Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ST6GALNAC3 Gene

Aliases for ST6GALNAC3 Gene

  • ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 3 2 3 5
  • Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) C 2 3
  • ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 3 2 3
  • ST6 GalNAc Alpha-2,6-Sialyltransferase 3 2 3
  • GalNAc Alpha-2,6-Sialyltransferase III 3 4
  • Sialyltransferase 7C 3 4
  • ST6GALNAC III 2 4
  • ST6GALNACIII 3 4
  • SIAT7C 3 4
  • STY 3 4
  • ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltran 3
  • Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase III 3
  • Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 3 3
  • EC 2.4.99.7 61
  • EC 2.4.99.- 4
  • PRO7177 3
  • SIAT7-C 4

External Ids for ST6GALNAC3 Gene

Previous HGNC Symbols for ST6GALNAC3 Gene

  • SIAT7C

Previous GeneCards Identifiers for ST6GALNAC3 Gene

  • GC01P076253
  • GC01P076540
  • GC01P074670

Summaries for ST6GALNAC3 Gene

Entrez Gene Summary for ST6GALNAC3 Gene

  • ST6GALNAC3 belongs to a family of sialyltransferases that transfer sialic acids from CMP-sialic acid to terminal positions of carbohydrate groups in glycoproteins and glycolipids (Lee et al., 1999 [PubMed 10207017]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ST6GALNAC3 Gene

ST6GALNAC3 (ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 3) is a Protein Coding gene. Among its related pathways are Synthesis of substrates in N-glycan biosythesis and Glycosphingolipid biosynthesis - ganglio series. GO annotations related to this gene include sialyltransferase activity. An important paralog of this gene is ST6GALNAC4.

UniProtKB/Swiss-Prot for ST6GALNAC3 Gene

  • Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST6GALNAC3 Gene

Genomics for ST6GALNAC3 Gene

Regulatory Elements for ST6GALNAC3 Gene

Enhancers for ST6GALNAC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G076040 0.7 ENCODE 24.9 -33.9 -33857 1.6 PKNOX1 ZNF362 NRF1 CEBPB ZNF384 ZIC2 OSR2 ZFP69B ZNF610 ZNF692 ST6GALNAC3 LOC101927342 ACADM MSH4 ENSG00000230027 LOC105378806
GH01G076037 0.7 ENCODE 23.9 -36.5 -36456 2.4 SCRT1 PKNOX1 SIN3A FEZF1 ZNF843 HIC1 JUND PRDM6 SCRT2 ZNF580 ST6GALNAC3 LOC101927342 ENSG00000230027 LOC105378806
GH01G076074 1.2 FANTOM5 ENCODE 7.9 +0.8 808 3.1 ZNF133 INSM2 ZNF76 BRCA1 ZNF2 GLIS2 ZNF366 SCRT2 FOS ETV6 ST6GALNAC3 LOC101927342 GC01P076080
GH01G076052 0.6 ENCODE 12.8 -21.4 -21415 0.7 TEAD4 CTBP2 KDM1A REST PRDM4 RAD21 SP7 ST6GALNAC3 GC01M076064 ENSG00000230027
GH01G076002 0.3 FANTOM5 10.5 -71.8 -71762 0.2 ST6GALNAC3 SLC44A5 ASB17 MSH4 LOC105378806 ENSG00000230027
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ST6GALNAC3 on UCSC Golden Path with GeneCards custom track

Promoters for ST6GALNAC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000008624 196 1401 CBX3 ZNF133 INSM2 ZNF76 BRCA1 ZNF2 GLIS2 ZNF366 SP3 USF2

Genomic Location for ST6GALNAC3 Gene

Chromosome:
1
Start:
76,074,704 bp from pter
End:
76,634,601 bp from pter
Size:
559,898 bases
Orientation:
Plus strand

Genomic View for ST6GALNAC3 Gene

Genes around ST6GALNAC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST6GALNAC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST6GALNAC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST6GALNAC3 Gene

Proteins for ST6GALNAC3 Gene

  • Protein details for ST6GALNAC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDV1-SIA7C_HUMAN
    Recommended name:
    Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
    Protein Accession:
    Q8NDV1
    Secondary Accessions:
    • Q6PCE0
    • Q6UX29
    • Q8N259

    Protein attributes for ST6GALNAC3 Gene

    Size:
    305 amino acids
    Molecular mass:
    35395 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ST6GALNAC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ST6GALNAC3 Gene

Selected DME Specific Peptides for ST6GALNAC3 Gene

Q8NDV1:
  • HRFITEK
  • LSTGWFT
  • SHTSVPLLL

Post-translational modifications for ST6GALNAC3 Gene

  • Glycosylation at isoforms=2148, Asn239, and isoforms=301

Domains & Families for ST6GALNAC3 Gene

Gene Families for ST6GALNAC3 Gene

Protein Domains for ST6GALNAC3 Gene

Suggested Antigen Peptide Sequences for ST6GALNAC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NDV1

UniProtKB/Swiss-Prot:

SIA7C_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST6GALNAC3: view

Function for ST6GALNAC3 Gene

Molecular function for ST6GALNAC3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-(N-acetyl-D-galactosaminyl)-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein.
UniProtKB/Swiss-Prot Function:
Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity).

Enzyme Numbers (IUBMB) for ST6GALNAC3 Gene

Gene Ontology (GO) - Molecular Function for ST6GALNAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity TAS --
GO:0008373 sialyltransferase activity IEA,IDA 17123352
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ST6GALNAC3: view
genes like me logo Genes that share phenotypes with ST6GALNAC3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ST6GALNAC3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ST6GALNAC3 Gene

Localization for ST6GALNAC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST6GALNAC3 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST6GALNAC3 gene
Compartment Confidence
golgi apparatus 5
nucleus 4
extracellular 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ST6GALNAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST6GALNAC3: view

Pathways & Interactions for ST6GALNAC3 Gene

genes like me logo Genes that share pathways with ST6GALNAC3: view

UniProtKB/Swiss-Prot Q8NDV1-SIA7C_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for ST6GALNAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0006677 glycosylceramide metabolic process IDA 17123352
GO:0006687 glycosphingolipid metabolic process IDA 17123352
GO:0009100 glycoprotein metabolic process IDA 17123352
GO:0009311 oligosaccharide metabolic process IBA --
genes like me logo Genes that share ontologies with ST6GALNAC3: view

No data available for SIGNOR curated interactions for ST6GALNAC3 Gene

Drugs & Compounds for ST6GALNAC3 Gene

(1) Drugs for ST6GALNAC3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine monophosphate Experimental Pharma 0

(1) Additional Compounds for ST6GALNAC3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-Acetylneuraminate
  • CMP-N-Acylneuraminate
  • CMP-NeuNAc
  • Cytidine 5'-monophosphate N-acetylneuraminic acid
  • Cytidine Monophosphate N-Acetylneuraminate
22-12-8
genes like me logo Genes that share compounds with ST6GALNAC3: view

Transcripts for ST6GALNAC3 Gene

Unigene Clusters for ST6GALNAC3 Gene

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC3 Gene

No ASD Table

Relevant External Links for ST6GALNAC3 Gene

GeneLoc Exon Structure for
ST6GALNAC3
ECgene alternative splicing isoforms for
ST6GALNAC3

Expression for ST6GALNAC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST6GALNAC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST6GALNAC3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.7).

Protein differential expression in normal tissues from HIPED for ST6GALNAC3 Gene

This gene is overexpressed in Plasma (44.9) and Adipocyte (22.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ST6GALNAC3 Gene



Protein tissue co-expression partners for ST6GALNAC3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ST6GALNAC3 Gene:

ST6GALNAC3

SOURCE GeneReport for Unigene cluster for ST6GALNAC3 Gene:

Hs.337040

Evidence on tissue expression from TISSUES for ST6GALNAC3 Gene

  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with ST6GALNAC3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST6GALNAC3 Gene

Orthologs for ST6GALNAC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST6GALNAC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST6GALNAC3 34 35
  • 99.34 (n)
cow
(Bos Taurus)
Mammalia ST6GALNAC3 34
  • 93.44 (n)
dog
(Canis familiaris)
Mammalia ST6GALNAC3 34 35
  • 93.2 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 91 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
mouse
(Mus musculus)
Mammalia St6galnac3 34 16 35
  • 83.39 (n)
rat
(Rattus norvegicus)
Mammalia St6galnac3 34
  • 82.84 (n)
oppossum
(Monodelphis domestica)
Mammalia ST6GALNAC3 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ST6GALNAC3 34 35
  • 80.62 (n)
lizard
(Anolis carolinensis)
Reptilia ST6GALNAC3 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st6galnac3 34
  • 72.02 (n)
zebrafish
(Danio rerio)
Actinopterygii st6galnac3 34 35
  • 63.06 (n)
fruit fly
(Drosophila melanogaster)
Insecta ST6Gal 35
  • 11 (a)
OneToMany
Species where no ortholog for ST6GALNAC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST6GALNAC3 Gene

ENSEMBL:
Gene Tree for ST6GALNAC3 (if available)
TreeFam:
Gene Tree for ST6GALNAC3 (if available)

Paralogs for ST6GALNAC3 Gene

Paralogs for ST6GALNAC3 Gene

(3) SIMAP similar genes for ST6GALNAC3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ST6GALNAC3: view

Variants for ST6GALNAC3 Gene

Sequence variations from dbSNP and Humsavar for ST6GALNAC3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000000805 -- 76,393,828(+) GTCTT(C/T)AGTGC intron-variant
rs1000002911 -- 76,274,283(+) TTAAA(C/G)TTTTT intron-variant
rs1000004627 -- 76,626,847(+) GTAGC(C/T)TGTTC intron-variant
rs1000007555 -- 76,350,459(+) ACTGA(C/G)AGTTA intron-variant
rs1000008396 -- 76,090,052(+) AACTT(A/G)TCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST6GALNAC3 Gene

Variant ID Type Subtype PubMed ID
dgv197n100 CNV loss 25217958
dgv198n100 CNV gain 25217958
dgv20n27 CNV loss 19166990
dgv327n54 CNV loss 21841781
dgv52n67 CNV loss 20364138
dgv57e212 CNV loss 25503493
esv2108639 CNV deletion 18987734
esv2659404 CNV deletion 23128226
esv2667591 CNV deletion 23128226
esv274979 CNV loss 21479260
esv2750007 CNV deletion 23290073
esv2750018 CNV deletion 23290073
esv2750030 CNV deletion 23290073
esv2750041 CNV deletion 23290073
esv2750052 CNV deletion 23290073
esv28849 CNV loss 19812545
esv2995021 CNV deletion 24192839
esv3364194 CNV insertion 20981092
esv3564359 CNV deletion 23714750
esv3564381 CNV deletion 23714750
esv3577970 CNV loss 25503493
esv3577973 CNV loss 25503493
esv3581693 CNV gain 25503493
esv3586494 CNV loss 21293372
esv3586495 CNV loss 21293372
esv3586497 CNV loss 21293372
esv3586499 CNV gain 21293372
esv3586500 CNV loss 21293372
nsv1122366 CNV deletion 24896259
nsv1133867 CNV deletion 24896259
nsv1151562 CNV deletion 26484159
nsv1488 CNV deletion 18451855
nsv1499 CNV deletion 18451855
nsv462006 CNV loss 19166990
nsv462017 CNV loss 19166990
nsv462028 CNV loss 19166990
nsv470718 CNV loss 18288195
nsv508315 CNV deletion 20534489
nsv518927 CNV loss 19592680
nsv522056 CNV loss 19592680
nsv523526 CNV loss 19592680
nsv526433 CNV loss 19592680
nsv546584 CNV loss 21841781
nsv546585 CNV loss 21841781
nsv546586 CNV loss 21841781
nsv546587 CNV loss 21841781
nsv947432 CNV duplication 23825009
nsv997827 CNV loss 25217958

Variation tolerance for ST6GALNAC3 Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.66; 93.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ST6GALNAC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST6GALNAC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST6GALNAC3 Gene

Disorders for ST6GALNAC3 Gene

Relevant External Links for ST6GALNAC3

Genetic Association Database (GAD)
ST6GALNAC3
Human Genome Epidemiology (HuGE) Navigator
ST6GALNAC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ST6GALNAC3

No disorders were found for ST6GALNAC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST6GALNAC3 Gene

Publications for ST6GALNAC3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Genome-wide association identifies candidate genes that influence the human electroencephalogram. (PMID: 20421487) Hodgkinson C.A. … Goldman D. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 46 64
  3. Germline genomic variants associated with childhood acute lymphoblastic leukemia. (PMID: 19684603) Trevino L.R. … Relling M.V. (Nat. Genet. 2009) 3 46 64
  4. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl G.R. … Lerman C. (Arch. Gen. Psychiatry 2008) 3 46 64
  5. Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers. (PMID: 17123352) Senda M. … Furukawa K. (Biochem. J. 2007) 3 22 64

Products for ST6GALNAC3 Gene

Sources for ST6GALNAC3 Gene

Content
Loading form....