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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ST6GALNAC3 Gene

protein-coding   GIFtS: 52
GCID: GC01P076540

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide...

(Previous name: sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl...)
(Previous symbol: SIAT7C)
 Explore 4 diseases affiliated with
ST6GALNAC3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ST6GALNAC3    

Aliases
for ST6GALNAC3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ST6
(Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide
Alpha-2,6-Sialyltransferase 31 2
     PRO71772
SIAT7C1 2 3     ST6GALNACIII2
Sialyltransferase 7
((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide
Alpha-2,6-Sialyltransferase) C1 2
     Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 32
Sialyltransferase 7C2 3     Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase III2
ST6GalNAc III2 3     ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide
Alpha-2,6-Sialyltran2
SIAT7-C2 3     EC 2.4.99.-3
STY2 3     ST6GalNAcIII3
GalNAc Alpha-2,6-Sialyltransferase III2 3     EC 2.4.99.78

External Ids:    HGNC: 193431   Entrez Gene: 2564352   Ensembl: ENSG000001840057   OMIM: 6101335   UniProtKB: Q8NDV13   

Export aliases for ST6GALNAC3 gene to outside databases

Previous GC identifers: GC01P076253 GC01P074670


Summaries
for ST6GALNAC3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ST6GALNAC3:
ST6GALNAC3 belongs to a family of sialyltransferases that transfer sialic acids from CMP-sialic acid to terminal
positions of carbohydrate groups in glycoproteins and glycolipids (Lee et al., 1999 (PubMed 10207017)).(supplied by
OMIM, Mar 2008)

UniProtKB/Swiss-Prot: SIA7C_HUMAN, Q8NDV1
Function: Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to
GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers
glycolipids to glycoproteins (By similarity)




Genomic Views
for ST6GALNAC3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ST6GALNAC3 gene promoter:
         FOXF2   Lmo2   AP-4   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   E47   Gfi-1   Pax-3   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ST6GALNAC3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ST6GALNAC3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST6GALNAC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

ST6GALNAC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST6GALNAC3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P076540:  view genomic region     (about GC identifiers)

Start:
 76,540,389 bp from pter      End:
 77,100,286 bp from pter
Size:
 559,898 bases      Orientation:
 plus strand

Proteins
for ST6GALNAC3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SIA7C_HUMAN, Q8NDV1 (See protein sequence)
Recommended Name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3  
Size: 305 amino acids; 35395 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
Secondary accessions: Q6PCE0 Q6UX29 Q8N259
Alternative splicing: 2 isoforms:  Q8NDV1-1   Q8NDV1-2   

Explore the universe of human proteins at neXtProt for ST6GALNAC3: NX_Q8NDV1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NDV1

    • 3 DME Specific Peptides for ST6GALNAC3 (Q8NDV1)
     HRFITEK  LSTGWFT  SHTSVPLLL 

    ST6GALNAC3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001153483.1  NP_694541.2  

    ENSEMBL proteins: 
     ENSP00000329214  
    Reactome Protein details: Q8NDV1
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 2): ST6GALNAC3
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    Novus Biologicals ST6GALNAC3 Protein
    Novus Biologicals ST6GALNAC3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ST6GALNAC3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030173integral to Golgi membrane IEA--


    ST6GALNAC3 for ontologies           About GeneDecksing



    ST6GALNAC3 Antibody Products: 
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    Uscn ELISAs and CLIAs for ST6GALNAC3

    Protein Domains /
    Families
    for ST6GALNAC3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ST6GALNAC3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001675 Glyco_trans_29

    Graphical View of Domain Structure for InterPro Entry Q8NDV1

    ProtoNet protein and cluster: Q8NDV1

    1 Blocks protein family: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIA7C_HUMAN, Q8NDV1
    Similarity: Belongs to the glycosyltransferase 29 family


    Function
    for ST6GALNAC3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SIA7C_HUMAN, Q8NDV1
    Function: Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to
    GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers
    glycolipids to glycoproteins (By similarity)
    Catalytic activity: CMP-N-acetylneuraminate +
    alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-(N-acetyl-D-galactosaminyl)-glycoprotein = CMP +
    alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein

    Enzyme Numbers (IUBMB): EC 2.4.99.-1 EC 2.4.99.72

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST6GALNAC3
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate ST6GALNAC3 (see all 38):
    hsa-miR-142-5p hsa-miR-193a-3p hsa-miR-300 hsa-miR-513a-5p hsa-miR-106a hsa-miR-128 hsa-miR-93 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmid: ST6GALNAC3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ST6GALNAC3 (see all 7)
    OriGene shRNA RFP: ST6GALNAC3
    OriGene siRNA: ST6GALNAC3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST6GALNAC3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ST6GALNAC3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ST6GALNAC3 (see all 4)
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    Cell Line
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    Search LifeMap BioReagents cell lines for ST6GALNAC3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST6GALNAC3

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008373sialyltransferase activity IDA17123352


    ST6GALNAC3 for ontologies           About GeneDecksing



    Pathways & Interactions
    for ST6GALNAC3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein
    		Termination of O-glycan biosynthesis0.69
    		O-linked glycosylation of mucins0.28
    2Asparagine N-linked glycosylation
    		Post-translational protein modification0.44
    		Metabolism of proteins0.15
    3Ganglio Sphingolipid Metabolism
    		Glycosphingolipid biosynthesis - ganglio series0.53
    4Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for ST6GALNAC3
        O-linked glycosylation of mucins
    Metabolism of proteins
    Post-translational protein modification
    Termination of O-glycan biosynthesis


    2         Kegg Pathways  (Kegg details for ST6GALNAC3):
        Glycosphingolipid biosynthesis - ganglio series
    Metabolic pathways

    UniProtKB/Swiss-Prot: SIA7C_HUMAN, Q8NDV1
    Pathway: Protein modification; protein glycosylation


    ST6GALNAC3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ST6GALNAC3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ST6GALNAC3 (ENSP000003292144) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ST3GAL1ENSP000003184454STRING: ENSP00000318445
    ST3GAL2ENSP000003454774STRING: ENSP00000345477
    ST8SIA5ENSP000003213434STRING: ENSP00000321343
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation IEA--
    GO:0006677glycosylceramide metabolic process IDA17123352
    GO:0006687glycosphingolipid metabolic process IDA17123352
    GO:0009100glycoprotein metabolic process IDA17123352


    ST6GALNAC3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ST6GALNAC3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ST6GALNAC3
    Search CenterWatch for drugs/clinical trials and news about ST6GALNAC3 / SIA7C 

    Transcripts
    for ST6GALNAC3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ST6GALNAC3 gene (2 alternative transcripts): 
    NM_001160011.1  NM_152996.2  

    Unigene Clusters for ST6GALNAC3:

    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
    Hs.337040  [show with all ESTs], Hs.677241 , Hs.679096  [show with all ESTs]
    Unigene Representative Sequences: BX648274, AK023731, AK130749
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328299(uc001dhh.2 uc010orh.1) ENST00000464140(uc001dhg.4)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST6GALNAC3
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate ST6GALNAC3 (see all 38):
    hsa-miR-142-5p hsa-miR-193a-3p hsa-miR-300 hsa-miR-513a-5p hsa-miR-106a hsa-miR-128 hsa-miR-93 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmid: ST6GALNAC3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ST6GALNAC3 (see all 7)
    OriGene shRNA RFP: ST6GALNAC3
    OriGene siRNA: ST6GALNAC3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST6GALNAC3
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ST6GALNAC3 (NM_152996)
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST6GALNAC3

    Additional cDNA sequence: AK130749.1 

    5 DOTS entries:

    DT.91878066  DT.97788329  DT.91931046  DT.91939670  DT.121402282 

    24/35 AceView cDNA sequences (see all 35):

    AI052511 AA887393 AA363936 AA377469 AY358540 AK091215 AJ507291 AX746855 
    AA876210 BX280331 NM_152996 BC059363 BC039520 AA922455 AA188674 BX648274 
    BP360943 BM997957 BM547511 CB989542 AA329850 AW963951 AA205722 BQ006088 

    GeneLoc Exon Structure


    Expression
    for ST6GALNAC3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ST6GALNAC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ST6GALNAC3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PancreasIslets of LangerhansMature Beta CellsPancreas
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    HyStem+TGF?3+GDF5-induced MEL2 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage

    See ST6GALNAC3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ST6GALNAC3

    SOURCE GeneReport for Unigene clusters: Hs.337040 Hs.677241 Hs.679096
        SABiosciences Custom PCR Arrays for ST6GALNAC3
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST6GALNAC3

    Orthologs
    for ST6GALNAC3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ST6GALNAC3 gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ST6GALNAC31 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more 80.62(n)
    86.38(a)    		   404746  XM_422394.3  XP_422394.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ST6GALNAC36
    		 --
    		 83(a)
    		 1 ↔ 1
    		 GL343194.1(3691220-3923446)
    zebrafish
    (Danio rerio)    		 Actinopterygii st6galnac31 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more 63.06(n)
    63.61(a)    		   322609  NM_212625.2  NP_997790.1 


    ENSEMBL Gene Tree for ST6GALNAC3 (if available)
    TreeFam Gene Tree for ST6GALNAC3 (if available) 

    Paralogs
    for ST6GALNAC3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ST6GALNAC3 gene
    ST6GAL22  ST6GAL12  ST6GALNAC52  ST6GALNAC42  ST6GALNAC62  
    3 SIMAP similar genes for ST6GALNAC3 using alignment to 1 protein entry:     SIA7C_HUMAN:
    ST6GALNAC4    ST6GALNAC5    ST6GALNAC6

    ST6GALNAC3 for paralogs           About GeneDecksing



    Genomic Variants
    for ST6GALNAC3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/9280 NCBI SNPs in ST6GALNAC3 are shown (see all 9280)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs12514651,2
    		C,F,A,H,--76538396(+) CACAAG/ATCTGT 2 -- us2k1106Minor allele frequency- A:0.16NS EA NA PA EU CA WA CSA 6814
    rs1808931391,2
    		--76538450(+) AAAAAC/GTGCTC 2 -- us2k10--------
    rs1390085011,2
    		--76538457(+) GCTCAC/TAGTGC 2 -- us2k10--------
    rs1175978321,2
    		--76538568(+) AAACTT/GGATCA 2 -- us2k11Minor allele frequency- G:0.01EA 120
    rs1837490851,2
    		--76538663(+) GAACGA/TTGTGC 2 -- us2k10--------
    rs1406211521,2
    		--76538728(+) GGAGGC/GCTTCC 2 -- us2k10--------
    rs1504726611,2
    		--76538816(+) GTCAGC/GTGTTT 2 -- us2k10--------
    rs1907756691,2
    		--76538976(+) AAGGTC/TTTCAA 2 -- us2k10--------
    rs1820140811,2
    		--76539037(+) TTTAGC/TAGTGG 2 -- us2k10--------
    rs773790541,2
    		--76539092(+) AATGAA/GATACT 2 -- us2k11Minor allele frequency- G:0.01WA 118

    HapMap Linkage Disequilibrium report for ST6GALNAC3 (76540389 - 76790389 bp, first 250kb of ST6GALNAC3)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for ST6GALNAC3
         3 CNVs: 53715 64050 29832
         1 Indel: 39623

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    Disorders / Diseases
    for ST6GALNAC3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ST6GALNAC3 for disorders           About GeneDecksing

    OMIM gene information: 610133    OMIM disorders: --

    4 diseases for ST6GALNAC3:    About MalaCards
    lymphoblastic leukemia    colon adenocarcinoma    adenocarcinoma    leukemia

    1 Novoseek disease relationship for ST6GALNAC3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma renal cell 40.2 1 17123352 (1)

    Human Genome Epidemiology (HuGE) Navigator: ST6GALNAC3 (3 documents)

    Export disorders for ST6GALNAC3 gene to outside databases

    Publications
    for ST6GALNAC3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ST6GALNAC3 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with ST6GALNAC3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    3. Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers. (PubMed id 17123352)1, 9 Senda M....Furukawa K. (2007)
    4. Molecular cloning and expression of human ST6GalNAc III: restricted tissue distribution and substrate specificity. (PubMed id 16169874)1, 9 Tsuchida A....Furukawa K. (2005)
    5. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. (PubMed id 15843597)1, 9 Harduin-Lepers A.... Oriol R. (2005)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. Genome-wide association identifies candidate genes th at influence the human electroencephalogram. (PubMed id 20421487)1 Hodgkinson C.A....Goldman D. (2010)
    8. Germline genomic variants associated with childhood a cute lymphoblastic leukemia. (PubMed id 19684603)1 TreviA+o L.R....Relling M.V. (2009)
    9. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1 Uhl G.R....Lerman C. (2008)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    External Searches for ST6GALNAC3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ST6GALNAC3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 256435 HGNC: 19343 AceView: SIAT7C Ensembl:ENSG00000184005 euGenes: HUgn256435
    ECgene: ST6GALNAC3 Kegg: 256435 H-InvDB: ST6GALNAC3

    Other Databases showing ST6GALNAC3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ST6GALNAC3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ST6GALNAC3 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST6GALNAC3
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_632

    Intellectual Property
    for ST6GALNAC3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ST6GALNAC3 gene:
    Search GeneIP for patents involving ST6GALNAC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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