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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ST20-MTHFS Gene

protein-coding   GIFtS: 30
GCID: GC15M080140

ST20-MTHFS Readthrough

Microbiology & Infectious Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
ST20-MTHFS Readthrough1 2
ST20-MTHFS Protein2
5,10-Methenyl-Tetrahydrofolate Synthetase3
EC 6.3.3.23
MTHFS3
Methenyl-THF Synthetase3

External Ids:    HGNC: 446551   Entrez Gene: 1005280212   Ensembl: ENSG000002593327   UniProtKB: P499143   
ORGUL members:         
NONCODE14:n338069 n410512      

Export aliases for ST20-MTHFS gene to outside databases

Previous GC identifer: GC15U901328


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ST20-MTHFS Gene:
This locus represents naturally occurring read-through transcription between the neighboring suppressor of
tumorigenicity 20 and 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) genes on
chromosome 15. The read-through transcript produces a fusion protein that shares sequence identity with each
individual gene product. (provided by RefSeq, Dec 2010)

GeneCards Summary for ST20-MTHFS Gene: 
ST20-MTHFS (ST20-MTHFS readthrough) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with ST20-MTHFS include pneumonia, and among its related super-pathways are One carbon pool by folate and Metabolism. An important paralog of this gene is MTHFS.

UniProtKB/Swiss-Prot: MTHFS_HUMAN, P49914
Function: Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent
one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ST20-MTHFS
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidST20-MTHFS promoter sequence
   Search SABiosciences Chromatin IP Primers for ST20-MTHFS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST20-MTHFS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.1   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q25.1

ST20-MTHFS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST20-MTHFS gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M080140:  view genomic region     (about GC identifiers)

Start:
80,135,889 bp from pter      End:
80,216,096 bp from pter
Size:
80,208 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for ST20-MTHFS

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MTHFS_HUMAN, P49914 (See protein sequence)
Recommended Name: 5-formyltetrahydrofolate cyclo-ligase  
Size: 203 amino acids; 23256 Da
Cofactor: Magnesium
Subunit: Monomer
Subcellular location: Cytoplasm
Sequence caution: Sequence=CK002935; Type=Frameshift; Positions=178, 201;
4 PDB 3D structures from and Proteopedia for ST20-MTHFS:
3HXT (3D)        3HY3 (3D)        3HY4 (3D)        3HY6 (3D)    
Secondary accessions: H3BQ75
Alternative splicing: 2 isoforms:  P49914-1   P49914-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ST20-MTHFS: NX_P49914

Explore proteomics data for ST20-MTHFS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49914

  • ST20-MTHFS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ST20-MTHFS Protein Expression
    REFSEQ proteins: NP_001186689.1  
    ENSEMBL proteins: 
     ENSP00000455643  

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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus ----
    GO:0005829cytosol ----
    GO:0005886plasma membrane ----

    ST20-MTHFS for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR002698 FTHF_cligase
     IPR024185 FTHF_cligase-like

    Graphical View of Domain Structure for InterPro Entry P49914

    ProtoNet protein and cluster: P49914

    1 Blocks protein domain: IPB002698 5-formyltetrahydrofolate cyclo-ligase

    UniProtKB/Swiss-Prot: MTHFS_HUMAN, P49914
    Similarity: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family


    ST20-MTHFS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTHFS_HUMAN, P49914
    Function: Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent
    one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids
    Catalytic activity: ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate

         Enzyme Number (IUBMB): EC 6.3.3.21

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding ----
    GO:0005542folic acid binding ----
    GO:00302725-formyltetrahydrofolate cyclo-ligase activity ----
         
    ST20-MTHFS for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ST20-MTHFS About                                                                                                See pathways by source

    SuperPathContained pathways About
    1One Carbon Metabolism
    One Carbon Metabolism0.53
    One carbon pool by folate0.53
    2Metabolism
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ST20-MTHFS
        One Carbon Metabolism


    2         Kegg Pathways  (Kegg details for ST20-MTHFS):
        One carbon pool by folate
    Metabolic pathways


    ST20-MTHFS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ST20-MTHFS

    1 Interacting protein for ST20-MTHFS (P499143) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSC22D4Q9Y3Q83I2D: score=4 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009396folic acid-containing compound biosynthetic process ----
    GO:0015942formate metabolic process ----
    GO:0046653tetrahydrofolate metabolic process ----

    ST20-MTHFS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ST20-MTHFS (MTHFS)

    Search CenterWatch for drugs/clinical trials and news about ST20-MTHFS / MTHFS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for ST20-MTHFS gene: 
    NM_001199760.1  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479961 ENST00000494999
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate ST20-MTHFS:
    hsa-miR-21* hsa-miR-514 hsa-miR-514b-3p
    SwitchGear 3'UTR luciferase reporter plasmidST20-MTHFS 3' UTR sequence
    Inhib. RNA
    Products:
         
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ST20-MTHFS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ST20-MTHFS Expression
    About this image


    See ST20-MTHFS Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for ST20-MTHFS
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ST20-MTHFS gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves MTHFS6
    Uncharacterized protein
    56(a)
    1 → many
    10(12133660-12155156)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    64(a)
    1 → many
    GL343332.1(424653-462414)
    zebrafish
    (Danio rerio)
    Actinopterygii MTHFS6
    5,10-methenyltetrahydrofolate synthetase (5-formyl...
    50(a)
    1 → many
    7(11467668-11500304)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG344246
    --
    29(a)
    1 → many
    2R(19246742-19247789)
    worm
    (Caenorhabditis elegans)
    Secernentea Y106G6E.46
    Probable 5-formyltetrahydrofolate cyclo-ligase
    31(a)
    1 → many
    I(10221635-10222778)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAU16
    5,10-methenyltetrahydrofolate synthetase, involved...
    24(a)
    1 → many
    V(553334-553969)
            Species with no ortholog for ST20-MTHFS

    ENSEMBL Gene Tree for ST20-MTHFS (if available)
    TreeFam Gene Tree for ST20-MTHFS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ST20-MTHFS gene
    MTHFS2  

    ST20-MTHFS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ST20-MTHFS:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672391CNV Deletion23128226
    esv2660680CNV Deletion23128226
    esv2678719CNV Deletion23128226
    esv28440CNV Loss19812545
    nsv833065CNV Loss17160897
    dgv155n21CNV Loss19592680
    nsv833066CNV Loss17160897
    nsv510406CNV Loss20534489
    nsv904435CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ST20-MTHFS:    About MalaCards
    pneumonia    


    ST20-MTHFS for disorders           About GeneDecksing


    Export disorders for ST20-MTHFS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ST20-MTHFS gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ST20-MTHFS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    2. Structural basis for the inhibition of human 5,10- methenyltetrahydrofolate synthetase by N10-substituted folate analogues. (PubMed id 19738041)2 Wu D....Liu Z.-J. (2009)
    3. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Cloning and characterization of the human 5,10- methenyltetrahydrofolate synthetase-encoding cDNA. (PubMed id 8522195)2 Dayan A.... Jolivet J. (1995)
    7. Human liver methenyltetrahydrofolate synthetase: improved purification and increased affinity for folate polyglutamate substrates. (PubMed id 3801490)2 Bertrand R.... Jolivet J. (1987)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100528021 HGNC: 44655 Ensembl:ENSG00000259332 euGenes: HUgn100528021 ECgene: ST20-MTHFS Kegg: 100528021
    H-InvDB: ST20-MTHFS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ST20-MTHFS gene:
    Search GeneIP for patents involving ST20-MTHFS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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