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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ST3GAL6 Gene

protein-coding   GIFtS: 57
GCID: GC03P098451

ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 6

(Previous name: sialyltransferase 10 (alpha-2,3-sialyltransferase VI))
(Previous symbol: SIAT10)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 61 2     EC 2.4.99.-3
SIAT101 2 3     ST3GalVI3
Sialyltransferase 10 (Alpha-2,3-Sialyltransferase VI)1 2     Sialyltransferase 103
CMP-NeuAc:Beta-Galactoside Alpha-2,3-Sialyltransferase VI2 3     ST3Gal VI3
ST3GALVI2 5     EC 2.4.998
Alpha2,3-Sialyltransferase ST3Gal VI2     EC 2.4.99.98
Type 2 Lactosamine Alpha-2,3-Sialyltransferase2     

External Ids:    HGNC: 180801   Entrez Gene: 104022   Ensembl: ENSG000000642257   OMIM: 6071565   UniProtKB: Q9Y2743   

Export aliases for ST3GAL6 gene to outside databases

Previous GC identifers: GC03P099935 GC03P095823


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ST3GAL6 Gene:
The protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes
that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal
positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This
protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates
and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for
cell-to-cell recognition and a blood group antigen. Alternative splicing results in multiple transcript variants
that encode different protein isoforms. (provided by RefSeq, Sep 2012)

GeneCards Summary for ST3GAL6 Gene: 
ST3GAL6 (ST3 beta-galactoside alpha-2,3-sialyltransferase 6) is a protein-coding gene. Diseases associated with ST3GAL6 include sialuria, and inflammatory breast carcinoma, and among its related super-pathways are Metabolic pathways and Metabolism of carbohydrates. GO annotations related to this gene include beta-galactoside alpha-2,3-sialyltransferase activity. An important paralog of this gene is ST3GAL3.

UniProtKB/Swiss-Prot: SIA10_HUMAN, Q9Y274
Function: Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a
alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a
restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide
and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ST3GAL6 gene promoter:
         SREBP-1c   RelA   NF-kappaB   GATA-1   SREBP-1b   E2F   SREBP-1a   E2F-1   NF-kappaB1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidST3GAL6 promoter sequence
   Search SABiosciences Chromatin IP Primers for ST3GAL6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST3GAL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q12.1   Ensembl cytogenetic band:  3q12.1   HGNC cytogenetic band: 3q12.2

ST3GAL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST3GAL6 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P098451:  view genomic region     (about GC identifiers)

Start:
98,451,080 bp from pter      End:
98,540,045 bp from pter
Size:
88,966 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SIA10_HUMAN, Q9Y274 (See protein sequence)
Recommended Name: Type 2 lactosamine alpha-2,3-sialyltransferase  
Size: 331 amino acids; 38214 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
Secondary accessions: B2RCH2 B3KMI1 D3DN39 F8W6U0
Alternative splicing: 2 isoforms:  Q9Y274-1   Q9Y274-2   

Explore the universe of human proteins at neXtProt for ST3GAL6: NX_Q9Y274

Explore proteomics data for ST3GAL6 at MOPED 

4/14 DME Specific Peptides for ST3GAL6 (Q9Y274) (see all 14)
 RLFYPES  CVVVGNG  LSKLQSCDL  GYLVAIFLS 

ST3GAL6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

ST3GAL6 Protein Expression
REFSEQ proteins (6 alternative transcripts): 
NP_001258071.1  NP_001258074.1  NP_001258075.1  NP_001258076.1  NP_001258077.1  NP_006091.1  

ENSEMBL proteins: 
 ENSP00000417376   ENSP00000419209   ENSP00000419690   ENSP00000420047   ENSP00000417584  
 ENSP00000418896   ENSP00000418581   ENSP00000417109   ENSP00000420474   ENSP00000418650  
 ENSP00000420693   ENSP00000417201   ENSP00000419987   ENSP00000419202   ENSP00000377717  
 ENSP00000265261  
Reactome Protein details: Q9Y274
Human Recombinant Protein Products for ST3GAL6: 
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Novus Biologicals ST3GAL6 Proteins
Novus Biologicals ST3GAL6 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000139Golgi membrane TAS--
GO:0005794Golgi apparatus ----
GO:0016021integral to membrane NAS10206952
GO:0030173integral to Golgi membrane IEA--

ST3GAL6 for ontologies           About GeneDecksing



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Abcam antibodies for ST3GAL6
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LSBio Antibodies in human, mouse, rat for ST3GAL6 

Assay Products for ST3GAL6: 
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ST3G: Sialyltransferases

2 InterPro protein domains:
 IPR001675 Glyco_trans_29
 IPR012163 Sialyl_trans

Graphical View of Domain Structure for InterPro Entry Q9Y274

ProtoNet protein and cluster: Q9Y274

1 Blocks protein domain: IPB001675 Glycosyl transferase

UniProtKB/Swiss-Prot: SIA10_HUMAN, Q9Y274
Similarity: Belongs to the glycosyltransferase 29 family


ST3GAL6 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: SIA10_HUMAN, Q9Y274
Function: Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a
alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a
restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide
and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1

     Enzyme Numbers (IUBMB): EC 2.4.99.92 EC 2.4.99.-1 EC 2.4.992

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008373sialyltransferase activity ----
GO:0052798beta-galactoside alpha-2,3-sialyltransferase activity IDA10206952
     
ST3GAL6 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for ST3GAL6:
 Increased cell death in breast 

     3 MGI mutant phenotypes (inferred from 1 allele(MGI details for St3gal6):
 cellular  hematopoietic system  immune system 

ST3GAL6 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out St3gal6tm1.1Jxm for ST3GAL6

   inGenious Targeting Laboratory - Custom generated mouse model solutions for ST3GAL6 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ST3GAL6

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ST3GAL6 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ST3GAL6 

miRNA
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8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate ST3GAL6 (see all 14):
hsa-miR-1226 hsa-miR-27a hsa-miR-513a-5p hsa-miR-548e hsa-miR-548o hsa-miR-876-3p hsa-miR-1911* hsa-miR-21
SwitchGear 3'UTR luciferase reporter plasmidST3GAL6 3' UTR sequence
Inhib. RNA
Products:
    
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Gene Editing
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Clone
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GenScript: all cDNA clones in your preferred vector: ST3GAL6 (NM_006100)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST3GAL6
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST3GAL6
Sirion Biotech Customized lentivirus for stable overexpression of ST3GAL6 
                     Customized lentivirus expression plasmids for stable overexpression of ST3GAL6 

Cell Line
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Search LifeMap BioReagents cell lines for ST3GAL6
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST3GAL6


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for ST3GAL6 About   (see all 8)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1Metabolism
Metabolism0.40
Metabolic pathways0.40
2MPS IIIC - Sanfilippo syndrome C
MPS IIIC - Sanfilippo syndrome C0.48
Mucopolysaccharidoses0.48
MPS IV - Morquio syndrome A0.48
MPS IIID - Sanfilippo syndrome D0.48
MPS IV - Morquio syndrome B0.48
MPS I - Hurler syndrome0.48
MPS VI - Maroteaux-Lamy syndrome0.48
MPS IX - Natowicz syndrome0.48
3Keratan sulfate biosynthesis
Keratan sulfate biosynthesis0.82
Keratan sulfate/keratin metabolism0.82
4Pre-NOTCH Processing in Golgi
Pre-NOTCH Expression and Processing0.55
Pre-NOTCH Processing in Golgi0.55
5Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant
Signaling by NOTCH0.74

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


5/22        Reactome Pathways for ST3GAL6 (see all 22)
    Pre-NOTCH Expression and Processing
MPS VI - Maroteaux-Lamy syndrome
Metabolism
Disease
Keratan sulfate/keratin metabolism


2         Kegg Pathways  (Kegg details for ST3GAL6):
    Glycosphingolipid biosynthesis - lacto and neolacto series
Metabolic pathways


ST3GAL6 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ST3GAL6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/28 Interacting proteins for ST3GAL6 (ENSP000003777174) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
InteractantInteraction Details
GeneCardExternal ID(s)
B4GALT1ENSP000003690554STRING: ENSP00000369055
CHST6ENSP000003289834STRING: ENSP00000328983
FUT1ENSP000003120214STRING: ENSP00000312021
FUT4ENSP000003516024STRING: ENSP00000351602
FUT6ENSP000002869554STRING: ENSP00000286955
About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005975carbohydrate metabolic process TAS--
GO:0006464cellular protein modification process IDA10206952
GO:0006486protein glycosylation IEA--
GO:0006664glycolipid metabolic process IDA10206952
GO:0009311oligosaccharide metabolic process IDA10206952

ST3GAL6 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ST3GAL6 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ST3GAL6 (SIA10)

3 HMDB Compounds for ST3GAL6    About this table
CompoundSynonyms CAS #PubMed Ids
Cytidine monophosphate5'-CMP (see all 14)63-37-6--
Cytidine monophosphate N-acetylneuraminic acidCMP-N-acetylneuraminate (see all 6)22-12-8--
Sialyl-Lewis X3'-Sialyl-Lewis X (see all 8)98603-84-0--

3 Novoseek inferred chemical compound relationships for ST3GAL6 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
gal(beta1-3)galnac 73.7 1 9628888 (1)
sialic acid 72.5 1 9182658 (1)
asialo gm1 70.2 1 12716912 (1)

Search CenterWatch for drugs/clinical trials and news about ST3GAL6 / SIA10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ST3GAL6 gene (6 alternative transcripts): 
NM_001271142.1  NM_001271145.1  NM_001271146.1  NM_001271147.1  NM_001271148.1  NM_006100.3  

Unigene Cluster for ST3GAL6:

ST3 beta-galactoside alpha-2,3-sialyltransferase 6
Hs.148716  [show with all ESTs]
Unigene Representative Sequence: CR749468
18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
ENST00000489112 ENST00000483910 ENST00000460774 ENST00000469105(uc003dsy.3 uc003dsz.3 uc003dta.3)
ENST00000466482 ENST00000462152 ENST00000486249 ENST00000497008 ENST00000486334
ENST00000480133 ENST00000497621(uc003dtc.3 uc010hpd.3) ENST00000465004
ENST00000476833 ENST00000468553 ENST00000490684 ENST00000485391 ENST00000495376
ENST00000492254
miRNA
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hsa-miR-1226 hsa-miR-27a hsa-miR-513a-5p hsa-miR-548e hsa-miR-548o hsa-miR-876-3p hsa-miR-1911* hsa-miR-21
SwitchGear 3'UTR luciferase reporter plasmidST3GAL6 3' UTR sequence
Inhib. RNA
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Additional mRNA sequence: 

AB022918.1 AF119391.1 AK001922.1 AK315111.1 BC001266.2 BC012092.1 BC023312.1 CR749468.1 

22 DOTS entries:

DT.91648904  DT.100780429  DT.441821  DT.91723321  DT.75160594  DT.92048988  DT.100654969  DT.100780433 
DT.40292564  DT.442867  DT.99999677  DT.100780430  DT.100780431  DT.120914520  DT.40272715  DT.95200021 
DT.99999477  DT.120914582  DT.120914610  DT.75110962  DT.91971078  DT.92419998 

24/155 AceView cDNA sequences (see all 155):

AB022918 AI478510 CA396843 AI056701 BC001266 BM449842 BF589596 AI471207 
BF447500 Z43713 AI955457 N91882 CA308014 BC023312 BE465534 BU165940 
BX092348 AA884052 NM_006100 CR624848 BE348317 BU188066 AI984377 CR607538 

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL6 (see all 15)    About this scheme

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^
SP1:                                -     -     -     -     -     -     -                             -           -           -     -     -                     
SP2:                                                        -     -     -                       -     -           -           -     -     -                     
SP3:                                -     -     -     -     -     -     -                       -     -           -           -     -     -                     
SP4:                                -     -     -     -     -     -     -                             -           -           -     -     -     -     -         
SP5:                                                  -     -     -     -                       -     -           -           -     -     -                     

ExUns: 16 ^ 17 ^ 18a · 18b · 18c · 18d · 18e · 18f
SP1:                                                
SP2:                                                
SP3:                                                
SP4:                                                
SP5:                                                


ECgene alternative splicing isoforms for ST3GAL6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ST3GAL6 expression in normal human tissues (normalized intensities)      ST3GAL6 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATTGTGAAGA
ST3GAL6 Expression
About this image


ST3GAL6 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/4 selected tissues (see all 4) fully expand
 
 Kidney (Urinary System)    fully expand to see all 2 entries
         Podocytes Podocyte Layer
         Renal Vesicle
 
 Umbilical Cord (Extraembryonic Tissues)
         stem cells (umbilical cord cd34+)   
 
 Blood (Extraembryonic Tissues)
         stem cells (umbilical cord cd34+)   
 
 Neural Tube (Nervous System)
         Mesencephalic Floor Plate

See ST3GAL6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ST3GAL6

SOURCE GeneReport for Unigene cluster: Hs.148716

UniProtKB/Swiss-Prot: SIA10_HUMAN, Q9Y274
Tissue specificity: Ubiquitous

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ST3GAL6 gene from 4/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia St3gal61 , 5 ST3 beta-galactoside alpha-2,3-sialyltransferase 61, 5 81.46(n)1
74.47(a)1
  16 (34.58 cM)5
546131  NM_018784.21  NP_061254.11 
 584681255 
chicken
(Gallus gallus)
Aves ST3GAL61 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 69.1(n)
63.83(a)
  395138  NM_204479.1  NP_989810.1 
lizard
(Anolis carolinensis)
Reptilia ST3GAL66
ST3 beta-galactoside alpha-2,3-sialyltransferase 6...
55(a)
1 ↔ 1
3(174911192-174949257)
African clawed frog
(Xenopus laevis)
Amphibia st3Gal-VI2 alpha2,3-sialyltransferase 72.66(n)    AJ585766.1 


ENSEMBL Gene Tree for ST3GAL6 (if available)
TreeFam Gene Tree for ST3GAL6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ST3GAL6 gene
ST3GAL32  ST6GALNAC12  ST6GALNAC22  ST3GAL12  ST3GAL42  ST3GAL22  ST3GAL52  
6 SIMAP similar genes for ST3GAL6 using alignment to 11 protein entries:     SIA10_HUMAN (see all proteins):
ST3GAL1    ST3GAL4    ST3GAL3    SIAT4C    ST3GAL5    ST3GalIII

ST3GAL6 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1229 SNPs in ST3GAL6 are shown (see all 1229)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1470212961,2
--98426468(+) TATTAC/TCTCAC 2 -- us2k10--------
rs1168792581,2
C,F--98453548(+) ACCTTT/CGAGGC 6 -- int11Minor allele frequency- C:0.02EA 120
rs1868641871,2
--98453636(+) ATTGTA/TAATCG 6 -- int10--------
rs1129009721,2
C,F--98453733(+) ACCTTA/GTGGGA 6 -- int12Minor allele frequency- G:0.05CSA WA 120
rs1922827001,2
--98453758(+) TGCCAG/TGTTTC 6 -- int10--------
rs1489418871,2
--98453777(+) CCCTGA/GTAAGC 6 -- int10--------
rs1470306671,2
--98453862(+) GATCTA/GTTTAG 6 -- int10--------
rs1149659721,2
C,F--98453880(+) TTTAGG/ATGATG 6 -- int11Minor allele frequency- A:0.02NA 120
rs1476504521,2
--98453909(+) GAAGCA/CTGGAA 6 -- int10--------
rs2783731,2
C,F,A,H--98453951(+) GTGTTT/CTCATA 6 -- int133Minor allele frequency- C:0.44NA NS EA WA CSA 2921

HapMap Linkage Disequilibrium report for ST3GAL6 (98451080 - 98540045 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for ST3GAL6:    About this table     
Variant IDTypeSubtypePubMed ID
nsv470783CNV Loss18288195
nsv877214CNV Gain21882294


Human Gene Mutation Database (HGMD): ST3GAL6
SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 607156    OMIM disorders: --

11 diseases for ST3GAL6:    About MalaCards
sialuria    inflammatory breast carcinoma    morquio syndrome b    major depressive disorder
obesity    neuroblastoma    hepatitis b    hepatocellular carcinoma
endotheliitis    hepatitis    breast cancer


ST3GAL6 for disorders           About GeneDecksing

2 Novoseek inferred disease relationships for ST3GAL6 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
breast carcinoma 17.7 1 10561455 (1)
carcinoma 1.99 1 11389097 (1)

Genetic Association Database (GAD): ST3GAL6
Human Genome Epidemiology (HuGE) Navigator: ST3GAL6 (1 document)

Export disorders for ST3GAL6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ST3GAL6 gene, integrated from 9 sources (see all 49):
(articles sorted by number of sources associating them with ST3GAL6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids. (PubMed id 10206952)1, 2, 3, 9 Okajima T.... Furukawa K. (1999)
  2. Use of genome-wide expression data to mine the ' Gray Zone' of GWA studies leads to novel candidate obesity genes. (PubMed id 20532202)1, 4 Naukkarinen J....Peltonen L. (2010)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewis x epitopes in the human bronchial mucosa. (PubMed id 17944600)1, 9 Groux-Degroote S.... Delannoy P. (2008)
  6. Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltra nsferases in the synthesis of selectin ligands. (PubMed id 22700726)1 Yang W.H....Sperandio M. (2012)
  7. A fine-mapping study of 7 top scoring genes from a GWA S for major depressive disorder. (PubMed id 22649524)1 Verbeek E.C....Heutink P. (2012)
  8. Selectin ligand sialyl-Lewis x antigen drives metastas is of hormone-dependent breast cancers. (PubMed id 22025563)1 Julien S....Burchell J.M. (2011)
  9. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
  10. Differences in CD75s- and iso-CD75s-ganglioside conte nt and altered mRNA expression of sialyltransferases ST6GAL1 and ST3GAL6 in hum an hepatocellular carcinomas and nontumoral liver tissues. (PubMed id 21147760)1 Souady J....MA1thing J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
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  Query String
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 10402 HGNC: 18080 AceView: SIAT10 Ensembl:ENSG00000064225 euGenes: HUgn10402
ECgene: ST3GAL6 Kegg: 10402 H-InvDB: ST3GAL6

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ST3GAL6 Pharmacogenomics, SNPs, Pathways
GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST3GAL6
Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_627

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for ST3GAL6 gene:
Search GeneIP for patents involving ST3GAL6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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