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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ST3GAL2 Gene

protein-coding   GIFtS: 57
GCID: GC16M070413

ST3 beta-galactoside alpha-2,3-sialyltransferase 2

(Previous name: sialyltransferase 4B (beta-galactosidase alpha-2,3-sialytransferase)...)
(Previous symbol: SIAT4B)
 Explore 5 diseases affiliated with
ST3GAL2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ST3GAL2    

Aliases
for ST3GAL2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 21 2     SIAT4-B2 3
SIAT4B1 2 3     ST3Gal II2 3
ST3GalA.21 2 3     EC 2.4.99.43 8
ST3GALII1 2     Beta-Galactoside Alpha-2,3-Sialytransferase2
Sialyltransferase 4B (Beta-Galactosidase Alpha-2,3-Sialytransferase)1 2     CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,3-Sialyltransferase 22
Alpha 2,3-ST 22 3     ST3GalII3
Beta-Galactoside Alpha-2,3-Sialyltransferase 22 3     Sialyltransferase 4B3
Gal-NAc6S2 3     EC 2.4.99.78
Gal-Beta-1,3-GalNAc-Alpha-2,3-Sialyltransferase1     

External Ids:    HGNC: 108631   Entrez Gene: 64832   Ensembl: ENSG000001573507   OMIM: 6071885   UniProtKB: Q168423   

Export aliases for ST3GAL2 gene to outside databases

Previous GC identifers: GC16M068972 GC16M056246


Summaries
for ST3GAL2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ST3GAL2:
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from
CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be
proteolytically processed to a soluble form. This protein, which is a member of glycosyltransferase family 29, can use
the same acceptor substrates as does sialyltransferase 4A. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SIA4B_HUMAN, Q16842
Function: It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in
terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate
the same acceptor substrates but exhibit different Km values




Genomic Views
for ST3GAL2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ST3GAL2 gene promoter:
         MAZR   FOXF2   p53   Olf-1   IRF-1   CUTL1   C/EBPalpha   PPAR-alpha   HOXA5   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ST3GAL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST3GAL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.3

ST3GAL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST3GAL2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M070413:  view genomic region     (about GC identifiers)

Start:
 70,413,338 bp from pter      End:
 70,473,140 bp from pter
Size:
 59,803 bases      Orientation:
 minus strand

Proteins
for ST3GAL2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SIA4B_HUMAN, Q16842 (See protein sequence)
Recommended Name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2  
Size: 350 amino acids; 40173 Da
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (By similarity).
Secreted (By similarity). Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid (By
similarity)
Secondary accessions: O00654

Explore the universe of human proteins at neXtProt for ST3GAL2: NX_Q16842

Post-translational modifications:

  • The soluble form derives from the membrane form by proteolytic processing (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16842

    • 4/7 DME Specific Peptides for ST3GAL2 (Q16842) (see all 7)
     YGFGADS  WHHYWENN  HGRYPSTG  DVGSRTTHH 

    ST3GAL2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_008858.1  
    ENSEMBL proteins: 
     ENSP00000377257   ENSP00000345477  
    Reactome Protein details: Q16842
    Human Recombinant Protein Products: 
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    Novus Biologicals ST3GAL2 Proteins
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ST3GAL2

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0030173integral to Golgi membrane IEA--


    ST3GAL2 for ontologies           About GeneDecksing



    ST3GAL2 Antibody Products: 
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    Uscn ELISAs and CLIAs for ST3GAL2

    Protein Domains /
    Families
    for ST3GAL2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ST3GAL2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001675 Glyco_trans_29
     IPR012163 Sialyl_trans

    Graphical View of Domain Structure for InterPro Entry Q16842

    ProtoNet protein and cluster: Q16842

    1 Blocks protein family: IPB001675 Glycosyl transferase

    UniProtKB/Swiss-Prot: SIA4B_HUMAN, Q16842
    Similarity: Belongs to the glycosyltransferase 29 family


    Function
    for ST3GAL2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SIA4B_HUMAN, Q16842
    Function: It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in
    terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate
    the same acceptor substrates but exhibit different Km values
    Catalytic activity: CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP +
    alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R

    Enzyme Numbers (IUBMB): EC 2.4.99.41 2 EC 2.4.99.72

    miRNA
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    hsa-miR-3678-3p hsa-miR-429 hsa-miR-513a-5p hsa-miR-25 hsa-miR-765 hsa-miR-877* hsa-miR-9 hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmid: ST3GAL2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003836beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IEA--
    GO:0008373sialyltransferase activity ----


    ST3GAL2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out St3gal2tm1Jxm for ST3GAL2
         2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for St3gal2):
     hematopoietic system  normal 

    ST3GAL2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ST3GAL2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MPS IIIC - Sanfilippo syndrome C
    8/14 pathways (see all 14)
    		MPS IIIC - Sanfilippo syndrome C1.00
    		MPS IIIA - Sanfilippo syndrome A1.00
    		MPS I - Hurler syndrome1.00
    		MPS IIID - Sanfilippo syndrome D1.00
    		Mucopolysaccharidoses1.00
    		MPS IX - Natowicz syndrome1.00
    		MPS IV - Morquio syndrome A1.00
    		MPS II - Hunter syndrome1.00
    2Keratan sulfate biosynthesis
    		Keratan sulfate biosynthesis1.00
    		Glycosaminoglycan biosynthesis - keratan sulfate0.45
    		Keratan sulfate/keratin metabolism0.84
    3Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein
    		Termination of O-glycan biosynthesis0.69
    		Mucin type O-Glycan biosynthesis0.00
    		O-linked glycosylation of mucins0.28
    4Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    5Ganglio Sphingolipid Metabolism
    		Ganglio Sphingolipid Metabolism1.00
    		Glycosphingolipid biosynthesis - ganglio series0.53

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for ST3GAL2 
        Ganglio Sphingolipid Metabolism

    5/22        Reactome Pathways for ST3GAL2 (see all 22)
        MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    Keratan sulfate/keratin metabolism
    MPS II - Hunter syndrome


    5         Kegg Pathways  (Kegg details for ST3GAL2):
        Mucin type O-Glycan biosynthesis
    Glycosaminoglycan biosynthesis - keratan sulfate
    Glycosphingolipid biosynthesis - globo series
    Glycosphingolipid biosynthesis - ganglio series
    Metabolic pathways

    UniProtKB/Swiss-Prot: SIA4B_HUMAN, Q16842
    Pathway: Protein modification; protein glycosylation


    ST3GAL2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ST3GAL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/46 Interacting proteins for ST3GAL2 (Q168422, 3 ENSP000003454774) via UniProtKB, MINT, STRING, and/or I2D (see all 46)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENO2P091042, 3MINT-63434 I2D: score=4 
    B3GALT5ENSP000003433184STRING: ENSP00000343318
    C1GALT1ENSP000002231224STRING: ENSP00000223122
    FUT1ENSP000003120214STRING: ENSP00000312021
    FUT2ENSP000003757484STRING: ENSP00000375748
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006040amino sugar metabolic process TAS9266697
    GO:0006464cellular protein modification process TAS9266697
    GO:0006486protein glycosylation ----
    GO:0016266O-glycan processing TAS--


    ST3GAL2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ST3GAL2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ST3GAL2
    Search CenterWatch for drugs/clinical trials and news about ST3GAL2 / SIA4B 

    Transcripts
    for ST3GAL2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ST3GAL2 gene: 
    NM_006927.3  

    Unigene Cluster for ST3GAL2:

    ST3 beta-galactoside alpha-2,3-sialyltransferase 2
    Hs.368611  [show with all ESTs]
    Unigene Representative Sequence: AK127322
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393640(uc002eyw.2) ENST00000567822 ENST00000566097 ENST00000561708
    ENST00000567586 ENST00000342907(uc002eyx.2)

    miRNA
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    hsa-miR-3678-3p hsa-miR-429 hsa-miR-513a-5p hsa-miR-25 hsa-miR-765 hsa-miR-877* hsa-miR-9 hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmid: ST3GAL2 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF086257.1 AK127322.1 AK313020.1 BC036777.1 BC064480.1 U63090.1 X96667.1 

    9 DOTS entries:

    DT.99989994  DT.310837  DT.100715956  DT.100751685  DT.407132  DT.120687421  DT.120687458  DT.95342472 
    DT.100751686 

    24/143 AceView cDNA sequences (see all 143):

    AL134178 AA564366 AW043871 AF086257 AA679819 AI207788 BF058186 BU657735 
    AI962559 AI382279 AI383394 BM920376 AW007025 BE207698 BU158526 CD674963 
    BQ898848 AA709312 BX340808 BX099248 NM_006927 BC064480 BF432594 BU074422 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                                  -                                             
    SP2:                                                                                                
    SP3:        -           -                                                                           
    SP4:              -     -                                                                           
    SP5:                                                                                                


    ECgene alternative splicing isoforms for ST3GAL2

    Expression
    for ST3GAL2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ST3GAL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATCCCGCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ST3GAL2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ST3GAL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ST3GAL2

    SOURCE GeneReport for Unigene cluster: Hs.368611

    UniProtKB/Swiss-Prot: SIA4B_HUMAN, Q16842
    Tissue specificity: Highly expressed in skeletal muscle and heart and to a much lesser extent in brain, placenta, liver
    and pancreas. Scarcely detectable in lung and kidney

        SABiosciences Expression via Pathway-Focused PCR Array including ST3GAL2: 
              Glycosylation in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for ST3GAL2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ST3GAL2 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ST3GAL21 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 82.71(n)
    86.46(a)    		   395139  NM_204480.2  NP_989811.2 
    lizard
    (Anolis carolinensis)    		 Reptilia ST3GAL26
    		 --
    		 81(a)
    		 1 ↔ 1
    		 GL343539.1(1605-7874)
    African clawed frog
    (Xenopus laevis)    		 Amphibia st3Gal-II2 alpha2,3-sialyltransferase 73.08(n)    AJ585762.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufd05f032 Transcribed sequence with weak similarity to protein more 74.32(n)    57054817 


    ENSEMBL Gene Tree for ST3GAL2 (if available)
    TreeFam Gene Tree for ST3GAL2 (if available) 

    Paralogs
    for ST3GAL2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ST3GAL2 gene
    ST3GAL32  ST6GALNAC12  ST3GAL62  ST6GALNAC22  ST3GAL12  ST3GAL42  ST3GAL52  
    1 SIMAP similar gene for ST3GAL2 using alignment to 1 protein entry:     SIA4B_HUMAN:
    ST3GAL1

    ST3GAL2 for paralogs           About GeneDecksing



    Genomic Variants
    for ST3GAL2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/982 NCBI SNPs in ST3GAL2 are shown (see all 982)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1170253051,2
    		F,--70412862(+) GGCCAT/CTGCAC 1 -- ds50011Minor allele frequency- C:0.04EA 120
    rs1445792871,2
    		--70412935(+) TGCGGC/GTTGCC 1 -- ds50010--------
    rs1162960941,2
    		--70412945(+) CTGTGG/ACATGG 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1807530661,2
    		--70412964(+) GGGCTA/GTGGAG 1 -- ds50010--------
    rs1397715571,2
    		--70412995(+) AAAACC/GTGACT 1 -- ds50010--------
    rs771498521,2
    		F,--70413048(+) CCACCC/TAAATG 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1453356611,2
    		--70413054(+) AAATGC/TATCGG 1 -- ds50010--------
    rs1860155431,2
    		--70413074(+) GATACC/TTGGAG 1 -- ds50010--------
    rs1476716871,2
    		--70413146(+) GAATCC/TTCTCC 1 -- ds50010--------
    rs1407494311,2
    		--70413180(+) ACTCAA/GGAGGC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ST3GAL2 (70413338 - 70473140 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ST3GAL2
         1 CNV: 4965

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    Disorders / Diseases
    for ST3GAL2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ST3GAL2 for disorders           About GeneDecksing

    OMIM gene information: 607188    OMIM disorders: --

    5 diseases for ST3GAL2:    About MalaCards
    kidney fibrosarcoma    fibrosarcoma    colorectal cancer    breast cancer
    immunodeficiency


    Export disorders for ST3GAL2 gene to outside databases

    Publications
    for ST3GAL2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ST3GAL2 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with ST3GAL2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of cDNA for a human Gal(beta1-3)GalNAc alpha2,3-sialyltransferase from the CEM T-cell line. (PubMed id 9266697)1, 2, 3 Giordanengo V. and Lefebvre J.-C. (1997)
    2. Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialytransferase (hST3Gal II). (PubMed id 8920913)1, 2, 3 Kim Y.J....Lee Y.C. (1996)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase. (PubMed id 12716912)1, 9 Saito S....Miyagi T. (2003)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    6. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    8. Genomic structure, expression, and transcriptional regulation of human Gal beta 1,3 GalNAc alpha 2,3-sialyltransferase gene. (PubMed id 12504121)1 Taniguchi A....Matsumoto K. (2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Three genes that encode human beta-galactoside alpha 2,3- sialyltransferases. Structural analysis and chromosomal mapping studies. (PubMed id 7655169)1 Chang M.-L.... Lau J.T.Y. (1995)

    External Searches for ST3GAL2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing ST3GAL2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6483 HGNC: 10863 AceView: SIAT4B Ensembl:ENSG00000157350 euGenes: HUgn6483
    ECgene: ST3GAL2 Kegg: 6483 H-InvDB: ST3GAL2

    Other Databases showing ST3GAL2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ST3GAL2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ST3GAL2 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST3GAL2
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_623

    Intellectual Property
    for ST3GAL2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ST3GAL2 gene:
    Search GeneIP for patents involving ST3GAL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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