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ST6GALNAC6 Gene

protein-coding   GIFtS: 54
GCID: GC09M130647

ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide...

(Previous name: sialytransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl...)
(Previous symbol: SIAT7F)
  See related disease
at
MalaCards
 

Aliases
for ST6GALNAC6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
ST6
(Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide
Alpha-2,6-Sialyltransferase 61 2
     CMP-NeuAC:(Beta)-N-Acetylgalactosaminide (Alpha)2,6-Sialyltransferase
Member VI2
SIAT7F1 2 3 5     EC 2.4.99.-3
Sialytransferase 7 ((Alpha-N-Acetylneuraminyl
2,3-Betagalactosyl-1,3)-N-Acetyl Galactosaminide
Alpha-2,6-Sialytransferase) F1 2
     ST6GalNAcVI3
GalNAc Alpha-2,6-Sialyltransferase VI2 3     HST6GalNAc VI3
Sialyltransferase 7F2 3     ST6GalNAc VI3
SIAT7-F2 3     EC 2.4.998
ST6GALNACVI2     EC 2.4.99.78
Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 62     

External Ids:    HGNC: 233641   Entrez Gene: 308152   Ensembl: ENSG000001604087   OMIM: 6101355   UniProtKB: Q969X23   
ORGUL members:         

Export aliases for ST6GALNAC6 gene to outside databases

Previous GC identifers: GC09M122294 GC09M124101 GC09M126023 GC09M127729 GC09M129687 GC09M100265


Summaries
for ST6GALNAC6 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ST6GALNAC6 Gene:
ST6GALNAC6 belongs to a family of sialyltransferases that modify proteins and ceramides on the cell surface to
alter cell-cell or cell-extracellular matrix interactions (Tsuchida et al., 2003 (PubMed 12668675)).(supplied by
OMIM, Mar 2008)

GeneCards Summary for ST6GALNAC6 Gene:
ST6GALNAC6 (ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6) is a protein-coding gene. Diseases associated with ST6GALNAC6 include ataxia. GO annotations related to this gene include alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity and sialyltransferase activity. An important paralog of this gene is ST6GALNAC3.

UniProtKB/Swiss-Prot: SIA7F_HUMAN, Q969X2
Function: Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward
GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG
(disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney.
Participates in the synthesis of disialyl Lewis a (Le(a))

Gene Wiki entry for ST6GALNAC6 Gene


Genomic Views
for ST6GALNAC6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ST6GALNAC6 gene promoter:
         MyoD   XBP-1   ATF6   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ST6GALNAC6 promoter sequence
   Search Chromatin IP Primers for ST6GALNAC6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST6GALNAC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.13

ST6GALNAC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST6GALNAC6 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M130647:  view genomic region     (about GC identifiers)

Start:
 130,647,600 bp from pter      End:
 130,667,687 bp from pter
Size:
 20,088 bases      Orientation:
 minus strand

Proteins
for ST6GALNAC6 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SIA7F_HUMAN, Q969X2 (See protein sequence)
Recommended Name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6  
Size: 333 amino acids; 38068 Da
Miscellaneous: The carbohydrate antigen disialyl Lewis a, which is at least partly synthesized by ST6GALNAC6, is a
normal counterpart of sialyl Lewis a, better known as CA19-9, an antigen widely used as a serum marker for
diagnosis of cancers in the digestive track. Disialyl Lewis a is predominantly expressed in non-malignant
epithelial cells of the digestive organs, while sialyl Lewis a is preferentially expressed in cancers. Disialyl
Lewis a in normal epithelial cells serves as a ligand for immunosuppressive receptors, such as SIGLEC7 and
SIGLEC9, expressed on resident monocytes/macrophages and maintains immunological homeostasis of mucosal membranes
in digestive organs. Sialyl Lewis a, as well as its positional isomer sialyl Lewis x, serves as a ligand for
vascular cell adhesion molecule E-selectin and facilitates hematogenous metastasis through mediating adhesion of
circulating cancer cells to vascular endothelium (PubMed:17760270)
Sequence caution: Sequence=CAI12610.1; Type=Erroneous gene model prediction; Sequence=CAI12611.1; Type=Erroneous
gene model prediction; Sequence=EAW87712.1; Type=Erroneous gene model prediction;
Secondary accessions: B3KQ01 Q5T9C4 Q5T9C5 Q9H8A2 Q9ULB8
Alternative splicing: 2 isoforms:  Q969X2-1   Q969X2-2   

Explore the universe of human proteins at neXtProt for ST6GALNAC6: NX_Q969X2

Explore proteomics data for ST6GALNAC6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn98
  • Modification sites at PhosphoSitePlus
    • Selected DME Specific Peptides for ST6GALNAC6 (Q969X2) (see all 5)
     HRFITEK  LSTGWFT  TVFIFWGP  IRMNDAPT 


    See ST6GALNAC6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001273928.1  NP_001273929.1  NP_001273930.1  NP_001273931.1  NP_001273932.1  NP_038471.2  

    ENSEMBL proteins: 
     ENSP00000362239   ENSP00000362234   ENSP00000362235   ENSP00000362237   ENSP00000405326  
     ENSP00000291839   ENSP00000438109  
    Reactome Protein details: Q969X2

    ST6GALNAC6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ST6GALNAC6 (ST6 Sialyltransferase 6/ST6GALNAC6)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ST6GALNAC6
    GenScript Custom Purified and Recombinant Proteins Services for ST6GALNAC6
    Novus Biologicals ST6GALNAC6 Proteins
    Novus Biologicals ST6GALNAC6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    ST6GALNAC6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ST6GALNAC6
    Novus Biologicals ST6GALNAC6 Antibodies
    Abcam antibodies for ST6GALNAC6
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for ST6GALNAC6
    LSBio Antibodies in human, mouse, rat for ST6GALNAC6

    ST6GALNAC6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ST6GALNAC6
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    GenScript Custom Assay Services for ST6GALNAC6
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.

    Domains /
    Families
    for ST6GALNAC6 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    ST3G: Sialyltransferases

    1 InterPro protein domain:
     IPR001675 Glyco_trans_29

    Graphical View of Domain Structure for InterPro Entry Q969X2

    ProtoNet protein and cluster: Q969X2

    1 Blocks protein domain: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIA7F_HUMAN, Q969X2
    Similarity: Belongs to the glycosyltransferase 29 family


    ST6GALNAC6 for domains           About GeneDecksing


    Function
    for ST6GALNAC6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIA7F_HUMAN, Q969X2
    Function: Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward
    GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG
    (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney.
    Participates in the synthesis of disialyl Lewis a (Le(a))
    Biophysicochemical properties: Kinetic parameters: KM=0.33 mM for GM1b; KM=0.46 mM for sialyl-Lc4;
    Induction: Down-regulated in renal cancers

         Enzyme Numbers (IUBMB): EC 2.4.99.-1 EC 2.4.992 EC 2.4.99.72

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001665alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity ISS--
    GO:0008373sialyltransferase activity ISS12668675
         
    ST6GALNAC6 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ST6GALNAC6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ST6GALNAC6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ST6GALNAC6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ST6GALNAC6

    miRNA
    Products:            		Block miRNA regulation of human, mouse, rat ST6GALNAC6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ST6GALNAC6 (see all 32):
    hsa-miR-142-5p hsa-miR-125a-5p hsa-miR-520d-5p hsa-miR-106a hsa-miR-10b hsa-miR-605 hsa-miR-486-3p hsa-miR-486-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ST6GALNAC6 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for ST6GALNAC6
    Predesigned siRNA for gene silencing in human, mouse, rat ST6GALNAC6

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ST6GALNAC6

    Clone
    Products:             		 OriGene clones in human, mouse for ST6GALNAC6 (see all 10)
    OriGene ORF clones in mouse, rat for ST6GALNAC6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ST6GALNAC6 (NM_013443)
    Sino Biological Human cDNA Clone for ST6GALNAC6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST6GALNAC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST6GALNAC6

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ST6GALNAC6
    Browse ESI BIO Cell Lines and PureStem Progenitors for ST6GALNAC6 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST6GALNAC6


    Localization
    for ST6GALNAC6 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Subcellular locations from UniProtKB/Swiss-Prot
    SIA7F_HUMAN, Q969X2: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    plasma membrane4
    endoplasmic reticulum1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005737cytoplasm ISS--
    GO:0005794Golgi apparatus ----
    GO:0005886plasma membrane NAS10702226
    GO:0016021integral component of membrane IEA--

    ST6GALNAC6 for ontologies           About GeneDecksing


    Pathways & Interactions
    for ST6GALNAC6 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

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    SuperPaths for ST6GALNAC6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glycosphingolipid biosynthesis - ganglio series
    		Ganglio Sphingolipid Metabolism0.53
    		Glycosphingolipid biosynthesis - ganglio series0.53
    2Metabolism
    		Metabolic pathways0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ST6GALNAC6
        Ganglio Sphingolipid Metabolism


    1 Reactome Pathway for ST6GALNAC6
        Sialic acid metabolism


    2 Kegg Pathways  (Kegg details for ST6GALNAC6):
        Glycosphingolipid biosynthesis - ganglio series
    Metabolic pathways


    ST6GALNAC6 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ST6GALNAC6
    Interactions:

        Search GeneGlobe Interaction Network for ST6GALNAC6

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for ST6GALNAC6 (Q969X23 ENSP000002918394) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542533, ENSP000002447694I2D: score=3 STRING: ENSP00000244769
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    ST3GAL1ENSP000003184454STRING: ENSP00000318445
    ST3GAL2ENSP000003454774STRING: ENSP00000345477
    ST8SIA5ENSP000003213434STRING: ENSP00000321343
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001574ganglioside biosynthetic process ISS--
    GO:0006486protein glycosylation IEA--
    GO:0006677glycosylceramide metabolic process IDA17123352
    GO:0006687glycosphingolipid metabolic process IDA17123352
    GO:0009100glycoprotein metabolic process IDA17123352

    ST6GALNAC6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ST6GALNAC6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ST6GALNAC6 (SIA7F)

    1 HMDB Compound for ST6GALNAC6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Disialosyl galactosyl globosideDisialosylgalactosylgloboside (see all 6)71764-07-3--



    Transcripts
    for ST6GALNAC6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for ST6GALNAC6 gene (6 alternative transcripts): 
    NM_001286999.1  NM_001287000.1  NM_001287001.1  NM_001287002.1  NM_001287003.1  NM_013443.4  

    Unigene Cluster for ST6GALNAC6:

    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
    Hs.109672  [show with all ESTs]
    Unigene Representative Sequence: BC036102
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373146(uc004bso.1) ENST00000373141(uc004bsn.1 uc011man.1)
    ENST00000373142(uc004bsp.1) ENST00000373144(uc004bsq.1) ENST00000485320
    ENST00000463086 ENST00000480417 ENST00000447681 ENST00000494541 ENST00000481355
    ENST00000478319 ENST00000494611 ENST00000483353 ENST00000291839(uc004bsr.2 uc010mxp.1)
    ENST00000542456
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ST6GALNAC6 (see all 32):
    hsa-miR-142-5p hsa-miR-125a-5p hsa-miR-520d-5p hsa-miR-106a hsa-miR-10b hsa-miR-605 hsa-miR-486-3p hsa-miR-486-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ST6GALNAC6 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for ST6GALNAC6
    Predesigned siRNA for gene silencing in human, mouse, rat ST6GALNAC6
    Clone
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    GenScript: all cDNA clones in your preferred vector: ST6GALNAC6 (NM_013443)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST6GALNAC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST6GALNAC6
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ST6GALNAC6
      QuantiTect SYBR Green Assays in human, mouse, rat ST6GALNAC6
      QuantiFast Probe-based Assays in human, mouse, rat ST6GALNAC6

    Additional mRNA sequence: 

    AB035173.1 AJ507293.1 AK023900.1 AK025959.1 AK057100.1 AK226174.1 AK300534.1 AK310850.1 
    AY358672.1 BC006564.2 BC007802.2 BC016299.2 BC036102.1 CR457318.1 

    Selected DOTS entries (see all 29):

    DT.115492  DT.91758063  DT.101984750  DT.100708143  DT.100708596  DT.95138277  DT.86851844  DT.100818793 
    DT.100818790  DT.95138278  DT.121209803  DT.100829913  DT.91758062  DT.100818791  DT.100818795  DT.75176378 
    DT.100778413  DT.121209889  DT.121209904  DT.121209938  DT.121209944  DT.121209960  DT.91758064  DT.95138280 

    Selected AceView cDNA sequences (see all 583):

    AI884712 BG751833 CA420765 CR599905 AU098415 BQ424678 BM982541 CA435785 
    BM991282 BU856356 BM999325 AI686021 BU167789 BX119193 BM662468 BE313808 
    AI833295 AI341125 BM739235 BM141809 BI838391 AW294326 BP362195 AA631095 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC6 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g ^ 9
    SP1:                    -     -     -     -           -     -     -     -                                   -                                                   
    SP2:                    -     -     -     -           -     -     -     -                                                                                       
    SP3:                    -     -     -     -     -     -     -     -     -                                   -                                                   
    SP4:                    -     -     -     -     -     -     -     -     -           -     -                 -                                                   
    SP5:                                                                    -                                   -                                                   


    ECgene alternative splicing isoforms for ST6GALNAC6

    Expression
    for ST6GALNAC6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ST6GALNAC6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGCCTTGGT
    ST6GALNAC6 Expression
    About this image

    ST6GALNAC6 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    ST6GALNAC6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.109672

    UniProtKB/Swiss-Prot: SIA7F_HUMAN, Q969X2
    Tissue specificity: Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines

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    Orthologs
    for ST6GALNAC6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ST6GALNAC6 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia St6galnac61 , 5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more1, 5 89.79(n)1
    93.09(a)1    		   2 (22.09 cM)5
    509351  NM_016973.21  NP_058669.11 
     325997095 
    chicken
    (Gallus gallus)    		 Aves ST6GALNAC61 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more 75.48(n)
    75.25(a)    		   425243  XM_423028.4  XP_423028.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ST6GALNAC66
    		 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl...
    		 73(a)
    		 1 ↔ 1
    		 AAWZ02039308(984-3325)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia st6galnac61 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more 65.43(n)
    65.2(a)    		   100329192  NM_001171831.1  NP_001165302.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii st6galnac61 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more 63.31(n)
    54.21(a)    		   407715  XM_690185.6  XP_695277.5 
    fruit fly
    (Drosophila melanogaster)    		 Insecta ST6Gal6
    		 Sialyltransferase
    		 12(a)
    		 1 → many
    		 2R(20578945-20581909)


    ENSEMBL Gene Tree for ST6GALNAC6 (if available)
    TreeFam Gene Tree for ST6GALNAC6 (if available)

    Paralogs
    for ST6GALNAC6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ST6GALNAC6 gene
    ST6GALNAC32  ST6GAL22  ST6GALNAC52  ST6GAL12  ST6GALNAC42  
    3 SIMAP similar genes for ST6GALNAC6 using alignment to 2 protein entries:     SIA7F_HUMAN (see all proteins):
    ST6GALNAC5    ST6GALNAC4    ST6GALNAC3

    ST6GALNAC6 for paralogs           About GeneDecksing



    Genomic Variants
    for ST6GALNAC6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ST6GALNAC6 (see all 353)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs799672511,2
    		F--130660279(+) CAGACG/ACTTAA 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1424918311,2
    		C--130660559(+) CCGCAC/TGCCCC 1 -- int10--------
    rs1459368391,2
    		--130660680(+) AAGACA/GTGGTC 1 -- int10--------
    rs20316961,2
    		C,F,H--130660733(+) CCAGGC/TGACAC 1 -- int114Minor allele frequency- T:0.01NS NA WA CSA EA 887
    rs1118063731,2
    		C--130660749(+) ACGAAC/G/TCCGGA 1 -- spd11CSA 1
    rs31782431,2
    		C--130660750(-) CTCCGG/ACTTCG 1 -- spd12Minor allele frequency- A:0.00NA 4
    rs10535201,2
    		C,F,H--130660864(-) GACCAG/AATGGA 1 -- ut31 ese33Minor allele frequency- A:0.01NS NA 290
    rs1384144641,2
    		--130660871(+) GGTCCC/TTCCAG 1 -- ut310--------
    rs1492452041,2
    		--130661028(+) CAGGAC/TGACAG 1 -- ut310--------
    rs1445783221,2
    		--130661175(+) GCAGCG/TGGCTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ST6GALNAC6 (130647600 - 130667687 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ST6GALNAC6:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv8291n71CNV Loss21882294
    dgv8290n71CNV Loss21882294
    nsv893865CNV Loss21882294
    dgv8287n71CNV Loss21882294
    dgv8293n71CNV Loss21882294
    nsv893874CNV Loss21882294
    dgv497n21CNV Loss19592680
    nsv893859CNV Loss21882294
    nsv893860CNV Gain21882294

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    Disorders / Diseases
    for ST6GALNAC6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 OMIM gene information: 610135    OMIM disorders: --

    1 disease for ST6GALNAC6:    About MalaCards
    ataxia


    ST6GALNAC6 for disorders           About GeneDecksing


    Export disorders for ST6GALNAC6 gene to outside databases

    Publications
    for ST6GALNAC6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ST6GALNAC6 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with ST6GALNAC6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides. (PubMed id 12668675)1, 2, 3 Tsuchida A.... Furukawa K. (J. Biol. Chem. 2003)
    2. Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers. (PubMed id 17123352)1, 2 Senda M.... Furukawa K. (Biochem. J. 2007)
    3. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. (PubMed id 15843597)1, 2 Harduin-Lepers A.... Oriol R. (Glycobiology 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Carbohydrate antigen sialyl Lewis a - its pathophysiological significance and induction mechanism in cancer progression. (PubMed id 17760270)2 Kannagi R. (Chang Gung Med. J. 2007)
    7. Identification of linkage-specific sequence motifs in sialyltransferases. (PubMed id 16207893)2 Patel R.Y. and Balaji P.V. (Glycobiology 2006)
    8. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (Cell 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (Nature 2004)

    External Searches for ST6GALNAC6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ST6GALNAC6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 30815 HGNC: 23364 AceView: AK1andSIAT7F Ensembl:ENSG00000160408 euGenes: HUgn30815
    ECgene: ST6GALNAC6 Kegg: 30815 H-InvDB: ST6GALNAC6

    Other Databases showing ST6GALNAC6 gene

    (According to HUGE)
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    Specialized Databases showing ST6GALNAC6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ST6GALNAC6 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST6GALNAC6
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_635

    Intellectual Property
    for ST6GALNAC6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for ST6GALNAC6 gene:
    Search GeneIP for patents involving ST6GALNAC6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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