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Aliases for ST6GALNAC1 Gene

Aliases for ST6GALNAC1 Gene

  • ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 1 2 3
  • SIAT7A 3 4 6
  • Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) A 2 3
  • GalNAc Alpha-2,6-Sialyltransferase I 3 4
  • Sialyltransferase 7A 3 4
  • ST6GalNAc I 3 4
  • ST6GalNAcI 3 4
  • SIAT7-A 3 4
  • STYI 3 6
  • Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 1 3
  • GalNAc Alpha-2, 6-Sialyltransferase I, Long Form 3
  • EC 4
  • HSY11339 3

External Ids for ST6GALNAC1 Gene

Previous HGNC Symbols for ST6GALNAC1 Gene

  • SIAT7A

Previous GeneCards Identifiers for ST6GALNAC1 Gene

  • GC17M072133
  • GC17M074620
  • GC17M070050

Summaries for ST6GALNAC1 Gene

Entrez Gene Summary for ST6GALNAC1 Gene

  • Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ST6GALNAC1 Gene

ST6GALNAC1 (ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 1) is a Protein Coding gene. Among its related pathways are Metabolism and O-linked glycosylation of mucins. GO annotations related to this gene include sialyltransferase activity and alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. An important paralog of this gene is ST3GAL4.

Gene Wiki entry for ST6GALNAC1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST6GALNAC1 Gene

Genomics for ST6GALNAC1 Gene

Regulatory Elements for ST6GALNAC1 Gene

Genomic Location for ST6GALNAC1 Gene

76,624,756 bp from pter
76,643,838 bp from pter
19,083 bases
Minus strand

Genomic View for ST6GALNAC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ST6GALNAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST6GALNAC1 Gene

Proteins for ST6GALNAC1 Gene

  • Protein details for ST6GALNAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
    Protein Accession:
    Secondary Accessions:
    • Q6UW90
    • Q9NSC6

    Protein attributes for ST6GALNAC1 Gene

    600 amino acids
    Molecular mass:
    68564 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST6GALNAC1 Gene

Proteomics data for ST6GALNAC1 Gene at MOPED

Post-translational modifications for ST6GALNAC1 Gene

  • Glycosylation at Asn300, Asn311, Asn331, Asn375, Asn460, and Thr595
  • Modification sites at PhosphoSitePlus

Other Protein References for ST6GALNAC1 Gene

Antibody Products

No data available for DME Specific Peptides for ST6GALNAC1 Gene

Domains for ST6GALNAC1 Gene

Gene Families for ST6GALNAC1 Gene

  • ST3G :Sialyltransferases

Protein Domains for ST6GALNAC1 Gene

Suggested Antigen Peptide Sequences for ST6GALNAC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9NSC7
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST6GALNAC1: view

Function for ST6GALNAC1 Gene

Molecular function for ST6GALNAC1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-((2->6)-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein

Enzyme Numbers (IUBMB) for ST6GALNAC1 Gene

Gene Ontology (GO) - Molecular Function for ST6GALNAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IEA --
GO:0008373 sialyltransferase activity NAS 10536037
genes like me logo Genes that share ontologies with ST6GALNAC1: view

miRNA for ST6GALNAC1 Gene

miRTarBase miRNAs that target ST6GALNAC1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ST6GALNAC1

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ST6GALNAC1 Gene

Localization for ST6GALNAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST6GALNAC1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for ST6GALNAC1 Gene COMPARTMENTS Subcellular localization image for ST6GALNAC1 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ST6GALNAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST6GALNAC1: view

Pathways for ST6GALNAC1 Gene

genes like me logo Genes that share pathways with ST6GALNAC1: view

Pathways by source for ST6GALNAC1 Gene

2 KEGG pathways for ST6GALNAC1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9NSC7-SIA7A_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for ST6GALNAC1 Gene

Gene Ontology (GO) - Biological Process for ST6GALNAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation NAS 10536037
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0009312 oligosaccharide biosynthetic process IEA --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ST6GALNAC1: view

Compounds for ST6GALNAC1 Gene

(1) Novoseek inferred chemical compound relationships for ST6GALNAC1 Gene

Compound -log(P) Hits PubMed IDs
sialic acid 72 2
genes like me logo Genes that share compounds with ST6GALNAC1: view

Transcripts for ST6GALNAC1 Gene

Unigene Clusters for ST6GALNAC1 Gene

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ST6GALNAC1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5: -
SP6: - - - -
SP7: -

Relevant External Links for ST6GALNAC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ST6GALNAC1 Gene

mRNA expression in normal human tissues for ST6GALNAC1 Gene

mRNA differential expression in normal tissues according to GTEx for ST6GALNAC1 Gene

This gene is overexpressed in Colon - Transverse (18.9), Stomach (6.4), and Small Intestine - Terminal Ileum (5.4).

Protein differential expression in normal tissues for ST6GALNAC1 Gene

This gene is overexpressed in Serum (33.8), Cervix (7.2), and Oral epithelium (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ST6GALNAC1 Gene

SOURCE GeneReport for Unigene cluster for ST6GALNAC1 Gene Hs.105352

genes like me logo Genes that share expressions with ST6GALNAC1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Expression partners for ST6GALNAC1 Gene

Orthologs for ST6GALNAC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST6GALNAC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ST6GALNAC1 35
  • 78 (n)
  • 69.22 (a)
  • 68 (a)
(Canis familiaris)
Mammalia ST6GALNAC1 35
  • 75.2 (n)
  • 66.84 (a)
  • 66 (a)
(Mus musculus)
Mammalia St6galnac1 35
  • 75.87 (n)
  • 72.39 (a)
St6galnac1 16
St6galnac1 36
  • 67 (a)
(Pan troglodytes)
Mammalia ST6GALNAC1 35
  • 98.98 (n)
  • 98.81 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia St6galnac1 35
  • 76.97 (n)
  • 72.59 (a)
(Ornithorhynchus anatinus)
Mammalia ST6GALNAC1 36
  • 67 (a)
(Gallus gallus)
Aves ST6GALNAC1 35
  • 67.31 (n)
  • 64.27 (a)
  • 45 (a)
(Anolis carolinensis)
Reptilia ST6GALNAC1 36
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia st6galnac1 35
  • 55.68 (n)
  • 50.28 (a)
(Danio rerio)
Actinopterygii st6galnac1.1 35
  • 52.78 (n)
  • 47.85 (a)
st6galnac1.1 36
  • 40 (a)
st6galnac1.2 36
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4378 36
  • 21 (a)
Species with no ortholog for ST6GALNAC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST6GALNAC1 Gene

Gene Tree for ST6GALNAC1 (if available)
Gene Tree for ST6GALNAC1 (if available)

Paralogs for ST6GALNAC1 Gene

Paralogs for ST6GALNAC1 Gene

Selected SIMAP similar genes for ST6GALNAC1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ST6GALNAC1: view

Variants for ST6GALNAC1 Gene

Sequence variations from dbSNP and Humsavar for ST6GALNAC1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs717571 -- 76,624,741(-) ACTCC(A/C)TGGAT downstream-variant-500B
rs719430 -- 76,643,448(+) GGCTA(C/T)CATTT intron-variant
rs973631 -- 76,645,688(-) CTCAG(C/T)TTGCA upstream-variant-2KB
rs973632 -- 76,645,650(-) CCTGC(A/G)GAAGG upstream-variant-2KB
rs1034930 -- 76,636,590(-) tctcg(C/T)tttgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST6GALNAC1 Gene

Variant ID Type Subtype PubMed ID
nsv518385 CNV Gain 19592680
nsv820158 CNV Gain 19587683
esv2671702 CNV Deletion 23128226
esv2716257 CNV Deletion 23290073
esv269901 CNV Insertion 20981092

Relevant External Links for ST6GALNAC1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST6GALNAC1 Gene

Disorders for ST6GALNAC1 Gene

(2) Novoseek inferred disease relationships for ST6GALNAC1 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 33.5 7
colorectal cancer 28.3 1

Relevant External Links for ST6GALNAC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ST6GALNAC1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for ST6GALNAC1 Gene

Publications for ST6GALNAC1 Gene

  1. Cloning and expression of a human gene encoding an N- acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNac I); a candidate for synthesis of cancer-associated sialyl-Tnantigens. (PMID: 10536037) Ikehara Y. … Narimatsu H. (Glycobiology 1999) 3 4 23
  2. Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA. (PMID: 12820722) Julien S. … Delannoy P. (Glycoconj. J. 2001) 3 4 23
  3. The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human breast cancer. (PMID: 16319059) Sewell R. … Taylor-Papadimitriou J. (J. Biol. Chem. 2006) 3 23
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for ST6GALNAC1 Gene

Sources for ST6GALNAC1 Gene

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