Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ST20 Gene

Aliases for ST20 Gene

  • Suppressor Of Tumorigenicity 20 2 3
  • Human Cervical Cancer Suppressor Gene 1 Protein 3 4
  • HCCS-1 3 4
  • Suppressor Of Tumorigenicity 20 Protein 3
  • Cervical Cancer Suppressor-1 3
  • KIAA0807 6
  • MAST205 6
  • MAST2 6
  • HCCS1 4

External Ids for ST20 Gene

Summaries for ST20 Gene

GeneCards Summary for ST20 Gene

ST20 (Suppressor Of Tumorigenicity 20) is a Protein Coding gene. Among its related pathways are folate polyglutamylation.

UniProtKB/Swiss-Prot for ST20 Gene

  • May act as a tumor suppressor. Promotes apoptosis of cancer cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST20 Gene

Genomics for ST20 Gene

Genomic Location for ST20 Gene

Start:
79,898,840 bp from pter
End:
79,923,754 bp from pter
Size:
24,915 bases
Orientation:
Minus strand

Genomic View for ST20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ST20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST20 Gene

Regulatory Elements for ST20 Gene

Proteins for ST20 Gene

  • Protein details for ST20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBF5-ST20_HUMAN
    Recommended name:
    Suppressor of tumorigenicity 20 protein
    Protein Accession:
    Q9HBF5
    Secondary Accessions:

    Protein attributes for ST20 Gene

    Size:
    79 amino acids
    Molecular mass:
    9024 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST20 Gene

Proteomics data for ST20 Gene at MOPED

Post-translational modifications for ST20 Gene

No Post-translational modifications

Other Protein References for ST20 Gene

No data available for DME Specific Peptides for ST20 Gene

Domains for ST20 Gene

Protein Domains for ST20 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with ST20: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ST20 Gene

Function for ST20 Gene

Molecular function for ST20 Gene

UniProtKB/Swiss-Prot Function: May act as a tumor suppressor. Promotes apoptosis of cancer cells.

Gene Ontology (GO) - Molecular Function for ST20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IBA --
GO:0046982 protein heterodimerization activity IBA --
genes like me logo Genes that share ontologies with ST20: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ST20 Gene

Localization for ST20 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST20 Gene COMPARTMENTS Subcellular localization image for ST20 gene
Compartment Confidence
extracellular 3
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ST20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IBA --
genes like me logo Genes that share ontologies with ST20: view

Pathways for ST20 Gene

SuperPathways for ST20 Gene

Superpath Contained pathways
1 folate polyglutamylation
genes like me logo Genes that share pathways with ST20: view

Pathways by source for ST20 Gene

1 BioSystems pathway for ST20 Gene

Interacting Proteins for ST20 Gene

Gene Ontology (GO) - Biological Process for ST20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA --
GO:0043066 negative regulation of apoptotic process IBA --
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IBA --
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway IBA --
genes like me logo Genes that share ontologies with ST20: view

Transcripts for ST20 Gene

Unigene Clusters for ST20 Gene

Suppressor of tumorigenicity 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ST20 Gene

No ASD Table

Relevant External Links for ST20 Gene

GeneLoc Exon Structure for
ST20
ECgene alternative splicing isoforms for
ST20

Expression for ST20 Gene

mRNA expression in normal human tissues for ST20 Gene

mRNA differential expression in normal tissues according to GTEx for ST20 Gene

This gene is overexpressed in Whole Blood (17.6).

SOURCE GeneReport for Unigene cluster for ST20 Gene Hs.729127

mRNA Expression by UniProt/SwissProt for ST20 Gene

Q9HBF5-ST20_HUMAN
Tissue specificity: Expressed in leukocytes, lung, spleen, liver, heart, kidney, muscle and uterine cervix. Down-regulated in cervical cancer.
genes like me logo Genes that share expressions with ST20: view

Orthologs for ST20 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ST20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST20 36
  • 99.58 (n)
  • 98.73 (a)
ST20 37
  • 99 (a)
OneToOne
Species with no ortholog for ST20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ST20 Gene

ENSEMBL:
Gene Tree for ST20 (if available)
TreeFam:
Gene Tree for ST20 (if available)

Paralogs for ST20 Gene

No data available for Paralogs for ST20 Gene

Variants for ST20 Gene

Sequence variations from dbSNP and Humsavar for ST20 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs78645649 -- 79,925,500(+) CTTAG(C/T)TTCCT upstream-variant-2KB
rs144412038 -- 79,925,431(+) GTTCT(A/T)TTACA upstream-variant-2KB
rs146815544 -- 79,925,697(+) ATTAT(-/TTTG)TTTGT upstream-variant-2KB
rs149636034 -- 79,925,422(+) AGTGA(C/T)CCAGT upstream-variant-2KB
rs200208647 -- 79,925,369(+) GCTTC(A/G)GCCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ST20 Gene

Variant ID Type Subtype PubMed ID
nsv833065 CNV Loss 17160897
nsv833066 CNV Loss 17160897
esv2660680 CNV Deletion 23128226
nsv510406 CNV Loss 20534489
esv2672391 CNV Deletion 23128226
nsv904435 CNV Gain 21882294
dgv155n21 CNV Loss 19592680

Relevant External Links for ST20 Gene

HapMap Linkage Disequilibrium report
ST20

Disorders for ST20 Gene

(1) University of Copenhagen DISEASES for ST20 Gene

genes like me logo Genes that share disorders with ST20: view

No data available for UniProtKB/Swiss-Prot for ST20 Gene

Publications for ST20 Gene

  1. Candidate tumor suppressor, HCCS-1, is downregulated in human cancers and induces apoptosis in cervical cancer. (PMID: 11857354) Kim T.E. … Kim J.W. (Int. J. Cancer 2002) 3 4
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3
  3. Genome-wide association study of chronic periodontitis in a general German population. (PMID: 24024966) Teumer A. … Kocher T. (J. Clin. Periodontol. 2013) 3
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 4

Products for ST20 Gene

Sources for ST20 Gene

Back to Top

Content