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Aliases for ST3GAL6 Gene

Aliases for ST3GAL6 Gene

  • ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 6 2 3 5
  • CMP-NeuAc:Beta-Galactoside Alpha-2,3-Sialyltransferase VI 3 4
  • Sialyltransferase 10 (Alpha-2,3-Sialyltransferase VI) 2 3
  • ST3GALVI 3 4
  • SIAT10 3 4
  • Type 2 Lactosamine Alpha-2,3-Sialyltransferase 3
  • Alpha2,3-Sialyltransferase ST3Gal VI 3
  • Sialyltransferase 10 4
  • EC 2.4.99.9 61
  • EC 2.4.99.- 4
  • ST3Gal VI 4
  • EC 2.4.99 61

External Ids for ST3GAL6 Gene

Previous HGNC Symbols for ST3GAL6 Gene

  • SIAT10

Previous GeneCards Identifiers for ST3GAL6 Gene

  • GC03P099935
  • GC03P098451
  • GC03P095823

Summaries for ST3GAL6 Gene

Entrez Gene Summary for ST3GAL6 Gene

  • The protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for cell-to-cell recognition and a blood group antigen. [provided by RefSeq, Apr 2016]

GeneCards Summary for ST3GAL6 Gene

ST3GAL6 (ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 6) is a Protein Coding gene. Diseases associated with ST3GAL6 include Sialuria. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include sialyltransferase activity and beta-galactoside alpha-2,3-sialyltransferase activity. An important paralog of this gene is ST3GAL4.

UniProtKB/Swiss-Prot for ST3GAL6 Gene

  • Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST3GAL6 Gene

Genomics for ST3GAL6 Gene

Regulatory Elements for ST3GAL6 Gene

Enhancers for ST3GAL6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F098782 1.6 FANTOM5 Ensembl ENCODE 33.9 +52.6 52616 4.9 MLX ARID4B THRB RAD21 RARA YY1 SCRT2 FOS MIXL1 THAP11 ST3GAL6 DCBLD2 ST3GAL6-AS1 CPOX OR5K4 PDLIM1P4 GC03M098805 RNU6-26P
GH03F098776 1.2 FANTOM5 Ensembl ENCODE 30.6 +46.4 46433 4.7 ELF3 ATF1 MLX ARID4B DMAP1 ZSCAN9 RAD21 RARA YY1 CREM ST3GAL6 DCBLD2 ST3GAL6-AS1 CPOX PDLIM1P4 GC03P098755
GH03F098762 0.9 FANTOM5 ENCODE 17.4 +31.6 31554 2.1 PKNOX1 HLF MAX CEBPB CEBPG RAD21 ZNF335 ZNF316 GATA3 ATF4 ST3GAL6 ST3GAL6-AS1 CPOX GC03P098755 PDLIM1P4
GH03F098769 0.5 Ensembl ENCODE 15.6 +38.1 38058 2.3 USF1 MAX STAT2 EED ZNF207 CREM MTA2 BHLHE40 JUNB CEBPB DCBLD2 ST3GAL6 ST3GAL6-AS1 PDLIM1P4 GC03P098755
GH03F098806 0.4 ENCODE 15.3 +75.2 75163 2.0 SMAD5 MTA2 CBFB BMI1 TBX21 POLR2A IKZF1 EED TARDBP NBN DCBLD2 ST3GAL6 CPOX ST3GAL6-AS1 GC03M098805 RNU6-26P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ST3GAL6 on UCSC Golden Path with GeneCards custom track

Promoters for ST3GAL6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001369034 1064 3001 SIN3A ARID4B DMAP1 ZNF48 ZNF263 SP3 SP5 MXD4 REST TBX21

Genomic Location for ST3GAL6 Gene

Chromosome:
3
Start:
98,732,236 bp from pter
End:
98,821,201 bp from pter
Size:
88,966 bases
Orientation:
Plus strand

Genomic View for ST3GAL6 Gene

Genes around ST3GAL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST3GAL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST3GAL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST3GAL6 Gene

Proteins for ST3GAL6 Gene

  • Protein details for ST3GAL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y274-SIA10_HUMAN
    Recommended name:
    Type 2 lactosamine alpha-2,3-sialyltransferase
    Protein Accession:
    Q9Y274
    Secondary Accessions:
    • B2RCH2
    • B3KMI1
    • D3DN39
    • F8W6U0

    Protein attributes for ST3GAL6 Gene

    Size:
    331 amino acids
    Molecular mass:
    38214 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ST3GAL6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ST3GAL6 Gene

Post-translational modifications for ST3GAL6 Gene

  • Glycosylation at Asn 129, Asn 181, Asn 282, Asn 295, Asn 308, and Asn 327
  • Modification sites at PhosphoSitePlus

Domains & Families for ST3GAL6 Gene

Gene Families for ST3GAL6 Gene

Protein Domains for ST3GAL6 Gene

Suggested Antigen Peptide Sequences for ST3GAL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y274

UniProtKB/Swiss-Prot:

SIA10_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST3GAL6: view

Function for ST3GAL6 Gene

Molecular function for ST3GAL6 Gene

UniProtKB/Swiss-Prot Function:
Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1.

Enzyme Numbers (IUBMB) for ST3GAL6 Gene

Gene Ontology (GO) - Molecular Function for ST3GAL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity TAS --
GO:0008373 sialyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity IDA 10206952
genes like me logo Genes that share ontologies with ST3GAL6: view
genes like me logo Genes that share phenotypes with ST3GAL6: view

Animal Models for ST3GAL6 Gene

MGI Knock Outs for ST3GAL6:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ST3GAL6 Gene

Localization for ST3GAL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST3GAL6 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST3GAL6 Gene COMPARTMENTS Subcellular localization image for ST3GAL6 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for ST3GAL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,NAS 10206952
GO:0030173 integral component of Golgi membrane IEA --
genes like me logo Genes that share ontologies with ST3GAL6: view

Pathways & Interactions for ST3GAL6 Gene

genes like me logo Genes that share pathways with ST3GAL6: view

Gene Ontology (GO) - Biological Process for ST3GAL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001574 ganglioside biosynthetic process IBA --
GO:0006464 cellular protein modification process IDA 10206952
GO:0006486 protein glycosylation IEA --
GO:0006664 glycolipid metabolic process IDA 10206952
GO:0009311 oligosaccharide metabolic process IDA 10206952
genes like me logo Genes that share ontologies with ST3GAL6: view

No data available for SIGNOR curated interactions for ST3GAL6 Gene

Drugs & Compounds for ST3GAL6 Gene

(6) Additional Compounds for ST3GAL6 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytidine monophosphate
  • 5'-CMP
  • 5-Cytidylate
  • 5-Cytidylic acid
  • CMP
  • Cytidine 5'-monophosphate
63-37-6
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-Acetylneuraminate
  • CMP-N-Acylneuraminate
  • CMP-NeuNAc
  • Cytidine 5'-monophosphate N-acetylneuraminic acid
  • Cytidine Monophosphate N-Acetylneuraminate
22-12-8
Sialyl-Lewis X
  • 3'-Sialyl-Lewis X
  • 3'-Sialyl-Lewis-X tetrasaccharide
  • 3'-SLeX
  • a-NeuNAc-(2>3)-b-D-Gal-(1>4)(a-L-Fuc-[1>3])-D-GlcNAc
  • alpha-NeuNAc-(2>3)-beta-delta-Gal-(1>4)(a-L-Fuc-[1>3])-delta-GlcNAc
98603-84-0
genes like me logo Genes that share compounds with ST3GAL6: view

Transcripts for ST3GAL6 Gene

Unigene Clusters for ST3GAL6 Gene

ST3 beta-galactoside alpha-2,3-sialyltransferase 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL6 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
SP7: - - - -
SP8: - - - - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - -
SP11: -
SP12:
SP13: - - -
SP14: - - - - -
SP15:

ExUns: 16 ^ 17 ^ 18a · 18b · 18c · 18d · 18e · 18f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for ST3GAL6 Gene

GeneLoc Exon Structure for
ST3GAL6
ECgene alternative splicing isoforms for
ST3GAL6

Expression for ST3GAL6 Gene

mRNA expression in normal human tissues for ST3GAL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST3GAL6 Gene

This gene is overexpressed in Liver (x5.6) and Heart - Left Ventricle (x4.7).

Protein differential expression in normal tissues from HIPED for ST3GAL6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.3), Serum (27.4), and Placenta (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ST3GAL6 Gene



Protein tissue co-expression partners for ST3GAL6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ST3GAL6 Gene:

ST3GAL6

SOURCE GeneReport for Unigene cluster for ST3GAL6 Gene:

Hs.148716

mRNA Expression by UniProt/SwissProt for ST3GAL6 Gene:

Q9Y274-SIA10_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with ST3GAL6: view

Primer Products

Orthologs for ST3GAL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST3GAL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST3GAL6 34 35
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia ST3GAL6 34 35
  • 92.85 (n)
cow
(Bos Taurus)
Mammalia ST3GAL6 34 35
  • 89.53 (n)
mouse
(Mus musculus)
Mammalia St3gal6 34 16 35
  • 81.46 (n)
rat
(Rattus norvegicus)
Mammalia St3gal6 34
  • 80.36 (n)
oppossum
(Monodelphis domestica)
Mammalia ST3GAL6 35
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 31 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ST3GAL6 34 35
  • 69.1 (n)
lizard
(Anolis carolinensis)
Reptilia ST3GAL6 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st3gal6 34
  • 59.45 (n)
African clawed frog
(Xenopus laevis)
Amphibia st3Gal-VI 34
zebrafish
(Danio rerio)
Actinopterygii st3gal5l 35
  • 26 (a)
ManyToMany
Species where no ortholog for ST3GAL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST3GAL6 Gene

ENSEMBL:
Gene Tree for ST3GAL6 (if available)
TreeFam:
Gene Tree for ST3GAL6 (if available)

Paralogs for ST3GAL6 Gene

genes like me logo Genes that share paralogs with ST3GAL6: view

Variants for ST3GAL6 Gene

Sequence variations from dbSNP and Humsavar for ST3GAL6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1036675 -- 98,794,159(-) TGATT(C/T)TCCAC utr-variant-3-prime
rs10470451 -- 98,738,087(+) ccccc(G/T)ccctc intron-variant
rs10470452 -- 98,738,097(+) ccccc(C/G/T)acccc intron-variant
rs10546770 -- 98,731,038(+) AGATA(-/GACA)AATTC intron-variant, upstream-variant-2KB
rs10576193 -- 98,772,632(+) ACCCC(-/ATTCT)ATGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST3GAL6 Gene

Variant ID Type Subtype PubMed ID
nsv470783 CNV loss 18288195
nsv591065 CNV gain 21841781

Variation tolerance for ST3GAL6 Gene

Residual Variation Intolerance Score: 55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.70; 66.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ST3GAL6 Gene

Human Gene Mutation Database (HGMD)
ST3GAL6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST3GAL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST3GAL6 Gene

Disorders for ST3GAL6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ST3GAL6 Gene - From: GeneCards

Disorder Aliases PubMed IDs
sialuria
  • infantile sialic acid storage disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ST3GAL6

Genetic Association Database (GAD)
ST3GAL6
Human Genome Epidemiology (HuGE) Navigator
ST3GAL6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ST3GAL6
genes like me logo Genes that share disorders with ST3GAL6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST3GAL6 Gene

Publications for ST3GAL6 Gene

  1. Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids. (PMID: 10206952) Okajima T. … Furukawa K. (J. Biol. Chem. 1999) 2 3 4 22 64
  2. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J. … Peltonen L. (PLoS Genet. 2010) 3 46 64
  3. IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewis x epitopes in the human bronchial mucosa. (PMID: 17944600) Groux-Degroote S. … Delannoy P. (Biochem. J. 2008) 3 22 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ST3GAL6 Gene

Sources for ST3GAL6 Gene

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