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ST5 Gene

protein-coding   GIFtS: 55
GCID: GC11M008714

Suppression Of Tumorigenicity 5

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Suppression Of Tumorigenicity 51 2     DENND2B2 3
HTS12 3 5     p1262
DENN/MADD Domain Containing 2B1 2     Suppression Of Tumorigenicity 5 Protein2
HeLa Tumor Suppression 12 3     DENN Domain-Containing Protein 2B3

External Ids:    HGNC: 113501   Entrez Gene: 67642   Ensembl: ENSG000001664447   OMIM: 1407505   UniProtKB: P785243   

Export aliases for ST5 gene to outside databases

Previous GC identifers: GC11M009485 GC11M009161 GC11M008754 GC11M008679 GC11M008671 GC11M008382


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ST5 Gene:
This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein
encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP
binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of
MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three
alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ST5 Gene:
ST5 (suppression of tumorigenicity 5) is a protein-coding gene. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND5A.

UniProtKB/Swiss-Prot: ST5_HUMAN, P78524
Function: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of
GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May be involved in
cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway
leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter
cell morphology and cell growth

Gene Wiki entry for ST5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ST5 gene promoter:
         ATF-2   c-Jun   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): ST5 promoter sequence
   Search Chromatin IP Primers for ST5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15

ST5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M008714:  view genomic region     (about GC identifiers)

Start:
8,714,898 bp from pter      End:
8,932,498 bp from pter
Size:
217,601 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ST5_HUMAN, P78524 (See protein sequence)
Recommended Name: Suppression of tumorigenicity 5 protein  
Size: 1137 amino acids; 126485 Da
Subunit: Isoform 1 interacts with the SH3 domain of ABL1
Sequence caution: Sequence=AAC50925.1; Type=Frameshift; Positions=159, 169;
Secondary accessions: B2R6X7 B3KXQ6 P78523 Q16492 Q7KYY2 Q7KZ12 Q8NE12 Q9BQQ6
Alternative promoter usage, Alternative splicing: 3 isoforms:  P78524-1   P78524-2   P78524-3   (Produced by alternative promoter usage)

Explore the universe of human proteins at neXtProt for ST5: NX_P78524

Explore proteomics data for ST5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ST5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_005409.3  NP_631896.1  NP_998783.1  

    ENSEMBL proteins: 
     ENSP00000435097   ENSP00000433528   ENSP00000319678   ENSP00000432887   ENSP00000436808  
     ENSP00000435986   ENSP00000433349   ENSP00000436802   ENSP00000433043   ENSP00000436067  
     ENSP00000433588   ENSP00000435016   ENSP00000433793   ENSP00000437096   ENSP00000431580  
     ENSP00000433858   ENSP00000437006   ENSP00000431564   ENSP00000434701   ENSP00000432521  
     ENSP00000436506   ENSP00000435292   ENSP00000436760   ENSP00000433647   ENSP00000431252  
     ENSP00000434935   ENSP00000433346   ENSP00000433008   ENSP00000431332   ENSP00000431139  
     ENSP00000432872   ENSP00000431673   ENSP00000434332   ENSP00000431990   ENSP00000435228  
     ENSP00000436748   ENSP00000434930   ENSP00000435925   ENSP00000435180   ENSP00000435562  
     ENSP00000433175   ENSP00000436363   ENSP00000436154   ENSP00000350294  

    ST5 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ST5

     
    Search eBioscience for Proteins for ST5 

     
    antibodies-online proteins for ST5 (2 products) 

     
    antibodies-online peptides for ST5

    ST5 Antibody Products:

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    antibodies-online antibodies for ST5 (44 products) 

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    antibodies-online kits for ST5 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DENND: DENN/MADD domain containing

    3 InterPro protein domains:
     IPR005112 dDENN_dom
     IPR005113 uDENN_dom
     IPR001194 DENN_dom

    Graphical View of Domain Structure for InterPro Entry P78524

    ProtoNet protein and cluster: P78524

    UniProtKB/Swiss-Prot: ST5_HUMAN, P78524
    Similarity: Contains 1 dDENN domain
    Similarity: Contains 1 DENN domain
    Similarity: Contains 1 uDENN domain


    Find genes that share domains with ST5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST5_HUMAN, P78524
    Function: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of
    GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May be involved in
    cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway
    leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter
    cell morphology and cell growth

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017112Rab guanyl-nucleotide exchange factor activity IDA--
         
    Find genes that share ontologies with ST5           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ST5

    miRNA
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    miRTarBase miRNAs that target ST5:
    hsa-mir-98-5p (MIRT027459)

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    Selected qRT-PCR Assays for microRNAs that regulate ST5 (see all 23):
    hsa-miR-194* hsa-miR-140-5p hsa-miR-146b-3p hsa-miR-300 hsa-miR-520d-5p hsa-miR-486-5p hsa-miR-124 hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmidST5 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: ST5 (NM_001900)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    extracellular1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ST5
    Interactions:

        GeneGlobe Interaction Network for ST5

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for ST5 (P785242, 3 ENSP000003196784) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157962, 3MINT-61618 I2D: score=3 
    SFNP319472, 3MINT-3975647 I2D: score=2 
    ABL1P005193, ENSP000003614234I2D: score=4 STRING: ENSP00000361423
    GRB2P629933, ENSP000003390074I2D: score=2 STRING: ENSP00000339007
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032313regulation of Rab GTPase activity IDA--
    GO:0070374positive regulation of ERK1 and ERK2 cascade IDA9632734

    Find genes that share ontologies with ST5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ST5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ST5 gene (3 alternative transcripts): 
    NM_005418.3  NM_139157.2  NM_213618.1  

    Unigene Cluster for ST5:

    Suppression of tumorigenicity 5
    Hs.117715  [show with all ESTs]
    Unigene Representative Sequence: NM_005418
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 61):
    ENST00000526757(uc001mgu.3) ENST00000534127(uc001mgv.3) ENST00000313726(uc001mgt.3 uc009yfr.3)
    ENST00000530991(uc010rbp.2) ENST00000526099 ENST00000527540 ENST00000532162
    ENST00000534278 ENST00000524513 ENST00000530438 ENST00000532738 ENST00000526062
    ENST00000532871 ENST00000533081 ENST00000526701(uc009yfs.3) ENST00000530922
    ENST00000530559 ENST00000533020
    miRNA
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    Block miRNA regulation of human, mouse, rat ST5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ST5 (see all 23):
    hsa-miR-194* hsa-miR-140-5p hsa-miR-146b-3p hsa-miR-300 hsa-miR-520d-5p hsa-miR-486-5p hsa-miR-124 hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmidST5 3' UTR sequence
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ST5 (NM_001900)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST5
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    OriGene qSTAR qPCR primer pairs in human, mouse for ST5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ST5
      QuantiTect SYBR Green Assays in human, mouse, rat ST5
      QuantiFast Probe-based Assays in human, mouse, rat ST5

    Additional mRNA sequence: 

    AK123380.1 AK126554.1 AK127763.1 AK293245.1 AK302824.1 AK307617.1 AK309929.1 AK312305.1 
    AK312758.1 BC036655.1 BX647431.1 BX647474.1 S45936.1 U15131.1 U15779.1 U15780.1 

    Selected DOTS entries (see all 35):

    DT.91832935  DT.100785453  DT.101981184  DT.455736  DT.92438514  DT.100785460  DT.75188964  DT.100785456 
    DT.120726121  DT.99977160  DT.95148226  DT.120726016  DT.120726172  DT.97795613  DT.95148234  DT.100785461 
    DT.120726144  DT.120726150  DT.86853926  DT.92039293  DT.92438516  DT.100739170  DT.100785458  DT.120725943 

    Selected AceView cDNA sequences (see all 301):

    AW082200 BM831581 BE048030 F04298 AI312826 BU785405 NM_213618 BF445922 
    BQ022969 U15780 BM972253 BU528932 BM987518 AL043546 CO247902 BQ878881 
    AU139710 CA441929 AK127763 BU193497 BQ720478 NM_139157 BQ003360 AW300796 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ST5 (see all 30)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d · 14e · 14f · 14g ·
    SP1:        -     -     -     -           -     -     -     -     -     -     -     -     -     -     -     -                                                   
    SP2:                                                                          -     -     -     -     -     -                                                   
    SP3:                                      -     -     -     -     -     -     -     -     -     -     -     -           -     -     -     -     -     -     -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 14h · 14i · 14j ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^
    SP1:                                                  -     -     -                                                                 -           -               
    SP2:                                                  -     -     -                                                                 -           -               
    SP3:  -     -     -     -     -     -                 -     -     -                                                                 -           -               
    SP4:                                                        -     -                                                                 -           -               
    SP5:                                                                                                                                                            

    ExUns: 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35a · 35b · 35c ^ 36 ^ 37a · 37b
    SP1:              -                 -           -     -                                             
    SP2:              -                 -           -     -                                             
    SP3:              -                 -           -     -                                             
    SP4:              -                 -           -     -                                             
    SP5:                                -           -     -                                             


    ECgene alternative splicing isoforms for ST5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ST5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAGCCCAC
    ST5 Expression
    About this image

    ST5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ST5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.117715

    UniProtKB/Swiss-Prot: ST5_HUMAN, P78524
    Tissue specificity: Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in
    several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level).
    Isoform 3 is expressed in primary cell or weakly tumorigenic but not in tumorigenic cell lines (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ST5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St51 , 5 suppression of tumorigenicity 51, 5 89.95(n)1
    93.3(a)1
      7 (57.27 cM)5
    769541  NM_001001326.11  NP_001001326.11 
     1095239115 
    chicken
    (Gallus gallus)
    Aves ST51 suppression of tumorigenicity 5 74.46(n)
    81.72(a)
      423055  XM_420988.3  XP_420988.2 
    lizard
    (Anolis carolinensis)
    Reptilia ST56
    suppression of tumorigenicity 5
    78(a)
    1 ↔ 1
    1(64597827-64731020)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.19162 Xenopus laevis transcribed sequence with strong similarity more 80.08(n)    CF285575.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.163062 Transcribed sequence with moderate similarity to protein more 79.74(n)    CK030181.1 


    ENSEMBL Gene Tree for ST5 (if available)
    TreeFam Gene Tree for ST5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ST5 gene
    DENND5A2  DENND2D2  DENND2A2  DENND32  DENND1C2  DENND4A2  DENND4B2  DENND1B2  
    DENND1A2  DENND5B2  DENND2C2  DENND4C2  
    6 SIMAP similar genes for ST5 using alignment to 38 protein entries:     ST5_HUMAN (see all proteins):
    DKFZp667I053    DENND2A    DENND2D    DENND2C    DENND5B    DENND1B

    Find genes that share paralogs with ST5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ST5 (see all 4462)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1924115211,2
    --8382395(+) GGAATG/TTAACC 3 -- int1 ds50010--------
    rs1839864031,2
    --8382461(+) ATGCAA/GGAGTC 3 -- int1 ds50010--------
    rs1887152231,2
    --8382484(+) TCAGGC/GCTATG 3 -- int1 ds50010--------
    rs1919151401,2
    --8382597(+) CCTAAA/TAATGG 3 -- int1 ds50010--------
    rs1459297681,2
    --8382858(+) CAGGAG/TAGAGA 3 -- int1 ds50010--------
    rs1398011721,2
    --8382966(+) GTACCG/TCATCG 3 -- ut310--------
    rs10506551,2
    C,A,H--8383001(-) GCTCTC/TTGGGC 3 -- ut31 ese37Minor allele frequency- T:0.00MN NS EA NA 606
    rs790501071,2
    C,F--8383071(+) AATGAG/CAGGAC 3 -- ut311Minor allele frequency- C:0.02NA 120
    rs1845211611,2
    --8383147(+) AGGGTA/GTGGGT 3 -- ut310--------
    rs1500704031,2
    --8383172(+) CAAAAA/GATAGA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for ST5 (8714898 - 8932498 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ST5 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669920CNV Deletion23128226
    esv2744088CNV Deletion23290073
    nsv435923CNV Deletion17901297
    esv1699885CNV Deletion17803354
    esv2744087CNV Deletion23290073
    esv2744089CNV Deletion23290073
    nsv513308CNV Insertion21212237
    nsv7666CNV Insertion18451855
    esv273960CNV Insertion20981092
    nsv509388CNV Insertion20534489

    Human Gene Mutation Database (HGMD): ST5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ST5
    DNA2.0 Custom Variant and Variant Library Synthesis for ST5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 140750    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for ST5:
    Meningitis     Candidiasis

    Find genes that share disorders with ST5           About GenesLikeMe

    Genetic Association Database (GAD): ST5
    Human Genome Epidemiology (HuGE) Navigator: ST5 (1 document)

    Export disorders for ST5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ST5 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with ST5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human chromosome 11 gene which is differentially regulated in tumorigenic and nontumorigenic somatic cell hybrids of HeLa cells. (PubMed id 1390339)1, 2, 3 Lichy J.H.... Howley P.M. (Cell Growth Differ. 1992)
    2. Activation of extracellular signal-regulated kinase 2 by a novel Abl- binding protein, ST5. (PubMed id 9632734)1, 2, 9 Majidi M.... Lichy J.H. (J. Biol. Chem. 1998)
    3. Differential expression of the human ST5 gene in HeLa-fibroblast hybrid cell lines mediated by YY1: evidence that YY1 plays a part in tumor suppression. (PubMed id 8972856)1, 2, 9 Lichy J.H.... Tsai M.M. (Nucleic Acids Res. 1996)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. (PubMed id 11528127)1, 2 Amid C.... Schmidt E.R. (Cytogenet. Cell Genet. 2001)
    7. Expression of an isoform of the novel signal transduction protein ST5 is linked to cell morphology. (PubMed id 10229203)1, 2 Hubbs A.E.... Lichy J.H. (Oncogene 1999)
    8. Deletion of the COOH terminus converts the ST5 p70 protein from an inhibitor of RAS signaling to an activator with transforming activity in NIH-3T3 cells. (PubMed id 10692462)1, 9 Majidi M....Lichy J.H. (J. Biol. Chem. 2000)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Disruption of ST5 is associated with mental retardation and multiple congenital anomalies. (PubMed id 19843505)1 GAPhring I....Rauch A. (J. Med. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6764 HGNC: 11350 AceView: ST5 Ensembl:ENSG00000166444 euGenes: HUgn6764
    ECgene: ST5 H-InvDB: ST5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ST5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ST5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ST5 gene:
    Search GeneIP for patents involving ST5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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