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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ST20 Gene

protein-coding GIFtS: 40
GCID: GC15M080191

suppressor of tumorigenicity 20

Explore 2 diseases affiliated with
ST20 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Suppressor Of Tumorigenicity 20¹ ²
HCCS-1¹ ² ³
Human Cervical Cancer Suppressor Gene 1 Protein² ³
Cervical Cancer Suppressor-1²
Suppressor Of Tumorigenicity 20 Protein²
HCCS1³

External Ids:	HGNC: 33520¹	Entrez Gene: 400410²	Ensembl: ENSG00000180953⁷	UniProtKB: Q9HBF5³

ORGUL members:
	NONCODE:n410510

Export aliases for ST20 gene to outside databases

Previous GC identifers: GC15M077980 GC15M056949

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ST20_HUMAN, Q9HBF5

Function: May act as a tumor suppressor. Promotes apoptosis of cancer cells

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ST20 gene promoter:
E2F-4 E2F-3a NF-1 E2F-1 E2F E2F-2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for ST20

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST20

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.1 Ensembl cytogenetic band: 15q25.1 HGNC cytogenetic band: 15q25.1

ST20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST20 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M080191: view genomic region (about GC identifiers)

Start:	80,191,182 bp from pter	End:	80,216,077 bp from pter
Size:	24,896 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ST20_HUMAN, Q9HBF5 (See protein sequence)

Recommended Name: Suppressor of tumorigenicity 20 protein

Size: 79 amino acids; 9024 Da

Explore the universe of human proteins at neXtProt for ST20: NX_Q9HBF5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HBF5

ST20 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins (3 alternative transcripts):

NP_001094349.1 NP_001094350.1 NP_001186686.1

ENSEMBL proteins:

ENSP00000457965 ENSP00000453502 ENSP00000453693

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	Uscn ELISAs and CLIAs for ST20

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ST20 for domains About GeneDecksing

2 InterPro domains/families:

IPR026298 Blc2_fam

IPR026301 ST20

Graphical View of Domain Structure for InterPro Entry Q9HBF5

ProtoNet protein and cluster: Q9HBF5

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ST20_HUMAN, Q9HBF5

Function: May act as a tumor suppressor. Promotes apoptosis of cancer cells

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ST20 Browse MicroRNA Expression Plasmids
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

glycine biosynthesis I

folate transformations I

0.33

1 BioSystems Pathway for ST20

folate transformations I

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ST20

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0042981	regulation of apoptotic process	IEA	--

ST20 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ST20
Search CenterWatch for drugs/clinical trials and news about ST20

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ST20 gene (3 alternative transcripts):

NM_001100879.1 NM_001100880.2 NM_001199757.1

Unigene Cluster for ST20:

Suppressor of tumorigenicity 20

Hs.729127 [show with all ESTs]

Unigene Representative Sequence: AL109714

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000562759(uc021srs.1 uc021srt.1) ENST00000478497(uc002bez.4)

ENST00000485386(uc021sru.1 uc002bfa.4)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ST20 Browse OriGene MicroRNA Expression Plasmids
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Additional cDNA sequence:

AF249277.1 AL109714.1 NR_037652.1 NR_037653.1

7 DOTS entries:

DT.412135 DT.92456933 DT.95263213 DT.95203357 DT.92456955 DT.99997793 DT.92456941

24/307 AceView cDNA sequences (see all 307):

AI129743 BU077484 BM674537 BM510737 BM769396 AI090295 AA807026 BM450865

R14575 BM830783 AL109714 AI188428 AI420454 AA701992 AI160812 BM830804

BM507216 BM823153 BM508087 AA765734 BM823582 CK905549 AW273775 BM769301

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ST20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGGAGTGC

About this image
Genevestigator expression for ST20

SOURCE GeneReport for Unigene cluster: Hs.729127

UniProtKB/Swiss-Prot: ST20_HUMAN, Q9HBF5

Tissue specificity: Expressed in leukocytes, lung, spleen, liver, heart, kidney, muscle and uterine cervix.

Down-regulated in cervical cancer

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for ST20 (if available)
TreeFam Gene Tree for ST20 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs151136832^1,2		--	80191656(+)	`AAGTAC/TAAAAA`	6	--	int¹		0	--	--	--	--
rs4485317^1,2	C,F,A,H,	--	80191686(+)	`AGATAT/CATTTA`	6	--	int¹		9		NA CSA WA EA	371
rs200606391^1,2		--	80191686(+)	`AGATA-/TATT TAGTG`	6	--	int¹		0	--	--	--	--
rs187918791^1,2		--	80191792(+)	`ACAGCA/GTATCT`	6	--	int¹		0	--	--	--	--
rs72478413^1,2	C,F,	--	80191862(+)	`AAAAAG/ATCTTT`	6	--	int¹		2		NA CSA	4
rs11856527^1,2	C,F,H,	--	80191864(+)	`AAAGTC/ATTTTT`	6	--	int¹		2		NA CSA	7
rs143254917^1,2	C,	--	80191868(+)	`TCTTT-/TTGTTC TTGTT`	6	--	int¹		0	--	--	--	--
rs73474599^1,2	C,F,	--	80191915(+)	`CACTTG/ATATTT`	6	--	int¹		2		WA	4
rs190330911^1,2		--	80191932(+)	`TGAATC/TCTATT`	6	--	int¹		0	--	--	--	--
rs181682965^1,2		--	80191942(+)	`TATACC/TGTAAA`	6	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ST20 (80191182 - 80216077 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ST20
2 CNVs: 77016 87764

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ST20

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ST20 for disorders About GeneDecksing

2 diseases for ST20: About MalaCards

cervical cancer cervicitis

1 disease from the University of Copenhagen DISEASES database for ST20:

Brugada syndrome

Export disorders for ST20 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ST20 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ST20)

Utopia: connect your pdf to the dynamic
world of online information

Candidate tumor suppressor, HCCS-1, is downregulated in human cancers and induces apoptosis in cervical cancer. (PubMed id 11857354)^{1, 2} Kim T.E.... Kim J.W. (2002)
Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)¹ Prakash T....Taylor T.D. (2010)
Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)² Zody M.C....Nusbaum C. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 400410	HGNC: 33520	AceView: MTHFS	Ensembl:ENSG00000180953	euGenes: HUgn400410
ECgene: ST20	H-InvDB: ST20

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ST20	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ST20 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ST20 gene:
Search GeneIP for patents involving ST20

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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ST20 Gene

suppressor of tumorigenicity 20

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ST20 Gene

suppressor of tumorigenicity 20

Aliasesfor ST20 gene

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for ST20 gene

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for ST20 gene

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for ST20 gene

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for ST20 gene

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for ST20 gene

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for ST20 gene

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for ST20 gene

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for ST20 gene

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for ST20 gene

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for ST20 gene

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for ST20 gene

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for ST20 gene

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for ST20 gene

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for ST20 gene

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for ST20 gene