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Aliases for ST20-MTHFS Gene

Aliases for ST20-MTHFS Gene

  • ST20-MTHFS Readthrough 2 3 5

External Ids for ST20-MTHFS Gene

Previous GeneCards Identifiers for ST20-MTHFS Gene

  • GC15U901328
  • GC15M080140

Summaries for ST20-MTHFS Gene

Entrez Gene Summary for ST20-MTHFS Gene

  • This locus represents naturally occurring read-through transcription between the neighboring suppressor of tumorigenicity 20 and 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) genes on chromosome 15. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Dec 2010]

GeneCards Summary for ST20-MTHFS Gene

ST20-MTHFS (ST20-MTHFS Readthrough) is a Protein Coding gene. Among its related pathways are One carbon pool by folate and Metabolism. An important paralog of this gene is MTHFS.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST20-MTHFS Gene

Genomics for ST20-MTHFS Gene

Regulatory Elements for ST20-MTHFS Gene

Enhancers for ST20-MTHFS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ST20-MTHFS on UCSC Golden Path with GeneCards custom track

Promoters for ST20-MTHFS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ST20-MTHFS on UCSC Golden Path with GeneCards custom track

Genomic Location for ST20-MTHFS Gene

Chromosome:
15
Start:
79,843,547 bp from pter
End:
79,923,754 bp from pter
Size:
80,208 bases
Orientation:
Minus strand

Genomic View for ST20-MTHFS Gene

Genes around ST20-MTHFS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST20-MTHFS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST20-MTHFS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST20-MTHFS Gene

Proteins for ST20-MTHFS Gene

  • Protein details for ST20-MTHFS Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYL1
    Recommended name:
    5-formyltetrahydrofolate cyclo-ligase
    Protein Accession:
    A0A0A6YYL1

    Protein attributes for ST20-MTHFS Gene

    Size:
    179 amino acids
    Molecular mass:
    20519 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
  • Protein details for ST20-MTHFS Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0U1RR23
    Recommended name:
    Protein ST20-MTHFS
    Protein Accession:
    A0A0U1RR23

    Protein attributes for ST20-MTHFS Gene

    Size:
    123 amino acids
    Molecular mass:
    14068 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST20-MTHFS Gene

Proteomics data for ST20-MTHFS Gene at MOPED

Post-translational modifications for ST20-MTHFS Gene

No Post-translational modifications

Other Protein References for ST20-MTHFS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ST20-MTHFS Gene

Domains & Families for ST20-MTHFS Gene

Protein Domains for ST20-MTHFS Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ST20-MTHFS: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ST20-MTHFS Gene

Function for ST20-MTHFS Gene

Gene Ontology (GO) - Molecular Function for ST20-MTHFS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity IEA --
genes like me logo Genes that share ontologies with ST20-MTHFS: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ST20-MTHFS Gene

Localization for ST20-MTHFS Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ST20-MTHFS Gene

Pathways & Interactions for ST20-MTHFS Gene

genes like me logo Genes that share pathways with ST20-MTHFS: view

Pathways by source for ST20-MTHFS Gene

1 BioSystems pathway for ST20-MTHFS Gene
2 KEGG pathways for ST20-MTHFS Gene

Interacting Proteins for ST20-MTHFS Gene

Gene Ontology (GO) - Biological Process for ST20-MTHFS Gene

None

No data available for SIGNOR curated interactions for ST20-MTHFS Gene

Drugs & Compounds for ST20-MTHFS Gene

No Compound Related Data Available

Transcripts for ST20-MTHFS Gene

mRNA/cDNA for ST20-MTHFS Gene

(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ST20-MTHFS Gene

No ASD Table

Relevant External Links for ST20-MTHFS Gene

GeneLoc Exon Structure for
ST20-MTHFS
ECgene alternative splicing isoforms for
ST20-MTHFS

Expression for ST20-MTHFS Gene

mRNA expression in normal human tissues for ST20-MTHFS Gene

Protein differential expression in normal tissues from HIPED for ST20-MTHFS Gene

This gene is overexpressed in Liver (19.7), Peripheral blood mononuclear cells (12.1), and Gallbladder (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb and MaxQB for ST20-MTHFS Gene



genes like me logo Genes that share expression patterns with ST20-MTHFS: view

Protein tissue co-expression partners for ST20-MTHFS Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ST20-MTHFS Gene

Orthologs for ST20-MTHFS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ST20-MTHFS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MTHFS 36
  • 69 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 70 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm2382 36
  • 70 (a)
ManyToMany
Mthfs 36
  • 70 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia MTHFS 36
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves MTHFS 36
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 67 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii MTHFS 36
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG34424 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y106G6E.4 36
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAU1 36
  • 24 (a)
OneToMany
Species with no ortholog for ST20-MTHFS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ST20-MTHFS Gene

ENSEMBL:
Gene Tree for ST20-MTHFS (if available)
TreeFam:
Gene Tree for ST20-MTHFS (if available)

Paralogs for ST20-MTHFS Gene

Paralogs for ST20-MTHFS Gene

genes like me logo Genes that share paralogs with ST20-MTHFS: view

Variants for ST20-MTHFS Gene

Structural Variations from Database of Genomic Variants (DGV) for ST20-MTHFS Gene

Variant ID Type Subtype PubMed ID
nsv833065 CNV Loss 17160897
esv28440 CNV Loss 19812545
esv2678719 CNV Deletion 23128226
nsv833066 CNV Loss 17160897
esv2660680 CNV Deletion 23128226
nsv510406 CNV Loss 20534489
esv2672391 CNV Deletion 23128226
nsv904435 CNV Gain 21882294
dgv155n21 CNV Loss 19592680

Variation tolerance for ST20-MTHFS Gene

Residual Variation Intolerance Score: 79.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.16% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for ST20-MTHFS Gene

Disorders for ST20-MTHFS Gene

Relevant External Links for ST20-MTHFS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ST20-MTHFS

No disorders were found for ST20-MTHFS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST20-MTHFS Gene

Publications for ST20-MTHFS Gene

  1. Genome-wide association study of chronic periodontitis in a general German population. (PMID: 24024966) Teumer A. … Kocher T. (J. Clin. Periodontol. 2013) 3 67

Products for ST20-MTHFS Gene

Sources for ST20-MTHFS Gene

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