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Aliases for ST3GAL1 Gene

Aliases for ST3GAL1 Gene

  • ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 1 2 3
  • Sialyltransferase 4A (Beta-Galactosidase Alpha-2,3-Sialytransferase) 2 3
  • Gal-Beta-1,3-GalNAc-Alpha-2,3-Sialyltransferase 3 4
  • Beta-Galactoside Alpha-2,3-Sialyltransferase 1 3 4
  • Alpha 2,3-ST 1 3 4
  • EC 2.4.99.4 4 63
  • Gal-NAc6S 3 4
  • ST3GalA.1 3 4
  • ST3Gal I 2 4
  • SIAT4-A 3 4
  • ST3GalI 3 4
  • SIAT4A 3 4
  • SIATFL 3 4
  • ST3O 3 4
  • CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,3-Sialyltransferase 1 3
  • Sialyltransferase 4A (Beta-Galactoside Alpha-2,3-Sialyltransferase) 3
  • Sialyltransferase 4A (Beta-Galactoside Alpha-2,3-Sialytransferase) 3
  • Sialyltransferase 4A 4
  • ST3GalIA,1 3
  • EC 2.4.99 63
  • ST3GalIA 3
  • ST3GalA 3
  • SIAT4 4

External Ids for ST3GAL1 Gene

Previous HGNC Symbols for ST3GAL1 Gene

  • SIAT4A

Previous GeneCards Identifiers for ST3GAL1 Gene

  • GC08M134541
  • GC08M129786
  • GC08M134468

Summaries for ST3GAL1 Gene

Entrez Gene Summary for ST3GAL1 Gene

  • The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its sialyltransferase activity. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST3GAL1 Gene

ST3GAL1 (ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 1) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. An important paralog of this gene is ST3GAL4.

UniProtKB/Swiss-Prot for ST3GAL1 Gene

  • It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST3GAL1 Gene

Genomics for ST3GAL1 Gene

Regulatory Elements for ST3GAL1 Gene

Genomic Location for ST3GAL1 Gene

Start:
133,454,848 bp from pter
End:
133,572,454 bp from pter
Size:
117,607 bases
Orientation:
Minus strand

Genomic View for ST3GAL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ST3GAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST3GAL1 Gene

Proteins for ST3GAL1 Gene

  • Protein details for ST3GAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q11201-SIA4A_HUMAN
    Recommended name:
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
    Protein Accession:
    Q11201
    Secondary Accessions:
    • O60677
    • Q9UN51

    Protein attributes for ST3GAL1 Gene

    Size:
    340 amino acids
    Molecular mass:
    39075 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST3GAL1 Gene

Proteomics data for ST3GAL1 Gene at MOPED

Selected DME Specific Peptides for ST3GAL1 Gene

Post-translational modifications for ST3GAL1 Gene

  • The soluble form derives from the membrane form by proteolytic processing
  • Glycosylation at Asn79, Asn114, Asn201, and Asn323
  • Modification sites at PhosphoSitePlus

Other Protein References for ST3GAL1 Gene

Domains for ST3GAL1 Gene

Gene Families for ST3GAL1 Gene

HGNC:
  • ST3G :Sialyltransferases

Protein Domains for ST3GAL1 Gene

Suggested Antigen Peptide Sequences for ST3GAL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q11201

UniProtKB/Swiss-Prot:

SIA4A_HUMAN :
  • Q11201
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST3GAL1: view

Function for ST3GAL1 Gene

Molecular function for ST3GAL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
UniProtKB/Swiss-Prot Function: It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values

Enzyme Numbers (IUBMB) for ST3GAL1 Gene

Gene Ontology (GO) - Molecular Function for ST3GAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISS --
GO:0008373 sialyltransferase activity --
genes like me logo Genes that share ontologies with ST3GAL1: view
genes like me logo Genes that share phenotypes with ST3GAL1: view

Animal Models for ST3GAL1 Gene

MGI Knock Outs for ST3GAL1:

miRNA for ST3GAL1 Gene

miRTarBase miRNAs that target ST3GAL1

No data available for Transcription Factor Targeting and HOMER Transcription for ST3GAL1 Gene

Localization for ST3GAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST3GAL1 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST3GAL1 Gene COMPARTMENTS Subcellular localization image for ST3GAL1 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ST3GAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane --
GO:0030173 integral component of Golgi membrane IEA --
genes like me logo Genes that share ontologies with ST3GAL1: view

Pathways for ST3GAL1 Gene

genes like me logo Genes that share pathways with ST3GAL1: view

UniProtKB/Swiss-Prot Q11201-SIA4A_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for ST3GAL1 Gene

Gene Ontology (GO) - Biological Process for ST3GAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006054 N-acetylneuraminate metabolic process ISS --
GO:0006464 cellular protein modification process TAS 10504389
GO:0006468 protein phosphorylation IEA --
GO:0006486 protein glycosylation --
genes like me logo Genes that share ontologies with ST3GAL1: view

Compounds for ST3GAL1 Gene

(13) HMDB Compounds for ST3GAL1 Gene

Compound Synonyms Cas Number PubMed IDs
Cytidine monophosphate
  • 5'-CMP
63-37-6
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-acetylneuraminate
22-12-8
Ganglioside GM1 (18:1/12:0)
  • 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide
104443-62-1
Ganglioside GM1 (18:1/16:0)
  • 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide
104443-62-1
Ganglioside GM1 (18:1/18:0)
  • 1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide
104443-62-1

(3) Novoseek inferred chemical compound relationships for ST3GAL1 Gene

Compound -log(P) Hits PubMed IDs
gal(beta1-3)galnac 83 1
sialic acid 66.8 4
tetracycline 29 2
genes like me logo Genes that share compounds with ST3GAL1: view

Transcripts for ST3GAL1 Gene

Unigene Clusters for ST3GAL1 Gene

ST3 beta-galactoside alpha-2,3-sialyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - - - - - - - - - - - -
SP9: - - -
SP10: -
SP11: -
SP12: - -
SP13:
SP14:

ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for ST3GAL1 Gene

GeneLoc Exon Structure for
ST3GAL1
ECgene alternative splicing isoforms for
ST3GAL1

Expression for ST3GAL1 Gene

mRNA expression in normal human tissues for ST3GAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST3GAL1 Gene

This gene is overexpressed in Heart - Left Ventricle (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ST3GAL1 Gene

SOURCE GeneReport for Unigene cluster for ST3GAL1 Gene Hs.374257

mRNA Expression by UniProt/SwissProt for ST3GAL1 Gene

Q11201-SIA4A_HUMAN
Tissue specificity: Expressed in several tissues. Highest expression in lung, liver, skeletal muscle, kidney, pancreas, spleen and placenta
genes like me logo Genes that share expressions with ST3GAL1: view

Orthologs for ST3GAL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST3GAL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST3GAL1 35
  • 98.92 (n)
  • 98.53 (a)
ST3GAL1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ST3GAL1 35
  • 86.65 (n)
  • 88.13 (a)
ST3GAL1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ST3GAL1 35
  • 87.84 (n)
  • 89.12 (a)
ST3GAL1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St3gal1 35
  • 81.9 (n)
  • 82.2 (a)
St3gal1 16
St3gal1 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ST3GAL1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ST3GAL1 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia St3gal1 35
  • 82.35 (n)
  • 82.06 (a)
chicken
(Gallus gallus)
Aves ST3GAL1 35
  • 67.16 (n)
  • 67.06 (a)
ST3GAL1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST3GAL1 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st3gal1 35
  • 64.06 (n)
  • 59.37 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6558 35
zebrafish
(Danio rerio)
Actinopterygii st3gal1l 36
  • 40 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4378 36
  • 38 (a)
OneToMany
Species with no ortholog for ST3GAL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST3GAL1 Gene

ENSEMBL:
Gene Tree for ST3GAL1 (if available)
TreeFam:
Gene Tree for ST3GAL1 (if available)

Paralogs for ST3GAL1 Gene

Selected SIMAP similar genes for ST3GAL1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ST3GAL1 Gene

genes like me logo Genes that share paralogs with ST3GAL1: view

Variants for ST3GAL1 Gene

Sequence variations from dbSNP and Humsavar for ST3GAL1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2458 -- 133,455,823(+) TTTTC(A/G/T)GGCTG utr-variant-3-prime
rs721590 -- 133,518,325(+) GCACC(A/G)ATCAG intron-variant
rs721591 -- 133,518,201(+) GAGGG(C/G)TGACC intron-variant
rs733910 -- 133,485,673(+) CCTTA(A/G)AAAAA intron-variant
rs733911 -- 133,485,799(+) GGGGA(G/T)AGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST3GAL1 Gene

Variant ID Type Subtype PubMed ID
nsv831464 CNV Loss 17160897
nsv6404 CNV Insertion 18451855
nsv6405 CNV Loss 18451855
nsv891457 CNV Loss 21882294
nsv528683 CNV Loss 19592680

Relevant External Links for ST3GAL1 Gene

HapMap Linkage Disequilibrium report
ST3GAL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST3GAL1 Gene

Disorders for ST3GAL1 Gene

(6) Novoseek inferred disease relationships for ST3GAL1 Gene

Disease -log(P) Hits PubMed IDs
colon cancer 31.2 1
carcinoma 24.4 2
breast carcinoma 22.9 3
breast cancer 21.8 2
cancer 12.3 1

Relevant External Links for ST3GAL1

Genetic Association Database (GAD)
ST3GAL1
Human Genome Epidemiology (HuGE) Navigator
ST3GAL1
genes like me logo Genes that share disorders with ST3GAL1: view

No data available for UniProtKB/Swiss-Prot for ST3GAL1 Gene

Publications for ST3GAL1 Gene

  1. Three genes that encode human beta-galactoside alpha 2,3- sialyltransferases. Structural analysis and chromosomal mapping studies. (PMID: 7655169) Chang M.-L. … Lau J.T.Y. (Glycobiology 1995) 2 3 4 23
  2. Molecular cloning and expression of Galbeta1,3GalNAc alpha2, 3- sialyltransferase from human fetal liver. (PMID: 10504389) Shang J. … Jin C. (Eur. J. Biochem. 1999) 2 3 4 23
  3. Delineation of the minimal catalytic domain of human Galbeta1-3GalNAc alpha2,3-sialyltransferase (hST3Gal I). (PMID: 11690653) Vallejo-Ruiz V. … Harduin-Lepers A. (Biochim. Biophys. Acta 2001) 3 23
  4. Sialyl-Lewis(x) on P-selectin glycoprotein ligand-1 is regulated during differentiation and maturation of dendritic cells: a mechanism involving the glycosyltransferases C2GnT1 and ST3Gal I. (PMID: 17947642) Julien S. … Burchell J.M. (J. Immunol. 2007) 3 23
  5. Family-based association study of lithium-related and other candidate genes in bipolar disorder. (PMID: 18180429) Perlis R.H. … Sklar P. (Arch. Gen. Psychiatry 2008) 3 23

Products for ST3GAL1 Gene

Sources for ST3GAL1 Gene

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