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Aliases for ST20 Gene

Aliases for ST20 Gene

  • Suppressor Of Tumorigenicity 20 2 3 5
  • Human Cervical Cancer Suppressor Gene 1 Protein 3 4
  • HCCS-1 3 4
  • Suppressor Of Tumorigenicity 20 Protein 3
  • Cervical Cancer Suppressor-1 3
  • HCCS1 4

External Ids for ST20 Gene

Previous GeneCards Identifiers for ST20 Gene

  • GC15M077980
  • GC15M080191
  • GC15M056949

Summaries for ST20 Gene

GeneCards Summary for ST20 Gene

ST20 (Suppressor Of Tumorigenicity 20) is a Protein Coding gene. Among its related pathways are One carbon pool by folate. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is BCL2A1.

UniProtKB/Swiss-Prot for ST20 Gene

  • May act as a tumor suppressor. Promotes apoptosis of cancer cells.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST20 Gene

Genomics for ST20 Gene

Regulatory Elements for ST20 Gene

Enhancers for ST20 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G079894 1.4 ENCODE dbSUPER 31.9 +26.5 26515 5.5 HNRNPUL1 FOXA2 CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 MTHFS ST20 BCL2A1 ZFAND6 RNU6-667P KIAA1024 ENSG00000279394
GH15G079921 1.1 ENCODE 31.9 +0.4 411 2.9 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 ZNF207 MTHFS ST20 BCL2A1 ST20-AS1 ST20-MTHFS
GH15G079903 0.7 Ensembl dbSUPER 32.8 +19.7 19654 0.6 SCRT1 PRDM6 SCRT2 ST20 BCL2A1 RNU6-667P MTHFS GC15M079918
GH15G079964 1.7 FANTOM5 ENCODE dbSUPER 9.8 -44.6 -44569 7.5 HDGF PKNOX1 FOXA2 WRNIP1 SIN3A YY1 ZNF143 ZNF207 FOS JUNB BCL2A1 MTHFS ST20-MTHFS ST20 RNU6-667P LOC101929560 ZFAND6 GC15P079945
GH15G079883 0.9 ENCODE 18.1 +38.0 37963 5.4 PKNOX1 FOXA2 ATF1 YY1 FOS ZNF579 MIER3 ATF4 NR2C1 HNF4A MTHFS ST20 BCL2A1 RNU6-667P ZFAND6 KIAA1024 ENSG00000279394
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ST20 on UCSC Golden Path with GeneCards custom track

Promoters for ST20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000079878 354 2401 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 ZNF207

Genomic Location for ST20 Gene

Chromosome:
15
Start:
79,898,840 bp from pter
End:
79,923,754 bp from pter
Size:
24,915 bases
Orientation:
Minus strand

Genomic View for ST20 Gene

Genes around ST20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST20 Gene

Proteins for ST20 Gene

  • Protein details for ST20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBF5-ST20_HUMAN
    Recommended name:
    Suppressor of tumorigenicity 20 protein
    Protein Accession:
    Q9HBF5

    Protein attributes for ST20 Gene

    Size:
    79 amino acids
    Molecular mass:
    9024 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST20 Gene

Post-translational modifications for ST20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ST20 Gene

No data available for DME Specific Peptides for ST20 Gene

Domains & Families for ST20 Gene

Protein Domains for ST20 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for ST20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ST20: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ST20 Gene

Function for ST20 Gene

Molecular function for ST20 Gene

UniProtKB/Swiss-Prot Function:
May act as a tumor suppressor. Promotes apoptosis of cancer cells.
genes like me logo Genes that share phenotypes with ST20: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ST20 Gene

Localization for ST20 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST20 gene
Compartment Confidence
extracellular 3
mitochondrion 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ST20 Gene

Pathways & Interactions for ST20 Gene

SuperPathway Contained pathways
1 One carbon pool by folate
genes like me logo Genes that share pathways with ST20: view

Pathways by source for ST20 Gene

1 BioSystems pathway for ST20 Gene

Interacting Proteins for ST20 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000453502%0d%0a9606.ENSP00000307666%0d%0a9606.ENSP00000401435%0d%0a
Selected Interacting proteins: ENSP00000453502 Q9HBF5-ST20_HUMAN for ST20 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ST20 Gene

None

No data available for SIGNOR curated interactions for ST20 Gene

Drugs & Compounds for ST20 Gene

No Compound Related Data Available

Transcripts for ST20 Gene

Unigene Clusters for ST20 Gene

Suppressor of tumorigenicity 20:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST20 Gene

No ASD Table

Relevant External Links for ST20 Gene

GeneLoc Exon Structure for
ST20
ECgene alternative splicing isoforms for
ST20

Expression for ST20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST20 Gene

mRNA differential expression in normal tissues according to GTEx for ST20 Gene

This gene is overexpressed in Whole Blood (x17.6).

NURSA nuclear receptor signaling pathways regulating expression of ST20 Gene:

ST20

SOURCE GeneReport for Unigene cluster for ST20 Gene:

Hs.729127

mRNA Expression by UniProt/SwissProt for ST20 Gene:

Q9HBF5-ST20_HUMAN
Tissue specificity: Expressed in leukocytes, lung, spleen, liver, heart, kidney, muscle and uterine cervix. Down-regulated in cervical cancer.
genes like me logo Genes that share expression patterns with ST20: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST20 Gene

Orthologs for ST20 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ST20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST20 34 35
  • 99.58 (n)
Species where no ortholog for ST20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ST20 Gene

ENSEMBL:
Gene Tree for ST20 (if available)
TreeFam:
Gene Tree for ST20 (if available)

Paralogs for ST20 Gene

Paralogs for ST20 Gene

genes like me logo Genes that share paralogs with ST20: view

Variants for ST20 Gene

Sequence variations from dbSNP and Humsavar for ST20 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000064758 -- 79,918,337(+) AGCCC(C/T)ACCAC intron-variant
rs1000094335 -- 79,925,469(+) ATTTG(C/T)TTCTA upstream-variant-2KB
rs1000100403 -- 79,918,144(+) GTATC(G/T)TTTTG intron-variant
rs1000218561 -- 79,911,716(+) GCGGC(A/C/G)TGTGC intron-variant
rs1000298401 -- 79,906,624(+) AGCTG(A/C)GATCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST20 Gene

Variant ID Type Subtype PubMed ID
dgv155n21 CNV loss 19592680
esv2660680 CNV deletion 23128226
esv2672391 CNV deletion 23128226
esv3581779 CNV loss 25503493
esv3637009 CNV loss 21293372
esv3637011 CNV loss 21293372
nsv510406 OTHER sequence alteration 20534489
nsv833065 CNV loss 17160897
nsv833066 CNV loss 17160897

Variation tolerance for ST20 Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.80; 86.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ST20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST20 Gene

Disorders for ST20 Gene

Relevant External Links for ST20

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ST20

No disorders were found for ST20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST20 Gene

Publications for ST20 Gene

  1. Candidate tumor suppressor, HCCS-1, is downregulated in human cancers and induces apoptosis in cervical cancer. (PMID: 11857354) Kim T.E. … Kim J.W. (Int. J. Cancer 2002) 2 3 4 64
  2. Genome-wide association study of chronic periodontitis in a general German population. (PMID: 24024966) Teumer A. … Kocher T. (J. Clin. Periodontol. 2013) 3 64
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 4 64

Products for ST20 Gene

Sources for ST20 Gene

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