Aliases for ST3GAL2 Gene
External Ids for ST3GAL2 Gene
Previous HGNC Symbols for ST3GAL2 Gene
Previous GeneCards Identifiers for ST3GAL2 Gene
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4A. [provided by RefSeq, Jul 2008]
GeneCards Summary for ST3GAL2 Gene
ST3GAL2 (ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2) is a Protein Coding gene. Diseases associated with ST3GAL2 include epileptic encephalopathy, early infantile, 15 and kidney fibrosarcoma. Among its related pathways are Keratan sulfate/keratin metabolism and Glycosphingolipid biosynthesis - ganglio series. GO annotations related to this gene include sialyltransferase activity and beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. An important paralog of this gene is ST3GAL4.
UniProtKB/Swiss-Prot for ST3GAL2 Gene
It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.