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ST6GALNAC1 Gene

protein-coding   GIFtS: 53
GCID: GC17M074620

ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide...

(Previous name: sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl...)
(Previous symbol: SIAT7A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ST6
(Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide
Alpha-2,6-Sialyltransferase 11 2
     ST6GalNAc I2 3
SIAT7A1 2 3 5     STYI2 5
Sialyltransferase 7
((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl
Galactosaminide Alpha-2,6-Sialyltransferase) A1 2
     HSY113392
GalNAc Alpha-2,6-Sialyltransferase I2 3     Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 12
Sialyltransferase 7A2 3     GalNAc Alpha-2, 6-Sialyltransferase I, Long Form2
SIAT7-A2 3     EC 2.4.99.33
ST6GalNAcI2 3     

External Ids:    HGNC: 236141   Entrez Gene: 558082   Ensembl: ENSG000000705267   OMIM: 6101385   UniProtKB: Q9NSC73   

Export aliases for ST6GALNAC1 gene to outside databases

Previous GC identifers: GC17M072133 GC17M070050


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ST6GALNAC1 Gene:
Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of
intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6
linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by
ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 (PubMed 10536037); Sewell et
al., 2006 (PubMed 16319059)).(supplied by OMIM, Mar 2008)

GeneCards Summary for ST6GALNAC1 Gene:
ST6GALNAC1 (ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1) is a protein-coding gene. Diseases associated with ST6GALNAC1 include colon adenocarcinoma, and colorectal cancer. GO annotations related to this gene include alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity and sialyltransferase activity. An important paralog of this gene is ST3GAL3.

Gene Wiki entry for ST6GALNAC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ST6GALNAC1 gene promoter:
         Nkx3-1   Nkx3-1 v4   GR-beta   Nkx3-1 v1   RORalpha2   Nkx3-1 v2   Zic1   Nkx3-1 v3   GR-alpha   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidST6GALNAC1 promoter sequence
   Search Chromatin IP Primers for ST6GALNAC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST6GALNAC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.3

ST6GALNAC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST6GALNAC1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M074620:  view genomic region     (about GC identifiers)

Start:
74,620,843 bp from pter      End:
74,639,920 bp from pter
Size:
19,078 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SIA7A_HUMAN, Q9NSC7 (See protein sequence)
Recommended Name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1  
Size: 600 amino acids; 68564 Da
Secondary accessions: Q6UW90 Q9NSC6

Explore the universe of human proteins at neXtProt for ST6GALNAC1: NX_Q9NSC7

Explore proteomics data for ST6GALNAC1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn300, Asn311, Asn331, Asn375, Asn460, Thr595
  • Modification sites at PhosphoSitePlus

  • See ST6GALNAC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001276036.1  NP_060884.1  

    ENSEMBL proteins: 
     ENSP00000465092   ENSP00000351991   ENSP00000156626   ENSP00000466230   ENSP00000466436  
     ENSP00000465116   ENSP00000468784  
    Reactome Protein details: Q9NSC7

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ST3G: Sialyltransferases

    1 InterPro protein domain:
     IPR001675 Glyco_trans_29

    Graphical View of Domain Structure for InterPro Entry Q9NSC7

    ProtoNet protein and cluster: Q9NSC7

    1 Blocks protein domain: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIA7A_HUMAN, Q9NSC7
    Similarity: Belongs to the glycosyltransferase 29 family


    ST6GALNAC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIA7A_HUMAN, Q9NSC7
    Catalytic activity: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP
    + glycano-((2->6)-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein

         Enzyme Number (IUBMB): EC 2.4.99.31

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001665alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IEA--
    GO:0008373sialyltransferase activity NAS10536037
         
    ST6GALNAC1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ST6GALNAC1
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    miRNA
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    miRTarBase miRNAs that target ST6GALNAC1:
    hsa-mir-335-5p (MIRT016766)

    Block miRNA regulation of human, mouse, rat ST6GALNAC1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate ST6GALNAC1:
    hsa-miR-4328 hsa-miR-1283
    SwitchGear 3'UTR luciferase reporter plasmidST6GALNAC1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST6GALNAC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIA7A_HUMAN, Q9NSC7: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005794Golgi apparatus ----
    GO:0016021integral component of membrane IEA--

    ST6GALNAC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ST6GALNAC1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1O-linked glycosylation of mucins
    Mucin type O-Glycan biosynthesis0.47
    2Metabolism
    Metabolic pathways0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ST6GALNAC1
        Sialic acid metabolism


    2 Kegg Pathways  (Kegg details for ST6GALNAC1):
        Mucin type O-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: SIA7A_HUMAN, Q9NSC7
    Pathway: Protein modification; protein glycosylation


    ST6GALNAC1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ST6GALNAC1: 

              Glycosylation in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ST6GALNAC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ST6GALNAC1 (ENSP000001566264) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    B3GNT6ENSP000003462564STRING: ENSP00000346256
    C1GALT1ENSP000002231224STRING: ENSP00000223122
    C1GALT1C1ENSP000003043644STRING: ENSP00000304364
    GALNT1ENSP000002691954STRING: ENSP00000269195
    GALNT12ENSP000003641504STRING: ENSP00000364150
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation NAS10536037
    GO:0009312oligosaccharide biosynthetic process IEA--
    GO:0097503sialylation NAS10536037

    ST6GALNAC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ST6GALNAC1 (SIA7A)

    1 Novoseek inferred chemical compound relationship for ST6GALNAC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sialic acid 72 2 15770530 (1), 16135558 (1)



    ST6GALNAC1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ST6GALNAC1 gene (2 alternative transcripts): 
    NM_001289107.1  NM_018414.4  

    Unigene Cluster for ST6GALNAC1:

    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
    Hs.105352  [show with all ESTs]
    Unigene Representative Sequence: BC063830
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592042 ENST00000359088 ENST00000156626(uc002jsh.3 uc002jsi.3 uc002jsj.3)
    ENST00000585633 ENST00000588375 ENST00000590784 ENST00000589004 ENST00000590878
    ENST00000589813 ENST00000590915 ENST00000589992
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate ST6GALNAC1:
    hsa-miR-4328 hsa-miR-1283
    SwitchGear 3'UTR luciferase reporter plasmidST6GALNAC1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ST6GALNAC1
      QuantiFast Probe-based Assays in human, mouse, rat ST6GALNAC1

    Additional mRNA sequence: 

    AK000113.1 AK310906.1 AY096001.1 AY358918.1 BC022462.1 BC063830.1 Y11339.2 

    8 DOTS entries:

    DT.95167162  DT.100023579  DT.305981  DT.436637  DT.100787208  DT.97843343  DT.100787212  DT.97783275 

    Selected AceView cDNA sequences (see all 109):

    AA494414 AY096001 BG982580 CB147534 AL544554 AL556596 AI858216 BG982591 
    CA432681 BG984953 BC063830 BG982660 AA514491 AL709089 BU190870 AY358918 
    CB156507 BX089008 AI858970 CF139911 BX951360 CB243428 CB130001 CB851698 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:                                -     -                                                                             -               
    SP2:                                -     -                                                     -     -                 -               
    SP3:                                                                                                  -                 -               
    SP4:                                                                                            -     -                                 
    SP5:                                -                                                                                                   


    ECgene alternative splicing isoforms for ST6GALNAC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ST6GALNAC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAGGCAAA
    ST6GALNAC1 Expression
    About this image

    ST6GALNAC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ST6GALNAC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.105352
        Pathway & Disease-focused RT2 Profiler PCR Array including ST6GALNAC1: 
              Glycosylation in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat ST6GALNAC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST6GALNAC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ST6GALNAC1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St6galnac11 , 5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more1, 5 75.87(n)1
    72.39(a)1
      11 (81.49 cM)5
    204451  NM_011371.21  NP_035501.21 
     1167650255 
    chicken
    (Gallus gallus)
    Aves ST6GALNAC11 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more 67.31(n)
    64.27(a)
      396168  NM_205240.1  NP_990571.1 
    lizard
    (Anolis carolinensis)
    Reptilia ST6GALNAC16
    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl...
    44(a)
    1 ↔ 1
    2(111802512-111830540)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia st6galnac11 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more 55.68(n)
    50.28(a)
      101733431  XM_004918441.1  XP_004918498.1 
    zebrafish
    (Danio rerio)
    Actinopterygii st6galnac1.11 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide more 52.78(n)
    47.85(a)
      564336  XM_003199600.2  XP_003199648.1 


    ENSEMBL Gene Tree for ST6GALNAC1 (if available)
    TreeFam Gene Tree for ST6GALNAC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ST6GALNAC1 gene
    ST3GAL32  ST3GAL62  ST6GALNAC22  ST3GAL12  ST3GAL42  ST3GAL22  ST3GAL52  
    2 SIMAP similar genes for ST6GALNAC1 using alignment to 7 protein entries:     SIA7A_HUMAN (see all proteins):
    ST6GALNAC2    ST3GAL1

    ST6GALNAC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ST6GALNAC1 (see all 555)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1860917901,2
    --74620420(+) TCTGCC/TCCCCA 1 -- int10--------
    rs1400309081,2
    --74620488(+) CACCAC/TGCCCG 1 -- int10--------
    rs340792771,2
    C,F--74620520(+) AGAGAC/TGGGGT 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1833187041,2
    --74620655(+) GGGTTA/GTTCCA 1 -- int10--------
    rs1167411351,2
    F--74620699(+) AAAGGG/ATAAGG 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1864849791,2
    --74620814(+) CTGGTC/TCCTAT 1 -- int10--------
    rs7175711,2
    C,F,O,A,H--74620823(-) ACTCCA/CTGGAT 1 -- int124Minor allele frequency- C:0.26NA EA MN NS 2430
    rs1472539531,2
    --74620842(+) GTTGCA/GTCTTC 1 -- int10--------
    rs1143175441,2
    F--74620940(+) TTAAAG/AACAAG 1 -- ut311Minor allele frequency- A:0.02WA 118
    rs1399611941,2
    --74621166(+) CCACCA/CATCAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ST6GALNAC1 (74620843 - 74639920 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ST6GALNAC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716257CNV Deletion23290073
    esv2671702CNV Deletion23128226
    esv269901CNV Insertion20981092
    nsv820158CNV Gain19587683
    nsv518385CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ST6GALNAC1
    DNA2.0 Custom Variant and Variant Library Synthesis for ST6GALNAC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610138    OMIM disorders: --

    4 diseases for ST6GALNAC1:    About MalaCards
    colon adenocarcinoma    colorectal cancer    breast cancer    adenocarcinoma


    ST6GALNAC1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for ST6GALNAC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 33.5 7 16135558 (4), 12820722 (2), 15770530 (1)
    colorectal cancer 28.3 1 15539921 (1)

    Genetic Association Database (GAD): ST6GALNAC1
    Human Genome Epidemiology (HuGE) Navigator: ST6GALNAC1 (1 document)

    Export disorders for ST6GALNAC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ST6GALNAC1 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with ST6GALNAC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of a human gene encoding an N- acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNac I); a candidate for synthesis of cancer-associated sialyl-Tnantigens. (PubMed id 10536037)1, 2, 9 Ikehara Y.... Narimatsu H. (Glycobiology 1999)
    2. Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA. (PubMed id 12820722)1, 2, 9 Julien S.... Delannoy P. (Glycoconj. J. 2001)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human breast cancer. (PubMed id 16319059)1, 9 Sewell R....Taylor-Papadimitriou J. (J. Biol. Chem. 2006)
    6. Enhancement of metastatic ability by ectopic expression of ST6GalNAcI on a gastric cancer cell line in a mouse model. (PubMed id 22228572)1 Ozaki H....Narimatsu H. (amp 2012)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Golgi N-glycosyltransferases form both homo- and heterodimeric enzyme complexes in live cells. (PubMed id 20378551)1 Hassinen A....Kellokumpu S. (J. Biol. Chem. 2010)
    9. Prognostic utility of glycosyltransferase expression in breast cancer. (PubMed id 19287074)1 Patani N....Mokbel K. (amp 2008)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55808 HGNC: 23614 AceView: SIAT7A Ensembl:ENSG00000070526 euGenes: HUgn55808
    ECgene: ST6GALNAC1 Kegg: 55808 H-InvDB: ST6GALNAC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ST6GALNAC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ST6GALNAC1 Genetics and Cytogenetics in Oncology and Haematology
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST6GALNAC1
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_630

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ST6GALNAC1 gene:
    Search GeneIP for patents involving ST6GALNAC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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