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Aliases for ST6GAL2 Gene

Aliases for ST6GAL2 Gene

  • ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 2 2 3 5
  • CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,6-Sialyltransferase 2 3 4
  • Sialyltransferase 2 (Monosialoganglioside Sialyltransferase) 2 3
  • ST6 Beta-Galactosamide Alpha-2,6-Sialyltranferase 2 2 3
  • Alpha 2,6-ST 2 3 4
  • EC 2.4.99.1 4 61
  • ST6GalII 3 4
  • SIAT2 3 4
  • Beta-Galactoside Alpha-2,6-Sialyltransferase II 3
  • Beta-Galactoside Alpha-2,6-Sialyltransferase 2 3
  • Sialyltransferase 2 4
  • HST6Gal II 4
  • ST6Gal II 4
  • EC 2.4.99 61
  • KIAA1877 4

External Ids for ST6GAL2 Gene

Previous HGNC Symbols for ST6GAL2 Gene

  • SIAT2

Previous GeneCards Identifiers for ST6GAL2 Gene

  • GC02M106877
  • GC02M107418
  • GC02M101093

Summaries for ST6GAL2 Gene

Entrez Gene Summary for ST6GAL2 Gene

  • This locus encodes a sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone response in schizophrenic patients. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

GeneCards Summary for ST6GAL2 Gene

ST6GAL2 (ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 2) is a Protein Coding gene. Among its related pathways are Synthesis of substrates in N-glycan biosythesis and Transport to the Golgi and subsequent modification. GO annotations related to this gene include sialyltransferase activity and beta-galactoside alpha-2,6-sialyltransferase activity. An important paralog of this gene is ST6GAL1.

UniProtKB/Swiss-Prot for ST6GAL2 Gene

  • Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST6GAL2 Gene

Genomics for ST6GAL2 Gene

Regulatory Elements for ST6GAL2 Gene

Enhancers for ST6GAL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G106885 1.1 FANTOM5 ENCODE 18.3 +1.2 1242 1.6 CTCF MXI1 SUZ12 SIN3A RBBP5 CHD7 ZNF2 ZFHX2 POLR2A EZH2 ST6GAL2 ENSG00000227294
GH02G106839 0.8 ENCODE dbSUPER 11.4 +47.2 47226 0.2 CTCF JUND SMARCA4 CREB1 CREM RAD21 ST6GAL2 ENSG00000227294
GH02G106859 0.5 dbSUPER 16.6 +27.1 27092 1.4 CTCF MAFK ZNF507 ST6GAL2 ENSG00000227294
GH02G106840 0.4 dbSUPER 15.8 +43.8 43770 5.6 POLR2A SMARCA4 ST6GAL2 ENSG00000227294
GH02G106960 0.4 ENCODE 7.5 -73.9 -73912 2.0 EP300 ST6GAL2 ENSG00000226905 PPP1R2P5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ST6GAL2 on UCSC Golden Path with GeneCards custom track

Promoters for ST6GAL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000121305 365 1401 CTCF MXI1 SUZ12 TEAD4 SIN3A RBBP5 CHD7 ZNF2 RAD21 ZFHX2

Genomic Location for ST6GAL2 Gene

Chromosome:
2
Start:
106,794,128 bp from pter
End:
106,887,265 bp from pter
Size:
93,138 bases
Orientation:
Minus strand

Genomic View for ST6GAL2 Gene

Genes around ST6GAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST6GAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST6GAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST6GAL2 Gene

Proteins for ST6GAL2 Gene

  • Protein details for ST6GAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JF0-SIAT2_HUMAN
    Recommended name:
    Beta-galactoside alpha-2,6-sialyltransferase 2
    Protein Accession:
    Q96JF0
    Secondary Accessions:
    • D3DVK3
    • Q53QP4
    • Q86Y44
    • Q8IUG7
    • Q96HE4

    Protein attributes for ST6GAL2 Gene

    Size:
    529 amino acids
    Molecular mass:
    60158 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH08680.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB47506.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ST6GAL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ST6GAL2 Gene

Selected DME Specific Peptides for ST6GAL2 Gene

Q96JF0:
  • YYDAACTLGAYHPL
  • HDAVLRFN
  • EVHVYEYIPSVRQT
  • SMSRAFLYRLWKG
  • GYEKDVG
  • RIINSQIL
  • SAGAILNSSLG
  • WYKKPDYNLFTPY
  • QPFYILHPKFIWQLWDIIQENT
  • IQPNPPSSG

Post-translational modifications for ST6GAL2 Gene

Domains & Families for ST6GAL2 Gene

Gene Families for ST6GAL2 Gene

Protein Domains for ST6GAL2 Gene

Suggested Antigen Peptide Sequences for ST6GAL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96JF0

UniProtKB/Swiss-Prot:

SIAT2_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST6GAL2: view

Function for ST6GAL2 Gene

Molecular function for ST6GAL2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.74 mM for Gal-beta-1,4-GlcNAc-beta-O-octyl {ECO:0000269 PubMed:12235148, ECO:0000269 PubMed:12603328}; KM=0.71 mM for Gal-beta-1,4-GlcNAc {ECO:0000269 PubMed:12235148, ECO:0000269 PubMed:12603328}; KM=0.48 mM for lacto-N-neotetraose {ECO:0000269 PubMed:12235148, ECO:0000269 PubMed:12603328};
UniProtKB/Swiss-Prot CatalyticActivity:
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine.
UniProtKB/Swiss-Prot Function:
Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.
UniProtKB/Swiss-Prot Induction:
By IL6/interleukin-6 and IL8//interleukin-8.

Enzyme Numbers (IUBMB) for ST6GAL2 Gene

Gene Ontology (GO) - Molecular Function for ST6GAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity TAS --
GO:0008373 sialyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ST6GAL2: view
genes like me logo Genes that share phenotypes with ST6GAL2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ST6GAL2 Gene

Localization for ST6GAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST6GAL2 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST6GAL2 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ST6GAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,NAS 12235148
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with ST6GAL2: view

Pathways & Interactions for ST6GAL2 Gene

genes like me logo Genes that share pathways with ST6GAL2: view

Interacting Proteins for ST6GAL2 Gene

Gene Ontology (GO) - Biological Process for ST6GAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006486 protein glycosylation IEA --
GO:0007275 multicellular organism development NAS 12235148
GO:0009311 oligosaccharide metabolic process IDA 12235148
GO:0018279 protein N-linked glycosylation via asparagine IBA --
genes like me logo Genes that share ontologies with ST6GAL2: view

No data available for SIGNOR curated interactions for ST6GAL2 Gene

Drugs & Compounds for ST6GAL2 Gene

(1) Drugs for ST6GAL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine monophosphate Experimental Pharma 0

(2) Additional Compounds for ST6GAL2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(N-acetylneuraminosyl(a2-6)lactosamine)
  • (N-acetylneuraminosyl(alpha2-6)lactosamine)
  • 6'-Sialyllactosamine
  • a-N-Acetylneuraminyl-2,6-b-D-galactosyl-1,4-N-acetyl-b-D-glucosamine
  • alpha-N-Acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
  • alpha-N-Acetylneuraminyl-2,6-beta-delta-galactosyl-1,4-N-acetyl-beta-delta-glucosamine
64364-50-7
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-Acetylneuraminate
  • CMP-N-Acylneuraminate
  • CMP-NeuNAc
  • Cytidine 5'-monophosphate N-acetylneuraminic acid
  • Cytidine Monophosphate N-Acetylneuraminate
22-12-8
genes like me logo Genes that share compounds with ST6GAL2: view

Transcripts for ST6GAL2 Gene

Unigene Clusters for ST6GAL2 Gene

ST6 beta-galactosamide alpha-2,6-sialyltranferase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST6GAL2 Gene

No ASD Table

Relevant External Links for ST6GAL2 Gene

GeneLoc Exon Structure for
ST6GAL2
ECgene alternative splicing isoforms for
ST6GAL2

Expression for ST6GAL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST6GAL2 Gene

mRNA differential expression in normal tissues according to GTEx for ST6GAL2 Gene

This gene is overexpressed in Artery - Aorta (x11.5), Artery - Coronary (x8.0), and Thyroid (x4.9).

Protein differential expression in normal tissues from HIPED for ST6GAL2 Gene

This gene is overexpressed in Cerebrospinal fluid (59.2) and Fetal Brain (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ST6GAL2 Gene



Protein tissue co-expression partners for ST6GAL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ST6GAL2 Gene:

ST6GAL2

SOURCE GeneReport for Unigene cluster for ST6GAL2 Gene:

Hs.98265

mRNA Expression by UniProt/SwissProt for ST6GAL2 Gene:

Q96JF0-SIAT2_HUMAN
Tissue specificity: Weakly expressed in some tissues, such as small intestine, colon and fetal brain.

Evidence on tissue expression from TISSUES for ST6GAL2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ST6GAL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST6GAL2 Gene

Orthologs for ST6GAL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST6GAL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST6GAL2 34 35
  • 99.05 (n)
dog
(Canis familiaris)
Mammalia ST6GAL2 34 35
  • 83.23 (n)
rat
(Rattus norvegicus)
Mammalia St6gal2 34
  • 80.48 (n)
cow
(Bos Taurus)
Mammalia ST6GAL2 34 35
  • 78.48 (n)
mouse
(Mus musculus)
Mammalia St6gal2 34 16 35
  • 77.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ST6GAL2 35
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ST6GAL2 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ST6GAL2 34 35
  • 70.64 (n)
lizard
(Anolis carolinensis)
Reptilia ST6GAL2 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st6gal2 34
  • 59.82 (n)
Str.17205 34
zebrafish
(Danio rerio)
Actinopterygii st6gal2a 34 35
  • 58.89 (n)
st6gal2b 35
  • 52 (a)
OneToMany
Dr.17176 34
fruit fly
(Drosophila melanogaster)
Insecta ST6Gal 35
  • 28 (a)
OneToMany
Species where no ortholog for ST6GAL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST6GAL2 Gene

ENSEMBL:
Gene Tree for ST6GAL2 (if available)
TreeFam:
Gene Tree for ST6GAL2 (if available)

Paralogs for ST6GAL2 Gene

Paralogs for ST6GAL2 Gene

(1) SIMAP similar genes for ST6GAL2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ST6GAL2: view

Variants for ST6GAL2 Gene

Sequence variations from dbSNP and Humsavar for ST6GAL2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000001500 -- 106,824,741(+) ATACA(C/T)TACAT intron-variant, utr-variant-3-prime
rs1000061092 -- 106,808,161(+) ACCAG(A/C)GGAGT intron-variant
rs1000084355 -- 106,850,311(+) CTGCC(C/T)GCTGT intron-variant
rs1000134604 -- 106,861,162(+) GGGGA(A/G)GAAAA intron-variant
rs1000238362 -- 106,874,851(+) GACAA(A/G)CCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST6GAL2 Gene

Variant ID Type Subtype PubMed ID
dgv4034n100 CNV gain 25217958
dgv6988n54 CNV loss 21841781
esv2670283 CNV deletion 23128226
esv2720482 CNV deletion 23290073
esv2720492 CNV deletion 23290073
esv3591883 CNV loss 21293372
nsv1014939 CNV loss 25217958
nsv471617 CNV gain 15918152

Variation tolerance for ST6GAL2 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.31; 85.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ST6GAL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST6GAL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST6GAL2 Gene

Disorders for ST6GAL2 Gene

Relevant External Links for ST6GAL2

Genetic Association Database (GAD)
ST6GAL2
Human Genome Epidemiology (HuGE) Navigator
ST6GAL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ST6GAL2

No disorders were found for ST6GAL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST6GAL2 Gene

Publications for ST6GAL2 Gene

  1. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. (PMID: 19850283) Ikeda M. … Iwata N. (Biol. Psychiatry 2010) 3 46 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  5. Identification and functional expression of a second human beta- galactoside alpha2,6-sialyltransferase, ST6Gal II. (PMID: 12603328) Krzewinski-Recchi M.-A. … Delannoy P. (Eur. J. Biochem. 2003) 3 4 64

Products for ST6GAL2 Gene

Sources for ST6GAL2 Gene

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