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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ST3GAL4 Gene

protein-coding   GIFtS: 56
GCID: GC11P126225

ST3 beta-galactoside alpha-2,3-sialyltransferase 4

(Previous name: sialyltransferase 4C (beta-galactosidase alpha-2,3-sialytransferase)...)
(Previous symbols: CGS23, SIAT4, NANTA3, SIAT4C)
 Explore 42 diseases affiliated with
ST3GAL4 via our new
 Human Malady Compendium 
Biological research products
for ST3GAL4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 41 2     ST3GalIV2 3
CGS231 2 3 5     FLJ118671
NANTA31 2 3 5     Alpha-3-N-Acetylneuraminyltransferase1
SIAT4C1 2 3 5     CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,3-Sialyltransferase 42
STZ1 2 3     Gal-NAc6S3
SIAT41 2 5     Gal-Beta-1,4-GalNAc-Alpha-2,3-Sialyltransferase1
SAT31 2     Sialyltransferase 4C (Beta-Galactoside Alpha-2,3-Sialytransferase)2
Sialyltransferase 4C (Beta-Galactosidase Alpha-2,3-Sialytransferase)1 2     EC 2.4.99.-3
Alpha 2,3-Sialyltransferase IV2 3     Gal-NAc6S3
Alpha 2,3-ST 42 3     Gal-Beta-1,4-GalNAc-Alpha-2,3-Sialyltransferase1
Beta-Galactoside Alpha-2,3-Sialyltransferase 42 3     Sialyltransferase 4C3
SAT-32 3     ST3Gal IV3
SIAT4-C2 3     EC 2.4.998
ST-42 3     EC 2.4.99.98
ST3GalA.22 3     

External Ids:    HGNC: 108641   Entrez Gene: 64842   Ensembl: ENSG000001100807   OMIM: 1042405   UniProtKB: Q112063   

Export aliases for ST3GAL4 gene to outside databases

Previous GC identifers: GC11P125732 GC11P122170


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ST3GAL4:
This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation.
The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product
may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: SIA4C_HUMAN, Q11206
Function: It may catalyze the formation of the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- or
NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc-sequences found in terminal carbohydrate groups of glycoproteins and glycolipids.
It may be involved in the biosynthesis of the sialyl Lewis X determinant. Also acts on the corresponding
1,3-galactosyl derivative

Gene Wiki entry for ST3GAL4


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ST3GAL4 gene promoter:
         TBP   Sp1   p53   AP-1   ATF-2   STAT5A   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ST3GAL4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ST3GAL4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST3GAL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q23-q24

ST3GAL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST3GAL4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P126225:  view genomic region     (about GC identifiers)

Start:
126,225,535 bp from pter      End:
126,310,239 bp from pter
Size:
84,705 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SIA4C_HUMAN, Q11206 (See protein sequence)
Recommended Name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4  
Size: 333 amino acids; 38045 Da
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted.
Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid
Secondary accessions: A8K6B2 O60497 Q96QQ9
Alternative splicing: 5 isoforms:  Q11206-1   Q11206-2   Q11206-3   Q11206-4   Q11206-5   

Explore the universe of human proteins at neXtProt for ST3GAL4: NX_Q11206

Post-translational modifications:

  • The soluble form derives from the membrane form by proteolytic processing1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q11206

  • 4 DME Specific Peptides for ST3GAL4 (Q11206)
     RLFYPES  DVVIRLN  CVVVGNG  NKKQTIHYYEQITLKSMAGSGHNVSQEA 

    ST3GAL4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001241686.1  NP_001241687.1  NP_001241688.1  NP_006269.1  

    ENSEMBL proteins: 
     ENSP00000433495   ENSP00000227495   ENSP00000432929   ENSP00000394354   ENSP00000433989  
     ENSP00000433318   ENSP00000432647   ENSP00000432424   ENSP00000434756   ENSP00000376437  
     ENSP00000436047   ENSP00000399444   ENSP00000434349   ENSP00000434668   ENSP00000431170  
     ENSP00000348451  
    Reactome Protein details: Q11206
    Human Recombinant Protein Products: 
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    Novus Biologicals ST3GAL4 Protein
    Novus Biologicals ST3GAL4 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ST3GAL4

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005576extracellular region IEA--
    GO:0030173integral to Golgi membrane IEA--
    GO:0032580Golgi cisterna membrane IEA--


    ST3GAL4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ST3GAL4


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ST3GAL4 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001675 Glyco_trans_29
     IPR012163 Sialyl_trans

    Graphical View of Domain Structure for InterPro Entry Q11206

    ProtoNet protein and cluster: Q11206

    1 Blocks protein family: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIA4C_HUMAN, Q11206
    Similarity: Belongs to the glycosyltransferase 29 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SIA4C_HUMAN, Q11206
    Function: It may catalyze the formation of the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- or
    NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc-sequences found in terminal carbohydrate groups of glycoproteins and glycolipids.
    It may be involved in the biosynthesis of the sialyl Lewis X determinant. Also acts on the corresponding
    1,3-galactosyl derivative
    Catalytic activity: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP +
    alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein

    Enzyme Numbers (IUBMB): EC 2.4.99.92 EC 2.4.99.-1 EC 2.4.992

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    hsa-miR-3163 hsa-miR-3651 hsa-miR-216b hsa-miR-548t hsa-miR-1468 hsa-miR-3121-3p hsa-miR-3649 hsa-miR-651
    SwitchGear 3'UTR luciferase reporter plasmidST3GAL4 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003836beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IEA--
    GO:0005515protein binding ----
    GO:0008373sialyltransferase activity ----
    GO:0047288monosialoganglioside sialyltransferase activity IEA--


    ST3GAL4 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out St3gal4tm1.1Jxm for ST3GAL4
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for St3gal4):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  no phenotypic analysis 

    ST3GAL4 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MPS IIIC - Sanfilippo syndrome C
    8/14 pathways (see all 14)
    MPS VI - Maroteaux-Lamy syndrome1.00
    MPS VII - Sly syndrome1.00
    MPS IIIC - Sanfilippo syndrome C1.00
    MPS IIIA - Sanfilippo syndrome A1.00
    MPS I - Hurler syndrome1.00
    MPS IIID - Sanfilippo syndrome D1.00
    Mucopolysaccharidoses1.00
    MPS IX - Natowicz syndrome1.00
    2N-glycan antennae elongation in the medial/trans-Golgi
    N-glycan antennae elongation in the medial/trans-Golgi1.00
    Transport to the Golgi and subsequent modification0.56
    N-Glycan antennae elongation0.75
    3Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation1.00
    Metabolism of proteins0.15
    Post-translational protein modification0.44
    4Keratan sulfate biosynthesis
    Keratan sulfate biosynthesis1.00
    Keratan sulfate/keratin metabolism0.84
    5Metabolism
    Metabolism1.00
    Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/30        Reactome Pathways for ST3GAL4 (see all 30)
        Pre-NOTCH Expression and Processing
    MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    Keratan sulfate/keratin metabolism


    2         Kegg Pathways  (Kegg details for ST3GAL4):
        Glycosphingolipid biosynthesis - lacto and neolacto series
    Metabolic pathways

    UniProtKB/Swiss-Prot: SIA4C_HUMAN, Q11206
    Pathway: Protein modification; protein glycosylation


    ST3GAL4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ST3GAL4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/34 Interacting proteins for ST3GAL4 (Q112063 ENSP000002274954) via UniProtKB, MINT, STRING, and/or I2D (see all 34)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD8BP109663, ENSP000003311724I2D: score=1 STRING: ENSP00000331172
    ARHGDIAP525653, ENSP000002693214I2D: score=2 STRING: ENSP00000269321
    B3GALT1ENSP000003037404STRING: ENSP00000303740
    B3GALT5ENSP000003433184STRING: ENSP00000343318
    CHST2ENSP000003079114STRING: ENSP00000307911
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006486protein glycosylation ----
    GO:0016266O-glycan processing TAS--
    GO:0018146keratan sulfate biosynthetic process TAS--
    GO:0018279protein N-linked glycosylation via asparagine TAS--


    ST3GAL4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ST3GAL4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ST3GAL4

    10/13 HMDB Compounds for ST3GAL4 (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cytidine monophosphate5'-CMP (see all 14)63-37-6--
    Cytidine monophosphate N-acetylneuraminic acidCMP-N-acetylneuraminate (see all 6)22-12-8--
    Ganglioside GM1 (18:1/12:0)1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17)104443-62-1--
    Ganglioside GM1 (18:1/16:0)1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17)104443-62-1--
    Ganglioside GM1 (18:1/18:0)1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17)104443-62-1--
    Ganglioside GM1 (18:1/20:0)1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17)104443-62-1--
    Ganglioside GM1 (18:1/22:0)1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17)104443-62-1--
    Ganglioside GM1 (18:1/9Z-18:1)1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17)104443-62-1--
    Ganglioside GM1 (d18:1/24:0)1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17)104443-62-1--
    Ganglioside GM1 (d18:1/24:1(15Z))1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17)104443-62-1--
    10/46 Novoseek chemical compound relationships for ST3GAL4 gene (see all 46)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    streptozotocin 95.1 938 14767489 (10), 17477963 (10), 7802703 (9), 8181671 (9) (see all 99)
    pugnac 72.4 12 11185566 (4), 15843043 (4)
    alloxan 67.7 26 11841791 (5), 9218749 (3), 11467412 (3), 17045574 (3) (see all 9)
    glucose 66.2 74 17439741 (3), 9823013 (3), 7747600 (2), 15146370 (2) (see all 50)
    chloroethylnitrosourea 64.8 6 1427592 (3), 7554086 (1)
    gal(beta1-3)galnac 59.5 3 7655169 (1), 10080950 (1)
    bcnu 57.6 47 7802703 (7), 2137022 (4), 1533174 (4), 8364924 (3) (see all 9)
    o6-methylguanine 54.4 5 7554086 (1), 8364924 (1), 1825618 (1), 7802703 (1)
    slex 54.2 3 17054948 (2), 15483269 (1)
    nicotinamide 51.1 17 12006365 (3), 9519717 (3), 14630571 (2), 19728971 (1) (see all 8)

    Search CenterWatch for drugs/clinical trials and news about ST3GAL4 / SIA4C 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ST3GAL4 gene (4 alternative transcripts): 
    NM_001254757.1  NM_001254758.1  NM_001254759.1  NM_006278.2  

    Unigene Cluster for ST3GAL4:

    ST3 beta-galactoside alpha-2,3-sialyltransferase 4
    Hs.591947  [show with all ESTs]
    Unigene Representative Sequence: AK128605
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000534733 ENST00000227495 ENST00000531217 ENST00000444328(uc001qds.3)
    ENST00000530591 ENST00000534083(uc001qdu.3) ENST00000528605 ENST00000526311
    ENST00000528858 ENST00000534452 ENST00000392669(uc021qry.1 uc001qdz.3)
    ENST00000526756 ENST00000526727(uc009zce.3) ENST00000449406 ENST00000532243(uc001qdw.3)
    ENST00000534457 ENST00000524834(uc001qdx.1) ENST00000524860

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    Additional cDNA sequence: 

    AB009393.1 AF035249.1 AF516602.1 AF516603.1 AF516604.1 AF525084.1 AK128605.1 AK291577.1 
    AK314738.1 AY040826.1 BC010645.1 CR456858.1 L23767.1 X74570.1 

    24 DOTS entries:

    DT.443842  DT.100845793  DT.95112531  DT.120722835  DT.100845789  DT.95156400  DT.91754260  DT.95156404 
    DT.100766604  DT.91927115  DT.100845787  DT.100845800  DT.95156401  DT.120722946  DT.100845798  DT.102854 
    DT.100028677  DT.120722954  DT.120722989  DT.95227116  DT.97844930  DT.97844933  DT.97844934  DT.100845806 

    24/260 AceView cDNA sequences (see all 260):

    AL520638 AL046629 T16819 AF516603 BU182796 CR620801 L23767 BU153821 
    CR616349 BE047970 CR604023 BI050039 AA315495 BX359395 AA782382 CR614499 
    BC010645 CR624587 AF516604 BX093338 NM_006278 BQ639493 BM794729 BG831876 

    GeneLoc Exon Structure

    5/20 Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL4 (see all 20)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a · 14b ^ 15 ^
    SP1:                          -     -     -     -     -     -     -     -     -     -     -           -     -                 -     -           -               
    SP2:                                                                          -     -     -           -     -                       -           -               
    SP3:              -     -     -     -     -           -     -     -     -     -     -     -           -     -                       -           -               
    SP4:                                                                                                                                -                           
    SP5:              -     -     -     -     -     -     -     -     -     -     -     -     -           -     -                       -           -               

    ExUns: 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c ^ 21a · 21b ^ 22a · 22b · 22c ^ 23
    SP1:                                                  -                                 
    SP2:                                                  -                                 
    SP3:                                                                                    
    SP4:                                                  -                                 
    SP5:                                                                                    


    ECgene alternative splicing isoforms for ST3GAL4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ST3GAL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAAGAGCAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    ST3GAL4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Mature follicles (In-vitro growth and ...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ST3GAL4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ST3GAL4

    SOURCE GeneReport for Unigene cluster: Hs.591947

    UniProtKB/Swiss-Prot: SIA4C_HUMAN, Q11206
    Tissue specificity: Highly expressed in adult placenta, ovary and testes

        SABiosciences Custom PCR Arrays for ST3GAL4
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ST3GAL4 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ST3GAL41 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 76.32(n)
    77.44(a)
      419718  XM_417860.2  XP_417860.2 
    lizard
    (Anolis carolinensis)
    Reptilia ST3GAL46
    --
    71(a)
    1 ↔ 1
    GL343322.1(1289989-1303515)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.152722 Xenopus laevis transcribed sequence with weak similarity more 71.56(n)    CA791510.1 
    zebrafish
    (Danio rerio)
    Actinopterygii st3gal41 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 57.79(n)
    55.26(a)
      504044  NM_001003854.1  NP_001003854.1 


    ENSEMBL Gene Tree for ST3GAL4 (if available)
    TreeFam Gene Tree for ST3GAL4 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ST3GAL4 gene
    ST3GAL32  ST6GALNAC12  ST3GAL62  ST6GALNAC22  ST3GAL12  ST3GAL52  ST3GAL22  
    6 SIMAP similar genes for ST3GAL4 using alignment to 8 protein entries:     SIA4C_HUMAN (see all proteins):
    SIAT4C    ST3GAL1    ST3GAL6    ST3GAL3    ST3GalIII    ST3GAL5

    ST3GAL4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1078 NCBI SNPs in ST3GAL4 are shown (see all 1078    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1405838941,2
    --126223658(+) CAGTAA/CGAAAA 2 -- int1 us2k10--------
    rs1807583191,2
    --126223932(+) TCTTCC/GCTCTT 3 -- us2k1 int10--------
    rs1864045231,2
    --126223963(+) GGACTG/TAGTCA 3 -- us2k1 int10--------
    rs1909508761,2
    --126224225(+) GAACCC/TGGGAG 3 -- us2k1 int10--------
    rs1831434311,2
    --126224233(+) GAGGCA/GGAGGT 3 -- int1 us2k10--------
    rs1869689501,2
    --126224235(+) GGCAGA/CGGTTG 3 -- int1 us2k10--------
    rs1914080681,2
    --126224278(+) CCTGGC/TGACAG 3 -- int1 us2k10--------
    rs1162958801,2
    C,F,--126224380(+) GGCACC/TATATT 3 -- us2k1 int11Minor allele frequency- T:0.05WA 118
    rs1834225021,2
    --126224383(+) ACCATA/GTTCAA 3 -- us2k1 int10--------
    rs79371221,2
    C,F,A,H,--126224448(+) TTTAGG/CATGGA 3 -- us2k1 int118Minor allele frequency- C:0.37NS EA NA WA CSA 1209

    HapMap Linkage Disequilibrium report for ST3GAL4 (126225535 - 126310239 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ST3GAL4
         1 CNV: 66089

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    DNA2.0 Custom Variant and Variant Library Synthesis for ST3GAL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ST3GAL4 for disorders           About GeneDecksing

    OMIM gene information: 104240    OMIM disorders: --

    20/42 diseases for ST3GAL4 (see all 42):    About MalaCards
    cervical intraepithelial neoplasia    multiple endocrine neoplasia    glucose intolerance    mouth disease
    diabetes mellitus    insulin resistance    insulinoma    hyperlipidemia
    diabetic neuropathy    renal cell carcinoma    pterygium    cataract
    squamous cell carcinoma    hyperglycemia    nephropathy    colon carcinoma
    gigantism    colon cancer    dementia    neuropathy

    10/33 Novoseek disease relationships for ST3GAL4 gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperglycemia 77.9 41 10401233 (2), 11180699 (2), 11994404 (1), 15979893 (1) (see all 33)
    diabetes mellitus 58.3 10 17264983 (1), 9458968 (1), 10401233 (1), 11180699 (1) (see all 10)
    diabetes mellitus insulin-dependent 49.4 9 10614992 (1), 10666008 (1), 15590127 (1), 18373735 (1) (see all 8)
    diabetic nephropathies 47.4 4 14767489 (1), 12540629 (1), 14694265 (1), 18693296 (1)
    hyperlipidemia 45.1 2 10666008 (1), 18425420 (1)
    insulinoma 37.1 4 20176078 (3), 12234117 (1)
    niddm 30.7 5 9627363 (1), 9231649 (1), 9519717 (1)
    colon carcinoma 25.1 7 9343936 (2), 8364924 (1), 8044784 (1), 8611500 (1)
    hyperinsulinemia 22.4 2 14630571 (1), 12867535 (1)
    cognitive deficit 16.1 2 18515212 (1), 20398714 (1)

    Human Genome Epidemiology (HuGE) Navigator: ST3GAL4 (2 documents)

    Export disorders for ST3GAL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ST3GAL4 gene, integrated from 9 sources (see all 241):
    (articles sorted by number of sources associating them with ST3GAL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization and chromosomal mapping of the Gal beta 1,3GalNAc/Gal beta 1,4GlcNAc alpha 2,3-sialyltransferase. (PubMed id 8557707)1, 2, 3 Kitagawa H.... Paulson J.C. (1996)
    2. Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups. (PubMed id 8288606)1, 2, 3 Kitagawa H. and Paulson J.C. (1994)
    3. Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT- 3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP- NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line. (PubMed id 8611500)1, 2, 9 Basu S.S.... Basu S. (1996)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3- sialyltransferase using lectin resistance selection. (PubMed id 7901202)1, 2 Sasaki K.... Hasegawa M. (1993)
    7. Clinical significance of ST3Gal IV expression in human renal cell carcinoma. (PubMed id 12375029)1, 9 Saito S....Miyagi T. (2002)
    8. Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene. (PubMed id 17054948)1, 9 Higai K....Matsumoto K. (2006)
    9. Three genes that encode human beta-galactoside alpha 2,3- sialyltransferases. Structural analysis and chromosomal mapping studies. (PubMed id 7655169)1, 9 Chang M.-L.... Lau J.T.Y. (1995)
    10. Inhibition of H5N1 highly pathogenic influenza virus by suppressing a specific sialyltransferase. (PubMed id 20383541)1, 9 Monteerarat Y....Viprakasit V. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6484 HGNC: 10864 AceView: SIAT4C Ensembl:ENSG00000110080 euGenes: HUgn6484
    ECgene: ST3GAL4 Kegg: 6484 H-InvDB: ST3GAL4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ST3GAL4 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST3GAL4
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_625

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ST3GAL4 gene:
    Search GeneIP for patents involving ST3GAL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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