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Aliases for ST6GAL2 Gene

Aliases for ST6GAL2 Gene

  • ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 2 2
  • ST6 Beta-Galactosamide Alpha-2,6-Sialyltranferase 2 2 3 5
  • CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,6-Sialyltransferase 2 3 4
  • Sialyltransferase 2 (Monosialoganglioside Sialyltransferase) 2 3
  • Alpha 2,6-ST 2 3 4
  • EC 2.4.99.1 4 63
  • ST6GalII 3 4
  • SIAT2 3 4
  • Beta-Galactoside Alpha-2,6-Sialyltransferase II 3
  • Sialyltransferase 2 4
  • Sialyltransferase 3
  • HST6Gal II 4
  • ST6Gal II 4
  • EC 2.4.99 63
  • KIAA1877 4

External Ids for ST6GAL2 Gene

Previous HGNC Symbols for ST6GAL2 Gene

  • SIAT2

Previous GeneCards Identifiers for ST6GAL2 Gene

  • GC02M106877
  • GC02M107418
  • GC02M101093

Summaries for ST6GAL2 Gene

Entrez Gene Summary for ST6GAL2 Gene

  • This locus encodes a sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone response in schizophrenic patients. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

GeneCards Summary for ST6GAL2 Gene

ST6GAL2 (ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include sialyltransferase activity and beta-galactoside alpha-2,6-sialyltransferase activity. An important paralog of this gene is ST6GALNAC4.

UniProtKB/Swiss-Prot for ST6GAL2 Gene

  • Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST6GAL2 Gene

Genomics for ST6GAL2 Gene

Regulatory Elements for ST6GAL2 Gene

Promoters for ST6GAL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ST6GAL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ST6GAL2 Gene

Chromosome:
2
Start:
106,794,128 bp from pter
End:
106,887,265 bp from pter
Size:
93,138 bases
Orientation:
Minus strand

Genomic View for ST6GAL2 Gene

Genes around ST6GAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST6GAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST6GAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST6GAL2 Gene

Proteins for ST6GAL2 Gene

  • Protein details for ST6GAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JF0-SIAT2_HUMAN
    Recommended name:
    Beta-galactoside alpha-2,6-sialyltransferase 2
    Protein Accession:
    Q96JF0
    Secondary Accessions:
    • D3DVK3
    • Q53QP4
    • Q86Y44
    • Q8IUG7
    • Q96HE4

    Protein attributes for ST6GAL2 Gene

    Size:
    529 amino acids
    Molecular mass:
    60158 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH08680.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB47506.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ST6GAL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ST6GAL2 Gene

Proteomics data for ST6GAL2 Gene at MOPED

Post-translational modifications for ST6GAL2 Gene

Other Protein References for ST6GAL2 Gene

Antibody Products

  • R&D Systems Antibodies for ST6GAL2 (ST6 Gal Sialyltransferase 2/ST6GAL2)

Domains & Families for ST6GAL2 Gene

Protein Domains for ST6GAL2 Gene

Suggested Antigen Peptide Sequences for ST6GAL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96JF0

UniProtKB/Swiss-Prot:

SIAT2_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST6GAL2: view

No data available for Gene Families for ST6GAL2 Gene

Function for ST6GAL2 Gene

Molecular function for ST6GAL2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.74 mM for Gal-beta-1,4-GlcNAc-beta-O-octyl {ECO:0000269 PubMed:12235148, ECO:0000269 PubMed:12603328}; KM=0.71 mM for Gal-beta-1,4-GlcNAc {ECO:0000269 PubMed:12235148, ECO:0000269 PubMed:12603328}; KM=0.48 mM for lacto-N-neotetraose {ECO:0000269 PubMed:12235148, ECO:0000269 PubMed:12603328};
UniProtKB/Swiss-Prot CatalyticActivity:
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine.
UniProtKB/Swiss-Prot Function:
Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.
UniProtKB/Swiss-Prot Induction:
By IL6/interleukin-6 and IL8//interleukin-8.

Enzyme Numbers (IUBMB) for ST6GAL2 Gene

Gene Ontology (GO) - Molecular Function for ST6GAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008373 sialyltransferase activity IEA --
genes like me logo Genes that share ontologies with ST6GAL2: view
genes like me logo Genes that share phenotypes with ST6GAL2: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ST6GAL2 Gene

Localization for ST6GAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST6GAL2 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST6GAL2 Gene COMPARTMENTS Subcellular localization image for ST6GAL2 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ST6GAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
genes like me logo Genes that share ontologies with ST6GAL2: view

Pathways & Interactions for ST6GAL2 Gene

genes like me logo Genes that share pathways with ST6GAL2: view

Interacting Proteins for ST6GAL2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000355273%0d%0a9606.ENSP00000310696%0d%0a9606.ENSP00000320965%0d%0a9606.ENSP00000358565%0d%0a9606.ENSP00000369055%0d%0a
Selected Interacting proteins: ENSP00000355273 for ST6GAL2 Gene via STRING

Gene Ontology (GO) - Biological Process for ST6GAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0018279 protein N-linked glycosylation via asparagine IBA,TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with ST6GAL2: view

No data available for SIGNOR curated interactions for ST6GAL2 Gene

Drugs & Compounds for ST6GAL2 Gene

(3) Additional Compounds for ST6GAL2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(N-acetylneuraminosyl(a2-6)lactosamine)
  • (N-acetylneuraminosyl(alpha2-6)lactosamine)
  • 6'-Sialyllactosamine
  • a-N-Acetylneuraminyl-2,6-b-D-galactosyl-1,4-N-acetyl-b-D-glucosamine
  • alpha-N-Acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
  • alpha-N-Acetylneuraminyl-2,6-beta-delta-galactosyl-1,4-N-acetyl-beta-delta-glucosamine
64364-50-7
Cytidine monophosphate
  • 5'-CMP
  • 5-Cytidylate
  • 5-Cytidylic acid
  • CMP
  • Cytidine 5'-monophosphate
63-37-6
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-Acetylneuraminate
  • CMP-N-Acylneuraminate
  • CMP-NeuNAc
  • Cytidine 5'-monophosphate N-acetylneuraminic acid
  • Cytidine Monophosphate N-Acetylneuraminate
22-12-8
genes like me logo Genes that share compounds with ST6GAL2: view

Transcripts for ST6GAL2 Gene

mRNA/cDNA for ST6GAL2 Gene

Unigene Clusters for ST6GAL2 Gene

ST6 beta-galactosamide alpha-2,6-sialyltranferase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ST6GAL2 Gene

No ASD Table

Relevant External Links for ST6GAL2 Gene

GeneLoc Exon Structure for
ST6GAL2
ECgene alternative splicing isoforms for
ST6GAL2

Expression for ST6GAL2 Gene

mRNA expression in normal human tissues for ST6GAL2 Gene

mRNA differential expression in normal tissues according to GTEx for ST6GAL2 Gene

This gene is overexpressed in Artery - Aorta (x11.5), Artery - Coronary (x8.0), and Thyroid (x4.9).

Protein differential expression in normal tissues from HIPED for ST6GAL2 Gene

This gene is overexpressed in Cerebrospinal fluid (59.2) and Fetal Brain (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ST6GAL2 Gene



SOURCE GeneReport for Unigene cluster for ST6GAL2 Gene Hs.98265

mRNA Expression by UniProt/SwissProt for ST6GAL2 Gene

Q96JF0-SIAT2_HUMAN
Tissue specificity: Weakly expressed in some tissues, such as small intestine, colon and fetal brain.
genes like me logo Genes that share expression patterns with ST6GAL2: view

Protein tissue co-expression partners for ST6GAL2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ST6GAL2 Gene

Orthologs for ST6GAL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST6GAL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ST6GAL2 35
  • 78.48 (n)
  • 77.8 (a)
ST6GAL2 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ST6GAL2 35
  • 83.23 (n)
  • 82.79 (a)
ST6GAL2 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St6gal2 35
  • 77.09 (n)
  • 75.63 (a)
St6gal2 16
St6gal2 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ST6GAL2 35
  • 99.05 (n)
  • 98.87 (a)
ST6GAL2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia St6gal2 35
  • 80.48 (n)
  • 81.27 (a)
oppossum
(Monodelphis domestica)
Mammalia ST6GAL2 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ST6GAL2 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves ST6GAL2 35
  • 70.64 (n)
  • 72.12 (a)
ST6GAL2 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST6GAL2 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st6gal2 35
  • 59.82 (n)
  • 61.64 (a)
Str.17205 35
zebrafish
(Danio rerio)
Actinopterygii Dr.17176 35
st6gal2a 35
  • 58.89 (n)
  • 57.2 (a)
st6gal2a 36
  • 54 (a)
OneToMany
st6gal2b 36
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ST6Gal 36
  • 28 (a)
OneToMany
Species with no ortholog for ST6GAL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST6GAL2 Gene

ENSEMBL:
Gene Tree for ST6GAL2 (if available)
TreeFam:
Gene Tree for ST6GAL2 (if available)

Paralogs for ST6GAL2 Gene

Paralogs for ST6GAL2 Gene

(1) SIMAP similar genes for ST6GAL2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ST6GAL2: view

Variants for ST6GAL2 Gene

Sequence variations from dbSNP and Humsavar for ST6GAL2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3796110 - 106,843,518(-) CCCCC(A/C/G/T)GGGAG nc-transcript-variant, reference, missense
rs12615112 - 106,834,069(+) GCGTA(C/T)GGTGG nc-transcript-variant, reference, missense
rs982913 -- 106,880,026(+) ACATA(C/T)CTAAT intron-variant
rs877693 -- 106,829,940(+) agaaa(C/T)acttc intron-variant
rs935565 -- 106,829,974(-) gttga(A/G)aatac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST6GAL2 Gene

Variant ID Type Subtype PubMed ID
esv2720482 CNV Deletion 23290073
nsv471617 CNV Gain 15918152
nsv874762 CNV Gain 21882294
esv2670283 CNV Deletion 23128226
esv2720492 CNV Deletion 23290073

Variation tolerance for ST6GAL2 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.31; 85.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ST6GAL2 Gene

HapMap Linkage Disequilibrium report
ST6GAL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST6GAL2 Gene

Disorders for ST6GAL2 Gene

Relevant External Links for ST6GAL2

Genetic Association Database (GAD)
ST6GAL2
Human Genome Epidemiology (HuGE) Navigator
ST6GAL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ST6GAL2

No disorders were found for ST6GAL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST6GAL2 Gene

Publications for ST6GAL2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  3. Transcriptional regulation of the human ST6GAL2 gene in cerebral cortex and neuronal cells. (PMID: 19768537) Lehoux S. … Krzewinski-Recchi M.A. (Glycoconj. J. 2010) 3
  4. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. (PMID: 19850283) Ikeda M. … Iwata N. (Biol. Psychiatry 2010) 3
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3

Products for ST6GAL2 Gene

Sources for ST6GAL2 Gene

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