Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ST3GAL6 Gene

Aliases for ST3GAL6 Gene

  • ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 6 2 3 5
  • CMP-NeuAc:Beta-Galactoside Alpha-2,3-Sialyltransferase VI 3 4
  • Sialyltransferase 10 (Alpha-2,3-Sialyltransferase VI) 2 3
  • ST3GALVI 3 4
  • SIAT10 3 4
  • Alpha2,3-Sialyltransferase ST3Gal VI 3
  • Sialyltransferase 10 4
  • EC 2.4.99.9 63
  • EC 2.4.99.- 4
  • ST3Gal VI 4
  • EC 2.4.99 63

External Ids for ST3GAL6 Gene

Previous HGNC Symbols for ST3GAL6 Gene

  • SIAT10

Previous GeneCards Identifiers for ST3GAL6 Gene

  • GC03P099935
  • GC03P098451
  • GC03P095823

Summaries for ST3GAL6 Gene

Entrez Gene Summary for ST3GAL6 Gene

  • The protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for cell-to-cell recognition and a blood group antigen. [provided by RefSeq, Apr 2016]

GeneCards Summary for ST3GAL6 Gene

ST3GAL6 (ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 6) is a Protein Coding gene. Diseases associated with ST3GAL6 include sialuria. Among its related pathways are Glycosphingolipid biosynthesis - lacto and neolacto series and Metabolism. GO annotations related to this gene include sialyltransferase activity and beta-galactoside alpha-2,3-sialyltransferase activity. An important paralog of this gene is ST3GAL4.

UniProtKB/Swiss-Prot for ST3GAL6 Gene

  • Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST3GAL6 Gene

Genomics for ST3GAL6 Gene

Regulatory Elements for ST3GAL6 Gene

Enhancers for ST3GAL6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ST3GAL6 on UCSC Golden Path with GeneCards custom track

Promoters for ST3GAL6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ST3GAL6 on UCSC Golden Path with GeneCards custom track

Genomic Location for ST3GAL6 Gene

Chromosome:
3
Start:
98,732,236 bp from pter
End:
98,821,201 bp from pter
Size:
88,966 bases
Orientation:
Plus strand

Genomic View for ST3GAL6 Gene

Genes around ST3GAL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST3GAL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST3GAL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST3GAL6 Gene

Proteins for ST3GAL6 Gene

  • Protein details for ST3GAL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y274-SIA10_HUMAN
    Recommended name:
    Type 2 lactosamine alpha-2,3-sialyltransferase
    Protein Accession:
    Q9Y274
    Secondary Accessions:
    • B2RCH2
    • B3KMI1
    • D3DN39
    • F8W6U0

    Protein attributes for ST3GAL6 Gene

    Size:
    331 amino acids
    Molecular mass:
    38214 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ST3GAL6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ST3GAL6 Gene

Proteomics data for ST3GAL6 Gene at MOPED

Post-translational modifications for ST3GAL6 Gene

  • Glycosylation at Asn 129, Asn 181, Asn 282, Asn 295, Asn 308, and Asn 327
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for ST3GAL6 Gene

Gene Families for ST3GAL6 Gene

Protein Domains for ST3GAL6 Gene

Suggested Antigen Peptide Sequences for ST3GAL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y274

UniProtKB/Swiss-Prot:

SIA10_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST3GAL6: view

Function for ST3GAL6 Gene

Molecular function for ST3GAL6 Gene

UniProtKB/Swiss-Prot Function:
Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1.

Enzyme Numbers (IUBMB) for ST3GAL6 Gene

genes like me logo Genes that share phenotypes with ST3GAL6: view

Animal Models for ST3GAL6 Gene

MGI Knock Outs for ST3GAL6:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ST3GAL6 Gene

Localization for ST3GAL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST3GAL6 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST3GAL6 Gene COMPARTMENTS Subcellular localization image for ST3GAL6 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for ST3GAL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0030173 integral component of Golgi membrane IEA --
genes like me logo Genes that share ontologies with ST3GAL6: view

Pathways & Interactions for ST3GAL6 Gene

genes like me logo Genes that share pathways with ST3GAL6: view

Interacting Proteins for ST3GAL6 Gene

Gene Ontology (GO) - Biological Process for ST3GAL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001574 ganglioside biosynthetic process IBA --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006464 cellular protein modification process IDA 10206952
GO:0006486 protein glycosylation IEA --
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
genes like me logo Genes that share ontologies with ST3GAL6: view

No data available for SIGNOR curated interactions for ST3GAL6 Gene

Drugs & Compounds for ST3GAL6 Gene

(6) Additional Compounds for ST3GAL6 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytidine monophosphate
  • 5'-CMP
  • 5-Cytidylate
  • 5-Cytidylic acid
  • CMP
  • Cytidine 5'-monophosphate
63-37-6
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-Acetylneuraminate
  • CMP-N-Acylneuraminate
  • CMP-NeuNAc
  • Cytidine 5'-monophosphate N-acetylneuraminic acid
  • Cytidine Monophosphate N-Acetylneuraminate
22-12-8
Sialyl-Lewis X
  • 3'-Sialyl-Lewis X
  • 3'-Sialyl-Lewis-X tetrasaccharide
  • 3'-SLeX
  • a-NeuNAc-(2>3)-b-D-Gal-(1>4)(a-L-Fuc-[1>3])-D-GlcNAc
  • alpha-NeuNAc-(2>3)-beta-delta-Gal-(1>4)(a-L-Fuc-[1>3])-delta-GlcNAc
98603-84-0
genes like me logo Genes that share compounds with ST3GAL6: view

Transcripts for ST3GAL6 Gene

Unigene Clusters for ST3GAL6 Gene

ST3 beta-galactoside alpha-2,3-sialyltransferase 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL6 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
SP7: - - - -
SP8: - - - - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - -
SP11: -
SP12:
SP13: - - -
SP14: - - - - -
SP15:

ExUns: 16 ^ 17 ^ 18a · 18b · 18c · 18d · 18e · 18f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for ST3GAL6 Gene

GeneLoc Exon Structure for
ST3GAL6
ECgene alternative splicing isoforms for
ST3GAL6

Expression for ST3GAL6 Gene

mRNA expression in normal human tissues for ST3GAL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST3GAL6 Gene

This gene is overexpressed in Liver (x5.6) and Heart - Left Ventricle (x4.7).

Protein differential expression in normal tissues from HIPED for ST3GAL6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.3), Serum (27.4), and Placenta (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ST3GAL6 Gene



SOURCE GeneReport for Unigene cluster for ST3GAL6 Gene Hs.148716

mRNA Expression by UniProt/SwissProt for ST3GAL6 Gene

Q9Y274-SIA10_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with ST3GAL6: view

Protein tissue co-expression partners for ST3GAL6 Gene

Primer Products

Orthologs for ST3GAL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST3GAL6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ST3GAL6 35
  • 89.53 (n)
  • 86.4 (a)
ST3GAL6 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ST3GAL6 35
  • 92.85 (n)
  • 94.26 (a)
ST3GAL6 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St3gal6 35
  • 81.46 (n)
  • 74.47 (a)
St3gal6 16
St3gal6 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ST3GAL6 35
  • 99.6 (n)
  • 99.7 (a)
ST3GAL6 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia St3gal6 35
  • 80.36 (n)
  • 76.74 (a)
oppossum
(Monodelphis domestica)
Mammalia ST3GAL6 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 31 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ST3GAL6 35
  • 69.1 (n)
  • 63.83 (a)
ST3GAL6 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST3GAL6 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st3gal6 35
  • 59.45 (n)
  • 56.1 (a)
African clawed frog
(Xenopus laevis)
Amphibia st3Gal-VI 35
zebrafish
(Danio rerio)
Actinopterygii st3gal5l 36
  • 26 (a)
ManyToMany
Species with no ortholog for ST3GAL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST3GAL6 Gene

ENSEMBL:
Gene Tree for ST3GAL6 (if available)
TreeFam:
Gene Tree for ST3GAL6 (if available)

Paralogs for ST3GAL6 Gene

genes like me logo Genes that share paralogs with ST3GAL6: view

Variants for ST3GAL6 Gene

Sequence variations from dbSNP and Humsavar for ST3GAL6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs28489284 - 98,793,696(+) TGACT(A/G)CAGAG reference, missense
rs12203 -- 98,795,197(+) TATGA(C/G)CTGAA utr-variant-3-prime
rs14310 -- 98,793,981(+) TTGCA(A/T)TGTTT utr-variant-3-prime
rs704580 -- 98,765,844(+) ATTCT(C/G)TTTTT intron-variant
rs704585 -- 98,784,839(+) ACTTG(C/T)GCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST3GAL6 Gene

Variant ID Type Subtype PubMed ID
nsv470783 CNV Loss 18288195
nsv877214 CNV Gain 21882294

Variation tolerance for ST3GAL6 Gene

Residual Variation Intolerance Score: 55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.70; 66.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ST3GAL6 Gene

HapMap Linkage Disequilibrium report
ST3GAL6
Human Gene Mutation Database (HGMD)
ST3GAL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST3GAL6 Gene

Disorders for ST3GAL6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ST3GAL6 Gene - From: GeneCards

Disorder Aliases PubMed IDs
sialuria
  • sialic acid storage disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ST3GAL6

Genetic Association Database (GAD)
ST3GAL6
Human Genome Epidemiology (HuGE) Navigator
ST3GAL6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ST3GAL6
genes like me logo Genes that share disorders with ST3GAL6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST3GAL6 Gene

Publications for ST3GAL6 Gene

  1. Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids. (PMID: 10206952) Okajima T. … Furukawa K. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewis x epitopes in the human bronchial mucosa. (PMID: 17944600) Groux-Degroote S. … Delannoy P. (Biochem. J. 2008) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma. (PMID: 25061176) Glavey S.V. … O'Dwyer M.E. (Blood 2014) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for ST3GAL6 Gene

Sources for ST3GAL6 Gene

Content