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ST6GALNAC3 Gene

protein-coding   GIFtS: 51
GCID: GC01P076540

ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide...

(Previous name: sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl...)
(Previous symbol: SIAT7C)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ST6
(Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide
Alpha-2,6-Sialyltransferase 31 2
     PRO71772
SIAT7C1 2 3 5     ST6GALNACIII2
ST6GalNAc III1 2 3     Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 32
Sialyltransferase 7
((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl
Galactosaminide Alpha-2,6-Sialyltransferase) C1 2
     Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase III2
Sialyltransferase 7C2 3     ST6
(Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide
Alpha-2,6-Sialyltran2
SIAT7-C2 3     EC 2.4.99.-3
STY2 3     ST6GalNAcIII3
GalNAc Alpha-2,6-Sialyltransferase III2 3     EC 2.4.99.78

External Ids:    HGNC: 193431   Entrez Gene: 2564352   Ensembl: ENSG000001840057   OMIM: 6101335   UniProtKB: Q8NDV13   

Export aliases for ST6GALNAC3 gene to outside databases

Previous GC identifers: GC01P076253 GC01P074670


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ST6GALNAC3 Gene:
ST6GALNAC3 belongs to a family of sialyltransferases that transfer sialic acids from CMP-sialic acid to terminal
positions of carbohydrate groups in glycoproteins and glycolipids (Lee et al., 1999 (PubMed 10207017)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for ST6GALNAC3 Gene:
ST6GALNAC3 (ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3) is a protein-coding gene. Diseases associated with ST6GALNAC3 include colon adenocarcinoma, and lymphoblastic leukemia. GO annotations related to this gene include sialyltransferase activity. An important paralog of this gene is ST6GAL2.

UniProtKB/Swiss-Prot: SIA7C_HUMAN, Q8NDV1
Function: Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an
alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids.
ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ST6GALNAC3 gene promoter:
         FOXF2   Lmo2   AP-4   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   E47   Gfi-1   Pax-3   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidST6GALNAC3 promoter sequence
   Search Chromatin IP Primers for ST6GALNAC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST6GALNAC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

ST6GALNAC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST6GALNAC3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P076540:  view genomic region     (about GC identifiers)

Start:
76,540,389 bp from pter      End:
77,100,286 bp from pter
Size:
559,898 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIA7C_HUMAN, Q8NDV1 (See protein sequence)
Recommended Name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3  
Size: 305 amino acids; 35395 Da
Secondary accessions: Q6PCE0 Q6UX29 Q8N259
Alternative splicing: 2 isoforms:  Q8NDV1-1   Q8NDV1-2   

Explore the universe of human proteins at neXtProt for ST6GALNAC3: NX_Q8NDV1

Explore proteomics data for ST6GALNAC3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn148, Asn239, Asn301
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for ST6GALNAC3 (Q8NDV1)
     HRFITEK  LSTGWFT  SHTSVPLLL 


    See ST6GALNAC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001153483.1  NP_694541.2  

    ENSEMBL proteins: 
     ENSP00000329214  
    Reactome Protein details: Q8NDV1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ST3G: Sialyltransferases

    1 InterPro protein domain:
     IPR001675 Glyco_trans_29

    Graphical View of Domain Structure for InterPro Entry Q8NDV1

    ProtoNet protein and cluster: Q8NDV1

    1 Blocks protein domain: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIA7C_HUMAN, Q8NDV1
    Similarity: Belongs to the glycosyltransferase 29 family


    ST6GALNAC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIA7C_HUMAN, Q8NDV1
    Function: Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an
    alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids.
    ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity)
    Catalytic activity: CMP-N-acetylneuraminate +
    alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-(N-acetyl-D-galactosaminyl)-glycoprotein = CMP +
    alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein

         Enzyme Numbers (IUBMB): EC 2.4.99.-1 EC 2.4.99.72

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008373sialyltransferase activity IDA17123352
         
    ST6GALNAC3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ST6GALNAC3
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    hsa-miR-142-5p hsa-miR-193a-3p hsa-miR-300 hsa-miR-513a-5p hsa-miR-106a hsa-miR-128 hsa-miR-93 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidST6GALNAC3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST6GALNAC3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIA7C_HUMAN, Q8NDV1: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular3
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0016021integral component of membrane IEA--

    ST6GALNAC3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ST6GALNAC3 About    
    See pathways by source

    SuperPathContained pathways About
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.47
    Termination of O-glycan biosynthesis0.38
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    3Glycosphingolipid biosynthesis - ganglio series
    Glycosphingolipid biosynthesis - ganglio series0.53
    4Metabolism
    Metabolic pathways0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for ST6GALNAC3
        Sialic acid metabolism
    Termination of O-glycan biosynthesis


    2 Kegg Pathways  (Kegg details for ST6GALNAC3):
        Glycosphingolipid biosynthesis - ganglio series
    Metabolic pathways

    UniProtKB/Swiss-Prot: SIA7C_HUMAN, Q8NDV1
    Pathway: Protein modification; protein glycosylation


    ST6GALNAC3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ST6GALNAC3
    Interactions:

        Search GeneGlobe Interaction Network for ST6GALNAC3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ST6GALNAC3 (ENSP000003292144) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ST3GAL1ENSP000003184454STRING: ENSP00000318445
    ST3GAL2ENSP000003454774STRING: ENSP00000345477
    ST8SIA5ENSP000003213434STRING: ENSP00000321343
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation IEA--
    GO:0006677glycosylceramide metabolic process IDA17123352
    GO:0006687glycosphingolipid metabolic process IDA17123352
    GO:0009100glycoprotein metabolic process IDA17123352
    GO:0097503sialylation IDA17123352

    ST6GALNAC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for ST6GALNAC3 (SIA7C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ST6GALNAC3 gene (2 alternative transcripts): 
    NM_001160011.1  NM_152996.2  

    Unigene Cluster for ST6GALNAC3:

    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
    Hs.337040  [show with all ESTs]
    Unigene Representative Sequence: BX648274
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328299(uc001dhh.2 uc010orh.1) ENST00000464140(uc001dhg.4)

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    Selected qRT-PCR Assays for microRNAs that regulate ST6GALNAC3 (see all 38):
    hsa-miR-142-5p hsa-miR-193a-3p hsa-miR-300 hsa-miR-513a-5p hsa-miR-106a hsa-miR-128 hsa-miR-93 hsa-miR-330-3p
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    Additional mRNA sequence: 

    AJ507291.1 AK091215.1 AK297363.1 AY358540.1 BC039520.1 BC059363.1 BX648274.1 

    3 DOTS entries:

    DT.91878066  DT.97788329  DT.121402282 

    Selected AceView cDNA sequences (see all 35):

    NM_152996 AX746855 AA363936 AJ507291 AA876210 AA887393 AY358540 AA377469 
    BX280331 AI052511 AK091215 AA329850 BM547511 BP360943 AA922455 CB989542 
    BC059363 BM997957 BX648274 BC039520 AA188674 BQ006088 AW963951 AA205722 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ST6GALNAC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ST6GALNAC3 Expression
    About this image


    ST6GALNAC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Umbilical Cord (Extraembryonic Tissues)
             Wharton's jelly-derived stem cells
     
     Bone (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Inner Cell Mass (Early Embryonic Tissues)
             C2a
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
    ST6GALNAC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ST6GALNAC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.337040
        Custom PCR Arrays for ST6GALNAC3
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ST6GALNAC3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St6galnac31 , 5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more1, 5 83.39(n)1
    85.25(a)1
      3 (77.82 cM)5
    204471  NM_011372.21  NP_035502.11 
     1532054055 
    chicken
    (Gallus gallus)
    Aves ST6GALNAC31 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more 80.62(n)
    86.38(a)
      404746  XM_422394.4  XP_422394.4 
    lizard
    (Anolis carolinensis)
    Reptilia ST6GALNAC36
    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl...
    83(a)
    1 ↔ 1
    GL343194.1(3537914-3923449)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia st6galnac31 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more 72.02(n)
    75.41(a)
      100495364  XM_002936087.2  XP_002936133.2 
    zebrafish
    (Danio rerio)
    Actinopterygii st6galnac31 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more 63.06(n)
    63.61(a)
      322609  NM_212625.2  NP_997790.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ST6Gal6
    Sialyltransferase
    11(a)
    1 → many
    2R(20578945-20581909)


    ENSEMBL Gene Tree for ST6GALNAC3 (if available)
    TreeFam Gene Tree for ST6GALNAC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ST6GALNAC3 gene
    ST6GAL22  ST6GALNAC52  ST6GAL12  ST6GALNAC42  ST6GALNAC62  
    3 SIMAP similar genes for ST6GALNAC3 using alignment to 1 protein entry:     SIA7C_HUMAN:
    ST6GALNAC4    ST6GALNAC5    ST6GALNAC6

    ST6GALNAC3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ST6GALNAC3 (see all 10633)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs12514651,2
    C,F,A,H--76538396(+) CACAAG/ATCTGT 2 -- us2k1106Minor allele frequency- A:0.16NS EA NA PA EU CA WA CSA 6814
    rs1808931391,2
    --76538450(+) AAAAAC/GTGCTC 2 -- us2k10--------
    rs1390085011,2
    --76538457(+) GCTCAC/TAGTGC 2 -- us2k10--------
    rs1175978321,2
    F--76538568(+) AAACTT/GGATCA 2 -- us2k11Minor allele frequency- G:0.01EA 120
    rs1837490851,2
    --76538663(+) GAACGA/TTGTGC 2 -- us2k10--------
    rs1406211521,2
    --76538728(+) GGAGGC/GCTTCC 2 -- us2k10--------
    rs1504726611,2
    --76538816(+) GTCAGC/GTGTTT 2 -- us2k10--------
    rs1907756691,2
    --76538976(+) AAGGTC/TTTCAA 2 -- us2k10--------
    rs1820140811,2
    --76539037(+) TTTAGC/TAGTGG 2 -- us2k10--------
    rs773790541,2
    C,F--76539092(+) AATGAA/GATACT 2 -- us2k11Minor allele frequency- G:0.01WA 118

    HapMap Linkage Disequilibrium report for ST6GALNAC3 (76540389 - 76790389 bp, first 250kb of ST6GALNAC3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ST6GALNAC3 (see all 26):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659404CNV Deletion23128226
    esv2750030CNV Deletion23290073
    esv2108639CNV Deletion18987734
    esv2667591CNV Deletion23128226
    esv2750041CNV Deletion23290073
    esv2750018CNV Deletion23290073
    esv2750052CNV Deletion23290073
    esv2750007CNV Deletion23290073
    nsv462028CNV Loss19166990
    dgv20n27CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610133    OMIM disorders: --

    4 diseases for ST6GALNAC3:    
    About MalaCards
    colon adenocarcinoma    lymphoblastic leukemia    adenocarcinoma    leukemia


    ST6GALNAC3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ST6GALNAC3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma renal cell 40.2 1 17123352 (1)

    Genetic Association Database (GAD): ST6GALNAC3
    Human Genome Epidemiology (HuGE) Navigator: ST6GALNAC3 (3 documents)

    Export disorders for ST6GALNAC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ST6GALNAC3 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with ST6GALNAC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Genome-wide association identifies candidate genes that influence the human electroencephalogram. (PubMed id 20421487)1, 4 Hodgkinson C.A....Goldman D. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    3. Germline genomic variants associated with childhood acute lymphoblastic leukemia. (PubMed id 19684603)1, 4 Trevino L.R.... Relling M.V. (Nat. Genet. 2009)
    4. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers. (PubMed id 17123352)1, 9 Senda M.... Furukawa K. (Biochem. J. 2007)
    8. Molecular cloning and expression of human ST6GalNAc III: restricted tissue distribution and substrate specificity. (PubMed id 16169874)1, 9 Tsuchida A....Furukawa K. (J. Biochem. 2005)
    9. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. (PubMed id 15843597)1, 9 Harduin-Lepers A.... Oriol R. (Glycobiology 2005)
    10. Genome-wide association study of liver enzymes in korean children. (PubMed id 24124411)1 Park T.J....Lee J.Y. (amp 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 256435 HGNC: 19343 AceView: SIAT7C Ensembl:ENSG00000184005 euGenes: HUgn256435
    ECgene: ST6GALNAC3 Kegg: 256435 H-InvDB: ST6GALNAC3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ST6GALNAC3 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST6GALNAC3
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_632

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ST6GALNAC3 gene:
    Search GeneIP for patents involving ST6GALNAC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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