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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ST6GALNAC2 Gene

protein-coding   GIFtS: 60
GCID: GC17M074561

ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide...

(Previous names: sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl...)
(Previous symbols: SIAT7, SIAT7B, SIATL1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ST6
(Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide
Alpha-2,6-Sialyltransferase 21 2
     Sialyltransferase 7
((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl
Galactosaminide Alpha-2,6-Sialyltransferase)1
SIAT7B1 2 3     (Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl
Galactosaminide Alpha-2,6-Sialyltransferase2
SIATL11 2 3     (Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl
Galactosaminide B2
SIAT71 2     SAITL12
Sialyltransferase-Like 11 2     ST6GalNAII2
GalNAc Alpha-2,6-Sialyltransferase II2 3     Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 22
Sialyltransferase 7B2 3     Sialyltransferase 7
((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl
Galactosaminide Alpha-2,6-Sialyltransferase) B2
SIAT7-B2 3     Sialyltransferase 7
((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl
Galactosaminide B2
ST6GalNAcII2 3     EC 2.4.99.-3
STHM2 3     SThM3
ST6GalNAc II2 3     

External Ids:    HGNC: 108671   Entrez Gene: 106102   Ensembl: ENSG000000707317   OMIM: 6101375   UniProtKB: Q9UJ373   

Export aliases for ST6GALNAC2 gene to outside databases

Previous GC identifers: GC17M072074 GC17M069989


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ST6GALNAC2 Gene:
ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of
glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate
interactions, bacterial adhesion, and protein targeting (Samyn-Petit et al., 2000 (PubMed 10742600)).(supplied by
OMIM, Mar 2008)

GeneCards Summary for ST6GALNAC2 Gene: 
ST6GALNAC2 (ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2) is a protein-coding gene. Diseases associated with ST6GALNAC2 include iga glomerulonephritis, and glomerulonephritis, and among its related super-pathways are Mucin type O-Glycan biosynthesis and Post-translational protein modification. GO annotations related to this gene include sialyltransferase activity. An important paralog of this gene is ST3GAL3.

Gene Wiki entry for ST6GALNAC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ST6GALNAC2 gene promoter:
         Egr-3   GATA-3   p53   Pax-5   Evi-1   Egr-2   FOXO4   Pax-4a   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidST6GALNAC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ST6GALNAC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST6GALNAC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

ST6GALNAC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST6GALNAC2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M074561:  view genomic region     (about GC identifiers)

Start:
74,559,792 bp from pter      End:
74,583,038 bp from pter
Size:
23,247 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SIA7B_HUMAN, Q9UJ37 (See protein sequence)
Recommended Name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2  
Size: 374 amino acids; 41939 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
Miscellaneous: Aberrant O-galactosylation of IgA1 molecules plays a role in the development and progression of IgA
nephropathy (IgAN). Genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation,
disease predisposition, and disease severity, and may contribute to the polygenic nature of IgAN
Secondary accessions: Q12971

Explore the universe of human proteins at neXtProt for ST6GALNAC2: NX_Q9UJ37

Explore proteomics data for ST6GALNAC2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UJ37

  • ST6GALNAC2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ST6GALNAC2 Protein Expression
    REFSEQ proteins: NP_006447.2  
    ENSEMBL proteins: 
     ENSP00000225276   ENSP00000464915   ENSP00000466560   ENSP00000465778   ENSP00000466513  
    Reactome Protein details: Q9UJ37
    Human Recombinant Protein Products for ST6GALNAC2: 
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    Sino Biological Cell Lysate for ST6GALNAC2 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus ----
    GO:0016021integral to membrane ----
    GO:0030173integral to Golgi membrane IEA--

    ST6GALNAC2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ST3G: Sialyltransferases

    2 InterPro protein domains:
     IPR001675 Glyco_trans_29
     IPR012163 Sialyl_trans

    Graphical View of Domain Structure for InterPro Entry Q9UJ37

    ProtoNet protein and cluster: Q9UJ37

    1 Blocks protein domain: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIA7B_HUMAN, Q9UJ37
    Similarity: Belongs to the glycosyltransferase 29 family


    ST6GALNAC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIA7B_HUMAN, Q9UJ37
    Catalytic activity: CMP-N-acetylneuraminate +
    glycano-beta-D-galactosyl-1,3-(N-acetyl-D-galactosaminyl)-glycoprotein = CMP +
    glycano-beta-D-galactosyl-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein

         Enzyme Number (IUBMB): EC 2.4.99.-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008373sialyltransferase activity IEA--
         
    ST6GALNAC2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ST6GALNAC2:
     Increased cell death HMECs cel  Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for St6galnac2 (no phenotypes)

    ST6GALNAC2 for phenotypes           About GeneDecksing

    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ST6GALNAC2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.44
    Termination of O-glycan biosynthesis0.41
    2Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4        Reactome Pathways for ST6GALNAC2
        O-linked glycosylation of mucins
    Metabolism of proteins
    Post-translational protein modification
    Termination of O-glycan biosynthesis


    UniProtKB/Swiss-Prot: SIA7B_HUMAN, Q9UJ37
    Pathway: Protein modification; protein glycosylation


    ST6GALNAC2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ST6GALNAC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/15 Interacting proteins for ST6GALNAC2 (Q9UJ372, 3 ENSP000002252764) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840222, 3MINT-61718 I2D: score=3 
    MUC1ENSP000003389834STRING: ENSP00000338983
    MUC2ENSP000004151834STRING: ENSP00000415183
    MUC20ENSP000003967744STRING: ENSP00000396774
    MUC12ENSP000003687554STRING: ENSP00000368755
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation ----
    GO:0016266O-glycan processing TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    ST6GALNAC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ST6GALNAC2 (SIA7B)

    Search CenterWatch for drugs/clinical trials and news about ST6GALNAC2 / SIA7B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ST6GALNAC2 gene: 
    NM_006456.2  

    Unigene Cluster for ST6GALNAC2:

    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
    Hs.592105  [show with all ESTs]
    Unigene Representative Sequence: NM_006456
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589997 ENST00000225276(uc002jsg.4) ENST00000585390 ENST00000588920
    ENST00000592979 ENST00000588120 ENST00000586520 ENST00000588005 ENST00000585736
    ENST00000592508
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    Additional mRNA sequence: 

    AJ251053.1 AK225943.1 BT019972.1 U14550.1 

    11 DOTS entries:

    DT.75145294  DT.99976584  DT.120982351  DT.100828311  DT.100021745  DT.100796373  DT.92443381  DT.95216805 
    DT.100796378  DT.91984147  DT.95216803 

    24/159 AceView cDNA sequences (see all 159):

    BM705458 CB410770 BQ773939 CA419632 AU141538 CB410651 AA497128 BQ424322 
    CA392645 AA456371 AI184687 AI375909 BC040455 CA489243 AW873476 BQ882535 
    AI922174 AA824310 NM_006456 BI850217 AI090258 AI683334 AI458633 AI628040 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
    SP1:                    -     -                             -                             -                                 
    SP2:                                                                                      -                                 
    SP3:                    -     -                                                                                             
    SP4:                                                                                                                        
    SP5:                          -                                                                                             


    ECgene alternative splicing isoforms for ST6GALNAC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ST6GALNAC2 expression in normal human tissues (normalized intensities)      ST6GALNAC2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGATGACTC
    ST6GALNAC2 Expression
    About this image


    ST6GALNAC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Epidermis (Integumentary System)    fully expand to see all 5 entries
             Human EpiDermal Melanocytes-medium (HEM-m)   
     
     Melanocytes (Integumentary System)    fully expand to see all 3 entries
             Human EpiDermal Melanocytes-medium (HEM-m)   
     
     Epithelium (Uncategorized)    fully expand to see all 3 entries
             Human Bronchial Epithelial Cells (HBEpiC)   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Olfactory Bulb   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Endoderm progenitor-like cells ( Generation and expansion of endodermal progenitor...

    See ST6GALNAC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ST6GALNAC2

    SOURCE GeneReport for Unigene cluster: Hs.592105

    UniProtKB/Swiss-Prot: SIA7B_HUMAN, Q9UJ37
    Tissue specificity: Expressed in skeletal muscle, heart, kidney, placenta, lung and leukocytes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ST6GALNAC2 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St6galnac21 , 5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more1, 5 79.36(n)1
    75.07(a)1
      11 (81.49 cM)5
    204461  NM_009180.31  NP_033206.21 
     1166753035 
    chicken
    (Gallus gallus)
    Aves ST6GALNAC21 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more 63.45(n)
    61.39(a)
      396159  NM_205233.1  NP_990564.1 
    lizard
    (Anolis carolinensis)
    Reptilia ST6GALNAC26
    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl...
    53(a)
    1 ↔ 1
    2(111847203-111891744)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.156812 Xenopus laevis transcribed sequence with moderate similarity more 76.28(n)    BJ624886.1 
    zebrafish
    (Danio rerio)
    Actinopterygii st6galnac21 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more 59.26(n)
    57.71(a)
      100001225  NM_001171222.1  NP_001164693.1 


    ENSEMBL Gene Tree for ST6GALNAC2 (if available)
    TreeFam Gene Tree for ST6GALNAC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ST6GALNAC2 gene
    ST3GAL32  ST6GALNAC12  ST3GAL62  ST3GAL12  ST3GAL42  ST3GAL22  ST3GAL52  
    2 SIMAP similar genes for ST6GALNAC2 using alignment to 5 protein entries:     SIA7B_HUMAN (see all proteins):
    ST3GAL1    ST6GALNAC1

    ST6GALNAC2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ST6GALNAC2
    PGOHUM00000240117


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/627 SNPs in ST6GALNAC2 are shown (see all 627)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22419191,2
    C,F,A,H--74561950(-) GAAAAT/CGGACT 1 -- ut3120Minor allele frequency- C:0.08EA NS NA WA 3848
    rs1835718001,2
    --74562085(+) CTGTTA/GGCAAG 1 -- ut310--------
    rs1868726271,2
    --74562103(+) GAAGAC/TTGAAA 1 -- ut310--------
    rs1910699461,2
    --74562126(+) TTTTGA/GCCACT 1 -- ut310--------
    rs1446988751,2
    --74562128(+) TTGGCC/TACTTG 1 -- ut310--------
    rs1831983581,2
    C--74562142(+) GGATCA/TGGGCC 1 -- ut310--------
    rs1482280821,2
    C--74562146(+) CAGGGC/TCGCAA 1 -- ut310--------
    rs3767613361,2
    C--74562147(+) AGGGCC/TGCAAC 1 -- ut310--------
    rs10533921,2
    C,F--74562169(+) CAAAGG/CGCTCA 1 -- ut314Minor allele frequency- C:0.05MN WA CSA 308
    rs2003522661,2
    --74562186(+) TGGGGG/TCAGCG 2 * C --0--------

    HapMap Linkage Disequilibrium report for ST6GALNAC2 (74559792 - 74583038 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ST6GALNAC2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv28008CNV Loss19812545
    nsv828107CNV Loss20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610137    OMIM disorders: --

    3 diseases for ST6GALNAC2:    About MalaCards
    iga glomerulonephritis    glomerulonephritis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for ST6GALNAC2:
    IgA glomerulonephritis

    ST6GALNAC2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ST6GALNAC2
    Human Genome Epidemiology (HuGE) Navigator: ST6GALNAC2 (2 documents)

    Export disorders for ST6GALNAC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ST6GALNAC2 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with ST6GALNAC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction between variants of two glycosyltransferase genes in IgA nephropathy. (PubMed id 19357720)1, 2, 4 Zhu L.... Wang H. (2009)
    2. Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells. (PubMed id 10742600)1, 2, 9 Samyn-Petit B....Harduin-Lepers A. (2000)
    3. Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy. (PubMed id 17480010)1, 4 Li G.S....Wang H.Y. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Identification and functional characterization of a human GalNAc [alpha]2,6-sialyltransferase with altered expression in breast cancer. (PubMed id 11984005)3, 9 Sotiropoulou G....Sager R. (2002)
    6. Competition between core-2 GlcNAc-transferase and ST6G alNAc-transferase regulates the synthesis of the leukocyte selectin ligand on hu man P-selectin glycoprotein ligand-1. (PubMed id 23548905)1 Lo C.Y....Neelamegham S. (2013)
    7. Activity of alpha2,6-sialyltransferase and its gene expression in peripheral B lymphocytes in patients with IgA nephropathy. (PubMed id 19170967)1 Ding J.X....Wang H.Y. (2009)
    8. Identification and characterization of CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase in IgA1-producing cells. (PubMed id 17418236)1 Raska M....Novak J. (2007)
    9. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10610 HGNC: 10867 AceView: SIAT7B Ensembl:ENSG00000070731 euGenes: HUgn10610
    ECgene: ST6GALNAC2 H-InvDB: ST6GALNAC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ST6GALNAC2 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST6GALNAC2
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_631

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ST6GALNAC2 gene:
    Search GeneIP for patents involving ST6GALNAC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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