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Aliases for ST6GALNAC2 Gene

Aliases for ST6GALNAC2 Gene

  • ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 2
  • ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 2 3 5
  • ST6 GalNAc Alpha-2,6-Sialyltransferase 2 2 3
  • GalNAc Alpha-2,6-Sialyltransferase II 3 4
  • Sialyltransferase-Like 1 2 3
  • Sialyltransferase 7B 3 4
  • ST6GalNAc II 3 4
  • ST6GalNAcII 3 4
  • SIAT7-B 3 4
  • SIAT7B 3 4
  • SIATL1 3 4
  • STHM 3 4
  • Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) B 3
  • Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) 2
  • (Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase 3
  • Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide B 3
  • (Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide B 3
  • ST6GALNAC2, Alpha-2,6-Sialyltransferase 2 3
  • EC 2.4.99.- 4
  • ST6GalNAII 3
  • SAITL1 3
  • SIAT7 3

External Ids for ST6GALNAC2 Gene

Previous HGNC Symbols for ST6GALNAC2 Gene

  • SIAT7
  • SIAT7B
  • SIATL1

Previous GeneCards Identifiers for ST6GALNAC2 Gene

  • GC17M072074
  • GC17M074561
  • GC17M069989

Summaries for ST6GALNAC2 Gene

Entrez Gene Summary for ST6GALNAC2 Gene

  • ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion, and protein targeting (Samyn-Petit et al., 2000 [PubMed 10742600]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ST6GALNAC2 Gene

ST6GALNAC2 (ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Synthesis of substrates in N-glycan biosythesis. GO annotations related to this gene include sialyltransferase activity. An important paralog of this gene is ST3GAL4.

Gene Wiki entry for ST6GALNAC2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST6GALNAC2 Gene

Genomics for ST6GALNAC2 Gene

Regulatory Elements for ST6GALNAC2 Gene

Enhancers for ST6GALNAC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ST6GALNAC2 on UCSC Golden Path with GeneCards custom track

Promoters for ST6GALNAC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ST6GALNAC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ST6GALNAC2 Gene

Chromosome:
17
Start:
76,563,710 bp from pter
End:
76,586,956 bp from pter
Size:
23,247 bases
Orientation:
Minus strand

Genomic View for ST6GALNAC2 Gene

Genes around ST6GALNAC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST6GALNAC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST6GALNAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST6GALNAC2 Gene

Proteins for ST6GALNAC2 Gene

  • Protein details for ST6GALNAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJ37-SIA7B_HUMAN
    Recommended name:
    Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
    Protein Accession:
    Q9UJ37
    Secondary Accessions:
    • Q12971

    Protein attributes for ST6GALNAC2 Gene

    Size:
    374 amino acids
    Molecular mass:
    41939 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Aberrant O-galactosylation of IgA1 molecules plays a role in the development and progression of IgA nephropathy (IgAN). Genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation, disease predisposition, and disease severity, and may contribute to the polygenic nature of IgAN.

neXtProt entry for ST6GALNAC2 Gene

Proteomics data for ST6GALNAC2 Gene at MOPED

Post-translational modifications for ST6GALNAC2 Gene

  • Glycosylation at Asn 85, Asn 130, and Asn 161
  • Modification sites at PhosphoSitePlus

Other Protein References for ST6GALNAC2 Gene

Antibody Products

No data available for DME Specific Peptides for ST6GALNAC2 Gene

Domains & Families for ST6GALNAC2 Gene

Gene Families for ST6GALNAC2 Gene

Protein Domains for ST6GALNAC2 Gene

Suggested Antigen Peptide Sequences for ST6GALNAC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJ37

UniProtKB/Swiss-Prot:

SIA7B_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST6GALNAC2: view

Function for ST6GALNAC2 Gene

Molecular function for ST6GALNAC2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
CMP-N-acetylneuraminate + glycano-beta-D-galactosyl-1,3-(N-acetyl-D-galactosaminyl)-glycoprotein = CMP + glycano-beta-D-galactosyl-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein.

Enzyme Numbers (IUBMB) for ST6GALNAC2 Gene

Gene Ontology (GO) - Molecular Function for ST6GALNAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity TAS --
genes like me logo Genes that share ontologies with ST6GALNAC2: view
genes like me logo Genes that share phenotypes with ST6GALNAC2: view

Animal Models for ST6GALNAC2 Gene

MGI Knock Outs for ST6GALNAC2:

Animal Model Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ST6GALNAC2 Gene

Localization for ST6GALNAC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST6GALNAC2 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST6GALNAC2 Gene COMPARTMENTS Subcellular localization image for ST6GALNAC2 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ST6GALNAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0030173 integral component of Golgi membrane IEA --
genes like me logo Genes that share ontologies with ST6GALNAC2: view

Pathways & Interactions for ST6GALNAC2 Gene

genes like me logo Genes that share pathways with ST6GALNAC2: view

UniProtKB/Swiss-Prot Q9UJ37-SIA7B_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for ST6GALNAC2 Gene

Gene Ontology (GO) - Biological Process for ST6GALNAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001574 ganglioside biosynthetic process IBA --
GO:0006486 protein glycosylation IEA --
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
genes like me logo Genes that share ontologies with ST6GALNAC2: view

No data available for SIGNOR curated interactions for ST6GALNAC2 Gene

Drugs & Compounds for ST6GALNAC2 Gene

(2) Additional Compounds for ST6GALNAC2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytidine monophosphate
  • 5'-CMP
  • 5-Cytidylate
  • 5-Cytidylic acid
  • CMP
  • Cytidine 5'-monophosphate
63-37-6
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-Acetylneuraminate
  • CMP-N-Acylneuraminate
  • CMP-NeuNAc
  • Cytidine 5'-monophosphate N-acetylneuraminic acid
  • Cytidine Monophosphate N-Acetylneuraminate
22-12-8
genes like me logo Genes that share compounds with ST6GALNAC2: view

Transcripts for ST6GALNAC2 Gene

Unigene Clusters for ST6GALNAC2 Gene

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
SP1: - - - -
SP2: -
SP3: - -
SP4:
SP5: -
SP6:

Relevant External Links for ST6GALNAC2 Gene

GeneLoc Exon Structure for
ST6GALNAC2
ECgene alternative splicing isoforms for
ST6GALNAC2

Expression for ST6GALNAC2 Gene

mRNA expression in normal human tissues for ST6GALNAC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST6GALNAC2 Gene

This gene is overexpressed in Nerve - Tibial (x7.4), Testis (x6.1), and Whole Blood (x5.2).

Protein differential expression in normal tissues from HIPED for ST6GALNAC2 Gene

This gene is overexpressed in Synovial fluid (55.7) and Placenta (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ST6GALNAC2 Gene



SOURCE GeneReport for Unigene cluster for ST6GALNAC2 Gene Hs.592105

mRNA Expression by UniProt/SwissProt for ST6GALNAC2 Gene

Q9UJ37-SIA7B_HUMAN
Tissue specificity: Expressed in skeletal muscle, heart, kidney, placenta, lung and leukocytes.
genes like me logo Genes that share expression patterns with ST6GALNAC2: view

Protein tissue co-expression partners for ST6GALNAC2 Gene

Primer Products

Orthologs for ST6GALNAC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST6GALNAC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ST6GALNAC2 35
  • 83.82 (n)
  • 81.5 (a)
ST6GALNAC2 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ST6GALNAC2 35
  • 85.83 (n)
  • 82.35 (a)
ST6GALNAC2 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St6galnac2 35
  • 79.36 (n)
  • 75.07 (a)
St6galnac2 16
St6galnac2 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ST6GALNAC2 35
  • 97.95 (n)
  • 96.79 (a)
ST6GALNAC2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia St6galnac2 35
  • 79.09 (n)
  • 75.34 (a)
oppossum
(Monodelphis domestica)
Mammalia ST6GALNAC2 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ST6GALNAC2 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves ST6GALNAC2 35
  • 63.54 (n)
  • 61.39 (a)
ST6GALNAC2 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST6GALNAC2 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia siat7b 35
st6galnac2 35
  • 62.66 (n)
  • 62.66 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15681 35
zebrafish
(Danio rerio)
Actinopterygii st6galnac2 35
  • 59.31 (n)
  • 57.3 (a)
ST6GALNAC2 36
  • 49 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11887 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4378 36
  • 22 (a)
OneToMany
Species with no ortholog for ST6GALNAC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST6GALNAC2 Gene

ENSEMBL:
Gene Tree for ST6GALNAC2 (if available)
TreeFam:
Gene Tree for ST6GALNAC2 (if available)

Paralogs for ST6GALNAC2 Gene

Paralogs for ST6GALNAC2 Gene

(2) SIMAP similar genes for ST6GALNAC2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ST6GALNAC2 Gene

genes like me logo Genes that share paralogs with ST6GALNAC2: view

Variants for ST6GALNAC2 Gene

Sequence variations from dbSNP and Humsavar for ST6GALNAC2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1053392 -- 76,566,087(+) CAAAG(C/G)GCTCA utr-variant-3-prime
rs2120885 -- 76,567,190(-) CAGGC(C/T)TCCTT intron-variant, downstream-variant-500B
rs2120886 -- 76,567,093(-) CATAC(C/T)GGGCC intron-variant, downstream-variant-500B
rs1867561 -- 76,585,943(+) CGCCT(C/G)CCCGC nc-transcript-variant, utr-variant-5-prime
rs2166212 -- 76,566,865(-) TCCAC(A/G)ACTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST6GALNAC2 Gene

Variant ID Type Subtype PubMed ID
nsv828107 CNV Loss 20364138
esv28008 CNV Loss 19812545

Variation tolerance for ST6GALNAC2 Gene

Residual Variation Intolerance Score: 60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.81% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ST6GALNAC2 Gene

Disorders for ST6GALNAC2 Gene

Relevant External Links for ST6GALNAC2

Genetic Association Database (GAD)
ST6GALNAC2
Human Genome Epidemiology (HuGE) Navigator
ST6GALNAC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ST6GALNAC2

No disorders were found for ST6GALNAC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST6GALNAC2 Gene

Publications for ST6GALNAC2 Gene

  1. Interaction between variants of two glycosyltransferase genes in IgA nephropathy. (PMID: 19357720) Zhu L. … Wang H. (Kidney Int. 2009) 3 4 48 67
  2. Identification and functional characterization of a human GalNAc [alpha]2,6-sialyltransferase with altered expression in breast cancer. (PMID: 11984005) Sotiropoulou G. … Sager R. (Mol. Med. 2002) 2 23
  3. Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells. (PMID: 10742600) Samyn-Petit B. … Harduin-Lepers A. (Biochim. Biophys. Acta 2000) 3 23
  4. Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes. (PMID: 24398680) Suzuki H. … Novak J. (J. Biol. Chem. 2014) 3
  5. An in vivo functional screen identifies ST6GalNAc2 sialyltransferase as a breast cancer metastasis suppressor. (PMID: 24520024) Murugaesu N. … Isacke C.M. (Cancer Discov 2014) 3

Products for ST6GALNAC2 Gene

Sources for ST6GALNAC2 Gene

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