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Aliases for ST6GALNAC2 Gene

Aliases for ST6GALNAC2 Gene

  • ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 2 3
  • SIAT7B 3 4 6
  • GalNAc Alpha-2,6-Sialyltransferase II 3 4
  • Sialyltransferase-Like 1 2 3
  • Sialyltransferase 7B 3 4
  • ST6GalNAc II 3 4
  • ST6GalNAcII 3 4
  • SIAT7-B 3 4
  • SIATL1 3 4
  • SAITL1 3 6
  • STHM 3 4
  • Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) B 3
  • Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) 2
  • (Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase 3
  • Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide B 3
  • (Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide B 3
  • Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 3
  • EC 2.4.99.- 4
  • ST6GalNAII 3
  • SIAT7 3

External Ids for ST6GALNAC2 Gene

Previous HGNC Symbols for ST6GALNAC2 Gene

  • SIAT7
  • SIAT7B
  • SIATL1

Previous GeneCards Identifiers for ST6GALNAC2 Gene

  • GC17M072074
  • GC17M074561
  • GC17M069989

Summaries for ST6GALNAC2 Gene

Entrez Gene Summary for ST6GALNAC2 Gene

  • ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion, and protein targeting (Samyn-Petit et al., 2000 [PubMed 10742600]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ST6GALNAC2 Gene

ST6GALNAC2 (ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2) is a Protein Coding gene. Diseases associated with ST6GALNAC2 include iga glomerulonephritis. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include sialyltransferase activity. An important paralog of this gene is ST3GAL4.

Gene Wiki entry for ST6GALNAC2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST6GALNAC2 Gene

Genomics for ST6GALNAC2 Gene

Regulatory Elements for ST6GALNAC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ST6GALNAC2 Gene

76,563,710 bp from pter
76,586,956 bp from pter
23,247 bases
Minus strand

Genomic View for ST6GALNAC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ST6GALNAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST6GALNAC2 Gene

Proteins for ST6GALNAC2 Gene

  • Protein details for ST6GALNAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
    Protein Accession:
    Secondary Accessions:
    • Q12971

    Protein attributes for ST6GALNAC2 Gene

    374 amino acids
    Molecular mass:
    41939 Da
    Quaternary structure:
    No Data Available
    • Aberrant O-galactosylation of IgA1 molecules plays a role in the development and progression of IgA nephropathy (IgAN). Genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation, disease predisposition, and disease severity, and may contribute to the polygenic nature of IgAN

neXtProt entry for ST6GALNAC2 Gene

Proteomics data for ST6GALNAC2 Gene at MOPED

Post-translational modifications for ST6GALNAC2 Gene

  • Glycosylation at Asn85, Asn130, and Asn161
  • Modification sites at PhosphoSitePlus

Other Protein References for ST6GALNAC2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ST6GALNAC2 Gene

Domains for ST6GALNAC2 Gene

Gene Families for ST6GALNAC2 Gene

  • ST3G :Sialyltransferases

Protein Domains for ST6GALNAC2 Gene

Suggested Antigen Peptide Sequences for ST6GALNAC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9UJ37
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST6GALNAC2: view

Function for ST6GALNAC2 Gene

Molecular function for ST6GALNAC2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: CMP-N-acetylneuraminate + glycano-beta-D-galactosyl-1,3-(N-acetyl-D-galactosaminyl)-glycoprotein = CMP + glycano-beta-D-galactosyl-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein

Enzyme Numbers (IUBMB) for ST6GALNAC2 Gene

Gene Ontology (GO) - Molecular Function for ST6GALNAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008373 sialyltransferase activity IEA --
genes like me logo Genes that share ontologies with ST6GALNAC2: view

Phenotypes for ST6GALNAC2 Gene

GenomeRNAi human phenotypes for ST6GALNAC2:
genes like me logo Genes that share phenotypes with ST6GALNAC2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ST6GALNAC2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ST6GALNAC2 Gene

Localization for ST6GALNAC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST6GALNAC2 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for ST6GALNAC2 Gene COMPARTMENTS Subcellular localization image for ST6GALNAC2 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ST6GALNAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane --
GO:0030173 integral component of Golgi membrane IEA --
genes like me logo Genes that share ontologies with ST6GALNAC2: view

Pathways for ST6GALNAC2 Gene

genes like me logo Genes that share pathways with ST6GALNAC2: view

UniProtKB/Swiss-Prot Q9UJ37-SIA7B_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for ST6GALNAC2 Gene

Gene Ontology (GO) - Biological Process for ST6GALNAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation --
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
genes like me logo Genes that share ontologies with ST6GALNAC2: view

Transcripts for ST6GALNAC2 Gene

Unigene Clusters for ST6GALNAC2 Gene

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ST6GALNAC2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
SP1: - - - -
SP2: -
SP3: - -
SP5: -

Relevant External Links for ST6GALNAC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ST6GALNAC2 Gene

mRNA expression in normal human tissues for ST6GALNAC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST6GALNAC2 Gene

This gene is overexpressed in Nerve - Tibial (7.4), Testis (6.1), and Whole Blood (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ST6GALNAC2 Gene

SOURCE GeneReport for Unigene cluster for ST6GALNAC2 Gene Hs.592105

mRNA Expression by UniProt/SwissProt for ST6GALNAC2 Gene

Tissue specificity: Expressed in skeletal muscle, heart, kidney, placenta, lung and leukocytes
genes like me logo Genes that share expressions with ST6GALNAC2: view

In Situ Assay Products

Orthologs for ST6GALNAC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST6GALNAC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ST6GALNAC2 35
  • 97.95 (n)
  • 96.79 (a)
  • 98 (a)
(Bos Taurus)
Mammalia ST6GALNAC2 35
  • 83.82 (n)
  • 81.5 (a)
  • 81 (a)
(Canis familiaris)
Mammalia ST6GALNAC2 35
  • 85.83 (n)
  • 82.35 (a)
  • 74 (a)
(Mus musculus)
Mammalia St6galnac2 35
  • 79.36 (n)
  • 75.07 (a)
St6galnac2 16
St6galnac2 36
  • 75 (a)
(Monodelphis domestica)
Mammalia ST6GALNAC2 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia ST6GALNAC2 36
  • 65 (a)
(Rattus norvegicus)
Mammalia St6galnac2 35
  • 79.09 (n)
  • 75.34 (a)
(Gallus gallus)
Aves ST6GALNAC2 35
  • 63.54 (n)
  • 61.39 (a)
  • 56 (a)
(Anolis carolinensis)
Reptilia ST6GALNAC2 36
  • 54 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15681 35
tropical clawed frog
(Silurana tropicalis)
Amphibia siat7b 35
st6galnac2 35
  • 62.66 (n)
  • 62.66 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11887 35
(Danio rerio)
Actinopterygii st6galnac2 35
  • 59.31 (n)
  • 57.3 (a)
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4378 36
  • 22 (a)
Species with no ortholog for ST6GALNAC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST6GALNAC2 Gene

Gene Tree for ST6GALNAC2 (if available)
Gene Tree for ST6GALNAC2 (if available)

Paralogs for ST6GALNAC2 Gene

Paralogs for ST6GALNAC2 Gene

Selected SIMAP similar genes for ST6GALNAC2 Gene using alignment to 5 proteins: Pseudogenes for ST6GALNAC2 Gene

genes like me logo Genes that share paralogs with ST6GALNAC2: view

Variants for ST6GALNAC2 Gene

Sequence variations from dbSNP and Humsavar for ST6GALNAC2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1053392 -- 76,566,087(+) CAAAG(C/G)GCTCA utr-variant-3-prime
rs1867561 -- 76,585,943(+) CGCCT(C/G)CCCGC utr-variant-5-prime
rs2120885 -- 76,567,190(-) CAGGC(C/T)TCCTT intron-variant
rs2120886 -- 76,567,093(-) CATAC(C/T)GGGCC intron-variant
rs2166212 -- 76,566,865(-) TCCAC(A/G)ACTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST6GALNAC2 Gene

Variant ID Type Subtype PubMed ID
nsv828107 CNV Loss 20364138
esv28008 CNV Loss 19812545

Relevant External Links for ST6GALNAC2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST6GALNAC2 Gene

Disorders for ST6GALNAC2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ST6GALNAC2 Gene including...

Search for ST6GALNAC2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ST6GALNAC2 Gene

Relevant External Links for ST6GALNAC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ST6GALNAC2: view

No data available for UniProtKB/Swiss-Prot for ST6GALNAC2 Gene

Publications for ST6GALNAC2 Gene

  1. Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells. (PMID: 10742600) Samyn-Petit B. … Harduin-Lepers A. (Biochim. Biophys. Acta 2000) 3 4 23
  2. Interaction between variants of two glycosyltransferase genes in IgA nephropathy. (PMID: 19357720) Zhu L. … Wang H. (Kidney Int. 2009) 3 4 48
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Identification and functional characterization of a human GalNAc [alpha]2,6-sialyltransferase with altered expression in breast cancer. (PMID: 11984005) Sotiropoulou G. … Sager R. (Mol. Med. 2002) 2 23
  5. Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy. (PMID: 17480010) Li G.S. … Wang H.Y. (Hum. Mutat. 2007) 3 48

Products for ST6GALNAC2 Gene

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Sources for ST6GALNAC2 Gene

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