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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ST6GALNAC5 Gene

protein-coding   GIFtS: 54
GCID: GC01P077333

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide...

(Previous name: sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl...)
(Previous symbol: SIAT7E)
 Explore 2 diseases affiliated with
ST6GALNAC5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ST6GALNAC5    

Aliases
for ST6GALNAC5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ST6
(Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide
Alpha-2,6-Sialyltransferase 51 2
     MGC31841
SIAT7E1 2 3 5     Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 52
ST6GalNAcV1 2 3     Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase V2
Sialyltransferase 7
((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide
Alpha-2,6-Sialyltransferase) E1 2
     Alpha-N-Acetylneuraminyl 2,3-Betagalactosyl-1,3)-N-Acetyl Galactosaminide
Alpha-2,6-Sialyltransferase E2
Sialyltransferase 7E2 3     Sialyltransferase 7 (Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl
Galactosaminide Alpha-2,6-Sialyltransferase) E2
SIAT7-E2 3     ST6 Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide
Alpha-2,6-Sialyltransferase 52
GalNAc Alpha-2,6-Sialyltransferase V2 3     EC 2.4.99.-3
GD1 Alpha Synthase2 3     EC 2.4.998
ST6GalNAc V2 3     EC 2.4.99.78

External Ids:    HGNC: 193421   Entrez Gene: 818492   Ensembl: ENSG000001170697   OMIM: 6101345   UniProtKB: Q9BVH73   

Export aliases for ST6GALNAC5 gene to outside databases

Previous GC identifers: GC01P077046 GC01P075464


Summaries
for ST6GALNAC5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ST6GALNAC5:
ST6GALNAC5 belongs to a family of sialyltransferases that modify proteins and ceramides on the cell surface to alter
cell-cell or cell-extracellular matrix interactions (Tsuchida et al., 2003 (PubMed 12668675)).(supplied by OMIM, Mar
2008)

UniProtKB/Swiss-Prot: SIA7E_HUMAN, Q9BVH7
Function: Involved in the biosynthesis of ganglioside GD1a from GM1b. It exhibits higher activity with glycolipids than
with glycoproteins (By similarity)




Genomic Views
for ST6GALNAC5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ST6GALNAC5 gene promoter:
         GR   AML1a   Tal-1   GR-beta   MyoD   AP-4   E47   Max   GR-alpha   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ST6GALNAC5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ST6GALNAC5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST6GALNAC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

ST6GALNAC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST6GALNAC5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P077333:  view genomic region     (about GC identifiers)

Start:
 77,333,126 bp from pter      End:
 77,531,396 bp from pter
Size:
 198,271 bases      Orientation:
 plus strand

Proteins
for ST6GALNAC5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SIA7E_HUMAN, Q9BVH7 (See protein sequence)
Recommended Name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5  
Size: 336 amino acids; 38443 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Secondary accessions: B1AK82

Explore the universe of human proteins at neXtProt for ST6GALNAC5: NX_Q9BVH7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BVH7

    • 4/5 DME Specific Peptides for ST6GALNAC5 (Q9BVH7) (see all 5)
     HRFITEK  LSTGWFT  TVFIFWGP  IRMNDAPT 

    ST6GALNAC5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_112227.1  
    ENSEMBL proteins: 
     ENSP00000417583   ENSP00000436263  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ST6GALNAC5 (ST6 GalNAc alpha-2,6-sialyltransferaseV/ST6GALNAC5)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: ST6GALNAC5
    OriGene Custom Protein Services for ST6GALNAC5 
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    Novus Biologicals ST6GALNAC5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ST6GALNAC5

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030173integral to Golgi membrane IEA--


    ST6GALNAC5 for ontologies           About GeneDecksing



    ST6GALNAC5 Antibody Products: 
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    Assay Products for ST6GALNAC5: 
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    Uscn ELISAs and CLIAs for ST6GALNAC5

    Protein Domains /
    Families
    for ST6GALNAC5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ST6GALNAC5 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001675 Glyco_trans_29
     IPR012163 Sialyl_trans

    Graphical View of Domain Structure for InterPro Entry Q9BVH7

    ProtoNet protein and cluster: Q9BVH7

    1 Blocks protein family: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIA7E_HUMAN, Q9BVH7
    Similarity: Belongs to the glycosyltransferase 29 family


    Function
    for ST6GALNAC5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SIA7E_HUMAN, Q9BVH7
    Function: Involved in the biosynthesis of ganglioside GD1a from GM1b. It exhibits higher activity with glycolipids than
    with glycoproteins (By similarity)

    Enzyme Numbers (IUBMB): EC 2.4.99.-1 EC 2.4.992 EC 2.4.99.72

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ST6GALNAC5
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST6GALNAC5
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ST6GALNAC5 (see all 10):
    hsa-miR-3671 hsa-miR-892b hsa-miR-193a-3p hsa-miR-548am hsa-miR-429 hsa-miR-200c hsa-miR-377 hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmid: ST6GALNAC5 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ST6GALNAC5 (see all 4)
    OriGene shRNA RFP: ST6GALNAC5
    OriGene siRNA: ST6GALNAC5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST6GALNAC5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ST6GALNAC5

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ST6GALNAC5 (see all 2)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ST6GALNAC5 (NM_030965)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST6GALNAC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST6GALNAC5 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ST6GALNAC5
    Search LifeMap BioReagents cell lines for ST6GALNAC5

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST6GALNAC5

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001665alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity ISS--
    GO:0008373sialyltransferase activity ISS12668675


    ST6GALNAC5 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ST6GALNAC5:
     Increased cell number in G1, a  Synthetic lethal with Ras 


    Pathways & Interactions
    for ST6GALNAC5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ganglio Sphingolipid Metabolism
    		Glycosphingolipid biosynthesis - ganglio series0.53
    2Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for ST6GALNAC5):
        Glycosphingolipid biosynthesis - ganglio series
    Metabolic pathways

    UniProtKB/Swiss-Prot: SIA7E_HUMAN, Q9BVH7
    Pathway: Protein modification; protein glycosylation


    ST6GALNAC5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ST6GALNAC5

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for ST6GALNAC5 (Q9BVH73 ENSP000004175834) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    WDR6Q9NNW53I2D: score=1 
    ST3GAL1ENSP000003184454STRING: ENSP00000318445
    ST3GAL2ENSP000003454774STRING: ENSP00000345477
    ST8SIA5ENSP000003213434STRING: ENSP00000321343
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation IEA--
    GO:0006688glycosphingolipid biosynthetic process ISS--
    GO:0009312oligosaccharide biosynthetic process ISS12668675


    ST6GALNAC5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ST6GALNAC5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ST6GALNAC5
    Search CenterWatch for drugs/clinical trials and news about ST6GALNAC5 / SIA7E 

    Transcripts
    for ST6GALNAC5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ST6GALNAC5 gene: 
    NM_030965.1  

    Unigene Cluster for ST6GALNAC5:

    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
    Hs.303609  [show with all ESTs]
    Unigene Representative Sequence: AK056241
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477717(uc001dhi.3 uc010ori.2) ENST00000318803(uc009wbw.3)
    ENST00000480428 ENST00000496845 ENST00000488940

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ST6GALNAC5
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST6GALNAC5
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ST6GALNAC5 (see all 10):
    hsa-miR-3671 hsa-miR-892b hsa-miR-193a-3p hsa-miR-548am hsa-miR-429 hsa-miR-200c hsa-miR-377 hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmid: ST6GALNAC5 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ST6GALNAC5 (see all 4)
    OriGene shRNA RFP: ST6GALNAC5
    OriGene siRNA: ST6GALNAC5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST6GALNAC5
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ST6GALNAC5 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ST6GALNAC5
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ST6GALNAC5 (NM_030965)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST6GALNAC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST6GALNAC5 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ST6GALNAC5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ST6GALNAC5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ST6GALNAC5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST6GALNAC5

    Additional cDNA sequence: 

    AF131837.1 AJ507292.1 AK056241.1 AK095758.1 AK295019.1 AK300902.1 BC001201.1 BC025749.1 

    7 DOTS entries:

    DT.456106  DT.100015551  DT.121330717  DT.40215905  DT.432898  DT.91955288  DT.92011082 

    24/49 AceView cDNA sequences (see all 49):

    BI916580 Z44914 Z38900 F08298 AI401684 AJ507292 AK056241 Z39792 
    NM_030965 BE251546 BC001201 AW161096 AI024886 CR610298 AW613475 AF131837 
    F08726 CB152980 AK095758 AA670246 BX431327 AA081615 AA709472 AL561723 

    GeneLoc Exon Structure


    Expression
    for ST6GALNAC5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ST6GALNAC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTGTCGTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ST6GALNAC5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)

    See ST6GALNAC5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ST6GALNAC5

    SOURCE GeneReport for Unigene cluster: Hs.303609
        SABiosciences Custom PCR Arrays for ST6GALNAC5
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST6GALNAC5

    Orthologs
    for ST6GALNAC5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ST6GALNAC5 gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ST6GALNAC51 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more 77.71(n)
    79.64(a)    		   407778  XM_422393.3  XP_422393.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ST6GALNAC56
    		 --
    		 84(a)
    		 1 ↔ 1
    		 GL343194.1(4156453-4174907)
    zebrafish
    (Danio rerio)    		 Actinopterygii st6galnac5a1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more 69.89(n)
    70.32(a)    		   563594  XM_686955.4  XP_692047.4 


    ENSEMBL Gene Tree for ST6GALNAC5 (if available)
    TreeFam Gene Tree for ST6GALNAC5 (if available) 

    Paralogs
    for ST6GALNAC5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ST6GALNAC5 gene
    ST6GALNAC32  ST6GAL22  ST6GAL12  ST6GALNAC42  ST6GALNAC62  
    3 SIMAP similar genes for ST6GALNAC5 using alignment to 2 protein entries:     SIA7E_HUMAN (see all proteins):
    ST6GALNAC6    ST6GALNAC4    ST6GALNAC3

    ST6GALNAC5 for paralogs           About GeneDecksing



    Genomic Variants
    for ST6GALNAC5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3393 NCBI SNPs in ST6GALNAC5 are shown (see all 3393)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1422523141,2
    		--77331247(+) GTTTTC/GTTTAT 1 -- us2k10--------
    rs14032431,2
    		C,F,O,H,--77331308(-) CAGCCA/GTTTCA 1 -- us2k124Minor allele frequency- G:0.10NS EA NA WA CSA 2137
    rs1479577881,2
    		--77331451(+) GGAAAA/GAAAAA 1 -- us2k10--------
    rs1882679671,2
    		--77331506(+) GTCCAA/GCATGC 1 -- us2k10--------
    rs1401618081,2
    		--77331619(+) ATAATA/CCTGAA 1 -- us2k10--------
    rs740897951,2
    		C,--77331646(+) TCTAAG/TAGCAT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1929466801,2
    		--77331659(+) AAAAGA/GATCCC 1 -- us2k10--------
    rs1839218871,2
    		--77331726(+) TTAATC/TTGAGT 1 -- us2k10--------
    rs1477138291,2
    		--77331750(+) ATACAA/GTAAAG 1 -- us2k10--------
    rs1167050271,2
    		F,--77331851(+) AAATAG/CTTTCA 1 -- us2k11Minor allele frequency- C:0.02NA 120

    HapMap Linkage Disequilibrium report for ST6GALNAC5 (77333126 - 77531396 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for ST6GALNAC5
         4 CNVs: 74538 84310 58407 84311

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    Disorders / Diseases
    for ST6GALNAC5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ST6GALNAC5 for disorders           About GeneDecksing

    OMIM gene information: 610134    OMIM disorders: --

    2 diseases for ST6GALNAC5:    About MalaCards
    colon cancer    influenza

    Human Genome Epidemiology (HuGE) Navigator: ST6GALNAC5 (1 document)

    Export disorders for ST6GALNAC5 gene to outside databases

    Publications
    for ST6GALNAC5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ST6GALNAC5 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with ST6GALNAC5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. A novel glycosyltransferase with a polyglutamine repeat; a new candidate for GD1alpha synthase (ST6GalNAc V)(1). (PubMed id 10601645)1, 3 Ikehara Y....Tatematsu M. (1999)
    4. Molecular cloning of brain-specific GD1alpha synthase (ST6GalNAc V) containing CAG/Glutamine repeats. (PubMed id 10521438)1, 3 Okajima T....Furukawa K. (1999)
    5. Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides. (PubMed id 12668675)1, 9 Tsuchida A.... Furukawa K. (2003)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    8. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. (PubMed id 15843597)1 Harduin-Lepers A.... Oriol R. (2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    External Searches for ST6GALNAC5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing ST6GALNAC5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81849 HGNC: 19342 AceView: SIAT7E Ensembl:ENSG00000117069 euGenes: HUgn81849
    ECgene: ST6GALNAC5 Kegg: 81849 H-InvDB: ST6GALNAC5

    Other Databases showing ST6GALNAC5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ST6GALNAC5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ST6GALNAC5 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST6GALNAC5
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_634

    Intellectual Property
    for ST6GALNAC5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ST6GALNAC5 gene:
    Search GeneIP for patents involving ST6GALNAC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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