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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ST6GALNAC6 Gene

protein-coding   GIFtS: 52
GCID: GC09M130647

ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide...

(Previous name: sialytransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl...)
(Previous symbol: SIAT7F)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ST6
(Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide
Alpha-2,6-Sialyltransferase 61 2
     RP11-203J24.32
SIAT7F1 2 3     ST6GALNACVI2
Sialytransferase 7 ((Alpha-N-Acetylneuraminyl
2,3-Betagalactosyl-1,3)-N-Acetyl Galactosaminide
Alpha-2,6-Sialytransferase) F1 2
     Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 62
GalNAc Alpha-2,6-Sialyltransferase VI2 3     CMP-NeuAC:(Beta)-N-Acetylgalactosaminide (Alpha)2,6-Sialyltransferase
Member VI2
Sialyltransferase 7F2 3     EC 2.4.99.-3
SIAT7-F2 3     ST6GalNAcVI3
HST6GalNAc VI2 3     EC 2.4.998
ST6GalNAc VI2 3     EC 2.4.99.78

External Ids:    HGNC: 233641   Entrez Gene: 308152   Ensembl: ENSG000001604087   OMIM: 6101355   UniProtKB: Q969X23   

Export aliases for ST6GALNAC6 gene to outside databases

Previous GC identifers: GC09M122294 GC09M124101 GC09M126023 GC09M127729 GC09M129687 GC09M100265


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ST6GALNAC6 Gene:
ST6GALNAC6 belongs to a family of sialyltransferases that modify proteins and ceramides on the cell surface to
alter cell-cell or cell-extracellular matrix interactions (Tsuchida et al., 2003 (PubMed 12668675)).(supplied by
OMIM, Mar 2008)

GeneCards Summary for ST6GALNAC6 Gene: 
ST6GALNAC6 (ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6) is a protein-coding gene. Diseases associated with ST6GALNAC6 include colon cancer, and among its related super-pathways are Glycosphingolipid biosynthesis - ganglio series and Metabolism. GO annotations related to this gene include alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity and sialyltransferase activity. An important paralog of this gene is ST6GALNAC3.

UniProtKB/Swiss-Prot: SIA7F_HUMAN, Q969X2
Function: Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward
GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG
(disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney.
Participates in the synthesis of disialyl Lewis a (Le(a))

Gene Wiki entry for ST6GALNAC6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ST6GALNAC6 gene promoter:
         MyoD   XBP-1   ATF6   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidST6GALNAC6 promoter sequence
   Search SABiosciences Chromatin IP Primers for ST6GALNAC6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST6GALNAC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.13

ST6GALNAC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST6GALNAC6 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M130647:  view genomic region     (about GC identifiers)

Start:
130,647,600 bp from pter      End:
130,667,687 bp from pter
Size:
20,088 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SIA7F_HUMAN, Q969X2 (See protein sequence)
Recommended Name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6  
Size: 333 amino acids; 38068 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Miscellaneous: The carbohydrate antigen disialyl Lewis a, which is at least partly synthesized by ST6GALNAC6, is a
normal counterpart of sialyl Lewis a, better known as CA19-9, an antigen widely used as a serum marker for
diagnosis of cancers in the digestive track. Disialyl Lewis a is predominantly expressed in non-malignant
epithelial cells of the digestive organs, while sialyl Lewis a is preferentially expressed in cancers. Disialyl
Lewis a in normal epithelial cells serves as a ligand for immunosuppressive receptors, such as SIGLEC7 and
SIGLEC9, expressed on resident monocytes/macrophages and maintains immunological homeostasis of mucosal membranes
in digestive organs. Sialyl Lewis a, as well as its positional isomer sialyl Lewis x, serves as a ligand for
vascular cell adhesion molecule E-selectin and facilitates hematogenous metastasis through mediating adhesion of
circulating cancer cells to vascular endothelium (PubMed:17760270)
Sequence caution: Sequence=CAI12610.1; Type=Erroneous gene model prediction; Sequence=CAI12611.1; Type=Erroneous
gene model prediction; Sequence=EAW87712.1; Type=Erroneous gene model prediction;
Secondary accessions: B3KQ01 Q5T9C4 Q5T9C5 Q9H8A2 Q9ULB8
Alternative splicing: 2 isoforms:  Q969X2-1   Q969X2-2   

Explore the universe of human proteins at neXtProt for ST6GALNAC6: NX_Q969X2

Explore proteomics data for ST6GALNAC6 at MOPED 

4/5 DME Specific Peptides for ST6GALNAC6 (Q969X2) (see all 5)
 HRFITEK  LSTGWFT  TVFIFWGP  IRMNDAPT 

ST6GALNAC6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

ST6GALNAC6 Protein Expression
REFSEQ proteins: NP_038471.2  
ENSEMBL proteins: 
 ENSP00000362239   ENSP00000362234   ENSP00000362235   ENSP00000362237   ENSP00000405326  
 ENSP00000291839   ENSP00000438109  

Human Recombinant Protein Products for ST6GALNAC6: 
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Novus Biologicals ST6GALNAC6 Proteins
Novus Biologicals ST6GALNAC6 Lysates
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Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000139Golgi membrane IEA--
GO:0005737cytoplasm ISS--
GO:0005794Golgi apparatus ----
GO:0005886plasma membrane NAS10702226
GO:0016021integral to membrane IEA--

ST6GALNAC6 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ST3G: Sialyltransferases

1 InterPro protein domain:
 IPR001675 Glyco_trans_29

Graphical View of Domain Structure for InterPro Entry Q969X2

ProtoNet protein and cluster: Q969X2

1 Blocks protein domain: IPB001675 Glycosyl transferase

UniProtKB/Swiss-Prot: SIA7F_HUMAN, Q969X2
Similarity: Belongs to the glycosyltransferase 29 family


ST6GALNAC6 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: SIA7F_HUMAN, Q969X2
Function: Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward
GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG
(disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney.
Participates in the synthesis of disialyl Lewis a (Le(a))
Biophysicochemical properties: Kinetic parameters: KM=0.33 mM for GM1b; KM=0.46 mM for sialyl-Lc4;
Induction: Down-regulated in renal cancers

     Enzyme Numbers (IUBMB): EC 2.4.99.-1 EC 2.4.992 EC 2.4.99.72

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001665alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity ISS--
GO:0008373sialyltransferase activity ISS12668675
     
ST6GALNAC6 for ontologies           About GeneDecksing


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miRNA
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SwitchGear 3'UTR luciferase reporter plasmidST6GALNAC6 3' UTR sequence
Inhib. RNA
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST6GALNAC6


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for ST6GALNAC6 About                                                                                                See pathways by source

SuperPathContained pathways About
1Ganglio Sphingolipid Metabolism
Glycosphingolipid biosynthesis - ganglio series0.53
Ganglio Sphingolipid Metabolism0.53
2Metabolism
Metabolic pathways0.40

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for ST6GALNAC6
    Ganglio Sphingolipid Metabolism



2         Kegg Pathways  (Kegg details for ST6GALNAC6):
    Glycosphingolipid biosynthesis - ganglio series
Metabolic pathways


ST6GALNAC6 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ST6GALNAC6

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for ST6GALNAC6 (Q969X23 ENSP000002918394) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ATXN1P542533, ENSP000002447694I2D: score=3 STRING: ENSP00000244769
MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
ST3GAL1ENSP000003184454STRING: ENSP00000318445
ST3GAL2ENSP000003454774STRING: ENSP00000345477
ST8SIA5ENSP000003213434STRING: ENSP00000321343
About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001574ganglioside biosynthetic process ISS--
GO:0006486protein glycosylation IEA--
GO:0006677glycosylceramide metabolic process IDA17123352
GO:0006687glycosphingolipid metabolic process IDA17123352
GO:0009100glycoprotein metabolic process IDA17123352

ST6GALNAC6 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ST6GALNAC6 (SIA7F)

1 HMDB Compound for ST6GALNAC6    About this table
CompoundSynonyms CAS #PubMed Ids
Disialosyl galactosyl globosideDisialosylgalactosylgloboside (see all 6)71764-07-3--

Search CenterWatch for drugs/clinical trials and news about ST6GALNAC6 / SIA7F

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ST6GALNAC6 gene: 
NM_013443.3  

Unigene Cluster for ST6GALNAC6:

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Hs.109672  [show with all ESTs]
Unigene Representative Sequence: BC036102
15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000373146(uc004bso.1) ENST00000373141(uc004bsn.1 uc011man.1)
ENST00000373142(uc004bsp.1) ENST00000373144(uc004bsq.1) ENST00000485320
ENST00000463086 ENST00000480417 ENST00000447681 ENST00000494541 ENST00000481355
ENST00000478319 ENST00000494611 ENST00000483353 ENST00000291839(uc004bsr.2 uc010mxp.1)
ENST00000542456
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SwitchGear 3'UTR luciferase reporter plasmidST6GALNAC6 3' UTR sequence
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Additional mRNA sequence: 

AB035173.1 AJ507293.1 AK023900.1 AK025959.1 AK057100.1 AK226174.1 AK300534.1 AK310850.1 
AY358672.1 BC006564.2 BC007802.2 BC016299.2 BC036102.1 CR457318.1 

24/29 DOTS entries (see all 29):

DT.115492  DT.91758063  DT.101984750  DT.100708143  DT.100708596  DT.95138277  DT.86851844  DT.100818793 
DT.100818790  DT.95138278  DT.121209803  DT.100829913  DT.91758062  DT.100818791  DT.100818795  DT.75176378 
DT.100778413  DT.121209889  DT.121209904  DT.121209938  DT.121209944  DT.121209960  DT.91758064  DT.95138280 

24/583 AceView cDNA sequences (see all 583):

AI884712 BG751833 CA420765 CR599905 AU098415 AJ507293 AI420202 BU956288 
AW963484 AB035173 AI471209 BI260659 BI966037 BQ072504 BP362196 BQ129959 
AU102582 CD365075 AA401021 BM547386 CA428733 BQ424678 BM982541 CA435785 

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC6 (see all 13)    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g ^ 9
SP1:                    -     -     -     -           -     -     -     -                                   -                                                   
SP2:                    -     -     -     -           -     -     -     -                                                                                       
SP3:                    -     -     -     -     -     -     -     -     -                                   -                                                   
SP4:                    -     -     -     -     -     -     -     -     -           -     -                 -                                                   
SP5:                                                                    -                                   -                                                   


ECgene alternative splicing isoforms for ST6GALNAC6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ST6GALNAC6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGGCCTTGGT
ST6GALNAC6 Expression
About this image


See ST6GALNAC6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ST6GALNAC6

SOURCE GeneReport for Unigene cluster: Hs.109672

UniProtKB/Swiss-Prot: SIA7F_HUMAN, Q969X2
Tissue specificity: Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines

    SABiosciences Custom PCR Arrays for ST6GALNAC6
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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST6GALNAC6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ST6GALNAC6 gene from 5/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia St6galnac61 , 5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more1, 5 89.79(n)1
93.09(a)1
  2 (22.09 cM)5
509351  NM_016973.21  NP_058669.11 
 325997095 
chicken
(Gallus gallus)
Aves ST6GALNAC61 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more 75.48(n)
75.25(a)
  425243  XM_423028.3  XP_423028.3 
lizard
(Anolis carolinensis)
Reptilia ST6GALNAC66
Uncharacterized protein
75(a)
1 ↔ 1
AAWZ02039308(984-3325)
zebrafish
(Danio rerio)
Actinopterygii st6galnac61 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more 63.89(n)
55.4(a)
  407715  XM_690185.5  XP_695277.4 
fruit fly
(Drosophila melanogaster)
Insecta ST6Gal6
Sialyltransferase
13(a)
1 → many
2R(20578945-20581909)


ENSEMBL Gene Tree for ST6GALNAC6 (if available)
TreeFam Gene Tree for ST6GALNAC6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ST6GALNAC6 gene
ST6GALNAC32  ST6GAL22  ST6GALNAC52  ST6GAL12  ST6GALNAC42  
3 SIMAP similar genes for ST6GALNAC6 using alignment to 2 protein entries:     SIA7F_HUMAN (see all proteins):
ST6GALNAC5    ST6GALNAC4    ST6GALNAC3

ST6GALNAC6 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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10/353 SNPs in ST6GALNAC6 are shown (see all 353)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs799672511,2
F--130660279(+) CAGACG/ACTTAA 1 -- int11Minor allele frequency- A:0.01WA 118
rs1424918311,2
C--130660559(+) CCGCAC/TGCCCC 1 -- int10--------
rs1459368391,2
--130660680(+) AAGACA/GTGGTC 1 -- int10--------
rs20316961,2
C,F,H--130660733(+) CCAGGC/TGACAC 1 -- int114Minor allele frequency- T:0.01NS NA WA CSA EA 887
rs1118063731,2
C--130660749(+) ACGAAC/G/TCCGGA 1 -- spd11CSA 1
rs31782431,2
C--130660750(-) CTCCGG/ACTTCG 1 -- spd12Minor allele frequency- A:0.00NA 4
rs10535201,2
C,F,H--130660864(-) GACCAG/AATGGA 1 -- ut31 ese33Minor allele frequency- A:0.01NS NA 290
rs1384144641,2
--130660871(+) GGTCCC/TTCCAG 1 -- ut310--------
rs1492452041,2
--130661028(+) CAGGAC/TGACAG 1 -- ut310--------
rs1445783221,2
--130661175(+) GCAGCG/TGGCTG 1 -- ut310--------

HapMap Linkage Disequilibrium report for ST6GALNAC6 (130647600 - 130667687 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for ST6GALNAC6:    About this table     
Variant IDTypeSubtypePubMed ID
dgv8291n71CNV Loss21882294
dgv8290n71CNV Loss21882294
nsv893865CNV Loss21882294
dgv8287n71CNV Loss21882294
dgv8293n71CNV Loss21882294
nsv893874CNV Loss21882294
dgv497n21CNV Loss19592680
nsv893859CNV Loss21882294
nsv893860CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 610135    OMIM disorders: --

2 diseases for ST6GALNAC6:    About MalaCards
colon cancer    


ST6GALNAC6 for disorders           About GeneDecksing


Export disorders for ST6GALNAC6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ST6GALNAC6 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with ST6GALNAC6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides. (PubMed id 12668675)1, 2, 3 Tsuchida A.... Furukawa K. (2003)
  2. Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers. (PubMed id 17123352)1, 2 Senda M....Furukawa K. (2007)
  3. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. (PubMed id 15843597)1, 2 Harduin-Lepers A.... Oriol R. (2005)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  6. Carbohydrate antigen sialyl Lewis a--its pathophysiological significance and induction mechanism in cancer progression. (PubMed id 17760270)2 Kannagi R. (2007)
  7. Identification of linkage-specific sequence motifs in sialyltransferases. (PubMed id 16207893)2 Patel R.Y. and Balaji P.V. (2006)
  8. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
  9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  10. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 30815 HGNC: 23364 AceView: AK1andSIAT7F Ensembl:ENSG00000160408 euGenes: HUgn30815
ECgene: ST6GALNAC6 Kegg: 30815 H-InvDB: ST6GALNAC6

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ST6GALNAC6 Pharmacogenomics, SNPs, Pathways
GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST6GALNAC6
Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_635

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ST6GALNAC6 gene:
Search GeneIP for patents involving ST6GALNAC6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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