ST3GAL2 Gene

Aliases
for ST3GAL2 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC16M068972 GC16M056246

Summaries
for ST3GAL2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for ST3GAL2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000016.9  NC_018927.2  NT_010498.16  

Browse SwitchGear Promoter luciferase reporter plasmids

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST3GAL2

ST3GAL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M070413:  view genomic region     (about GC identifiers)

Proteins
for ST3GAL2 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for ST3GAL2: NX_Q16842

Explore proteomics data for ST3GAL2 at MOPED

Post-translational modifications: 

ST3GAL2 Human Recombinant Protein Products:

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	antibodies-online proteins for ST3GAL2 (4 products)
	antibodies-online peptides for ST3GAL2

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	antibodies-online kits for ST3GAL2 (18 products)

Domains /
Families
for ST3GAL2 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q16842

Find genes that share domains with ST3GAL2           About GenesLikeMe

Function
for ST3GAL2 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Enzyme Numbers (IUBMB): EC 2.4.99.4^{1 2} EC 2.4.99.7²

     Gene Ontology (GO): 2 molecular function terms:    About this table

(inferred from 2 alleles) (MGI details for St3gal2)

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miRNA Products:		miRTarBase miRNAs that target ST3GAL2: hsa-mir-615-3p (MIRT039844), hsa-mir-324-3p (MIRT042983), hsa-mir-484 (MIRT042249), hsa-mir-760 (MIRT036742)
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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ST3GAL2

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST3GAL2

Localization
for ST3GAL2 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
golgi apparatus	5
cytosol	3
extracellular	2
endoplasmic reticulum	1
lysosome	1
peroxisome	1
plasma membrane	1

About this image

Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

Pathways & Interactions
for ST3GAL2 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for ST3GAL2 About   (see all 8)   See pathways by source

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	SuperPath	Selected contained pathways About (see all per SuperPath)
1	Keratan sulfate/keratin metabolism	Keratan sulfate/keratin metabolism 0.85 Glycosaminoglycan biosynthesis - keratan sulfate 0.43 Keratan sulfate biosynthesis 0.85
2	O-linked glycosylation of mucins	O-linked glycosylation of mucins 0.47 Termination of O-glycan biosynthesis 0.38 Mucin type O-Glycan biosynthesis 0.47
3	Glycosphingolipid biosynthesis - ganglio series	Ganglio Sphingolipid Metabolism 0.53 Glycosphingolipid biosynthesis - ganglio series 0.53
4	Metabolism	Metabolism 0.38 Metabolic pathways 0.38
5	MPS VI - Maroteaux-Lamy syndrome	MPS VI - Maroteaux-Lamy syndrome 0.45 MPS IV - Morquio syndrome B 0.45 MPS IIIC - Sanfilippo syndrome C 0.45 MPS IX - Natowicz syndrome 0.45 MPS IIID - Sanfilippo syndrome D 0.45 MPS IV - Morquio syndrome A 0.45 MPS IIIA - Sanfilippo syndrome A 0.45 Mucopolysaccharidoses 0.45

1 BioSystems Pathway for ST3GAL2

Ganglio Sphingolipid Metabolism

3 Reactome Pathways for ST3GAL2

	Sialic acid metabolism
	Keratan sulfate biosynthesis
	Termination of O-glycan biosynthesis

5 Kegg Pathways  (Kegg details for ST3GAL2)

	Mucin type O-Glycan biosynthesis
	Glycosaminoglycan biosynthesis - keratan sulfate
	Glycosphingolipid biosynthesis - globo series
	Glycosphingolipid biosynthesis - ganglio series
	Metabolic pathways

    Pathway & Disease-focused RT² Profiler PCR Array including ST3GAL2: 

Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

Drugs & Compounds
for ST3GAL2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for ST3GAL2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for ST3GAL2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ST3GAL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AATCCCGCCA

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for ST3GAL2 OriGene qSTAR qPCR primer pairs in human, mouse for ST3GAL2
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ST3GAL2
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST3GAL2

Orthologs
for ST3GAL2 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for ST3GAL2 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for ST3GAL2 gene

ST3GAL3²  ST6GALNAC1²  ST3GAL6²  ST6GALNAC2²  ST3GAL1²  ST3GAL4²  ST3GAL5²  

1 SIMAP similar gene for ST3GAL2 using alignment to 1 protein entry:     SIA4B_HUMAN:

ST3GAL1

Find genes that share paralogs with ST3GAL2           About GenesLikeMe

Genomic Variants
for ST3GAL2 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ST3GAL2 (see all 1223)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1170253051,2	C,F	--	70412862(+)	GGCCAT/CTGCAC	1	--	ds5001		1		EA	120
rs1445792871,2		--	70412935(+)	TGCGGC/GTTGCC	1	--	ds5001		0	--	--	--	--
rs1162960941,2	F	--	70412945(+)	CTGTGG/ACATGG	1	--	ds5001		1		WA	118
rs1807530661,2		--	70412964(+)	GGGCTA/GTGGAG	1	--	ds5001		0	--	--	--	--
rs1397715571,2		--	70412995(+)	AAAACC/GTGACT	1	--	ds5001		0	--	--	--	--
rs771498521,2	C,F	--	70413048(+)	CCACCC/TAAATG	1	--	ds5001		1		WA	118
rs1453356611,2		--	70413054(+)	AAATGC/TATCGG	1	--	ds5001		0	--	--	--	--
rs1860155431,2		--	70413074(+)	GATACC/TTGGAG	1	--	ds5001		0	--	--	--	--
rs1476716871,2		--	70413146(+)	GAATCC/TTCTCC	1	--	ds5001		0	--	--	--	--
rs1407494311,2		--	70413180(+)	ACTCAA/GGAGGC	1	--	ds5001		0	--	--	--	--

HapMap Linkage Disequilibrium report for ST3GAL2 (70413338 - 70473140 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for ST3GAL2:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv833272	CNV	Loss	17160897
nsv7285	OTHER	Inversion	18451855

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ST3GAL2

DNA2.0 Custom Variant and Variant Library Synthesis for ST3GAL2

Disorders / Diseases
for ST3GAL2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for ST3GAL2 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ST3GAL2 gene, integrated from 10 sources (see all 20): (articles sorted by number of sources associating them with ST3GAL2)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning and expression of cDNA for a human Gal(beta1-3)GalNAc alpha2,3-sialyltransferase from the CEM T-cell line. (PubMed id 9266697)^{1, 2, 3} Giordanengo V. and Lefebvre J.-C. (Eur. J. Biochem. 1997)
2. Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialyltransferase (hST3Gal II). (PubMed id 8920913)^{1, 2, 3} Kim Y.-J.... Lee Y.-C. (Biochem. Biophys. Res. Commun. 1996)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
4. Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase. (PubMed id 12716912)^{1, 9} Saito S....Miyagi T. (J. Biol. Chem. 2003)
5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (amp 2008)
6. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (Cell 2005)
7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (Nat. Genet. 2004)
8. Genomic structure, expression, and transcriptional regulation of human Gal beta 1,3 GalNAc alpha 2,3-sialyltransferase gene. (PubMed id 12504121)¹ Taniguchi A....Matsumoto K. (Biochem. Biophys. Res. Commun. 2003)
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
10. Three genes that encode human beta-galactoside alpha 2,3- sialyltransferases. Structural analysis and chromosomal mapping studies. (PubMed id 7655169)¹ Chang M.-L.... Lau J.T.Y. (Glycobiology 1995)

External Searches for ST3GAL2 gene

Genome Databases showing ST3GAL2 gene

Other Databases showing ST3GAL2 gene

Specialized Databases showing ST3GAL2 gene

Products
for ST3GAL2 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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