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ST3GAL6 Gene

protein-coding   GIFtS: 59
GCID: GC03P098451

ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 6

(Previous name: sialyltransferase 10 (alpha-2,3-sialyltransferase VI))
(Previous symbol: SIAT10)
  See ST3GAL6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 61 2     EC 2.4.99.-3
SIAT101 2 3     ST3GalVI3
Sialyltransferase 10 (Alpha-2,3-Sialyltransferase VI)1 2     Sialyltransferase 103
CMP-NeuAc:Beta-Galactoside Alpha-2,3-Sialyltransferase VI2 3     ST3Gal VI3
ST3GALVI2 5     EC 2.4.998
Alpha2,3-Sialyltransferase ST3Gal VI2     EC 2.4.99.98
Type 2 Lactosamine Alpha-2,3-Sialyltransferase2     

External Ids:    HGNC: 180801   Entrez Gene: 104022   Ensembl: ENSG000000642257   OMIM: 6071565   UniProtKB: Q9Y2743   
ORGUL members:         

Export aliases for ST3GAL6 gene to outside databases

Previous GC identifers: GC03P099935 GC03P095823


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ST3GAL6 Gene:
The protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes
that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal
positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This
protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates
and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for
cell-to-cell recognition and a blood group antigen. Alternative splicing results in multiple transcript variants
that encode different protein isoforms. (provided by RefSeq, Sep 2012)

GeneCards Summary for ST3GAL6 Gene:
ST3GAL6 (ST3 beta-galactoside alpha-2,3-sialyltransferase 6) is a protein-coding gene. Diseases associated with ST3GAL6 include inflammatory breast carcinoma, and sialuria. GO annotations related to this gene include beta-galactoside alpha-2,3-sialyltransferase activity. An important paralog of this gene is ST3GAL3.

UniProtKB/Swiss-Prot: SIA10_HUMAN, Q9Y274
Function: Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a
alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a
restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide
and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ST3GAL6 gene promoter:
         SREBP-1c   RelA   NF-kappaB   GATA-1   SREBP-1b   E2F   SREBP-1a   E2F-1   NF-kappaB1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidST3GAL6 promoter sequence
   Search Chromatin IP Primers for ST3GAL6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST3GAL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q12.1   Ensembl cytogenetic band:  3q12.1   HGNC cytogenetic band: 3q12.2

ST3GAL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST3GAL6 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P098451:  view genomic region     (about GC identifiers)

Start:
98,451,080 bp from pter      End:
98,540,045 bp from pter
Size:
88,966 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SIA10_HUMAN, Q9Y274 (See protein sequence)
Recommended Name: Type 2 lactosamine alpha-2,3-sialyltransferase  
Size: 331 amino acids; 38214 Da
Secondary accessions: B2RCH2 B3KMI1 D3DN39 F8W6U0
Alternative splicing: 2 isoforms:  Q9Y274-1   Q9Y274-2   

Explore the universe of human proteins at neXtProt for ST3GAL6: NX_Q9Y274

Explore proteomics data for ST3GAL6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn129, Asn181, Asn282, Asn295, Asn308, Asn327
  • Selected DME Specific Peptides for ST3GAL6 (Q9Y274) (see all 14)
     RLFYPES  CVVVGNG  LSKLQSCDL  GYLVAIFLS 


    See ST3GAL6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001258071.1  NP_001258074.1  NP_001258075.1  NP_001258076.1  NP_001258077.1  NP_006091.1  

    ENSEMBL proteins: 
     ENSP00000417376   ENSP00000419209   ENSP00000419690   ENSP00000420047   ENSP00000417584  
     ENSP00000418896   ENSP00000418581   ENSP00000417109   ENSP00000420474   ENSP00000418650  
     ENSP00000420693   ENSP00000417201   ENSP00000419987   ENSP00000419202   ENSP00000377717  
     ENSP00000265261  
    Reactome Protein details: Q9Y274

    ST3GAL6 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ST3GAL6 

     
    antibodies-online proteins for ST3GAL6 (6 products) 

     
    antibodies-online peptides for ST3GAL6

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    antibodies-online antibodies for ST3GAL6 (12 products) 

    ST3GAL6 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ST3G: Sialyltransferases

    2 InterPro protein domains:
     IPR001675 Glyco_trans_29
     IPR012163 Sialyl_trans

    Graphical View of Domain Structure for InterPro Entry Q9Y274

    ProtoNet protein and cluster: Q9Y274

    1 Blocks protein domain: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIA10_HUMAN, Q9Y274
    Similarity: Belongs to the glycosyltransferase 29 family


    Find genes that share domains with ST3GAL6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIA10_HUMAN, Q9Y274
    Function: Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a
    alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a
    restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide
    and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1

         Enzyme Numbers (IUBMB): EC 2.4.99.92 EC 2.4.99.-1 EC 2.4.992

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008373sialyltransferase activity ----
    GO:0052798beta-galactoside alpha-2,3-sialyltransferase activity IDA10206952
         
    Find genes that share ontologies with ST3GAL6           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ST3GAL6:
     Increased cell death in breast 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for St3gal6):
     cellular  hematopoietic system  immune system 

    Find genes that share phenotypes with ST3GAL6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out St3gal6tm1.1Jxm for ST3GAL6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ST3GAL6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ST3GAL6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ST3GAL6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ST3GAL6

    miRNA
    Products:
        
    miRTarBase miRNAs that target ST3GAL6:
    hsa-mir-215-5p (MIRT024498), hsa-mir-192-5p (MIRT026490)

    Block miRNA regulation of human, mouse, rat ST3GAL6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ST3GAL6 (see all 14):
    hsa-miR-1226 hsa-miR-27a hsa-miR-513a-5p hsa-miR-548e hsa-miR-548o hsa-miR-876-3p hsa-miR-1911* hsa-miR-21
    SwitchGear 3'UTR luciferase reporter plasmidST3GAL6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ST3GAL6
    Predesigned siRNA for gene silencing in human, mouse, rat ST3GAL6

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ST3GAL6 (NM_006100)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST3GAL6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST3GAL6
    Addgene plasmids for ST3GAL6 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST3GAL6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIA10_HUMAN, Q9Y274: Golgi apparatus membrane; Single-pass type II membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    endoplasmic reticulum2
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus ----
    GO:0016021integral component of membrane NAS10206952
    GO:0030173integral component of Golgi membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with ST3GAL6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ST3GAL6 About   (see all 8)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    2MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    3Keratan sulfate/keratin metabolism
    Keratan sulfate/keratin metabolism0.85
    Keratan sulfate biosynthesis0.85
    4Pre-NOTCH Expression and Processing
    Pre-NOTCH Expression and Processing0.62
    Pre-NOTCH Processing in Golgi0.00
    5Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Signaling by NOTCH0.64


    Find genes that share SuperPaths with ST3GAL6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for ST3GAL6
        Pre-NOTCH Processing in Golgi
    Sialic acid metabolism
    Keratan sulfate biosynthesis


    2 Kegg Pathways  (Kegg details for ST3GAL6):
        Glycosphingolipid biosynthesis - lacto and neolacto series
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ST3GAL6
    Interactions:

        Search GeneGlobe Interaction Network for ST3GAL6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ST3GAL6 (ENSP000003777174) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    B4GALT1ENSP000003690554STRING: ENSP00000369055
    CHST6ENSP000003289834STRING: ENSP00000328983
    FUT1ENSP000003120214STRING: ENSP00000312021
    FUT4ENSP000003516024STRING: ENSP00000351602
    FUT6ENSP000002869554STRING: ENSP00000286955
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006464cellular protein modification process IDA10206952
    GO:0006486protein glycosylation IEA--
    GO:0006664glycolipid metabolic process IDA10206952
    GO:0009311oligosaccharide metabolic process IDA10206952

    Find genes that share ontologies with ST3GAL6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ST3GAL6 (SIA10)

    3 HMDB Compounds for ST3GAL6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cytidine monophosphate5'-CMP (see all 14)63-37-6--
    Cytidine monophosphate N-acetylneuraminic acidCMP-N-acetylneuraminate (see all 6)22-12-8--
    Sialyl-Lewis X3'-Sialyl-Lewis X (see all 8)98603-84-0--

    3 Novoseek inferred chemical compound relationships for ST3GAL6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gal(beta1-3)galnac 73.7 1 9628888 (1)
    sialic acid 72.5 1 9182658 (1)
    asialo gm1 70.2 1 12716912 (1)



    Find genes that share compounds with ST3GAL6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ST3GAL6 gene (6 alternative transcripts): 
    NM_001271142.1  NM_001271145.1  NM_001271146.1  NM_001271147.1  NM_001271148.1  NM_006100.3  

    Unigene Cluster for ST3GAL6:

    ST3 beta-galactoside alpha-2,3-sialyltransferase 6
    Hs.148716  [show with all ESTs]
    Unigene Representative Sequence: CR749468
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000489112 ENST00000483910 ENST00000460774 ENST00000469105(uc003dsy.3 uc003dsz.3 uc003dta.3)
    ENST00000466482 ENST00000462152 ENST00000486249 ENST00000497008 ENST00000486334
    ENST00000480133 ENST00000497621(uc003dtc.3 uc010hpd.3) ENST00000465004
    ENST00000476833 ENST00000468553 ENST00000490684 ENST00000485391 ENST00000495376
    ENST00000492254
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    hsa-miR-1226 hsa-miR-27a hsa-miR-513a-5p hsa-miR-548e hsa-miR-548o hsa-miR-876-3p hsa-miR-1911* hsa-miR-21
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    Additional mRNA sequence: 

    AB022918.1 AF119391.1 AK001922.1 AK315111.1 BC001266.2 BC012092.1 BC023312.1 CR749468.1 

    22 DOTS entries:

    DT.91648904  DT.100780429  DT.441821  DT.91723321  DT.75160594  DT.92048988  DT.100654969  DT.100780433 
    DT.40292564  DT.442867  DT.99999677  DT.100780430  DT.100780431  DT.120914520  DT.40272715  DT.95200021 
    DT.99999477  DT.120914582  DT.120914610  DT.75110962  DT.91971078  DT.92419998 

    Selected AceView cDNA sequences (see all 155):

    BX092348 AA884052 AI955457 AB022918 AI471207 CA396843 NM_006100 BC001266 
    BE465534 N91882 CR607538 BF589596 CA308014 AI478510 BM449842 BE348317 
    AI984377 BU188066 Z43713 BC023312 BU165940 AI056701 BF447500 CR624848 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL6 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^
    SP1:                                -     -     -     -     -     -     -                             -           -           -     -     -                     
    SP2:                                                        -     -     -                       -     -           -           -     -     -                     
    SP3:                                -     -     -     -     -     -     -                       -     -           -           -     -     -                     
    SP4:                                -     -     -     -     -     -     -                             -           -           -     -     -     -     -         
    SP5:                                                  -     -     -     -                       -     -           -           -     -     -                     

    ExUns: 16 ^ 17 ^ 18a · 18b · 18c · 18d · 18e · 18f
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for ST3GAL6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ST3GAL6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGTGAAGA
    ST3GAL6 Expression
    About this image


    ST3GAL6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Podocytes Podocyte Layer
             Renal Vesicle
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Epithelial Cells
             Podocytes Podocyte Layer
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Neural Tube (Nervous System)
             Mesencephalic Floor Plate
    ST3GAL6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ST3GAL6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.148716

    UniProtKB/Swiss-Prot: SIA10_HUMAN, Q9Y274
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ST3GAL6 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St3gal61 , 5 ST3 beta-galactoside alpha-2,3-sialyltransferase 61, 5 81.46(n)1
    74.47(a)1
      16 (34.58 cM)5
    546131  NM_018784.21  NP_061254.11 
     584681255 
    chicken
    (Gallus gallus)
    Aves ST3GAL61 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 69.1(n)
    63.83(a)
      395138  NM_204479.1  NP_989810.1 
    lizard
    (Anolis carolinensis)
    Reptilia ST3GAL66
    ST3 beta-galactoside alpha-2,3-sialyltransferase 6...
    55(a)
    1 ↔ 1
    3(174911192-174949257)
    African clawed frog
    (Xenopus laevis)
    Amphibia st3Gal-VI2 alpha2,3-sialyltransferase 72.66(n)    AJ585766.1 
    zebrafish
    (Danio rerio)
    Actinopterygii st3gal5l6
    ST3 beta-galactoside alpha-2,3-sialyltransferase 5...
    26(a)
    many ↔ many
    13(41328377-41338923) ENSDARG00000039064


    ENSEMBL Gene Tree for ST3GAL6 (if available)
    TreeFam Gene Tree for ST3GAL6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ST3GAL6 gene
    ST3GAL32  ST6GALNAC12  ST6GALNAC22  ST3GAL12  ST3GAL42  ST3GAL22  ST3GAL52  
    6 SIMAP similar genes for ST3GAL6 using alignment to 11 protein entries:     SIA10_HUMAN (see all proteins):
    ST3GAL1    ST3GAL4    ST3GAL3    SIAT4C    ST3GAL5    ST3GalIII

    Find genes that share paralogs with ST3GAL6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ST3GAL6 (see all 1229)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1470212961,2
    --98426468(+) TATTAC/TCTCAC 2 -- us2k10--------
    rs1168792581,2
    C,F--98453548(+) ACCTTT/CGAGGC 6 -- int11Minor allele frequency- C:0.02EA 120
    rs1868641871,2
    --98453636(+) ATTGTA/TAATCG 6 -- int10--------
    rs1129009721,2
    C,F--98453733(+) ACCTTA/GTGGGA 6 -- int12Minor allele frequency- G:0.05CSA WA 120
    rs1922827001,2
    --98453758(+) TGCCAG/TGTTTC 6 -- int10--------
    rs1489418871,2
    --98453777(+) CCCTGA/GTAAGC 6 -- int10--------
    rs1470306671,2
    --98453862(+) GATCTA/GTTTAG 6 -- int10--------
    rs1149659721,2
    C,F--98453880(+) TTTAGG/ATGATG 6 -- int11Minor allele frequency- A:0.02NA 120
    rs1476504521,2
    --98453909(+) GAAGCA/CTGGAA 6 -- int10--------
    rs2783731,2
    C,F,A,H--98453951(+) GTGTTT/CTCATA 6 -- int133Minor allele frequency- C:0.44NA NS EA WA CSA 2921

    HapMap Linkage Disequilibrium report for ST3GAL6 (98451080 - 98540045 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ST3GAL6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv470783CNV Loss18288195
    nsv877214CNV Gain21882294

    Human Gene Mutation Database (HGMD): ST3GAL6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ST3GAL6
    DNA2.0 Custom Variant and Variant Library Synthesis for ST3GAL6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607156    OMIM disorders: --

    2 diseases for ST3GAL6:    
    About MalaCards
    inflammatory breast carcinoma    sialuria


    Find genes that share disorders with ST3GAL6           About GenesLikeMe

    2 Novoseek inferred disease relationships for ST3GAL6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast carcinoma 17.7 1 10561455 (1)
    carcinoma 1.99 1 11389097 (1)

    Genetic Association Database (GAD): ST3GAL6
    Human Genome Epidemiology (HuGE) Navigator: ST3GAL6 (1 document)

    Export disorders for ST3GAL6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ST3GAL6 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with ST3GAL6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids. (PubMed id 10206952)1, 2, 3, 9 Okajima T.... Furukawa K. (J. Biol. Chem. 1999)
    2. Use of genome-wide expression data to mine the &quot;Gray Zone&quot; of GWA studies leads to novel candidate obesity genes. (PubMed id 20532202)1, 4 Naukkarinen J....Peltonen L. (PLoS Genet. 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewis x epitopes in the human bronchial mucosa. (PubMed id 17944600)1, 9 Groux-Degroote S.... Delannoy P. (Biochem. J. 2008)
    6. Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands. (PubMed id 22700726)1 Yang W.H....Sperandio M. (Blood 2012)
    7. A fine-mapping study of 7 top scoring genes from a GWAS for major depressive disorder. (PubMed id 22649524)1 Verbeek E.C....Heutink P. (PLoS ONE 2012)
    8. Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers. (PubMed id 22025563)1 Julien S....Burchell J.M. (Cancer Res. 2011)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. Differences in CD75s- and iso-CD75s-ganglioside content and altered mRNA expression of sialyltransferases ST6GAL1 and ST3GAL6 in human hepatocellular carcinomas and nontumoral liver tissues. (PubMed id 21147760)1 Souady J....MA1thing J. (Glycobiology 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10402 HGNC: 18080 AceView: SIAT10 Ensembl:ENSG00000064225 euGenes: HUgn10402
    ECgene: ST3GAL6 Kegg: 10402 H-InvDB: ST3GAL6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ST3GAL6 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST3GAL6
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_627

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ST3GAL6 gene:
    Search GeneIP for patents involving ST3GAL6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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