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ST6GALNAC6 Gene

protein-coding GIFtS: 54
GCID: GC09M130647

ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide...

(Previous name: sialytransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl...)
(Previous symbol: SIAT7F)

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disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 6¹ ²		CMP-NeuAC:(Beta)-N-Acetylgalactosaminide (Alpha)2,6-Sialyltransferase Member VI²
SIAT7F¹ ² ³ ⁵		EC 2.4.99.-³
Sialytransferase 7 ((Alpha-N-Acetylneuraminyl 2,3-Betagalactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialytransferase) F¹ ²		ST6GalNAcVI³
GalNAc Alpha-2,6-Sialyltransferase VI² ³		HST6GalNAc VI³
Sialyltransferase 7F² ³		ST6GalNAc VI³
SIAT7-F² ³		EC 2.4.99⁸
ST6GALNACVI²		EC 2.4.99.7⁸
Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 6²

External Ids:	HGNC: 23364¹	Entrez Gene: 30815²	Ensembl: ENSG00000160408⁷	OMIM: 610135⁵	UniProtKB: Q969X2³

ORGUL members:

Export aliases for ST6GALNAC6 gene to outside databases

Previous GC identifers: GC09M122294 GC09M124101 GC09M126023 GC09M127729 GC09M129687 GC09M100265

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ST6GALNAC6 Gene:

ST6GALNAC6 belongs to a family of sialyltransferases that modify proteins and ceramides on the cell surface to

alter cell-cell or cell-extracellular matrix interactions (Tsuchida et al., 2003 (PubMed 12668675)).(supplied by

OMIM, Mar 2008)

GeneCards Summary for ST6GALNAC6 Gene:

ST6GALNAC6 (ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6) is a protein-coding gene. GO annotations related to this gene include alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity and sialyltransferase activity. An important paralog of this gene is ST6GALNAC3.

UniProtKB/Swiss-Prot: SIA7F_HUMAN, Q969X2

Function: Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward

GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG

(disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney.

Participates in the synthesis of disialyl Lewis a (Le(a))

Gene Wiki entry for ST6GALNAC6 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000009.11 NT_008470.20 NC_018920.2

Regulatory elements:

Regulatory transcription factor binding sites in the ST6GALNAC6 gene promoter:
MyoD XBP-1 ATF6 E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ST6GALNAC6 promoter sequence

Search Chromatin IP Primers for ST6GALNAC6

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST6GALNAC6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q34.13

ST6GALNAC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST6GALNAC6 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M130647: view genomic region (about GC identifiers)

Start:	130,647,600 bp from pter	End:	130,667,687 bp from pter
Size:	20,088 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: SIA7F_HUMAN, Q969X2 (See protein sequence)

Recommended Name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

Size: 333 amino acids; 38068 Da

Miscellaneous: The carbohydrate antigen disialyl Lewis a, which is at least partly synthesized by ST6GALNAC6, is a

normal counterpart of sialyl Lewis a, better known as CA19-9, an antigen widely used as a serum marker for

diagnosis of cancers in the digestive track. Disialyl Lewis a is predominantly expressed in non-malignant

epithelial cells of the digestive organs, while sialyl Lewis a is preferentially expressed in cancers. Disialyl

Lewis a in normal epithelial cells serves as a ligand for immunosuppressive receptors, such as SIGLEC7 and

SIGLEC9, expressed on resident monocytes/macrophages and maintains immunological homeostasis of mucosal membranes

in digestive organs. Sialyl Lewis a, as well as its positional isomer sialyl Lewis x, serves as a ligand for

vascular cell adhesion molecule E-selectin and facilitates hematogenous metastasis through mediating adhesion of

circulating cancer cells to vascular endothelium (PubMed:17760270)

Sequence caution: Sequence=CAI12610.1; Type=Erroneous gene model prediction; Sequence=CAI12611.1; Type=Erroneous

gene model prediction; Sequence=EAW87712.1; Type=Erroneous gene model prediction;

Secondary accessions: B3KQ01 Q5T9C4 Q5T9C5 Q9H8A2 Q9ULB8

Alternative splicing: 2 isoforms: Q969X2-1 Q969X2-2

Explore the universe of human proteins at neXtProt for ST6GALNAC6: NX_Q969X2

Explore proteomics data for ST6GALNAC6 at MOPED

Post-translational modifications:

Glycosylation² at Asn98

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for ST6GALNAC6 (Q969X2) (see all 5)

HRFITEK

LSTGWFT

TVFIFWGP

IRMNDAPT

See ST6GALNAC6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (6 alternative transcripts):

NP_001273928.1 NP_001273929.1 NP_001273930.1 NP_001273931.1 NP_001273932.1 NP_038471.2

ENSEMBL proteins:

ENSP00000362239 ENSP00000362234 ENSP00000362235 ENSP00000362237 ENSP00000405326

ENSP00000291839 ENSP00000438109

Reactome Protein details: Q969X2

ST6GALNAC6 Human Recombinant Protein Products:

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	antibodies-online proteins for ST6GALNAC6 (7 products)
	antibodies-online peptides for ST6GALNAC6

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:

ST3G: Sialyltransferases

1 InterPro protein domain:

IPR001675 Glyco_trans_29

Graphical View of Domain Structure for InterPro Entry Q969X2

ProtoNet protein and cluster: Q969X2

1 Blocks protein domain: IPB001675 Glycosyl transferase

UniProtKB/Swiss-Prot: SIA7F_HUMAN, Q969X2

Similarity: Belongs to the glycosyltransferase 29 family

Find genes that share domains with ST6GALNAC6 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SIA7F_HUMAN, Q969X2

Function: Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward

GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG

(disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney.

Participates in the synthesis of disialyl Lewis a (Le(a))

Biophysicochemical properties: Kinetic parameters: KM=0.33 mM for GM1b; KM=0.46 mM for sialyl-Lc4;

Induction: Down-regulated in renal cancers

Enzyme Numbers (IUBMB): EC 2.4.99.-¹ EC 2.4.99² EC 2.4.99.7²

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	ISS	--
GO:0008373	sialyltransferase activity	ISS	12668675

Find genes that share ontologies with ST6GALNAC6 About GenesLikeMe

Animal Models:

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST6GALNAC6

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

SIA7F_HUMAN, Q969X2: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
golgi apparatus	5
plasma membrane	4
endoplasmic reticulum	1
lysosome	1
mitochondrion	1

About this image

Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005737	cytoplasm	ISS	--
GO:0005794	Golgi apparatus	--	--
GO:0005886	plasma membrane	NAS	10702226
GO:0016021	integral component of membrane	IEA	--

Find genes that share ontologies with ST6GALNAC6 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for ST6GALNAC6 About

See pathways by source

Powered
by

SuperPath

Contained pathways About

Glycosphingolipid biosynthesis - ganglio series

Ganglio Sphingolipid Metabolism

0.53

Glycosphingolipid biosynthesis - ganglio series

0.53

Metabolism

Metabolic pathways

0.38

Find genes that share SuperPaths with ST6GALNAC6 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 BioSystems Pathway for ST6GALNAC6

Ganglio Sphingolipid Metabolism

1 Reactome Pathway for ST6GALNAC6

Sialic acid metabolism

2 Kegg Pathways (Kegg details for ST6GALNAC6):

	Glycosphingolipid biosynthesis - ganglio series
	Metabolic pathways

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for ST6GALNAC6
Interactions:

Search GeneGlobe Interaction Network for ST6GALNAC6

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for ST6GALNAC6 (Q969X2³ ENSP00000291839⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATXN1	P54253³, ENSP00000244769⁴	I2D: score=3 STRING: ENSP00000244769
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207
ST3GAL1	ENSP00000318445⁴	STRING: ENSP00000318445
ST3GAL2	ENSP00000345477⁴	STRING: ENSP00000345477
ST8SIA5	ENSP00000321343⁴	STRING: ENSP00000321343

About this table

Gene Ontology (GO): Selected biological process terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001574	ganglioside biosynthetic process	ISS	--
GO:0006486	protein glycosylation	IEA	--
GO:0006677	glycosylceramide metabolic process	IDA	17123352
GO:0006687	glycosphingolipid metabolic process	IDA	17123352
GO:0009100	glycoprotein metabolic process	IDA	17123352

Find genes that share ontologies with ST6GALNAC6 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for ST6GALNAC6 (SIA7F)

1 HMDB Compound for ST6GALNAC6 About this table

Compound	Synonyms	CAS #	PubMed Ids
Disialosyl galactosyl globoside	Disialosylgalactosylgloboside (see all 6)	71764-07-3	--

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for ST6GALNAC6 gene (12 alternative transcripts):

NM_001286999.1 NM_001287000.1 NM_001287001.1 NM_001287002.1 NM_001287003.1 NM_013443.4 XM_005251952.1 XM_006717088.1

XM_006717089.1 XM_006717090.1 XM_006717091.1 XM_006717092.1

Unigene Cluster for ST6GALNAC6:

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

Hs.109672 [show with all ESTs]

Unigene Representative Sequence: BC036102

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000373146(uc004bso.1) ENST00000373141(uc004bsn.1 uc011man.1)

ENST00000373142(uc004bsp.1) ENST00000373144(uc004bsq.1) ENST00000485320

ENST00000463086 ENST00000480417 ENST00000447681 ENST00000494541 ENST00000481355

ENST00000478319 ENST00000494611 ENST00000483353 ENST00000291839(uc004bsr.2 uc010mxp.1)

ENST00000542456

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Additional mRNA sequence:

AB035173.1 AJ507293.1 AK023900.1 AK025959.1 AK057100.1 AK226174.1 AK300534.1 AK310850.1

AY358672.1 BC006564.2 BC007802.2 BC016299.2 BC036102.1 CR457318.1

Selected DOTS entries (see all 29):

DT.115492 DT.91758063 DT.101984750 DT.100708143 DT.100708596 DT.95138277 DT.86851844 DT.100818793

DT.100818790 DT.95138278 DT.121209803 DT.100829913 DT.91758062 DT.100818791 DT.100818795 DT.75176378

DT.100778413 DT.121209889 DT.121209904 DT.121209938 DT.121209944 DT.121209960 DT.91758064 DT.95138280

Selected AceView cDNA sequences (see all 583):

AI884712 BG751833 CA420765 CR599905 AU098415 BQ424678 BM982541 CA435785

BM991282 BU856356 BM999325 AI686021 BU167789 BX119193 BM662468 BE313808

AI833295 AI341125 BM739235 BM141809 BI838391 AW294326 BP362195 AA631095

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC6 (see all 13) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	·	6c	·	6d	^	7	^	8a	·	8b	·	8c	·	8d	·	8e	·	8f	·	8g	^	9
SP1:							-		-		-		-				-		-		-		-												-
SP2:							-		-		-		-				-		-		-		-
SP3:							-		-		-		-		-		-		-		-		-												-
SP4:							-		-		-		-		-		-		-		-		-				-		-						-
SP5:																							-												-

ECgene alternative splicing isoforms for ST6GALNAC6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ST6GALNAC6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGGCCTTGGT

About this image

ST6GALNAC6 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ST6GALNAC6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.109672

UniProtKB/Swiss-Prot: SIA7F_HUMAN, Q969X2

Tissue specificity: Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines

Custom PCR Arrays for ST6GALNAC6

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ST6GALNAC6 gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	St6galnac6^{1 , 5}	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more^{1, 5}	89.79(n)¹ 93.09(a)¹		2 (22.09 cM)⁵ 50935¹ NM_016973.2¹ NP_058669.1¹ 32599709⁵
chicken (Gallus gallus)	Aves	ST6GALNAC6¹	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more	75.48(n) 75.25(a)		425243 XM_423028.4 XP_423028.3
lizard (Anolis carolinensis)	Reptilia	ST6GALNAC6⁶	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl...	73(a)	1 ↔ 1	AAWZ02039308(984-3325)
tropical clawed frog (Xenopus tropicalis)	Amphibia	st6galnac6¹	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more	65.43(n) 65.2(a)		100329192 NM_001171831.1 NP_001165302.1
zebrafish (Danio rerio)	Actinopterygii	st6galnac6¹	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more	63.31(n) 54.21(a)		407715 XM_690185.6 XP_695277.5
fruit fly (Drosophila melanogaster)	Insecta	ST6Gal⁶	Sialyltransferase	12(a)	1 → many	2R(20578945-20581909)

ENSEMBL Gene Tree for ST6GALNAC6 (if available)
TreeFam Gene Tree for ST6GALNAC6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for ST6GALNAC6 gene

ST6GALNAC3² ST6GAL2² ST6GALNAC5² ST6GAL1² ST6GALNAC4²

3 SIMAP similar genes for ST6GALNAC6 using alignment to 2 protein entries: SIA7F_HUMAN (see all proteins):

ST6GALNAC5 ST6GALNAC4 ST6GALNAC3

Find genes that share paralogs with ST6GALNAC6 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79967251^1,2	F	--	130660279(+)	`CAGACG/ACTTAA`	1	--	int¹		1		WA	118
rs142491831^1,2	C	--	130660559(+)	`CCGCAC/TGCCCC`	1	--	int¹		0	--	--	--	--
rs145936839^1,2		--	130660680(+)	`AAGACA/GTGGTC`	1	--	int¹		0	--	--	--	--
rs2031696^1,2	C,F,H	--	130660733(+)	`CCAGGC/TGACAC`	1	--	int¹		14		NS NA WA CSA EA	887
rs111806373^1,2	C	--	130660749(+)	`ACGAAC/G/TCCGGA`	1	--	spd¹		1		CSA	1
rs3178243^1,2	C	--	130660750(-)	`CTCCGG/ACTTCG`	1	--	spd¹		2		NA	4
rs1053520^1,2	C,F,H	--	130660864(-)	`GACCAG/AATGGA`	1	--	ut3¹ ese³		3		NS NA	290
rs138414464^1,2		--	130660871(+)	`GGTCCC/TTCCAG`	1	--	ut3¹		0	--	--	--	--
rs149245204^1,2		--	130661028(+)	`CAGGAC/TGACAG`	1	--	ut3¹		0	--	--	--	--
rs144578322^1,2		--	130661175(+)	`GCAGCG/TGGCTG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ST6GALNAC6 (130647600 - 130667687 bp)

Structural Variations
Database of Genomic Variants (DGV) 9 variations for ST6GALNAC6: About this table

Variant ID	Type	Subtype	PubMed ID
dgv8291n71	CNV	Loss	21882294
dgv8290n71	CNV	Loss	21882294
nsv893865	CNV	Loss	21882294
dgv8287n71	CNV	Loss	21882294
dgv8293n71	CNV	Loss	21882294
nsv893874	CNV	Loss	21882294
dgv497n21	CNV	Loss	19592680
nsv893859	CNV	Loss	21882294
nsv893860	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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OMIM gene information: 610135 OMIM disorders: --

Find genes that share disorders with ST6GALNAC6 About GenesLikeMe

Export disorders for ST6GALNAC6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ST6GALNAC6 gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with ST6GALNAC6)

Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides. (PubMed id 12668675)^{1, 2, 3} Tsuchida A.... Furukawa K. (J. Biol. Chem. 2003)
Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers. (PubMed id 17123352)^{1, 2} Senda M.... Furukawa K. (Biochem. J. 2007)
The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. (PubMed id 15843597)^{1, 2} Harduin-Lepers A.... Oriol R. (Glycobiology 2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (Genome Res. 2003)
Carbohydrate antigen sialyl Lewis a - its pathophysiological significance and induction mechanism in cancer progression. (PubMed id 17760270)² Kannagi R. (Chang Gung Med. J. 2007)
Identification of linkage-specific sequence motifs in sialyltransferases. (PubMed id 16207893)² Patel R.Y. and Balaji P.V. (Glycobiology 2006)
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)¹ Lim J.... Zoghbi H.Y. (Cell 2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S.... Malek J. (Genome Res. 2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)² Humphray S.J.... Dunham I. (Nature 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 30815	HGNC: 23364	AceView: AK1andSIAT7F	Ensembl:ENSG00000160408	euGenes: HUgn30815
ECgene: ST6GALNAC6	Kegg: 30815	H-InvDB: ST6GALNAC6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ST6GALNAC6	Pharmacogenomics, SNPs, Pathways
GGDB	http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST6GALNAC6
Functional Glycomics Gateway - GTase	http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_635

Intellectual Property for ST6GALNAC6 gene
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Patent Information for ST6GALNAC6 gene:
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GeneCards and IP:
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ST6GALNAC6 Gene

ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide...

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ST6GALNAC6 Gene

ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide...

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