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ST3GAL4 Gene

protein-coding   GIFtS: 57
GCID: GC11P126225

ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4

(Previous name: sialyltransferase 4C (beta-galactosidase alpha-2,3-sialytransferase))
(Previous symbols: CGS23, SIAT4, NANTA3, SIAT4C)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 41 2     ST3GalIV2 3
CGS231 2 3 5     STZ2 3
NANTA31 2 3 5     SAT32
SIAT4C1 2 3 5     alpha-3-N-acetylneuraminyltransferase2
SIAT41 2 5     CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,3-Sialyltransferase 42
Sialyltransferase 4C (Beta-Galactosidase Alpha-2,3-Sialytransferase)1 2     gal-NAc6S2
ST3Gal IV1 3     gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase2
Alpha 2,3-Sialyltransferase IV2 3     Sialyltransferase 4C (Beta-Galactoside Alpha-2,3-Sialytransferase)2
Alpha 2,3-ST 42 3     EC 2.4.99.-3
Beta-Galactoside Alpha-2,3-Sialyltransferase 42 3     Gal-NAc6S3
SAT-32 3     Gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase3
SIAT4-C2 3     Sialyltransferase 4C3
ST-42 3     EC 2.4.998
ST3GalA.22 3     EC 2.4.99.98

External Ids:    HGNC: 108641   Entrez Gene: 64842   Ensembl: ENSG000001100807   OMIM: 1042405   UniProtKB: Q112063   

Export aliases for ST3GAL4 gene to outside databases

Previous GC identifers: GC11P125732 GC11P122170


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ST3GAL4 Gene:
This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein
glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and
secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in
inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Dec 2011)

GeneCards Summary for ST3GAL4 Gene:
ST3GAL4 (ST3 beta-galactoside alpha-2,3-sialyltransferase 4) is a protein-coding gene. GO annotations related to this gene include beta-galactoside (CMP) alpha-2,3-sialyltransferase activity and monosialoganglioside sialyltransferase activity. An important paralog of this gene is ST3GAL3.

UniProtKB/Swiss-Prot: SIA4C_HUMAN, Q11206
Function: It may catalyze the formation of the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- or
NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc-sequences found in terminal carbohydrate groups of glycoproteins and
glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant. Also acts on the
corresponding 1,3-galactosyl derivative

Gene Wiki entry for ST3GAL4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ST3GAL4 gene promoter:
         TBP   Sp1   p53   AP-1   ATF-2   STAT5A   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ST3GAL4 promoter sequence
   Search Chromatin IP Primers for ST3GAL4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST3GAL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q23-q24

ST3GAL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST3GAL4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P126225:  view genomic region     (about GC identifiers)

Start:
126,225,535 bp from pter      End:
126,310,239 bp from pter
Size:
84,705 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIA4C_HUMAN, Q11206 (See protein sequence)
Recommended Name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4  
Size: 333 amino acids; 38045 Da
Secondary accessions: A8K6B2 O60497 Q8N6A6 Q8NFG7 Q96QQ9
Alternative splicing: 7 isoforms:  Q11206-1   Q11206-2   Q11206-3   Q11206-4   Q11206-5   Q11206-6   Q11206-7   

Explore the universe of human proteins at neXtProt for ST3GAL4: NX_Q11206

Explore proteomics data for ST3GAL4 at MOPED

Post-translational modifications: 

  • The soluble form derives from the membrane form by proteolytic processing1
  • Glycosylation2 at Asn61, Asn131, Asn310, Asn329
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for ST3GAL4 (Q11206)
     RLFYPES  DVVIRLN  CVVVGNG  NKKQTIHYYEQITLKSMAGSGHNVSQEA 


    See ST3GAL4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001241686.1  NP_001241687.1  NP_001241688.1  NP_006269.1  

    ENSEMBL proteins: 
     ENSP00000433495   ENSP00000227495   ENSP00000432929   ENSP00000394354   ENSP00000433989  
     ENSP00000433318   ENSP00000432647   ENSP00000432424   ENSP00000434756   ENSP00000376437  
     ENSP00000436047   ENSP00000399444   ENSP00000434349   ENSP00000434668   ENSP00000431170  
     ENSP00000348451  
    Reactome Protein details: Q11206

    ST3GAL4 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ST3GAL4
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    Novus Biologicals ST3GAL4 Protein
    Novus Biologicals ST3GAL4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ST3GAL4 

    ST3GAL4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for ST3GAL4

    ST3GAL4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ST3GAL4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ST3G: Sialyltransferases

    2 InterPro protein domains:
     IPR001675 Glyco_trans_29
     IPR012163 Sialyl_trans

    Graphical View of Domain Structure for InterPro Entry Q11206

    ProtoNet protein and cluster: Q11206

    1 Blocks protein domain: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIA4C_HUMAN, Q11206
    Similarity: Belongs to the glycosyltransferase 29 family


    Find genes that share domains with ST3GAL4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIA4C_HUMAN, Q11206
    Function: It may catalyze the formation of the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- or
    NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc-sequences found in terminal carbohydrate groups of glycoproteins and
    glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant. Also acts on the
    corresponding 1,3-galactosyl derivative
    Catalytic activity: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP +
    alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein

         Enzyme Numbers (IUBMB): EC 2.4.99.92 EC 2.4.99.-1 EC 2.4.992

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003836beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IEA--
    GO:0005515protein binding ----
    GO:0008373sialyltransferase activity ----
    GO:0047288monosialoganglioside sialyltransferase activity IEA--
         
    Find genes that share ontologies with ST3GAL4           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for St3gal4):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  no phenotypic analysis 

    Find genes that share phenotypes with ST3GAL4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out St3gal4tm1.1Jxm for ST3GAL4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ST3GAL4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ST3GAL4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ST3GAL4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ST3GAL4

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ST3GAL4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ST3GAL4 (see all 10):
    hsa-miR-3163 hsa-miR-3651 hsa-miR-216b hsa-miR-548t hsa-miR-1468 hsa-miR-3121-3p hsa-miR-3649 hsa-miR-651
    SwitchGear 3'UTR luciferase reporter plasmidST3GAL4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ST3GAL4
    Predesigned siRNA for gene silencing in human, mouse, rat ST3GAL4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ST3GAL4

    Clone
    Products:
         
    OriGene clones in human, mouse for ST3GAL4 (see all 7)
    OriGene ORF clones in mouse, rat for ST3GAL4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ST3GAL4 (NM_006278)
    Sino Biological Human cDNA Clone for ST3GAL4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST3GAL4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST3GAL4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ST3GAL4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST3GAL4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIA4C_HUMAN, Q11206: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted.
    Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus5
    endoplasmic reticulum1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005576extracellular region IEA--
    GO:0005794Golgi apparatus ----
    GO:0016021integral component of membrane ----
    GO:0030173integral component of Golgi membrane IEA--

    Find genes that share ontologies with ST3GAL4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ST3GAL4 About   (see all 10)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    2MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Metabolism of proteins0.30
    Post-translational protein modification0.43
    N-glycan antennae elongation in the medial/trans-Golgi0.00
    Transport to the Golgi and subsequent modification0.40
    N-Glycan antennae elongation0.00
    4Keratan sulfate/keratin metabolism
    Keratan sulfate/keratin metabolism0.85
    Keratan sulfate biosynthesis0.85
    5Pre-NOTCH Expression and Processing
    Pre-NOTCH Expression and Processing0.62
    Pre-NOTCH Processing in Golgi0.00


    Find genes that share SuperPaths with ST3GAL4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5 Reactome Pathways for ST3GAL4
        Pre-NOTCH Processing in Golgi
    Sialic acid metabolism
    N-Glycan antennae elongation
    Keratan sulfate biosynthesis
    Termination of O-glycan biosynthesis


    2 Kegg Pathways  (Kegg details for ST3GAL4):
        Glycosphingolipid biosynthesis - lacto and neolacto series
    Metabolic pathways

    UniProtKB/Swiss-Prot: SIA4C_HUMAN, Q11206
    Pathway: Protein modification; protein glycosylation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ST3GAL4
    Interactions:

        Search GeneGlobe Interaction Network for ST3GAL4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ST3GAL4 (Q112063 ENSP000002274954) via UniProtKB, MINT, STRING, and/or I2D (see all 34)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD8BP109663, ENSP000003311724I2D: score=1 STRING: ENSP00000331172
    ARHGDIAP525653, ENSP000002693214I2D: score=2 STRING: ENSP00000269321
    B3GALT1ENSP000003037404STRING: ENSP00000303740
    B3GALT5ENSP000003433184STRING: ENSP00000343318
    CHST2ENSP000003079114STRING: ENSP00000307911
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006486protein glycosylation ----
    GO:0016266O-glycan processing TAS--
    GO:0018146keratan sulfate biosynthetic process TAS--
    GO:0018279protein N-linked glycosylation via asparagine TAS--

    Find genes that share ontologies with ST3GAL4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ST3GAL4 (SIA4C)

    Selected HMDB Compounds for ST3GAL4 (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cytidine monophosphate5'-CMP (see all 14)63-37-6--
    Cytidine monophosphate N-acetylneuraminic acidCMP-N-acetylneuraminate (see all 6)22-12-8--
    Ganglioside GM1 (18:1/12:0)1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17)104443-62-1--
    Ganglioside GM1 (18:1/16:0)1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17)104443-62-1--
    Ganglioside GM1 (18:1/18:0)1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17)104443-62-1--
    Ganglioside GM1 (18:1/20:0)1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17)104443-62-1--
    Ganglioside GM1 (18:1/22:0)1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17)104443-62-1--
    Ganglioside GM1 (18:1/9Z-18:1)1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17)104443-62-1--
    Ganglioside GM1 (d18:1/24:0)1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17)104443-62-1--
    Ganglioside GM1 (d18:1/24:1(15Z))1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17)104443-62-1--

    Selected Novoseek inferred chemical compound relationships for ST3GAL4 gene (see all 46)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    streptozotocin 95.1 938 14767489 (10), 17477963 (10), 7802703 (9), 8181671 (9) (see all 99)
    pugnac 72.4 12 11185566 (4), 15843043 (4)
    alloxan 67.7 26 11841791 (5), 9218749 (3), 11467412 (3), 17045574 (3) (see all 9)
    glucose 66.2 74 17439741 (3), 9823013 (3), 7747600 (2), 15146370 (2) (see all 50)
    chloroethylnitrosourea 64.8 6 1427592 (3), 7554086 (1)
    gal(beta1-3)galnac 59.5 3 7655169 (1), 10080950 (1)
    bcnu 57.6 47 7802703 (7), 2137022 (4), 1533174 (4), 8364924 (3) (see all 9)
    o6-methylguanine 54.4 5 7554086 (1), 8364924 (1), 1825618 (1), 7802703 (1)
    slex 54.2 3 17054948 (2), 15483269 (1)
    nicotinamide 51.1 17 12006365 (3), 9519717 (3), 14630571 (2), 19728971 (1) (see all 8)



    Find genes that share compounds with ST3GAL4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ST3GAL4 gene (4 alternative transcripts): 
    NM_001254757.1  NM_001254758.1  NM_001254759.1  NM_006278.2  

    Unigene Cluster for ST3GAL4:

    ST3 beta-galactoside alpha-2,3-sialyltransferase 4
    Hs.591947  [show with all ESTs]
    Unigene Representative Sequence: AK128605
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000534733 ENST00000227495 ENST00000531217 ENST00000444328(uc001qds.3)
    ENST00000530591 ENST00000534083(uc001qdu.3) ENST00000528605 ENST00000526311
    ENST00000528858 ENST00000534452 ENST00000392669(uc021qry.1 uc001qdz.3)
    ENST00000526756 ENST00000526727(uc009zce.3) ENST00000449406 ENST00000532243(uc001qdw.3)
    ENST00000534457 ENST00000524834(uc001qdx.1) ENST00000524860
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ST3GAL4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ST3GAL4 (see all 10):
    hsa-miR-3163 hsa-miR-3651 hsa-miR-216b hsa-miR-548t hsa-miR-1468 hsa-miR-3121-3p hsa-miR-3649 hsa-miR-651
    SwitchGear 3'UTR luciferase reporter plasmidST3GAL4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ST3GAL4
    Predesigned siRNA for gene silencing in human, mouse, rat ST3GAL4
    Clone
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    OriGene clones in human, mouse for ST3GAL4 (see all 7)
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      QuantiFast Probe-based Assays in human, mouse, rat ST3GAL4

    Additional mRNA sequence: 

    AB009393.1 AF035249.1 AF516602.1 AF516603.1 AF516604.1 AF525084.1 AK128605.1 AK291577.1 
    AK314738.1 AY040826.1 BC010645.1 CR456858.1 L23767.1 X74570.1 

    24 DOTS entries:

    DT.443842  DT.100845793  DT.95112531  DT.120722835  DT.100845789  DT.95156400  DT.91754260  DT.95156404 
    DT.100766604  DT.91927115  DT.100845787  DT.100845800  DT.95156401  DT.120722946  DT.100845798  DT.102854 
    DT.100028677  DT.120722954  DT.120722989  DT.95227116  DT.97844930  DT.97844933  DT.97844934  DT.100845806 

    Selected AceView cDNA sequences (see all 260):

    BM794729 CR595607 BU182796 CA415861 CR610249 CR616349 BE047970 CR602167 
    BI259855 AA315495 BU178366 NM_006278 AA470419 AF516602 BQ639493 AA782382 
    BE018022 AL520638 BX359395 CR614499 T16819 CR598875 BG831876 CR616626 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL4 (see all 20)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a · 14b ^ 15 ^
    SP1:                          -     -     -     -     -     -     -     -     -     -     -           -     -                 -     -           -               
    SP2:                                                                          -     -     -           -     -                       -           -               
    SP3:              -     -     -     -     -           -     -     -     -     -     -     -           -     -                       -           -               
    SP4:                                                                                                                                -                           
    SP5:              -     -     -     -     -     -     -     -     -     -     -     -     -           -     -                       -           -               

    ExUns: 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c ^ 21a · 21b ^ 22a · 22b · 22c ^ 23
    SP1:                                                  -                                 
    SP2:                                                  -                                 
    SP3:                                                                                    
    SP4:                                                  -                                 
    SP5:                                                                                    


    ECgene alternative splicing isoforms for ST3GAL4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ST3GAL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAGAGCAC
    ST3GAL4 Expression
    About this image


    ST3GAL4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Ovary (Reproductive System)
             Mature follicles
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Colon (Gastrointestinal Tract)
    ST3GAL4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ST3GAL4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591947

    UniProtKB/Swiss-Prot: SIA4C_HUMAN, Q11206
    Tissue specificity: Highly expressed in adult placenta, ovary and testes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ST3GAL4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St3gal41 , 5 ST3 beta-galactoside alpha-2,3-sialyltransferase 41, 5 85.89(n)1
    89.49(a)1
      9 (19.36 cM)5
    204431  NM_009178.31  NP_033204.21 
     350465795 
    chicken
    (Gallus gallus)
    Aves ST3GAL41 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 76.02(n)
    76.52(a)
      419718  XM_417860.3  XP_417860.3 
    lizard
    (Anolis carolinensis)
    Reptilia ST3GAL46
    ST3 beta-galactoside alpha-2,3-sialyltransferase 4...
    67(a)
    1 ↔ 1
    GL343322.1(1279903-1306672)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.152722 Xenopus laevis transcribed sequence with weak similarity more 71.56(n)    CA791510.1 
    zebrafish
    (Danio rerio)
    Actinopterygii st3gal41 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 58.42(n)
    56.36(a)
      504044  NM_001003854.1  NP_001003854.1 


    ENSEMBL Gene Tree for ST3GAL4 (if available)
    TreeFam Gene Tree for ST3GAL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ST3GAL4 gene
    ST3GAL32  ST6GALNAC12  ST3GAL62  ST6GALNAC22  ST3GAL12  ST3GAL22  ST3GAL52  
    6 SIMAP similar genes for ST3GAL4 using alignment to 7 protein entries:     SIA4C_HUMAN (see all proteins):
    SIAT4C    ST3GAL1    ST3GAL6    ST3GAL3    ST3GalIII    ST3GAL5

    Find genes that share paralogs with ST3GAL4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ST3GAL4 (see all 1198)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1424048451,2
    --126227553(+) TTAATA/CCTGGA 2 -- int10--------
    rs714759541,2
    C,F--126227641(+) AACTCC/TCCACT 2 -- int12Minor allele frequency- T:0.50NA 4
    rs799375221,2
    C,F--126227698(+) GGCACG/ATTCTC 2 -- int12Minor allele frequency- A:0.06CSA WA 120
    rs1871457841,2
    --126227722(+) AGAGAA/GGCTGC 2 -- int10--------
    rs79285771,2
    C,F--126227723(+) GAGAGG/TCTGCT 2 -- int17Minor allele frequency- T:0.18NA WA CSA EA 365
    rs1920662451,2
    --126227814(+) CCTCTA/GTCTTG 2 -- int10--------
    rs1833319441,2
    --126227828(+) TAATAC/TAAATG 2 -- int10--------
    rs1141707661,2
    F--126227839(+) TTTCCG/CTGCCT 2 -- int11Minor allele frequency- C:0.05WA 118
    rs1402388351,2
    C--126227898(+) CCTGCA/GGGGGA 2 -- int10--------
    rs1469533631,2
    --126227997(+) TGGCCA/CCTCGG 2 -- int10--------

    HapMap Linkage Disequilibrium report for ST3GAL4 (126225535 - 126310239 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ST3GAL4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745215CNV Deletion23290073
    esv2672750CNV Deletion23128226
    nsv898442CNV Gain21882294
    nsv527257CNV Gain19592680
    nsv826123CNV Gain20364138
    esv24669CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ST3GAL4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 104240    OMIM disorders: --


    Find genes that share disorders with ST3GAL4           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ST3GAL4 gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperglycemia 77.9 41 10401233 (2), 11180699 (2), 11994404 (1), 15979893 (1) (see all 33)
    diabetes mellitus 58.3 10 17264983 (1), 9458968 (1), 10401233 (1), 11180699 (1) (see all 10)
    diabetes mellitus insulin-dependent 49.4 9 10614992 (1), 10666008 (1), 15590127 (1), 18373735 (1) (see all 8)
    diabetic nephropathies 47.4 4 14767489 (1), 12540629 (1), 14694265 (1), 18693296 (1)
    hyperlipidemia 45.1 2 10666008 (1), 18425420 (1)
    insulinoma 37.1 4 20176078 (3), 12234117 (1)
    niddm 30.7 5 9627363 (1), 9231649 (1), 9519717 (1)
    colon carcinoma 25.1 7 9343936 (2), 8364924 (1), 8044784 (1), 8611500 (1)
    hyperinsulinemia 22.4 2 14630571 (1), 12867535 (1)
    cognitive deficit 16.1 2 18515212 (1), 20398714 (1)

    Genetic Association Database (GAD): ST3GAL4
    Human Genome Epidemiology (HuGE) Navigator: ST3GAL4 (2 documents)

    Export disorders for ST3GAL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ST3GAL4 gene, integrated from 10 sources (see all 245):
    (articles sorted by number of sources associating them with ST3GAL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization and chromosomal mapping of the Gal beta 1,3GalNAc/Gal beta 1,4GlcNAc alpha 2,3-sialyltransferase. (PubMed id 8557707)1, 2, 3 Kitagawa H.... Paulson J.C. (J. Biol. Chem. 1996)
    2. Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups. (PubMed id 8288606)1, 2, 3 Kitagawa H. and Paulson J.C. (J. Biol. Chem. 1994)
    3. Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT- 3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP- NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line. (PubMed id 8611500)1, 2, 9 Basu S.S.... Basu S. (Biochemistry 1996)
    4. Identification of nine alternatively spliced alpha2,3- sialyltransferase, ST3Gal IV, transcripts and analysis of their expression by RT-PCR and laser-induced fluorescent capillary electrophoresis (LIF-CE) in twenty-one human tissues. (PubMed id 12441665)1, 2, 9 Grahn A. and Larson G. (Glycoconj. J. 2001)
    5. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PubMed id 21378990)1, 4 Schunkert H....Samani N.J. (Nat. Genet. 2011)
    6. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PubMed id 22001757)1, 4 Chambers J.C....Kooner J.S. (Nat. Genet. 2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Biological, clinical and population relevance of 95 loci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (Nature 2010)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6484 HGNC: 10864 AceView: SIAT4C Ensembl:ENSG00000110080 euGenes: HUgn6484
    ECgene: ST3GAL4 Kegg: 6484 H-InvDB: ST3GAL4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ST3GAL4 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST3GAL4
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_625

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ST3GAL4 gene:
    Search GeneIP for patents involving ST3GAL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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