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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ST20 Gene

protein-coding   GIFtS: 39
GCID: GC15M080191

Suppressor Of Tumorigenicity 20

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Suppressor Of Tumorigenicity 201 2
Human Cervical Cancer Suppressor Gene 1 Protein2 3
HCCS-12 3
Cervical Cancer Suppressor-12
Suppressor Of Tumorigenicity 20 Protein2
HCCS13

External Ids:    HGNC: 335201   Entrez Gene: 4004102   Ensembl: ENSG000001809537   UniProtKB: Q9HBF53   
ORGUL members:         
NONCODE14:n410510      

Export aliases for ST20 gene to outside databases

Previous GC identifers: GC15M077980 GC15M056949


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ST20 Gene: 
ST20 (suppressor of tumorigenicity 20) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with ST20 include cervical cancer, and cervicitis, and among its related super-pathways are folate polyglutamylation.

UniProtKB/Swiss-Prot: ST20_HUMAN, Q9HBF5
Function: May act as a tumor suppressor. Promotes apoptosis of cancer cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ST20 gene promoter:
         E2F-4   E2F-3a   NF-1   E2F-1   E2F   E2F-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ST20

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.1   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q25.1

ST20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST20 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M080191:  view genomic region     (about GC identifiers)

Start:
80,191,182 bp from pter      End:
80,216,096 bp from pter
Size:
24,915 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ST20_HUMAN, Q9HBF5 (See protein sequence)
Recommended Name: Suppressor of tumorigenicity 20 protein  
Size: 79 amino acids; 9024 Da

Explore the universe of human proteins at neXtProt for ST20: NX_Q9HBF5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HBF5

  • ST20 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins (3 alternative transcripts): 
    NP_001094349.1  NP_001094350.1  NP_001186686.1  

    ENSEMBL proteins: 
     ENSP00000457965   ENSP00000453502   ENSP00000453693  

    Human Recombinant Protein Products for ST20: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR026298 Blc2_fam
     IPR026301 ST20

    Graphical View of Domain Structure for InterPro Entry Q9HBF5

    ProtoNet protein and cluster: Q9HBF5


    ST20 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST20_HUMAN, Q9HBF5
    Function: May act as a tumor suppressor. Promotes apoptosis of cancer cells

    Animal Models:

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ST20 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ST20 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1glycine biosynthesis I
    folate transformations I0.43


    1 BioSystems Pathway for ST20
        folate transformations I


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ST20

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042981regulation of apoptotic process IEA--

    ST20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ST20

    Search CenterWatch for drugs/clinical trials and news about ST20

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ST20 gene (3 alternative transcripts): 
    NM_001100879.1  NM_001100880.2  NM_001199757.1  

    Unigene Cluster for ST20:

    Suppressor of tumorigenicity 20
    Hs.729127  [show with all ESTs]
    Unigene Representative Sequence: AL109714
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000562759(uc021srs.1 uc021srt.1) ENST00000478497(uc002bez.4)
    ENST00000485386(uc021sru.1 uc002bfa.4)
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF249277.1 AL109714.1 NR_037652.1 NR_037653.1 

    7 DOTS entries:

    DT.412135  DT.92456933  DT.95263213  DT.95203357  DT.92456955  DT.99997793  DT.92456941 

    24/307 AceView cDNA sequences (see all 307):

    AA700046 AW161062 BG939662 AI754307 BQ777753 AI674201 BM823149 CA848720 
    AA668859 AI373513 AI632437 BM831179 AW612037 AI129743 BM674537 BU077484 
    BM510737 BM769396 AI090295 AA807026 BM450865 R14575 BM830783 AL109714 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ST20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGAGTGC
    ST20 Expression
    About this image


    Genevestigator expression for ST20

    SOURCE GeneReport for Unigene cluster: Hs.729127

    UniProtKB/Swiss-Prot: ST20_HUMAN, Q9HBF5
    Tissue specificity: Expressed in leukocytes, lung, spleen, liver, heart, kidney, muscle and uterine cervix.
    Down-regulated in cervical cancer

        SABiosciences Custom PCR Arrays for ST20
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for ST20 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia ST201 suppressor of tumorigenicity 20 99.58(n)
    98.73(a)
      100609733  XM_003314812.1  XP_003314860.1 


    ENSEMBL Gene Tree for ST20 (if available)
    TreeFam Gene Tree for ST20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    8 SNPs in ST20 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0440344
    ----see VAR_0440342 P L mis40--------
    rs1496360341,2
    --80217764(+) AGTGAC/TCCAGT 2 -- us2k10--------
    rs1444120381,2
    --80217773(+) GTTCTA/TTTACA 2 -- us2k10--------
    rs786456491,2
    C,F--80217842(+) CTTAGT/CTTCCT 2 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1468155441,2
    C--80218039(+) ATTAT-/TTTG  
            
    TTTGT
    2 -- us2k10--------
    rs3734098301,2
    ----80218042(+) TGTTT-/GTTT  
            
    TTGTC
    2 -- us2k10--------
    rs784861651,2
    ----80218049(+) TGTTT-/GTTT  
            
    TTGTC
    2 -- us2k10--------
    rs2002086471,2
    ----80217711(+) GCTTCA/GGCCTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ST20 (80191182 - 80216096 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ST20:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672391CNV Deletion23128226
    esv2660680CNV Deletion23128226
    dgv155n21CNV Loss19592680
    nsv833065CNV Loss17160897
    nsv833066CNV Loss17160897
    nsv510406CNV Loss20534489
    nsv904435CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for ST20:    About MalaCards
    cervical cancer    cervicitis    brugada syndrome

    1 disease from the University of Copenhagen DISEASES database for ST20:
    Brugada syndrome

    ST20 for disorders           About GeneDecksing


    Export disorders for ST20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ST20 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ST20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Candidate tumor suppressor, HCCS-1, is downregulated in human cancers and induces apoptosis in cervical cancer. (PubMed id 11857354)1, 2 Kim T.E.... Kim J.W. (2002)
    2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
    3. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 400410 HGNC: 33520 AceView: MTHFS Ensembl:ENSG00000180953 euGenes: HUgn400410
    ECgene: ST20 H-InvDB: ST20

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ST20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ST20 gene:
    Search GeneIP for patents involving ST20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST20
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ST20
     Browse SwitchGear Promoter luciferase reporter plasmids for ST20
     Search ThermoFisher Antibodies for ST20
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ST20
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ST20
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ST20
    Customized:
     lentivirus for stable overexpression of ST20
     lentivirus expression plasmids for stable overexpression of ST20
     adenovirus for overexpression of ST20
     Search LSBio for Antibodies for ST20
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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