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Aliases for ST3GAL5 Gene

Aliases for ST3GAL5 Gene

  • ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 5 2 3 5
  • Sialyltransferase 9 (CMP-NeuAc:Lactosylceramide Alpha-2,3-Sialyltransferase; GM3 Synthase) 2 3
  • CMP-NeuAc:Lactosylceramide Alpha-2,3-Sialyltransferase 3 4
  • Ganglioside GM3 Synthase 3 4
  • EC 4 61
  • ST3Gal V 3 4
  • ST3GalV 3 4
  • SIAT9 3 4
  • ST3 Beta-Galactoside Alpha-23-Sialyltransferase 5 3
  • Lactosylceramide Alpha-2,3-Sialyltransferase 3
  • Alpha 2,3-Sialyltransferase V 3
  • Sialyltransferase 9 4
  • GM3 Synthase 3
  • SIATGM3S 3
  • SPDRS 3
  • SATI 3

External Ids for ST3GAL5 Gene

Previous HGNC Symbols for ST3GAL5 Gene

  • SIAT9

Previous GeneCards Identifiers for ST3GAL5 Gene

  • GC02M085978
  • GC02M085919
  • GC02M086066
  • GC02M085963

Summaries for ST3GAL5 Gene

Entrez Gene Summary for ST3GAL5 Gene

  • Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST3GAL5 Gene

ST3GAL5 (ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 5) is a Protein Coding gene. Diseases associated with ST3GAL5 include Amish Infantile Epilepsy Syndrome and In Situ Pulmonary Adenocarcinoma. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. GO annotations related to this gene include sialyltransferase activity and lactosylceramide alpha-2,3-sialyltransferase activity. An important paralog of this gene is ST3GAL3.

UniProtKB/Swiss-Prot for ST3GAL5 Gene

  • Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide).

Gene Wiki entry for ST3GAL5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST3GAL5 Gene

Genomics for ST3GAL5 Gene

Regulatory Elements for ST3GAL5 Gene

Enhancers for ST3GAL5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F085885 1.5 FANTOM5 ENCODE 10.9 +0.5 499 5.2 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A YY1 ZNF143 ZNF207 FOS LOC284950 ST3GAL5 RNU1-38P ST3GAL5-AS1 GNLY CAPG GC02M085888 GC02M085889 GC02P085883
GH02F085892 1.3 FANTOM5 Ensembl ENCODE 6.5 -4.9 -4893 3.5 RFX1 HLF BHLHE40 CHD1 SIN3A JUND CBX5 ATF3 POLR2A SMARCA4 ST3GAL5-AS1 ST3GAL5 POLR1A ENSG00000272564
GH02F084937 1.7 FANTOM5 Ensembl ENCODE 4.8 +946.3 946288 10.0 HDGF PKNOX1 ATF1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 LOC100996506 C2orf68 ST3GAL5 KCMF1 TMSB10 TRABD2A GC02M084928 GC02M084965
GH02F085933 1.6 FANTOM5 Ensembl ENCODE 4.6 -46.5 -46521 4.0 PKNOX1 ATF1 ARNT CREB3L1 SIN3A FEZF1 BRCA1 YY1 ELK1 GATA2 LOC284950 IMMT ENSG00000273080 POLR1A MRPL35 ST3GAL5 GC02P085952 ENSG00000272564
GH02F085920 1.1 Ensembl ENCODE 4.4 -33.0 -32980 2.0 HDAC1 TBL1XR1 RAD21 YY1 GATA2 FOS CREM ZNF680 NCOA1 JUNB SNORD94 LOC284950 RNU1-38P MAT2A ST3GAL5-AS1 ST3GAL5 ENSG00000272564 GC02P085952
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ST3GAL5 on UCSC Golden Path with GeneCards custom track

Promoters for ST3GAL5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000593832 234 3201 ATF1 PKNOX1 WRNIP1 ARID4B SIN3A ZNF48 YY1 GLIS2 ZNF143 ZNF207

Genomic Location for ST3GAL5 Gene

85,839,144 bp from pter
85,889,034 bp from pter
49,891 bases
Minus strand

Genomic View for ST3GAL5 Gene

Genes around ST3GAL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST3GAL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST3GAL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST3GAL5 Gene

Proteins for ST3GAL5 Gene

  • Protein details for ST3GAL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lactosylceramide alpha-2,3-sialyltransferase
    Protein Accession:
    Secondary Accessions:
    • B3KM82
    • D6W5L9
    • O94902
    • Q53QU1
    • Q6NZX4
    • Q6YFL1

    Protein attributes for ST3GAL5 Gene

    418 amino acids
    Molecular mass:
    47990 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD14634.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF66146.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ89463.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAY24147.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA33950.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ST3GAL5 Gene


neXtProt entry for ST3GAL5 Gene

Selected DME Specific Peptides for ST3GAL5 Gene


Post-translational modifications for ST3GAL5 Gene

Antibody Products

  • Abcam antibodies for ST3GAL5

Domains & Families for ST3GAL5 Gene

Gene Families for ST3GAL5 Gene

Protein Domains for ST3GAL5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 29 family.
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST3GAL5: view

Function for ST3GAL5 Gene

Molecular function for ST3GAL5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide).

Enzyme Numbers (IUBMB) for ST3GAL5 Gene

Gene Ontology (GO) - Molecular Function for ST3GAL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity TAS --
GO:0004513 neolactotetraosylceramide alpha-2,3-sialyltransferase activity TAS 9822625
GO:0008373 sialyltransferase activity TAS 10092602
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ST3GAL5: view
genes like me logo Genes that share phenotypes with ST3GAL5: view

Human Phenotype Ontology for ST3GAL5 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ST3GAL5 Gene

MGI Knock Outs for ST3GAL5:

Animal Model Products

  • Taconic Biosciences Mouse Models for ST3GAL5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for ST3GAL5 Gene

Localization for ST3GAL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST3GAL5 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST3GAL5 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
cytosol 2
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ST3GAL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0005887 integral component of plasma membrane TAS 9822625
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS 10092602
genes like me logo Genes that share ontologies with ST3GAL5: view

Pathways & Interactions for ST3GAL5 Gene

genes like me logo Genes that share pathways with ST3GAL5: view

Gene Ontology (GO) - Biological Process for ST3GAL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001574 ganglioside biosynthetic process NAS 9822625
GO:0005975 carbohydrate metabolic process TAS 9822625
GO:0006486 protein glycosylation IEA --
GO:0006688 glycosphingolipid biosynthetic process TAS 10092602
GO:0009311 oligosaccharide metabolic process IBA --
genes like me logo Genes that share ontologies with ST3GAL5: view

No data available for SIGNOR curated interactions for ST3GAL5 Gene

Drugs & Compounds for ST3GAL5 Gene

(1) Drugs for ST3GAL5 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
99mTc-14 F7 Mab Investigational Pharma Target 0

(80) Additional Compounds for ST3GAL5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytidine monophosphate
  • 5'-CMP
  • 5-Cytidylate
  • 5-Cytidylic acid
  • CMP
  • Cytidine 5'-monophosphate
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-Acetylneuraminate
  • CMP-N-Acylneuraminate
  • CMP-NeuNAc
  • Cytidine 5'-monophosphate N-acetylneuraminic acid
  • Cytidine Monophosphate N-Acetylneuraminate
Ganglioside GA1 (d18:1/12:0)
  • Asialo ganglioside GM1a
  • Asialo GM1
  • Asialo GM1 ganglioside
  • Asialoganglioside G(M1) from bovine brain
  • Asialoganglioside GM1
Ganglioside GA1 (d18:1/16:0)
  • Asialo ganglioside GM1a
  • Asialo GM1
  • Asialo GM1 ganglioside
  • Asialoganglioside G(M1) from bovine brain
  • Asialoganglioside GM1
Ganglioside GA1 (d18:1/20:0)
  • Asialo ganglioside GM1a
  • Asialo GM1
  • Asialo GM1 ganglioside
  • Asialoganglioside G(M1) from bovine brain
  • Asialoganglioside GM1
genes like me logo Genes that share compounds with ST3GAL5: view

Transcripts for ST3GAL5 Gene

Unigene Clusters for ST3GAL5 Gene

ST3 beta-galactoside alpha-2,3-sialyltransferase 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ·
SP1: - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP7: - - - - - - - - -
SP8: - - -
SP9: - -
SP10: - - - -
SP11: - - -

ExUns: 14c · 14d

Relevant External Links for ST3GAL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ST3GAL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ST3GAL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ST3GAL5 Gene

This gene is overexpressed in Heart (61.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ST3GAL5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ST3GAL5 Gene:


SOURCE GeneReport for Unigene cluster for ST3GAL5 Gene:


mRNA Expression by UniProt/SwissProt for ST3GAL5 Gene:

Tissue specificity: Ubiquitous. High expression in brain, skeletal muscle, placenta, and testis.
genes like me logo Genes that share expression patterns with ST3GAL5: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ST3GAL5 Gene

Orthologs for ST3GAL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST3GAL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ST3GAL5 34 35
  • 99.26 (n)
(Canis familiaris)
Mammalia ST3GAL5 34 35
  • 89.63 (n)
(Bos Taurus)
Mammalia ST3GAL5 34 35
  • 85.33 (n)
(Rattus norvegicus)
Mammalia St3gal5 34
  • 84.37 (n)
(Mus musculus)
Mammalia St3gal5 34 16 35
  • 83.62 (n)
(Ornithorhynchus anatinus)
Mammalia ST3GAL5 35
  • 76 (a)
(Monodelphis domestica)
Mammalia ST3GAL5 35
  • 73 (a)
(Gallus gallus)
Aves ST3GAL5 34 35
  • 72.56 (n)
(Anolis carolinensis)
Reptilia ST3GAL5 35
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia st3gal5 34
  • 61.97 (n)
(Danio rerio)
Actinopterygii st3gal5 34 35
  • 53.06 (n)
Species where no ortholog for ST3GAL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST3GAL5 Gene

Gene Tree for ST3GAL5 (if available)
Gene Tree for ST3GAL5 (if available)

Paralogs for ST3GAL5 Gene

(5) SIMAP similar genes for ST3GAL5 Gene using alignment to 5 proteins: Pseudogenes for ST3GAL5 Gene

genes like me logo Genes that share paralogs with ST3GAL5: view

Variants for ST3GAL5 Gene

Sequence variations from dbSNP and Humsavar for ST3GAL5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs104893668 Pathogenic 85,844,542(-) GGGTA(C/T)GACTC intron-variant, nc-transcript-variant, reference, stop-gained
rs534438354 Pathogenic 85,840,338(+) GACTT(C/T)ATCGC nc-transcript-variant, reference, missense
rs771732955 Pathogenic 85,847,922(+) TCCTC(C/T)GCTTC nc-transcript-variant, reference, missense
rs149309844 Likely benign 85,847,875(+) ACATC(A/G)AACTG nc-transcript-variant, reference, synonymous-codon
rs149801673 Likely benign 85,840,342(+) TCATC(A/G)CACAG nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ST3GAL5 Gene

Variant ID Type Subtype PubMed ID
nsv1143942 CNV deletion 24896259

Variation tolerance for ST3GAL5 Gene

Residual Variation Intolerance Score: 54.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.28; 76.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ST3GAL5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST3GAL5 Gene

Disorders for ST3GAL5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ST3GAL5 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
amish infantile epilepsy syndrome
  • salt-and-pepper syndrome
in situ pulmonary adenocarcinoma
  • bronchioalveolar carcinoma
- elite association - COSMIC cancer census association via MalaCards


  • Amish infantile epilepsy syndrome (AIES) [MIM:609056]: An autosomal recessive, infantile-onset symptomatic epilepsy associated with developmental stagnation and blindness. {ECO:0000269 PubMed:15502825}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ST3GAL5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ST3GAL5: view

No data available for Genatlas for ST3GAL5 Gene

Publications for ST3GAL5 Gene

  1. Expression cloning and functional characterization of human cDNA for ganglioside GM3 synthase. (PMID: 9822625) Ishii A. … Saito M. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  3. Elevated mRNA level of hST6Gal I and hST3Gal V positively correlates with the high risk of pediatric acute leukemia. (PMID: 19709745) Mondal S. … Mandal C. (Leuk. Res. 2010) 3 22 64
  4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &amp;quot;hot-spot&amp;quot;. (PMID: 20628624) Johnatty S.E. … . (PLoS Genet. 2010) 3 46 64
  5. Ganglioside depletion and EGF responses of human GM3 synthase-deficient fibroblasts. (PMID: 18480157) Liu Y. … Ladisch S. (Glycobiology 2008) 3 22 64

Products for ST3GAL5 Gene

Sources for ST3GAL5 Gene

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