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Aliases for ST6GALNAC3 Gene

Aliases for ST6GALNAC3 Gene

  • ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 3 2
  • ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 3 2 3 5
  • Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) C 2 3
  • ST6 GalNAc Alpha-2,6-Sialyltransferase 3 2 3
  • GalNAc Alpha-2,6-Sialyltransferase III 3 4
  • Sialyltransferase 7C 3 4
  • ST6GALNAC III 2 3
  • ST6GALNACIII 3 4
  • SIAT7-C 3 4
  • SIAT7C 3 4
  • STY 3 4
  • ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltran 3
  • Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase III 3
  • ST6GalNAc III 4
  • EC 2.4.99.7 63
  • EC 2.4.99.- 4
  • PRO7177 3

External Ids for ST6GALNAC3 Gene

Previous HGNC Symbols for ST6GALNAC3 Gene

  • SIAT7C

Previous GeneCards Identifiers for ST6GALNAC3 Gene

  • GC01P076253
  • GC01P076540
  • GC01P074670

Summaries for ST6GALNAC3 Gene

Entrez Gene Summary for ST6GALNAC3 Gene

  • ST6GALNAC3 belongs to a family of sialyltransferases that transfer sialic acids from CMP-sialic acid to terminal positions of carbohydrate groups in glycoproteins and glycolipids (Lee et al., 1999 [PubMed 10207017]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ST6GALNAC3 Gene

ST6GALNAC3 (ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 3) is a Protein Coding gene. Among its related pathways are Glycosphingolipid biosynthesis - ganglio series and Metabolism. GO annotations related to this gene include sialyltransferase activity. An important paralog of this gene is ST6GALNAC4.

UniProtKB/Swiss-Prot for ST6GALNAC3 Gene

  • Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST6GALNAC3 Gene

Genomics for ST6GALNAC3 Gene

Regulatory Elements for ST6GALNAC3 Gene

Enhancers for ST6GALNAC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ST6GALNAC3 on UCSC Golden Path with GeneCards custom track

Promoters for ST6GALNAC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ST6GALNAC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ST6GALNAC3 Gene

Chromosome:
1
Start:
76,074,704 bp from pter
End:
76,634,601 bp from pter
Size:
559,898 bases
Orientation:
Plus strand

Genomic View for ST6GALNAC3 Gene

Genes around ST6GALNAC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST6GALNAC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST6GALNAC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST6GALNAC3 Gene

Proteins for ST6GALNAC3 Gene

  • Protein details for ST6GALNAC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDV1-SIA7C_HUMAN
    Recommended name:
    Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
    Protein Accession:
    Q8NDV1
    Secondary Accessions:
    • Q6PCE0
    • Q6UX29
    • Q8N259

    Protein attributes for ST6GALNAC3 Gene

    Size:
    305 amino acids
    Molecular mass:
    35395 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ST6GALNAC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ST6GALNAC3 Gene

Proteomics data for ST6GALNAC3 Gene at MOPED

Selected DME Specific Peptides for ST6GALNAC3 Gene

Post-translational modifications for ST6GALNAC3 Gene

  • Glycosylation at Asn 148, Asn 239, and Asn 301
  • Modification sites at PhosphoSitePlus

Other Protein References for ST6GALNAC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ST6GALNAC3 Gene

Gene Families for ST6GALNAC3 Gene

Protein Domains for ST6GALNAC3 Gene

Suggested Antigen Peptide Sequences for ST6GALNAC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NDV1

UniProtKB/Swiss-Prot:

SIA7C_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST6GALNAC3: view

Function for ST6GALNAC3 Gene

Molecular function for ST6GALNAC3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-(N-acetyl-D-galactosaminyl)-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein.
UniProtKB/Swiss-Prot Function:
Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity).

Enzyme Numbers (IUBMB) for ST6GALNAC3 Gene

Gene Ontology (GO) - Molecular Function for ST6GALNAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IBA,TAS --
genes like me logo Genes that share ontologies with ST6GALNAC3: view
genes like me logo Genes that share phenotypes with ST6GALNAC3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ST6GALNAC3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ST6GALNAC3 Gene

Localization for ST6GALNAC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST6GALNAC3 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST6GALNAC3 Gene COMPARTMENTS Subcellular localization image for ST6GALNAC3 gene
Compartment Confidence
golgi apparatus 5
extracellular 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ST6GALNAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
genes like me logo Genes that share ontologies with ST6GALNAC3: view

Pathways & Interactions for ST6GALNAC3 Gene

genes like me logo Genes that share pathways with ST6GALNAC3: view

UniProtKB/Swiss-Prot Q8NDV1-SIA7C_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for ST6GALNAC3 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000329214%0d%0a9606.ENSP00000318445%0d%0a9606.ENSP00000321343%0d%0a9606.ENSP00000345477%0d%0a9606.ENSP00000358565%0d%0a
Selected Interacting proteins: ENSP00000329214 for ST6GALNAC3 Gene via STRING

Gene Ontology (GO) - Biological Process for ST6GALNAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001574 ganglioside biosynthetic process IBA --
GO:0006486 protein glycosylation IEA --
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006687 glycosphingolipid metabolic process IDA 17123352
GO:0009100 glycoprotein metabolic process IDA 17123352
genes like me logo Genes that share ontologies with ST6GALNAC3: view

No data available for SIGNOR curated interactions for ST6GALNAC3 Gene

Drugs & Compounds for ST6GALNAC3 Gene

(2) Additional Compounds for ST6GALNAC3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytidine monophosphate
  • 5'-CMP
  • 5-Cytidylate
  • 5-Cytidylic acid
  • CMP
  • Cytidine 5'-monophosphate
63-37-6
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-Acetylneuraminate
  • CMP-N-Acylneuraminate
  • CMP-NeuNAc
  • Cytidine 5'-monophosphate N-acetylneuraminic acid
  • Cytidine Monophosphate N-Acetylneuraminate
22-12-8
genes like me logo Genes that share compounds with ST6GALNAC3: view

Transcripts for ST6GALNAC3 Gene

Unigene Clusters for ST6GALNAC3 Gene

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC3 Gene

No ASD Table

Relevant External Links for ST6GALNAC3 Gene

GeneLoc Exon Structure for
ST6GALNAC3
ECgene alternative splicing isoforms for
ST6GALNAC3

Expression for ST6GALNAC3 Gene

mRNA expression in normal human tissues for ST6GALNAC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST6GALNAC3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.7).

Protein differential expression in normal tissues from HIPED for ST6GALNAC3 Gene

This gene is overexpressed in Plasma (44.9) and Adipocyte (22.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ST6GALNAC3 Gene



SOURCE GeneReport for Unigene cluster for ST6GALNAC3 Gene Hs.337040

genes like me logo Genes that share expression patterns with ST6GALNAC3: view

Protein tissue co-expression partners for ST6GALNAC3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ST6GALNAC3 Gene

Orthologs for ST6GALNAC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST6GALNAC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ST6GALNAC3 35
  • 93.44 (n)
  • 97.7 (a)
dog
(Canis familiaris)
Mammalia ST6GALNAC3 35
  • 93.2 (n)
  • 97.32 (a)
ST6GALNAC3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St6galnac3 35
  • 83.39 (n)
  • 85.25 (a)
St6galnac3 16
St6galnac3 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ST6GALNAC3 35
  • 99.34 (n)
  • 99.34 (a)
ST6GALNAC3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia St6galnac3 35
  • 82.84 (n)
  • 85.9 (a)
oppossum
(Monodelphis domestica)
Mammalia ST6GALNAC3 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
chicken
(Gallus gallus)
Aves ST6GALNAC3 35
  • 80.62 (n)
  • 86.38 (a)
ST6GALNAC3 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST6GALNAC3 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st6galnac3 35
  • 72.02 (n)
  • 75.41 (a)
zebrafish
(Danio rerio)
Actinopterygii st6galnac3 35
  • 63.06 (n)
  • 63.61 (a)
st6galnac3 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ST6Gal 36
  • 11 (a)
OneToMany
Species with no ortholog for ST6GALNAC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST6GALNAC3 Gene

ENSEMBL:
Gene Tree for ST6GALNAC3 (if available)
TreeFam:
Gene Tree for ST6GALNAC3 (if available)

Paralogs for ST6GALNAC3 Gene

Paralogs for ST6GALNAC3 Gene

(3) SIMAP similar genes for ST6GALNAC3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ST6GALNAC3: view

Variants for ST6GALNAC3 Gene

Sequence variations from dbSNP and Humsavar for ST6GALNAC3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs50564 -- 76,093,766(+) ctcct(A/G)tatat intron-variant
rs158620 -- 76,105,378(+) cctag(A/C)tgatt intron-variant
rs158621 -- 76,092,258(+) AATAC(A/G)TATTT intron-variant
rs167048 -- 76,103,713(-) cacta(G/T)aaact intron-variant
rs167049 -- 76,144,330(-) TATGG(C/T)TTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST6GALNAC3 Gene

Variant ID Type Subtype PubMed ID
nsv870968 CNV Gain 21882294
nsv871862 CNV Loss 21882294
nsv518927 CNV Loss 19592680
nsv522056 CNV Loss 19592680
nsv1488 CNV Loss 18451855
esv2667591 CNV Deletion 23128226
esv28849 CNV Loss 19812545
nsv870621 CNV Gain 21882294
nsv523526 CNV Loss 19592680
nsv1499 CNV Loss 18451855
esv2750007 CNV Deletion 23290073
esv2108639 CNV Deletion 18987734
esv2750018 CNV Deletion 23290073
nsv462006 CNV Loss 19166990
esv274979 CNV Loss 21479260
esv2750030 CNV Deletion 23290073
esv2659404 CNV Deletion 23128226
dgv52n67 CNV Loss 20364138
esv2750041 CNV Deletion 23290073
nsv462017 CNV Loss 19166990
nsv462028 CNV Loss 19166990
nsv470718 CNV Loss 18288195
dgv20n27 CNV Loss 19166990
nsv526433 CNV Loss 19592680
nsv508315 CNV Loss 20534489
esv2750052 CNV Deletion 23290073

Variation tolerance for ST6GALNAC3 Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.66; 93.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ST6GALNAC3 Gene

HapMap Linkage Disequilibrium report
ST6GALNAC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST6GALNAC3 Gene

Disorders for ST6GALNAC3 Gene

Relevant External Links for ST6GALNAC3

Genetic Association Database (GAD)
ST6GALNAC3
Human Genome Epidemiology (HuGE) Navigator
ST6GALNAC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ST6GALNAC3

No disorders were found for ST6GALNAC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST6GALNAC3 Gene

Publications for ST6GALNAC3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers. (PMID: 17123352) Senda M. … Furukawa K. (Biochem. J. 2007) 3 23
  3. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. (PMID: 15843597) Harduin-Lepers A. … Oriol R. (Glycobiology 2005) 3 23
  4. Molecular cloning and expression of human ST6GalNAc III: restricted tissue distribution and substrate specificity. (PMID: 16169874) Tsuchida A. … Furukawa K. (J. Biochem. 2005) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ST6GALNAC3 Gene

Sources for ST6GALNAC3 Gene

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