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ST6GAL1 Gene

protein-coding   GIFtS: 63
GCID: GC03P186648

ST6 Beta-Galactosamide Alpha-2,6-Sialyltranferase 1

(Previous name: sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase))
(Previous symbol: SIAT1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ST6 Beta-Galactosamide Alpha-2,6-Sialyltranferase 11 2     EC 2.4.99.13 8
SIAT11 2 3 5     Sialyltransferase 1 (Beta-Galactoside Alpha-2,6-Sialytransferase)1
ST6Gal I1 2 3     ST6N2
Alpha 2,6-ST 12 3     Beta-Galactoside Alpha-2,6-Sialyltransferase 12
ST6GalI2 3     CMP-N-Acetylneuraminate Beta-Galactosamide Alpha-2,6-Sialyltransferase2
B-Cell Antigen CD752 3     Sialyltransferase 1 (Beta-Galactoside Alpha-2,6-Sialyltransferase)2
CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,6-Sialyltransferase 12 3     Sialyltransferase 13

External Ids:    HGNC: 108601   Entrez Gene: 64802   Ensembl: ENSG000000738497   OMIM: 1096755   UniProtKB: P159073   

Export aliases for ST6GAL1 gene to outside databases

Previous GC identifers: GC03P188132 GC03P184054


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ST6GAL1 Gene:
This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein
that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein,
which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the
generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This
gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have
been described. (provided by RefSeq, Aug 2009)

GeneCards Summary for ST6GAL1 Gene:
ST6GAL1 (ST6 beta-galactosamide alpha-2,6-sialyltranferase 1) is a protein-coding gene. Diseases associated with ST6GAL1 include drug-induced liver injury due to flucloxacillin, and bile duct carcinoma. GO annotations related to this gene include sialyltransferase activity and beta-galactoside alpha-2,6-sialyltransferase activity. An important paralog of this gene is ST6GALNAC3.

UniProtKB/Swiss-Prot: SIAT1_HUMAN, P15907
Function: Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates

Gene Wiki entry for ST6GAL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ST6GAL1 gene promoter:
         Max1   TBP   AML1a   TFIID   AP-4   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ST6GAL1 promoter sequence
   Search Chromatin IP Primers for ST6GAL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST6GAL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27-q28   Ensembl cytogenetic band:  3q27.3   HGNC cytogenetic band: 3q27-q28

ST6GAL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST6GAL1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P186648:  view genomic region     (about GC identifiers)

Start:
186,648,274 bp from pter      End:
186,796,341 bp from pter
Size:
148,068 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIAT1_HUMAN, P15907 (See protein sequence)
Recommended Name: Beta-galactoside alpha-2,6-sialyltransferase 1  
Size: 406 amino acids; 46605 Da
2 PDB 3D structures from and Proteopedia for ST6GAL1:
4JS1 (3D)        4JS2 (3D)    
Secondary accessions: A8KA14 D3DNV3

Explore the universe of human proteins at neXtProt for ST6GAL1: NX_P15907

Explore proteomics data for ST6GAL1 at MOPED

Post-translational modifications: 

  • The soluble form derives from the membrane form by proteolytic processing1
  • The HB-6, CDW75, and CD76 differentiation antigens are cell-surface carbohydrate determinants generated by this
    enzyme1
  • Glycosylation2 at Thr68, Asn149, Asn161
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for ST6GAL1 (P15907)
     HDAVLRFN  IQPNPPSSG 


    See ST6GAL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_003023.1  NP_775323.1  NP_775324.1  

    ENSEMBL proteins: 
     ENSP00000169298   ENSP00000397273   ENSP00000412821   ENSP00000400547   ENSP00000399525  
     ENSP00000407631   ENSP00000416163   ENSP00000390793   ENSP00000388928   ENSP00000389337  
     ENSP00000414504   ENSP00000411518   ENSP00000388789   ENSP00000415886   ENSP00000403063  
     ENSP00000412221  
    Reactome Protein details: P15907

    ST6GAL1 Human Recombinant Protein Products:

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    R&D Systems Recombinant & Natural Proteins for ST6GAL1 (ST6 Gal Sialyltransferase 1/ST6GAL1)
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    OriGene Purified Protein for ST6GAL1
    OriGene Protein Over-expression Lysate for ST6GAL1
    OriGene Custom MassSpec
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    Novus Biologicals ST6GAL1 Proteins
    Novus Biologicals ST6GAL1 Lysates
    Sino Biological Recombinant Protein for ST6GAL1
    Sino Biological Cell Lysate for ST6GAL1
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    ST6GAL1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for ST6GAL1 (ST6 Gal Sialyltransferase 1/ST6GAL1)
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    Novus Biologicals ST6GAL1 Antibodies
    Abcam antibodies for ST6GAL1
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    ThermoFisher Antibody for ST6GAL1
    LSBio Antibodies in human, mouse, rat for ST6GAL1

    ST6GAL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001675 Glyco_trans_29
     IPR012163 Sialyl_trans

    Graphical View of Domain Structure for InterPro Entry P15907

    ProtoNet protein and cluster: P15907

    1 Blocks protein domain: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIAT1_HUMAN, P15907
    Similarity: Belongs to the glycosyltransferase 29 family


    ST6GAL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIAT1_HUMAN, P15907
    Function: Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates
    Catalytic activity: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP +
    alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
    Enzyme regulation: Inhibited by CTP
    Biophysicochemical properties: Kinetic parameters: KM=530 uM for CMP-NeuAc; Vmax=1.074 pmol/min/ug enzyme;

         Enzyme Number (IUBMB): EC 2.4.99.11 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003835beta-galactoside alpha-2,6-sialyltransferase activity IDA--
    GO:0008373sialyltransferase activity IDA--
         
    ST6GAL1 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for St6gal1):
     digestive/alimentary  hematopoietic system  immune system  normal  other 

    ST6GAL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ST6GAL1: St6gal1tm1Jxm St6gal1tm1Jlau

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ST6GAL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ST6GAL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ST6GAL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ST6GAL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ST6GAL1:
    hsa-mir-21-5p (MIRT030941), hsa-mir-335-5p (MIRT017979), hsa-mir-18a-3p (MIRT040947)

    Block miRNA regulation of human, mouse, rat ST6GAL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ST6GAL1 (see all 30):
    hsa-miR-3130-5p hsa-miR-498 hsa-miR-3938 hsa-miR-125a-5p hsa-miR-4251 hsa-miR-1271 hsa-miR-3190 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidST6GAL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ST6GAL1
    Predesigned siRNA for gene silencing in human, mouse, rat ST6GAL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ST6GAL1

    Clone
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    OriGene clones in human, mouse for ST6GAL1 (see all 18)
    OriGene ORF clones in mouse, rat for ST6GAL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ST6GAL1 (NM_003032)
    Sino Biological Human cDNA Clone for ST6GAL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST6GAL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST6GAL1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ST6GAL1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST6GAL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIAT1_HUMAN, P15907: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted.
    Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus5
    cytosol3
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005576extracellular region IEA--
    GO:0005794Golgi apparatus ----
    GO:0016021integral component of membrane ----
    GO:0030173integral component of Golgi membrane IEA--

    ST6GAL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ST6GAL1 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Metabolism of proteins0.30
    N-Glycan biosynthesis0.49
    N-glycan antennae elongation in the medial/trans-Golgi0.00
    Post-translational protein modification0.43
    N-Glycan antennae elongation0.00
    Transport to the Golgi and subsequent modification0.40
    2O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.47
    Termination of O-glycan biosynthesis0.38
    3Metabolism
    Metabolic pathways0.38
    4Other types of O-glycan biosynthesis
    Other types of O-glycan biosynthesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3 Reactome Pathways for ST6GAL1
        Sialic acid metabolism
    N-Glycan antennae elongation
    Termination of O-glycan biosynthesis


    3 Kegg Pathways  (Kegg details for ST6GAL1):
        N-Glycan biosynthesis
    Other types of O-glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: SIAT1_HUMAN, P15907
    Pathway: Protein modification; protein glycosylation


    ST6GAL1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ST6GAL1: 

              Cell Surface Markers in human mouse rat
              Glycosylation in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ST6GAL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for ST6GAL1 (P159073 ENSP000001692984) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD22P202733, ENSP000000852194I2D: score=1 STRING: ENSP00000085219
    B4GALT1ENSP000003690554STRING: ENSP00000369055
    B4GALT2ENSP000003492934STRING: ENSP00000349293
    B4GALT3ENSP000003209654STRING: ENSP00000320965
    MUC19ENSP000003952534STRING: ENSP00000395253
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006054N-acetylneuraminate metabolic process IDA--
    GO:0006486protein glycosylation ----
    GO:0006959humoral immune response TAS7786324
    GO:0016266O-glycan processing TAS--
    GO:0018279protein N-linked glycosylation via asparagine TAS--

    ST6GAL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ST6GAL1 (SIAT1)

    4 HMDB Compounds for ST6GAL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    (N-acetylneuraminosyl(a2-6)lactosamine)alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine (see all 9)64364-50-7--
    Cytidine monophosphate5'-CMP (see all 14)63-37-6--
    Cytidine monophosphate N-acetylneuraminic acidCMP-N-acetylneuraminate (see all 6)22-12-8--
    N-AcetyllactosamineD-galactopyranosyl (see all 8)32181-59-2--

    10 Novoseek inferred chemical compound relationships for ST6GAL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sialic acid 73.4 13 10432010 (2), 9184831 (2), 19418726 (1), 11511814 (1) (see all 7)
    n-acetyllactosamine 68.3 5 16319516 (3), 14664380 (1), 9184831 (1)
    ganglioside 42.2 3 17478202 (1), 16053379 (1)
    polysaccharide 36.2 3 12429811 (1), 9147064 (1)
    glycolipid 27.3 2 10561117 (1), 12966079 (1)
    ribonucleic acid 19.4 2 12798701 (1), 11585423 (1)
    galactose 8.12 2 9838208 (1), 16897185 (1)
    oligonucleotide 3.22 5 17575688 (2), 17441333 (1)
    carbohydrates 1.37 1 15864429 (1)
    tyrosine 0 2 16782884 (1), 11559557 (1)



    ST6GAL1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ST6GAL1 gene (3 alternative transcripts): 
    NM_003032.2  NM_173216.2  NM_173217.2  

    Unigene Cluster for ST6GAL1:

    ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
    Hs.207459  [show with all ESTs]
    Unigene Representative Sequence: AK128726
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000169298(uc003frb.3) ENST00000463542 ENST00000487031 ENST00000455441
    ENST00000427315 ENST00000468614 ENST00000458216 ENST00000430309 ENST00000417392
    ENST00000438590 ENST00000448408 ENST00000485105 ENST00000440338 ENST00000448044(uc003frd.3)
    ENST00000416235 ENST00000423451 ENST00000446170 ENST00000448449
    miRNA
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    Block miRNA regulation of human, mouse, rat ST6GAL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ST6GAL1 (see all 30):
    hsa-miR-3130-5p hsa-miR-498 hsa-miR-3938 hsa-miR-125a-5p hsa-miR-4251 hsa-miR-1271 hsa-miR-3190 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidST6GAL1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ST6GAL1
    Predesigned siRNA for gene silencing in human, mouse, rat ST6GAL1
    Clone
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    OriGene clones in human, mouse for ST6GAL1 (see all 18)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ST6GAL1 (NM_003032)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST6GAL1
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ST6GAL1
      QuantiFast Probe-based Assays in human, mouse, rat ST6GAL1

    Additional mRNA sequence: 

    AF007133.1 AK128726.1 AK292879.1 AK312023.1 BC031476.1 BC040009.1 L11720.1 U67847.1 
    U67849.1 X17247.1 X54363.1 X62822.1 

    Selected DOTS entries (see all 27):

    DT.91751675  DT.100824958  DT.100723454  DT.95237166  DT.120840379  DT.95224058  DT.120840374  DT.434773 
    DT.91751673  DT.218310  DT.101980912  DT.120840315  DT.120840381  DT.120840396  DT.40213741  DT.91751669 
    DT.91751667  DT.92465385  DT.95120107  DT.95237150  DT.100824952  DT.101964761  DT.120840311  DT.120840393 

    Selected AceView cDNA sequences (see all 411):

    AK128726 NM_173217 BQ005989 AV650337 BM993420 BQ651134 AI432658 BU622722 
    AI678203 AA706401 CR619308 BM985099 BQ448699 CB161967 BG567341 AA931708 
    AA262158 AW849346 AI276413 AA017439 AA740663 CB241705 BF794465 AA969788 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ST6GAL1 (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^
    SP1:                          -     -     -                 -     -     -     -     -     -     -     -     -                                                   
    SP2:                                                                                                  -     -                                                   
    SP3:                                                                                                                                                            
    SP4:                          -     -     -                 -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -         
    SP5:                          -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -         

    ExUns: 16 ^ 17a · 17b · 17c · 17d ^ 18a · 18b · 18c ^ 19a · 19b
    SP1:  -     -                       -                           
    SP2:  -     -                       -                           
    SP3:        -                                                   
    SP4:  -     -                                                   
    SP5:  -     -                       -                           


    ECgene alternative splicing isoforms for ST6GAL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ST6GAL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACCCTCTC
    ST6GAL1 Expression
    About this image


    ST6GAL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Mature B-Cells Peripheral Blood
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    ST6GAL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ST6GAL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.207459
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ST6GAL1: 
              Cell Surface Markers in human mouse rat
              Glycosylation in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ST6GAL1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St6gal11 , 5 beta galactoside alpha 2,6 sialyltransferase 11, 5 82.46(n)1
    80.15(a)1
      16 (14.03 cM)5
    204401  NM_001252505.11  NP_001239434.11 
     232247405 
    chicken
    (Gallus gallus)
    Aves ST6GAL11 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 65.01(n)
    63.03(a)
      396169  NM_205241.1  NP_990572.1 
    lizard
    (Anolis carolinensis)
    Reptilia ST6GAL16
    ST6 beta-galactosamide alpha-2,6-sialyltranferase ...
    55(a)
    1 ↔ 1
    3(28590428-28614521)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia st6gal11 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 58.89(n)
    53.99(a)
      100491268  NM_001256287.1  NP_001243216.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CA471333.12   -- 73.63(n)    CA471333.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ST6Gal6
    Sialyltransferase
    25(a)
    1 → many
    2R(20578945-20581909)


    ENSEMBL Gene Tree for ST6GAL1 (if available)
    TreeFam Gene Tree for ST6GAL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ST6GAL1 gene
    ST6GALNAC32  ST6GAL22  ST6GALNAC52  ST6GALNAC42  ST6GALNAC62  
    1 SIMAP similar gene for ST6GAL1 using alignment to 16 protein entries:     SIAT1_HUMAN (see all proteins):
    ST6GAL2

    ST6GAL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ST6GAL1 (see all 3406)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1431642321,2
    --184142199(+) AAGGTC/GCAGAT 1 -- us2k10--------
    rs615415601,2
    C--186545833(+) AAAAA-/TTAAATAA 2 -- int11Minor allele frequency- TTA:0.00NA 2
    rs580851721,2
    C--186592148(+) TTTTT-/TTGAGAC 2 -- int11Minor allele frequency- TT:0.00NA 2
    rs361189721,2
    C,F--186646335(+) TTCCAC/TATGGC 2 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1147887331,2
    C,F--186646410(+) ATGGCG/AGCAGG 2 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1382135491,2
    --186646475(+) TGAGAC/GCTCCC 2 -- us2k10--------
    rs1440231031,2
    --186646482(+) TCCCTA/GTCACA 2 -- us2k10--------
    rs1467334261,2
    --186646522(+) GATCCA/GATCAC 2 -- us2k10--------
    rs1854168331,2
    --186646528(+) ATCACC/GTCCCA 2 -- us2k10--------
    rs1149852061,2
    C,F--186646602(+) GAGCCA/CAACCA 2 -- us2k11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for ST6GAL1 (186648274 - 186796341 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ST6GAL1 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726344CNV Deletion23290073
    esv2726345CNV Deletion23290073
    esv1371504CNV Deletion17803354
    esv2726343CNV Deletion23290073
    esv1985985CNV Deletion18987734
    nsv508975CNV Insertion20534489
    nsv519618CNV Loss19592680
    nsv4156CNV Loss18451855
    esv34136CNV Loss18971310
    nsv878072CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ST6GAL1
    DNA2.0 Custom Variant and Variant Library Synthesis for ST6GAL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 109675    OMIM disorders: --

    Selected diseases for ST6GAL1 (see all 31):    
    About MalaCards
    drug-induced liver injury due to flucloxacillin    bile duct carcinoma    colon adenocarcinoma    cervical squamous cell carcinoma
    cervical intraepithelial neoplasia    cervicitis    noma    influenza
    graves' disease    sinusitis    acute leukemia    labyrinthitis
    colorectal cancer    hepatocellular carcinoma    peritonitis    esophageal squamous cell carcinoma
    adenocarcinoma    cervical cancer    squamous cell carcinoma    cerebritis


    ST6GAL1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for ST6GAL1 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon adenocarcinoma 49.4 3 15930282 (2), 19014651 (1)
    colon cancer 34.7 10 9184831 (2), 11406350 (2), 19483716 (1), 7794269 (1) (see all 6)
    cervical carcinoma 27.5 5 17441333 (1), 17575688 (1)
    metastasis 15.3 3 15930282 (1), 16166423 (1), 19014651 (1)
    carcinoma 15.1 6 17355919 (1), 11585423 (1)
    tumors 6.03 27 16319516 (3), 16425369 (3), 19014651 (3), 12931020 (2) (see all 10)
    influenza 0.333 4 16081961 (2), 12857911 (2)
    carcinoma squamous cell 0 4 11585423 (2), 12798701 (1)
    cervical cancer 0 2 17575688 (1), 11585423 (1)
    breast cancer 0 2 12841680 (1), 9751611 (1)

    Genetic Association Database (GAD): ST6GAL1
    Human Genome Epidemiology (HuGE) Navigator: ST6GAL1 (2 documents)

    Export disorders for ST6GAL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ST6GAL1 gene, integrated from 10 sources (see all 146):
    (articles sorted by number of sources associating them with ST6GAL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete cDNA sequence encoding human beta-galactoside alpha-2,6- sialyltransferase. (PubMed id 2408023)1, 2, 3 Grundmann U.G.... Zettlmeissl G. (Nucleic Acids Res. 1990)
    2. The B cell antigen CD75 is a cell surface sialyltransferase. (PubMed id 2373995)1, 2, 9 Stamenkovic I.... Funderud S. (J. Exp. Med. 1990)
    3. The structure of human alpha-2,6-sialyltransferase reveals the binding mode of complex glycans. (PubMed id 23999306)1, 2 Kuhn B.... Rudolph M.G. (Acta Crystallogr. D 2013)
    4. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. (PubMed id 21874001)1, 4 Kooner J.S....Chambers J.C. (Nat. Genet. 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. (PubMed id 19483685)1, 4 Daly A.K.... . (Nat. Genet. 2009)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The HB-6, CDw75, and CD76 differentiation antigens are unique cell- surface carbohydrate determinants generated by the beta-galactoside alpha 2,6-sialyltransferase. (PubMed id 1730763)1, 2 Bast B.J.E.G.... Tedder T.F. (J. Cell Biol. 1992)
    10. Isolation and characterization of a partial cDNA for a human sialyltransferase. (PubMed id 2803295)1, 2 Lance P.... Lau J.T.Y. (Biochem. Biophys. Res. Commun. 1989)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6480 HGNC: 10860 AceView: SIAT1 Ensembl:ENSG00000073849 euGenes: HUgn6480
    ECgene: ST6GAL1 Kegg: 6480 H-InvDB: ST6GAL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ST6GAL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ST6GAL1 Genetics and Cytogenetics in Oncology and Haematology
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST6GAL1
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_628

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ST6GAL1 gene:
    Search GeneIP for patents involving ST6GAL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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