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Aliases for ST6GALNAC6 Gene

Aliases for ST6GALNAC6 Gene

  • ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 6 2 3 5
  • Sialytransferase 7 ((Alpha-N-Acetylneuraminyl 2,3-Betagalactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialytransferase) F 2 3
  • ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 6 2 3
  • ST6 GalNAc Alpha-2,6-Sialyltransferase 6 2 3
  • GalNAc Alpha-2,6-Sialyltransferase VI 3 4
  • Sialyltransferase 7F 3 4
  • ST6GALNACVI 3 4
  • SIAT7-F 3 4
  • SIAT7F 3 4
  • CMP-NeuAC:(Beta)-N-Acetylgalactosaminide (Alpha)2,6-Sialyltransferase Member VI 3
  • Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 6 3
  • ST6 -N-Acetylgalactosaminide Alpha-26-Sialyltransferase 6 3
  • HST6GalNAc VI 4
  • ST6GalNAc VI 4
  • EC 2.4.99.7 61
  • EC 2.4.99.- 4
  • EC 2.4.99 61

External Ids for ST6GALNAC6 Gene

Previous HGNC Symbols for ST6GALNAC6 Gene

  • SIAT7F

Previous GeneCards Identifiers for ST6GALNAC6 Gene

  • GC09M122294
  • GC09M124101
  • GC09M126023
  • GC09M127729
  • GC09M129687
  • GC09M130647
  • GC09M100265

Summaries for ST6GALNAC6 Gene

Entrez Gene Summary for ST6GALNAC6 Gene

  • ST6GALNAC6 belongs to a family of sialyltransferases that modify proteins and ceramides on the cell surface to alter cell-cell or cell-extracellular matrix interactions (Tsuchida et al., 2003 [PubMed 12668675]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ST6GALNAC6 Gene

ST6GALNAC6 (ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 6) is a Protein Coding gene. Among its related pathways are Synthesis of substrates in N-glycan biosythesis and Glycosphingolipid biosynthesis - ganglio series. GO annotations related to this gene include sialyltransferase activity and alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. An important paralog of this gene is ST6GALNAC5.

UniProtKB/Swiss-Prot for ST6GALNAC6 Gene

  • Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney. Participates in the synthesis of disialyl Lewis a (Le(a)).

Gene Wiki entry for ST6GALNAC6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST6GALNAC6 Gene

Genomics for ST6GALNAC6 Gene

Regulatory Elements for ST6GALNAC6 Gene

Enhancers for ST6GALNAC6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G127826 2 FANTOM5 Ensembl ENCODE dbSUPER 12.3 +78.5 78524 3.7 HDGF CREB3L1 AGO1 ARID4B YY1 SLC30A9 REST ZNF592 KAT8 MEF2D FPGS ENG FAM129B AK1 ST6GALNAC6 ST6GALNAC4 PIP5KL1 CDK9 ENSG00000227218 TOR2A
GH09G127860 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.9 +44.8 44813 3.7 HDGF PKNOX1 MLX CREB3L1 ARNT ZNF766 ZNF263 MEF2D SREBF1 SMARCA4 ST6GALNAC6 LOC102723566 FPGS PTRH1 TTC16 CDK9 TOR2A FAM129B CERCAM ODF2
GH09G127761 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +139.9 139898 11.3 HDGF PKNOX1 MLX ARNT SIN3A ARID4B DMAP1 ZBTB7B YY1 ZNF143 FPGS ENG SH2D3C LOC102723566 AK1 ST6GALNAC6 ST6GALNAC4 PIP5KL1 FAM129B SWI5
GH09G127864 1.5 Ensembl ENCODE dbSUPER 12.9 +41.3 41308 1.7 HDGF PKNOX1 ZNF133 GLI4 ZNF48 ZNF2 ZNF121 ZNF766 GLIS2 GATA2 LOC102723566 ST6GALNAC6 RPL12 FPGS PTRH1 TTC16 URM1 ANGPTL2 PKN3 FAM102A
GH09G127824 1.4 Ensembl ENCODE dbSUPER 12.3 +81.3 81305 1.5 PKNOX1 ATF1 AGO1 ZFP64 ARID4B DMAP1 ZNF48 SP5 MXD4 REST ENG FPGS AK1 ST6GALNAC6 ST6GALNAC4 PIP5KL1 ENSG00000222421 LOC102723566
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ST6GALNAC6 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ST6GALNAC6 gene promoter:

Genomic Location for ST6GALNAC6 Gene

Chromosome:
9
Start:
127,885,321 bp from pter
End:
127,906,731 bp from pter
Size:
21,411 bases
Orientation:
Minus strand

Genomic View for ST6GALNAC6 Gene

Genes around ST6GALNAC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST6GALNAC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST6GALNAC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST6GALNAC6 Gene

Proteins for ST6GALNAC6 Gene

  • Protein details for ST6GALNAC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969X2-SIA7F_HUMAN
    Recommended name:
    Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
    Protein Accession:
    Q969X2
    Secondary Accessions:
    • B3KQ01
    • Q5T9C4
    • Q5T9C5
    • Q9H8A2
    • Q9ULB8

    Protein attributes for ST6GALNAC6 Gene

    Size:
    333 amino acids
    Molecular mass:
    38068 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The carbohydrate antigen disialyl Lewis a, which is at least partly synthesized by ST6GALNAC6, is a normal counterpart of sialyl Lewis a, better known as CA19-9, an antigen widely used as a serum marker for diagnosis of cancers in the digestive track. Disialyl Lewis a is predominantly expressed in non-malignant epithelial cells of the digestive organs, while sialyl Lewis a is preferentially expressed in cancers. Disialyl Lewis a in normal epithelial cells serves as a ligand for immunosuppressive receptors, such as SIGLEC7 and SIGLEC9, expressed on resident monocytes/macrophages and maintains immunological homeostasis of mucosal membranes in digestive organs. Sialyl Lewis a, as well as its positional isomer sialyl Lewis x, serves as a ligand for vascular cell adhesion molecule E-selectin and facilitates hematogenous metastasis through mediating adhesion of circulating cancer cells to vascular endothelium (PubMed:17760270).
    SequenceCaution:
    • Sequence=CAI12610.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12611.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW87712.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ST6GALNAC6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ST6GALNAC6 Gene

Selected DME Specific Peptides for ST6GALNAC6 Gene

Q969X2:
  • HHRFITEKRVF
  • HRFITEK
  • LSTGWFT
  • TVFIFWGP
  • IRMNDAPT

Post-translational modifications for ST6GALNAC6 Gene

  • Glycosylation at isoforms=2, 398
  • Modification sites at PhosphoSitePlus

Domains & Families for ST6GALNAC6 Gene

Gene Families for ST6GALNAC6 Gene

Protein Domains for ST6GALNAC6 Gene

Graphical View of Domain Structure for InterPro Entry

Q969X2

UniProtKB/Swiss-Prot:

SIA7F_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST6GALNAC6: view

Function for ST6GALNAC6 Gene

Molecular function for ST6GALNAC6 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.33 mM for GM1b {ECO:0000269 PubMed:12668675}; KM=0.46 mM for sialyl-Lc4 {ECO:0000269 PubMed:12668675};
UniProtKB/Swiss-Prot Function:
Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney. Participates in the synthesis of disialyl Lewis a (Le(a)).
UniProtKB/Swiss-Prot Induction:
Down-regulated in renal cancers.

Enzyme Numbers (IUBMB) for ST6GALNAC6 Gene

Gene Ontology (GO) - Molecular Function for ST6GALNAC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity TAS --
GO:0008373 sialyltransferase activity ISS 12668675
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ST6GALNAC6: view
genes like me logo Genes that share phenotypes with ST6GALNAC6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ST6GALNAC6

miRNA for ST6GALNAC6 Gene

miRTarBase miRNAs that target ST6GALNAC6

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ST6GALNAC6 Gene

Localization for ST6GALNAC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST6GALNAC6 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST6GALNAC6 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 5
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ST6GALNAC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005737 cytoplasm ISS --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane NAS 10702226
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ST6GALNAC6: view

Pathways & Interactions for ST6GALNAC6 Gene

genes like me logo Genes that share pathways with ST6GALNAC6: view

Interacting Proteins for ST6GALNAC6 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000291839%0d%0a9606.ENSP00000345477%0d%0a9606.ENSP00000321343%0d%0a9606.ENSP00000318445%0d%0a
Selected Interacting proteins: Q969X2-SIA7F_HUMAN ENSP00000291839 for ST6GALNAC6 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ST6GALNAC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001574 ganglioside biosynthetic process ISS --
GO:0006486 protein glycosylation IEA --
GO:0006677 glycosylceramide metabolic process IDA 17123352
GO:0006687 glycosphingolipid metabolic process IDA 17123352
GO:0009100 glycoprotein metabolic process IDA 17123352
genes like me logo Genes that share ontologies with ST6GALNAC6: view

No data available for SIGNOR curated interactions for ST6GALNAC6 Gene

Drugs & Compounds for ST6GALNAC6 Gene

(1) Additional Compounds for ST6GALNAC6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Disialosyl galactosyl globoside
  • Disialosyl galactosyl globoside
  • Disialosylgalactosylgloboside
  • DSGG
  • Neuacalpha2-3Galbeta1-3(neuacalpha2-6)galnac
  • O-(N-Acetyl-alpha-neuraminosyl)-(2->6)-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-beta-D-galactopyranosyl-(1->3)]-2-(acetylamino)-2-deoxy-D-Galactose
71764-07-3
genes like me logo Genes that share compounds with ST6GALNAC6: view

Transcripts for ST6GALNAC6 Gene

Unigene Clusters for ST6GALNAC6 Gene

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g ^ 9
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - - -
SP9: - - - - - - -
SP10: - - - -
SP11: -
SP12: - - - -
SP13: - -

Relevant External Links for ST6GALNAC6 Gene

GeneLoc Exon Structure for
ST6GALNAC6
ECgene alternative splicing isoforms for
ST6GALNAC6

Expression for ST6GALNAC6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST6GALNAC6 Gene

Protein differential expression in normal tissues from HIPED for ST6GALNAC6 Gene

This gene is overexpressed in Colon (19.7), Heart (14.9), Rectum (10.2), Synovial fluid (8.6), Fetal gut (8.0), and Monocytes (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ST6GALNAC6 Gene



Protein tissue co-expression partners for ST6GALNAC6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ST6GALNAC6 Gene:

ST6GALNAC6

SOURCE GeneReport for Unigene cluster for ST6GALNAC6 Gene:

Hs.109672

mRNA Expression by UniProt/SwissProt for ST6GALNAC6 Gene:

Q969X2-SIA7F_HUMAN
Tissue specificity: Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines.

Evidence on tissue expression from TISSUES for ST6GALNAC6 Gene

  • Nervous system(4.9)
  • Muscle(4.4)
  • Intestine(4.3)
  • Thyroid gland(4.2)
genes like me logo Genes that share expression patterns with ST6GALNAC6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST6GALNAC6 Gene

Orthologs for ST6GALNAC6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST6GALNAC6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST6GALNAC6 34 35
  • 98.1 (n)
dog
(Canis familiaris)
Mammalia ST6GALNAC6 34 35
  • 91.49 (n)
cow
(Bos Taurus)
Mammalia ST6GALNAC6 34 35
  • 90.46 (n)
mouse
(Mus musculus)
Mammalia St6galnac6 34 16 35
  • 89.79 (n)
rat
(Rattus norvegicus)
Mammalia St6galnac6 34
  • 89.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ST6GALNAC6 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ST6GALNAC6 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves ST6GALNAC6 34 35
  • 75.48 (n)
lizard
(Anolis carolinensis)
Reptilia ST6GALNAC6 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st6galnac6 34
  • 65.43 (n)
zebrafish
(Danio rerio)
Actinopterygii st6galnac6 34 35
  • 63.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta ST6Gal 35
  • 12 (a)
OneToMany
Species where no ortholog for ST6GALNAC6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST6GALNAC6 Gene

ENSEMBL:
Gene Tree for ST6GALNAC6 (if available)
TreeFam:
Gene Tree for ST6GALNAC6 (if available)

Paralogs for ST6GALNAC6 Gene

Paralogs for ST6GALNAC6 Gene

(3) SIMAP similar genes for ST6GALNAC6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ST6GALNAC6: view

Variants for ST6GALNAC6 Gene

Sequence variations from dbSNP and Humsavar for ST6GALNAC6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000209056 -- 127,897,743(+) AGGCG(C/T)CCAGG intron-variant, upstream-variant-2KB
rs1000224713 -- 127,900,931(+) GTGAG(A/C)CGAGA intron-variant, upstream-variant-2KB
rs1000452293 -- 127,895,293(+) GGAGG(C/T)TCCTT intron-variant
rs1000456356 -- 127,902,319(+) ACGCC(C/T)AGCTA intron-variant
rs1000560336 -- 127,902,139(+) GCCTA(A/T)CACGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST6GALNAC6 Gene

Variant ID Type Subtype PubMed ID
dgv497n21 CNV loss 19592680

Variation tolerance for ST6GALNAC6 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ST6GALNAC6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST6GALNAC6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST6GALNAC6 Gene

Disorders for ST6GALNAC6 Gene

Relevant External Links for ST6GALNAC6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ST6GALNAC6

No disorders were found for ST6GALNAC6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST6GALNAC6 Gene

Publications for ST6GALNAC6 Gene

  1. Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides. (PMID: 12668675) Tsuchida A. … Furukawa K. (J. Biol. Chem. 2003) 2 3 4 64
  2. Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers. (PMID: 17123352) Senda M. … Furukawa K. (Biochem. J. 2007) 3 4 64
  3. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. (PMID: 15843597) Harduin-Lepers A. … Oriol R. (Glycobiology 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for ST6GALNAC6 Gene

Sources for ST6GALNAC6 Gene

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