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ST6GALNAC5 Gene

protein-coding   GIFtS: 55
GCID: GC01P077333

ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide...

(Previous name: sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl...)
(Previous symbol: SIAT7E)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ST6
(Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide
Alpha-2,6-Sialyltransferase 51 2
     Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 52
SIAT7E1 2 3 5     Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase V2
Sialyltransferase 7
((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl
Galactosaminide Alpha-2,6-Sialyltransferase) E1 2
     Alpha-N-Acetylneuraminyl 2,3-Betagalactosyl-1,3)-N-Acetyl Galactosaminide
Alpha-2,6-Sialyltransferase E2
Sialyltransferase 7E2 3     Sialyltransferase 7
(Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl
Galactosaminide Alpha-2,6-Sialyltransferase) E2
SIAT7-E2 3     ST6 Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide
Alpha-2,6-Sialyltransferase 52
ST6GalNAcV2 3     EC 2.4.99.-3
GalNAc Alpha-2,6-Sialyltransferase V2 3     EC 2.4.998
GD1 Alpha Synthase2 3     EC 2.4.99.78
ST6GalNAc V2 3     

External Ids:    HGNC: 193421   Entrez Gene: 818492   Ensembl: ENSG000001170697   OMIM: 6101345   UniProtKB: Q9BVH73   

Export aliases for ST6GALNAC5 gene to outside databases

Previous GC identifers: GC01P077046 GC01P075464


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ST6GALNAC5 Gene:
ST6GALNAC5 belongs to a family of sialyltransferases that modify proteins and ceramides on the cell surface to
alter cell-cell or cell-extracellular matrix interactions (Tsuchida et al., 2003 (PubMed 12668675)).(supplied by
OMIM, Mar 2008)

GeneCards Summary for ST6GALNAC5 Gene:
ST6GALNAC5 (ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5) is a protein-coding gene. Diseases associated with ST6GALNAC5 include influenza, and cerebritis. GO annotations related to this gene include alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity and sialyltransferase activity. An important paralog of this gene is ST6GALNAC3.

UniProtKB/Swiss-Prot: SIA7E_HUMAN, Q9BVH7
Function: Involved in the biosynthesis of ganglioside GD1a from GM1b. It exhibits higher activity with glycolipids
than with glycoproteins (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ST6GALNAC5 gene promoter:
         GR   AML1a   Tal-1   GR-beta   MyoD   AP-4   E47   Max   GR-alpha   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidST6GALNAC5 promoter sequence
   Search Chromatin IP Primers for ST6GALNAC5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST6GALNAC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

ST6GALNAC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST6GALNAC5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P077333:  view genomic region     (about GC identifiers)

Start:
77,333,126 bp from pter      End:
77,531,396 bp from pter
Size:
198,271 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIA7E_HUMAN, Q9BVH7 (See protein sequence)
Recommended Name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5  
Size: 336 amino acids; 38443 Da
Secondary accessions: B1AK82

Explore the universe of human proteins at neXtProt for ST6GALNAC5: NX_Q9BVH7

Explore proteomics data for ST6GALNAC5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn137, Asn161
  • Selected DME Specific Peptides for ST6GALNAC5 (Q9BVH7) (see all 5)
     HRFITEK  LSTGWFT  TVFIFWGP  IRMNDAPT 


    See ST6GALNAC5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_112227.1  
    ENSEMBL proteins: 
     ENSP00000417583   ENSP00000436263  
    Reactome Protein details: Q9BVH7

    ST6GALNAC5 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
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    Browse Proteins at Cloud-Clone Corp.

    ST6GALNAC5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ST3G: Sialyltransferases

    2 InterPro protein domains:
     IPR001675 Glyco_trans_29
     IPR012163 Sialyl_trans

    Graphical View of Domain Structure for InterPro Entry Q9BVH7

    ProtoNet protein and cluster: Q9BVH7

    1 Blocks protein domain: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIA7E_HUMAN, Q9BVH7
    Similarity: Belongs to the glycosyltransferase 29 family


    ST6GALNAC5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIA7E_HUMAN, Q9BVH7
    Function: Involved in the biosynthesis of ganglioside GD1a from GM1b. It exhibits higher activity with glycolipids
    than with glycoproteins (By similarity)

         Enzyme Numbers (IUBMB): EC 2.4.99.-1 EC 2.4.992 EC 2.4.99.72

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001665alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity ISS--
    GO:0008373sialyltransferase activity ISS12668675
         
    ST6GALNAC5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ST6GALNAC5:
     Increased cell number in G1, a  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ST6GALNAC5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ST6GALNAC5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ST6GALNAC5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ST6GALNAC5

    miRNA
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    miRTarBase miRNAs that target ST6GALNAC5:
    hsa-mir-148b-3p (MIRT019483)

    Block miRNA regulation of human, mouse, rat ST6GALNAC5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ST6GALNAC5 (see all 10):
    hsa-miR-3671 hsa-miR-892b hsa-miR-193a-3p hsa-miR-548am hsa-miR-429 hsa-miR-200c hsa-miR-377 hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidST6GALNAC5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ST6GALNAC5

    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST6GALNAC5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIA7E_HUMAN, Q9BVH7: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular2
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus ----
    GO:0016021integral component of membrane ----
    GO:0030173integral component of Golgi membrane IEA--

    ST6GALNAC5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ST6GALNAC5 About    
    See pathways by source

    SuperPathContained pathways About
    1Glycosphingolipid biosynthesis - ganglio series
    Glycosphingolipid biosynthesis - ganglio series0.53
    2Metabolism
    Metabolic pathways0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for ST6GALNAC5
        Sialic acid metabolism


    2 Kegg Pathways  (Kegg details for ST6GALNAC5):
        Glycosphingolipid biosynthesis - ganglio series
    Metabolic pathways

    UniProtKB/Swiss-Prot: SIA7E_HUMAN, Q9BVH7
    Pathway: Protein modification; protein glycosylation


    ST6GALNAC5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ST6GALNAC5
    Interactions:

        Search GeneGlobe Interaction Network for ST6GALNAC5

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for ST6GALNAC5 (Q9BVH73 ENSP000004175834) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    WDR6Q9NNW53I2D: score=1 
    ST3GAL1ENSP000003184454STRING: ENSP00000318445
    ST8SIA5ENSP000003213434STRING: ENSP00000321343
    ST3GAL2ENSP000003454774STRING: ENSP00000345477
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation IEA--
    GO:0006688glycosphingolipid biosynthetic process ISS--
    GO:0009312oligosaccharide biosynthetic process ISS12668675
    GO:0097503sialylation ISS--

    ST6GALNAC5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ST6GALNAC5 (SIA7E)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ST6GALNAC5 gene: 
    NM_030965.1  

    Unigene Cluster for ST6GALNAC5:

    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
    Hs.303609  [show with all ESTs]
    Unigene Representative Sequence: AK056241
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477717(uc001dhi.3 uc010ori.2) ENST00000480428 ENST00000318803(uc009wbw.3)
    ENST00000496845 ENST00000488940
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ST6GALNAC5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ST6GALNAC5 (see all 10):
    hsa-miR-3671 hsa-miR-892b hsa-miR-193a-3p hsa-miR-548am hsa-miR-429 hsa-miR-200c hsa-miR-377 hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidST6GALNAC5 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: ST6GALNAC5 (NM_030965)
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      QuantiTect SYBR Green Assays in human, mouse, rat ST6GALNAC5
      QuantiFast Probe-based Assays in human, mouse, rat ST6GALNAC5

    Additional mRNA sequence: 

    AF131837.1 AJ507292.1 AK056241.1 AK095758.1 AK295019.1 AK300902.1 BC001201.1 BC025749.1 

    7 DOTS entries:

    DT.456106  DT.100015551  DT.121330717  DT.40215905  DT.432898  DT.91955288  DT.92011082 

    Selected AceView cDNA sequences (see all 49):

    AK056241 BI916580 AI024886 Z44914 F08298 Z38900 AI401684 NM_030965 
    Z39792 AJ507292 CR610298 AW161096 BC001201 BE251546 AW613475 AA081615 
    AA709472 AA084505 BX431327 CB152980 AK095758 Z43731 BG474817 Z41766 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ST6GALNAC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGTCGTCT
    ST6GALNAC5 Expression
    About this image


    ST6GALNAC5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
    ST6GALNAC5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ST6GALNAC5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.303609
        Custom PCR Arrays for ST6GALNAC5
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ST6GALNAC5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St6galnac51 , 5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more1, 5 89.15(n)1
    91.04(a)1
      3 (77.16 cM)5
    269381  NM_012028.41  NP_036158.31 
     1528170815 
    chicken
    (Gallus gallus)
    Aves ST6GALNAC51 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more 77.51(n)
    79.64(a)
      407778  NM_001277494.1  NP_001264423.1 
    lizard
    (Anolis carolinensis)
    Reptilia ST6GALNAC56
    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl...
    74(a)
    1 ↔ 1
    GL343194.1(4058332-4174907)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia st6galnac51 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more 73.38(n)
    76.04(a)
      407766  NM_001172277.1  NP_001165748.1 
    zebrafish
    (Danio rerio)
    Actinopterygii st6galnac5a1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more 70.11(n)
    72.26(a)
      563594  XM_686955.5  XP_692047.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta ST6Gal6
    Sialyltransferase
    13(a)
    1 → many
    2R(20578945-20581909)


    ENSEMBL Gene Tree for ST6GALNAC5 (if available)
    TreeFam Gene Tree for ST6GALNAC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ST6GALNAC5 gene
    ST6GALNAC32  ST6GAL22  ST6GAL12  ST6GALNAC42  ST6GALNAC62  
    3 SIMAP similar genes for ST6GALNAC5 using alignment to 3 protein entries:     SIA7E_HUMAN (see all proteins):
    ST6GALNAC6    ST6GALNAC4    ST6GALNAC3

    ST6GALNAC5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ST6GALNAC5 (see all 3910)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1422523141,2
    --77331247(+) GTTTTC/GTTTAT 1 -- us2k10--------
    rs14032431,2
    C,F,O,H--77331308(-) CAGCCA/GTTTCA 1 -- us2k124Minor allele frequency- G:0.10NS EA NA WA CSA 2137
    rs1479577881,2
    C--77331451(+) GGAAAA/GAAAAA 1 -- us2k10--------
    rs1882679671,2
    --77331506(+) GTCCAA/GCATGC 1 -- us2k10--------
    rs1401618081,2
    C--77331619(+) ATAATA/CCTGAA 1 -- us2k10--------
    rs740897951,2
    C,F--77331646(+) TCTAAG/TAGCAT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1929466801,2
    --77331659(+) AAAAGA/GATCCC 1 -- us2k10--------
    rs1839218871,2
    --77331726(+) TTAATC/TTGAGT 1 -- us2k10--------
    rs1477138291,2
    --77331750(+) ATACAA/GTAAAG 1 -- us2k10--------
    rs1167050271,2
    F--77331851(+) AAATAG/CTTTCA 1 -- us2k11Minor allele frequency- C:0.02NA 120

    HapMap Linkage Disequilibrium report for ST6GALNAC5 (77333126 - 77531396 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ST6GALNAC5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2750141CNV Deletion23290073
    esv2667776CNV Deletion23128226
    esv2663416CNV Deletion23128226
    esv2676599CNV Deletion23128226
    nsv1510CNV Insertion18451855
    nsv871501CNV Loss21882294
    nsv830292CNV Loss17160897
    nsv820187CNV Gain19587683
    esv259552OTHER Complex20981092
    esv259864OTHER Complex20981092

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610134    OMIM disorders: --

    2 diseases for ST6GALNAC5:    
    About MalaCards
    influenza    cerebritis


    ST6GALNAC5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ST6GALNAC5
    Human Genome Epidemiology (HuGE) Navigator: ST6GALNAC5 (1 document)

    Export disorders for ST6GALNAC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ST6GALNAC5 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with ST6GALNAC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Molecular cloning of brain-specific GD1alpha synthase (ST6GalNAc V) containing CAG/Glutamine repeats. (PubMed id 10521438)1, 3 Okajima T....Furukawa K. (J. Biol. Chem. 1999)
    5. A novel glycosyltransferase with a polyglutamine repeat; a new candidate for GD1alpha synthase (ST6GalNAc V)(1). (PubMed id 10601645)1, 3 Ikehara Y....Tatematsu M. (FEBS Lett. 1999)
    6. Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides. (PubMed id 12668675)1, 9 Tsuchida A.... Furukawa K. (J. Biol. Chem. 2003)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. (PubMed id 15843597)1 Harduin-Lepers A.... Oriol R. (Glycobiology 2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (Genome Res. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81849 HGNC: 19342 AceView: SIAT7E Ensembl:ENSG00000117069 euGenes: HUgn81849
    ECgene: ST6GALNAC5 Kegg: 81849 H-InvDB: ST6GALNAC5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ST6GALNAC5 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST6GALNAC5
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_634

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ST6GALNAC5 gene:
    Search GeneIP for patents involving ST6GALNAC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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