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Aliases for ST6GALNAC6 Gene

Aliases for ST6GALNAC6 Gene

  • ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 6 2 3
  • SIAT7F 3 4 6
  • Sialytransferase 7 ((Alpha-N-Acetylneuraminyl 2,3-Betagalactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialytransferase) F 2 3
  • GalNAc Alpha-2,6-Sialyltransferase VI 3 4
  • Sialyltransferase 7F 3 4
  • ST6GALNACVI 3 4
  • SIAT7-F 3 4
  • CMP-NeuAC:(Beta)-N-Acetylgalactosaminide (Alpha)2,6-Sialyltransferase Member VI 3
  • Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 6 3
  • HST6GalNAc VI 4
  • ST6GalNAc VI 4
  • EC 2.4.99.7 63
  • EC 2.4.99.- 4
  • EC 2.4.99 63

External Ids for ST6GALNAC6 Gene

Previous HGNC Symbols for ST6GALNAC6 Gene

  • SIAT7F

Previous GeneCards Identifiers for ST6GALNAC6 Gene

  • GC09M122294
  • GC09M124101
  • GC09M126023
  • GC09M127729
  • GC09M129687
  • GC09M130647
  • GC09M100265

Summaries for ST6GALNAC6 Gene

Entrez Gene Summary for ST6GALNAC6 Gene

  • ST6GALNAC6 belongs to a family of sialyltransferases that modify proteins and ceramides on the cell surface to alter cell-cell or cell-extracellular matrix interactions (Tsuchida et al., 2003 [PubMed 12668675]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ST6GALNAC6 Gene

ST6GALNAC6 (ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 6) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosphingolipid biosynthesis - ganglio series. GO annotations related to this gene include sialyltransferase activity and alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. An important paralog of this gene is ST6GAL1.

UniProtKB/Swiss-Prot for ST6GALNAC6 Gene

  • Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney. Participates in the synthesis of disialyl Lewis a (Le(a)).

Gene Wiki entry for ST6GALNAC6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST6GALNAC6 Gene

Genomics for ST6GALNAC6 Gene

Regulatory Elements for ST6GALNAC6 Gene

Transcription factor binding sites by QIAGEN in the ST6GALNAC6 gene promoter:

Genomic Location for ST6GALNAC6 Gene

Start:
127,885,321 bp from pter
End:
127,906,731 bp from pter
Size:
21,411 bases
Orientation:
Minus strand

Genomic View for ST6GALNAC6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ST6GALNAC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST6GALNAC6 Gene

Proteins for ST6GALNAC6 Gene

  • Protein details for ST6GALNAC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969X2-SIA7F_HUMAN
    Recommended name:
    Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
    Protein Accession:
    Q969X2
    Secondary Accessions:
    • B3KQ01
    • Q5T9C4
    • Q5T9C5
    • Q9H8A2
    • Q9ULB8

    Protein attributes for ST6GALNAC6 Gene

    Size:
    333 amino acids
    Molecular mass:
    38068 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The carbohydrate antigen disialyl Lewis a, which is at least partly synthesized by ST6GALNAC6, is a normal counterpart of sialyl Lewis a, better known as CA19-9, an antigen widely used as a serum marker for diagnosis of cancers in the digestive track. Disialyl Lewis a is predominantly expressed in non-malignant epithelial cells of the digestive organs, while sialyl Lewis a is preferentially expressed in cancers. Disialyl Lewis a in normal epithelial cells serves as a ligand for immunosuppressive receptors, such as SIGLEC7 and SIGLEC9, expressed on resident monocytes/macrophages and maintains immunological homeostasis of mucosal membranes in digestive organs. Sialyl Lewis a, as well as its positional isomer sialyl Lewis x, serves as a ligand for vascular cell adhesion molecule E-selectin and facilitates hematogenous metastasis through mediating adhesion of circulating cancer cells to vascular endothelium (PubMed:17760270).
    SequenceCaution:
    • Sequence=CAI12610.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12611.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW87712.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ST6GALNAC6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ST6GALNAC6 Gene

Proteomics data for ST6GALNAC6 Gene at MOPED

Selected DME Specific Peptides for ST6GALNAC6 Gene

Post-translational modifications for ST6GALNAC6 Gene

  • Glycosylation at Asn98
  • Modification sites at PhosphoSitePlus

Domains for ST6GALNAC6 Gene

Gene Families for ST6GALNAC6 Gene

HGNC:
  • ST3G :Sialyltransferases

Protein Domains for ST6GALNAC6 Gene

Graphical View of Domain Structure for InterPro Entry

Q969X2

UniProtKB/Swiss-Prot:

SIA7F_HUMAN :
  • Q969X2
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST6GALNAC6: view

Function for ST6GALNAC6 Gene

Molecular function for ST6GALNAC6 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.33 mM for GM1b {ECO:0000269 PubMed:12668675}; KM=0.46 mM for sialyl-Lc4 {ECO:0000269 PubMed:12668675};
UniProtKB/Swiss-Prot Function: Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney. Participates in the synthesis of disialyl Lewis a (Le(a)).
UniProtKB/Swiss-Prot Induction: Down-regulated in renal cancers

Enzyme Numbers (IUBMB) for ST6GALNAC6 Gene

Gene Ontology (GO) - Molecular Function for ST6GALNAC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity ISS --
GO:0008373 sialyltransferase activity ISS 12668675
genes like me logo Genes that share ontologies with ST6GALNAC6: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ST6GALNAC6 Gene

Localization for ST6GALNAC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST6GALNAC6 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST6GALNAC6 Gene COMPARTMENTS Subcellular localization image for ST6GALNAC6 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
endoplasmic reticulum 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ST6GALNAC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005737 cytoplasm ISS --
GO:0005794 Golgi apparatus --
GO:0005886 plasma membrane NAS 10702226
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST6GALNAC6: view

Pathways for ST6GALNAC6 Gene

genes like me logo Genes that share pathways with ST6GALNAC6: view

Pathways by source for ST6GALNAC6 Gene

1 BioSystems pathway for ST6GALNAC6 Gene

Interacting Proteins for ST6GALNAC6 Gene

Gene Ontology (GO) - Biological Process for ST6GALNAC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001574 ganglioside biosynthetic process ISS --
GO:0006486 protein glycosylation --
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006677 glycosylceramide metabolic process IDA 17123352
GO:0006687 glycosphingolipid metabolic process IDA 17123352
genes like me logo Genes that share ontologies with ST6GALNAC6: view

Compounds for ST6GALNAC6 Gene

(1) HMDB Compounds for ST6GALNAC6 Gene

Compound Synonyms Cas Number PubMed IDs
Disialosyl galactosyl globoside
  • Disialosylgalactosylgloboside
71764-07-3
genes like me logo Genes that share compounds with ST6GALNAC6: view

Transcripts for ST6GALNAC6 Gene

Unigene Clusters for ST6GALNAC6 Gene

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g ^ 9
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - - -
SP9: - - - - - - -
SP10: - - - -
SP11: -
SP12: - - - -
SP13: - -

Relevant External Links for ST6GALNAC6 Gene

GeneLoc Exon Structure for
ST6GALNAC6
ECgene alternative splicing isoforms for
ST6GALNAC6

Expression for ST6GALNAC6 Gene

mRNA expression in normal human tissues for ST6GALNAC6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ST6GALNAC6 Gene

SOURCE GeneReport for Unigene cluster for ST6GALNAC6 Gene Hs.109672

mRNA Expression by UniProt/SwissProt for ST6GALNAC6 Gene

Q969X2-SIA7F_HUMAN
Tissue specificity: Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines.
genes like me logo Genes that share expressions with ST6GALNAC6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ST6GALNAC6 Gene

Orthologs for ST6GALNAC6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST6GALNAC6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST6GALNAC6 35
  • 98.1 (n)
  • 96.4 (a)
ST6GALNAC6 36
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ST6GALNAC6 35
  • 90.46 (n)
  • 92.17 (a)
ST6GALNAC6 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ST6GALNAC6 35
  • 91.49 (n)
  • 96.4 (a)
ST6GALNAC6 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St6galnac6 35
  • 89.79 (n)
  • 93.09 (a)
St6galnac6 16
St6galnac6 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ST6GALNAC6 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ST6GALNAC6 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia St6galnac6 35
  • 89.61 (n)
  • 95.48 (a)
chicken
(Gallus gallus)
Aves ST6GALNAC6 35
  • 75.48 (n)
  • 75.25 (a)
ST6GALNAC6 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST6GALNAC6 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st6galnac6 35
  • 65.43 (n)
  • 65.2 (a)
zebrafish
(Danio rerio)
Actinopterygii st6galnac6 35
  • 63.31 (n)
  • 54.21 (a)
st6galnac6 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ST6Gal 36
  • 12 (a)
OneToMany
Species with no ortholog for ST6GALNAC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST6GALNAC6 Gene

ENSEMBL:
Gene Tree for ST6GALNAC6 (if available)
TreeFam:
Gene Tree for ST6GALNAC6 (if available)

Paralogs for ST6GALNAC6 Gene

Paralogs for ST6GALNAC6 Gene

Selected SIMAP similar genes for ST6GALNAC6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ST6GALNAC6: view

Variants for ST6GALNAC6 Gene

Sequence variations from dbSNP and Humsavar for ST6GALNAC6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs913981 -- 127,886,066(+) ATGCC(A/G)GCCTC utr-variant-3-prime, downstream-variant-500B
rs913982 -- 127,886,240(+) CCCAG(C/G)AGAGT utr-variant-3-prime, downstream-variant-500B
rs913983 -- 127,886,401(+) TAACC(A/G)CATAG utr-variant-3-prime, downstream-variant-500B
rs1043012 -- 127,908,373(-) GCCAG(C/T)CGCCA upstream-variant-2KB
rs1053520 -- 127,885,435(-) GACCA(A/G)ATGGA utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ST6GALNAC6 Gene

Variant ID Type Subtype PubMed ID
nsv893859 CNV Loss 21882294
nsv893860 CNV Gain 21882294
nsv893865 CNV Loss 21882294
dgv8287n71 CNV Loss 21882294
nsv893874 CNV Loss 21882294
dgv8290n71 CNV Loss 21882294
dgv8291n71 CNV Loss 21882294
dgv497n21 CNV Loss 19592680
dgv8293n71 CNV Loss 21882294

Relevant External Links for ST6GALNAC6 Gene

HapMap Linkage Disequilibrium report
ST6GALNAC6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST6GALNAC6 Gene

Disorders for ST6GALNAC6 Gene

No disorders were found for ST6GALNAC6 Gene.

No data available for UniProtKB/Swiss-Prot for ST6GALNAC6 Gene

Publications for ST6GALNAC6 Gene

  1. Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides. (PMID: 12668675) Tsuchida A. … Furukawa K. (J. Biol. Chem. 2003) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. (PMID: 15843597) Harduin-Lepers A. … Oriol R. (Glycobiology 2005) 3 4
  5. Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers. (PMID: 17123352) Senda M. … Furukawa K. (Biochem. J. 2007) 3 4

Products for ST6GALNAC6 Gene

Sources for ST6GALNAC6 Gene

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