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ST3GAL2 Gene

protein-coding   GIFtS: 60
GCID: GC16M070413

ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2

(Previous name: sialyltransferase 4B (beta-galactosidase alpha-2,3-sialytransferase))
(Previous symbol: SIAT4B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 21 2     ST3Gal II2 3
SIAT4B1 2 3     EC 2.4.99.43 8
Sialyltransferase 4B (Beta-Galactosidase Alpha-2,3-Sialytransferase)1 2     ST3GALII2
Alpha 2,3-ST 22 3     Beta-Galactoside Alpha-2,3-Sialytransferase2
Beta-Galactoside Alpha-2,3-Sialyltransferase 22 3     CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,3-Sialyltransferase 22
Gal-NAc6S2 3     ST3GalII3
Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase2 3     Sialyltransferase 4B3
SIAT4-B2 3     EC 2.4.99.78
ST3GalA.22 3     

External Ids:    HGNC: 108631   Entrez Gene: 64832   Ensembl: ENSG000001573507   OMIM: 6071885   UniProtKB: Q168423   
ORGUL members:         

Export aliases for ST3GAL2 gene to outside databases

Previous GC identifers: GC16M068972 GC16M056246


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ST3GAL2 Gene:
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from
CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be
proteolytically processed to a soluble form. This protein, which is a member of glycosyltransferase family 29,
can use the same acceptor substrates as does sialyltransferase 4A. (provided by RefSeq, Jul 2008)

GeneCards Summary for ST3GAL2 Gene:
ST3GAL2 (ST3 beta-galactoside alpha-2,3-sialyltransferase 2) is a protein-coding gene. Diseases associated with ST3GAL2 include kidney fibrosarcoma, and fibrosarcoma. GO annotations related to this gene include beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. An important paralog of this gene is ST3GAL3.

UniProtKB/Swiss-Prot: SIA4B_HUMAN, Q16842
Function: It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in
terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B
sialylate the same acceptor substrates but exhibit different Km values




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ST3GAL2 gene promoter:
         MAZR   FOXF2   p53   Olf-1   IRF-1   CUTL1   C/EBPalpha   PPAR-alpha   HOXA5   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ST3GAL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST3GAL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.3

ST3GAL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST3GAL2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M070413:  view genomic region     (about GC identifiers)

Start:
70,413,338 bp from pter      End:
70,473,140 bp from pter
Size:
59,803 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIA4B_HUMAN, Q16842 (See protein sequence)
Recommended Name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2  
Size: 350 amino acids; 40173 Da
Secondary accessions: O00654

Explore the universe of human proteins at neXtProt for ST3GAL2: NX_Q16842

Explore proteomics data for ST3GAL2 at MOPED

Post-translational modifications: 

  • The soluble form derives from the membrane form by proteolytic processing (By similarity)1
  • Glycosylation2 at Asn211
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ST3GAL2 (Q16842) (see all 7)
     YGFGADS  WHHYWENN  HGRYPSTG  DVGSRTTHH 


    See ST3GAL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008858.1  
    ENSEMBL proteins: 
     ENSP00000377257   ENSP00000345477  
    Reactome Protein details: Q16842

    ST3GAL2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ST3G: Sialyltransferases

    2 InterPro protein domains:
     IPR001675 Glyco_trans_29
     IPR012163 Sialyl_trans

    Graphical View of Domain Structure for InterPro Entry Q16842

    ProtoNet protein and cluster: Q16842

    1 Blocks protein domain: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIA4B_HUMAN, Q16842
    Similarity: Belongs to the glycosyltransferase 29 family


    ST3GAL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIA4B_HUMAN, Q16842
    Function: It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in
    terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B
    sialylate the same acceptor substrates but exhibit different Km values
    Catalytic activity: CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP +
    alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R

         Enzyme Numbers (IUBMB): EC 2.4.99.41 2 EC 2.4.99.72

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003836beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IEA--
    GO:0008373sialyltransferase activity ----
         
    ST3GAL2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for St3gal2):
     hematopoietic system  normal 

    ST3GAL2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out St3gal2tm1Jxm for ST3GAL2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ST3GAL2
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    miRNA
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    miRTarBase miRNAs that target ST3GAL2:
    hsa-mir-615-3p (MIRT039844), hsa-mir-324-3p (MIRT042983), hsa-mir-484 (MIRT042249), hsa-mir-760 (MIRT036742)

    Block miRNA regulation of human, mouse, rat ST3GAL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ST3GAL2 (see all 50):
    hsa-miR-3678-3p hsa-miR-429 hsa-miR-513a-5p hsa-miR-25 hsa-miR-765 hsa-miR-877* hsa-miR-9 hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidST3GAL2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIA4B_HUMAN, Q16842: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (By similarity).
    Secreted (By similarity). Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol3
    extracellular2
    endoplasmic reticulum1
    lysosome1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus ----
    GO:0030173integral component of Golgi membrane IEA--

    ST3GAL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ST3GAL2 About   (see all 8)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Keratan sulfate/keratin metabolism
    Keratan sulfate/keratin metabolism0.85
    Glycosaminoglycan biosynthesis - keratan sulfate0.43
    Keratan sulfate biosynthesis0.85
    2O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.47
    Termination of O-glycan biosynthesis0.38
    Mucin type O-Glycan biosynthesis0.47
    3Glycosphingolipid biosynthesis - ganglio series
    Ganglio Sphingolipid Metabolism0.53
    Glycosphingolipid biosynthesis - ganglio series0.53
    4Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    5MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ST3GAL2
        Ganglio Sphingolipid Metabolism


    3 Reactome Pathways for ST3GAL2
        Sialic acid metabolism
    Keratan sulfate biosynthesis
    Termination of O-glycan biosynthesis


    5 Kegg Pathways  (Kegg details for ST3GAL2):
        Mucin type O-Glycan biosynthesis
    Glycosaminoglycan biosynthesis - keratan sulfate
    Glycosphingolipid biosynthesis - globo series
    Glycosphingolipid biosynthesis - ganglio series
    Metabolic pathways

    UniProtKB/Swiss-Prot: SIA4B_HUMAN, Q16842
    Pathway: Protein modification; protein glycosylation


    ST3GAL2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ST3GAL2: 

              Glycosylation in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ST3GAL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ST3GAL2 (Q168422, 3 ENSP000003454774) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENO2P091042, 3MINT-63434 I2D: score=4 
    B3GALT5ENSP000003433184STRING: ENSP00000343318
    C1GALT1ENSP000002231224STRING: ENSP00000223122
    ENSG00000236802ENSP000004148804STRING: ENSP00000414880
    FUT1ENSP000003120214STRING: ENSP00000312021
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006040amino sugar metabolic process TAS9266697
    GO:0006464cellular protein modification process TAS9266697
    GO:0006486protein glycosylation ----
    GO:0016266O-glycan processing TAS--

    ST3GAL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ST3GAL2 (SIA4B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ST3GAL2 gene: 
    NM_006927.3  

    Unigene Cluster for ST3GAL2:

    ST3 beta-galactoside alpha-2,3-sialyltransferase 2
    Hs.368611  [show with all ESTs]
    Unigene Representative Sequence: AK127322
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393640(uc002eyw.2) ENST00000567822 ENST00000566097 ENST00000561708
    ENST00000567586 ENST00000342907(uc002eyx.2)
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    hsa-miR-3678-3p hsa-miR-429 hsa-miR-513a-5p hsa-miR-25 hsa-miR-765 hsa-miR-877* hsa-miR-9 hsa-miR-1184
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    Additional mRNA sequence: 

    AF086257.1 AK127322.1 AK313020.1 BC036777.1 BC064480.1 U63090.1 X96667.1 

    9 DOTS entries:

    DT.99989994  DT.310837  DT.100715956  DT.100751685  DT.407132  DT.120687421  DT.120687458  DT.95342472 
    DT.100751686 

    Selected AceView cDNA sequences (see all 143):

    AI962559 AA564366 AL134178 BX099248 BU074422 AI097613 CD674963 AW027254 
    BQ898848 AW043871 AI382279 AW007025 BU657735 AK127322 BF058186 AU142783 
    AA709312 BM699410 AI383394 NM_006927 CD675612 AF086257 BM920376 BU158526 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                                  -                                             
    SP2:                                                                                                
    SP3:        -           -                                                                           
    SP4:              -     -                                                                           
    SP5:                                                                                                


    ECgene alternative splicing isoforms for ST3GAL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ST3GAL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATCCCGCCA
    ST3GAL2 Expression
    About this image

    ST3GAL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ST3GAL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368611

    UniProtKB/Swiss-Prot: SIA4B_HUMAN, Q16842
    Tissue specificity: Highly expressed in skeletal muscle and heart and to a much lesser extent in brain, placenta,
    liver and pancreas. Scarcely detectable in lung and kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including ST3GAL2: 
              Glycosylation in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST3GAL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ST3GAL2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St3gal21 , 5 ST3 beta-galactoside alpha-2,3-sialyltransferase 21, 5 89.24(n)1
    94.29(a)1
      8 (57.81 cM)5
    204441  NM_009179.31  NP_033205.21 
     1109199225 
    chicken
    (Gallus gallus)
    Aves ST3GAL21 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 82.71(n)
    86.46(a)
      395139  NM_204480.2  NP_989811.2 
    lizard
    (Anolis carolinensis)
    Reptilia ST3GAL26
    ST3 beta-galactoside alpha-2,3-sialyltransferase 2...
    76(a)
    1 ↔ 1
    GL343539.1(323-8855)
    African clawed frog
    (Xenopus laevis)
    Amphibia st3Gal-II2 alpha2,3-sialyltransferase 73.08(n)    AJ585762.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd05f032 Transcribed sequence with weak similarity to protein more 74.32(n)    57054817 


    ENSEMBL Gene Tree for ST3GAL2 (if available)
    TreeFam Gene Tree for ST3GAL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ST3GAL2 gene
    ST3GAL32  ST6GALNAC12  ST3GAL62  ST6GALNAC22  ST3GAL12  ST3GAL42  ST3GAL52  
    1 SIMAP similar gene for ST3GAL2 using alignment to 1 protein entry:     SIA4B_HUMAN:
    ST3GAL1

    ST3GAL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ST3GAL2 (see all 1223)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1170253051,2
    C,F--70412862(+) GGCCAT/CTGCAC 1 -- ds50011Minor allele frequency- C:0.04EA 120
    rs1445792871,2
    --70412935(+) TGCGGC/GTTGCC 1 -- ds50010--------
    rs1162960941,2
    F--70412945(+) CTGTGG/ACATGG 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1807530661,2
    --70412964(+) GGGCTA/GTGGAG 1 -- ds50010--------
    rs1397715571,2
    --70412995(+) AAAACC/GTGACT 1 -- ds50010--------
    rs771498521,2
    C,F--70413048(+) CCACCC/TAAATG 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1453356611,2
    --70413054(+) AAATGC/TATCGG 1 -- ds50010--------
    rs1860155431,2
    --70413074(+) GATACC/TTGGAG 1 -- ds50010--------
    rs1476716871,2
    --70413146(+) GAATCC/TTCTCC 1 -- ds50010--------
    rs1407494311,2
    --70413180(+) ACTCAA/GGAGGC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ST3GAL2 (70413338 - 70473140 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ST3GAL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833272CNV Loss17160897
    nsv7285OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ST3GAL2
    DNA2.0 Custom Variant and Variant Library Synthesis for ST3GAL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607188    OMIM disorders: --

    8 diseases for ST3GAL2:    
    About MalaCards
    kidney fibrosarcoma    fibrosarcoma    morquio syndrome b    sly syndrome
    mucopolysaccharidoses    colorectal cancer    hiv-1    breast cancer


    ST3GAL2 for disorders           About GeneDecksing


    Export disorders for ST3GAL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ST3GAL2 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with ST3GAL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of cDNA for a human Gal(beta1-3)GalNAc alpha2,3-sialyltransferase from the CEM T-cell line. (PubMed id 9266697)1, 2, 3 Giordanengo V. and Lefebvre J.-C. (Eur. J. Biochem. 1997)
    2. Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialyltransferase (hST3Gal II). (PubMed id 8920913)1, 2, 3 Kim Y.-J.... Lee Y.-C. (Biochem. Biophys. Res. Commun. 1996)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase. (PubMed id 12716912)1, 9 Saito S....Miyagi T. (J. Biol. Chem. 2003)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    6. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Genomic structure, expression, and transcriptional regulation of human Gal beta 1,3 GalNAc alpha 2,3-sialyltransferase gene. (PubMed id 12504121)1 Taniguchi A....Matsumoto K. (Biochem. Biophys. Res. Commun. 2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Three genes that encode human beta-galactoside alpha 2,3- sialyltransferases. Structural analysis and chromosomal mapping studies. (PubMed id 7655169)1 Chang M.-L.... Lau J.T.Y. (Glycobiology 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6483 HGNC: 10863 AceView: SIAT4B Ensembl:ENSG00000157350 euGenes: HUgn6483
    ECgene: ST3GAL2 Kegg: 6483 H-InvDB: ST3GAL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ST3GAL2 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST3GAL2
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_623

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ST3GAL2 gene:
    Search GeneIP for patents involving ST3GAL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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