ST3GAL1 Gene
protein-coding GIFtS : 57
GCID: GC08 M134468
ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (Previous name: sialyltransferase 4A (beta-galactosidase alpha-2,3-sialytransferase)... ) (Previous symbol: SIAT4A )
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Aliasesfor ST3GAL1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 1 1 2 EC 2.4.99.43 8 SIAT4A1 2 3 ST3GalA2 SIATFL1 2 3 ST3GalIA2 ST3GalA.11 2 3 ST3GalIA,12 ST3O1 2 3 CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,3-Sialyltransferase 12 Sialyltransferase 4A (Beta-Galactosidase Alpha-2,3-Sialytransferase)1 2 Sialyltransferase 4A (Beta-Galactoside Alpha-2,3-Sialyltransferase)2 Alpha 2,3-ST 12 3 Sialyltransferase 4A (Beta-Galactoside Alpha-2,3-Sialytransferase)2 Beta-Galactoside Alpha-2,3-Sialyltransferase 12 3 SIAT43 Gal-NAc6S2 3 Sialyltransferase 4A3 Gal-Beta-1,3-GalNAc-Alpha-2,3-Sialyltransferase1 ST3Gal I3 SIAT4-A2 3 EC 2.4.998 ST3GalI2 3
Export aliases for ST3GAL1 gene to outside databases Previous GC identifers: GC08M134541 GC08M129786
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Summariesfor ST3GAL1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ST3GAL1 : The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its sialyltransferase activity. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: SIA4A_HUMAN, Q11201 Function : It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugarchains O-linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values
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Genomic Viewsfor ST3GAL1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000008.10 NC_018919.1 NT_008046.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ST3GAL1 gene promoter: TBP Spz1 FAC1 Pax-4a NF-kappaB1 NF-kappaB c-Ets-1 Other transcription factors Search SABiosciences Chromatin IP Primers for ST3GAL1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ST3GAL1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 8q24.22 Ensembl cytogenetic band: 8q24.22 HGNC cytogenetic band: 8q24.22 ST3GAL1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 8 GeneLoc Exon Structure
GeneLoc location for GC08M134468: view genomic region
(about GC identifiers )
Start:
134,467,091 bp from pter
End:
134,584,183 bp from pter
Size:
117,093 bases
Orientation:
minus strand
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Proteinsfor ST3GAL1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SIA4A_HUMAN, Q11201 (See
protein sequence )Recommended Name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 Size : 340 amino acids; 39075 Da
Subcellular location : Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted.Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid
Secondary accessions : O60677 Q9UN51Explore the universe of human proteins at neXtProt for ST3GAL1: NX_Q11201 Post-translational modifications:
The soluble form derives from the membrane form by proteolytic processing1
View neXtProt modification sites for NX_Q11201 4/9 DME Specific Peptides for ST3GAL1 (Q11201 ) (see all 9 )ST3GAL1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_003024.1 NP_775479.1 ENSEMBL proteins: ENSP00000428540 ENSP00000430515 ENSP00000429638 ENSP00000427720 ENSP00000429936 ENSP00000430135 ENSP00000427786 ENSP00000318445 ENSP00000414073 Reactome Protein details: Q11201 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
ST3GAL1 for ontologies About GeneDecksing ST3GAL1 Antibody Products: Assay Products for ST3GAL1:
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Protein
Domains / Familiesfor ST3GAL1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ST3GAL1 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q11201 ProtoNet protein and cluster: Q11201
1 Blocks protein family : IPB001675 Glycosyl transferase UniProtKB/Swiss-Prot: SIA4A_HUMAN, Q11201 Similarity : Belongs to the glycosyltransferase 29 family
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Functionfor ST3GAL1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: SIA4A_HUMAN, Q11201 Function : It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugarchains O-linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values Catalytic activity : CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP +alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R Enzyme Numbers (IUBMB): EC 2.4.99.4 1 2 EC 2.4.99 2
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ST3GAL1 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ST3GAL1 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): ST3GAL1 (NM_003033 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ST3GAL1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ST3GAL1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST3GAL1
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
IEA --
ST3GAL1 for ontologies About GeneDecksing 4 GenomeRNAi human phenotypes for ST3GAL1 :Animal Models: Mouse knock-out St3gal1 tm1Jxm for ST3GAL1 4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for St3gal1) :
ST3GAL1 for phenotypes About GeneDecksing
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Pathways & Interactionsfor ST3GAL1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/8 super-pathways (see all 8 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 MPS IIIC - Sanfilippo syndrome C 2 Keratan sulfate biosynthesis 3 Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein 4 Metabolism 5 Ganglio Sphingolipid Metabolism
Pathway sources See GeneCards unified pathways Show all pathways 1 BioSystems Pathway for ST3GAL1 5/22
Reactome Pathways for ST3GAL1 (see all 22 )5
Kegg Pathways (Kegg details for ST3GAL1) :UniProtKB/Swiss-Prot: SIA4A_HUMAN, Q11201 Pathway : Protein modification; protein glycosylation
ST3GAL1 for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ST3GAL1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/42 Interacting proteins for ST3GAL1 (ENSP00000318445 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 42 )
About this table Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11 ): About this table
ST3GAL1 for ontologies About GeneDecksing
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Drugs & Compoundsfor ST3GAL1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
ST3GAL1 for compounds About GeneDecksing Browse Tocris compounds for ST3GAL1 10/13 HMDB Compounds for ST3GAL1 (see all 13 ) About this table Compound Synonyms
CAS
# PubMed Ids Cytidine monophosphate 5'-CMP (see all 14 ) 63-37-6 -- Cytidine monophosphate N-acetylneuraminic acid CMP-N-acetylneuraminate (see all 6 ) 22-12-8 -- Ganglioside GM1 (18:1/12:0) 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17 ) 104443-62-1 -- Ganglioside GM1 (18:1/16:0) 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17 ) 104443-62-1 -- Ganglioside GM1 (18:1/18:0) 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17 ) 104443-62-1 -- Ganglioside GM1 (18:1/20:0) 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17 ) 104443-62-1 -- Ganglioside GM1 (18:1/22:0) 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17 ) 104443-62-1 -- Ganglioside GM1 (18:1/9Z-18:1) 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17 ) 104443-62-1 -- Ganglioside GM1 (d18:1/24:0) 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17 ) 104443-62-1 -- Ganglioside GM1 (d18:1/24:1(15Z)) 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide (see all 17 ) 104443-62-1 --
3 Novoseek chemical compound relationships for ST3GAL1 gene About this table
Search CenterWatch for drugs/clinical trials and news about ST3GAL1 / SIA4A
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Transcriptsfor ST3GAL1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ST3GAL1 gene (2 alternative transcripts): NM_003033.3 NM_173344.2 Unigene Cluster for ST3GAL1:
ST3 beta-galactoside alpha-2,3-sialyltransferase 1 Hs.374257 [show with all ESTs ] Unigene Representative Sequence: NM_003033 16 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000521180 (uc003yuk.2 uc003yum.2 ) ENST00000522652 ENST00000523854 ENST00000517668 ENST00000522204 ENST00000523634 ENST00000519924 ENST00000523855 ENST00000519435 ENST00000518298 ENST00000520020 ENST00000522873 ENST00000521627 ENST00000522285 ENST00000319914 ENST00000399640 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ST3GAL1 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ST3GAL1 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): ST3GAL1 (NM_003033 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ST3GAL1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ST3GAL1
Additional cDNA sequence: AF059321.1 AK024824.1 AK093867.1 AK311319.1 AL833743.1 BC018357.1 BC048803.1 BC063665.1 BX537506.1 BX648001.1 L13972.1 L29555.1
18 DOTS entries : DT.75185036 DT.100747437
DT.452310 DT.100036399 DT.40114271 DT.100644821 DT.100807375 DT.95138446 DT.91713477 DT.95204665 DT.95211901 DT.91713480 DT.91736839 DT.95179446 DT.101969836 DT.120636565 DT.91684832 DT.91919837 24/103 AceView cDNA sequences (see all 103 ):
AA285156 N84627 CR604109 CD370551 CN484735 NM_173344 BF434864 BQ045227 BF970833 NM_003033 BX370091 L13972 CA748607 AL709325 BI911188 BG399370 AA013421 CF785848 AW439999 BX642385 L29555 BX648001 AA085845 AL702117 GeneLoc Exon Structure 5/14 Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL1 (see all 14 ) About this scheme ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a · SP1 :       -   -     -   -   -   -   -     -   -         -               -     SP2 :       -   -     -   -   -   -   -     -   -                       -     SP3 :       -   -       -   -   -   -     -   -                           SP4 :       -   -     -   -   -   -   -     -   -   -   -   -   -   -   -   -   -   -         SP5 :       -   -     -   -   -   -   -   -   -   -                          
ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b SP1 :           SP2 :           SP3 :           SP4 :           SP5 :          
ECgene alternative splicing isoforms for ST3GAL1
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Expression for ST3GAL1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ST3GAL1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TCGTTACGCA
About this image ST3GAL1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See ST3GAL1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ST3GAL1 SOURCE GeneReport for Unigene cluster: Hs.374257 UniProtKB/Swiss-Prot: SIA4A_HUMAN, Q11201 Tissue specificity : Expressed in several tissues. Highest expression in lung, liver, skeletal muscle, kidney, pancreas,spleen and placenta SABiosciences Expression via Pathway-Focused PCR Array including ST3GAL1 : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ST3GAL1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ST3GAL1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ST3GAL1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ST3GAL1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST3GAL1
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Orthologsfor ST3GAL1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for ST3GAL1 gene from 4/12 species (see all 12 ) About this table
ENSEMBL Gene Tree for ST3GAL1 (if available)TreeFam Gene Tree for ST3GAL1 (if available)
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Paralogsfor ST3GAL1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ST3GAL1 gene ST3GAL3 2 ST6GALNAC1 2 ST3GAL6 2 ST6GALNAC2 2 ST3GAL4 2 ST3GAL5 2 ST3GAL2 2 7 SIMAP similar genes for ST3GAL1 using alignment to 6 protein entries: SIA4A_HUMAN (see all proteins ):ST3GAL4 ST3GAL6 ST3GAL2 ST6GALNAC2 ST8SIA1 ST6GALNAC1 ST8SIA5
ST3GAL1 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for ST3GAL1 PGOHUM00000245551
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Genomic Variantsfor ST3GAL1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
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Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 8 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ST3GAL1 (134467091 - 134584183 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ST3GAL1: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ST3GAL1
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Disorders
/ Diseasesfor ST3GAL1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
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ST3GAL1 for disorders About GeneDecksing
OMIM gene information: 607187
OMIM disorders : --12 diseases for ST3GAL1 : About MalaCards squamous cell carcinoma bipolar disorder graves' disease breast carcinoma colon adenocarcinoma breast cancer carcinoma colorectal cancer adenocarcinoma hypoxia immunodeficiency thyroiditis 6 Novoseek disease relationships for ST3GAL1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: ST3GAL1 (6 documents) Export disorders for ST3GAL1 gene to outside databases
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Publicationsfor ST3GAL1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ST3GAL1 gene, integrated from 9 sources (see all 42 ): (articles sorted by number of sources associating them with ST3GAL1) Utopia : connect your pdf to the dynamic world of online information
Molecular cloning and expression of Galbeta1,3GalNAc alpha2, 3- sialyltransferase from human fetal liver. (PubMed id 10504389) 1 , 2 , 3, 9 Shang J.... Jin C. (1999) Three genes that encode human beta-galactoside alpha 2,3- sialyltransferases. Structural analysis and chromosomal mapping studies. (PubMed id 7655169) 1 , 2 , 3, 9 Chang M.-L.... Lau J.T.Y. (1995) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Differential expression of five sialyltransferase genes in human tissues. (PubMed id 8027041) 1 , 2 Kitagawa H. and Paulson J.C. (1994) Family-based association study of lithium-related and other candidate genes in bipolar disorder. (PubMed id 18180429) 1 , 9 Perlis R.H....Sklar P. (2008) Sialyl-Lewis(x) on P-selectin glycoprotein ligand-1 is regulated during differentiation and maturation of dendritic cells: a mechanism involving the glycosyltransferases C2GnT1 and ST3Gal I. (PubMed id 17947642) 1 , 9 Julien S....Burchell J.M. (2007) Thyroid sialyltransferase mRNA level and activity are increased in Graves' disease. (PubMed id 16053379) 1 , 9 Kiljanski J....Bartoszewicz Z. (2005) Delineation of the minimal catalytic domain of human Galbeta1-3GalNAc alpha2,3-sialyltransferase (hST3Gal I). (PubMed id 11690653) 1 , 9 Vallejo-Ruiz V....Harduin-Lepers A. (2001) MUC1 in human and murine mammary carcinoma cells decre ases the expression of core 2 b1,6-N-acetylglucosaminyltransferase and b-galacto side a2,3-sialyltransferase. (PubMed id 22534569) 1 Solatycka A....Ugorski M. (2012) Over-expression of ST3Gal-I promotes mammary tumorige nesis. (PubMed id 20534593) 1 Picco G....Burchell J. (2010)
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External Searches for ST3GAL1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ST3GAL1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing ST3GAL1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ST3GAL1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ST3GAL1 Pharmacogenomics, SNPs, Pathways GGDB http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST3GAL1 Functional Glycomics Gateway - GTase http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_622
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About This Section Patent Information for ST3GAL1 gene: Search GeneIP for patents involving ST3GAL1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ST3GAL1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for ST3GAL1 OriGene shRNA RFP for ST3GAL1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ST3GAL1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ST3GAL1 OriGene Protein Over-expression Lysate for ST3GAL1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ST3GAL1 OriGene 3'-UTR Clone for ST3GAL1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ST3GAL1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ST3GAL1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for ST3GAL1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ST3GAL1 OriGene Custom Protein Services for ST3GAL1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ST3GAL1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ST3GAL1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ST3GAL1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ST3GAL1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ST3GAL1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ST3GAL1
Search Tocris compounds for ST3GAL1
ST3GAL1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST3GAL1
ThermoFisher Antibodies for ST3GAL1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ST3GAL1
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