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Aliases for ST3GAL2 Gene

Aliases for ST3GAL2 Gene

  • ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2 2 3 5
  • Sialyltransferase 4B (Beta-Galactosidase Alpha-2,3-Sialytransferase) 2 3
  • Gal-Beta-1,3-GalNAc-Alpha-2,3-Sialyltransferase 3 4
  • Beta-Galactoside Alpha-2,3-Sialyltransferase 2 3 4
  • Alpha 2,3-ST 2 3 4
  • EC 4 63
  • Gal-NAc6S 3 4
  • ST3Gal II 3 4
  • ST3GalA.2 3 4
  • ST3GALII 3 4
  • SIAT4-B 3 4
  • SIAT4B 3 4
  • Beta-Galactoside Alpha-2,3-Sialytransferase 3
  • Sialyltransferase 4B 4
  • EC 63

External Ids for ST3GAL2 Gene

Previous HGNC Symbols for ST3GAL2 Gene

  • SIAT4B

Previous GeneCards Identifiers for ST3GAL2 Gene

  • GC16M068972
  • GC16M056246

Summaries for ST3GAL2 Gene

Entrez Gene Summary for ST3GAL2 Gene

  • The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4A. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST3GAL2 Gene

ST3GAL2 (ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2) is a Protein Coding gene. Diseases associated with ST3GAL2 include Epileptic Encephalopathy, Early Infantile, 15 and Kidney Fibrosarcoma. Among its related pathways are Glycosaminoglycan metabolism and Glycosphingolipid biosynthesis - ganglio series. GO annotations related to this gene include sialyltransferase activity and beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. An important paralog of this gene is ST3GAL4.

UniProtKB/Swiss-Prot for ST3GAL2 Gene

  • It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST3GAL2 Gene

Genomics for ST3GAL2 Gene

Regulatory Elements for ST3GAL2 Gene

Enhancers for ST3GAL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ST3GAL2 on UCSC Golden Path with GeneCards custom track

Promoters for ST3GAL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ST3GAL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ST3GAL2 Gene

70,375,978 bp from pter
70,439,237 bp from pter
63,260 bases
Minus strand

Genomic View for ST3GAL2 Gene

Genes around ST3GAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST3GAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST3GAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST3GAL2 Gene

Proteins for ST3GAL2 Gene

  • Protein details for ST3GAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
    Protein Accession:
    Secondary Accessions:
    • O00654

    Protein attributes for ST3GAL2 Gene

    350 amino acids
    Molecular mass:
    40173 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST3GAL2 Gene

Proteomics data for ST3GAL2 Gene at MOPED

Selected DME Specific Peptides for ST3GAL2 Gene

Post-translational modifications for ST3GAL2 Gene

  • The soluble form derives from the membrane form by proteolytic processing.
  • Glycosylation at Asn 92 and Asn 211
  • Modification sites at PhosphoSitePlus

Other Protein References for ST3GAL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ST3GAL2 ("ST3 beta-Gal alpha-2,3-Sialyltransferase 2/ST3GAL2")

Domains & Families for ST3GAL2 Gene

Gene Families for ST3GAL2 Gene

Protein Domains for ST3GAL2 Gene

Suggested Antigen Peptide Sequences for ST3GAL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 29 family.
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST3GAL2: view

Function for ST3GAL2 Gene

Molecular function for ST3GAL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R.
UniProtKB/Swiss-Prot Function:
It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.

Enzyme Numbers (IUBMB) for ST3GAL2 Gene

genes like me logo Genes that share phenotypes with ST3GAL2: view

Animal Models for ST3GAL2 Gene

MGI Knock Outs for ST3GAL2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ST3GAL2

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ST3GAL2 Gene

Localization for ST3GAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST3GAL2 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for ST3GAL2 Gene COMPARTMENTS Subcellular localization image for ST3GAL2 gene
Compartment Confidence
golgi apparatus 5
extracellular 4
endoplasmic reticulum 1
lysosome 1
peroxisome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for ST3GAL2 Gene

Pathways & Interactions for ST3GAL2 Gene

genes like me logo Genes that share pathways with ST3GAL2: view

UniProtKB/Swiss-Prot Q16842-SIA4B_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for ST3GAL2 Gene

Gene Ontology (GO) - Biological Process for ST3GAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001574 ganglioside biosynthetic process IBA --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006464 cellular protein modification process TAS 9266697
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006493 protein O-linked glycosylation TAS --
genes like me logo Genes that share ontologies with ST3GAL2: view

No data available for SIGNOR curated interactions for ST3GAL2 Gene

Drugs & Compounds for ST3GAL2 Gene

(2) Additional Compounds for ST3GAL2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytidine monophosphate
  • 5'-CMP
  • 5-Cytidylate
  • 5-Cytidylic acid
  • CMP
  • Cytidine 5'-monophosphate
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-Acetylneuraminate
  • CMP-N-Acylneuraminate
  • CMP-NeuNAc
  • Cytidine 5'-monophosphate N-acetylneuraminic acid
  • Cytidine Monophosphate N-Acetylneuraminate
genes like me logo Genes that share compounds with ST3GAL2: view

Transcripts for ST3GAL2 Gene

Unigene Clusters for ST3GAL2 Gene

ST3 beta-galactoside alpha-2,3-sialyltransferase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP3: - -
SP4: - -

Relevant External Links for ST3GAL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ST3GAL2 Gene

mRNA expression in normal human tissues for ST3GAL2 Gene

mRNA differential expression in normal tissues according to GTEx for ST3GAL2 Gene

This gene is overexpressed in Whole Blood (x7.5).

Protein differential expression in normal tissues from HIPED for ST3GAL2 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ST3GAL2 Gene

SOURCE GeneReport for Unigene cluster for ST3GAL2 Gene Hs.368611

mRNA Expression by UniProt/SwissProt for ST3GAL2 Gene

Tissue specificity: Highly expressed in skeletal muscle and heart and to a much lesser extent in brain, placenta, liver and pancreas. Scarcely detectable in lung and kidney.
genes like me logo Genes that share expression patterns with ST3GAL2: view

Protein tissue co-expression partners for ST3GAL2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ST3GAL2 Gene

Orthologs for ST3GAL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST3GAL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ST3GAL2 35
  • 92.48 (n)
  • 96 (a)
  • 96 (a)
(Canis familiaris)
Mammalia ST3GAL2 35
  • 91.9 (n)
  • 97.71 (a)
ST3GAL2 36
  • 98 (a)
(Mus musculus)
Mammalia St3gal2 35
  • 89.24 (n)
  • 94.29 (a)
St3gal2 16
St3gal2 36
  • 94 (a)
(Pan troglodytes)
Mammalia ST3GAL2 35
  • 98.95 (n)
  • 99.14 (a)
ST3GAL2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia St3gal2 35
  • 88.1 (n)
  • 94 (a)
(Monodelphis domestica)
Mammalia ST3GAL2 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia ST3GAL2 36
  • 88 (a)
(Gallus gallus)
Aves ST3GAL2 35
  • 82.71 (n)
  • 86.46 (a)
ST3GAL2 36
  • 87 (a)
(Anolis carolinensis)
Reptilia ST3GAL2 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia st3Gal-II 35
st3gal2 35
  • 69.53 (n)
  • 75.93 (a)
African clawed frog
(Xenopus laevis)
Amphibia st3Gal-II 35
(Danio rerio)
Actinopterygii st3gal2 35
  • 71.06 (n)
  • 71.63 (a)
wufd05f03 35
st3gal2 36
  • 63 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7280 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4378 36
  • 38 (a)
Species with no ortholog for ST3GAL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST3GAL2 Gene

Gene Tree for ST3GAL2 (if available)
Gene Tree for ST3GAL2 (if available)

Paralogs for ST3GAL2 Gene

(1) SIMAP similar genes for ST3GAL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ST3GAL2: view

Variants for ST3GAL2 Gene

Sequence variations from dbSNP and Humsavar for ST3GAL2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs15596 -- 70,379,568(+) AATTA(C/T)TATTG utr-variant-3-prime
rs8062183 -- 70,440,031(+) ttttt(A/G)gtgtg upstream-variant-2KB
rs12935225 -- 70,402,133(+) catct(C/T)tacta intron-variant
rs4548852 -- 70,436,179(+) tccca(A/G)cactt intron-variant
rs9921538 -- 70,440,902(+) cgcca(C/T)tgcac upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ST3GAL2 Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
nsv833272 CNV Loss 17160897

Variation tolerance for ST3GAL2 Gene

Residual Variation Intolerance Score: 10.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ST3GAL2 Gene

Disorders for ST3GAL2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ST3GAL2 Gene - From: OMIM and DISEASES

Disorder Aliases PubMed IDs
epileptic encephalopathy, early infantile, 15
  • eiee15
kidney fibrosarcoma
  • fibrosarcoma of the kidney
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ST3GAL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ST3GAL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST3GAL2 Gene

Publications for ST3GAL2 Gene

  1. Cloning and expression of cDNA for a human Gal(beta1-3)GalNAc alpha2,3-sialyltransferase from the CEM T-cell line. (PMID: 9266697) Giordanengo V. … Lefebvre J.-C. (Eur. J. Biochem. 1997) 2 3 4 67
  2. Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase. (PMID: 12716912) Saito S. … Miyagi T. (J. Biol. Chem. 2003) 3 23
  3. Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialyltransferase (hST3Gal II). (PMID: 8920913) Kim Y.-J. … Lee Y.-C. (Biochem. Biophys. Res. Commun. 1996) 2 3
  4. Critical role of evolutionarily conserved glycosylation at Asn211 in the intracellular trafficking and activity of sialyltransferase ST3Gal-II. (PMID: 25916169) Ruggiero F.M. … Daniotti J.L. (Biochem. J. 2015) 3
  5. Interferon-inducible factor 16 is a novel modulator of glucocorticoid action. (PMID: 20086048) Berry A. … Donn R.P. (FASEB J. 2010) 23

Products for ST3GAL2 Gene

Sources for ST3GAL2 Gene