Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ST3GAL4 Gene

Aliases for ST3GAL4 Gene

  • ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4 2 3
  • NANTA3 3 4 6
  • SIAT4C 3 4 6
  • CGS23 3 4 6
  • Sialyltransferase 4C (Beta-Galactosidase Alpha-2,3-Sialytransferase) 2 3
  • Gal-Beta-1,4-GalNAc-Alpha-2,3-Sialyltransferase 3 4
  • Beta-Galactoside Alpha-2,3-Sialyltransferase 4 3 4
  • Alpha 2,3-Sialyltransferase IV 3 4
  • Alpha 2,3-ST 4 3 4
  • Gal-NAc6S 3 4
  • ST3GalA.2 3 4
  • ST3Gal IV 2 4
  • ST3GalIV 3 4
  • SIAT4-C 3 4
  • SIAT4 3 6
  • SAT-3 3 4
  • ST-4 3 4
  • STZ 3 4
  • CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,3-Sialyltransferase 4 3
  • Sialyltransferase 4C (Beta-Galactoside Alpha-2,3-Sialytransferase) 3
  • Alpha-3-N-Acetylneuraminyltransferase 3
  • Sialyltransferase 4C 4
  • EC 2.4.99.9 64
  • EC 2.4.99.- 4
  • EC 2.4.99 64
  • SAT3 3

External Ids for ST3GAL4 Gene

Previous Symbols for ST3GAL4 Gene

  • CGS23
  • SIAT4
  • NANTA3
  • SIAT4C

Summaries for ST3GAL4 Gene

Entrez Gene Summary for ST3GAL4 Gene

  • This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for ST3GAL4 Gene

ST3GAL4 (ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include beta-galactoside (CMP) alpha-2,3-sialyltransferase activity and monosialoganglioside sialyltransferase activity. An important paralog of this gene is ST6GALNAC2.

UniProtKB/Swiss-Prot for ST3GAL4 Gene

  • It may catalyze the formation of the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- or NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc-sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant. Also acts on the corresponding 1,3-galactosyl derivative.

Gene Wiki entry for ST3GAL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST3GAL4 Gene

Genomics for ST3GAL4 Gene

Genomic Location for ST3GAL4 Gene

Start:
126,355,640 bp from pter
End:
126,440,344 bp from pter
Size:
84,705 bases
Orientation:
Plus strand

Genomic View for ST3GAL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ST3GAL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST3GAL4 Gene

Regulatory Elements for ST3GAL4 Gene

Proteins for ST3GAL4 Gene

  • Protein details for ST3GAL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q11206-SIA4C_HUMAN
    Recommended name:
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
    Protein Accession:
    Q11206
    Secondary Accessions:
    • A8K6B2
    • O60497
    • Q8N6A6
    • Q8NFG7
    • Q96QQ9

    Protein attributes for ST3GAL4 Gene

    Size:
    333 amino acids
    Molecular mass:
    38045 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ST3GAL4 Gene

neXtProt entry for ST3GAL4 Gene

Proteomics data for ST3GAL4 Gene at MOPED

Selected DME Specific Peptides for ST3GAL4 Gene

Post-translational modifications for ST3GAL4 Gene

  • The soluble form derives from the membrane form by proteolytic processing
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn61, Asn131, Asn310, and Asn329

Domains for ST3GAL4 Gene

Gene Families for ST3GAL4 Gene

HGNC:
  • ST3G :Sialyltransferases

Protein Domains for ST3GAL4 Gene

UniProtKB/Swiss-Prot:

SIA4C_HUMAN
Family:
  • Belongs to the glycosyltransferase 29 family.:
    • Q11206
genes like me logo Genes that share domains with ST3GAL4: view

Function for ST3GAL4 Gene

Molecular function for ST3GAL4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein
UniProtKB/Swiss-Prot Function: It may catalyze the formation of the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- or NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc-sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant. Also acts on the corresponding 1,3-galactosyl derivative.

Enzyme Numbers (IUBMB) for ST3GAL4 Gene

Gene Ontology (GO) - Molecular Function for ST3GAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IEA --
GO:0005515 protein binding --
GO:0008373 sialyltransferase activity --
GO:0047288 monosialoganglioside sialyltransferase activity IEA --
genes like me logo Genes that share ontologies with ST3GAL4: view
genes like me logo Genes that share phenotypes with ST3GAL4: view

Animal Models for ST3GAL4 Gene

MGI Knock Outs for ST3GAL4:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for ST3GAL4 Gene

Localization for ST3GAL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST3GAL4 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST3GAL4 Gene COMPARTMENTS Subcellular localization image for ST3GAL4 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ST3GAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane --
GO:0030173 integral component of Golgi membrane IEA --
genes like me logo Genes that share ontologies with ST3GAL4: view

Pathways for ST3GAL4 Gene

genes like me logo Genes that share pathways with ST3GAL4: view

UniProtKB/Swiss-Prot Q11206-SIA4C_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for ST3GAL4 Gene

Gene Ontology (GO) - Biological Process for ST3GAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006486 protein glycosylation --
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
genes like me logo Genes that share ontologies with ST3GAL4: view

Compounds for ST3GAL4 Gene

(13) HMDB Compounds for ST3GAL4 Gene

Compound Synonyms Cas Number PubMed IDs
Cytidine monophosphate
  • 5'-CMP
63-37-6
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-acetylneuraminate
22-12-8
Ganglioside GM1 (18:1/12:0)
  • 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide
104443-62-1
Ganglioside GM1 (18:1/16:0)
  • 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide
104443-62-1
Ganglioside GM1 (18:1/18:0)
  • 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide
104443-62-1

(46) Novoseek inferred chemical compound relationships for ST3GAL4 Gene

Compound -log(P) Hits PubMed IDs
streptozotocin 95.1 402
pugnac 72.4 8
alloxan 67.7 20
glucose 66.2 58
chloroethylnitrosourea 64.8 4
genes like me logo Genes that share compounds with ST3GAL4: view

Transcripts for ST3GAL4 Gene

Unigene Clusters for ST3GAL4 Gene

ST3 beta-galactoside alpha-2,3-sialyltransferase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a · 14b ^ 15 ^
SP1: - - - - - - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - - - - -
SP4: -
SP5: - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - -
SP10: - - - - - - - - - - - - - - - - -
SP11: - -
SP12: -
SP13: - - - - - - - - - - - -
SP14: - - - - -
SP15: - - - - - - - - - - - - - - -
SP16: - - - - - - - -
SP17:
SP18: - - - - - - - - - - - -
SP19: - - - - - - - - - - - - - -
SP20:

ExUns: 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c ^ 21a · 21b ^ 22a · 22b · 22c ^ 23
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11: - - - - - -
SP12: -
SP13:
SP14: - -
SP15:
SP16:
SP17: - -
SP18:
SP19:
SP20:

Relevant External Links for ST3GAL4 Gene

GeneLoc Exon Structure for
ST3GAL4
ECgene alternative splicing isoforms for
ST3GAL4

Expression for ST3GAL4 Gene

mRNA expression in normal human tissues for ST3GAL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST3GAL4 Gene

This gene is overexpressed in Whole Blood (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ST3GAL4 Gene

SOURCE GeneReport for Unigene cluster for ST3GAL4 Gene Hs.591947

mRNA Expression by UniProt/SwissProt for ST3GAL4 Gene

Q11206-SIA4C_HUMAN
Tissue specificity: Highly expressed in adult placenta, ovary and testes
genes like me logo Genes that share expressions with ST3GAL4: view

Orthologs for ST3GAL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST3GAL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST3GAL4 36
  • 99.28 (n)
  • 99.07 (a)
ST3GAL4 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ST3GAL-IV 37
  • 89 (a)
OneToOne
ST3GAL4 36
  • 89.79 (n)
  • 89.19 (a)
dog
(Canis familiaris)
Mammalia ST3GAL4 36
  • 91.59 (n)
  • 93.69 (a)
ST3GAL4 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St3gal4 36
  • 85.89 (n)
  • 89.49 (a)
St3gal4 16
St3gal4 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ST3GAL4 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 65 (a)
OneToMany
-- 37
  • 58 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia St3gal4 36
  • 85.89 (n)
  • 90.09 (a)
chicken
(Gallus gallus)
Aves ST3GAL4 36
  • 76.02 (n)
  • 76.52 (a)
ST3GAL4 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST3GAL4 37
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15272 36
tropical clawed frog
(Silurana tropicalis)
Amphibia st3gal4 36
  • 62.6 (n)
  • 63.04 (a)
zebrafish
(Danio rerio)
Actinopterygii st3gal4 36
  • 58.42 (n)
  • 56.36 (a)
st3gal4 37
  • 49 (a)
OneToOne
Species with no ortholog for ST3GAL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST3GAL4 Gene

ENSEMBL:
Gene Tree for ST3GAL4 (if available)
TreeFam:
Gene Tree for ST3GAL4 (if available)

Paralogs for ST3GAL4 Gene

Paralogs for ST3GAL4 Gene

Selected SIMAP similar genes for ST3GAL4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ST3GAL4: view

Variants for ST3GAL4 Gene

Sequence variations from dbSNP and Humsavar for ST3GAL4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs601698 -- 126,364,557(+) CAGGT(A/G)TTGGG intron-variant
rs601713 -- 126,364,569(+) TGGAT(G/T)TGGGA intron-variant
rs617120 -- 126,364,568(+) CTGGA(C/T)GTGGG intron-variant
rs617707 -- 126,365,823(+) GAGAC(A/G)GGCCC intron-variant
rs617731 -- 126,359,276(+) TTATT(A/T)AAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST3GAL4 Gene

Variant ID Type Subtype PubMed ID
nsv898442 CNV Gain 21882294
nsv826123 CNV Gain 20364138
esv24669 CNV Gain 19812545
nsv527257 CNV Gain 19592680
esv2745215 CNV Deletion 23290073
esv2672750 CNV Deletion 23128226

Relevant External Links for ST3GAL4 Gene

HapMap Linkage Disequilibrium report
ST3GAL4

Disorders for ST3GAL4 Gene

(33) Novoseek inferred disease relationships for ST3GAL4 Gene

Disease -log(P) Hits PubMed IDs
hyperglycemia 77.9 35
diabetes mellitus 58.3 10
diabetes mellitus insulin-dependent 49.4 8
diabetic nephropathies 47.4 4
hyperlipidemia 45.1 2

Relevant External Links for ST3GAL4

Genetic Association Database (GAD)
ST3GAL4
Human Genome Epidemiology (HuGE) Navigator
ST3GAL4
genes like me logo Genes that share disorders with ST3GAL4: view

No data available for UniProtKB/Swiss-Prot for ST3GAL4 Gene

Publications for ST3GAL4 Gene

  1. Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT- 3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP- NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line. (PMID: 8611500) Basu S.S. … Basu S. (Biochemistry 1996) 3 4 23
  2. Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups. (PMID: 8288606) Kitagawa H. … Paulson J.C. (J. Biol. Chem. 1994) 2 3 4
  3. Genomic organization and chromosomal mapping of the Gal beta 1,3GalNAc/Gal beta 1,4GlcNAc alpha 2,3-sialyltransferase. (PMID: 8557707) Kitagawa H. … Paulson J.C. (J. Biol. Chem. 1996) 2 3 4
  4. Identification of nine alternatively spliced alpha2,3- sialyltransferase, ST3Gal IV, transcripts and analysis of their expression by RT-PCR and laser-induced fluorescent capillary electrophoresis (LIF-CE) in twenty-one human tissues. (PMID: 12441665) Grahn A. … Larson G. (Glycoconj. J. 2001) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ST3GAL4 Gene

Sources for ST3GAL4 Gene

Back to Top

Content