ST3GAL4 Gene
protein-coding GIFtS : 56
GCID: GC11 P126225
ST3 beta-galactoside alpha-2,3-sialyltransferase 4 (Previous name: sialyltransferase 4C (beta-galactosidase alpha-2,3-sialytransferase)... ) (Previous symbols: CGS23, SIAT4, NANTA3, SIAT4C )
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Aliasesfor ST3GAL4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4 1 2 ST3GalIV2 3 CGS231 2 3 5 FLJ118671 NANTA31 2 3 5 Alpha-3-N-Acetylneuraminyltransferase1 SIAT4C1 2 3 5 CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,3-Sialyltransferase 42 STZ1 2 3 Gal-NAc6S3 SIAT41 2 5 Gal-Beta-1,4-GalNAc-Alpha-2,3-Sialyltransferase1 SAT31 2 Sialyltransferase 4C (Beta-Galactoside Alpha-2,3-Sialytransferase)2 Sialyltransferase 4C (Beta-Galactosidase Alpha-2,3-Sialytransferase)1 2 EC 2.4.99.-3 Alpha 2,3-Sialyltransferase IV2 3 Gal-NAc6S3 Alpha 2,3-ST 42 3 Gal-Beta-1,4-GalNAc-Alpha-2,3-Sialyltransferase1 Beta-Galactoside Alpha-2,3-Sialyltransferase 42 3 Sialyltransferase 4C3 SAT-32 3 ST3Gal IV3 SIAT4-C2 3 EC 2.4.998 ST-42 3 EC 2.4.99.98 ST3GalA.22 3
Export aliases for ST3GAL4 gene to outside databases Previous GC identifers: GC11P125732 GC11P122170
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Summariesfor ST3GAL4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ST3GAL4 : This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2011) UniProtKB/Swiss-Prot: SIA4C_HUMAN, Q11206 Function : It may catalyze the formation of the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- orNeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc-sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant. Also acts on the corresponding 1,3-galactosyl derivative Gene Wiki entry for ST3GAL4
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Genomic Viewsfor ST3GAL4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_033899.8 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ST3GAL4 gene promoter: TBP Sp1 p53 AP-1 ATF-2 STAT5A NF-kappaB NF-kappaB1 Other transcription factors Search SABiosciences Chromatin IP Primers for ST3GAL4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ST3GAL4
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11q24.2 Ensembl cytogenetic band: 11q24.2 HGNC cytogenetic band: 11q23-q24 ST3GAL4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P126225: view genomic region
(about GC identifiers )
Start:
126,225,535 bp from pter
End:
126,310,239 bp from pter
Size:
84,705 bases
Orientation:
plus strand
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Proteinsfor ST3GAL4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SIA4C_HUMAN, Q11206 (See
protein sequence )Recommended Name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 Size : 333 amino acids; 38045 Da
Subcellular location : Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted.Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid
Secondary accessions : A8K6B2 O60497 Q96QQ9Alternative splicing : 5 isoforms : Q11206-1 Q11206-2 Q11206-3 Q11206-4 Q11206-5 Explore the universe of human proteins at neXtProt for ST3GAL4: NX_Q11206 Post-translational modifications:
The soluble form derives from the membrane form by proteolytic processing1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q11206 4 DME Specific Peptides for ST3GAL4 (Q11206 ) ST3GAL4 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (4 alternative transcripts):
NP_001241686.1 NP_001241687.1 NP_001241688.1 NP_006269.1 ENSEMBL proteins: ENSP00000433495 ENSP00000227495 ENSP00000432929 ENSP00000394354 ENSP00000433989 ENSP00000433318 ENSP00000432647 ENSP00000432424 ENSP00000434756 ENSP00000376437 ENSP00000436047 ENSP00000399444 ENSP00000434349 ENSP00000434668 ENSP00000431170 ENSP00000348451 Reactome Protein details: Q11206 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
ST3GAL4 for ontologies About GeneDecksing ST3GAL4 Antibody Products: Assay Products for ST3GAL4:
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Protein
Domains / Familiesfor ST3GAL4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ST3GAL4 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q11206 ProtoNet protein and cluster: Q11206
1 Blocks protein family : IPB001675 Glycosyl transferase UniProtKB/Swiss-Prot: SIA4C_HUMAN, Q11206 Similarity : Belongs to the glycosyltransferase 29 family
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Functionfor ST3GAL4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: SIA4C_HUMAN, Q11206 Function : It may catalyze the formation of the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- orNeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc-sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant. Also acts on the corresponding 1,3-galactosyl derivative Catalytic activity : CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP +alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein Enzyme Numbers (IUBMB): EC 2.4.99.9 2 EC 2.4.99.- 1 EC 2.4.99 2
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ST3GAL4 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ST3GAL4OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ST3GAL4 (NM_006278 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ST3GAL4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ST3GAL4
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST3GAL4
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
IEA -- GO:0005515 protein binding
-- -- GO:0008373 sialyltransferase activity
-- -- GO:0047288 monosialoganglioside sialyltransferase activity
IEA --
ST3GAL4 for ontologies About GeneDecksing Animal Models: Mouse knock-out St3gal4 tm1.1Jxm for ST3GAL4 5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for St3gal4) :
ST3GAL4 for phenotypes About GeneDecksing
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Pathways & Interactionsfor ST3GAL4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/11 super-pathways (see all 11 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 MPS IIIC - Sanfilippo syndrome C 2 N-glycan antennae elongation in the medial/trans-Golgi 3 Asparagine N-linked glycosylation 4 Keratan sulfate biosynthesis 5 Metabolism
Pathway sources See GeneCards unified pathways Show all pathways 5/30
Reactome Pathways for ST3GAL4 (see all 30 )2
Kegg Pathways (Kegg details for ST3GAL4) :UniProtKB/Swiss-Prot: SIA4C_HUMAN, Q11206 Pathway : Protein modification; protein glycosylation
ST3GAL4 for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ST3GAL4 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/34 Interacting proteins for ST3GAL4 (Q11206 3 ENSP00000227495 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 34 )
About this table Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005975 carbohydrate metabolic process
TAS -- GO:0006486 protein glycosylation
-- -- GO:0016266 O-glycan processing
TAS -- GO:0018146 keratan sulfate biosynthetic process
TAS -- GO:0018279 protein N-linked glycosylation via asparagine
TAS --
ST3GAL4 for ontologies About GeneDecksing
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Drugs & Compoundsfor ST3GAL4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
ST3GAL4 for compounds About GeneDecksing Browse Tocris compounds for ST3GAL4 10/13 HMDB Compounds for ST3GAL4 (see all 13 ) About this table Compound Synonyms
CAS
# PubMed Ids Cytidine monophosphate 5'-CMP (see all 14 ) 63-37-6 -- Cytidine monophosphate N-acetylneuraminic acid CMP-N-acetylneuraminate (see all 6 ) 22-12-8 -- Ganglioside GM1 (18:1/12:0) 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17 ) 104443-62-1 -- Ganglioside GM1 (18:1/16:0) 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17 ) 104443-62-1 -- Ganglioside GM1 (18:1/18:0) 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17 ) 104443-62-1 -- Ganglioside GM1 (18:1/20:0) 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17 ) 104443-62-1 -- Ganglioside GM1 (18:1/22:0) 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17 ) 104443-62-1 -- Ganglioside GM1 (18:1/9Z-18:1) 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17 ) 104443-62-1 -- Ganglioside GM1 (d18:1/24:0) 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17 ) 104443-62-1 -- Ganglioside GM1 (d18:1/24:1(15Z)) 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17 ) 104443-62-1 --
10/46 Novoseek chemical compound relationships for ST3GAL4 gene (see all 46 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
streptozotocin
95.1
938
14767489 (10), 17477963 (10), 7802703 (9), 8181671 (9) (see all 99 )
pugnac
72.4
12
11185566 (4), 15843043 (4)
alloxan
67.7
26
11841791 (5), 9218749 (3), 11467412 (3), 17045574 (3) (see all 9 )
glucose
66.2
74
17439741 (3), 9823013 (3), 7747600 (2), 15146370 (2) (see all 50 )
chloroethylnitrosourea
64.8
6
1427592 (3), 7554086 (1)
gal(beta1-3)galnac
59.5
3
7655169 (1), 10080950 (1)
bcnu
57.6
47
7802703 (7), 2137022 (4), 1533174 (4), 8364924 (3) (see all 9 )
o6-methylguanine
54.4
5
7554086 (1), 8364924 (1), 1825618 (1), 7802703 (1)
slex
54.2
3
17054948 (2), 15483269 (1)
nicotinamide
51.1
17
12006365 (3), 9519717 (3), 14630571 (2), 19728971 (1) (see all 8 )
Search CenterWatch for drugs/clinical trials and news about ST3GAL4 / SIA4C
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Transcriptsfor ST3GAL4 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ST3GAL4 gene (4 alternative transcripts): NM_001254757.1 NM_001254758.1 NM_001254759.1 NM_006278.2 Unigene Cluster for ST3GAL4:
ST3 beta-galactoside alpha-2,3-sialyltransferase 4 Hs.591947 [show with all ESTs ] Unigene Representative Sequence: AK128605 18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20 ): ENST00000534733 ENST00000227495 ENST00000531217 ENST00000444328 (uc001qds.3 )ENST00000530591 ENST00000534083 (uc001qdu.3 ) ENST00000528605 ENST00000526311 ENST00000528858 ENST00000534452 ENST00000392669 (uc021qry.1 uc001qdz.3 )ENST00000526756 ENST00000526727 (uc009zce.3 ) ENST00000449406 ENST00000532243 (uc001qdw.3 )ENST00000534457 ENST00000524834 (uc001qdx.1 ) ENST00000524860 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ST3GAL4 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ST3GAL4OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ST3GAL4 (NM_006278 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ST3GAL4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ST3GAL4
Additional cDNA sequence: AB009393.1 AF035249.1 AF516602.1 AF516603.1 AF516604.1 AF525084.1 AK128605.1 AK291577.1 AK314738.1 AY040826.1 BC010645.1 CR456858.1 L23767.1 X74570.1
24 DOTS entries : DT.443842 DT.100845793
DT.95112531 DT.120722835 DT.100845789 DT.95156400 DT.91754260 DT.95156404 DT.100766604 DT.91927115 DT.100845787 DT.100845800 DT.95156401 DT.120722946 DT.100845798 DT.102854 DT.100028677 DT.120722954 DT.120722989 DT.95227116 DT.97844930 DT.97844933 DT.97844934 DT.100845806 24/260 AceView cDNA sequences (see all 260 ):
AL520638 AL046629 T16819 AF516603 BU182796 CR620801 L23767 BU153821 CR616349 BE047970 CR604023 BI050039 AA315495 BX359395 AA782382 CR614499 BC010645 CR624587 AF516604 BX093338 NM_006278 BQ639493 BM794729 BG831876 GeneLoc Exon Structure 5/20 Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL4 (see all 20 ) About this scheme ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a · 14b ^ 15 ^ SP1 :         -   -   -   -   -   -   -   -   -   -   -     -   -       -   -     -       SP2 :                         -   -   -     -   -         -     -       SP3 :     -   -   -   -   -     -   -   -   -   -   -   -     -   -         -     -       SP4 :                                           -           SP5 :     -   -   -   -   -   -   -   -   -   -   -   -   -     -   -         -     -      
ExUns: 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c ^ 21a · 21b ^ 22a · 22b · 22c ^ 23 SP1 :                 -             SP2 :                 -             SP3 :                             SP4 :                 -             SP5 :                            
ECgene alternative splicing isoforms for ST3GAL4
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Expression for ST3GAL4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ST3GAL4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGAAGAGCAC
About this image ST3GAL4 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Mature follicles (In-vitro growth and ... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See ST3GAL4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ST3GAL4 SOURCE GeneReport for Unigene cluster: Hs.591947 UniProtKB/Swiss-Prot: SIA4C_HUMAN, Q11206 Tissue specificity : Highly expressed in adult placenta, ovary and testes SABiosciences Custom PCR Arrays for ST3GAL4 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ST3GAL4Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ST3GAL4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ST3GAL4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ST3GAL4 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST3GAL4
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Orthologsfor ST3GAL4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for ST3GAL4 gene from 4/12 species (see all 12 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
ST3GAL41
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
76.32(n) 77.44(a)
 
419718 XM_417860.2 XP_417860.2
lizard (Anolis carolinensis)
Reptilia
ST3GAL46
--
71(a)
1 ↔ 1
GL343322.1(1289989-1303515)
African clawed frog (Xenopus laevis)
Amphibia
Xl.152722
Xenopus laevis transcribed sequence with weak similarity more
71.56(n)
 
CA791510.1
zebrafish (Danio rerio)
Actinopterygii
st3gal41
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
57.79(n) 55.26(a)
 
504044 NM_001003854.1 NP_001003854.1
ENSEMBL Gene Tree for ST3GAL4 (if available)TreeFam Gene Tree for ST3GAL4 (if available)
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Paralogsfor ST3GAL4 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ST3GAL4 gene ST3GAL3 2 ST6GALNAC1 2 ST3GAL6 2 ST6GALNAC2 2 ST3GAL1 2 ST3GAL5 2 ST3GAL2 2 6 SIMAP similar genes for ST3GAL4 using alignment to 8 protein entries: SIA4C_HUMAN (see all proteins ):SIAT4C ST3GAL1 ST3GAL6 ST3GAL3 ST3GalIII ST3GAL5
ST3GAL4 for paralogs About GeneDecksing
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Genomic Variantsfor ST3GAL4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ST3GAL4 (126225535 - 126310239 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for ST3GAL4 1 CNV : 66089
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ST3GAL4
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Disorders
/ Diseasesfor ST3GAL4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ST3GAL4 for disorders About GeneDecksing
OMIM gene information: 104240
OMIM disorders : --20/42 diseases for ST3GAL4 (see all 42 ): About MalaCards cervical intraepithelial neoplasia multiple endocrine neoplasia glucose intolerance mouth disease diabetes mellitus insulin resistance insulinoma hyperlipidemia diabetic neuropathy renal cell carcinoma pterygium cataract squamous cell carcinoma hyperglycemia nephropathy colon carcinoma gigantism colon cancer dementia neuropathy 10/33 Novoseek disease relationships for ST3GAL4 gene (see all 33 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
hyperglycemia
77.9
41
10401233 (2), 11180699 (2), 11994404 (1), 15979893 (1) (see all 33 )
diabetes mellitus
58.3
10
17264983 (1), 9458968 (1), 10401233 (1), 11180699 (1) (see all 10 )
diabetes mellitus insulin-dependent
49.4
9
10614992 (1), 10666008 (1), 15590127 (1), 18373735 (1) (see all 8 )
diabetic nephropathies
47.4
4
14767489 (1), 12540629 (1), 14694265 (1), 18693296 (1)
hyperlipidemia
45.1
2
10666008 (1), 18425420 (1)
insulinoma
37.1
4
20176078 (3), 12234117 (1)
niddm
30.7
5
9627363 (1), 9231649 (1), 9519717 (1)
colon carcinoma
25.1
7
9343936 (2), 8364924 (1), 8044784 (1), 8611500 (1)
hyperinsulinemia
22.4
2
14630571 (1), 12867535 (1)
cognitive deficit
16.1
2
18515212 (1), 20398714 (1)
Human Genome Epidemiology (HuGE) Navigator: ST3GAL4 (2 documents) Export disorders for ST3GAL4 gene to outside databases
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Publicationsfor ST3GAL4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ST3GAL4 gene, integrated from 9 sources (see all 241 ): (articles sorted by number of sources associating them with ST3GAL4) Utopia : connect your pdf to the dynamic world of online information
Genomic organization and chromosomal mapping of the Gal beta 1,3GalNAc/Gal beta 1,4GlcNAc alpha 2,3-sialyltransferase. (PubMed id 8557707) 1 , 2 , 3 Kitagawa H.... Paulson J.C. (1996) Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups. (PubMed id 8288606) 1 , 2 , 3 Kitagawa H. and Paulson J.C. (1994) Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT- 3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP- NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line. (PubMed id 8611500) 1 , 2 , 9 Basu S.S.... Basu S. (1996) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3- sialyltransferase using lectin resistance selection. (PubMed id 7901202) 1 , 2 Sasaki K.... Hasegawa M. (1993) Clinical significance of ST3Gal IV expression in human renal cell carcinoma. (PubMed id 12375029) 1 , 9 Saito S....Miyagi T. (2002) Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene. (PubMed id 17054948) 1 , 9 Higai K....Matsumoto K. (2006) Three genes that encode human beta-galactoside alpha 2,3- sialyltransferases. Structural analysis and chromosomal mapping studies. (PubMed id 7655169) 1 , 9 Chang M.-L.... Lau J.T.Y. (1995) Inhibition of H5N1 highly pathogenic influenza virus by suppressing a specific sialyltransferase. (PubMed id 20383541) 1 , 9 Monteerarat Y....Viprakasit V. (2010)
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External Searches for ST3GAL4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ST3GAL4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ST3GAL4 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ST3GAL4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ST3GAL4 Pharmacogenomics, SNPs, Pathways GGDB http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST3GAL4 Functional Glycomics Gateway - GTase http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_625
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About This Section Patent Information for ST3GAL4 gene: Search GeneIP for patents involving ST3GAL4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ST3GAL4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ST3GAL4 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ST3GAL4 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ST3GAL4 OriGene Protein Over-expression Lysate for ST3GAL4 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ST3GAL4 OriGene 3'-UTR Clone for ST3GAL4 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ST3GAL4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ST3GAL4 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ST3GAL4 OriGene Custom Protein Services for ST3GAL4 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ST3GAL4 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ST3GAL4 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ST3GAL4 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ST3GAL4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ST3GAL4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ST3GAL4
Search Tocris compounds for ST3GAL4
ST3GAL4 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST3GAL4
Search ThermoFisher Antibodies for ST3GAL4
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ST3GAL4
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