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Aliases for ST20 Gene

Aliases for ST20 Gene

  • Suppressor Of Tumorigenicity 20 2 3 5
  • Human Cervical Cancer Suppressor Gene 1 Protein 3 4
  • HCCS-1 3 4
  • Cervical Cancer Suppressor-1 3
  • HCCS1 4

External Ids for ST20 Gene

Previous GeneCards Identifiers for ST20 Gene

  • GC15M077980
  • GC15M080191
  • GC15M056949

Summaries for ST20 Gene

GeneCards Summary for ST20 Gene

ST20 (Suppressor Of Tumorigenicity 20) is a Protein Coding gene. Diseases associated with ST20 include Pontocerebellar Hypoplasia, Type 2E and Brugada Syndrome. Among its related pathways are One carbon pool by folate. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity.

UniProtKB/Swiss-Prot for ST20 Gene

  • May act as a tumor suppressor. Promotes apoptosis of cancer cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST20 Gene

Genomics for ST20 Gene

Regulatory Elements for ST20 Gene

Enhancers for ST20 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ST20 on UCSC Golden Path with GeneCards custom track

Promoters for ST20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ST20 on UCSC Golden Path with GeneCards custom track

Genomic Location for ST20 Gene

79,898,840 bp from pter
79,923,754 bp from pter
24,915 bases
Minus strand

Genomic View for ST20 Gene

Genes around ST20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST20 Gene

Proteins for ST20 Gene

  • Protein details for ST20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Suppressor of tumorigenicity 20 protein
    Protein Accession:

    Protein attributes for ST20 Gene

    79 amino acids
    Molecular mass:
    9024 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST20 Gene

Proteomics data for ST20 Gene at MOPED

Post-translational modifications for ST20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ST20 Gene

No data available for DME Specific Peptides for ST20 Gene

Domains & Families for ST20 Gene

Protein Domains for ST20 Gene


Suggested Antigen Peptide Sequences for ST20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ST20: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ST20 Gene

Function for ST20 Gene

Molecular function for ST20 Gene

UniProtKB/Swiss-Prot Function:
May act as a tumor suppressor. Promotes apoptosis of cancer cells.

Gene Ontology (GO) - Molecular Function for ST20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015267 channel activity IBA --
genes like me logo Genes that share ontologies with ST20: view
genes like me logo Genes that share phenotypes with ST20: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ST20 Gene

Localization for ST20 Gene

Subcellular locations from

Jensen Localization Image for ST20 Gene COMPARTMENTS Subcellular localization image for ST20 gene
Compartment Confidence
mitochondrion 4
extracellular 3
cytosol 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ST20 Gene

Pathways & Interactions for ST20 Gene

SuperPathways for ST20 Gene

Superpath Contained pathways
1 One carbon pool by folate
genes like me logo Genes that share pathways with ST20: view

Pathways by source for ST20 Gene

1 BioSystems pathway for ST20 Gene

Interacting Proteins for ST20 Gene

Gene Ontology (GO) - Biological Process for ST20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008053 mitochondrial fusion IBA --
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA --
GO:0043065 positive regulation of apoptotic process IBA --
genes like me logo Genes that share ontologies with ST20: view

No data available for SIGNOR curated interactions for ST20 Gene

Drugs & Compounds for ST20 Gene

No Compound Related Data Available

Transcripts for ST20 Gene

Unigene Clusters for ST20 Gene

Suppressor of tumorigenicity 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ST20 Gene

No ASD Table

Relevant External Links for ST20 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ST20 Gene

mRNA expression in normal human tissues for ST20 Gene

mRNA differential expression in normal tissues according to GTEx for ST20 Gene

This gene is overexpressed in Whole Blood (x17.6).

SOURCE GeneReport for Unigene cluster for ST20 Gene Hs.729127

mRNA Expression by UniProt/SwissProt for ST20 Gene

Tissue specificity: Expressed in leukocytes, lung, spleen, liver, heart, kidney, muscle and uterine cervix. Down-regulated in cervical cancer.
genes like me logo Genes that share expression patterns with ST20: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ST20 Gene

Orthologs for ST20 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ST20 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ST20 35
  • 99.58 (n)
  • 98.73 (a)
ST20 36
  • 99 (a)
Species with no ortholog for ST20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ST20 Gene

Gene Tree for ST20 (if available)
Gene Tree for ST20 (if available)

Paralogs for ST20 Gene

No data available for Paralogs for ST20 Gene

Variants for ST20 Gene

Sequence variations from dbSNP and Humsavar for ST20 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_044034 -
rs149636034 -- 79,925,422(+) AGTGA(C/T)CCAGT upstream-variant-2KB
rs144412038 -- 79,925,431(+) GTTCT(A/T)TTACA upstream-variant-2KB
rs556956526 -- 79,925,650(+) TTCAA(C/T)AGGTG upstream-variant-2KB
rs78645649 -- 79,925,500(+) CTTAG(C/T)TTCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ST20 Gene

Variant ID Type Subtype PubMed ID
nsv833065 CNV Loss 17160897
nsv833066 CNV Loss 17160897
esv2660680 CNV Deletion 23128226
nsv510406 CNV Loss 20534489
esv2672391 CNV Deletion 23128226
nsv904435 CNV Gain 21882294
dgv155n21 CNV Loss 19592680

Variation tolerance for ST20 Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.80; 86.82% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ST20 Gene

Disorders for ST20 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ST20 Gene - From: OMIM and DISEASES

Disorder Aliases PubMed IDs
pontocerebellar hypoplasia, type 2e
  • pontocerebellar hypoplasia type 2a
brugada syndrome
  • sudden unexpected nocturnal death syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ST20 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ST20

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ST20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST20 Gene

Publications for ST20 Gene

  1. Candidate tumor suppressor, HCCS-1, is downregulated in human cancers and induces apoptosis in cervical cancer. (PMID: 11857354) Kim T.E. … Kim J.W. (Int. J. Cancer 2002) 3 4 67
  2. Genome-wide association study of chronic periodontitis in a general German population. (PMID: 24024966) Teumer A. … Kocher T. (J. Clin. Periodontol. 2013) 3
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3

Products for ST20 Gene

Sources for ST20 Gene