May act as a tumor suppressor

    Phenotypes:
         1 GenomeRNAi human phenotype for ST7:

     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ST7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ST7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ST7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ST7 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST7
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate ST7 (see all 9):
    hsa-miR-623 hsa-miR-3065-5p hsa-miR-1271 hsa-let-7a-2* hsa-miR-211 hsa-miR-204 hsa-let-7g* hsa-miR-493*
    SwitchGear 3'UTR luciferase reporter plasmidST7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ST7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ST7
    Sirion Biotech Customized adenovirus for overexpression of ST7

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ST7 (see all 15)
    OriGene ORF clones in mouse, rat for ST7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ST7 (NM_021908)
    Sino Biological Human cDNA Clone for ST7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST7
    Sirion Biotech Customized lentivirus for stable overexpression of ST7 
                         Customized lentivirus expression plasmids for stable overexpression of ST7 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ST7
    Search LifeMap BioReagents cell lines for ST7
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ST7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for ST7 (Q9NRC13 ENSP000002654374) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNB2L1P632443, ENSP000003660134I2D: score=2 STRING: ENSP00000366013
    ACTN2P356093, ENSP000003555374I2D: score=1 STRING: ENSP00000355537
    NMRK2Q9NPI53, ENSP000001689774I2D: score=1 STRING: ENSP00000168977
    MYOTQ9UBF93, ENSP000002399264I2D: score=1 STRING: ENSP00000239926
    SNAPINO952953, ENSP000003576744I2D: score=1 STRING: ENSP00000357674
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ST7

    Search CenterWatch for drugs/clinical trials and news about ST7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ST7 gene (2 alternative transcripts): 
    NM_018412.3  NM_021908.2  

    Unigene Cluster for ST7:

    Suppression of tumorigenicity 7
    Hs.368131  [show with all ESTs]
    Unigene Representative Sequence: BC075855
    18/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):
    ENST00000393446 ENST00000265437(uc003vin.3 uc011knl.2) ENST00000393451(uc003vio.3)
    ENST00000438863 ENST00000323984 ENST00000393449 ENST00000443979 ENST00000417919
    ENST00000446490 ENST00000421345 ENST00000432298(uc003viq.3) ENST00000422922
    ENST00000449366 ENST00000487459 ENST00000434836 ENST00000467538 ENST00000393443(uc003vir.3)
    ENST00000465133
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST7
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate ST7 (see all 9):
    hsa-miR-623 hsa-miR-3065-5p hsa-miR-1271 hsa-let-7a-2* hsa-miR-211 hsa-miR-204 hsa-let-7g* hsa-miR-493*
    SwitchGear 3'UTR luciferase reporter plasmidST7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ST7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST7
    Clone
    Products:
         
    OriGene clones in human, mouse for ST7 (see all 15)
    OriGene ORF clones in mouse, rat for ST7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ST7 (NM_021908)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST7
    Sirion Biotech Customized lentivirus for stable overexpression of ST7 
                         Customized lentivirus expression plasmids for stable overexpression of ST7 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ST7
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ST7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ST7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST7

    Additional mRNA sequence: 

    AF234882.1 AF234883.1 AF400044.1 AF415174.1 AJ277291.1 AK055405.1 AK093212.1 AK292372.1 
    AK297510.1 AK297861.1 AK298540.1 AY009152.1 AY009153.1 AY625690.1 BC030954.1 BC075855.1 
    CR936656.1 DQ102766.1 NR_002332.1 

    19 DOTS entries:

    DT.121062578  DT.40121570  DT.100019685  DT.92423694  DT.95375645  DT.75164392  DT.97838726  DT.102829854 
    DT.100019684  DT.101354  DT.40106834  DT.100781207  DT.121062585  DT.121062613  DT.121062697  DT.121062725 
    DT.40306013  DT.91908732  DT.99976764 

    24/86 AceView cDNA sequences (see all 86):

    BQ682159 NM_021908 BC030954 CR590239 BX091425 AA779964 CK299977 AY625690 
    CA454990 AJ277291 BX379384 AI858600 AI018574 BQ186885 AA721388 CA412521 
    BC075855 BE765315 AI221163 AK055405 BP871807 AA250756 AI820520 AA644314 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for ST7 (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:        -     -     -     -     -     -     -     -     -     -     -     -     -                                                                           
    SP2:                                                                                                                                                            
    SP3:        -     -     -     -     -     -     -     -     -     -     -     -     -                                         -                                 
    SP4:                                -           -                                                                                                               
    SP5:                                      -                                                                                                                     

    ExUns: 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b
    SP1:        -                                       
    SP2:        -                 -     -               
    SP3:        -                 -     -               
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for ST7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ST7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ST7 Expression
    About this image


    See ST7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ST7

    SOURCE GeneReport for Unigene cluster: Hs.368131

    UniProtKB/Swiss-Prot: ST7_HUMAN, Q9NRC1
    Tissue specificity: Ubiquitously expressed, with highest levels in heart, liver and pancreas

        SABiosciences Custom PCR Arrays for ST7
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ST7 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St71 , 5 suppression of tumorigenicity 71, 5 91.7(n)1
    99.6(a)1
      6 (8.00 cM)5
    642131  NM_022332.21  NP_071727.21 
     176929335 
    chicken
    (Gallus gallus)
    Aves ST71 suppression of tumorigenicity 7 83.87(n)
    96.03(a)
      417770  NM_001105672.1  NP_001099142.1 
    lizard
    (Anolis carolinensis)
    Reptilia ST76
    Uncharacterized protein
    90(a)
    1 ↔ 1
    5(61311291-61442833)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.153512 Xenopus laevis, clone IMAGE5537022, mRNA 86.02(n)    BC045102.1 
    zebrafish
    (Danio rerio)
    Actinopterygii st71 suppression of tumorigenicity 7 76.02(n)
    94.66(a)
      678587  NM_001040336.1  NP_001035426.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG36341 , 3 CG36341 69(a)3
    63.29(n)1
    73.96(a)1
      77E83
    403011  NM_141003.21  NP_649260.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F11A10.51 , 3 Protein F11A10.51 49(a)3
    56.98(n)1
    53.26(a)1
      IV(12094548-12096591)3
    1781521  NM_069893.31  NP_502294.11 


    ENSEMBL Gene Tree for ST7 (if available)
    TreeFam Gene Tree for ST7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ST7 gene
    ST7L2  
    2 SIMAP similar genes for ST7 using alignment to 22 protein entries:     ST7_HUMAN (see all proteins):
    FAM4A1    ST7L

    ST7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1954 SNPs in ST7 are shown (see all 1954)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0439324
    ----see VAR_0439322 A T mis40--------
    VAR_0439334
    ----see VAR_0439332 I V mis40--------
    rs1902176591,2
    --116591418(+) AAGCCA/GGGCCT 2 -- us2k10--------
    rs1133457751,2
    F--116591458(+) TATCCT/AAATTC 2 -- us2k13Minor allele frequency- A:0.08CSA WA 121
    rs1816458591,2
    --116591726(+) TGCAAC/TTTTGT 2 -- us2k10--------
    rs127061261,2
    C,F,H--116591808(+) GAAGCA/GTAACT 2 -- us2k19Minor allele frequency- G:0.11NS EA NA 546
    rs1180465441,2
    F--116600544(+) ACATAA/CAATTG 2 -- int11Minor allele frequency- C:0.01EA 120
    rs1447920231,2
    --116600546(+) ATAAAA/GTTGTG 2 -- int10--------
    rs734732681,2
    C,F--116600563(+) TATTTC/TTAATC 2 -- int13Minor allele frequency- T:0.12WA 122
    rs1883325721,2
    --116600573(+) CACTTC/TGAGTT 2 -- int10--------

    HapMap Linkage Disequilibrium report for ST7 (116593292 - 116843292 bp, first 250kb of ST7)

    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for ST7 (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1005081CNV Deletion20482838
    esv2232715CNV Deletion18987734
    esv2659068CNV Deletion23128226
    esv2735061CNV Deletion23290073
    esv2628908CNV Deletion19546169
    esv4717CNV Deletion18987735
    esv2623394CNV Deletion19546169
    esv2735063CNV Deletion23290073
    esv271633CNV Insertion20981092
    esv1091175CNV Insertion17803354

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600833    OMIM disorders: --

    17 diseases for ST7:    About MalaCards
    mandibular cancer    lemierres syndrome    lemierre's syndrome    hordeolum
    language disorder    frozen shoulder    autism spectrum disorder    meningitis
    colorectal cancer    mental retardation    esophagitis    prostatitis
    schizophrenia    breast cancer    hepatocellular carcinoma    prostate cancer
    lung cancer

    2 diseases from the University of Copenhagen DISEASES database for ST7:
    Mandibular cancer     Atypical autism

    ST7 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for ST7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    somatic mutations 72 6 14534688 (2), 14669308 (1), 14670621 (1), 11726923 (1)
    colon carcinoma 54.3 3 12231539 (1), 11279520 (1), 11726923 (1)
    tumors 30.4 34 12545169 (5), 14534688 (5), 16474848 (3), 11726923 (3) (see all 11)
    carcinoma squamous cell 29.8 1 12231539 (1)
    breast cancer 24 5 16474848 (1), 12799635 (1)
    colorectal cancer 18.8 1 11726923 (1)
    adenocarcinoma 15 1 12231539 (1)
    cancer 11.4 9 12231539 (4), 12799635 (2), 16474848 (1), 11279520 (1)

    Genetic Association Database (GAD): ST7
    Human Genome Epidemiology (HuGE) Navigator: ST7 (7 documents)

    Export disorders for ST7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ST7 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with ST7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31. (PubMed id 11279520)1, 2, 9 Zenklusen J.C.... Green E.D. (2001)
    2. The RAY1/ST7 tumor-suppressor locus on chromosome 7q31 represents a complex multi-transcript system. (PubMed id 12213198)1, 2, 9 Vincent J.B.... Scherer S.W. (2002)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Recurrent rearrangements in synaptic and neurodevelop mental genes and shared biologic pathways in schizophrenia, autism, and mental retardation. (PubMed id 19736351)1, 4 Guilmatre A....Campion D. (2009)
    6. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (2009)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    9. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    10. Identification of a novel gene on chromosome 7q31 that is interrupted by a translocation breakpoint in an autistic individual. (PubMed id 10889047)1, 2 Vincent J.B....Scherer S.W. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7982 HGNC: 11351 AceView: ST7 Ensembl:ENSG00000004866 euGenes: HUgn7982
    ECgene: ST7 H-InvDB: ST7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ST7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ST7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ST7 gene:
    Search GeneIP for patents involving ST7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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