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Aliases for ST3GAL2 Gene

Aliases for ST3GAL2 Gene

  • ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2 2 3 5
  • Sialyltransferase 4B (Beta-Galactosidase Alpha-2,3-Sialytransferase) 2 3
  • Gal-Beta-1,3-GalNAc-Alpha-2,3-Sialyltransferase 3 4
  • Beta-Galactoside Alpha-2,3-Sialyltransferase 2 3 4
  • Alpha 2,3-ST 2 3 4
  • EC 2.4.99.4 4 61
  • Gal-NAc6S 3 4
  • ST3Gal II 3 4
  • ST3GalA.2 3 4
  • ST3GALII 3 4
  • SIAT4-B 3 4
  • SIAT4B 3 4
  • CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,3-Sialyltransferase 2 3
  • Sialyltransferase 4B 4
  • EC 2.4.99.7 61

External Ids for ST3GAL2 Gene

Previous HGNC Symbols for ST3GAL2 Gene

  • SIAT4B

Previous GeneCards Identifiers for ST3GAL2 Gene

  • GC16M068972
  • GC16M056246

Summaries for ST3GAL2 Gene

Entrez Gene Summary for ST3GAL2 Gene

  • The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4A. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST3GAL2 Gene

ST3GAL2 (ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2) is a Protein Coding gene. Diseases associated with ST3GAL2 include Kidney Fibrosarcoma. Among its related pathways are Keratan sulfate/keratin metabolism and Synthesis of substrates in N-glycan biosythesis. GO annotations related to this gene include sialyltransferase activity and beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. An important paralog of this gene is ST3GAL1.

UniProtKB/Swiss-Prot for ST3GAL2 Gene

  • It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST3GAL2 Gene

Genomics for ST3GAL2 Gene

Regulatory Elements for ST3GAL2 Gene

Enhancers for ST3GAL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G070426 2.1 FANTOM5 Ensembl ENCODE dbSUPER 9.6 +8.3 8286 8.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SP3 TBX21 MEF2D COG4 LOC400541 ST3GAL2 NPIPB14P PDXDC2P-NPIPB14P LOC100506083 FUK EXOSC6 CLEC18A SMG1P7
GH16G070436 1.4 ENCODE dbSUPER 0.7 +1.1 1097 3.9 CREB3L1 AGO1 FEZF1 YY1 SLC30A9 ZNF143 SP3 MEF2D SSRP1 ZNF610 SMG1P7 CLEC18A PDXDC2P-NPIPB14P SF3B3 LOC400541 NONOP1 PDXDC2P EXOSC6 COG4 PDPR
GH16G070444 0.8 ENCODE dbSUPER 0.4 -5.6 -5622 1.3 RCOR2 HLF ZIC2 SPI1 COG4 FUK RPS27P26 ST3GAL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ST3GAL2 on UCSC Golden Path with GeneCards custom track

Promoters for ST3GAL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000087567 237 2001 HDGF CREB3L1 ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 SLC30A9 ZNF766

Genomic Location for ST3GAL2 Gene

Chromosome:
16
Start:
70,375,978 bp from pter
End:
70,439,237 bp from pter
Size:
63,260 bases
Orientation:
Minus strand

Genomic View for ST3GAL2 Gene

Genes around ST3GAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST3GAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST3GAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST3GAL2 Gene

Proteins for ST3GAL2 Gene

  • Protein details for ST3GAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16842-SIA4B_HUMAN
    Recommended name:
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
    Protein Accession:
    Q16842
    Secondary Accessions:
    • O00654

    Protein attributes for ST3GAL2 Gene

    Size:
    350 amino acids
    Molecular mass:
    40173 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST3GAL2 Gene

Selected DME Specific Peptides for ST3GAL2 Gene

Q16842:
  • CRRCAVVGNSGNL
  • WHHYWENN
  • FRKTGVHDADFE
  • RMNQAPTVGFE
  • HGRYPSTG
  • DVGSRTTHH
  • YGFGADS

Post-translational modifications for ST3GAL2 Gene

  • The soluble form derives from the membrane form by proteolytic processing.
  • Glycosylation at isoforms=92 and posLast=211211
  • Modification sites at PhosphoSitePlus

Other Protein References for ST3GAL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ST3GAL2 ("ST3 beta-Gal alpha-2,3-Sialyltransferase 2/ST3GAL2")

Domains & Families for ST3GAL2 Gene

Gene Families for ST3GAL2 Gene

Protein Domains for ST3GAL2 Gene

Suggested Antigen Peptide Sequences for ST3GAL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16842

UniProtKB/Swiss-Prot:

SIA4B_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST3GAL2: view

Function for ST3GAL2 Gene

Molecular function for ST3GAL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R.
UniProtKB/Swiss-Prot Function:
It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.

Enzyme Numbers (IUBMB) for ST3GAL2 Gene

Gene Ontology (GO) - Molecular Function for ST3GAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity TAS --
GO:0008373 sialyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ST3GAL2: view
genes like me logo Genes that share phenotypes with ST3GAL2: view

Animal Models for ST3GAL2 Gene

MGI Knock Outs for ST3GAL2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ST3GAL2

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ST3GAL2 Gene

Localization for ST3GAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST3GAL2 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST3GAL2 gene
Compartment Confidence
golgi apparatus 5
extracellular 4
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ST3GAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST3GAL2: view

Pathways & Interactions for ST3GAL2 Gene

genes like me logo Genes that share pathways with ST3GAL2: view

UniProtKB/Swiss-Prot Q16842-SIA4B_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for ST3GAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006040 amino sugar metabolic process TAS 9266697
GO:0006464 cellular protein modification process TAS 9266697
GO:0006486 protein glycosylation IEA --
GO:0009311 oligosaccharide metabolic process IBA --
GO:0016266 O-glycan processing TAS --
genes like me logo Genes that share ontologies with ST3GAL2: view

No data available for SIGNOR curated interactions for ST3GAL2 Gene

Drugs & Compounds for ST3GAL2 Gene

(1) Drugs for ST3GAL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine monophosphate Experimental Pharma 0

(1) Additional Compounds for ST3GAL2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-Acetylneuraminate
  • CMP-N-Acylneuraminate
  • CMP-NeuNAc
  • Cytidine 5'-monophosphate N-acetylneuraminic acid
  • Cytidine Monophosphate N-Acetylneuraminate
22-12-8
genes like me logo Genes that share compounds with ST3GAL2: view

Transcripts for ST3GAL2 Gene

Unigene Clusters for ST3GAL2 Gene

ST3 beta-galactoside alpha-2,3-sialyltransferase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2:
SP3: - -
SP4: - -
SP5:

Relevant External Links for ST3GAL2 Gene

GeneLoc Exon Structure for
ST3GAL2
ECgene alternative splicing isoforms for
ST3GAL2

Expression for ST3GAL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST3GAL2 Gene

mRNA differential expression in normal tissues according to GTEx for ST3GAL2 Gene

This gene is overexpressed in Whole Blood (x7.5).

Protein differential expression in normal tissues from HIPED for ST3GAL2 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ST3GAL2 Gene



Protein tissue co-expression partners for ST3GAL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ST3GAL2 Gene:

ST3GAL2

SOURCE GeneReport for Unigene cluster for ST3GAL2 Gene:

Hs.368611

mRNA Expression by UniProt/SwissProt for ST3GAL2 Gene:

Q16842-SIA4B_HUMAN
Tissue specificity: Highly expressed in skeletal muscle and heart and to a much lesser extent in brain, placenta, liver and pancreas. Scarcely detectable in lung and kidney.

Evidence on tissue expression from TISSUES for ST3GAL2 Gene

  • Liver(4.2)
  • Lung(4.2)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with ST3GAL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST3GAL2 Gene

Orthologs for ST3GAL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST3GAL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST3GAL2 34 35
  • 98.95 (n)
cow
(Bos Taurus)
Mammalia SIAT4B 35
  • 96 (a)
OneToOne
ST3GAL2 34
  • 92.48 (n)
oppossum
(Monodelphis domestica)
Mammalia ST3GAL2 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ST3GAL2 34 35
  • 91.9 (n)
mouse
(Mus musculus)
Mammalia St3gal2 34 16 35
  • 89.24 (n)
rat
(Rattus norvegicus)
Mammalia St3gal2 34
  • 88.1 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ST3GAL2 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves ST3GAL2 34 35
  • 82.71 (n)
lizard
(Anolis carolinensis)
Reptilia ST3GAL2 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st3gal2 34
  • 69.53 (n)
st3Gal-II 34
African clawed frog
(Xenopus laevis)
Amphibia st3Gal-II 34
zebrafish
(Danio rerio)
Actinopterygii st3gal2 34 35
  • 71.06 (n)
wufd05f03 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7280 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4378 35
  • 38 (a)
OneToMany
Species where no ortholog for ST3GAL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST3GAL2 Gene

ENSEMBL:
Gene Tree for ST3GAL2 (if available)
TreeFam:
Gene Tree for ST3GAL2 (if available)

Paralogs for ST3GAL2 Gene

(1) SIMAP similar genes for ST3GAL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ST3GAL2: view

Variants for ST3GAL2 Gene

Sequence variations from dbSNP and Humsavar for ST3GAL2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs386352366 Uncertain significance 70,395,174(-) ACAGA(C/T)GCTGC reference, missense
rs1000039248 -- 70,408,034(+) GAGGA(C/T)GTGTC intron-variant
rs1000105845 -- 70,429,097(+) GCCCC(C/G)TCAGC intron-variant
rs1000149589 -- 70,393,667(+) ATCTC(C/G)CTCCC intron-variant
rs1000175288 -- 70,434,446(+) AAAAA(-/C)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST3GAL2 Gene

Variant ID Type Subtype PubMed ID
esv3638954 CNV loss 21293372
esv3638955 CNV loss 21293372
esv3892881 CNV gain 25118596
nsv1116156 CNV deletion 24896259
nsv7285 OTHER inversion 18451855
nsv833272 CNV loss 17160897

Variation tolerance for ST3GAL2 Gene

Residual Variation Intolerance Score: 10.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ST3GAL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST3GAL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST3GAL2 Gene

Disorders for ST3GAL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ST3GAL2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
kidney fibrosarcoma
  • fibrosarcoma of the kidney
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ST3GAL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ST3GAL2
genes like me logo Genes that share disorders with ST3GAL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST3GAL2 Gene

Publications for ST3GAL2 Gene

  1. Cloning and expression of cDNA for a human Gal(beta1-3)GalNAc alpha2,3-sialyltransferase from the CEM T-cell line. (PMID: 9266697) Giordanengo V. … Lefebvre J.-C. (Eur. J. Biochem. 1997) 2 3 4 64
  2. Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialyltransferase (hST3Gal II). (PMID: 8920913) Kim Y.-J. … Lee Y.-C. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase. (PMID: 12716912) Saito S. … Miyagi T. (J. Biol. Chem. 2003) 3 22 64
  5. Critical role of evolutionarily conserved glycosylation at Asn211 in the intracellular trafficking and activity of sialyltransferase ST3Gal-II. (PMID: 25916169) Ruggiero F.M. … Daniotti J.L. (Biochem. J. 2015) 3 64

Products for ST3GAL2 Gene

Sources for ST3GAL2 Gene

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