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ST18 Gene(Protein Coding)

ST18, C2H2C-Type Zinc Finger

GCID:
GC08M052110
GIFtS:
46
Genes Participants
UDN Logo

Aliases for ST18 Gene

Aliases for ST18 Gene

  • ST18, C2H2C-Type Zinc Finger 2 3 5
  • Zinc Finger Protein 387 2 3 4
  • Suppression Of Tumorigenicity 18 (Breast Carcinoma) (Zinc Finger Protein) 2 3
  • Suppression Of Tumorigenicity 18, Zinc Finger 2 3
  • Neural Zinc Finger Transcription Factor 3 2 3
  • ZNF387 3 4
  • Suppression Of Tumorigenicity 18 Protein 3
  • KIAA0535 4
  • ZC2H2C3 3
  • ZC2HC10 3
  • NZF3 3

External Ids for ST18 Gene

Previous HGNC Symbols for ST18 Gene

  • ZNF387

Previous GeneCards Identifiers for ST18 Gene

  • GC08M053028
  • GC08M052746
  • GC08M053073
  • GC08M053185
  • GC08M048491
  • GC08M053023

Summaries for ST18 Gene

GeneCards Summary for ST18 Gene

ST18 (ST18, C2H2C-Type Zinc Finger) is a Protein Coding gene. Diseases associated with ST18 include Breast Cancer. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is MYT1.

UniProtKB/Swiss-Prot for ST18 Gene

  • Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5-AAAGTTT-3 separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells.

Additional gene information for ST18 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST18 Gene

Genomics for ST18 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for ST18 Gene

Promoters and enhancers for ST18 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH08I052460 Enhancer 0.8 Ensembl ENCODE 562.2 +0.3 322 1.1 SMARCC1 JUN USF2 MAX CEBPB EP300 JUND POLR2A FOS ST18 ALKAL1 GC08M052343
GH08I052409 Promoter/Enhancer 0.7 EPDnew dbSUPER 550.2 +51.2 51183 0.1 ST18 GC08M052343 GC08P052343
GH08I052329 Promoter 0.5 EPDnew 550.1 +131.7 131657 0.1 ST18 GC08M052338 RPL34P17
GH08I052459 Enhancer 0.2 FANTOM5 550.8 +1.2 1155 0.1 ST18 RB1CC1 GC08M052343
GH08I052466 Enhancer 1.4 FANTOM5 Ensembl ENCODE 12.9 -6.4 -6380 1.5 PKNOX1 CLOCK FOXA2 ZFP64 SIN3A BRCA1 GLIS2 FOS RUNX3 SMARCB1 ST18 ALKAL1 RB1CC1 GC08M052509
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ST18 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ST18 gene promoter:

Genomic Locations for ST18 Gene

Genomic Locations for ST18 Gene
chr8:52,110,832-52,460,959
(GRCh38/hg38)
Size:
350,128 bases
Orientation:
Minus strand
chr8:53,023,392-53,373,519
(GRCh37/hg19)

Genomic View for ST18 Gene

Genes around ST18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST18 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ST18 Gene

Proteins for ST18 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ST18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60284-ST18_HUMAN
    Recommended name:
    Suppression of tumorigenicity 18 protein
    Protein Accession:
    O60284
    Secondary Accessions:
    • Q17RY1

    Protein attributes for ST18 Gene

    Size:
    1047 amino acids
    Molecular mass:
    115155 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ST18 Gene

neXtProt entry for ST18 Gene

Protein Expression for ST18 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ST18 Gene

No Post-translational modifications

Other Protein References for ST18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ST18 Gene

Domains & Families for ST18 Gene

Gene Families for ST18 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ST18 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ST18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60284

UniProtKB/Swiss-Prot:

ST18_HUMAN :
  • Belongs to the MYT1 family.
Family:
  • Belongs to the MYT1 family.
genes like me logo Genes that share domains with ST18: view

Function for ST18 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ST18 Gene

UniProtKB/Swiss-Prot Function:
Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5-AAAGTTT-3 separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells.

Phenotypes From GWAS Catalog for ST18 Gene

Gene Ontology (GO) - Molecular Function for ST18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001047 core promoter binding IDA 18676404
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ST18: view
genes like me logo Genes that share phenotypes with ST18: view

Animal Models for ST18 Gene

MGI Knock Outs for ST18:
  • St18 tm1a(KOMP)Wtsi

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ST18 Gene

Localization for ST18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST18 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST18 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ST18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 15489893
GO:0032993 protein-DNA complex IDA 18676404
genes like me logo Genes that share ontologies with ST18: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ST18 Gene

Pathways & Interactions for ST18 Gene

SuperPathways for ST18 Gene

PathCards logo More details on SuperPathways for ST18
No Data Available

Interacting Proteins for ST18 Gene

Selected Interacting proteins: O60284-ST18_HUMAN for ST18 Gene via IID

Gene Ontology (GO) - Biological Process for ST18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008285 negative regulation of cell proliferation IDA 15489893
GO:0033209 tumor necrosis factor-mediated signaling pathway IMP 18676404
GO:0045944 positive regulation of transcription by RNA polymerase II IMP 18676404
genes like me logo Genes that share ontologies with ST18: view

No data available for Pathways by source and SIGNOR curated interactions for ST18 Gene

Drugs & Compounds for ST18 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ST18 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ST18 Gene

(110) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(76) Selected AceView cDNA sequences:
(24) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ST18 Gene

Suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST18 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b · 13c ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - - -
SP6:
SP7: - - - - - - - - - - - - - - - - -
SP8: - - - -
SP9:
SP10:
SP11:
SP12: - - - - - - - -
SP13: - - - - - - - - - -
SP14: - -
SP15: - - - - -
SP16: - - - -
SP17: -
SP18:
SP19: -

ExUns: 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c ^ 30 ^ 31 ^
SP1: - - - -
SP2: - -
SP3: -
SP4: -
SP5: -
SP6: -
SP7: -
SP8:
SP9:
SP10:
SP11: - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

ExUns: 32 ^ 33 ^ 34
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for ST18 Gene

GeneLoc Exon Structure for
ST18
ECgene alternative splicing isoforms for
ST18

Expression for ST18 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST18 Gene

mRNA expression in normal human tissues for ST18 Gene
mRNA expression by BioGPS for ST18 GenemRNA expression by GTEx for ST18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST18 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x11.2), Brain - Cerebellar Hemisphere (x8.4), Brain - Substantia nigra (x5.9), Brain - Cerebellum (x5.8), and Brain - Hippocampus (x4.0).

Protein differential expression in normal tissues from HIPED for ST18 Gene

This gene is overexpressed in Ovary (47.7), Pancreas (11.2), and Stomach (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ST18 Gene



Protein tissue co-expression partners for ST18 Gene

NURSA nuclear receptor signaling pathways regulating expression of ST18 Gene:

ST18

SOURCE GeneReport for Unigene cluster for ST18 Gene:

Hs.655499

mRNA Expression by UniProt/SwissProt for ST18 Gene:

O60284-ST18_HUMAN
Tissue specificity: Detected at low levels in heart, liver, kidney, skeletal muscle, pancreas, testis, ovary and prostate. Detected at even lower levels in mammary epithelial cells and breast cancer cells.

Evidence on tissue expression from TISSUES for ST18 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ST18: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ST18 Gene

Orthologs for ST18 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ST18 33 34
  • 99.46 (n)
dog
(Canis familiaris)
 Mammalia ST18 33 34
  • 91.88 (n)
rat
(Rattus norvegicus)
 Mammalia St18 33
  • 85.44 (n)
mouse
(Mus musculus)
 Mammalia St18 33 16 34
  • 85.36 (n)
cow
(Bos Taurus)
 Mammalia ST18 33 34
  • 85.07 (n)
oppossum
(Monodelphis domestica)
 Mammalia ST18 34
  • 79 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia ST18 34
  • 76 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves ST18 33 34
  • 80.01 (n)
lizard
(Anolis carolinensis)
 Reptilia ST18 34
  • 72 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia st18 33
  • 68.97 (n)
zebrafish
(Danio rerio)
 Actinopterygii st18 34
  • 60 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG43689 34
  • 9 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea ztf-11 34
  • 16 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 16 (a)
 OneToMany
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.9753 33
Species where no ortholog for ST18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ST18 Gene

ENSEMBL:
Gene Tree for ST18 (if available)
TreeFam:
Gene Tree for ST18 (if available)

Paralogs for ST18 Gene

Paralogs for ST18 Gene

(2) SIMAP similar genes for ST18 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ST18: view

Variants for ST18 Gene

Sequence variations from dbSNP and Humsavar for ST18 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000004585 -- 52,359,480(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000024418 -- 52,237,936(-) C/G intron_variant
rs1000053180 -- 52,147,263(-) A/G intron_variant
rs1000067850 -- 52,304,758(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000069019 -- 52,186,158(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ST18 Gene

Variant ID Type Subtype PubMed ID
dgv7218n100 CNV gain 25217958
esv2636600 CNV insertion 19546169
esv2761192 CNV gain 21179565
esv3306151 CNV mobile element insertion 20981092
esv3369035 CNV insertion 20981092
esv3375181 CNV insertion 20981092
esv3400120 CNV insertion 20981092
esv3572759 CNV loss 25503493
esv3617209 CNV loss 21293372
esv3617210 CNV gain 21293372
esv3617211 CNV gain 21293372
esv3891395 CNV gain 25118596
nsv1032281 CNV gain 25217958
nsv831317 CNV gain 17160897

Variation tolerance for ST18 Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.74; 66.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST18 Gene

Human Gene Mutation Database (HGMD)
ST18
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST18 Gene

Disorders for ST18 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ST18 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search ST18 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ST18

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ST18: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST18 Gene

Publications for ST18 Gene

  1. ST18 is a breast cancer tumor suppressor gene at human chromosome 8q11.2. (PMID: 15489893) Jandrig B … Rosenthal A (Oncogene 2004) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 58
  5. Identification of a Functional Risk Variant for Pemphigus Vulgaris in the ST18 Gene. (PMID: 27148741) Vodo D … Sprecher E (PLoS genetics 2016) 3 58

Products for ST18 Gene

Sources for ST18 Gene

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