Aliases for ST6GALNAC6 Gene
Aliases for ST6GALNAC6 Gene
- ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 6 2 3 5
- Sialytransferase 7 ((Alpha-N-Acetylneuraminyl 2,3-Betagalactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialytransferase) F 2 3
- ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 6 2 3
- ST6 GalNAc Alpha-2,6-Sialyltransferase 6 2 3
- GalNAc Alpha-2,6-Sialyltransferase VI 3 4
- Sialyltransferase 7F 3 4
- ST6GALNACVI 3 4
- SIAT7-F 3 4
- SIAT7F 3 4
External Ids for ST6GALNAC6 Gene
- HGNC: 23364
- Entrez Gene: 30815
- Ensembl: ENSG00000160408
- OMIM: 610135
- UniProtKB: Q969X2
Previous HGNC Symbols for ST6GALNAC6 Gene
- SIAT7F
Previous GeneCards Identifiers for ST6GALNAC6 Gene
- GC09M122294
- GC09M124101
- GC09M126023
- GC09M127729
- GC09M129687
- GC09M130647
- GC09M100265
Summaries for ST6GALNAC6 Gene
-
ST6GALNAC6 belongs to a family of sialyltransferases that modify proteins and ceramides on the cell surface to alter cell-cell or cell-extracellular matrix interactions (Tsuchida et al., 2003 [PubMed 12668675]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ST6GALNAC6 Gene
ST6GALNAC6 (ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 6) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity and alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. An important paralog of this gene is ST6GALNAC5.
UniProtKB/Swiss-Prot for ST6GALNAC6 Gene
-
Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney. Participates in the synthesis of disialyl Lewis a (Le(a)).
Additional gene information for ST6GALNAC6 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST6GALNAC6 Gene
Genomics for ST6GALNAC6 Gene
GeneHancer (GH) Regulatory Elements for ST6GALNAC6 Gene
Promoters and enhancers for ST6GALNAC6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ST6GALNAC6 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ST6GALNAC6 Gene
Genomic Locations for ST6GALNAC6 Gene
- chr9:127,885,321-127,906,731
- (GRCh38/hg38)
- Size:
- 21,411 bases
- Orientation:
- Minus strand
- chr9:130,647,600-130,667,687
- (GRCh37/hg19)
Genomic View for ST6GALNAC6 Gene
Genes around ST6GALNAC6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q34.11 by Ensembl
- 9q34.11 by Entrez Gene
- 9q34.11 by HGNC
ST6GALNAC6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ST6GALNAC6 Gene
Proteins for ST6GALNAC6 Gene
-
Protein details for ST6GALNAC6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q969X2-SIA7F_HUMAN
- Recommended name:
- Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
- Protein Accession:
- Q969X2
- B3KQ01
- Q5T9C4
- Q5T9C5
- Q9H8A2
- Q9ULB8
Protein attributes for ST6GALNAC6 Gene
- Size:
- 333 amino acids
- Molecular mass:
- 38068 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- The carbohydrate antigen disialyl Lewis a, which is at least partly synthesized by ST6GALNAC6, is a normal counterpart of sialyl Lewis a, better known as CA19-9, an antigen widely used as a serum marker for diagnosis of cancers in the digestive track. Disialyl Lewis a is predominantly expressed in non-malignant epithelial cells of the digestive organs, while sialyl Lewis a is preferentially expressed in cancers. Disialyl Lewis a in normal epithelial cells serves as a ligand for immunosuppressive receptors, such as SIGLEC7 and SIGLEC9, expressed on resident monocytes/macrophages and maintains immunological homeostasis of mucosal membranes in digestive organs. Sialyl Lewis a, as well as its positional isomer sialyl Lewis x, serves as a ligand for vascular cell adhesion molecule E-selectin and facilitates hematogenous metastasis through mediating adhesion of circulating cancer cells to vascular endothelium (PubMed:17760270).
- SequenceCaution:
-
- Sequence=CAI12610.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12611.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW87712.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for ST6GALNAC6 Gene
Selected DME Specific Peptides for ST6GALNAC6 Gene
- Q969X2:
-
- HHRFITEKRVF
- HRFITEK
- LSTGWFT
- TVFIFWGP
- IRMNDAPT
Post-translational modifications for ST6GALNAC6 Gene
- Glycosylation at posLast=9898
Other Protein References for ST6GALNAC6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ST6GALNAC6
- Invitrogen Antibodies for ST6GALNAC6
- GeneTex ST6GALNAC6 antibody for ST6GALNAC6
Protein Products
- R&D Systems Proteins and Enzymes for ST6GALNAC6 (ST6 Sialyltransferase 6/ST6GALNAC6)
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ST6GALNAC6
- Origene Custom Protein Services for ST6GALNAC6
- antibodies-online: Search results for 8 available ST6GALNAC6 Proteins ranked by validation data
- Compare Top ST6GALNAC6 Proteins
-
Quality Products:
- Search GeneTex for Proteins for ST6GALNAC6
-
Abcam proteins for ST6GALNAC6
Assay Products
Domains & Families for ST6GALNAC6 Gene
Gene Families for ST6GALNAC6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for ST6GALNAC6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ST6GALNAC6 Gene
Graphical View of Domain Structure for InterPro Entry
Q969X2- Family:
-
- Belongs to the glycosyltransferase 29 family.
Function for ST6GALNAC6 Gene
Molecular function for ST6GALNAC6 Gene
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=0.33 mM for GM1b {ECO:0000269 PubMed:12668675}; KM=0.46 mM for sialyl-Lc4 {ECO:0000269 PubMed:12668675};
- UniProtKB/Swiss-Prot Function:
- Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney. Participates in the synthesis of disialyl Lewis a (Le(a)).
- UniProtKB/Swiss-Prot Induction:
- Down-regulated in renal cancers.
Enzyme Numbers (IUBMB) for ST6GALNAC6 Gene
Phenotypes From GWAS Catalog for ST6GALNAC6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity | ISS,TAS | -- |
| GO:0008373 | sialyltransferase activity | ISS | 12668675 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
Phenotypes for ST6GALNAC6 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ST6GALNAC6
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ST6GALNAC6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ST6GALNAC6 gene
- Search ViGene Biosciences for ST6GALNAC6
CRISPR Products
-
OriGene CRISPR knockouts for ST6GALNAC6
- genomics-online: gRNA clones - Search results for 117 available ST6GALNAC6 gene related products
- Overview of 117 available ST6GALNAC6 gene related products
-
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ST6GALNAC6
- GenScript: Design CRISPR guide RNA sequences for ST6GALNAC6
miRNA for ST6GALNAC6 Gene
- miRTarBase miRNAs that target ST6GALNAC6
miRNA Products
- Search ViGene Biosciences for ST6GALNAC6
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ST6GALNAC6
- Browse OriGene Inhibitory RNA Products For ST6GALNAC6
- genomics-online: shRNA clones - Search results for 117 available ST6GALNAC6 gene related products
- Overview of 117 available ST6GALNAC6 gene related products
-
Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for ST6GALNAC6 gene
Clone Products
- Sino Biological Human cDNA Clone for ST6GALNAC6
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- VectorBuilder custom plasmid, inducible vectors for ST6GALNAC6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ST6GALNAC6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 117 available ST6GALNAC6 gene related products
- Overview of 117 available ST6GALNAC6 gene related products
-
Recommended
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- Overview of 117 available ST6GALNAC6 gene related products
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Recommended
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ST6GALNAC6
-
ViGene Biosciences adenoviral particle packaged cDNA for ST6GALNAC6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ST6GALNAC6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ST6GALNAC6 gene
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ST6GALNAC6 Gene
Localization for ST6GALNAC6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ST6GALNAC6 Gene
- Golgi apparatus membrane; Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| golgi apparatus | 5 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005886 | plasma membrane | NAS | 10702226 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for ST6GALNAC6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Synthesis of substrates in N-glycan biosythesis | ||
| 2 | Glycosphingolipid biosynthesis - ganglio series | ||
| 3 | Metabolism of proteins | ||
| 4 | Metabolism | ||
| 5 | Transport to the Golgi and subsequent modification | ||
Pathways by source for ST6GALNAC6 Gene
2 BioSystems pathways for ST6GALNAC6 Gene
2 KEGG pathways for ST6GALNAC6 Gene
Interacting Proteins for ST6GALNAC6 Gene
Selected Interacting proteins:
Q969X2-SIA7F_HUMAN
ENSP00000291839
for ST6GALNAC6 Gene via
IID
STRING
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001574 | ganglioside biosynthetic process | ISS | -- |
| GO:0006486 | protein glycosylation | IEA | -- |
| GO:0006677 | glycosylceramide metabolic process | IDA | 17123352 |
| GO:0006687 | glycosphingolipid metabolic process | IDA | 17123352 |
| GO:0009100 | glycoprotein metabolic process | IDA | 17123352 |
No data available for SIGNOR curated interactions for ST6GALNAC6 Gene
Drugs & Compounds for ST6GALNAC6 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Disialosyl galactosyl globoside |
|
71764-07-3 |
|
Transcripts for ST6GALNAC6 Gene
mRNA/cDNA for ST6GALNAC6 Gene
- (18) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (583) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ST6GALNAC6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ST6GALNAC6
- genomics-online: gRNA clones - Search results for 117 available ST6GALNAC6 gene related products
- Overview of 117 available ST6GALNAC6 gene related products
-
Recommended
- Applied Biological Materials CRISPR for ST6GALNAC6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ST6GALNAC6
- GenScript: Design CRISPR guide RNA sequences for ST6GALNAC6
miRNA Products
- Search ViGene Biosciences for ST6GALNAC6
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ST6GALNAC6
- Browse OriGene Inhibitory RNA Products For ST6GALNAC6
- genomics-online: shRNA clones - Search results for 117 available ST6GALNAC6 gene related products
- Overview of 117 available ST6GALNAC6 gene related products
-
Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for ST6GALNAC6 gene
Clone Products
- Sino Biological Human cDNA Clone for ST6GALNAC6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ST6GALNAC6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ST6GALNAC6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 117 available ST6GALNAC6 gene related products
- Overview of 117 available ST6GALNAC6 gene related products
-
Recommended
- orf clones - Search results for 117 available ST6GALNAC6 gene related products
- Overview of 117 available ST6GALNAC6 gene related products
-
Recommended
- Applied Biological Materials Clones for ST6GALNAC6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f | · | 8g | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - |
Relevant External Links for ST6GALNAC6 Gene
- GeneLoc Exon Structure for
- ST6GALNAC6
- ECgene alternative splicing isoforms for
- ST6GALNAC6
Expression for ST6GALNAC6 Gene
This gene is overexpressed in Colon (19.7), Heart (14.9), Rectum (10.2), Synovial fluid (8.6), Fetal gut (8.0), and Monocytes (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ST6GALNAC6 Gene
NURSA nuclear receptor signaling pathways regulating expression of ST6GALNAC6 Gene:
ST6GALNAC6SOURCE GeneReport for Unigene cluster for ST6GALNAC6 Gene:
Hs.109672mRNA Expression by UniProt/SwissProt for ST6GALNAC6 Gene:
Q969X2-SIA7F_HUMAN
Tissue specificity:
Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines.
Evidence on tissue expression from TISSUES for ST6GALNAC6 Gene
- Nervous system(4.9)
- Muscle(4.4)
- Intestine(4.3)
- Thyroid gland(4.2)
Primer Products
-
OriGene qPCR primer pairs for ST6GALNAC6
- genomics-online: primer clones - Search results for 117 available ST6GALNAC6 gene related products
- Overview of 117 available ST6GALNAC6 gene related products
-
Recommended
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST6GALNAC6 Gene
Orthologs for ST6GALNAC6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ST6GALNAC6 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ST6GALNAC6 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ST6GALNAC6 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | St6galnac6 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | St6galnac6 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ST6GALNAC6 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ST6GALNAC6 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ST6GALNAC6 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ST6GALNAC6 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | st6galnac6 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | st6galnac6 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | ST6Gal 34 |
|
OneToMany |
- Species where no ortholog for ST6GALNAC6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ST6GALNAC6 Gene
- ENSEMBL:
- Gene Tree for ST6GALNAC6 (if available)
- TreeFam:
- Gene Tree for ST6GALNAC6 (if available)
Paralogs for ST6GALNAC6 Gene
Paralogs for ST6GALNAC6 Gene
(3) SIMAP similar genes for ST6GALNAC6 Gene using alignment to 2 proteins:
Variants for ST6GALNAC6 Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000209056 | -- | 127,897,743(-) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000224713 | -- | 127,900,931(-) | C/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000452293 | -- | 127,895,293(-) | C/T | intron_variant | |
| rs1000456356 | -- | 127,902,319(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000560336 | -- | 127,902,139(-) | T/A | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.19;
23.93% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ST6GALNAC6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ST6GALNAC6
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST6GALNAC6 Gene
Disorders for ST6GALNAC6 Gene
Additional Disease Information for ST6GALNAC6
No disorders were found for ST6GALNAC6 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST6GALNAC6 Gene
Publications for ST6GALNAC6 Gene
- Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides. (PMID: 12668675) Tsuchida A … Furukawa K (The Journal of biological chemistry 2003) 2 3 4 58
- Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers. (PMID: 17123352) Senda M … Furukawa K (The Biochemical journal 2007) 3 4 58
- The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. (PMID: 15843597) Harduin-Lepers A … Oriol R (Glycobiology 2005) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
Products for ST6GALNAC6 Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ST6GALNAC6
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- Abcam proteins for ST6GALNAC6
- Find your target
- Browse Primary Antibodies
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- Cloud-Clone Corp. disease models service
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- Invitrogen Antibodies for ST6GALNAC6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for ST6GALNAC6
- VectorBuilder custom plasmid, inducible vectors for ST6GALNAC6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ST6GALNAC6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
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- antibodies-online: Search results for 16 available ST6GALNAC6 Antibodies ranked by validation data
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- antibodies-online: Search results for available ST6GALNAC6 related products ranked by validation data
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- Quality Products:
- GeneTex ST6GALNAC6 antibody for ST6GALNAC6
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- ViGene Biosciences adenoviral particle packaged cDNA for ST6GALNAC6 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for ST6GALNAC6 gene
- Search ViGene Biosciences for ST6GALNAC6
- Browse Santa Cruz Biotechnology (SCBT) Antibodies
- Search Santa Cruz Biotechnology (SCBT) for ST6GALNAC6 siRNA/shRNA
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- Horizon Cell Lines for ST6GALNAC6
- genomics-online: cdna clones - Search results for 117 available ST6GALNAC6 gene related products
- Overview of 117 available ST6GALNAC6 gene related products
- Recommended
- orf clones - Search results for 117 available ST6GALNAC6 gene related products
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- genomics-online: gRNA clones - Search results for 117 available ST6GALNAC6 gene related products
- Overview of 117 available ST6GALNAC6 gene related products
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- genomics-online: primer clones - Search results for 117 available ST6GALNAC6 gene related products
- Overview of 117 available ST6GALNAC6 gene related products
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- genomics-online: shRNA clones - Search results for 117 available ST6GALNAC6 gene related products
- Overview of 117 available ST6GALNAC6 gene related products
- Recommended
Sources for ST6GALNAC6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew