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ST3GAL6 Gene

protein-coding GIFtS: 59
GCID: GC03P098451

ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 6

(Previous name: sialyltransferase 10 (alpha-2,3-sialyltransferase VI))
(Previous symbol: SIAT10)

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 6¹ ²		EC 2.4.99.-³
SIAT10¹ ² ³		ST3GalVI³
Sialyltransferase 10 (Alpha-2,3-Sialyltransferase VI)¹ ²		Sialyltransferase 10³
CMP-NeuAc:Beta-Galactoside Alpha-2,3-Sialyltransferase VI² ³		ST3Gal VI³
ST3GALVI² ⁵		EC 2.4.99⁸
Alpha2,3-Sialyltransferase ST3Gal VI²		EC 2.4.99.9⁸
Type 2 Lactosamine Alpha-2,3-Sialyltransferase²

External Ids:	HGNC: 18080¹	Entrez Gene: 10402²	Ensembl: ENSG00000064225⁷	OMIM: 607156⁵	UniProtKB: Q9Y274³

ORGUL members:

Export aliases for ST3GAL6 gene to outside databases

Previous GC identifers: GC03P099935 GC03P095823

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ST3GAL6 Gene:

The protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes

that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal

positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This

protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates

and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for

cell-to-cell recognition and a blood group antigen. Alternative splicing results in multiple transcript variants

that encode different protein isoforms. (provided by RefSeq, Sep 2012)

GeneCards Summary for ST3GAL6 Gene:

ST3GAL6 (ST3 beta-galactoside alpha-2,3-sialyltransferase 6) is a protein-coding gene. Diseases associated with ST3GAL6 include inflammatory breast carcinoma, and sialuria. GO annotations related to this gene include beta-galactoside alpha-2,3-sialyltransferase activity. An important paralog of this gene is ST3GAL3.

UniProtKB/Swiss-Prot: SIA10_HUMAN, Q9Y274

Function: Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a

alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a

restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide

and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000003.12 NT_005612.17 NC_018914.2

Regulatory elements:

Regulatory transcription factor binding sites in the ST3GAL6 gene promoter:
SREBP-1c RelA NF-kappaB GATA-1 SREBP-1b E2F SREBP-1a E2F-1 NF-kappaB1 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ST3GAL6 promoter sequence

Search Chromatin IP Primers for ST3GAL6

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST3GAL6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q12.1 Ensembl cytogenetic band: 3q12.1 HGNC cytogenetic band: 3q12.2

ST3GAL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST3GAL6 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P098451: view genomic region (about GC identifiers)

Start:	98,451,080 bp from pter	End:	98,540,045 bp from pter
Size:	88,966 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SIA10_HUMAN, Q9Y274 (See protein sequence)

Recommended Name: Type 2 lactosamine alpha-2,3-sialyltransferase

Size: 331 amino acids; 38214 Da

Secondary accessions: B2RCH2 B3KMI1 D3DN39 F8W6U0

Alternative splicing: 2 isoforms: Q9Y274-1 Q9Y274-2

Explore the universe of human proteins at neXtProt for ST3GAL6: NX_Q9Y274

Explore proteomics data for ST3GAL6 at MOPED

Post-translational modifications:

Glycosylation² at Asn129, Asn181, Asn282, Asn295, Asn308, Asn327

Selected DME Specific Peptides for ST3GAL6 (Q9Y274) (see all 14)

RLFYPES

CVVVGNG

LSKLQSCDL

GYLVAIFLS

See ST3GAL6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (6 alternative transcripts):

NP_001258071.1 NP_001258074.1 NP_001258075.1 NP_001258076.1 NP_001258077.1 NP_006091.1

ENSEMBL proteins:

ENSP00000417376 ENSP00000419209 ENSP00000419690 ENSP00000420047 ENSP00000417584

ENSP00000418896 ENSP00000418581 ENSP00000417109 ENSP00000420474 ENSP00000418650

ENSP00000420693 ENSP00000417201 ENSP00000419987 ENSP00000419202 ENSP00000377717

ENSP00000265261

Reactome Protein details: Q9Y274

ST3GAL6 Human Recombinant Protein Products:

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ST3GAL6 Antibody Products:

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ST3GAL6 Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

ST3G: Sialyltransferases

2 InterPro protein domains:

IPR001675 Glyco_trans_29

IPR012163 Sialyl_trans

Graphical View of Domain Structure for InterPro Entry Q9Y274

ProtoNet protein and cluster: Q9Y274

1 Blocks protein domain: IPB001675 Glycosyl transferase

UniProtKB/Swiss-Prot: SIA10_HUMAN, Q9Y274

Similarity: Belongs to the glycosyltransferase 29 family

ST3GAL6 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: SIA10_HUMAN, Q9Y274

Function: Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a

alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a

restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide

and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1

Enzyme Numbers (IUBMB): EC 2.4.99.9² EC 2.4.99.-¹ EC 2.4.99²

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008373	sialyltransferase activity	--	--
GO:0052798	beta-galactoside alpha-2,3-sialyltransferase activity	IDA	10206952

ST3GAL6 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ST3GAL6:

Increased cell death in breast

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for St3gal6):

cellular

hematopoietic system

immune system

ST3GAL6 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out St3gal6^tm1.1Jxm for ST3GAL6

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ST3GAL6

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genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ST3GAL6

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ST3GAL6

miRNA Products:		miRTarBase miRNAs that target ST3GAL6: hsa-mir-215-5p (MIRT024498), hsa-mir-192-5p (MIRT026490)

		Block miRNA regulation of human, mouse, rat ST3GAL6 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate ST3GAL6 (see all 14):
		hsa-miR-1226 hsa-miR-27a hsa-miR-513a-5p hsa-miR-548e hsa-miR-548o hsa-miR-876-3p hsa-miR-1911* hsa-miR-21

		SwitchGear 3'UTR luciferase reporter plasmid: ST3GAL6 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST3GAL6

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

SIA10_HUMAN, Q9Y274: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
golgi apparatus	5
endoplasmic reticulum	2
extracellular	1

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Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	--
GO:0005794	Golgi apparatus	--	--
GO:0016021	integral component of membrane	NAS	10206952
GO:0030173	integral component of Golgi membrane	IEA	--
GO:0070062	extracellular vesicular exosome	IDA	19199708

ST3GAL6 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ST3GAL6 About (see all 8)

See pathways by source

SuperPath

Selected contained pathways About (see all per SuperPath)

Metabolism

Metabolism

0.38

Metabolic pathways

0.38

MPS VI - Maroteaux-Lamy syndrome

MPS VI - Maroteaux-Lamy syndrome	0.45	MPS IIIB - Sanfilippo syndrome B	0.45
MPS IIIC - Sanfilippo syndrome C	0.45	MPS II - Hunter syndrome	0.45
MPS IV - Morquio syndrome A	0.45	Glycosaminoglycan metabolism	0.45
Mucopolysaccharidoses	0.45	MPS IV - Morquio syndrome B	0.45

Keratan sulfate/keratin metabolism

Keratan sulfate/keratin metabolism

0.85

Keratan sulfate biosynthesis

0.85

Pre-NOTCH Expression and Processing

Pre-NOTCH Expression and Processing

0.62

Pre-NOTCH Processing in Golgi

0.00

Signaling by NOTCH1 PEST Domain Mutants in Cancer

Signaling by NOTCH

0.64

Pathways by source See SuperPaths
Show all pathways

3 Reactome Pathways for ST3GAL6

	Pre-NOTCH Processing in Golgi
	Sialic acid metabolism
	Keratan sulfate biosynthesis

2 Kegg Pathways (Kegg details for ST3GAL6):

	Glycosphingolipid biosynthesis - lacto and neolacto series
	Metabolic pathways

ST3GAL6 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for ST3GAL6
Interactions:

Search GeneGlobe Interaction Network for ST3GAL6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for ST3GAL6 (ENSP00000377717⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 28)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
B4GALT1	ENSP00000369055⁴	STRING: ENSP00000369055
CHST6	ENSP00000328983⁴	STRING: ENSP00000328983
FUT1	ENSP00000312021⁴	STRING: ENSP00000312021
FUT4	ENSP00000351602⁴	STRING: ENSP00000351602
FUT6	ENSP00000286955⁴	STRING: ENSP00000286955

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Gene Ontology (GO): Selected biological process terms (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006464	cellular protein modification process	IDA	10206952
GO:0006486	protein glycosylation	IEA	--
GO:0006664	glycolipid metabolic process	IDA	10206952
GO:0009311	oligosaccharide metabolic process	IDA	10206952

ST3GAL6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for ST3GAL6 (SIA10)

3 HMDB Compounds for ST3GAL6 About this table

Compound	Synonyms	CAS #	PubMed Ids
Cytidine monophosphate	5'-CMP (see all 14)	63-37-6	--
Cytidine monophosphate N-acetylneuraminic acid	CMP-N-acetylneuraminate (see all 6)	22-12-8	--
Sialyl-Lewis X	3'-Sialyl-Lewis X (see all 8)	98603-84-0	--

3 Novoseek inferred chemical compound relationships for ST3GAL6 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gal(beta1-3)galnac	73.7	1	9628888 (1)
sialic acid	72.5	1	9182658 (1)
asialo gm1	70.2	1	12716912 (1)

ST3GAL6 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ST3GAL6 gene (6 alternative transcripts):

NM_001271142.1 NM_001271145.1 NM_001271146.1 NM_001271147.1 NM_001271148.1 NM_006100.3

Unigene Cluster for ST3GAL6:

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

Hs.148716 [show with all ESTs]

Unigene Representative Sequence: CR749468

Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):

ENST00000489112 ENST00000483910 ENST00000460774 ENST00000469105(uc003dsy.3 uc003dsz.3 uc003dta.3)

ENST00000466482 ENST00000462152 ENST00000486249 ENST00000497008 ENST00000486334

ENST00000480133 ENST00000497621(uc003dtc.3 uc010hpd.3) ENST00000465004

ENST00000476833 ENST00000468553 ENST00000490684 ENST00000485391 ENST00000495376

ENST00000492254

miRNA Products:		Block miRNA regulation of human, mouse, rat ST3GAL6 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate ST3GAL6 (see all 14):
		hsa-miR-1226 hsa-miR-27a hsa-miR-513a-5p hsa-miR-548e hsa-miR-548o hsa-miR-876-3p hsa-miR-1911* hsa-miR-21

		SwitchGear 3'UTR luciferase reporter plasmid: ST3GAL6 3' UTR sequence

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		Predesigned siRNA for gene silencing in human, mouse, rat ST3GAL6

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		QuantiFast Probe-based Assays in human, mouse, rat ST3GAL6

Additional mRNA sequence:

AB022918.1 AF119391.1 AK001922.1 AK315111.1 BC001266.2 BC012092.1 BC023312.1 CR749468.1

22 DOTS entries:

DT.91648904 DT.100780429 DT.441821 DT.91723321 DT.75160594 DT.92048988 DT.100654969 DT.100780433

DT.40292564 DT.442867 DT.99999677 DT.100780430 DT.100780431 DT.120914520 DT.40272715 DT.95200021

DT.99999477 DT.120914582 DT.120914610 DT.75110962 DT.91971078 DT.92419998

Selected AceView cDNA sequences (see all 155):

BX092348 AA884052 AI955457 AB022918 AI471207 CA396843 NM_006100 BC001266

BE465534 N91882 CR607538 BF589596 CA308014 AI478510 BM449842 BE348317

AI984377 BU188066 Z43713 BC023312 BU165940 AI056701 BF447500 CR624848

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL6 (see all 15) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15	^
SP1:											-		-		-		-		-		-		-										-				-				-		-		-
SP2:																			-		-		-								-		-				-				-		-		-
SP3:											-		-		-		-		-		-		-								-		-				-				-		-		-
SP4:											-		-		-		-		-		-		-										-				-				-		-		-		-		-
SP5:																	-		-		-		-								-		-				-				-		-		-

ExUns:	16	^	17	^	18a	·	18b	·	18c	·	18d	·	18e	·	18f
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ST3GAL6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ST3GAL6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATTGTGAAGA

About this image

ST3GAL6 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 5) fully expand


Kidney (Urinary System) fully expand to see all 2 entries
Podocytes Podocyte Layer
Renal Vesicle

Inner Cell Mass (Early Embryonic Tissues) fully expand to see all 2 entries
Human embryonic stem cells (family)

Epithelial Cells
Podocytes Podocyte Layer

Blood (Hematopoietic System)
Granulocytes Peripheral Blood

Neural Tube (Nervous System)
Mesencephalic Floor Plate

ST3GAL6 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ST3GAL6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.148716

UniProtKB/Swiss-Prot: SIA10_HUMAN, Q9Y274

Tissue specificity: Ubiquitous

Custom PCR Arrays for ST3GAL6

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST3GAL6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ST3GAL6 gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	St3gal6^{1 , 5}	ST3 beta-galactoside alpha-2,3-sialyltransferase 6^{1, 5}	81.46(n)¹ 74.47(a)¹		16 (34.58 cM)⁵ 54613¹ NM_018784.2¹ NP_061254.1¹ 58468125⁵
chicken (Gallus gallus)	Aves	ST3GAL6¹	ST3 beta-galactoside alpha-2,3-sialyltransferase 6	69.1(n) 63.83(a)		395138 NM_204479.1 NP_989810.1
lizard (Anolis carolinensis)	Reptilia	ST3GAL6⁶	ST3 beta-galactoside alpha-2,3-sialyltransferase 6...	55(a)	1 ↔ 1	3(174911192-174949257)
African clawed frog (Xenopus laevis)	Amphibia	st3Gal-VI²	alpha2,3-sialyltransferase	72.66(n)		AJ585766.1
zebrafish (Danio rerio)	Actinopterygii	st3gal5l⁶	ST3 beta-galactoside alpha-2,3-sialyltransferase 5...	26(a)	many ↔ many	13(41328377-41338923) ENSDARG00000039064

ENSEMBL Gene Tree for ST3GAL6 (if available)
TreeFam Gene Tree for ST3GAL6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ST3GAL6 gene

ST3GAL3² ST6GALNAC1² ST6GALNAC2² ST3GAL1² ST3GAL4² ST3GAL2² ST3GAL5²

6 SIMAP similar genes for ST3GAL6 using alignment to 11 protein entries: SIA10_HUMAN (see all proteins):

ST3GAL1 ST3GAL4 ST3GAL3 SIAT4C ST3GAL5 ST3GalIII

ST3GAL6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147021296^1,2		--	98426468(+)	`TATTAC/TCTCAC`	2	--	us2k¹		0	--	--	--	--
rs116879258^1,2	C,F	--	98453548(+)	`ACCTTT/CGAGGC`	6	--	int¹		1		EA	120
rs186864187^1,2		--	98453636(+)	`ATTGTA/TAATCG`	6	--	int¹		0	--	--	--	--
rs112900972^1,2	C,F	--	98453733(+)	`ACCTTA/GTGGGA`	6	--	int¹		2		CSA WA	120
rs192282700^1,2		--	98453758(+)	`TGCCAG/TGTTTC`	6	--	int¹		0	--	--	--	--
rs148941887^1,2		--	98453777(+)	`CCCTGA/GTAAGC`	6	--	int¹		0	--	--	--	--
rs147030667^1,2		--	98453862(+)	`GATCTA/GTTTAG`	6	--	int¹		0	--	--	--	--
rs114965972^1,2	C,F	--	98453880(+)	`TTTAGG/ATGATG`	6	--	int¹		1		NA	120
rs147650452^1,2		--	98453909(+)	`GAAGCA/CTGGAA`	6	--	int¹		0	--	--	--	--
rs278373^1,2	C,F,A,H	--	98453951(+)	`GTGTTT/CTCATA`	6	--	int¹		33		NA NS EA WA CSA	2921

HapMap Linkage Disequilibrium report for ST3GAL6 (98451080 - 98540045 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for ST3GAL6: About this table

Variant ID	Type	Subtype	PubMed ID
nsv470783	CNV	Loss	18288195
nsv877214	CNV	Gain	21882294

Human Gene Mutation Database (HGMD): ST3GAL6

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ST3GAL6

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607156 OMIM disorders: --

16 diseases for ST3GAL6:
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inflammatory breast carcinoma sialuria morquio syndrome b sly syndrome

mucopolysaccharidoses major depressive disorder neuroblastoma obesity

hepatitis b hepatocellular carcinoma hepatitis endotheliitis

ovarian cancer breast cancer prostate cancer prostatitis

ST3GAL6 for disorders About GeneDecksing

2 Novoseek inferred disease relationships for ST3GAL6 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
breast carcinoma	17.7	1	10561455 (1)
carcinoma	1.99	1	11389097 (1)

Genetic Association Database (GAD): ST3GAL6
Human Genome Epidemiology (HuGE) Navigator: ST3GAL6 (1 document)

Export disorders for ST3GAL6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ST3GAL6 gene, integrated from 10 sources (see all 50):
(articles sorted by number of sources associating them with ST3GAL6)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids. (PubMed id 10206952)^{1, 2, 3, 9} Okajima T.... Furukawa K. (J. Biol. Chem. 1999)
Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PubMed id 20532202)^{1, 4} Naukkarinen J....Peltonen L. (PLoS Genet. 2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewis x epitopes in the human bronchial mucosa. (PubMed id 17944600)^{1, 9} Groux-Degroote S.... Delannoy P. (Biochem. J. 2008)
Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands. (PubMed id 22700726)¹ Yang W.H....Sperandio M. (Blood 2012)
A fine-mapping study of 7 top scoring genes from a GWAS for major depressive disorder. (PubMed id 22649524)¹ Verbeek E.C....Heutink P. (PLoS ONE 2012)
Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers. (PubMed id 22025563)¹ Julien S....Burchell J.M. (Cancer Res. 2011)
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
Differences in CD75s- and iso-CD75s-ganglioside content and altered mRNA expression of sialyltransferases ST6GAL1 and ST3GAL6 in human hepatocellular carcinomas and nontumoral liver tissues. (PubMed id 21147760)¹ Souady J....MA1thing J. (Glycobiology 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10402	HGNC: 18080	AceView: SIAT10	Ensembl:ENSG00000064225	euGenes: HUgn10402
ECgene: ST3GAL6	Kegg: 10402	H-InvDB: ST3GAL6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ST3GAL6	Pharmacogenomics, SNPs, Pathways
GGDB	http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST3GAL6
Functional Glycomics Gateway - GTase	http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_627

Intellectual Property for ST3GAL6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ST3GAL6 gene:
Search GeneIP for patents involving ST3GAL6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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ST3GAL6 Gene

ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 6

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ST3GAL6 Gene

ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 6

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