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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ST6GALNAC2 Gene

protein-coding GIFtS: 57
GCID: GC17M074561

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide...

(Previous names: sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl...)
(Previous symbols: SIAT7, SIAT7B, SIATL1)

Explore 4 diseases affiliated with
ST6GALNAC2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2¹ ²		ST6GalNAc II² ³
SIAT7B¹ ² ³		Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase)¹
SIATL1¹ ² ³		(Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase²
STHM¹ ² ³		(Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide B²
SIAT7¹ ²		SAITL1²
ST6GalNAII¹ ²		Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2²
Sialyltransferase-Like 1¹ ²		Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) B²
GalNAc Alpha-2,6-Sialyltransferase II² ³		Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide B²
Sialyltransferase 7B² ³		EC 2.4.99.-³
SIAT7-B² ³		SThM³
ST6GalNAcII² ³

External Ids:	HGNC: 10867¹	Entrez Gene: 10610²	Ensembl: ENSG00000070731⁷	OMIM: 610137⁵	UniProtKB: Q9UJ37³

Export aliases for ST6GALNAC2 gene to outside databases

Previous GC identifers: GC17M072074 GC17M069989

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ST6GALNAC2:

ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates.

At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion,

and protein targeting (Samyn-Petit et al., 2000 (PubMed 10742600)).(supplied by OMIM, Mar 2008)

Gene Wiki entry for ST6GALNAC2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ST6GALNAC2 gene promoter:
Egr-3 GATA-3 p53 Pax-5 Evi-1 Egr-2 FOXO4 Pax-4a LyF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ST6GALNAC2 promoter sequence

Search SABiosciences Chromatin IP Primers for ST6GALNAC2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST6GALNAC2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.1

ST6GALNAC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST6GALNAC2 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M074561: view genomic region (about GC identifiers)

Start:	74,559,792 bp from pter	End:	74,583,038 bp from pter
Size:	23,247 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SIA7B_HUMAN, Q9UJ37 (See protein sequence)

Recommended Name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2

Size: 374 amino acids; 41939 Da

Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)

Miscellaneous: Aberrant O-galactosylation of IgA1 molecules plays a role in the development and progression of IgA

nephropathy (IgAN). Genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation, disease

predisposition, and disease severity, and may contribute to the polygenic nature of IgAN

Secondary accessions: Q12971

Explore the universe of human proteins at neXtProt for ST6GALNAC2: NX_Q9UJ37

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UJ37

ST6GALNAC2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006447.2

ENSEMBL proteins:

ENSP00000225276 ENSP00000464915 ENSP00000466560 ENSP00000465778 ENSP00000466513

Reactome Protein details: Q9UJ37
Human Recombinant Protein Products for ST6GALNAC2:

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	Uscn Proteins for ST6GALNAC2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	--
GO:0030173	integral to Golgi membrane	IEA	--

ST6GALNAC2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ST6GALNAC2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ST6GALNAC2 for domains About GeneDecksing

2 InterPro domains/families:

IPR001675 Glyco_trans_29

IPR012163 Sialyl_trans

Graphical View of Domain Structure for InterPro Entry Q9UJ37

ProtoNet protein and cluster: Q9UJ37

1 Blocks protein family: IPB001675 Glycosyl transferase

UniProtKB/Swiss-Prot: SIA7B_HUMAN, Q9UJ37

Similarity: Belongs to the glycosyltransferase 29 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SIA7B_HUMAN, Q9UJ37

Catalytic activity: CMP-N-acetylneuraminate + glycano-beta-D-galactosyl-1,3-(N-acetyl-D-galactosaminyl)-glycoprotein =

CMP + glycano-beta-D-galactosyl-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein

Enzyme Number (IUBMB): EC 2.4.99.-¹

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008373	sialyltransferase activity	IEA	--

ST6GALNAC2 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for ST6GALNAC2:

Increased cell death HMECs cel

Increased gamma-H2AX phosphory

1 MGI phenotypic allele

for St6galnac2 (no phenotypes)

ST6GALNAC2 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ST6GALNAC2

miRNA Products:		OriGene 3'-UTR Clone: ST6GALNAC2 Browse MicroRNA Expression Plasmids
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		hsa-miR-623 hsa-miR-298 hsa-miR-2116
		SwitchGear 3'UTR luciferase reporter plasmid: ST6GALNAC2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST6GALNAC2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein

Termination of O-glycan biosynthesis

0.69

O-linked glycosylation of mucins

0.28

Asparagine N-linked glycosylation

Post-translational protein modification

0.44

Metabolism of proteins

0.15

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for ST6GALNAC2

	O-linked glycosylation of mucins
	Metabolism of proteins
	Post-translational protein modification
	Termination of O-glycan biosynthesis

UniProtKB/Swiss-Prot: SIA7B_HUMAN, Q9UJ37

Pathway: Protein modification; protein glycosylation

ST6GALNAC2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ST6GALNAC2

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/15 Interacting proteins for ST6GALNAC2 (Q9UJ37^{2, 3} ENSP00000225276⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMAD3	P84022²^,³	MINT-61718 I2D: score=3
MUC1	ENSP00000338983⁴	STRING: ENSP00000338983
MUC2	ENSP00000415183⁴	STRING: ENSP00000415183
MUC20	ENSP00000396774⁴	STRING: ENSP00000396774
MUC12	ENSP00000368755⁴	STRING: ENSP00000368755

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016266	O-glycan processing	TAS	--
GO:0043687	post-translational protein modification	TAS	--
GO:0044267	cellular protein metabolic process	TAS	--

ST6GALNAC2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ST6GALNAC2
Search CenterWatch for drugs/clinical trials and news about ST6GALNAC2 / SIA7B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ST6GALNAC2 gene:

NM_006456.2

Unigene Cluster for ST6GALNAC2:

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2

Hs.592105 [show with all ESTs]

Unigene Representative Sequence: NM_006456

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000589997 ENST00000225276(uc002jsg.4) ENST00000585390 ENST00000588920

ENST00000592979 ENST00000588120 ENST00000586520 ENST00000588005 ENST00000585736

ENST00000592508

miRNA Products:		OriGene 3'-UTR Clone: ST6GALNAC2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST6GALNAC2
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate ST6GALNAC2:
		hsa-miR-623 hsa-miR-298 hsa-miR-2116
		SwitchGear 3'UTR luciferase reporter plasmid: ST6GALNAC2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AJ251053.1 AK225943.1 BT019972.1 U14550.1

11 DOTS entries:

DT.75145294 DT.99976584 DT.120982351 DT.100828311 DT.100021745 DT.100796373 DT.92443381 DT.95216805

DT.100796378 DT.91984147 DT.95216803

24/159 AceView cDNA sequences (see all 159):

BQ424322 CB410651 CA419632 CA392645 AI375909 CB410770 AW873476 AU141538

BQ773939 AI184687 AA497128 AI922174 CA489243 BM705458 BQ882535 AA456371

BC040455 AA497051 BQ430220 CD369451 BG542529 AA608996 BM709750 AI458633

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC2 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	^	9	^	10a	·	10b	·	10c
SP1:							-		-										-										-
SP2:																													-
SP3:							-		-
SP4:
SP5:									-

ECgene alternative splicing isoforms for ST6GALNAC2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ST6GALNAC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGATGACTC

About this image

ST6GALNAC2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Definitive endoderm-like cells (Generation and expan...)

Endoderm progenitor-like cells (Generation and expan...)

Definitive endoderm-like cells (A scalable, suspensi...)

HyStem+BMP4-induced SK11 cells (HyStem+BMP4 inductio...)

Bone, Cartilage

HyStem+BMP4-induced SM30 cells (HyStem+BMP4 inductio...)

Adipose, Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ST6GALNAC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ST6GALNAC2

SOURCE GeneReport for Unigene cluster: Hs.592105

UniProtKB/Swiss-Prot: SIA7B_HUMAN, Q9UJ37

Tissue specificity: Expressed in skeletal muscle, heart, kidney, placenta, lung and leukocytes

SABiosciences Custom PCR Arrays for ST6GALNAC2

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST6GALNAC2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ST6GALNAC2 gene from 4/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ST6GALNAC2¹	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more	63.45(n) 61.39(a)		396159 NM_205233.1 NP_990564.1
lizard (Anolis carolinensis)	Reptilia	ST6GALNAC2⁶	--	63(a)	1 ↔ 1	2(111880503-111891744)
African clawed frog (Xenopus laevis)	Amphibia	Xl.15681²	Xenopus laevis transcribed sequence with moderate similarity more	76.28(n)		BJ624886.1
zebrafish (Danio rerio)	Actinopterygii	st6galnac2¹	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more	59.26(n) 57.71(a)		100001225 NM_001171222.1 NP_001164693.1

ENSEMBL Gene Tree for ST6GALNAC2 (if available)
TreeFam Gene Tree for ST6GALNAC2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ST6GALNAC2 gene

ST3GAL3² ST6GALNAC1² ST3GAL6² ST3GAL1² ST3GAL4² ST3GAL5² ST3GAL2²

2 SIMAP similar genes for ST6GALNAC2 using alignment to 5 protein entries: SIA7B_HUMAN (see all proteins):

ST3GAL1 ST6GALNAC1

ST6GALNAC2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ST6GALNAC2
PGOHUM00000240117

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs181867219^1,2		--	74560972(+)	`GAAATC/GTCTCT`	5	--	nc-transcript-variantds500¹		0	--	--	--	--
rs8038^1,2	C,F,A,H	--	74561101(+)	`GTTTCG/ATTTCT`	5	--	ds500¹ nc-transcript-variant		6		NA MN WA	312
rs200617100^1,2		--	74561112(+)	`GTGAC-/TTGAGT`	5	--	nc-transcript-variantds500¹		0	--	--	--	--
rs28692957^1,2		--	74561161(+)	`AAAGAA/GTCCAC`	5	--	nc-transcript-variantds500¹		0	--	--	--	--
rs7352^1,2	C,F,A,H	--	74561213(+)	`ACGTAA/GCTGAT`	5	--	ds500¹ nc-transcript-variant		14		NS EA NA MN	2160
rs17841620^1,2	F	--	74561226(-)	`CTTCCT/CGAGGC`	5	--	ds500¹ nc-transcript-variant		2		MN NA	304
rs3837794^1,2	C	--	74561258(+)	`GAAGA-/CCCCCC`	5	--	nc-transcript-variantds500¹		2		NA CSA	4
rs111235846^1,2	C	--	74561265(+)	`CCCCTT/CCTCCC`	5	--	nc-transcript-variantds500¹		1		CSA	1
rs13022^1,2	F	--	74561300(-)	`CTGAGA/GTGCTT`	5	--	nc-transcript-variantds500¹		1		NA	120
rs149019020^1,2		--	74561316(+)	`GCAAAA/GCCGTG`	5	--	ds500¹ nc-transcript-variant		0	--	--	--	--

HapMap Linkage Disequilibrium report for ST6GALNAC2 (74559792 - 74583038 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ST6GALNAC2
1 CNV: 67266

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ST6GALNAC2 for disorders           About GeneDecksing

OMIM gene information: 610137    OMIM disorders: --

4 diseases for ST6GALNAC2:    About MalaCards

iga glomerulonephritis glomerulonephritis nephropathy breast cancer

1 disease from the University of Copenhagen DISEASES database for ST6GALNAC2:

IgA glomerulonephritis

Human Genome Epidemiology (HuGE) Navigator: ST6GALNAC2 (2 documents)

Export disorders for ST6GALNAC2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ST6GALNAC2 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with ST6GALNAC2)

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Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells. (PubMed id 10742600)^{1, 2, 9} Samyn-Petit B....Harduin-Lepers A. (2000)
Interaction between variants of two glycosyltransferase genes in IgA nephropathy. (PubMed id 19357720)^{1, 2} Zhu L.... Wang H. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification and functional characterization of a human GalNAc [alpha]2,6-sialyltransferase with altered expression in breast cancer. (PubMed id 11984005)^{3, 9} Sotiropoulou G....Sager R. (2002)
Activity of alpha2,6-sialyltransferase and its gene expression in peripheral B lymphocytes in patients with IgA nephropathy. (PubMed id 19170967)¹ Ding J.X....Wang H.Y. (2009)
Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy. (PubMed id 17480010)¹ Li G.S....Wang H.Y. (2007)
Identification and characterization of CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase in IgA1-producing cells. (PubMed id 17418236)¹ Raska M....Novak J. (2007)
Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)¹ Colland F....Gauthier J.M. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10610	HGNC: 10867	AceView: SIAT7B	Ensembl:ENSG00000070731	euGenes: HUgn10610
ECgene: ST6GALNAC2	H-InvDB: ST6GALNAC2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ST6GALNAC2	Pharmacogenomics, SNPs, Pathways
GGDB	http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST6GALNAC2
Functional Glycomics Gateway - GTase	http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_631

Intellectual Property for ST6GALNAC2 gene
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Patent Information for ST6GALNAC2 gene:
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ST6GALNAC2 Gene

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide...

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ST6GALNAC2 (Gene Symbol)
ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2
SIAT7B
SIATL1
STHM
SIAT7
ST6GalNAII
Sialyltransferase-Like 1
GalNAc Alpha-2,6-Sialyltransferase II
Sialyltransferase 7B
SIAT7-B
ST6GalNAcII
ST6GalNAc II
Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase)
(Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase
(Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide B
SAITL1
Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2
Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) B
Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide B
EC 2.4.99.-
SThM

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ST6GALNAC2 Gene

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide...

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