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Aliases for ST6GALNAC4 Gene

Aliases for ST6GALNAC4 Gene

  • ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 4 2 3
  • SIAT7D 3 4 6
  • SIAT3C 3 4 6
  • Sialyltransferase 7D ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) 2 3
  • Sialyltransferase 3C 3 4
  • ST6GalNAc IV 3 4
  • ST6GALNACIV 3 4
  • EC 2.4.99.7 4 64
  • SIAT3-C 3 4
  • SIAT7-D 3 4
  • Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3-N-Acetyl-Galactosaminide Alpha-2,6-Sialyltransferase 3
  • ST6 Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminidealpha-2,6-Sialyltransferase 4 3
  • NeuAc-Alpha-2,3-Gal-Beta-1,3-GalNAc-Alpha-2, 6-Sialyltransferase Alpha2,6-Sialyltransferase 3
  • NeuAc-Alpha-2,3-Gal-Beta-1,3-GalNAc-Alpha-2,6-Sialyltransferase IV 3
  • NeuAc-Alpha-2,3-Gal-Beta-1,3-GalNAc-Alpha-2,6-Sialyltransferase 4
  • Sialyltransferase 7D 4
  • ST6GalNAc 3
  • EC 2.4.99 64
  • IV 3

External Ids for ST6GALNAC4 Gene

Previous Symbols for ST6GALNAC4 Gene

  • SIAT7D

Summaries for ST6GALNAC4 Gene

Entrez Gene Summary for ST6GALNAC4 Gene

  • The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST6GALNAC4 Gene

ST6GALNAC4 (ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 4) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include sialyltransferase activity and (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity. An important paralog of this gene is ST6GAL1.

UniProtKB/Swiss-Prot for ST6GALNAC4 Gene

  • Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. Prefers glycoproteins to glycolipids (By similarity).

Gene Wiki entry for ST6GALNAC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST6GALNAC4 Gene

Genomics for ST6GALNAC4 Gene

Genomic Location for ST6GALNAC4 Gene

Start:
127,907,886 bp from pter
End:
127,917,047 bp from pter
Size:
9,162 bases
Orientation:
Minus strand

Genomic View for ST6GALNAC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ST6GALNAC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST6GALNAC4 Gene

Regulatory Elements for ST6GALNAC4 Gene

Transcription factor binding sites by QIAGEN in the ST6GALNAC4 gene promoter:

Proteins for ST6GALNAC4 Gene

  • Protein details for ST6GALNAC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4F1-SIA7D_HUMAN
    Recommended name:
    Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase
    Protein Accession:
    Q9H4F1
    Secondary Accessions:
    • Q5T9D0
    • Q9NWU6
    • Q9UKU1
    • Q9ULB9
    • Q9Y3G3
    • Q9Y3G4

    Protein attributes for ST6GALNAC4 Gene

    Size:
    302 amino acids
    Molecular mass:
    34201 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST6GALNAC4 Gene

Proteomics data for ST6GALNAC4 Gene at MOPED

Selected DME Specific Peptides for ST6GALNAC4 Gene

Post-translational modifications for ST6GALNAC4 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn135

Other Protein References for ST6GALNAC4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ST6GALNAC4 Gene

Gene Families for ST6GALNAC4 Gene

HGNC:
  • ST3G :Sialyltransferases

Protein Domains for ST6GALNAC4 Gene

UniProtKB/Swiss-Prot:

SIA7D_HUMAN
Family:
  • Belongs to the glycosyltransferase 29 family.:
    • Q9H4F1
genes like me logo Genes that share domains with ST6GALNAC4: view

Function for ST6GALNAC4 Gene

Molecular function for ST6GALNAC4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: CMP-N-acetylneuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-(N-acetyl-alpha-neuraminyl-(2->6))-N-acetyl-D-galactosaminyl-R
UniProtKB/Swiss-Prot Function: Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. Prefers glycoproteins to glycolipids (By similarity).

Enzyme Numbers (IUBMB) for ST6GALNAC4 Gene

Gene Ontology (GO) - Molecular Function for ST6GALNAC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008373 sialyltransferase activity TAS 10207017
GO:0047290 (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity IEA --
genes like me logo Genes that share ontologies with ST6GALNAC4: view

Phenotypes for ST6GALNAC4 Gene

GenomeRNAi human phenotypes for ST6GALNAC4:
genes like me logo Genes that share phenotypes with ST6GALNAC4: view

miRNA for ST6GALNAC4 Gene

miRTarBase miRNAs that target ST6GALNAC4

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ST6GALNAC4 Gene

Localization for ST6GALNAC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST6GALNAC4 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST6GALNAC4 Gene COMPARTMENTS Subcellular localization image for ST6GALNAC4 gene
Compartment Confidence
golgi apparatus 5
nucleus 4
extracellular 3

Gene Ontology (GO) - Cellular Components for ST6GALNAC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST6GALNAC4: view

Pathways for ST6GALNAC4 Gene

genes like me logo Genes that share pathways with ST6GALNAC4: view

UniProtKB/Swiss-Prot Q9H4F1-SIA7D_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for ST6GALNAC4 Gene

Gene Ontology (GO) - Biological Process for ST6GALNAC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation --
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006493 protein O-linked glycosylation TAS --
GO:0006664 glycolipid metabolic process TAS 10207017
GO:0016266 O-glycan processing TAS --
genes like me logo Genes that share ontologies with ST6GALNAC4: view

Compounds for ST6GALNAC4 Gene

(2) HMDB Compounds for ST6GALNAC4 Gene

Compound Synonyms Cas Number PubMed IDs
Cytidine monophosphate
  • 5'-CMP
63-37-6
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-acetylneuraminate
22-12-8
genes like me logo Genes that share compounds with ST6GALNAC4: view

Transcripts for ST6GALNAC4 Gene

Unigene Clusters for ST6GALNAC4 Gene

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - -
SP2: - - - -
SP3: - -
SP4:
SP5:
SP6: - -

Relevant External Links for ST6GALNAC4 Gene

GeneLoc Exon Structure for
ST6GALNAC4
ECgene alternative splicing isoforms for
ST6GALNAC4

Expression for ST6GALNAC4 Gene

mRNA expression in normal human tissues for ST6GALNAC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ST6GALNAC4 Gene

SOURCE GeneReport for Unigene cluster for ST6GALNAC4 Gene Hs.3972

mRNA Expression by UniProt/SwissProt for ST6GALNAC4 Gene

Q9H4F1-SIA7D_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with ST6GALNAC4: view

Orthologs for ST6GALNAC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST6GALNAC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST6GALNAC4 36
  • 99.01 (n)
  • 98.01 (a)
ST6GALNAC4 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SIAT7B 37
  • 74 (a)
OneToOne
ST6GALNAC4 36
  • 88.19 (n)
  • 91.06 (a)
dog
(Canis familiaris)
Mammalia ST6GALNAC4 36
  • 90.84 (n)
  • 92.05 (a)
ST6GALNAC4 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St6galnac4 36
  • 85.98 (n)
  • 89.07 (a)
St6galnac4 16
St6galnac4 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ST6GALNAC4 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia St6galnac4 36
  • 85.87 (n)
  • 88.08 (a)
chicken
(Gallus gallus)
Aves ST6GALNAC4 36
  • 73.38 (n)
  • 68.9 (a)
ST6GALNAC4 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST6GALNAC4 37
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st6galnac4 36
  • 64.61 (n)
  • 64.36 (a)
zebrafish
(Danio rerio)
Actinopterygii st6galnac4 36
  • 61.59 (n)
  • 55.65 (a)
st6galnac4 37
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ST6Gal 37
  • 13 (a)
OneToMany
Species with no ortholog for ST6GALNAC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST6GALNAC4 Gene

ENSEMBL:
Gene Tree for ST6GALNAC4 (if available)
TreeFam:
Gene Tree for ST6GALNAC4 (if available)

Paralogs for ST6GALNAC4 Gene

Paralogs for ST6GALNAC4 Gene

Selected SIMAP similar genes for ST6GALNAC4 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ST6GALNAC4 Gene

genes like me logo Genes that share paralogs with ST6GALNAC4: view

Variants for ST6GALNAC4 Gene

Sequence variations from dbSNP and Humsavar for ST6GALNAC4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2182619 -- 127,918,787(+) TTGCT(A/G)GGGCC upstream-variant-2KB
rs2296703 -- 127,912,633(+) TGGCC(A/G/T)GAGCT synonymous-codon, reference, utr-variant-5-prime
rs3780668 -- 127,911,140(-) CTTCA(A/G)TCTCC intron-variant
rs4388550 -- 127,917,184(+) CGTGA(A/T)TGGCT upstream-variant-2KB
rs7026378 -- 127,909,827(+) GTGCT(A/G)TGGTC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ST6GALNAC4 Gene

Variant ID Type Subtype PubMed ID
nsv893859 CNV Loss 21882294
nsv893860 CNV Gain 21882294
nsv893865 CNV Loss 21882294
dgv8287n71 CNV Loss 21882294
dgv8290n71 CNV Loss 21882294
dgv8291n71 CNV Loss 21882294
dgv8293n71 CNV Loss 21882294
nsv466577 CNV Loss 19166990
esv2739055 CNV Deletion 23290073
nsv6722 CNV Insertion 18451855

Relevant External Links for ST6GALNAC4 Gene

HapMap Linkage Disequilibrium report
ST6GALNAC4

Disorders for ST6GALNAC4 Gene

No disorders were found for ST6GALNAC4 Gene.

No data available for UniProtKB/Swiss-Prot for ST6GALNAC4 Gene

Publications for ST6GALNAC4 Gene

  1. Cloning, expression and gene organization of a human Neu5Ac alpha 2- 3Gal beta 1-3GalNAc alpha 2,6-sialyltransferase: hST6GalNAcIV. (PMID: 11062056) Harduin-Lepers A. … Delannoy P. (Biochem. J. 2000) 2 3 4 23
  2. Molecular cloning and functional expression of two members of mouse NeuAcalpha2,3Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase family, ST6GalNAc III and IV. (PMID: 10207017) Lee Y.C. … Tsuji S. (J. Biol. Chem. 1999) 2 3
  3. Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. (PMID: 10369878) Gilley J. … Fried M. (Hum. Mol. Genet. 1999) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ST6GALNAC4 Gene

Sources for ST6GALNAC4 Gene

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