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Aliases & Descriptions for ST5
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases DENND2B 1 , 2 , 3 HTS1 1 , 2 , 3 , 5 MGC33090 2 p126 1 , 2
Descriptions DENN domain-containing protein 2B 3 DENN/MADD domain containing 2B 2 HeLa tumor suppression 1 3 suppression of tumorigenicity 5 2
Search outside databases for aliases for ST5 genePrevious GC identifers: GC11M009485 GC11M009161 GC11M008754 GC11M008679
Summaries for ST5 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for ST5 : This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice.The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain ofc-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability toreduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of thisgene encoding distinct isoforms are identified. [provided by RefSeq] UniProtKB/Swiss-Prot: ST5_HUMAN, P78524 Function : May be involved in cytoskeletal organization and tumorgenicity. Isoform 1 seems to beinvolved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 mayblock ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth
Gene Wiki entry for ST5
Genomic Location for ST5
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the ST5 gene Entrez Gene cytogenetic band: 11p15 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15 ST5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11M008671:
(about GC identifiers )
Start:
8,671,475 bp from pter
End:
8,889,074 bp from pter
Size:
217,600 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000011.8 NT_009237.17 Proteins for ST5
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
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Cell Signaling Technology ,
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Novus Biologicals )
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UniProtKB/Swiss-Prot: ST5_HUMAN, P78524 (See
protein sequence )Recommended Name: Suppression of tumorigenicity 5 Size : 1137 amino acids; 126499 Da
Subunit : Isoform 1 interacts with the SH3 domain of ABL1
Secondary accessions : B3KXQ6 P78523 Q16492 Q7KYY2 Q7KZ12 Q8NE12 Q9BQQ6Alternative promoter usage, Alternative splicing : 3 isoforms : P78524-1 P78524-2 P78524-3
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_005409.3 NP_631896.1 NP_998783.1 ENSEMBL proteins: ENSP00000299567 ENSP00000319678 ENSP00000350294 ENSP00000379900 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells Antibodies for ST5: Assays for ST5:
Protein
Domains/ Families for ST5(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P78524 ProtoNet protein and cluster: P78524
UniProtKB/Swiss-Prot: ST5_HUMAN, P78524 Similarity : Contains 1 dDENN domainSimilarity : Contains 1 DENN domainSimilarity : Contains 1 uDENN domain
Gene Function for ST5
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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RNAi Products ,
Clones , and
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Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_139157 Applied Biosystems Silencer ® siRNAs for ST5 Sigma-Aldrich siRNA for ST5 Sigma-Aldrich shRNA Panels and shRNA for ST5 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_005418                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_005418                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_005418  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005418 UniProtKB/Swiss-Prot: ST5_HUMAN, P78524 Function : May be involved in cytoskeletal organization and tumorgenicity. Isoform 1 seems to beinvolved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 mayblock ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth
1 Gene Ontology (GO) molecular function term (links to tree view) :
About this table
Pathways & Interactions for ST5
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for ST5 5/15 Interacting proteins for ST5 (ENSP00000350294 3 P78524 1 , 2 ) via UniProtKB, MINT, and/or STRING (see all 15
)About this table
Drugs & Compounds for ST5 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for ST5
Transcripts for ST5(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_139157 Sigma-Aldrich siRNA for ST5 Sigma-Aldrich shRNA Panels and shRNA for ST5 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_005418 NM_139157 NM_213618
REFSEQ mRNAs for ST5 gene (3 alternative transcripts): NM_005418.3 NM_139157.2 NM_213618.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005418 NM_139157 NM_213618
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_005418                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_005418                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_005418  
Additional cDNA sequence: AK123380.1 AK126554.1 AK127763.1 AK293245.1 AK302824.1 AK307617.1 AK309929.1 AK312305.1 AK312758.1 BC036655.1 BX647431.1 BX647474.1 CR611680.1 S45936.1 U15131.1 U15779.1 U15780.1
24/38 DOTS entries (see all 38
): DT.91832935 DT.100785453 DT.101981184 DT.455736 DT.92438514 DT.100785460 DT.75188964 DT.100785456 DT.120726121 DT.99977160 DT.95148226 DT.120726016 DT.120726172 DT.97795613 DT.95148234 DT.100785461 DT.92039293 DT.120726144 DT.120726150 DT.100739170 DT.86853926 DT.92438516 DT.100785458 DT.120725943
24/301 AceView cDNA sequences (see all 301
):BU528932 CB529540 BU155307 AI269509 AA399294 BU070318 BM823967 BQ720478 CF454471 AI270279 AW082200 BU170512 BM716690 AL043546 BE048030 BF724958 BU783990 BE045970 BM972253 CR611680 BU193497 NM_213618 BX472075 CA441929
highest scoring ESTs for ST5 :AK126554 U15131 U15780 BC036655 BG773425 AA029062 AA029166 AA044178 AA044363 AA131596
Unigene Cluster for ST5: Suppression of tumorigenicity 5 Hs.117715 [show with all ESTs ] Unigene Representative Sequence: NM_005418 GeneLoc Exon Structure 5/30 Alternative Splicing Database (ASD) splice patterns (SP) for ST5 (see all 30
) ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d · 14e · 14f · 14g · SP1 :   -   -   -   -     -   -   -   -   -   -   -   -   -   -   -   -                   SP2 :                         -   -   -   -   -   -                   SP3 :             -   -   -   -   -   -   -   -   -   -   -   -     -   -   -   -   -   -   -   SP4 :                                                     SP5 :                                                    
ExUns: 14h · 14i · 14j ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ SP1 :                 -   -   -                       -     -       SP2 :                 -   -   -                       -     -       SP3 : -   -   -   -   -   -       -   -   -                       -     -       SP4 :                   -   -                       -     -       SP5 :                                                    
ExUns: 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35a · 35b · 35c ^ 36 ^ 37a · 37b SP1 :     -       -     -   -                 SP2 :     -       -     -   -                 SP3 :     -       -     -   -                 SP4 :     -       -     -   -                 SP5 :           -     -   -                
About this scheme ECgene alternative splicing isoforms for ST5 4 Ensembl transcripts including schematic representations : ENST00000353815
ENST00000313726
ENST00000357665
ENST00000396665
Expression for ST5
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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ST5 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for ST5 1 / 2 / 3
4 probe-sets matching ST5 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GGAAGCCCACSOURCE GeneReport for Unigene cluster: Hs.117715 Expression variation in blood from EXPOLDB for ST5
UniProtKB/Swiss-Prot: ST5_HUMAN, P78524 Tissue specificity : Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoidcell lines (at protein level). Isoform 3 is expressed in primary cell or weakly tumorigenic butnot in tumorigenic cell lines (at protein level)
Orthologs for ST5
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for ST5 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for ST5 ENSEMBL Gene Tree for ST5 Paralogs for ST5 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for ST5 gene DENND2D 2 DENND2A 2 DENND2C 2
SNPs/Variants for ST5 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for ST5 (up to first 250kb)
Disorders & Mutations for ST5
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 140750
Medical News for ST5 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for ST5 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/13 PubMed articles for ST5 gene (see all 13
): Identification of a human chromosome 11 gene which is differentially regulated in tumorigenic and nontumorigenic somatic cell hybrids of HeLa cells. (PubMed id 1390339) 2, 3, 4 Lichy J.H.... Howley P.M. (1992) Activation of extracellular signal-regulated kinase 2 by a novel Abl- binding protein, ST5. (PubMed id 9632734) 1, 3, 4 Majidi M.... Lichy J.H. (1998) Differential expression of the human ST5 gene in HeLa-fibroblast hybrid cell lines mediated by YY1: evidence that YY1 plays a part in tumor suppression. (PubMed id 8972856) 1, 3, 4 Lichy J.H.... Tsai M.M. (1996) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 3, 4 Olsen J.V....Mann M. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. (PubMed id 11528127) 3, 4 Amid C....Schmidt E.R. (2001) Expression of an isoform of the novel signal transduction protein ST5 is linked to cell morphology. (PubMed id 10229203) 3, 4 Hubbs A.E.... Lichy J.H. (1999) Deletion of the COOH terminus converts the ST5 p70 protein from an inhibitor of RAS signaling to an activator with transforming activity in NIH-3T3 cells. (PubMed id 10692462) 1, 3 Majidi M....Lichy J.H. (2000) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 4 Dephoure N.... Gygi S.P. (2008) Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. (PubMed id 15778465) 3 Benzinger A.... Hermeking H. (2005)
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Genome Databases showing ST5
(According to
Entrez Gene ,
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Specialized Databases showing ST5 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for ST5 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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