Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ST3GAL6 Gene

Aliases for ST3GAL6 Gene

  • ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 6 2 3 5
  • CMP-NeuAc:Beta-Galactoside Alpha-2,3-Sialyltransferase VI 3 4
  • Sialyltransferase 10 (Alpha-2,3-Sialyltransferase VI) 2 3
  • ST3GALVI 3 4
  • SIAT10 3 4
  • Type 2 Lactosamine Alpha-2,3-Sialyltransferase 3
  • Alpha2,3-Sialyltransferase ST3Gal VI 3
  • Sialyltransferase 10 4
  • EC 2.4.99.9 56
  • EC 2.4.99.- 4
  • ST3Gal VI 4
  • EC 2.4.99 56

External Ids for ST3GAL6 Gene

Previous HGNC Symbols for ST3GAL6 Gene

  • SIAT10

Previous GeneCards Identifiers for ST3GAL6 Gene

  • GC03P099935
  • GC03P098451
  • GC03P095823

Summaries for ST3GAL6 Gene

Entrez Gene Summary for ST3GAL6 Gene

  • The protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for cell-to-cell recognition and a blood group antigen. [provided by RefSeq, Apr 2016]

GeneCards Summary for ST3GAL6 Gene

ST3GAL6 (ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 6) is a Protein Coding gene. Diseases associated with ST3GAL6 include Sialuria. Among its related pathways are Keratan sulfate/keratin metabolism and Glycosaminoglycan metabolism. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity and beta-galactoside alpha-2,3-sialyltransferase activity. An important paralog of this gene is ST3GAL4.

UniProtKB/Swiss-Prot for ST3GAL6 Gene

  • Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1.

Additional gene information for ST3GAL6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST3GAL6 Gene

Genomics for ST3GAL6 Gene

GeneHancer (GH) Regulatory Elements for ST3GAL6 Gene

Promoters and enhancers for ST3GAL6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I098731 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 559 +0.8 818 3.1 HDGF FOXA2 ARID4B DMAP1 ZNF48 YY1 ZNF213 ATF7 RUNX3 SP3 ST3GAL6-AS1 ST3GAL6 OR5K2 DCBLD2 GC03P098755
GH03I098762 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 572.9 +32.3 32258 3.6 MAX BATF RAD21 GABPA JUND ZNF316 ATF3 POLR2A NBN HNF4A ST3GAL6 ST3GAL6-AS1 CPOX GC03P098755 PDLIM1P4
GH03I098730 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 562.5 -1.6 -1621 0.8 HDGF PKNOX1 JUN BACH1 EBF1 BATF IRF4 NFATC1 ZNF143 ATF7 ST3GAL6 ST3GAL6-AS1 GC03M098711
GH03I098782 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 33.9 +52.6 52616 4.9 FOXA2 MLX ARID4B ETS1 YY1 ATF7 FOS RUNX3 RXRA SP5 ST3GAL6 DCBLD2 ST3GAL6-AS1 CPOX OR5K4 PDLIM1P4 RNU6-26P GC03M098805 GC03P098755
GH03I098776 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 30.6 +46.4 46432 4.7 FOXA2 MLX ARID4B DMAP1 YY1 RUNX3 RXRA SP5 NFYC ZHX2 ST3GAL6 DCBLD2 ST3GAL6-AS1 CPOX PDLIM1P4 GC03P098755
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ST3GAL6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ST3GAL6 gene promoter:

Genomic Locations for ST3GAL6 Gene

Genomic Locations for ST3GAL6 Gene
chr3:98,732,236-98,821,201
(GRCh38/hg38)
Size:
88,966 bases
Orientation:
Plus strand
chr3:98,451,080-98,540,045
(GRCh37/hg19)

Genomic View for ST3GAL6 Gene

Genes around ST3GAL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST3GAL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST3GAL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST3GAL6 Gene

Proteins for ST3GAL6 Gene

  • Protein details for ST3GAL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y274-SIA10_HUMAN
    Recommended name:
    Type 2 lactosamine alpha-2,3-sialyltransferase
    Protein Accession:
    Q9Y274
    Secondary Accessions:
    • B2RCH2
    • B3KMI1
    • D3DN39
    • F8W6U0

    Protein attributes for ST3GAL6 Gene

    Size:
    331 amino acids
    Molecular mass:
    38214 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ST3GAL6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ST3GAL6 Gene

Selected DME Specific Peptides for ST3GAL6 Gene

Q9Y274:
  • QKPKHPTTGIIA
  • YHNVTAEQLFLKDIIEKN
  • RLFYPES
  • LSKLQSCDL
  • YGSDKFDLPYGM
  • IDSYDVIIRMNNGPVLGHEEEVG
  • CVVVGNGGVLKNKTLG
  • EVHLAGFKYNF
  • PALNLIYKPYQIRILDP
  • GYLVAIFLS
  • AIFLSAVFLYYVLHCILW
  • HQFHPFLCAA
  • CVVVGNG
  • SPLHYYGNATMSLM

Post-translational modifications for ST3GAL6 Gene

  • Glycosylation at isoforms=129, isoforms=2181, isoforms=2282, isoforms=2295, isoforms=2308, and posLast=327327

Domains & Families for ST3GAL6 Gene

Gene Families for ST3GAL6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ST3GAL6 Gene

Suggested Antigen Peptide Sequences for ST3GAL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y274

UniProtKB/Swiss-Prot:

SIA10_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST3GAL6: view

Function for ST3GAL6 Gene

Molecular function for ST3GAL6 Gene

UniProtKB/Swiss-Prot Function:
Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1.

Enzyme Numbers (IUBMB) for ST3GAL6 Gene

Phenotypes From GWAS Catalog for ST3GAL6 Gene

Gene Ontology (GO) - Molecular Function for ST3GAL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity TAS --
GO:0008373 sialyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity IDA 10206952
genes like me logo Genes that share ontologies with ST3GAL6: view
genes like me logo Genes that share phenotypes with ST3GAL6: view

Animal Models for ST3GAL6 Gene

MGI Knock Outs for ST3GAL6:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ST3GAL6 Gene

Localization for ST3GAL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST3GAL6 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST3GAL6 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for ST3GAL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,NAS 10206952
GO:0070062 extracellular exosome HDA,IDA 19199708
genes like me logo Genes that share ontologies with ST3GAL6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ST3GAL6 Gene

Pathways & Interactions for ST3GAL6 Gene

genes like me logo Genes that share pathways with ST3GAL6: view

Gene Ontology (GO) - Biological Process for ST3GAL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IDA 10206952
GO:0006486 protein glycosylation IEA --
GO:0006664 glycolipid metabolic process IDA 10206952
GO:0009311 oligosaccharide metabolic process IDA 10206952
GO:0018146 keratan sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with ST3GAL6: view

No data available for SIGNOR curated interactions for ST3GAL6 Gene

Drugs & Compounds for ST3GAL6 Gene

(1) Drugs for ST3GAL6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine monophosphate Experimental Pharma 0

(5) Additional Compounds for ST3GAL6 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-Acetylneuraminate
  • CMP-N-Acylneuraminate
  • CMP-NeuNAc
  • Cytidine 5'-monophosphate N-acetylneuraminic acid
  • Cytidine Monophosphate N-Acetylneuraminate
22-12-8
Sialyl-Lewis X
  • 3'-Sialyl-Lewis X
  • 3'-Sialyl-Lewis-X tetrasaccharide
  • 3'-SLeX
  • a-NeuNAc-(2>3)-b-D-Gal-(1>4)(a-L-Fuc-[1>3])-D-GlcNAc
  • alpha-NeuNAc-(2>3)-beta-delta-Gal-(1>4)(a-L-Fuc-[1>3])-delta-GlcNAc
98603-84-0
genes like me logo Genes that share compounds with ST3GAL6: view

Transcripts for ST3GAL6 Gene

Unigene Clusters for ST3GAL6 Gene

ST3 beta-galactoside alpha-2,3-sialyltransferase 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL6 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
SP7: - - - -
SP8: - - - - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - -
SP11: -
SP12:
SP13: - - -
SP14: - - - - -
SP15:

ExUns: 16 ^ 17 ^ 18a · 18b · 18c · 18d · 18e · 18f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for ST3GAL6 Gene

GeneLoc Exon Structure for
ST3GAL6
ECgene alternative splicing isoforms for
ST3GAL6

Expression for ST3GAL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST3GAL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST3GAL6 Gene

This gene is overexpressed in Liver (x5.6) and Heart - Left Ventricle (x4.7).

Protein differential expression in normal tissues from HIPED for ST3GAL6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.3), Serum (27.4), and Placenta (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ST3GAL6 Gene



Protein tissue co-expression partners for ST3GAL6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ST3GAL6 Gene:

ST3GAL6

SOURCE GeneReport for Unigene cluster for ST3GAL6 Gene:

Hs.148716

mRNA Expression by UniProt/SwissProt for ST3GAL6 Gene:

Q9Y274-SIA10_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ST3GAL6 Gene

  • Liver(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ST3GAL6: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ST3GAL6 Gene

Orthologs for ST3GAL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST3GAL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST3GAL6 34 33
  • 99.6 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ST3GAL6 34 33
  • 92.85 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ST3GAL6 33 34
  • 89.53 (n)
mouse
(Mus musculus)
Mammalia St3gal6 16 34 33
  • 81.46 (n)
rat
(Rattus norvegicus)
Mammalia St3gal6 33
  • 80.36 (n)
oppossum
(Monodelphis domestica)
Mammalia ST3GAL6 34
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 31 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ST3GAL6 34 33
  • 69.1 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST3GAL6 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st3gal6 33
  • 59.45 (n)
African clawed frog
(Xenopus laevis)
Amphibia st3Gal-VI 33
zebrafish
(Danio rerio)
Actinopterygii st3gal5l 34
  • 26 (a)
ManyToMany
Species where no ortholog for ST3GAL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST3GAL6 Gene

ENSEMBL:
Gene Tree for ST3GAL6 (if available)
TreeFam:
Gene Tree for ST3GAL6 (if available)

Paralogs for ST3GAL6 Gene

genes like me logo Genes that share paralogs with ST3GAL6: view

Variants for ST3GAL6 Gene

Sequence variations from dbSNP and Humsavar for ST3GAL6 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000049376 -- 98,730,772(+) C/T upstream_transcript_variant
rs1000067078 -- 98,784,633(+) G/A intron_variant
rs1000103923 -- 98,731,867(+) C/T upstream_transcript_variant
rs1000117681 -- 98,732,317(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000127715 -- 98,736,427(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ST3GAL6 Gene

Variant ID Type Subtype PubMed ID
nsv470783 CNV loss 18288195
nsv591065 CNV gain 21841781

Variation tolerance for ST3GAL6 Gene

Residual Variation Intolerance Score: 55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.70; 66.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST3GAL6 Gene

Human Gene Mutation Database (HGMD)
ST3GAL6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST3GAL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST3GAL6 Gene

Disorders for ST3GAL6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ST3GAL6 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
sialuria
  • sialuria, french type
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ST3GAL6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ST3GAL6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST3GAL6 Gene

Publications for ST3GAL6 Gene

  1. Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids. (PMID: 10206952) Okajima T … Furukawa K (The Journal of biological chemistry 1999) 2 3 4 22 58
  2. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J … ENGAGE Consortium (PLoS genetics 2010) 3 44 58
  3. IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewisx epitopes in the human bronchial mucosa. (PMID: 17944600) Groux-Degroote S … Delannoy P (The Biochemical journal 2008) 3 22 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ST3GAL6 Gene

Sources for ST3GAL6 Gene

Content
Loading form....