ST3GAL6 Gene

Aliases
for ST3GAL6 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC03P099935 GC03P095823

Summaries
for ST3GAL6 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for ST3GAL6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000003.11  NT_005612.17  NC_018914.2  

SwitchGear Promoter luciferase reporter plasmid: ST3GAL6 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST3GAL6

ST3GAL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P098451:  view genomic region     (about GC identifiers)

Proteins
for ST3GAL6 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for ST3GAL6: NX_Q9Y274

Explore proteomics data for ST3GAL6 at MOPED

Post-translational modifications: 

ST3GAL6 Human Recombinant Protein Products:

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	antibodies-online proteins for ST3GAL6 (6 products)
	antibodies-online peptides for ST3GAL6

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ST3GAL6 Assay Products:

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	antibodies-online kits for ST3GAL6 (8 products)

Domains /
Families
for ST3GAL6 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9Y274

Find genes that share domains with ST3GAL6           About GenesLikeMe

Function
for ST3GAL6 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Enzyme Numbers (IUBMB): EC 2.4.99.9² EC 2.4.99.-¹ EC 2.4.99²

     Gene Ontology (GO): 2 molecular function terms:    About this table

(inferred from 1 allele) (MGI details for St3gal6)

genOway: Develop your customized and physiologically relevant rodent model for ST3GAL6

miRNA Products:		miRTarBase miRNAs that target ST3GAL6: hsa-mir-215-5p (MIRT024498), hsa-mir-192-5p (MIRT026490)
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		Selected qRT-PCR Assays for microRNAs that regulate ST3GAL6 (see all 14):
		hsa-miR-1226 hsa-miR-27a hsa-miR-513a-5p hsa-miR-548e hsa-miR-548o hsa-miR-876-3p hsa-miR-1911* hsa-miR-21
		SwitchGear 3'UTR luciferase reporter plasmid: ST3GAL6 3' UTR sequence

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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ST3GAL6

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST3GAL6

Localization
for ST3GAL6 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
golgi apparatus	5
endoplasmic reticulum	2
extracellular	1

About this image

Gene Ontology (GO): 5 cellular component terms:    About this table

Pathways & Interactions
for ST3GAL6 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for ST3GAL6 About   (see all 8)   See pathways by source

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	SuperPath	Selected contained pathways About (see all per SuperPath)
1	Metabolism	Metabolism 0.38 Metabolic pathways 0.38
2	MPS VI - Maroteaux-Lamy syndrome	MPS VI - Maroteaux-Lamy syndrome 0.45 MPS IV - Morquio syndrome B 0.45 MPS IIIC - Sanfilippo syndrome C 0.45 MPS IX - Natowicz syndrome 0.45 MPS IIID - Sanfilippo syndrome D 0.45 MPS IV - Morquio syndrome A 0.45 MPS IIIA - Sanfilippo syndrome A 0.45 Mucopolysaccharidoses 0.45
3	Keratan sulfate/keratin metabolism	Keratan sulfate/keratin metabolism 0.85 Keratan sulfate biosynthesis 0.85
4	Pre-NOTCH Expression and Processing	Pre-NOTCH Expression and Processing 0.62 Pre-NOTCH Processing in Golgi 0.00
5	Signaling by NOTCH1 PEST Domain Mutants in Cancer	Signaling by NOTCH 0.64

3 Reactome Pathways for ST3GAL6

	Pre-NOTCH Processing in Golgi
	Sialic acid metabolism
	Keratan sulfate biosynthesis

2 Kegg Pathways  (Kegg details for ST3GAL6)

	Glycosphingolipid biosynthesis - lacto and neolacto series
	Metabolic pathways

Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

Drugs & Compounds
for ST3GAL6 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for ST3GAL6 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for ST3GAL6 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ST3GAL6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATTGTGAAGA

About this image

Kidney (Urinary System)    fully expand to see all 2 entries
Podocytes Podocyte Layer
Renal Vesicle
Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
Human embryonic stem cells (family)
Epithelial Cells
Podocytes Podocyte Layer
Blood (Hematopoietic System)
Granulocytes Peripheral Blood
Neural Tube (Nervous System)
Mesencephalic Floor Plate

Primer Products:		OriGene qPCR primer pairs and template standards for ST3GAL6 OriGene qSTAR qPCR primer pairs in human, mouse for ST3GAL6
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ST3GAL6
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST3GAL6

Orthologs
for ST3GAL6 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for ST3GAL6 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for ST3GAL6 gene

ST3GAL3²  ST6GALNAC1²  ST6GALNAC2²  ST3GAL1²  ST3GAL4²  ST3GAL2²  ST3GAL5²  

6 SIMAP similar genes for ST3GAL6 using alignment to 11 protein entries:     SIA10_HUMAN (see all proteins):

ST3GAL1    ST3GAL4    ST3GAL3    SIAT4C    ST3GAL5    ST3GalIII

Find genes that share paralogs with ST3GAL6           About GenesLikeMe

Genomic Variants
for ST3GAL6 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ST3GAL6 (see all 1229)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1470212961,2		--	98426468(+)	TATTAC/TCTCAC	2	--	us2k1		0	--	--	--	--
rs1168792581,2	C,F	--	98453548(+)	ACCTTT/CGAGGC	6	--	int1		1		EA	120
rs1868641871,2		--	98453636(+)	ATTGTA/TAATCG	6	--	int1		0	--	--	--	--
rs1129009721,2	C,F	--	98453733(+)	ACCTTA/GTGGGA	6	--	int1		2		CSA WA	120
rs1922827001,2		--	98453758(+)	TGCCAG/TGTTTC	6	--	int1		0	--	--	--	--
rs1489418871,2		--	98453777(+)	CCCTGA/GTAAGC	6	--	int1		0	--	--	--	--
rs1470306671,2		--	98453862(+)	GATCTA/GTTTAG	6	--	int1		0	--	--	--	--
rs1149659721,2	C,F	--	98453880(+)	TTTAGG/ATGATG	6	--	int1		1		NA	120
rs1476504521,2		--	98453909(+)	GAAGCA/CTGGAA	6	--	int1		0	--	--	--	--
rs2783731,2	C,F,A,H	--	98453951(+)	GTGTTT/CTCATA	6	--	int1		33		NA NS EA WA CSA	2921

HapMap Linkage Disequilibrium report for ST3GAL6 (98451080 - 98540045 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for ST3GAL6:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv470783	CNV	Loss	18288195
nsv877214	CNV	Gain	21882294

Human Gene Mutation Database (HGMD): ST3GAL6

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ST3GAL6

DNA2.0 Custom Variant and Variant Library Synthesis for ST3GAL6

Disorders / Diseases
for ST3GAL6 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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2 diseases for ST3GAL6

2 Novoseek inferred disease relationships for ST3GAL6 gene    About this table

Publications
for ST3GAL6 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids. (PubMed id 10206952)^{1, 2, 3, 9} Okajima T.... Furukawa K. (J. Biol. Chem. 1999)
2. Use of genome-wide expression data to mine the &quot;Gray Zone&quot; of GWA studies leads to novel candidate obesity genes. (PubMed id 20532202)^{1, 4} Naukkarinen J....Peltonen L. (PLoS Genet. 2010)
3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
5. IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewis x epitopes in the human bronchial mucosa. (PubMed id 17944600)^{1, 9} Groux-Degroote S.... Delannoy P. (Biochem. J. 2008)
6. Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands. (PubMed id 22700726)¹ Yang W.H....Sperandio M. (Blood 2012)
7. A fine-mapping study of 7 top scoring genes from a GWAS for major depressive disorder. (PubMed id 22649524)¹ Verbeek E.C....Heutink P. (PLoS ONE 2012)
8. Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers. (PubMed id 22025563)¹ Julien S....Burchell J.M. (Cancer Res. 2011)
9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
10. Differences in CD75s- and iso-CD75s-ganglioside content and altered mRNA expression of sialyltransferases ST6GAL1 and ST3GAL6 in human hepatocellular carcinomas and nontumoral liver tissues. (PubMed id 21147760)¹ Souady J....MA1thing J. (Glycobiology 2011)

External Searches for ST3GAL6 gene

Genome Databases showing ST3GAL6 gene

Other Databases showing ST3GAL6 gene

Specialized Databases showing ST3GAL6 gene

Products
for ST3GAL6 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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