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Aliases for ST18 Gene

Aliases for ST18 Gene

  • Suppression Of Tumorigenicity 18, Zinc Finger 2 3
  • Zinc Finger Protein 387 2 3 4
  • Suppression Of Tumorigenicity 18 (Breast Carcinoma) (Zinc Finger Protein) 2 3
  • Neural Zinc Finger Transcription Factor 3 2 3
  • ZNF387 3 4
  • Suppression Of Tumorigenicity 18 Protein 3
  • KIAA0535 4
  • ZC2HC10 3
  • NZF3 3

External Ids for ST18 Gene

Previous HGNC Symbols for ST18 Gene

  • ZNF387

Previous GeneCards Identifiers for ST18 Gene

  • GC08M053028
  • GC08M052746
  • GC08M053073
  • GC08M053185
  • GC08M048491
  • GC08M053023

Summaries for ST18 Gene

GeneCards Summary for ST18 Gene

ST18 (Suppression Of Tumorigenicity 18, Zinc Finger) is a Protein Coding gene. Diseases associated with ST18 include primary angle-closure glaucoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MYT1L.

UniProtKB/Swiss-Prot for ST18 Gene

  • Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5-AAAGTTT-3 separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST18 Gene

Genomics for ST18 Gene

Regulatory Elements for ST18 Gene

Genomic Location for ST18 Gene

Start:
52,110,832 bp from pter
End:
52,460,959 bp from pter
Size:
350,128 bases
Orientation:
Minus strand

Genomic View for ST18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ST18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST18 Gene

Proteins for ST18 Gene

  • Protein details for ST18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60284-ST18_HUMAN
    Recommended name:
    Suppression of tumorigenicity 18 protein
    Protein Accession:
    O60284
    Secondary Accessions:
    • Q17RY1

    Protein attributes for ST18 Gene

    Size:
    1047 amino acids
    Molecular mass:
    115155 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ST18 Gene

neXtProt entry for ST18 Gene

Proteomics data for ST18 Gene at MOPED

Post-translational modifications for ST18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ST18 Gene

No data available for DME Specific Peptides for ST18 Gene

Domains for ST18 Gene

Gene Families for ST18 Gene

HGNC:
  • ZC2HC :Zinc fingers, C2HC-type containing

Protein Domains for ST18 Gene

Suggested Antigen Peptide Sequences for ST18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60284

UniProtKB/Swiss-Prot:

ST18_HUMAN :
  • O60284
Similarity:
  • Contains 6 C2HC-type zinc fingers.
genes like me logo Genes that share domains with ST18: view

Function for ST18 Gene

Molecular function for ST18 Gene

UniProtKB/Swiss-Prot Function: Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5-AAAGTTT-3 separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells.

Gene Ontology (GO) - Molecular Function for ST18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ST18: view

Phenotypes for ST18 Gene

MGI mutant phenotypes for ST18:
inferred from 1 alleles
GenomeRNAi human phenotypes for ST18:
genes like me logo Genes that share phenotypes with ST18: view

miRNA for ST18 Gene

miRTarBase miRNAs that target ST18

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ST18 Gene

Localization for ST18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST18 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST18 Gene COMPARTMENTS Subcellular localization image for ST18 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ST18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ST18: view

Pathways for ST18 Gene

SuperPathways for ST18 Gene

No Data Available

Interacting Proteins for ST18 Gene

Selected Interacting proteins: O60284-ST18_HUMAN for ST18 Gene via I2D

Symbol External ID(s) Details
PSMC5

Gene Ontology (GO) - Biological Process for ST18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ST18: view

No data available for Pathways by source for ST18 Gene

Transcripts for ST18 Gene

Unigene Clusters for ST18 Gene

Suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ST18 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b · 13c ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - - -
SP6:
SP7: - - - - - - - - - - - - - - - - -
SP8: - - - -
SP9:
SP10:
SP11:
SP12: - - - - - - - -
SP13: - - - - - - - - - -
SP14: - -
SP15: - - - - -
SP16: - - - -
SP17: -
SP18:
SP19: -

ExUns: 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c ^ 30 ^ 31 ^
SP1: - - - -
SP2: - -
SP3: -
SP4: -
SP5: -
SP6: -
SP7: -
SP8:
SP9:
SP10:
SP11: - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

ExUns: 32 ^ 33 ^ 34
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for ST18 Gene

GeneLoc Exon Structure for
ST18
ECgene alternative splicing isoforms for
ST18

Expression for ST18 Gene

mRNA expression in normal human tissues for ST18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST18 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (11.2), Brain - Cerebellar Hemisphere (8.4), Brain - Substantia nigra (5.9), Brain - Cerebellum (5.8), and Brain - Hippocampus (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ST18 Gene

SOURCE GeneReport for Unigene cluster for ST18 Gene Hs.655499

mRNA Expression by UniProt/SwissProt for ST18 Gene

O60284-ST18_HUMAN
Tissue specificity: Detected at low levels in heart, liver, kidney, skeletal muscle, pancreas, testis, ovary and prostate. Detected at even lower levels in mammary epithelial cells and breast cancer cells.
genes like me logo Genes that share expressions with ST18: view

Orthologs for ST18 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST18 35
  • 99.46 (n)
  • 99.52 (a)
ST18 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ST18 35
  • 85.07 (n)
  • 88.13 (a)
ST18 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ST18 35
  • 91.88 (n)
  • 93.12 (a)
ST18 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St18 35
  • 85.36 (n)
  • 85.07 (a)
St18 16
St18 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ST18 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ST18 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia St18 35
  • 85.44 (n)
  • 86.11 (a)
chicken
(Gallus gallus)
Aves ST18 35
  • 80.01 (n)
  • 81 (a)
ST18 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST18 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st18 35
  • 68.97 (n)
  • 67.26 (a)
zebrafish
(Danio rerio)
Actinopterygii st18 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG43689 36
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ztf-11 36
  • 16 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9753 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
OneToMany
Species with no ortholog for ST18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ST18 Gene

ENSEMBL:
Gene Tree for ST18 (if available)
TreeFam:
Gene Tree for ST18 (if available)

Paralogs for ST18 Gene

Paralogs for ST18 Gene

Selected SIMAP similar genes for ST18 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ST18: view

Variants for ST18 Gene

Sequence variations from dbSNP and Humsavar for ST18 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs714048 -- 52,273,158(+) ACATC(A/C)CATCC intron-variant
rs724112 -- 52,131,787(-) GAAAA(A/C)TGTTA intron-variant
rs753019 -- 52,240,482(-) CCTGT(A/T)AAACC intron-variant
rs755540 -- 52,225,189(-) CTTGC(A/G)TAAGT intron-variant
rs755541 -- 52,225,166(-) TTCAG(A/G)GCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST18 Gene

Variant ID Type Subtype PubMed ID
esv270428 CNV Insertion 20981092
esv2636600 CNV Insertion 19546169
nsv831317 CNV Gain 17160897
dgv7794n71 CNV Gain 21882294

Relevant External Links for ST18 Gene

HapMap Linkage Disequilibrium report
ST18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST18 Gene

Disorders for ST18 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ST18 Gene including...

Search for ST18 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ST18 Gene

Relevant External Links for ST18

Genetic Association Database (GAD)
ST18
Human Genome Epidemiology (HuGE) Navigator
ST18
genes like me logo Genes that share disorders with ST18: view

No data available for UniProtKB/Swiss-Prot for ST18 Gene

Publications for ST18 Gene

  1. ST18 is a breast cancer tumor suppressor gene at human chromosome 8q11.2. (PMID: 15489893) Jandrig B. … Rosenthal A. (Oncogene 2004) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Population-specific association between a polymorphic variant in ST18, encoding a pro-apoptotic molecule, and pemphigus vulgaris. (PMID: 22437316) Sarig O. … Sprecher E. (J. Invest. Dermatol. 2012) 3

Products for ST18 Gene

Sources for ST18 Gene

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