Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ST6GAL2 Gene

protein-coding   GIFtS: 57
GCID: GC02M107418

ST6 Beta-Galactosamide Alpha-2,6-Sialyltranferase 2

(Previous name: sialyltransferase 2 (monosialoganglioside sialyltransferase))
(Previous symbol: SIAT2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
ST6 Beta-Galactosamide Alpha-2,6-Sialyltranferase 21 2     Beta-Galactoside Alpha-2,6-Sialyltransferase 22
SIAT21 2 3     Beta-Galactoside Alpha-2,6-Sialyltransferase II2
Sialyltransferase 2 (Monosialoganglioside Sialyltransferase)1 2     HST6Gal II3
Alpha 2,6-ST 22 3     Sialyltransferase 23
ST6GalII2 3     ST6Gal II3
CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,6-Sialyltransferase 22 3     ST6GALII5
EC 2.4.99.13 8     EC 2.4.998
KIAA18773 5     

External Ids:    HGNC: 108611   Entrez Gene: 846202   Ensembl: ENSG000001440577   OMIM: 6084725   UniProtKB: Q96JF03   

Export aliases for ST6GAL2 gene to outside databases

Previous GC identifers: GC02M106877 GC02M106789 GC02M101093


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ST6GAL2 Gene:
This locus encodes a sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic
acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in
risperidone response in schizophrenic patients. Alternatively spliced transcript variants have been described.
(provided by RefSeq, Jan 2012)

GeneCards Summary for ST6GAL2 Gene:
ST6GAL2 (ST6 beta-galactosamide alpha-2,6-sialyltranferase 2) is a protein-coding gene. Diseases associated with ST6GAL2 include alpha 1-antitrypsin deficiency, and meningioma. GO annotations related to this gene include beta-galactoside alpha-2,6-sialyltransferase activity. An important paralog of this gene is ST6GALNAC3.

UniProtKB/Swiss-Prot: SIAT2_HUMAN, Q96JF0
Function: Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor
substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc
sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward
glycoproteins and glycolipids




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ST6GAL2 gene promoter:
         FOXO3   FOXO3a   CUTL1   Nkx2-5   FOXO3b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidST6GAL2 promoter sequence
   Search Chromatin IP Primers for ST6GAL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST6GAL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2-q12.1   Ensembl cytogenetic band:  2q12.3   HGNC cytogenetic band: 2q11-q12

ST6GAL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST6GAL2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M107418:  view genomic region     (about GC identifiers)

Start:
107,418,056 bp from pter      End:
107,503,564 bp from pter
Size:
85,509 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SIAT2_HUMAN, Q96JF0 (See protein sequence)
Recommended Name: Beta-galactoside alpha-2,6-sialyltransferase 2  
Size: 529 amino acids; 60158 Da
Sequence caution: Sequence=AAH08680.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB47506.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: D3DVK3 Q53QP4 Q86Y44 Q8IUG7 Q96HE4
Alternative splicing: 2 isoforms:  Q96JF0-1   Q96JF0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ST6GAL2: NX_Q96JF0

Explore proteomics data for ST6GAL2 at MOPED

Post-translational modifications: 

  • O-glycosylated1
  • Glycosylation2 at Ser69, Ser102, Asn211, Ser523
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ST6GAL2 (Q96JF0) (see all 10)
     GYEKDVG  RIINSQIL  HDAVLRFN  IQPNPPSSG 


    See ST6GAL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001135823.1  NP_001135824.1  NP_115917.1  

    ENSEMBL proteins: 
     ENSP00000355273   ENSP00000386942   ENSP00000355386   ENSP00000387332   ENSP00000395581  
    Reactome Protein details: Q96JF0

    ST6GAL2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ST6GAL2
    GenScript Custom Purified and Recombinant Proteins Services for ST6GAL2
    Novus Biologicals ST6GAL2 Protein
    Novus Biologicals ST6GAL2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    ST6GAL2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for ST6GAL2 (ST6 Gal Sialyltransferase 2/ST6GAL2)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ST6GAL2
    Novus Biologicals ST6GAL2 Antibodies
    Search for Antibodies for ST6GAL2 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for ST6GAL2
    LSBio Antibodies in human, mouse, rat for ST6GAL2

    ST6GAL2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ST6GAL2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ST6GAL2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR001675 Glyco_trans_29
     IPR011330 Glyco_hydro/deAcase_b/a-brl

    Graphical View of Domain Structure for InterPro Entry Q96JF0

    ProtoNet protein and cluster: Q96JF0

    1 Blocks protein domain: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIAT2_HUMAN, Q96JF0
    Similarity: Belongs to the glycosyltransferase 29 family


    ST6GAL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIAT2_HUMAN, Q96JF0
    Function: Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor
    substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc
    sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward
    glycoproteins and glycolipids
    Catalytic activity: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP +
    alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
    Biophysicochemical properties: Kinetic parameters: KM=0.74 mM for Gal-beta-1,4-GlcNAc-beta-O-octyl; KM=0.71 mM for
    Gal-beta-1,4-GlcNAc; KM=0.48 mM for lacto-N-neotetraose;
    Induction: By IL6/interleukin-6 and IL8//interleukin-8

         Enzyme Numbers (IUBMB): EC 2.4.99.11 2 EC 2.4.992

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0003835beta-galactoside alpha-2,6-sialyltransferase activity IDA12235148
    GO:0008373sialyltransferase activity ----
         
    ST6GAL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ST6GAL2:
     Increased cell number in G1, s 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ST6GAL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ST6GAL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ST6GAL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ST6GAL2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ST6GAL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ST6GAL2 (see all 76):
    hsa-miR-579 hsa-miR-4254 hsa-miR-361-5p hsa-miR-300 hsa-miR-199a-3p hsa-miR-4305 hsa-miR-485-3p hsa-miR-149
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ST6GAL2
    Predesigned siRNA for gene silencing in human, mouse, rat ST6GAL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ST6GAL2

    Clone
    Products:
         
    OriGene clones in human, mouse for ST6GAL2 (see all 19)
    OriGene ORF clones in mouse, rat for ST6GAL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ST6GAL2 (NM_032528)
    Sino Biological Human cDNA Clone for ST6GAL2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST6GAL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST6GAL2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ST6GAL2
    Browse ESI BIO Cell Lines and PureStem Progenitors for ST6GAL2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST6GAL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SIAT2_HUMAN, Q96JF0: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular2
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane NAS12235148
    GO:0032580Golgi cisterna membrane IEA--

    ST6GAL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ST6GAL2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    N-Glycan biosynthesis0.49
    2Metabolism
    Metabolic pathways0.38
    3Other types of O-glycan biosynthesis
    Other types of O-glycan biosynthesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for ST6GAL2
        Sialic acid metabolism


    3 Kegg Pathways  (Kegg details for ST6GAL2):
        N-Glycan biosynthesis
    Other types of O-glycan biosynthesis
    Metabolic pathways


    ST6GAL2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ST6GAL2
    Interactions:

        Search GeneGlobe Interaction Network for ST6GAL2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ST6GAL2 (ENSP000003552734) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    B4GALT1ENSP000003690554STRING: ENSP00000369055
    B4GALT2ENSP000003492934STRING: ENSP00000349293
    B4GALT3ENSP000003209654STRING: ENSP00000320965
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006486protein glycosylation IEA--
    GO:0007275multicellular organismal development NAS12235148
    GO:0009311oligosaccharide metabolic process IDA12235148
    GO:0040007growth NAS12235148

    ST6GAL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ST6GAL2 (SIAT2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ST6GAL2 gene (3 alternative transcripts): 
    NM_001142351.1  NM_001142352.1  NM_032528.2  

    Unigene Cluster for ST6GAL2:

    ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
    Hs.98265  [show with all ESTs]
    Unigene Representative Sequence: NM_032528
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361686(uc002tdr.3) ENST00000409382(uc002tdq.3) ENST00000361803
    ENST00000409087(uc002tds.3) ENST00000419159
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ST6GAL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ST6GAL2 (see all 76):
    hsa-miR-579 hsa-miR-4254 hsa-miR-361-5p hsa-miR-300 hsa-miR-199a-3p hsa-miR-4305 hsa-miR-485-3p hsa-miR-149
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ST6GAL2
    Predesigned siRNA for gene silencing in human, mouse, rat ST6GAL2
    Clone
    Products:
         
    OriGene clones in human, mouse for ST6GAL2 (see all 19)
    OriGene ORF clones in mouse, rat for ST6GAL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ST6GAL2 (NM_032528)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST6GAL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST6GAL2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ST6GAL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ST6GAL2
      QuantiTect SYBR Green Assays in human, mouse, rat ST6GAL2
      QuantiFast Probe-based Assays in human, mouse, rat ST6GAL2

    Additional mRNA sequence: 

    AB058780.1 AB059555.1 AJ512141.1 AK055273.1 AK095049.1 AK095653.1 AK307784.1 BC008680.1 
    FJ433883.1 FJ433884.1 FJ433885.1 

    3 DOTS entries:

    DT.40257355  DT.91665662  DT.120991405 

    13 AceView cDNA sequences:

    BX327611 AX795200 BC008680 AX795201 BE613250 AA385852 BE612797 AX795199 
    BF038052 AB059555 NM_032528 BX353569 AJ512141 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ST6GAL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTCATTTG
    ST6GAL2 Expression
    About this image

    ST6GAL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ST6GAL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.98265

    UniProtKB/Swiss-Prot: SIAT2_HUMAN, Q96JF0
    Tissue specificity: Weakly expressed in some tissues, such as small intestine, colon and fetal brain

        Custom PCR Arrays for ST6GAL2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ST6GAL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ST6GAL2
    QuantiTect SYBR Green Assays in human, mouse, rat ST6GAL2
    QuantiFast Probe-based Assays in human, mouse, rat ST6GAL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST6GAL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ST6GAL2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St6gal21 , 5 beta galactoside alpha 2,6 sialyltransferase 21, 5 77.09(n)1
    75.63(a)1
      17 (28.82 cM)5
    2401191  NM_172829.21  NP_766417.11 
     554453825 
    chicken
    (Gallus gallus)
    Aves ST6GAL21 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 70.64(n)
    72.12(a)
      403122  NM_001167747.1  NP_001161219.1 
    lizard
    (Anolis carolinensis)
    Reptilia ST6GAL26
    Beta-galactoside alpha 2,6-sialyltransferase ST6Ga...
    70(a)
    1 ↔ 1
    3(108283945-108318334)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.172052 Transcribed sequence with weak similarity to protein more 76.5(n)    BX764330.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.171762 Transcribed sequence with weak similarity to protein more 74.73(n)    57092570 
    fruit fly
    (Drosophila melanogaster)
    Insecta ST6Gal6
    Sialyltransferase
    28(a)
    1 → many
    2R(20578945-20581909)


    ENSEMBL Gene Tree for ST6GAL2 (if available)
    TreeFam Gene Tree for ST6GAL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ST6GAL2 gene
    ST6GALNAC32  ST6GALNAC52  ST6GAL12  ST6GALNAC42  ST6GALNAC62  
    1 SIMAP similar gene for ST6GAL2 using alignment to 4 protein entries:     SIAT2_HUMAN (see all proteins):
    ST6GAL1

    ST6GAL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ST6GAL2 (see all 1849)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs130095161,2
    --101099199(+) ttattA/Cttttt 2 -- int1 trp30--------
    rs616761521,2
    C--101128563(+) AAAAA-/A/AA  
     AAAAAAA
    GAATT
    6 -- int1 cds11NA 2
    rs1460165291,2
    C--101175353(+) AAAAA-/ACTC  
            
    AATCA
    3 -- int10--------
    rs792980841,2
    C--101175354(+) AAAAA-/CTCA  
            
    ATCAA
    3 -- int10--------
    rs1116195161,2
    C--101175354(+) AAAAAA/CTCAAT 3 -- int10--------
    rs170332901,2
    C,F,H--107068460(+) CTTTAG/AGCTTT 2 -- ds500117Minor allele frequency- A:0.05NA NS EA WA 1778
    rs1411560301,2
    C--107068566(+) TTAAG-/TCAACA
            
    TCAAG
    2 -- ds50010--------
    rs1509186501,2
    C--107068598(+) ATATGC/GCTTTT 2 -- ds50010--------
    rs1408010151,2
    --107068616(+) ATTTCA/GCCACT 2 -- ds50010--------
    rs1905954371,2
    --107068677(+) ACCTGC/TGGTTT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for ST6GAL2 (107418056 - 107503564 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ST6GAL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670283CNV Deletion23128226
    esv2720482CNV Deletion23290073
    esv2720492CNV Deletion23290073
    nsv471617CNV Gain15918152
    nsv874762CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ST6GAL2
    DNA2.0 Custom Variant and Variant Library Synthesis for ST6GAL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608472    OMIM disorders: --

    5 diseases for ST6GAL2:    About MalaCards
    alpha 1-antitrypsin deficiency    meningioma    schizophrenia    cerebritis
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for ST6GAL2:
    Alpha 1-antitrypsin deficiency

    ST6GAL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ST6GAL2
    Human Genome Epidemiology (HuGE) Navigator: ST6GAL2 (4 documents)

    Export disorders for ST6GAL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ST6GAL2 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with ST6GAL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. (PubMed id 19850283)1, 4 Ikeda M....Iwata N. (Biol. Psychiatry 2010)
    3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    5. Identification and functional expression of a second human beta- galactoside alpha2,6-sialyltransferase, ST6Gal II. (PubMed id 12603328)1, 2 Krzewinski-Recchi M.-A.... Delannoy P. (Eur. J. Biochem. 2003)
    6. Characterization of the second type of human beta-galactoside alpha2,6-sialyltransferase (ST6Gal II) that sialylates Galbeta1,4GlcNAc structures on oligosaccharides preferentially. (PubMed id 12235148)1, 2 Takashima S.... Tsujimoto M. (J. Biol. Chem. 2002)
    7. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    8. LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. (PubMed id 23234360)2 Halim A.... Nilsson J. (J. Proteome Res. 2013)
    9. Transcriptional regulation of the human ST6GAL2 gene in cerebral cortex and neuronal cells. (PubMed id 19768537)1 Lehoux S....Krzewinski-Recchi M.A. (Glycoconj. J. 2010)
    10. IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewis x epitopes in the human bronchial mucosa. (PubMed id 17944600)2 Groux-Degroote S.... Delannoy P. (Biochem. J. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 84620 HGNC: 10861 AceView: ST6GalII Ensembl:ENSG00000144057 euGenes: HUgn84620
    ECgene: ST6GAL2 Kegg: 84620 H-InvDB: ST6GAL2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1877

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ST6GAL2 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST6GAL2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ST6GAL2 gene:
    Search GeneIP for patents involving ST6GAL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for ST6GAL2 (ST6 Gal Sialyltransferase 2/ST6GAL2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ST6GAL2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ST6GAL2  
     OriGene qSTAR qPCR primer pairs in human, mouse for ST6GAL2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ST6GAL2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ST6GAL2   OriGene Custom Protein Services for ST6GAL2  

     
     
     Block miRNA regulation of human, mouse, rat ST6GAL2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ST6GAL2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST6GAL2 Predesigned siRNA for gene silencing in human, mouse, rat ST6GAL2
     QuantiFast Probe-based Assays in human, mouse, rat ST6GAL2 QuantiTect SYBR Green Assays in human, mouse, rat ST6GAL2
     Custom PCR Arrays for ST6GAL2 Search Chromatin IP Primers for ST6GAL2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ST6GAL2  Search GeneGlobe Interaction Network for ST6GAL2
     Regulatory tfbs in ST6GAL2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ST6GAL2 GenScript cDNA clones with any tag delivered in your preferred vector for ST6GAL2
     GenScript Custom Assay Services for ST6GAL2 GenScript Custom overexpressing Cell Line Services for ST6GAL2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ST6GAL2 (SIAT2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ST6GAL2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ST6GAL2 antibodies
     ST6GAL2 proteins
     ST6GAL2 lysates
     Search for Antibodies for ST6GAL2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ST6GAL2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for ST6GAL2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST6GAL2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ST6GAL2
     SwitchGear Promoter luciferase reporter plasmids for ST6GAL2
     Search ThermoFisher Antibodies for ST6GAL2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST6GAL2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ST6GAL2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ST6GAL2
     LSBio Antibodies in human, mouse, rat for ST6GAL2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ST6GAL2 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4