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Aliases for ST6GALNAC2 Gene

Aliases for ST6GALNAC2 Gene

  • ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 2 3 5
  • ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 2 3
  • ST6 GalNAc Alpha-2,6-Sialyltransferase 2 2 3
  • GalNAc Alpha-2,6-Sialyltransferase II 3 4
  • Sialyltransferase-Like 1 2 3
  • Sialyltransferase 7B 3 4
  • ST6GalNAc II 3 4
  • ST6GalNAcII 3 4
  • SIAT7-B 3 4
  • SIAT7B 3 4
  • SIATL1 3 4
  • STHM 3 4
  • Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) B 3
  • Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) 2
  • (Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase 3
  • Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide B 3
  • (Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide B 3
  • Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 3
  • ST6GALNAC2, Alpha-2,6-Sialyltransferase 2 3
  • EC 2.4.99.- 4
  • ST6GalNAII 3
  • SAITL1 3
  • SIAT7 3

External Ids for ST6GALNAC2 Gene

Previous HGNC Symbols for ST6GALNAC2 Gene

  • SIAT7
  • SIAT7B
  • SIATL1

Previous GeneCards Identifiers for ST6GALNAC2 Gene

  • GC17M072074
  • GC17M074561
  • GC17M069989

Summaries for ST6GALNAC2 Gene

Entrez Gene Summary for ST6GALNAC2 Gene

  • ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion, and protein targeting (Samyn-Petit et al., 2000 [PubMed 10742600]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ST6GALNAC2 Gene

ST6GALNAC2 (ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2) is a Protein Coding gene. Among its related pathways are O-linked glycosylation and Transport to the Golgi and subsequent modification. GO annotations related to this gene include sialyltransferase activity. An important paralog of this gene is ST6GALNAC1.

Gene Wiki entry for ST6GALNAC2 Gene

Additional gene information for ST6GALNAC2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST6GALNAC2 Gene

Genomics for ST6GALNAC2 Gene

Regulatory Elements for ST6GALNAC2 Gene

Enhancers for ST6GALNAC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H076584 1 ENCODE 23.6 +1.5 1518 2.4 ZFP64 ARID4B SIN3A ZNF2 ZNF121 GLIS2 KLF7 SP3 MXD4 PPARG ST6GALNAC2 UNK EXOC7 MGAT5B ENSG00000284526
GH17H076586 0.9 ENCODE 22.9 +0.0 23 0.4 PKNOX1 ZNF76 KLF17 ZNF2 ZNF121 ZNF366 SCRT2 TSHZ1 ZEB2 ZNF398 ST6GALNAC2 ENSG00000284526
GH17H076566 1.2 Ensembl ENCODE 16.8 +19.1 19144 2.2 PKNOX1 FOXA2 MLX THRB RARA ZNF766 KLF7 RUNX3 THAP11 PAF1 ENSG00000267342 ST6GALNAC2 UNK TRIM65 PRCD ENSG00000267546 SRSF2 ENSG00000267078 PIR42434
GH17H076569 1.1 Ensembl ENCODE 18 +16.8 16832 1 ELF3 ARID4B DMAP1 RAD21 THRB ZSCAN9 RARA GLIS2 THAP11 SP5 ST6GALNAC2 PRCD ENSG00000267543 ENSG00000267078 ENSG00000284526
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ST6GALNAC2 on UCSC Golden Path with GeneCards custom track

Promoters for ST6GALNAC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098604 1256 1401 ZFP64 ARID4B SIN3A ZNF2 ZNF121 GLIS2 KLF7 SP3 MXD4 PPARG

Genomic Locations for ST6GALNAC2 Gene

Genomic Locations for ST6GALNAC2 Gene
21,578 bases
Minus strand

Genomic View for ST6GALNAC2 Gene

Genes around ST6GALNAC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST6GALNAC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST6GALNAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST6GALNAC2 Gene

Proteins for ST6GALNAC2 Gene

  • Protein details for ST6GALNAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
    Protein Accession:
    Secondary Accessions:
    • Q12971

    Protein attributes for ST6GALNAC2 Gene

    374 amino acids
    Molecular mass:
    41939 Da
    Quaternary structure:
    No Data Available
    • Aberrant O-galactosylation of IgA1 molecules plays a role in the development and progression of IgA nephropathy (IgAN). Genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation, disease predisposition, and disease severity, and may contribute to the polygenic nature of IgAN.

neXtProt entry for ST6GALNAC2 Gene

Post-translational modifications for ST6GALNAC2 Gene

  • Glycosylation at posLast=8585, Asn130, and Asn161
  • Modification sites at PhosphoSitePlus

Other Protein References for ST6GALNAC2 Gene

No data available for DME Specific Peptides for ST6GALNAC2 Gene

Domains & Families for ST6GALNAC2 Gene

Gene Families for ST6GALNAC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ST6GALNAC2 Gene

Suggested Antigen Peptide Sequences for ST6GALNAC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 29 family.
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST6GALNAC2: view

Function for ST6GALNAC2 Gene

Molecular function for ST6GALNAC2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
CMP-N-acetylneuraminate + glycano-beta-D-galactosyl-1,3-(N-acetyl-D-galactosaminyl)-glycoprotein = CMP + glycano-beta-D-galactosyl-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein.

Enzyme Numbers (IUBMB) for ST6GALNAC2 Gene

Gene Ontology (GO) - Molecular Function for ST6GALNAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity TAS --
GO:0008373 sialyltransferase activity IEA,TAS --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ST6GALNAC2: view
genes like me logo Genes that share phenotypes with ST6GALNAC2: view

Animal Models for ST6GALNAC2 Gene

MGI Knock Outs for ST6GALNAC2:

Animal Model Products

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ST6GALNAC2 Gene

Localization for ST6GALNAC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST6GALNAC2 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST6GALNAC2 gene
Compartment Confidence
golgi apparatus 4
extracellular 2
plasma membrane 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ST6GALNAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST6GALNAC2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ST6GALNAC2 Gene

Pathways & Interactions for ST6GALNAC2 Gene

genes like me logo Genes that share pathways with ST6GALNAC2: view

UniProtKB/Swiss-Prot Q9UJ37-SIA7B_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for ST6GALNAC2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)
Selected Interacting proteins: ENSP00000225276 Q9UJ37-SIA7B_HUMAN for ST6GALNAC2 Gene via STRING IID MINT

Gene Ontology (GO) - Biological Process for ST6GALNAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0009311 oligosaccharide metabolic process IBA --
GO:0016266 O-glycan processing TAS --
GO:0018279 protein N-linked glycosylation via asparagine IBA --
GO:0097503 sialylation IEA,IBA --
genes like me logo Genes that share ontologies with ST6GALNAC2: view

No data available for SIGNOR curated interactions for ST6GALNAC2 Gene

Drugs & Compounds for ST6GALNAC2 Gene

(1) Drugs for ST6GALNAC2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine monophosphate Experimental Pharma 0

(1) Additional Compounds for ST6GALNAC2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-Acetylneuraminate
  • CMP-N-Acylneuraminate
  • CMP-NeuNAc
  • Cytidine 5'-monophosphate N-acetylneuraminic acid
  • Cytidine Monophosphate N-Acetylneuraminate
genes like me logo Genes that share compounds with ST6GALNAC2: view

Transcripts for ST6GALNAC2 Gene

Unigene Clusters for ST6GALNAC2 Gene

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
SP1: - - - -
SP2: -
SP3: - -
SP5: -

Relevant External Links for ST6GALNAC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ST6GALNAC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST6GALNAC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST6GALNAC2 Gene

This gene is overexpressed in Nerve - Tibial (x7.4), Testis (x6.1), and Whole Blood (x5.2).

Protein differential expression in normal tissues from HIPED for ST6GALNAC2 Gene

This gene is overexpressed in Synovial fluid (55.7) and Placenta (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ST6GALNAC2 Gene

Protein tissue co-expression partners for ST6GALNAC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ST6GALNAC2 Gene:


SOURCE GeneReport for Unigene cluster for ST6GALNAC2 Gene:


mRNA Expression by UniProt/SwissProt for ST6GALNAC2 Gene:

Tissue specificity: Expressed in skeletal muscle, heart, kidney, placenta, lung and leukocytes.

Evidence on tissue expression from TISSUES for ST6GALNAC2 Gene

  • Skin(4.3)
genes like me logo Genes that share expression patterns with ST6GALNAC2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ST6GALNAC2 Gene

Orthologs for ST6GALNAC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST6GALNAC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ST6GALNAC2 33 34
  • 97.95 (n)
(Canis familiaris)
Mammalia ST6GALNAC2 33 34
  • 85.83 (n)
(Bos Taurus)
Mammalia ST6GALNAC2 33 34
  • 83.82 (n)
(Mus musculus)
Mammalia St6galnac2 33 16 34
  • 79.36 (n)
(Rattus norvegicus)
Mammalia St6galnac2 33
  • 79.09 (n)
(Ornithorhynchus anatinus)
Mammalia ST6GALNAC2 34
  • 65 (a)
(Monodelphis domestica)
Mammalia ST6GALNAC2 34
  • 59 (a)
(Gallus gallus)
Aves ST6GALNAC2 33 34
  • 63.54 (n)
(Anolis carolinensis)
Reptilia ST6GALNAC2 34
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia st6galnac2 33
  • 62.66 (n)
siat7b 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15681 33
(Danio rerio)
Actinopterygii st6galnac2 33
  • 59.31 (n)
  • 49 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11887 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4378 34
  • 22 (a)
Species where no ortholog for ST6GALNAC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST6GALNAC2 Gene

Gene Tree for ST6GALNAC2 (if available)
Gene Tree for ST6GALNAC2 (if available)

Paralogs for ST6GALNAC2 Gene

Paralogs for ST6GALNAC2 Gene

(2) SIMAP similar genes for ST6GALNAC2 Gene using alignment to 5 proteins: Pseudogenes for ST6GALNAC2 Gene

genes like me logo Genes that share paralogs with ST6GALNAC2: view

Variants for ST6GALNAC2 Gene

Sequence variations from dbSNP and Humsavar for ST6GALNAC2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000031746 -- 76,566,938(+) GCTGC(G/T)GCTTG intron-variant
rs1000093147 -- 76,586,256(+) GGGCC(C/G)GGCAC upstream-variant-2KB
rs1000111407 -- 76,571,112(+) TCCAG(C/T)CAAGC intron-variant
rs1000167981 -- 76,584,253(+) AGTGG(C/T)GCGAT intron-variant
rs1000392070 -- 76,577,060(+) TTTTT(C/T)TTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST6GALNAC2 Gene

Variant ID Type Subtype PubMed ID
nsv828107 CNV loss 20364138
nsv1071403 CNV deletion 25765185
esv3641291 CNV gain 21293372
esv3641290 CNV gain 21293372
esv28008 CNV loss 19812545

Variation tolerance for ST6GALNAC2 Gene

Residual Variation Intolerance Score: 60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ST6GALNAC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST6GALNAC2 Gene

Disorders for ST6GALNAC2 Gene

Relevant External Links for ST6GALNAC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ST6GALNAC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST6GALNAC2 Gene

Publications for ST6GALNAC2 Gene

  1. Interaction between variants of two glycosyltransferase genes in IgA nephropathy. (PMID: 19357720) Zhu L … Wang H (Kidney international 2009) 3 4 45 60
  2. Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells. (PMID: 10742600) Samyn-Petit B … Harduin-Lepers A (Biochimica et biophysica acta 2000) 3 4 22 60
  3. Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy. (PMID: 17480010) Li GS … Wang HY (Human mutation 2007) 3 45 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Identification and functional characterization of a human GalNAc [alpha]2,6-sialyltransferase with altered expression in breast cancer. (PMID: 11984005) Sotiropoulou G … Sager R (Molecular medicine (Cambridge, Mass.) 2002) 2 22 60

Products for ST6GALNAC2 Gene

Sources for ST6GALNAC2 Gene

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