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Aliases for ST6GALNAC2 Gene

Aliases for ST6GALNAC2 Gene

  • ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 2 3 5
  • ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 2 3
  • ST6 GalNAc Alpha-2,6-Sialyltransferase 2 2 3
  • GalNAc Alpha-2,6-Sialyltransferase II 3 4
  • Sialyltransferase-Like 1 2 3
  • Sialyltransferase 7B 3 4
  • ST6GalNAc II 3 4
  • ST6GalNAcII 3 4
  • SIAT7-B 3 4
  • SIAT7B 3 4
  • SIATL1 3 4
  • STHM 3 4
  • Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) B 3
  • Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) 2
  • (Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase 3
  • Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide B 3
  • (Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide B 3
  • Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 3
  • ST6GALNAC2, Alpha-2,6-Sialyltransferase 2 3
  • EC 2.4.99.- 4
  • ST6GalNAII 3
  • SAITL1 3
  • SIAT7 3

External Ids for ST6GALNAC2 Gene

Previous HGNC Symbols for ST6GALNAC2 Gene

  • SIAT7
  • SIAT7B
  • SIATL1

Previous GeneCards Identifiers for ST6GALNAC2 Gene

  • GC17M072074
  • GC17M074561
  • GC17M069989

Summaries for ST6GALNAC2 Gene

Entrez Gene Summary for ST6GALNAC2 Gene

  • ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion, and protein targeting (Samyn-Petit et al., 2000 [PubMed 10742600]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ST6GALNAC2 Gene

ST6GALNAC2 (ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2) is a Protein Coding gene. Diseases associated with ST6GALNAC2 include Colorectal Cancer. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity. An important paralog of this gene is ST6GALNAC1.

Gene Wiki entry for ST6GALNAC2 Gene

Additional gene information for ST6GALNAC2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST6GALNAC2 Gene

Genomics for ST6GALNAC2 Gene

GeneHancer (GH) Regulatory Elements for ST6GALNAC2 Gene

Promoters and enhancers for ST6GALNAC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I076584 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 573.6 +1.5 1518 2.4 ZFP64 ARID4B SIN3A ZNF2 ZNF48 ZNF121 GLIS2 ZNF213 KLF7 SP3 ST6GALNAC2 UNK EXOC7 MGAT5B ENSG00000284526 GC17M076570
GH17I076586 Enhancer 0.8 ENCODE 572.9 +0.0 22 0.4 PKNOX1 KLF17 ZNF76 ZNF2 ZNF121 ZNF366 SCRT2 ZNF398 TSHZ1 ZEB2 ST6GALNAC2 GC17M076587 GC17M076570 ENSG00000284526
GH17I075665 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.7 +919.6 919638 3.1 PKNOX1 SMAD1 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B RECQL5 SAP30BP SNHG16 ENSG00000266980 NUP85 MIF4GD SLC25A19 ENSG00000267078 SPHK1 ST6GALNAC2
GH17I075894 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9.7 +690.4 690431 3.3 HDGF CLOCK ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 TRIM65 ENSG00000267342 FBF1 SNHG16 MIF4GD ENSG00000267078 SPHK1 ST6GALNAC2 TRIM47
GH17I076577 Enhancer 0.8 ENCODE 23.6 +6.4 6350 6.5 BATF IRF4 TCF12 SCRT2 EGR2 ZEB2 ZNF592 ZNF217 SMARCA4 IKZF1 ST6GALNAC2 PRCD CYGB RNU6-227P UBE2O AANAT ENSG00000267543 ENSG00000284526 GC17M076570
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ST6GALNAC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ST6GALNAC2 gene promoter:

Genomic Locations for ST6GALNAC2 Gene

Genomic Locations for ST6GALNAC2 Gene
chr17:76,565,379-76,586,956
(GRCh38/hg38)
Size:
21,578 bases
Orientation:
Minus strand
chr17:74,559,792-74,583,038
(GRCh37/hg19)

Genomic View for ST6GALNAC2 Gene

Genes around ST6GALNAC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST6GALNAC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST6GALNAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST6GALNAC2 Gene

Proteins for ST6GALNAC2 Gene

  • Protein details for ST6GALNAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJ37-SIA7B_HUMAN
    Recommended name:
    Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
    Protein Accession:
    Q9UJ37
    Secondary Accessions:
    • Q12971

    Protein attributes for ST6GALNAC2 Gene

    Size:
    374 amino acids
    Molecular mass:
    41939 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Aberrant O-galactosylation of IgA1 molecules plays a role in the development and progression of IgA nephropathy (IgAN). Genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation, disease predisposition, and disease severity, and may contribute to the polygenic nature of IgAN.

neXtProt entry for ST6GALNAC2 Gene

Post-translational modifications for ST6GALNAC2 Gene

  • Glycosylation at isoforms=85, posLast=130130, and isoforms=161

Other Protein References for ST6GALNAC2 Gene

No data available for DME Specific Peptides for ST6GALNAC2 Gene

Domains & Families for ST6GALNAC2 Gene

Gene Families for ST6GALNAC2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ST6GALNAC2 Gene

Suggested Antigen Peptide Sequences for ST6GALNAC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJ37

UniProtKB/Swiss-Prot:

SIA7B_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST6GALNAC2: view

Function for ST6GALNAC2 Gene

Molecular function for ST6GALNAC2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
CMP-N-acetylneuraminate + glycano-beta-D-galactosyl-1,3-(N-acetyl-D-galactosaminyl)-glycoprotein = CMP + glycano-beta-D-galactosyl-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein.

Enzyme Numbers (IUBMB) for ST6GALNAC2 Gene

Gene Ontology (GO) - Molecular Function for ST6GALNAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity TAS --
GO:0008373 sialyltransferase activity TAS,IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ST6GALNAC2: view
genes like me logo Genes that share phenotypes with ST6GALNAC2: view

Animal Models for ST6GALNAC2 Gene

MGI Knock Outs for ST6GALNAC2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ST6GALNAC2 Gene

Localization for ST6GALNAC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST6GALNAC2 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST6GALNAC2 gene
Compartment Confidence
golgi apparatus 4
extracellular 2
plasma membrane 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ST6GALNAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST6GALNAC2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ST6GALNAC2 Gene

Pathways & Interactions for ST6GALNAC2 Gene

genes like me logo Genes that share pathways with ST6GALNAC2: view

UniProtKB/Swiss-Prot Q9UJ37-SIA7B_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for ST6GALNAC2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000225276%0d%0a9606.ENSP00000417498%0d%0a9606.ENSP00000302021%0d%0a9606.ENSP00000381008%0d%0a9606.ENSP00000406861%0d%0a9606.ENSP00000311364%0d%0a
Selected Interacting proteins: ENSP00000225276 Q9UJ37-SIA7B_HUMAN for ST6GALNAC2 Gene via STRING IID MINT

Gene Ontology (GO) - Biological Process for ST6GALNAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0009311 oligosaccharide metabolic process IBA --
GO:0016266 O-glycan processing TAS --
GO:0018279 protein N-linked glycosylation via asparagine IBA --
GO:0097503 sialylation IBA,IEA --
genes like me logo Genes that share ontologies with ST6GALNAC2: view

No data available for SIGNOR curated interactions for ST6GALNAC2 Gene

Drugs & Compounds for ST6GALNAC2 Gene

(1) Drugs for ST6GALNAC2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine monophosphate Experimental Pharma 0

(1) Additional Compounds for ST6GALNAC2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-Acetylneuraminate
  • CMP-N-Acylneuraminate
  • CMP-NeuNAc
  • Cytidine 5'-monophosphate N-acetylneuraminic acid
  • Cytidine Monophosphate N-Acetylneuraminate
22-12-8
genes like me logo Genes that share compounds with ST6GALNAC2: view

Transcripts for ST6GALNAC2 Gene

Unigene Clusters for ST6GALNAC2 Gene

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
SP1: - - - -
SP2: -
SP3: - -
SP4:
SP5: -
SP6:

Relevant External Links for ST6GALNAC2 Gene

GeneLoc Exon Structure for
ST6GALNAC2
ECgene alternative splicing isoforms for
ST6GALNAC2

Expression for ST6GALNAC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST6GALNAC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST6GALNAC2 Gene

This gene is overexpressed in Nerve - Tibial (x7.4), Testis (x6.1), and Whole Blood (x5.2).

Protein differential expression in normal tissues from HIPED for ST6GALNAC2 Gene

This gene is overexpressed in Synovial fluid (55.7) and Placenta (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ST6GALNAC2 Gene



Protein tissue co-expression partners for ST6GALNAC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ST6GALNAC2 Gene:

ST6GALNAC2

SOURCE GeneReport for Unigene cluster for ST6GALNAC2 Gene:

Hs.592105

mRNA Expression by UniProt/SwissProt for ST6GALNAC2 Gene:

Q9UJ37-SIA7B_HUMAN
Tissue specificity: Expressed in skeletal muscle, heart, kidney, placenta, lung and leukocytes.

Evidence on tissue expression from TISSUES for ST6GALNAC2 Gene

  • Skin(4.3)
genes like me logo Genes that share expression patterns with ST6GALNAC2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ST6GALNAC2 Gene

Orthologs for ST6GALNAC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST6GALNAC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST6GALNAC2 33 34
  • 97.95 (n)
dog
(Canis familiaris)
Mammalia ST6GALNAC2 33 34
  • 85.83 (n)
cow
(Bos Taurus)
Mammalia ST6GALNAC2 33 34
  • 83.82 (n)
mouse
(Mus musculus)
Mammalia St6galnac2 33 16 34
  • 79.36 (n)
rat
(Rattus norvegicus)
Mammalia St6galnac2 33
  • 79.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ST6GALNAC2 34
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ST6GALNAC2 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves ST6GALNAC2 33 34
  • 63.54 (n)
lizard
(Anolis carolinensis)
Reptilia ST6GALNAC2 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st6galnac2 33
  • 62.66 (n)
siat7b 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15681 33
zebrafish
(Danio rerio)
Actinopterygii st6galnac2 33
  • 59.31 (n)
ST6GALNAC2 34
  • 49 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11887 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4378 34
  • 22 (a)
OneToMany
Species where no ortholog for ST6GALNAC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST6GALNAC2 Gene

ENSEMBL:
Gene Tree for ST6GALNAC2 (if available)
TreeFam:
Gene Tree for ST6GALNAC2 (if available)

Paralogs for ST6GALNAC2 Gene

Paralogs for ST6GALNAC2 Gene

(2) SIMAP similar genes for ST6GALNAC2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ST6GALNAC2 Gene

genes like me logo Genes that share paralogs with ST6GALNAC2: view

Variants for ST6GALNAC2 Gene

Sequence variations from dbSNP and Humsavar for ST6GALNAC2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000031746 -- 76,566,938(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000093147 -- 76,586,256(-) C/G upstream_transcript_variant
rs1000111407 -- 76,571,112(-) T/C intron_variant
rs1000167981 -- 76,584,253(-) C/T intron_variant
rs1000392070 -- 76,577,060(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ST6GALNAC2 Gene

Variant ID Type Subtype PubMed ID
esv28008 CNV loss 19812545
esv3641290 CNV gain 21293372
esv3641291 CNV gain 21293372
nsv1071403 CNV deletion 25765185
nsv828107 CNV loss 20364138

Variation tolerance for ST6GALNAC2 Gene

Residual Variation Intolerance Score: 60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST6GALNAC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST6GALNAC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST6GALNAC2 Gene

Disorders for ST6GALNAC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ST6GALNAC2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ST6GALNAC2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ST6GALNAC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST6GALNAC2 Gene

Publications for ST6GALNAC2 Gene

  1. Interaction between variants of two glycosyltransferase genes in IgA nephropathy. (PMID: 19357720) Zhu L … Wang H (Kidney international 2009) 3 4 44 58
  2. Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells. (PMID: 10742600) Samyn-Petit B … Harduin-Lepers A (Biochimica et biophysica acta 2000) 3 4 22 58
  3. Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy. (PMID: 17480010) Li GS … Wang HY (Human mutation 2007) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Identification and functional characterization of a human GalNAc [alpha]2,6-sialyltransferase with altered expression in breast cancer. (PMID: 11984005) Sotiropoulou G … Sager R (Molecular medicine (Cambridge, Mass.) 2002) 2 22 58

Products for ST6GALNAC2 Gene

Sources for ST6GALNAC2 Gene

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