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Aliases for ST5 Gene

Aliases for ST5 Gene

  • Suppression Of Tumorigenicity 5 2 3
  • HTS1 3 4 6
  • DENN/MADD Domain Containing 2B 2 3
  • HeLa Tumor Suppression 1 3 4
  • DENND2B 3 4
  • Suppression Of Tumorigenicity 5 Protein 3
  • DENN Domain-Containing Protein 2B 4
  • P126 3

External Ids for ST5 Gene

Previous GeneCards Identifiers for ST5 Gene

  • GC11M009485
  • GC11M009161
  • GC11M008754
  • GC11M008679
  • GC11M008671
  • GC11M008382

Summaries for ST5 Gene

Entrez Gene Summary for ST5 Gene

  • This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST5 Gene

ST5 (Suppression Of Tumorigenicity 5) is a Protein Coding gene. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND2C.

UniProtKB/Swiss-Prot for ST5 Gene

  • Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth.

Gene Wiki entry for ST5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST5 Gene

Genomics for ST5 Gene

Regulatory Elements for ST5 Gene

Genomic Location for ST5 Gene

Start:
8,693,351 bp from pter
End:
8,910,951 bp from pter
Size:
217,601 bases
Orientation:
Minus strand

Genomic View for ST5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ST5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST5 Gene

Proteins for ST5 Gene

  • Protein details for ST5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78524-ST5_HUMAN
    Recommended name:
    Suppression of tumorigenicity 5 protein
    Protein Accession:
    P78524
    Secondary Accessions:
    • B2R6X7
    • B3KXQ6
    • P78523
    • Q16492
    • Q7KYY2
    • Q7KZ12
    • Q8NE12
    • Q9BQQ6

    Protein attributes for ST5 Gene

    Size:
    1137 amino acids
    Molecular mass:
    126485 Da
    Quaternary structure:
    • Isoform 1 interacts with the SH3 domain of ABL1.
    SequenceCaution:
    • Sequence=AAC50925.1; Type=Frameshift; Positions=159, 169; Evidence={ECO:0000305};

    Alternative splice isoforms for ST5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ST5 Gene

Proteomics data for ST5 Gene at MOPED

Post-translational modifications for ST5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ST5 Gene

Domains for ST5 Gene

Gene Families for ST5 Gene

HGNC:
  • DENND :DENN/MADD domain containing

Protein Domains for ST5 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P78524

UniProtKB/Swiss-Prot:

ST5_HUMAN :
  • P78524
Domain:
  • Contains 1 dDENN domain.
  • Contains 1 DENN domain.
  • Contains 1 uDENN domain.
genes like me logo Genes that share domains with ST5: view

Function for ST5 Gene

Molecular function for ST5 Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth.

Gene Ontology (GO) - Molecular Function for ST5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017112 Rab guanyl-nucleotide exchange factor activity IDA 20937701
genes like me logo Genes that share ontologies with ST5: view

miRNA for ST5 Gene

miRTarBase miRNAs that target ST5

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ST5 Gene

Localization for ST5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST5 Gene COMPARTMENTS Subcellular localization image for ST5 gene
Compartment Confidence
nucleus 3
cytosol 1
extracellular 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ST5 Gene

Pathways for ST5 Gene

SuperPathways for ST5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ST5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
GO:0070374 positive regulation of ERK1 and ERK2 cascade IDA 9632734
genes like me logo Genes that share ontologies with ST5: view

No data available for Pathways by source for ST5 Gene

Transcripts for ST5 Gene

Unigene Clusters for ST5 Gene

Suppression of tumorigenicity 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ST5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d · 14e · 14f · 14g ·
SP1: - - - - - - - - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - - - - - - - -
SP4:
SP5:
SP6: - - - - - - - - - - - - -
SP7:
SP8:
SP9:
SP10:
SP11: - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14:
SP15:
SP16:
SP17: - - - - - - - - - - - -
SP18: - - - - - - - - - - - - - -
SP19: - - - - - - - - - - - - - -
SP20: - - - - - - - -
SP21: - - - - - - - - - - - - - - - - -
SP22: - - - - - - -
SP23: - - - - -
SP24: - - - - - - - - - - - - - - -
SP25: - - - -
SP26: - -
SP27: -
SP28:
SP29:
SP30: - - - - - - -

ExUns: 14h · 14i · 14j ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - - - - -
SP4: - - - -
SP5:
SP6: - - - - - - - - -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - - - - - - - -
SP14: - - - - - - -
SP15: -
SP16: -
SP17:
SP18: - - - - - - - - -
SP19:
SP20: - - -
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:

ExUns: 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35a · 35b · 35c ^ 36 ^ 37a · 37b
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6:
SP7:
SP8:
SP9: - -
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:

Relevant External Links for ST5 Gene

GeneLoc Exon Structure for
ST5
ECgene alternative splicing isoforms for
ST5

Expression for ST5 Gene

mRNA expression in normal human tissues for ST5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ST5 Gene

SOURCE GeneReport for Unigene cluster for ST5 Gene Hs.117715

mRNA Expression by UniProt/SwissProt for ST5 Gene

P78524-ST5_HUMAN
Tissue specificity: Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level). Isoform 3 is expressed in primary cell or weakly tumorigenic but not in tumorigenic cell lines (at protein level).
genes like me logo Genes that share expressions with ST5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ST5 Gene

Orthologs for ST5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST5 35
  • 99.6 (n)
  • 99.54 (a)
ST5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ST5 35
  • 92.17 (n)
  • 93.84 (a)
ST5 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ST5 35
  • 92.84 (n)
  • 94.96 (a)
ST5 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St5 35
  • 89.95 (n)
  • 93.3 (a)
St5 16
St5 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ST5 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ST5 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia St5 35
  • 89.03 (n)
  • 91.91 (a)
chicken
(Gallus gallus)
Aves ST5 35
  • 74.46 (n)
  • 81.72 (a)
ST5 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST5 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1916 35
tropical clawed frog
(Silurana tropicalis)
Amphibia st5 35
  • 72.2 (n)
  • 75.69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8836 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16306 35
st5 35
  • 67.53 (n)
  • 70.52 (a)
st5 36
  • 65 (a)
OneToOne
Species with no ortholog for ST5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST5 Gene

ENSEMBL:
Gene Tree for ST5 (if available)
TreeFam:
Gene Tree for ST5 (if available)

Paralogs for ST5 Gene

genes like me logo Genes that share paralogs with ST5: view

Variants for ST5 Gene

Sequence variations from dbSNP and Humsavar for ST5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs871676 -- 8,716,985(+) CAAAG(C/G)CAGAA intron-variant
rs871677 -- 8,717,296(+) GGACC(C/T)ACACC intron-variant
rs884188 -- 8,715,934(+) GCCAT(C/G)TTGCC intron-variant
rs891787 -- 8,882,384(-) TGAAG(C/T)GAGCC intron-variant
rs905289 -- 8,732,005(+) ATCTC(A/G)CTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST5 Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241
nsv7664 CNV Insertion 18451855
essv24306 CNV CNV 17122850
nsv527920 CNV Loss 19592680
nsv509388 CNV Insertion 20534489
nsv527073 CNV Loss 19592680
nsv7665 CNV Insertion 18451855
nsv435923 CNV Deletion 17901297
nsv513308 CNV Insertion 21212237
nsv832062 CNV Loss 17160897
esv2669920 CNV Deletion 23128226
esv271927 CNV Insertion 20981092
esv273960 CNV Insertion 20981092
nsv7666 CNV Insertion 18451855
esv2744087 CNV Deletion 23290073
esv2744088 CNV Deletion 23290073
esv2744089 CNV Deletion 23290073
esv1699885 CNV Deletion 17803354

Relevant External Links for ST5 Gene

HapMap Linkage Disequilibrium report
ST5
Human Gene Mutation Database (HGMD)
ST5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST5 Gene

Disorders for ST5 Gene

(2) University of Copenhagen DISEASES for ST5 Gene

Relevant External Links for ST5

Genetic Association Database (GAD)
ST5
Human Genome Epidemiology (HuGE) Navigator
ST5
genes like me logo Genes that share disorders with ST5: view

No data available for UniProtKB/Swiss-Prot for ST5 Gene

Publications for ST5 Gene

  1. Identification of a human chromosome 11 gene which is differentially regulated in tumorigenic and nontumorigenic somatic cell hybrids of HeLa cells. (PMID: 1390339) Lichy J.H. … Howley P.M. (Cell Growth Differ. 1992) 2 3 4
  2. Differential expression of the human ST5 gene in HeLa-fibroblast hybrid cell lines mediated by YY1: evidence that YY1 plays a part in tumor suppression. (PMID: 8972856) Lichy J.H. … Tsai M.M. (Nucleic Acids Res. 1996) 3 4 23
  3. Activation of extracellular signal-regulated kinase 2 by a novel Abl- binding protein, ST5. (PMID: 9632734) Majidi M. … Lichy J.H. (J. Biol. Chem. 1998) 3 4 23
  4. Deletion of the COOH terminus converts the ST5 p70 protein from an inhibitor of RAS signaling to an activator with transforming activity in NIH-3T3 cells. (PMID: 10692462) Majidi M. … Lichy J.H. (J. Biol. Chem. 2000) 3 23
  5. Expression of an isoform of the novel signal transduction protein ST5 is linked to cell morphology. (PMID: 10229203) Hubbs A.E. … Lichy J.H. (Oncogene 1999) 3 4

Products for ST5 Gene

Sources for ST5 Gene

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