Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ST6GALNAC4 Gene

Aliases for ST6GALNAC4 Gene

  • ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 4 2 3 5
  • Sialyltransferase 7D ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) 2 3
  • ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 4 2 3
  • ST6 GalNAc Alpha-2,6-Sialyltransferase 4 2 3
  • Sialyltransferase 3C 3 4
  • ST6GalNAc IV 3 4
  • EC 4 61
  • SIAT3-C 3 4
  • SIAT7-D 3 4
  • SIAT7D 3 4
  • SIAT3C 3 4
  • Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3-N-Acetyl-Galactosaminide Alpha-2,6-Sialyltransferase 3
  • ST6 Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminidealpha-2,6-Sialyltransferase 4 3
  • NeuAc-Alpha-2,3-Gal-Beta-1,3-GalNAc-Alpha-2, 6-Sialyltransferase Alpha2,6-Sialyltransferase 3
  • NeuAc-Alpha-2,3-Gal-Beta-1,3-GalNAc-Alpha-2,6-Sialyltransferase IV 3
  • NeuAc-Alpha-2,3-Gal-Beta-1,3-GalNAc-Alpha-2,6-Sialyltransferase 4
  • Sialyltransferase 7D 4
  • ST6GalNAc 3
  • EC 2.4.99 61
  • IV 3

External Ids for ST6GALNAC4 Gene

Previous HGNC Symbols for ST6GALNAC4 Gene

  • SIAT7D

Previous GeneCards Identifiers for ST6GALNAC4 Gene

  • GC09M127751
  • GC09M129709
  • GC09M130671
  • GC09M100287

Summaries for ST6GALNAC4 Gene

Entrez Gene Summary for ST6GALNAC4 Gene

  • The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST6GALNAC4 Gene

ST6GALNAC4 (ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 4) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. GO annotations related to this gene include sialyltransferase activity and (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity. An important paralog of this gene is ST6GALNAC3.

UniProtKB/Swiss-Prot for ST6GALNAC4 Gene

  • Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. Prefers glycoproteins to glycolipids (By similarity).

Gene Wiki entry for ST6GALNAC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST6GALNAC4 Gene

Genomics for ST6GALNAC4 Gene

Regulatory Elements for ST6GALNAC4 Gene

Enhancers for ST6GALNAC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F127826 1.7 FANTOM5 Ensembl ENCODE 11.4 +88.8 88844 3.7 HDGF ATF1 ARID4B ZNF48 SLC30A9 ZNF121 REST KAT8 CREB3 NFIL3 FPGS CDK9 ENG FAM129B AK1 ST6GALNAC6 ST6GALNAC4 PIP5KL1 LOC105376284 TOR2A
GH09F127761 1.7 FANTOM5 Ensembl ENCODE 11.2 +150.2 150218 11.3 HDGF PKNOX1 ARNT MLX ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FPGS ENG SH2D3C LOC102723566 AK1 ST6GALNAC6 ST6GALNAC4 PIP5KL1 FAM129B SWI5
GH09F127824 1.2 Ensembl ENCODE 11.4 +91.6 91580 1.6 ELF3 HDAC1 ZFP64 ARID4B DMAP1 ZNF48 RAD21 RARA RCOR1 THAP11 ENG FPGS AK1 ST6GALNAC6 ST6GALNAC4 PIP5KL1 ENSG00000222421 LOC102723566
GH09F127869 1.1 Ensembl ENCODE 12.1 +47.0 47025 1.3 SREBF2 ARID4B RAD21 RARA RFX5 ZNF143 RCOR1 DEK MIXL1 THAP11 ST6GALNAC6 LOC102723566 FPGS ST6GALNAC4 PIP5KL1 PTRH1 TTC16 MIR4672 AK1
GH09F127582 1.2 Ensembl ENCODE 10.8 +332.1 332147 4.2 PKNOX1 ARID4B YBX1 ZNF2 BRCA1 GLIS2 ZNF207 ZNF143 DEK ZNF202 SNORA65 ZNF79 PTRH1 TTC16 CFAP157 ST6GALNAC4 PIP5KL1 URM1 ENG NAIF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ST6GALNAC4 on UCSC Golden Path with GeneCards custom track

Promoters for ST6GALNAC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Transcription factor binding sites by QIAGEN in the ST6GALNAC4 gene promoter:

Genomic Location for ST6GALNAC4 Gene

127,907,886 bp from pter
127,917,051 bp from pter
9,166 bases
Minus strand

Genomic View for ST6GALNAC4 Gene

Genes around ST6GALNAC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST6GALNAC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST6GALNAC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST6GALNAC4 Gene

Proteins for ST6GALNAC4 Gene

  • Protein details for ST6GALNAC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase
    Protein Accession:
    Secondary Accessions:
    • Q5T9D0
    • Q9NWU6
    • Q9UKU1
    • Q9ULB9
    • Q9Y3G3
    • Q9Y3G4

    Protein attributes for ST6GALNAC4 Gene

    302 amino acids
    Molecular mass:
    34201 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST6GALNAC4 Gene

Selected DME Specific Peptides for ST6GALNAC4 Gene


Post-translational modifications for ST6GALNAC4 Gene

  • Glycosylation at Asn 135
  • Modification sites at PhosphoSitePlus

Other Protein References for ST6GALNAC4 Gene

Domains & Families for ST6GALNAC4 Gene

Gene Families for ST6GALNAC4 Gene

Protein Domains for ST6GALNAC4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 29 family.
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST6GALNAC4: view

Function for ST6GALNAC4 Gene

Molecular function for ST6GALNAC4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
CMP-N-acetylneuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-(N-acetyl-alpha-neuraminyl-(2->6))-N-acetyl-D-galactosaminyl-R.
UniProtKB/Swiss-Prot Function:
Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. Prefers glycoproteins to glycolipids (By similarity).

Enzyme Numbers (IUBMB) for ST6GALNAC4 Gene

Gene Ontology (GO) - Molecular Function for ST6GALNAC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity TAS --
GO:0008373 sialyltransferase activity IEA,TAS 10207017
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0047290 (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity TAS --
genes like me logo Genes that share ontologies with ST6GALNAC4: view
genes like me logo Genes that share phenotypes with ST6GALNAC4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ST6GALNAC4

miRNA for ST6GALNAC4 Gene

miRTarBase miRNAs that target ST6GALNAC4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ST6GALNAC4 Gene

Localization for ST6GALNAC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST6GALNAC4 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST6GALNAC4 gene
Compartment Confidence
golgi apparatus 5
extracellular 3

Gene Ontology (GO) - Cellular Components for ST6GALNAC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST6GALNAC4: view

Pathways & Interactions for ST6GALNAC4 Gene

genes like me logo Genes that share pathways with ST6GALNAC4: view

UniProtKB/Swiss-Prot Q9H4F1-SIA7D_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for ST6GALNAC4 Gene

Gene Ontology (GO) - Biological Process for ST6GALNAC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001574 ganglioside biosynthetic process IBA --
GO:0006486 protein glycosylation IEA --
GO:0006664 glycolipid metabolic process TAS 10207017
GO:0009311 oligosaccharide metabolic process IBA --
GO:0016266 O-glycan processing TAS --
genes like me logo Genes that share ontologies with ST6GALNAC4: view

No data available for SIGNOR curated interactions for ST6GALNAC4 Gene

Drugs & Compounds for ST6GALNAC4 Gene

(2) Additional Compounds for ST6GALNAC4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytidine monophosphate
  • 5'-CMP
  • 5-Cytidylate
  • 5-Cytidylic acid
  • CMP
  • Cytidine 5'-monophosphate
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-Acetylneuraminate
  • CMP-N-Acylneuraminate
  • CMP-NeuNAc
  • Cytidine 5'-monophosphate N-acetylneuraminic acid
  • Cytidine Monophosphate N-Acetylneuraminate
genes like me logo Genes that share compounds with ST6GALNAC4: view

Transcripts for ST6GALNAC4 Gene

Unigene Clusters for ST6GALNAC4 Gene

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - -
SP2: - - - -
SP3: - -
SP6: - -

Relevant External Links for ST6GALNAC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ST6GALNAC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ST6GALNAC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ST6GALNAC4 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ST6GALNAC4 Gene

Protein tissue co-expression partners for ST6GALNAC4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ST6GALNAC4 Gene:


SOURCE GeneReport for Unigene cluster for ST6GALNAC4 Gene:


mRNA Expression by UniProt/SwissProt for ST6GALNAC4 Gene:

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with ST6GALNAC4: view

Primer Products

No data available for mRNA differential expression in normal tissues for ST6GALNAC4 Gene

Orthologs for ST6GALNAC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST6GALNAC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ST6GALNAC4 34 35
  • 99.01 (n)
(Canis familiaris)
Mammalia ST6GALNAC4 34 35
  • 90.84 (n)
(Bos Taurus)
Mammalia ST6GALNAC4 34
  • 88.19 (n)
  • 74 (a)
(Mus musculus)
Mammalia St6galnac4 34 16 35
  • 85.98 (n)
(Rattus norvegicus)
Mammalia St6galnac4 34
  • 85.87 (n)
(Ornithorhynchus anatinus)
Mammalia ST6GALNAC4 35
  • 73 (a)
(Gallus gallus)
Aves ST6GALNAC4 34 35
  • 73.38 (n)
(Anolis carolinensis)
Reptilia ST6GALNAC4 35
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia st6galnac4 34
  • 64.61 (n)
(Danio rerio)
Actinopterygii st6galnac4 34 35
  • 61.59 (n)
fruit fly
(Drosophila melanogaster)
Insecta ST6Gal 35
  • 13 (a)
Species where no ortholog for ST6GALNAC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST6GALNAC4 Gene

Gene Tree for ST6GALNAC4 (if available)
Gene Tree for ST6GALNAC4 (if available)

Paralogs for ST6GALNAC4 Gene

Paralogs for ST6GALNAC4 Gene

(3) SIMAP similar genes for ST6GALNAC4 Gene using alignment to 3 proteins: Pseudogenes for ST6GALNAC4 Gene

genes like me logo Genes that share paralogs with ST6GALNAC4: view

Variants for ST6GALNAC4 Gene

Sequence variations from dbSNP and Humsavar for ST6GALNAC4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1043012 -- 127,908,373(-) GCCAG(C/T)CGCCA upstream-variant-2KB, utr-variant-3-prime
rs1043018 -- 127,908,298(-) TATGG(A/T)TCCTG upstream-variant-2KB, utr-variant-3-prime
rs1043026 -- 127,908,031(-) GCCGC(C/T)CCTAC upstream-variant-2KB, utr-variant-3-prime
rs1062665 -- 127,908,033(-) CAGCC(A/G)CTCCT upstream-variant-2KB, utr-variant-3-prime
rs10739699 -- 127,908,898(+) GCAGG(C/G)ACCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST6GALNAC4 Gene

Variant ID Type Subtype PubMed ID
nsv6722 CNV insertion 18451855
nsv615381 CNV loss 21841781
nsv466577 CNV loss 19166990
esv3621797 CNV gain 21293372
esv2739055 CNV deletion 23290073

Variation tolerance for ST6GALNAC4 Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ST6GALNAC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST6GALNAC4 Gene

Disorders for ST6GALNAC4 Gene

Relevant External Links for ST6GALNAC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ST6GALNAC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST6GALNAC4 Gene

Publications for ST6GALNAC4 Gene

  1. Cloning, expression and gene organization of a human Neu5Ac alpha 2- 3Gal beta 1-3GalNAc alpha 2,6-sialyltransferase: hST6GalNAcIV. (PMID: 11062056) Harduin-Lepers A. … Delannoy P. (Biochem. J. 2000) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Molecular cloning and functional expression of two members of mouse NeuAcalpha2,3Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase family, ST6GalNAc III and IV. (PMID: 10207017) Lee Y.C. … Tsuji S. (J. Biol. Chem. 1999) 2 3 64
  5. Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. (PMID: 10369878) Gilley J. … Fried M. (Hum. Mol. Genet. 1999) 3 4 64

Products for ST6GALNAC4 Gene

Sources for ST6GALNAC4 Gene

Loading form....