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Aliases for ST3GAL2 Gene

Aliases for ST3GAL2 Gene

  • ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2 2 3
  • Sialyltransferase 4B (Beta-Galactosidase Alpha-2,3-Sialytransferase) 2 3
  • Gal-Beta-1,3-GalNAc-Alpha-2,3-Sialyltransferase 3 4
  • Beta-Galactoside Alpha-2,3-Sialyltransferase 2 3 4
  • Alpha 2,3-ST 2 3 4
  • EC 2.4.99.4 4 64
  • Gal-NAc6S 3 4
  • ST3Gal II 3 4
  • ST3GalA.2 3 4
  • ST3GALII 3 4
  • SIAT4-B 3 4
  • SIAT4B 3 4
  • CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,3-Sialyltransferase 2 3
  • Beta-Galactoside Alpha-2,3-Sialytransferase 3
  • Sialyltransferase 4B 4
  • EC 2.4.99.7 64

External Ids for ST3GAL2 Gene

Previous Symbols for ST3GAL2 Gene

  • SIAT4B

Summaries for ST3GAL2 Gene

Entrez Gene Summary for ST3GAL2 Gene

  • The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4A. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST3GAL2 Gene

ST3GAL2 (ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. An important paralog of this gene is ST3GAL4.

UniProtKB/Swiss-Prot for ST3GAL2 Gene

  • It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST3GAL2 Gene

Genomics for ST3GAL2 Gene

Genomic Location for ST3GAL2 Gene

Start:
70,375,978 bp from pter
End:
70,439,237 bp from pter
Size:
63,260 bases
Orientation:
Minus strand

Genomic View for ST3GAL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ST3GAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST3GAL2 Gene

Regulatory Elements for ST3GAL2 Gene

Proteins for ST3GAL2 Gene

  • Protein details for ST3GAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16842-SIA4B_HUMAN
    Recommended name:
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
    Protein Accession:
    Q16842
    Secondary Accessions:
    • O00654

    Protein attributes for ST3GAL2 Gene

    Size:
    350 amino acids
    Molecular mass:
    40173 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST3GAL2 Gene

Proteomics data for ST3GAL2 Gene at MOPED

Selected DME Specific Peptides for ST3GAL2 Gene

Post-translational modifications for ST3GAL2 Gene

  • The soluble form derives from the membrane form by proteolytic processing.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn211

Other Protein References for ST3GAL2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ST3GAL2 Gene

Gene Families for ST3GAL2 Gene

HGNC:
  • ST3G :Sialyltransferases

Protein Domains for ST3GAL2 Gene

UniProtKB/Swiss-Prot:

SIA4B_HUMAN
Family:
  • Belongs to the glycosyltransferase 29 family.:
    • Q16842
genes like me logo Genes that share domains with ST3GAL2: view

Function for ST3GAL2 Gene

Molecular function for ST3GAL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UniProtKB/Swiss-Prot Function: It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values

Enzyme Numbers (IUBMB) for ST3GAL2 Gene

Gene Ontology (GO) - Molecular Function for ST3GAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IEA --
GO:0008373 sialyltransferase activity --
genes like me logo Genes that share ontologies with ST3GAL2: view

Phenotypes for ST3GAL2 Gene

genes like me logo Genes that share phenotypes with ST3GAL2: view

Animal Models for ST3GAL2 Gene

MGI Knock Outs for ST3GAL2:

miRNA for ST3GAL2 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for ST3GAL2 Gene

Localization for ST3GAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST3GAL2 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST3GAL2 Gene COMPARTMENTS Subcellular localization image for ST3GAL2 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
extracellular 2
endoplasmic reticulum 1
lysosome 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ST3GAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region IEA --
GO:0030173 integral component of Golgi membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with ST3GAL2: view

Pathways for ST3GAL2 Gene

genes like me logo Genes that share pathways with ST3GAL2: view

UniProtKB/Swiss-Prot Q16842-SIA4B_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for ST3GAL2 Gene

Gene Ontology (GO) - Biological Process for ST3GAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006040 amino sugar metabolic process TAS 9266697
GO:0006464 cellular protein modification process TAS 9266697
GO:0006486 protein glycosylation --
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
genes like me logo Genes that share ontologies with ST3GAL2: view

Transcripts for ST3GAL2 Gene

mRNA/cDNA for ST3GAL2 Gene

Unigene Clusters for ST3GAL2 Gene

ST3 beta-galactoside alpha-2,3-sialyltransferase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2:
SP3: - -
SP4: - -
SP5:

Relevant External Links for ST3GAL2 Gene

GeneLoc Exon Structure for
ST3GAL2
ECgene alternative splicing isoforms for
ST3GAL2

Expression for ST3GAL2 Gene

mRNA expression in normal human tissues for ST3GAL2 Gene

mRNA differential expression in normal tissues according to GTEx for ST3GAL2 Gene

This gene is overexpressed in Whole Blood (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ST3GAL2 Gene

SOURCE GeneReport for Unigene cluster for ST3GAL2 Gene Hs.368611

mRNA Expression by UniProt/SwissProt for ST3GAL2 Gene

Q16842-SIA4B_HUMAN
Tissue specificity: Highly expressed in skeletal muscle and heart and to a much lesser extent in brain, placenta, liver and pancreas. Scarcely detectable in lung and kidney.
genes like me logo Genes that share expressions with ST3GAL2: view

Orthologs for ST3GAL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST3GAL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST3GAL2 36
  • 98.95 (n)
  • 99.14 (a)
ST3GAL2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SIAT4B 37
  • 96 (a)
OneToOne
ST3GAL2 36
  • 92.48 (n)
  • 96 (a)
dog
(Canis familiaris)
Mammalia ST3GAL2 36
  • 91.9 (n)
  • 97.71 (a)
ST3GAL2 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St3gal2 36
  • 89.24 (n)
  • 94.29 (a)
St3gal2 16
St3gal2 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ST3GAL2 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ST3GAL2 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia St3gal2 36
  • 88.1 (n)
  • 94 (a)
chicken
(Gallus gallus)
Aves ST3GAL2 36
  • 82.71 (n)
  • 86.46 (a)
ST3GAL2 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST3GAL2 37
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia st3Gal-II 36
tropical clawed frog
(Silurana tropicalis)
Amphibia st3Gal-II 36
st3gal2 36
  • 69.53 (n)
  • 75.93 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7280 36
zebrafish
(Danio rerio)
Actinopterygii st3gal2 36
  • 71.06 (n)
  • 71.63 (a)
st3gal2 37
  • 63 (a)
OneToOne
wufd05f03 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4378 37
  • 38 (a)
OneToMany
Species with no ortholog for ST3GAL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST3GAL2 Gene

ENSEMBL:
Gene Tree for ST3GAL2 (if available)
TreeFam:
Gene Tree for ST3GAL2 (if available)

Paralogs for ST3GAL2 Gene

Paralogs for ST3GAL2 Gene

Selected SIMAP similar genes for ST3GAL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ST3GAL2: view

Variants for ST3GAL2 Gene

Sequence variations from dbSNP and Humsavar for ST3GAL2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs15596 -- 70,379,568(+) AATTA(C/T)TATTG utr-variant-3-prime
rs775196 -- 70,405,954(-) cctcc(C/T)gagta intron-variant
rs891138 -- 70,425,555(-) AATTA(A/T)CAAAT intron-variant
rs936994 -- 70,408,505(-) GAAGC(A/G)GCCCA intron-variant
rs1048142 -- 70,398,627(-) CCTTT(A/G)CATGT utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ST3GAL2 Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
nsv833272 CNV Loss 17160897

Relevant External Links for ST3GAL2 Gene

HapMap Linkage Disequilibrium report
ST3GAL2

Disorders for ST3GAL2 Gene

No disorders were found for ST3GAL2 Gene.

No data available for UniProtKB/Swiss-Prot for ST3GAL2 Gene

Publications for ST3GAL2 Gene

  1. Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialyltransferase (hST3Gal II). (PMID: 8920913) Kim Y.-J. … Lee Y.-C. (Biochem. Biophys. Res. Commun. 1996) 2 3 4
  2. Cloning and expression of cDNA for a human Gal(beta1-3)GalNAc alpha2,3-sialyltransferase from the CEM T-cell line. (PMID: 9266697) Giordanengo V. … Lefebvre J.-C. (Eur. J. Biochem. 1997) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase. (PMID: 12716912) Saito S. … Miyagi T. (J. Biol. Chem. 2003) 3 23
  5. Prognostic value of tumoral sialyltransferase expression and circulating E-selectin concentrations in node-negative breast cancer patients. (PMID: 12841680) Hebbar M. … Peyrat J.P. (Int. J. Biol. Markers 2003) 23

Products for ST3GAL2 Gene

Sources for ST3GAL2 Gene

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