Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ST6GALNAC5 Gene

Aliases for ST6GALNAC5 Gene

  • ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 5 2
  • ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 5 2 3 5
  • Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) E 2 3
  • ST6 GalNAc Alpha-2,6-Sialyltransferase 5 2 3
  • GalNAc Alpha-2,6-Sialyltransferase V 3 4
  • Sialyltransferase 7E 3 4
  • GD1 Alpha Synthase 3 4
  • ST6GalNAc V 3 4
  • ST6GalNAcV 3 4
  • SIAT7-E 3 4
  • SIAT7E 3 4
  • Alpha-N-Acetylneuraminyl 2,3-Betagalactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase E 3
  • ST6 Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 5 3
  • Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase V 3
  • EC 63
  • EC 2.4.99.- 4
  • EC 2.4.99 63

External Ids for ST6GALNAC5 Gene

Previous HGNC Symbols for ST6GALNAC5 Gene

  • SIAT7E

Previous GeneCards Identifiers for ST6GALNAC5 Gene

  • GC01P077046
  • GC01P077333
  • GC01P075464

Summaries for ST6GALNAC5 Gene

Entrez Gene Summary for ST6GALNAC5 Gene

  • The protein encoded by this gene is a Golgi type II transmembrane glycosyltransferase. The encoded protein catalyzes the transfer of sialic acid to cell surface proteins to modulate cell-cell interactions. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for ST6GALNAC5 Gene

ST6GALNAC5 (ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 5) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Synthesis of substrates in N-glycan biosythesis. GO annotations related to this gene include sialyltransferase activity and alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. An important paralog of this gene is ST6GALNAC4.

UniProtKB/Swiss-Prot for ST6GALNAC5 Gene

  • Involved in the biosynthesis of ganglioside GD1a from GM1b. It exhibits higher activity with glycolipids than with glycoproteins (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST6GALNAC5 Gene

Genomics for ST6GALNAC5 Gene

Regulatory Elements for ST6GALNAC5 Gene

Enhancers for ST6GALNAC5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ST6GALNAC5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ST6GALNAC5 Gene

76,867,441 bp from pter
77,069,167 bp from pter
201,727 bases
Plus strand

Genomic View for ST6GALNAC5 Gene

Genes around ST6GALNAC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST6GALNAC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST6GALNAC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST6GALNAC5 Gene

Proteins for ST6GALNAC5 Gene

  • Protein details for ST6GALNAC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
    Protein Accession:
    Secondary Accessions:
    • B1AK82

    Protein attributes for ST6GALNAC5 Gene

    336 amino acids
    Molecular mass:
    38443 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST6GALNAC5 Gene

Proteomics data for ST6GALNAC5 Gene at MOPED

Selected DME Specific Peptides for ST6GALNAC5 Gene

Post-translational modifications for ST6GALNAC5 Gene

  • Glycosylation at Asn 137 and Asn 161
  • Modification sites at PhosphoSitePlus

Other Protein References for ST6GALNAC5 Gene

Domains & Families for ST6GALNAC5 Gene

Gene Families for ST6GALNAC5 Gene

Protein Domains for ST6GALNAC5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 29 family.
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST6GALNAC5: view

Function for ST6GALNAC5 Gene

Molecular function for ST6GALNAC5 Gene

UniProtKB/Swiss-Prot Function:
Involved in the biosynthesis of ganglioside GD1a from GM1b. It exhibits higher activity with glycolipids than with glycoproteins (By similarity).

Enzyme Numbers (IUBMB) for ST6GALNAC5 Gene

Gene Ontology (GO) - Molecular Function for ST6GALNAC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity ISS,TAS --
genes like me logo Genes that share ontologies with ST6GALNAC5: view
genes like me logo Genes that share phenotypes with ST6GALNAC5: view

Animal Model Products

miRNA for ST6GALNAC5 Gene

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ST6GALNAC5 Gene

Localization for ST6GALNAC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST6GALNAC5 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for ST6GALNAC5 Gene COMPARTMENTS Subcellular localization image for ST6GALNAC5 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ST6GALNAC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
genes like me logo Genes that share ontologies with ST6GALNAC5: view

Pathways & Interactions for ST6GALNAC5 Gene

genes like me logo Genes that share pathways with ST6GALNAC5: view

UniProtKB/Swiss-Prot Q9BVH7-SIA7E_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for ST6GALNAC5 Gene

Gene Ontology (GO) - Biological Process for ST6GALNAC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001574 ganglioside biosynthetic process IBA --
GO:0006486 protein glycosylation IEA --
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0009312 oligosaccharide biosynthetic process ISS 12668675
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ST6GALNAC5: view

No data available for SIGNOR curated interactions for ST6GALNAC5 Gene

Drugs & Compounds for ST6GALNAC5 Gene

No Compound Related Data Available

Transcripts for ST6GALNAC5 Gene

Unigene Clusters for ST6GALNAC5 Gene

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC5 Gene

No ASD Table

Relevant External Links for ST6GALNAC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ST6GALNAC5 Gene

mRNA expression in normal human tissues for ST6GALNAC5 Gene

mRNA differential expression in normal tissues according to GTEx for ST6GALNAC5 Gene

This gene is overexpressed in Brain - Hippocampus (x6.1), Brain - Frontal Cortex (BA9) (x5.3), Brain - Anterior cingulate cortex (BA24) (x4.4), and Brain - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for ST6GALNAC5 Gene

This gene is overexpressed in Vitreous humor (68.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ST6GALNAC5 Gene

SOURCE GeneReport for Unigene cluster for ST6GALNAC5 Gene Hs.303609

genes like me logo Genes that share expression patterns with ST6GALNAC5: view

Protein tissue co-expression partners for ST6GALNAC5 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ST6GALNAC5 Gene

Orthologs for ST6GALNAC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST6GALNAC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ST6GALNAC5 35
  • 92.85 (n)
  • 93.35 (a)
  • 93 (a)
(Canis familiaris)
Mammalia ST6GALNAC5 35
  • 91.27 (n)
  • 92.26 (a)
  • 92 (a)
(Mus musculus)
Mammalia St6galnac5 35
  • 89.15 (n)
  • 91.04 (a)
St6galnac5 16
St6galnac5 36
  • 91 (a)
(Pan troglodytes)
Mammalia ST6GALNAC5 35
  • 99.6 (n)
  • 99.7 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia St6galnac5 35
  • 89.25 (n)
  • 91.04 (a)
(Monodelphis domestica)
Mammalia ST6GALNAC5 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia ST6GALNAC5 36
  • 82 (a)
(Gallus gallus)
Aves ST6GALNAC5 35
  • 77.51 (n)
  • 79.64 (a)
  • 73 (a)
(Anolis carolinensis)
Reptilia ST6GALNAC5 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia st6galnac5 35
  • 73.38 (n)
  • 76.04 (a)
(Danio rerio)
Actinopterygii st6galnac5a 35
  • 70.11 (n)
  • 72.26 (a)
st6galnac5a 36
  • 67 (a)
st6galnac5b 36
  • 63 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1875 35
fruit fly
(Drosophila melanogaster)
Insecta ST6Gal 36
  • 13 (a)
Species with no ortholog for ST6GALNAC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST6GALNAC5 Gene

Gene Tree for ST6GALNAC5 (if available)
Gene Tree for ST6GALNAC5 (if available)

Paralogs for ST6GALNAC5 Gene

Paralogs for ST6GALNAC5 Gene

(3) SIMAP similar genes for ST6GALNAC5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ST6GALNAC5: view

Variants for ST6GALNAC5 Gene

Sequence variations from dbSNP and Humsavar for ST6GALNAC5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs187956 -- 77,042,967(+) AAGGC(A/G)AGGGA intron-variant
rs199662 -- 77,066,868(+) TTTGG(C/T)GCTGT nc-transcript-variant, utr-variant-3-prime
rs199663 -- 77,066,917(+) CTGGG(A/G)AACAG nc-transcript-variant, utr-variant-3-prime
rs199664 -- 77,067,212(+) AAGGT(A/T)CTTTG nc-transcript-variant, utr-variant-3-prime
rs199665 -- 77,069,007(+) tgtct(C/T)tggag nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ST6GALNAC5 Gene

Variant ID Type Subtype PubMed ID
nsv1510 CNV Insertion 18451855
nsv820187 CNV Gain 19587683
esv2667776 CNV Deletion 23128226
nsv871501 CNV Loss 21882294
esv2676599 CNV Deletion 23128226
esv2750141 CNV Deletion 23290073
nsv830292 CNV Loss 17160897
esv2663416 CNV Deletion 23128226
esv259552 OTHER Complex 20981092
esv259864 OTHER Complex 20981092

Variation tolerance for ST6GALNAC5 Gene

Residual Variation Intolerance Score: 19.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.04; 68.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ST6GALNAC5 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST6GALNAC5 Gene

Disorders for ST6GALNAC5 Gene

Relevant External Links for ST6GALNAC5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ST6GALNAC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST6GALNAC5 Gene

Publications for ST6GALNAC5 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides. (PMID: 12668675) Tsuchida A. … Furukawa K. (J. Biol. Chem. 2003) 3 23
  3. Molecular cloning of brain-specific GD1alpha synthase (ST6GalNAc V) containing CAG/Glutamine repeats. (PMID: 10521438) Okajima T. … Furukawa K. (J. Biol. Chem. 1999) 2 3
  4. A novel glycosyltransferase with a polyglutamine repeat; a new candidate for GD1alpha synthase (ST6GalNAc V)(1). (PMID: 10601645) Ikehara Y. … Tatematsu M. (FEBS Lett. 1999) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ST6GALNAC5 Gene

Sources for ST6GALNAC5 Gene