ST3GAL3 Gene
protein-coding GIFtS: 57
GCID: GC01P044173
|
|
ST3 beta-galactoside alpha-2,3-sialyltransferase 3(Previous name: sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase)...)
(Previous symbol: SIAT6)
| |
Aliases
for ST3GAL3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 31 2 | | Alpha 2,3-Sialyltransferase III2 | | SIAT61 2 3 5 | | Alpha-2,3-Sialyltransferase II2 | | Sialyltransferase 6 (N-Acetyllacosaminide Alpha 2,3-Sialyltransferase)1 2 | | CMP-N-Acetylneuraminate-Beta-1,4-Galactoside Alpha-2,3-Sialyltransferase2 | | Alpha 2,3-ST 32 3 | | Gal Beta-1,3(4)GlcNAc Alpha-2,3 Sialyltransferase2 | | ST3GalIII2 3 | | EC 2.4.99.63 | | ST3N2 3 | | Beta-Galactoside Alpha-2,3-Sialyltransferase 33 | | ST3Gal III2 3 | | Gal Beta-1,3(4) GlcNAc Alpha-2,3 Sialyltransferase3 | | ST3GALII2 5 | | N-Acetyllactosaminide Alpha-2,3-Sialyltransferase3 | | EIEE152 | | Sialyltransferase 63 | | MRT122 | | |
Export aliases for ST3GAL3 gene to outside databasesPrevious GC identifers: GC01P043844 GC01P043946 GC01P042293 |
Summaries
for ST3GAL3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ST3GAL3:
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid fromCMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi apparatus butcan be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29.Mutations in this gene have been associated with autosomal recessive nonsymdromic mental retardation-12 (MRT12).Multiple transcript variants encoding several different isoforms have been found for this gene. (provided by RefSeq,Jul 2012)
UniProtKB/Swiss-Prot: SIAT6_HUMAN, Q11203Function: Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- orNeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids.The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc (By similarity)
Gene Wiki entry for ST3GAL3
|
Genomic Views
for ST3GAL3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ST3GAL3 gene promoter:
TBP
Other transcription factors
Search SABiosciences Chromatin IP Primers for ST3GAL3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST3GAL3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p34.1 Ensembl cytogenetic band: 1p34.1 HGNC cytogenetic band: 1p34.1ST3GAL3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P044173: view genomic region
(about GC identifiers)
Start:
|
44,171,495 bp from pter |
End:
|
44,396,831 bp from pter |
Size:
|
225,337 bases |
Orientation:
|
plus strand |
|
Proteins
for ST3GAL3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SIAT6_HUMAN, Q11203 (See
protein sequence)Recommended Name: CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase Size: 375 amino acids; 42171 Da
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted.Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid
Secondary accessions: A9Z1W2 D3DPX8 Q5T4W9 Q5T4X0 Q5T4X7 Q5T4X8 Q5T4X9 Q5T4Y0 Q5T4Y2 Q5T4Y3 Q5T4Y4Q86UR6 Q86UR7 Q86UR8 Q86UR9 Q86US0 Q86US1 Q86US2 Q8IX41 Q8IX42 Q8IX43 Q8IX44 Q8IX45 Q8IX46 Q8IX47Q8IX48 Q8IX49 Q8IX50 Q8IX51 Q8IX52 Q8IX53 Q8IX54 Q8IX55 Q8IX56 Q8IX57 Q8IX58Alternative splicing: 26 isoforms: Q11203-1 Q11203-2 Q11203-3 Q11203-4 Q11203-5 Q11203-6 Q11203-7 Q11203-8 Q11203-9 Q11203-10 Q11203-11 Q11203-12 Q11203-13 Q11203-14 Q11203-15 Q11203-16 Q11203-17 Q11203-18 Q11203-19 Q11203-20 Q11203-21 Q11203-22 Q11203-23 Q11203-24 Q11203-25 Q11203-26 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)Explore the universe of human proteins at neXtProt for ST3GAL3: NX_Q11203
Post-translational modifications:
The soluble form derives from the membrane form by proteolytic processing1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q11203
ST3GAL3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (18 alternative transcripts):
NP_001257388.1 NP_001257389.1 NP_001257390.1 NP_001257391.1 NP_001257392.1 NP_001257393.1 NP_001257394.1 NP_001257395.1 NP_006270.1 NP_777623.2 NP_777624.1 NP_777625.1 NP_777626.1 NP_777627.1 NP_777628.2 NP_777629.1 NP_777630.1 NP_777631.2
ENSEMBL proteins: ENSP00000431816 ENSP00000437206 ENSP00000434686 ENSP00000355341 ENSP00000354748 ENSP00000432214 ENSP00000317192 ENSP00000433668 ENSP00000355201 ENSP00000361437 ENSP00000435603 ENSP00000361444 ENSP00000354657 ENSP00000361442 ENSP00000361441 ENSP00000361440 ENSP00000361443 ENSP00000361447 ENSP00000435018 ENSP00000431700 ENSP00000434876 ENSP00000432682 ENSP00000432965 ENSP00000435621 ENSP00000432071 ENSP00000437293 ENSP00000329755 ENSP00000434378 ENSP00000436298 ENSP00000262915 ENSP00000361450 ENSP00000316999 ENSP00000361449 ENSP00000330463 ENSP00000439634 ENSP00000333494 ENSP00000335633 ENSP00000361452 Reactome Protein details: Q11203
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
ST3GAL3 for ontologies About GeneDecksing
ST3GAL3 Antibody Products:
Assay Products for ST3GAL3: |
Protein
Domains /
Families
for ST3GAL3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ST3GAL3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q11203ProtoNet protein and cluster: Q11203 1 Blocks protein family: IPB001675 Glycosyl transferase
UniProtKB/Swiss-Prot: SIAT6_HUMAN, Q11203Similarity: Belongs to the glycosyltransferase 29 family |
Function
for ST3GAL3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SIAT6_HUMAN, Q11203Function: Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- orNeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids.The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc (By similarity)Catalytic activity: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-glycoprotein = CMP +alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-glycoproteinEnzyme Number (IUBMB): EC 2.4.99.61
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ST3GAL3 (see all 13)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ST3GAL3 (see all 11)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 10): ST3GAL3 (NM_006279) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ST3GAL3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST3GAL3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST3GAL3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity |
IEA | -- | | GO:0008118 | N-acetyllactosaminide alpha-2,3-sialyltransferase activity |
IEA | -- |
ST3GAL3 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out St3gal3tm1Jxm for ST3GAL3
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for St3gal3):
ST3GAL3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ST3GAL3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | MPS IIIC - Sanfilippo syndrome C | | | 2 | Keratan sulfate biosynthesis | | | 3 | Metabolism | | | 4 | Pre-NOTCH Processing in Golgi | | | 5 | Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/26 
Reactome Pathways for ST3GAL3 (see all 26)
4 
Kegg Pathways (Kegg details for ST3GAL3):
UniProtKB/Swiss-Prot: SIAT6_HUMAN, Q11203Pathway: Protein modification; protein glycosylation
ST3GAL3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ST3GAL3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/41 Interacting proteins for ST3GAL3 (Q112032, 3 ENSP000002629154) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005975 | carbohydrate metabolic process |
TAS | -- | | GO:0006486 | protein glycosylation |
-- | -- | | GO:0016266 | O-glycan processing |
TAS | -- | | GO:0018146 | keratan sulfate biosynthetic process |
TAS | -- | | GO:0030203 | glycosaminoglycan metabolic process |
TAS | -- |
ST3GAL3 for ontologies About GeneDecksing
|
Drugs & Compounds
for ST3GAL3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ST3GAL3 for compounds About GeneDecksing
 Browse Tocris compounds for ST3GAL3
2 HMDB Compounds for ST3GAL3 About this table
3 Novoseek chemical compound relationships for ST3GAL3 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| sialic acid |
71.9 |
2 |
19418726 (1), 8611500 (1) |
| galactose |
36.8 |
1 |
9838208 (1) |
| polysaccharide |
31.5 |
3 |
1417784 (2), 7737417 (1) |
Search CenterWatch for drugs/clinical trials and news about ST3GAL3 / SIAT6
|
Transcripts
for ST3GAL3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ST3GAL3 gene (19 alternative transcripts): NM_001270459.1 NM_001270460.1 NM_001270461.1 NM_001270462.1 NM_001270463.1 NM_001270464.1 NM_001270465.1 NM_001270466.1 NM_006279.3 NM_174963.3 NM_174964.2 NM_174965.2 NM_174966.2 NM_174967.2 NM_174968.3 NM_174969.2 NM_174970.2 NM_174971.3 NM_174972.1 Unigene Cluster for ST3GAL3: ST3 beta-galactoside alpha-2,3-sialyltransferase 3 Hs.597915 [show with all ESTs]Unigene Representative Sequence: NM_17496318/41 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 41): ENST00000532911(uc009vwu.1) ENST00000489897 ENST00000530154(uc010okj.1)
ENST00000361392(uc001ckc.3 uc001ckg.3 uc001cki.3 uc009vwv.3 uc001ckj.3 uc001ckk.3 uc001ckl.3 uc009vwx.3 uc009vwz.3 uc001ckn.3)
ENST00000361400(uc001cka.3 uc001cke.3 uc009vww.3 uc009vwy.3 uc001cko.3 uc009vxa.3 uc001ckq.3 uc001ckr.3 uc009vxb.3)
ENST00000479383 ENST00000347631 ENST00000484868 ENST00000461066 ENST00000361812
ENST00000372362 ENST00000531451 ENST00000372369 ENST00000361746 ENST00000372367
ENST00000372366 ENST00000372365 ENST00000372368
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ST3GAL3 (see all 13)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ST3GAL3 (see all 11)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 10): ST3GAL3 (NM_006279) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ST3GAL3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST3GAL3 |
Additional cDNA sequence: AK301829.1 AK310265.1 AY051143.1 AY167993.1 AY167994.1 AY167995.1 AY167997.1 AY167998.1 BC050380.1 L23768.1 NR_073016.1 NR_073017.1 NR_073018.1 NR_073019.1 NR_073020.1 NR_073021.1 NR_073023.1 18 DOTS entries: DT.97781971 DT.100025325 DT.100883676 DT.92427640 DT.100883683 DT.100883687 DT.95173416 DT.113751 DT.100883674 DT.100883686 DT.75189663 DT.100883681 DT.75115324 DT.97813188 DT.100883672 DT.95173418 DT.91719015 DT.92427643 24/185 AceView cDNA sequences (see all 185): NM_174969 NM_174971 CR613052 AF425863 BE219744 AI002842 AA868006 BU189955 NM_174964 AY167995 AF425858 BI917861 AF425857 AF425868 AF425860 BC050380 AY167993 BQ876687 BQ653434 NM_174966 CA950994 AF425852 BQ109450 BU162619
GeneLoc Exon Structure
5/27 Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL3 (see all 27) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | | | - | | - | | - | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | | | - | | - | | - | | | | | | - | | - | | | | | | | | | | | |
| ExUns: | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | · | 21c | ^ | 22 | ^ | 23a | · | 23b | · | 23c |
|---|
|
| SP1: | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP2: | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP3: | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ST3GAL3
|
Expression
for ST3GAL3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ST3GAL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGCAATAA
About this image
See ST3GAL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ST3GAL3
SOURCE GeneReport for Unigene cluster: Hs.597915
UniProtKB/Swiss-Prot: SIAT6_HUMAN, Q11203Tissue specificity: Highly expressed in adult skeletal muscle and in all fetal tissues examined and to a much lesserextent in placenta, lung and liver
SABiosciences Custom PCR Arrays for ST3GAL3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ST3GAL3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ST3GAL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ST3GAL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST3GAL3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST3GAL3 |
Orthologs
for ST3GAL3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ST3GAL3 gene from 4/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ST3GAL31 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 3 |
74.15(n)
82.4(a) |
|
424572 XM_001233559.2 XP_001233560.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ST3GAL36 |
-- |
89(a) |
1 ↔ 1 |
4(108655580-108753175) |
African clawed frog
(Xenopus laevis) |
Amphibia |
st3Gal-III2 |
alpha2,3-sialyltransferase |
76.98(n) |
|
AJ585764.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc639782 |
hypothetical protein MGC63978 |
72.97(n) |
|
393326 BC053179.1 |
ENSEMBL Gene Tree for ST3GAL3 (if available)
TreeFam Gene Tree for ST3GAL3 (if available) |
Paralogs
for ST3GAL3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ST3GAL3 gene
- ST6GALNAC12 ST3GAL62 ST6GALNAC22 ST3GAL12 ST3GAL42 ST3GAL52 ST3GAL22
5 SIMAP similar genes for ST3GAL3 using alignment to 6 protein entries: SIAT6_HUMAN (see all proteins):ST3GalIII ST3GAL6 ST3GAL5 SIAT4C ST3GAL4
ST3GAL3 for paralogs About GeneDecksing
|
Genomic Variants
for ST3GAL3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ST3GAL3 (44171495 - 44396831 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for ST3GAL3
5 Indels: 68494 24207 74466 24208 84202
Human Gene Mutation Database (HGMD): ST3GAL3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ST3GAL3 |
|
Disorders
/ Diseases
for ST3GAL3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ST3GAL3 for disorders About GeneDecksing
OMIM gene information: 606494
OMIM disorders: --
UniProtKB/Swiss-Prot: SIAT6_HUMAN, Q11203
Defects in ST3GAL3 are the cause of mental retardation autosomal recessive type 12 (MRT12) [MIM:611090].Mental retardation is characterized by significantly below average general intellectual functioning associated withimpairments in adaptative behavior and manifested during the developmental period
13  diseases for ST3GAL3: About MalaCardscervical intraepithelial neoplasia gastric cancer choriocarcinoma colon carcinoma
cervicitis colon cancer ovarian cancer lung cancer
carcinoma breast cancer neuroblastoma immunodeficiency
alcoholism
4 Novoseek disease relationships for ST3GAL3 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gastric cancer |
11.2 |
2 |
12931020 (2) |
| carcinoma |
0.853 |
2 |
11389097 (1), 10673297 (1) |
| tumors |
0 |
5 |
12931020 (2) |
| cancer |
0 |
2 |
15231659 (1) |
Human Genome Epidemiology (HuGE) Navigator: ST3GAL3 (1 document)
Export disorders for ST3GAL3 gene to outside databases
|
Publications
for ST3GAL3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ST3GAL3 gene, integrated from 9 sources (see all 54):
(articles sorted by number of sources associating them with ST3GAL3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3- sialyltransferase. (PubMed id 8333853)1, 2, 3 Kitagawa H. and Paulson J.C. (1993)
- ST3GAL3 mutations impair the development of higher cognitive functions. (PubMed id 21907012)1, 2 Hu H....Kuss A.W. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Clinical relevance of sialyltransferases ST6GAL-I and ST3GAL-III in gastric cancer. (PubMed id 12931020)1, 9 Gretschel S....Kemmner W. (2003)
- Differential expression of alpha-2,3-sialyltransferas es and alpha-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a a nd sialyl Lewis x in gastrointestinal carcinoma cells. (PubMed id 19781661)1, 9 Carvalho A.S....Reis C.A. (2010)
- A genome-wide association study of aging. (PubMed id 21782286)1 Walter S....Franceschini N. (2011)
- Localization of Golgi-resident glycosyltransferases. (PubMed id 19727557)1 Tu L. and Banfield D.K. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
|
External Searches for ST3GAL3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ST3GAL3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ST3GAL3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ST3GAL3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ST3GAL3 | Pharmacogenomics, SNPs, Pathways | | GGDB | http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST3GAL3 | | Functional Glycomics Gateway - GTase | http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_624 |
|
| | |
About This Section
| Patent Information for ST3GAL3 gene:
Search GeneIP for patents involving ST3GAL3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ST3GAL3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ST3GAL3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ST3GAL3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ST3GAL3 | | | OriGene Protein Over-expression Lysate for ST3GAL3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ST3GAL3 | | OriGene 3'-UTR Clone for ST3GAL3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ST3GAL3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ST3GAL3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ST3GAL3 | | OriGene Custom Protein Services for ST3GAL3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ST3GAL3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ST3GAL3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST3GAL3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST3GAL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST3GAL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ST3GAL3 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ST3GAL3 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ST3GAL3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST3GAL3 |
|  |  |  | | | | ThermoFisher Antibodies for ST3GAL3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST3GAL3 |
|
|
|
|
