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ST3GAL2 Gene

protein-coding GIFtS: 60
GCID: GC16M070413

ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2

(Previous name: sialyltransferase 4B (beta-galactosidase alpha-2,3-sialytransferase))
(Previous symbol: SIAT4B)

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2¹ ²		ST3Gal II² ³
SIAT4B¹ ² ³		EC 2.4.99.4³ ⁸
Sialyltransferase 4B (Beta-Galactosidase Alpha-2,3-Sialytransferase)¹ ²		ST3GALII²
Alpha 2,3-ST 2² ³		Beta-Galactoside Alpha-2,3-Sialytransferase²
Beta-Galactoside Alpha-2,3-Sialyltransferase 2² ³		CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,3-Sialyltransferase 2²
Gal-NAc6S² ³		ST3GalII³
Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase² ³		Sialyltransferase 4B³
SIAT4-B² ³		EC 2.4.99.7⁸
ST3GalA.2² ³

External Ids:	HGNC: 10863¹	Entrez Gene: 6483²	Ensembl: ENSG00000157350⁷	OMIM: 607188⁵	UniProtKB: Q16842³

ORGUL members:

Export aliases for ST3GAL2 gene to outside databases

Previous GC identifers: GC16M068972 GC16M056246

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ST3GAL2 Gene:

The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from

CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be

proteolytically processed to a soluble form. This protein, which is a member of glycosyltransferase family 29,

can use the same acceptor substrates as does sialyltransferase 4A. (provided by RefSeq, Jul 2008)

GeneCards Summary for ST3GAL2 Gene:

ST3GAL2 (ST3 beta-galactoside alpha-2,3-sialyltransferase 2) is a protein-coding gene. Diseases associated with ST3GAL2 include kidney fibrosarcoma, and fibrosarcoma. GO annotations related to this gene include beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. An important paralog of this gene is ST3GAL3.

UniProtKB/Swiss-Prot: SIA4B_HUMAN, Q16842

Function: It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in

terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B

sialylate the same acceptor substrates but exhibit different Km values

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000016.10 NC_018927.2 NT_010498.16

Regulatory elements:

Regulatory transcription factor binding sites in the ST3GAL2 gene promoter:
MAZR FOXF2 p53 Olf-1 IRF-1 CUTL1 C/EBPalpha PPAR-alpha HOXA5 Pax-4a
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search Chromatin IP Primers for ST3GAL2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST3GAL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.3

ST3GAL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST3GAL2 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M070413: view genomic region (about GC identifiers)

Start:	70,413,338 bp from pter	End:	70,473,140 bp from pter
Size:	59,803 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SIA4B_HUMAN, Q16842 (See protein sequence)

Recommended Name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2

Size: 350 amino acids; 40173 Da

Secondary accessions: O00654

Explore the universe of human proteins at neXtProt for ST3GAL2: NX_Q16842

Explore proteomics data for ST3GAL2 at MOPED

Post-translational modifications:

The soluble form derives from the membrane form by proteolytic processing (By similarity)¹

Glycosylation² at Asn211

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for ST3GAL2 (Q16842) (see all 7)

YGFGADS

WHHYWENN

HGRYPSTG

DVGSRTTHH

See ST3GAL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_008858.1

ENSEMBL proteins:

ENSP00000377257 ENSP00000345477

Reactome Protein details: Q16842

ST3GAL2 Human Recombinant Protein Products:

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	Browse Proteins at Cloud-Clone Corp.

ST3GAL2 Antibody Products:

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	Novus Biologicals ST3GAL2 Antibodies
	Abcam antibodies for ST3GAL2
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ST3GAL2 Assay Products:

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	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

ST3G: Sialyltransferases

2 InterPro protein domains:

IPR001675 Glyco_trans_29

IPR012163 Sialyl_trans

Graphical View of Domain Structure for InterPro Entry Q16842

ProtoNet protein and cluster: Q16842

1 Blocks protein domain: IPB001675 Glycosyl transferase

UniProtKB/Swiss-Prot: SIA4B_HUMAN, Q16842

Similarity: Belongs to the glycosyltransferase 29 family

ST3GAL2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: SIA4B_HUMAN, Q16842

Function: It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in

terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B

sialylate the same acceptor substrates but exhibit different Km values

Catalytic activity: CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP +

alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R

Enzyme Numbers (IUBMB): EC 2.4.99.4¹ ² EC 2.4.99.7²

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	IEA	--
GO:0008373	sialyltransferase activity	--	--

ST3GAL2 for ontologies About GeneDecksing

Phenotypes:
2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for St3gal2):

hematopoietic system

normal

ST3GAL2 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out St3gal2^tm1Jxm for ST3GAL2

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ST3GAL2

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miRNA Products:		miRTarBase miRNAs that target ST3GAL2: hsa-mir-615-3p (MIRT039844), hsa-mir-324-3p (MIRT042983), hsa-mir-484 (MIRT042249), hsa-mir-760 (MIRT036742)

		Block miRNA regulation of human, mouse, rat ST3GAL2 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate ST3GAL2 (see all 50):
		hsa-miR-3678-3p hsa-miR-429 hsa-miR-513a-5p hsa-miR-25 hsa-miR-765 hsa-miR-877* hsa-miR-9 hsa-miR-1184

		SwitchGear 3'UTR luciferase reporter plasmid: ST3GAL2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ST3GAL2
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST3GAL2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

SIA4B_HUMAN, Q16842: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (By similarity).

Secreted (By similarity). Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid (By

similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
golgi apparatus	5
cytosol	3
extracellular	2
endoplasmic reticulum	1
lysosome	1
peroxisome	1
plasma membrane	1

About this image

Gene Ontology (GO): Selected cellular component terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	--
GO:0005576	extracellular region	IEA	--
GO:0005737	cytoplasm	--	--
GO:0005794	Golgi apparatus	--	--
GO:0030173	integral component of Golgi membrane	IEA	--

ST3GAL2 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ST3GAL2 About (see all 8)

See pathways by source

SuperPath

Selected contained pathways About (see all per SuperPath)

Keratan sulfate/keratin metabolism

	Keratan sulfate/keratin metabolism	0.85			Glycosaminoglycan biosynthesis - keratan sulfate	0.43
	Keratan sulfate biosynthesis	0.85

O-linked glycosylation of mucins

	O-linked glycosylation of mucins	0.47			Termination of O-glycan biosynthesis	0.38
	Mucin type O-Glycan biosynthesis	0.47

Glycosphingolipid biosynthesis - ganglio series

Ganglio Sphingolipid Metabolism

0.53

Glycosphingolipid biosynthesis - ganglio series

0.53

Metabolism

Metabolism

0.38

Metabolic pathways

0.38

MPS VI - Maroteaux-Lamy syndrome

MPS VI - Maroteaux-Lamy syndrome	0.45	MPS IIIB - Sanfilippo syndrome B	0.45
MPS IIIC - Sanfilippo syndrome C	0.45	MPS II - Hunter syndrome	0.45
MPS IV - Morquio syndrome A	0.45	Glycosaminoglycan metabolism	0.45
Mucopolysaccharidoses	0.45	MPS IV - Morquio syndrome B	0.45

Pathways by source See SuperPaths
Show all pathways

1 BioSystems Pathway for ST3GAL2

Ganglio Sphingolipid Metabolism

3 Reactome Pathways for ST3GAL2

	Sialic acid metabolism
	Keratan sulfate biosynthesis
	Termination of O-glycan biosynthesis

5 Kegg Pathways (Kegg details for ST3GAL2):

	Mucin type O-Glycan biosynthesis
	Glycosaminoglycan biosynthesis - keratan sulfate
	Glycosphingolipid biosynthesis - globo series
	Glycosphingolipid biosynthesis - ganglio series
	Metabolic pathways

UniProtKB/Swiss-Prot: SIA4B_HUMAN, Q16842

Pathway: Protein modification; protein glycosylation

ST3GAL2 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Array including ST3GAL2:

Glycosylation in human mouse rat

Interactions:

Search GeneGlobe Interaction Network for ST3GAL2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for ST3GAL2 (Q16842^{2, 3} ENSP00000345477⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 46)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENO2	P09104²^,³	MINT-63434 I2D: score=4
B3GALT5	ENSP00000343318⁴	STRING: ENSP00000343318
C1GALT1	ENSP00000223122⁴	STRING: ENSP00000223122
ENSG00000236802	ENSP00000414880⁴	STRING: ENSP00000414880
FUT1	ENSP00000312021⁴	STRING: ENSP00000312021

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Gene Ontology (GO): Selected biological process terms (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006040	amino sugar metabolic process	TAS	9266697
GO:0006464	cellular protein modification process	TAS	9266697
GO:0006486	protein glycosylation	--	--
GO:0016266	O-glycan processing	TAS	--

ST3GAL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for ST3GAL2 (SIA4B)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ST3GAL2 gene:

NM_006927.3

Unigene Cluster for ST3GAL2:

ST3 beta-galactoside alpha-2,3-sialyltransferase 2

Hs.368611 [show with all ESTs]

Unigene Representative Sequence: AK127322

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000393640(uc002eyw.2) ENST00000567822 ENST00000566097 ENST00000561708

ENST00000567586 ENST00000342907(uc002eyx.2)

miRNA Products:		Block miRNA regulation of human, mouse, rat ST3GAL2 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate ST3GAL2 (see all 50):
		hsa-miR-3678-3p hsa-miR-429 hsa-miR-513a-5p hsa-miR-25 hsa-miR-765 hsa-miR-877* hsa-miR-9 hsa-miR-1184

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		QuantiFast Probe-based Assays in human, mouse, rat ST3GAL2

Additional mRNA sequence:

AF086257.1 AK127322.1 AK313020.1 BC036777.1 BC064480.1 U63090.1 X96667.1

9 DOTS entries:

DT.99989994 DT.310837 DT.100715956 DT.100751685 DT.407132 DT.120687421 DT.120687458 DT.95342472

DT.100751686

Selected AceView cDNA sequences (see all 143):

AI962559 AA564366 AL134178 BX099248 BU074422 AI097613 CD674963 AW027254

BQ898848 AW043871 AI382279 AW007025 BU657735 AK127322 BF058186 AU142783

AA709312 BM699410 AI383394 NM_006927 CD675612 AF086257 BM920376 BU158526

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL2 About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	·	4d	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b
SP1:																	-
SP2:
SP3:			-				-
SP4:					-		-
SP5:

ECgene alternative splicing isoforms for ST3GAL2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ST3GAL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AATCCCGCCA

About this image

ST3GAL2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ST3GAL2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.368611

UniProtKB/Swiss-Prot: SIA4B_HUMAN, Q16842

Tissue specificity: Highly expressed in skeletal muscle and heart and to a much lesser extent in brain, placenta,

liver and pancreas. Scarcely detectable in lung and kidney

Pathway & Disease-focused RT² Profiler PCR Array including ST3GAL2:

Glycosylation in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for ST3GAL2 OriGene qSTAR qPCR primer pairs in human, mouse for ST3GAL2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat ST3GAL2
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		QuantiFast Probe-based Assays in human, mouse, rat ST3GAL2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST3GAL2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ST3GAL2 gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	St3gal2^{1 , 5}	ST3 beta-galactoside alpha-2,3-sialyltransferase 2^{1, 5}	89.24(n)¹ 94.29(a)¹		8 (57.81 cM)⁵ 20444¹ NM_009179.3¹ NP_033205.2¹ 110919922⁵
chicken (Gallus gallus)	Aves	ST3GAL2¹	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	82.71(n) 86.46(a)		395139 NM_204480.2 NP_989811.2
lizard (Anolis carolinensis)	Reptilia	ST3GAL2⁶	ST3 beta-galactoside alpha-2,3-sialyltransferase 2...	76(a)	1 ↔ 1	GL343539.1(323-8855)
African clawed frog (Xenopus laevis)	Amphibia	st3Gal-II²	alpha2,3-sialyltransferase	73.08(n)		AJ585762.1
zebrafish (Danio rerio)	Actinopterygii	wufd05f03²	Transcribed sequence with weak similarity to protein more	74.32(n)		57054817

ENSEMBL Gene Tree for ST3GAL2 (if available)
TreeFam Gene Tree for ST3GAL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ST3GAL2 gene

ST3GAL3² ST6GALNAC1² ST3GAL6² ST6GALNAC2² ST3GAL1² ST3GAL4² ST3GAL5²

1 SIMAP similar gene for ST3GAL2 using alignment to 1 protein entry: SIA4B_HUMAN:

ST3GAL1

ST3GAL2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs117025305^1,2	C,F	--	70412862(+)	`GGCCAT/CTGCAC`	1	--	ds500¹		1		EA	120
rs144579287^1,2		--	70412935(+)	`TGCGGC/GTTGCC`	1	--	ds500¹		0	--	--	--	--
rs116296094^1,2	F	--	70412945(+)	`CTGTGG/ACATGG`	1	--	ds500¹		1		WA	118
rs180753066^1,2		--	70412964(+)	`GGGCTA/GTGGAG`	1	--	ds500¹		0	--	--	--	--
rs139771557^1,2		--	70412995(+)	`AAAACC/GTGACT`	1	--	ds500¹		0	--	--	--	--
rs77149852^1,2	C,F	--	70413048(+)	`CCACCC/TAAATG`	1	--	ds500¹		1		WA	118
rs145335661^1,2		--	70413054(+)	`AAATGC/TATCGG`	1	--	ds500¹		0	--	--	--	--
rs186015543^1,2		--	70413074(+)	`GATACC/TTGGAG`	1	--	ds500¹		0	--	--	--	--
rs147671687^1,2		--	70413146(+)	`GAATCC/TTCTCC`	1	--	ds500¹		0	--	--	--	--
rs140749431^1,2		--	70413180(+)	`ACTCAA/GGAGGC`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ST3GAL2 (70413338 - 70473140 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for ST3GAL2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv833272	CNV	Loss	17160897
nsv7285	OTHER	Inversion	18451855

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607188 OMIM disorders: --

8 diseases for ST3GAL2:
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kidney fibrosarcoma fibrosarcoma morquio syndrome b sly syndrome

mucopolysaccharidoses colorectal cancer hiv-1 breast cancer

ST3GAL2 for disorders About GeneDecksing

Export disorders for ST3GAL2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ST3GAL2 gene, integrated from 10 sources (see all 20):
(articles sorted by number of sources associating them with ST3GAL2)

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Cloning and expression of cDNA for a human Gal(beta1-3)GalNAc alpha2,3-sialyltransferase from the CEM T-cell line. (PubMed id 9266697)^{1, 2, 3} Giordanengo V. and Lefebvre J.-C. (Eur. J. Biochem. 1997)
Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialyltransferase (hST3Gal II). (PubMed id 8920913)^{1, 2, 3} Kim Y.-J.... Lee Y.-C. (Biochem. Biophys. Res. Commun. 1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase. (PubMed id 12716912)^{1, 9} Saito S....Miyagi T. (J. Biol. Chem. 2003)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (amp 2008)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (Cell 2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (Nat. Genet. 2004)
Genomic structure, expression, and transcriptional regulation of human Gal beta 1,3 GalNAc alpha 2,3-sialyltransferase gene. (PubMed id 12504121)¹ Taniguchi A....Matsumoto K. (Biochem. Biophys. Res. Commun. 2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
Three genes that encode human beta-galactoside alpha 2,3- sialyltransferases. Structural analysis and chromosomal mapping studies. (PubMed id 7655169)¹ Chang M.-L.... Lau J.T.Y. (Glycobiology 1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6483	HGNC: 10863	AceView: SIAT4B	Ensembl:ENSG00000157350	euGenes: HUgn6483
ECgene: ST3GAL2	Kegg: 6483	H-InvDB: ST3GAL2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ST3GAL2	Pharmacogenomics, SNPs, Pathways
GGDB	http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST3GAL2
Functional Glycomics Gateway - GTase	http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_623

Intellectual Property for ST3GAL2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ST3GAL2 gene:
Search GeneIP for patents involving ST3GAL2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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ST3GAL2 Gene

ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2

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ST3GAL2 Gene

ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2

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