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ST6GALNAC2 Gene

protein-coding   GIFtS: 60
GCID: GC17M074561

ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide...

(Previous names: sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl...)
(Previous symbols: SIAT7, SIAT7B, SIATL1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
ST6
(Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide
Alpha-2,6-Sialyltransferase 21 2
     SAITL12 5
SIAT7B1 2 3 5     Sialyltransferase 7
((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl
Galactosaminide Alpha-2,6-Sialyltransferase)1
SIATL11 2 3     (Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl
Galactosaminide Alpha-2,6-Sialyltransferase2
SIAT71 2     (Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl
Galactosaminide B2
Sialyltransferase-Like 11 2     ST6GalNAII2
GalNAc Alpha-2,6-Sialyltransferase II2 3     Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 22
Sialyltransferase 7B2 3     Sialyltransferase 7
((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl
Galactosaminide Alpha-2,6-Sialyltransferase) B2
SIAT7-B2 3     Sialyltransferase 7
((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl
Galactosaminide B2
ST6GalNAcII2 3     EC 2.4.99.-3
STHM2 3     SThM3
ST6GalNAc II2 3     

External Ids:    HGNC: 108671   Entrez Gene: 106102   Ensembl: ENSG000000707317   OMIM: 6101375   UniProtKB: Q9UJ373   
ORGUL members:         

Export aliases for ST6GALNAC2 gene to outside databases

Previous GC identifers: GC17M072074 GC17M069989


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ST6GALNAC2 Gene:
ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of
glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate
interactions, bacterial adhesion, and protein targeting (Samyn-Petit et al., 2000 (PubMed 10742600)).(supplied by
OMIM, Mar 2008)

GeneCards Summary for ST6GALNAC2 Gene:
ST6GALNAC2 (ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2) is a protein-coding gene. Diseases associated with ST6GALNAC2 include iga glomerulonephritis, and glomerulonephritis. GO annotations related to this gene include sialyltransferase activity. An important paralog of this gene is ST3GAL3.

Gene Wiki entry for ST6GALNAC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ST6GALNAC2 gene promoter:
         Egr-3   GATA-3   p53   Pax-5   Evi-1   Egr-2   FOXO4   Pax-4a   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidST6GALNAC2 promoter sequence
   Search Chromatin IP Primers for ST6GALNAC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST6GALNAC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

ST6GALNAC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST6GALNAC2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M074561:  view genomic region     (about GC identifiers)

Start:
74,559,792 bp from pter      End:
74,583,038 bp from pter
Size:
23,247 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SIA7B_HUMAN, Q9UJ37 (See protein sequence)
Recommended Name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2  
Size: 374 amino acids; 41939 Da
Miscellaneous: Aberrant O-galactosylation of IgA1 molecules plays a role in the development and progression of IgA
nephropathy (IgAN). Genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation,
disease predisposition, and disease severity, and may contribute to the polygenic nature of IgAN
Secondary accessions: Q12971

Explore the universe of human proteins at neXtProt for ST6GALNAC2: NX_Q9UJ37

Explore proteomics data for ST6GALNAC2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn85, Asn130, Asn161

  • See ST6GALNAC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006447.2  
    ENSEMBL proteins: 
     ENSP00000225276   ENSP00000464915   ENSP00000466560   ENSP00000465778   ENSP00000466513  
    Reactome Protein details: Q9UJ37

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ST3G: Sialyltransferases

    2 InterPro protein domains:
     IPR001675 Glyco_trans_29
     IPR012163 Sialyl_trans

    Graphical View of Domain Structure for InterPro Entry Q9UJ37

    ProtoNet protein and cluster: Q9UJ37

    1 Blocks protein domain: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIA7B_HUMAN, Q9UJ37
    Similarity: Belongs to the glycosyltransferase 29 family


    ST6GALNAC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIA7B_HUMAN, Q9UJ37
    Catalytic activity: CMP-N-acetylneuraminate +
    glycano-beta-D-galactosyl-1,3-(N-acetyl-D-galactosaminyl)-glycoprotein = CMP +
    glycano-beta-D-galactosyl-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein

         Enzyme Number (IUBMB): EC 2.4.99.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008373sialyltransferase activity IEA--
         
    ST6GALNAC2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ST6GALNAC2:
     Increased cell death HMECs cel  Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for St6galnac2 (no phenotypes)

    ST6GALNAC2 for phenotypes           About GeneDecksing

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIA7B_HUMAN, Q9UJ37: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular2
    endoplasmic reticulum1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus ----
    GO:0016021integral component of membrane ----
    GO:0030173integral component of Golgi membrane IEA--

    ST6GALNAC2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ST6GALNAC2 About    
    See pathways by source

    SuperPathContained pathways About
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.47
    Termination of O-glycan biosynthesis0.38
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for ST6GALNAC2
        Sialic acid metabolism
    Termination of O-glycan biosynthesis


    UniProtKB/Swiss-Prot: SIA7B_HUMAN, Q9UJ37
    Pathway: Protein modification; protein glycosylation


    ST6GALNAC2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ST6GALNAC2
    Interactions:

        Search GeneGlobe Interaction Network for ST6GALNAC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for ST6GALNAC2 (Q9UJ372, 3 ENSP000002252764) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840222, 3MINT-61718 I2D: score=3 
    MUC1ENSP000003389834STRING: ENSP00000338983
    MUC2ENSP000004151834STRING: ENSP00000415183
    MUC20ENSP000003967744STRING: ENSP00000396774
    MUC12ENSP000003687554STRING: ENSP00000368755
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation ----
    GO:0016266O-glycan processing TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    ST6GALNAC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ST6GALNAC2 (SIA7B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ST6GALNAC2 gene: 
    NM_006456.2  

    Unigene Cluster for ST6GALNAC2:

    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
    Hs.592105  [show with all ESTs]
    Unigene Representative Sequence: NM_006456
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589997 ENST00000225276(uc002jsg.4) ENST00000585390 ENST00000588920
    ENST00000592979 ENST00000588120 ENST00000586520 ENST00000588005 ENST00000585736
    ENST00000592508
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    hsa-miR-623 hsa-miR-298 hsa-miR-2116
    SwitchGear 3'UTR luciferase reporter plasmidST6GALNAC2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AJ251053.1 AK225943.1 BT019972.1 U14550.1 

    11 DOTS entries:

    DT.75145294  DT.99976584  DT.120982351  DT.100828311  DT.100021745  DT.100796373  DT.92443381  DT.95216805 
    DT.100796378  DT.91984147  DT.95216803 

    Selected AceView cDNA sequences (see all 159):

    AA456371 AI184687 CA489243 AI922174 BQ424322 BQ773939 CA392645 BQ882535 
    AU141538 BM705458 AW873476 CB410770 AI375909 CB410651 BC040455 CA419632 
    AA497128 BM719305 AA497051 AA455905 AI090258 BE563164 AI125788 NM_006456 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
    SP1:                    -     -                             -                             -                                 
    SP2:                                                                                      -                                 
    SP3:                    -     -                                                                                             
    SP4:                                                                                                                        
    SP5:                          -                                                                                             


    ECgene alternative splicing isoforms for ST6GALNAC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ST6GALNAC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGATGACTC
    ST6GALNAC2 Expression
    About this image


    ST6GALNAC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Definitive endoderm-like cells
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced SK11 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced SM30 cells
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Adipose (Muscoskeletal System)
             HyStem+BMP4-induced SM30 cells
    ST6GALNAC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ST6GALNAC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592105

    UniProtKB/Swiss-Prot: SIA7B_HUMAN, Q9UJ37
    Tissue specificity: Expressed in skeletal muscle, heart, kidney, placenta, lung and leukocytes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ST6GALNAC2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St6galnac21 , 5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more1, 5 79.36(n)1
    75.07(a)1
      11 (81.49 cM)5
    204461  NM_009180.31  NP_033206.21 
     1166753035 
    chicken
    (Gallus gallus)
    Aves ST6GALNAC21 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more 63.54(n)
    61.39(a)
      396159  NM_205233.1  NP_990564.1 
    lizard
    (Anolis carolinensis)
    Reptilia ST6GALNAC26
    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl...
    54(a)
    1 ↔ 1
    2(111847203-111891744)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.156812 Xenopus laevis transcribed sequence with moderate similarity more 76.28(n)    BJ624886.1 
    zebrafish
    (Danio rerio)
    Actinopterygii st6galnac21 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more 59.31(n)
    57.3(a)
      100001225  NM_001171222.1  NP_001164693.1 


    ENSEMBL Gene Tree for ST6GALNAC2 (if available)
    TreeFam Gene Tree for ST6GALNAC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ST6GALNAC2 gene
    ST3GAL32  ST6GALNAC12  ST3GAL62  ST3GAL12  ST3GAL42  ST3GAL22  ST3GAL52  
    2 SIMAP similar genes for ST6GALNAC2 using alignment to 5 protein entries:     SIA7B_HUMAN (see all proteins):
    ST3GAL1    ST6GALNAC1

    ST6GALNAC2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ST6GALNAC2
    PGOHUM00000240117


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ST6GALNAC2 (see all 627)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22419191,2
    C,F,A,H--74561950(-) GAAAAT/CGGACT 1 -- ut3120Minor allele frequency- C:0.08EA NS NA WA 3848
    rs1835718001,2
    --74562085(+) CTGTTA/GGCAAG 1 -- ut310--------
    rs1868726271,2
    --74562103(+) GAAGAC/TTGAAA 1 -- ut310--------
    rs1910699461,2
    --74562126(+) TTTTGA/GCCACT 1 -- ut310--------
    rs1446988751,2
    --74562128(+) TTGGCC/TACTTG 1 -- ut310--------
    rs1831983581,2
    C--74562142(+) GGATCA/TGGGCC 1 -- ut310--------
    rs1482280821,2
    C--74562146(+) CAGGGC/TCGCAA 1 -- ut310--------
    rs3767613361,2
    C--74562147(+) AGGGCC/TGCAAC 1 -- ut310--------
    rs10533921,2
    C,F--74562169(+) CAAAGG/CGCTCA 1 -- ut314Minor allele frequency- C:0.05MN WA CSA 308
    rs2003522661,2
    --74562186(+) TGGGGG/TCAGCG 2 * C --0--------

    HapMap Linkage Disequilibrium report for ST6GALNAC2 (74559792 - 74583038 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ST6GALNAC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv28008CNV Loss19812545
    nsv828107CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ST6GALNAC2
    DNA2.0 Custom Variant and Variant Library Synthesis for ST6GALNAC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610137    OMIM disorders: --

    4 diseases for ST6GALNAC2:    
    About MalaCards
    iga glomerulonephritis    glomerulonephritis    choroiditis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for ST6GALNAC2:
    IgA glomerulonephritis

    ST6GALNAC2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ST6GALNAC2
    Human Genome Epidemiology (HuGE) Navigator: ST6GALNAC2 (2 documents)

    Export disorders for ST6GALNAC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ST6GALNAC2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with ST6GALNAC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction between variants of two glycosyltransferase genes in IgA nephropathy. (PubMed id 19357720)1, 2, 4 Zhu L.... Wang H. (Kidney Int. 2009)
    2. Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells. (PubMed id 10742600)1, 2, 9 Samyn-Petit B....Harduin-Lepers A. (Biochim. Biophys. Acta 2000)
    3. Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy. (PubMed id 17480010)1, 4 Li G.S....Wang H.Y. (Hum. Mutat. 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Identification and functional characterization of a human GalNAc [alpha]2,6-sialyltransferase with altered expression in breast cancer. (PubMed id 11984005)3, 9 Sotiropoulou G....Sager R. (Mol. Med. 2002)
    6. Competition between core-2 GlcNAc-transferase and ST6GalNAc-transferase regulates the synthesis of the leukocyte selectin ligand on human P-selectin glycoprotein ligand-1. (PubMed id 23548905)1 Lo C.Y....Neelamegham S. (J. Biol. Chem. 2013)
    7. Activity of alpha2,6-sialyltransferase and its gene expression in peripheral B lymphocytes in patients with IgA nephropathy. (PubMed id 19170967)1 Ding J.X....Wang H.Y. (Scand. J. Immunol. 2009)
    8. Identification and characterization of CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase in IgA1-producing cells. (PubMed id 17418236)1 Raska M....Novak J. (J. Mol. Biol. 2007)
    9. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10610 HGNC: 10867 AceView: SIAT7B Ensembl:ENSG00000070731 euGenes: HUgn10610
    ECgene: ST6GALNAC2 H-InvDB: ST6GALNAC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ST6GALNAC2 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST6GALNAC2
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_631

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ST6GALNAC2 gene:
    Search GeneIP for patents involving ST6GALNAC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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