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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ST6GAL2 Gene

protein-coding GIFtS: 54
GCID: GC02M107418

ST6 beta-galactosamide alpha-2,6-sialyltranferase 2

(Previous name: sialyltransferase 2 (monosialoganglioside sialyltransferase)...)
(Previous symbol: SIAT2)

Explore 5 diseases affiliated with
ST6GAL2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ST6 Beta-Galactosamide Alpha-2,6-Sialyltranferase 2¹ ²		St6gal2¹
SIAT2¹ ² ³		Beta-Galactoside Alpha-2,6-Sialyltransferase 2²
KIAA1877¹ ³ ⁵		Beta-Galactoside Alpha-2,6-Sialyltransferase II²
Sialyltransferase 2 (Monosialoganglioside Sialyltransferase)¹ ²		HST6Gal II³
Alpha 2,6-ST 2² ³		Sialyltransferase 2³
ST6GalII² ³		ST6Gal II³
CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,6-Sialyltransferase 2² ³		ST6GALII⁵
EC 2.4.99.1³ ⁸		EC 2.4.99⁸
St6GalII¹

External Ids:	HGNC: 10861¹	Entrez Gene: 84620²	Ensembl: ENSG00000144057⁷	OMIM: 608472⁵	UniProtKB: Q96JF0³

Export aliases for ST6GAL2 gene to outside databases

Previous GC identifers: GC02M106877 GC02M106789 GC02M101093

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ST6GAL2:

This locus encodes a sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid

from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone

response in schizophrenic patients. Alternatively spliced transcript variants have been described. (provided by

RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: SIAT2_HUMAN, Q96JF0

Function: Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor

substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc

sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins

and glycolipids

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022171.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ST6GAL2 gene promoter:
FOXO3 FOXO3a CUTL1 Nkx2-5 FOXO3b
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ST6GAL2 promoter sequence

Search SABiosciences Chromatin IP Primers for ST6GAL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST6GAL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2-q12.1 Ensembl cytogenetic band: 2q12.3 HGNC cytogenetic band: 2q11-q12

ST6GAL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST6GAL2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M107418: view genomic region (about GC identifiers)

Start:	107,418,056 bp from pter	End:	107,503,564 bp from pter
Size:	85,509 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SIAT2_HUMAN, Q96JF0 (See protein sequence)

Recommended Name: Beta-galactoside alpha-2,6-sialyltransferase 2

Size: 529 amino acids; 60158 Da

Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (By similarity)

Sequence caution: Sequence=AAH08680.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAB47506.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: D3DVK3 Q53QP4 Q86Y44 Q8IUG7 Q96HE4

Alternative splicing: 2 isoforms: Q96JF0-1 Q96JF0-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ST6GAL2: NX_Q96JF0

Post-translational modifications:

O-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96JF0

4/10 DME Specific Peptides for ST6GAL2 (Q96JF0) (see all 10)

GYEKDVG

RIINSQIL

HDAVLRFN

IQPNPPSSG

ST6GAL2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001135823.1 NP_001135824.1 NP_115917.1

ENSEMBL proteins:

ENSP00000355273 ENSP00000386942 ENSP00000355386 ENSP00000387332 ENSP00000395581

Human Recombinant Protein Products for ST6GAL2:

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	Uscn Proteins for ST6GAL2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	NAS	12235148
GO:0030173	integral to Golgi membrane	IEA	--
GO:0032580	Golgi cisterna membrane	IEA	--

ST6GAL2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ST6GAL2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ST6GAL2 for domains About GeneDecksing

2 InterPro domains/families:

IPR001675 Glyco_trans_29

IPR011330 Glyco_hydro/deAcase_b/a-brl

Graphical View of Domain Structure for InterPro Entry Q96JF0

ProtoNet protein and cluster: Q96JF0

1 Blocks protein family: IPB001675 Glycosyl transferase

UniProtKB/Swiss-Prot: SIAT2_HUMAN, Q96JF0

Similarity: Belongs to the glycosyltransferase 29 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SIAT2_HUMAN, Q96JF0

Function: Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor

substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc

sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins

and glycolipids

Catalytic activity: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP +

alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine

Biophysicochemical properties: Kinetic parameters: KM=0.74 mM for Gal-beta-1,4-GlcNAc-beta-O-octyl; KM=0.71 mM for

Gal-beta-1,4-GlcNAc; KM=0.48 mM for lacto-N-neotetraose;

Induction: By IL6/interleukin-6 and IL8//interleukin-8

Enzyme Numbers (IUBMB): EC 2.4.99.1¹ ² EC 2.4.99²

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003835	beta-galactoside alpha-2,6-sialyltransferase activity	IDA	12235148
GO:0008373	sialyltransferase activity	--	--

ST6GAL2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ST6GAL2:

Increased cell number in G1, s

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ST6GAL2

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		hsa-miR-579 hsa-miR-4254 hsa-miR-361-5p hsa-miR-300 hsa-miR-199a-3p hsa-miR-4305 hsa-miR-485-3p hsa-miR-149

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST6GAL2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Asparagine N-linked glycosylation

N-Glycan biosynthesis

0.52

Metabolism

Metabolic pathways

0.38

Glucuronidation

Other types of O-glycan biosynthesis

0.36

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Kegg Pathways (Kegg details for ST6GAL2):

	N-Glycan biosynthesis
	Other types of O-glycan biosynthesis
	Metabolic pathways

ST6GAL2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ST6GAL2

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for ST6GAL2 (ENSP00000355273⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
B4GALT1	ENSP00000369055⁴	STRING: ENSP00000369055
B4GALT2	ENSP00000349293⁴	STRING: ENSP00000349293
B4GALT3	ENSP00000320965⁴	STRING: ENSP00000320965

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006486	protein glycosylation	IEA	--
GO:0007275	multicellular organismal development	NAS	12235148
GO:0009311	oligosaccharide metabolic process	IDA	12235148
GO:0040007	growth	NAS	12235148

ST6GAL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ST6GAL2
Search CenterWatch for drugs/clinical trials and news about ST6GAL2 / SIAT2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ST6GAL2 gene (3 alternative transcripts):

NM_001142351.1 NM_001142352.1 NM_032528.2

Unigene Cluster for ST6GAL2:

ST6 beta-galactosamide alpha-2,6-sialyltranferase 2

Hs.98265 [show with all ESTs]

Unigene Representative Sequence: NM_032528

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000361686(uc002tdr.3) ENST00000409382(uc002tdq.3) ENST00000361803

ENST00000409087(uc002tds.3) ENST00000419159

miRNA Products:		OriGene 3'-UTR Clone (see all 3): ST6GAL2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST6GAL2
		8/76 QIAGEN miScript miRNA Assays for microRNAs that regulate ST6GAL2 (see all 76):
		hsa-miR-579 hsa-miR-4254 hsa-miR-361-5p hsa-miR-300 hsa-miR-199a-3p hsa-miR-4305 hsa-miR-485-3p hsa-miR-149

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AB058780.1 AB059555.1 AJ512141.1 AK055273.1 AK095049.1 AK095653.1 AK307784.1 BC008680.1

FJ433883.1 FJ433884.1 FJ433885.1

3 DOTS entries:

DT.40257355 DT.91665662 DT.120991405

13 AceView cDNA sequences:

BX327611 AX795201 AA385852 BE613250 AX795200 BC008680 BE612797 NM_032528

BF038052 AB059555 AX795199 AJ512141 BX353569

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ST6GAL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTCATTTG

About this image

ST6GAL2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ST6GAL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ST6GAL2

SOURCE GeneReport for Unigene cluster: Hs.98265

UniProtKB/Swiss-Prot: SIAT2_HUMAN, Q96JF0

Tissue specificity: Weakly expressed in some tissues, such as small intestine, colon and fetal brain

SABiosciences Custom PCR Arrays for ST6GAL2

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST6GAL2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ST6GAL2 gene from 5/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ST6GAL2¹	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	70.64(n) 72.12(a)		403122 NM_001167747.1 NP_001161219.1
lizard (Anolis carolinensis)	Reptilia	ST6GAL2⁶	--	70(a)	1 ↔ 1	3(108284002-108318334)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.17205²	Transcribed sequence with weak similarity to protein more	76.5(n)		BX764330.1
zebrafish (Danio rerio)	Actinopterygii	Dr.17176²	Transcribed sequence with weak similarity to protein more	74.73(n)		57092570
fruit fly (Drosophila melanogaster)	Insecta	ST6Gal⁶	Sialyltransferase	25(a)	1 → many	2R(20578945-20581909)

ENSEMBL Gene Tree for ST6GAL2 (if available)
TreeFam Gene Tree for ST6GAL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ST6GAL2 gene

ST6GALNAC3² ST6GAL1² ST6GALNAC5² ST6GALNAC4² ST6GALNAC6²

1 SIMAP similar gene for ST6GAL2 using alignment to 4 protein entries: SIAT2_HUMAN (see all proteins):

ST6GAL1

ST6GAL2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs17033290^1,2	C,F,H	--	101092776(+)	`CTTTAG/AGCTTT`	2	--	ds500¹		17	NA NS EA WA	1778
rs116365641^1,2	C,F	--	101093794(+)	`TCTCTC/TAAAAT`	2	--	ut3¹		1	WA	118
rs13408135^1,2	C,H	--	101094248(+)	`CAGTCA/GTGTAA`	2	--	ut3¹ ese³		4	NS EA	420
rs76687188^1,2		--	101094579(+)	`AAACGG/AGACCT`	2	--	ut3¹		1	WA	118
rs59437585^1,2	C	--	101094696(+)	`CCCAGC/TTACTT`	2	--	ut3¹		2	WA	120
rs114149388^1,2	C,F	--	101095780(+)	`GACTAC/TGACAA`	2	--	ut3¹		1	WA	118
rs17033292^1,2	C,F,H	--	101095791(+)	`AATTCC/TATTTA`	2	--	ut3¹		7	NA NS EA	562
rs73949758^1,2	C	--	101095802(+)	`AAAATC/ATTTAA`	2	--	ut3¹		1	WA	2
rs115513984^1,2	C,F	--	101096146(+)	`GCTCAC/TGCCTA`	2	--	ut3¹		1	NA	120
rs115296405^1,2	C,F	--	101096472(+)	`GTCTAT/CTTAGA`	2	--	ut3¹		1	WA	118

HapMap Linkage Disequilibrium report for ST6GAL2 (107418056 - 107503564 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ST6GAL2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ST6GAL2

DNA2.0 Custom Variant and Variant Library Synthesis for ST6GAL2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ST6GAL2 for disorders           About GeneDecksing

OMIM gene information: 608472    OMIM disorders: --

5 diseases for ST6GAL2:    About MalaCards

alpha 1-antitrypsin deficiency meningioma cerebritis schizophrenia

neuronitis

1 disease from the University of Copenhagen DISEASES database for ST6GAL2:

Alpha 1-antitrypsin deficiency

Human Genome Epidemiology (HuGE) Navigator: ST6GAL2 (4 documents)

Export disorders for ST6GAL2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ST6GAL2 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with ST6GAL2)

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Identification and functional expression of a second human beta- galactoside alpha2,6-sialyltransferase, ST6Gal II. (PubMed id 12603328)^{1, 2} Krzewinski-Recchi M.A....Delannoy P. (2003)
Characterization of the second type of human beta-galactoside alpha2,6-sialyltransferase (ST6Gal II) that sialylates Galbeta1,4GlcNAc structures on oligosaccharides preferentially. (PubMed id 12235148)^{1, 2} Takashima S.... Tsujimoto M. (2002)
Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)^{1, 2} Nagase T.... Ohara O. (2001)
LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. (PubMed id 23234360)² Halim A.... Nilsson J. (2013)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analy sis among pharmacogenomics, mouse expression, and genetic case-control associat ion approaches. (PubMed id 19850283)¹ Ikeda M....Iwata N. (2010)
Transcriptional regulation of the human ST6GAL2 gene in cerebral cortex and neuronal cells. (PubMed id 19768537)¹ Lehoux S....Krzewinski-Recchi M.A. (2010)
Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)¹ Flachsbart F....Nebel A. (2010)
Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)¹ Trynka G....Wijmenga C. (2009)
IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewis x epitopes in the human bronchial mucosa. (PubMed id 17944600)² Groux-Degroote S.... Delannoy P. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84620	HGNC: 10861	AceView: ST6GalII	Ensembl:ENSG00000144057	euGenes: HUgn84620
ECgene: ST6GAL2	Kegg: 84620	H-InvDB: ST6GAL2

(According to HUGE)
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HUGE: KIAA1877

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ST6GAL2	Pharmacogenomics, SNPs, Pathways
GGDB	http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST6GAL2

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Patent Information for ST6GAL2 gene:
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ST6GAL2 Gene

ST6 beta-galactosamide alpha-2,6-sialyltranferase 2

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ST6GAL2 Gene

ST6 beta-galactosamide alpha-2,6-sialyltranferase 2

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