ST20-MTHFS Gene
protein-coding GIFtS: 21
GCID: GC15M080140
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ST20-MTHFS readthrough
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Aliases
for ST20-MTHFS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ST20-MTHFS Readthrough1 2 | | ST20-MTHFS Protein2 |
Export aliases for ST20-MTHFS gene to outside databasesPrevious GC identifer: GC15U901328 |
Summaries
for ST20-MTHFS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ST20-MTHFS:
This locus represents naturally occurring read-through transcription between the neighboring suppressor oftumorigenicity 20 and 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) genes onchromosome 15. The read-through transcript produces a fusion protein that shares sequence identity with eachindividual gene product. (provided by RefSeq, Dec 2010)
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Genomic Views
for ST20-MTHFS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ST20-MTHFS
Other transcription factors
Search SABiosciences Chromatin IP Primers for ST20-MTHFS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST20-MTHFS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q25.1 Ensembl cytogenetic band: 15q25.1 HGNC cytogenetic band: 15q25.1ST20-MTHFS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M080140: view genomic region
(about GC identifiers)
Start:
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80,137,537 bp from pter |
End:
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80,216,096 bp from pter |
Size:
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78,560 bases |
Orientation:
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minus strand |
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Proteins
for ST20-MTHFS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/TrEMBL: H3BQ75 (See
protein sequence)Recommended Name: 5-formyltetrahydrofolate cyclo-ligase Size: 179 amino acids; 20519 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered aspreliminary dataST20-MTHFS Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001186689.1
ENSEMBL proteins: ENSP00000455643
Human Recombinant Protein Products:
ST20-MTHFS Antibody Products:
Assay Products for ST20-MTHFS: |
Protein
Domains /
Families
for ST20-MTHFS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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ST20-MTHFS for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry H3BQ75ProtoNet protein and cluster: H3BQ75 |
Function
for ST20-MTHFS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST20-MTHFS |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005524 | ATP binding |
-- | -- | | GO:0030272 | 5-formyltetrahydrofolate cyclo-ligase activity |
-- | -- |
ST20-MTHFS for ontologies About GeneDecksing
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Pathways & Interactions
for ST20-MTHFS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | One Carbon Metabolism | |
1  BioSystems Pathway for ST20-MTHFS
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ST20-MTHFS
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0009396 | folic acid-containing compound biosynthetic process |
-- | -- |
ST20-MTHFS for ontologies About GeneDecksing
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Drugs & Compounds
for ST20-MTHFS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ST20-MTHFS
Search CenterWatch for drugs/clinical trials and news about ST20-MTHFS
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Transcripts
for ST20-MTHFS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for ST20-MTHFS gene: NM_001199760.1 2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000479961 ENST00000494999
GeneLoc Exon Structure
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Expression
for ST20-MTHFS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ST20-MTHFS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for ST20-MTHFS
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ST20-MTHFS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ST20-MTHFS | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST20-MTHFS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST20-MTHFS |
Orthologs
for ST20-MTHFS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the last universal common ancestor (LUCA).
Orthologs for ST20-MTHFS gene from 8/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MTHFS6 |
Uncharacterized protein |
58(a) |
1 → many |
10(14339193-14360237) |
lizard
(Anolis carolinensis) |
Reptilia |
MTHFS6 |
-- |
68(a) |
1 → many |
GL343332.1(424653-438210) |
zebrafish
(Danio rerio) |
Actinopterygii |
CU695017.16 |
-- |
50(a) |
1 → many |
7(11467668-11500304) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG344246 |
-- |
29(a) |
1 → many |
2R(19246742-19247789) |
worm
(Caenorhabditis elegans) |
Secernentea |
Y106G6E.46 |
Probable 5-formyltetrahydrofolate cyclo-ligase |
33(a) |
1 → many |
I(10221625-10222768) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
5-FCL6 |
5-formyltetrahydrofolate cycloligase |
19(a) |
1 → many |
5(4136556-4138792) |
rice
(Oryza sativa) |
Liliopsida |
-- |
5-formyltetrahydrofolate cyclo-ligase, putative, e... |
20(a) |
1 → many |
7(23418025-23421461) |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
fau6 |
conserved protein, 5-formyltetrahydrofolate cyclo-... |
19(a) |
1 → many |
Chromosome(3054263-3054811) |
Species with no ortholog for ST20-MTHFS
ENSEMBL Gene Tree for ST20-MTHFS (if available)
TreeFam Gene Tree for ST20-MTHFS (if available) |
Paralogs
for ST20-MTHFS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ST20-MTHFS gene
- MTHFS2
ST20-MTHFS for paralogs About GeneDecksing
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Genomic Variants
for ST20-MTHFS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for ST20-MTHFS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ST20-MTHFS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
| -- |
External Searches for ST20-MTHFS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ST20-MTHFS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing ST20-MTHFS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ST20-MTHFS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for ST20-MTHFS gene:
Search GeneIP for patents involving ST20-MTHFS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ST20-MTHFS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ST20-MTHFS | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ST20-MTHFS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST20-MTHFS | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST20-MTHFS | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST20-MTHFS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ST20-MTHFS |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST20-MTHFS |
|  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ST20-MTHFS |
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