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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ST18 Gene

protein-coding   GIFtS: 54
GCID: GC08M053073

Suppression Of Tumorigenicity 18 (Breast Carcinoma) (Zinc...

(Previous name: zinc finger protein 387)
(Previous symbol: ZNF387)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Suppression Of Tumorigenicity 18 (Breast Carcinoma) (Zinc Finger
Protein)1 2
Zinc Finger Protein 3871 2 3
ZNF3871 2 3
ZC2HC102
Suppression Of Tumorigenicity 18 Protein2
KIAA05353

External Ids:    HGNC: 186951   Entrez Gene: 97052   Ensembl: ENSG000001474887   UniProtKB: O602843   

Export aliases for ST18 gene to outside databases

Previous GC identifers: GC08M053028 GC08M052746 GC08M053185 GC08M048491


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ST18 Gene: 
ST18 (suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)) is a protein-coding gene. Diseases associated with ST18 include facial paralysis, and primary angle-closure glaucoma. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MYT1L.

UniProtKB/Swiss-Prot: ST18_HUMAN, O60284
Function: Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of
the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target
promoters (By similarity). Inhibits colony formation in cultured breast cancer cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008183.19  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ST18 gene promoter:
         C/EBPbeta   CUTL1   Nkx2-5   NF-AT   NF-AT4   NF-AT2   POU2F1   POU2F1a   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ST18 promoter sequence
   Search SABiosciences Chromatin IP Primers for ST18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q11.23   Ensembl cytogenetic band:  8q11.23   HGNC cytogenetic band: 8q11.23

ST18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST18 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M053073:  view genomic region     (about GC identifiers)

Start:
53,023,392 bp from pter      End:
53,373,519 bp from pter
Size:
350,128 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ST18_HUMAN, O60284 (See protein sequence)
Recommended Name: Suppression of tumorigenicity 18 protein  
Size: 1047 amino acids; 115155 Da
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for ST18:
2CS8 (3D)    
Secondary accessions: Q17RY1

Explore the universe of human proteins at neXtProt for ST18: NX_O60284

Explore proteomics data for ST18 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60284

  • ST18 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ST18 Protein Expression
    REFSEQ proteins: NP_055497.1  
    ENSEMBL proteins: 
     ENSP00000276480   ENSP00000429579   ENSP00000428920   ENSP00000430763   ENSP00000428521  
     ENSP00000428096  

    Human Recombinant Protein Products for ST18: 
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    OriGene Protein Over-expression Lysate for ST18
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ST18
    GenScript Custom Purified and Recombinant Proteins Services for ST18
    Novus Biologicals ST18 Protein
    Novus Biologicals ST18 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ST18 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ST18 for ontologies           About GeneDecksing



    ST18 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for ST18 

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    Cloud-Clone Corp. ELISAs for ST18 
    Cloud-Clone Corp. CLIAs for ST18


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZC2HC: Zinc fingers, C2HC-type containing

    2 InterPro protein domains:
     IPR002515 Znf_C2HC
     IPR013681 Myelin_TF

    Graphical View of Domain Structure for InterPro Entry O60284

    ProtoNet protein and cluster: O60284

    1 Blocks protein domain: IPB013681 Myelin transcription factor 1

    UniProtKB/Swiss-Prot: ST18_HUMAN, O60284
    Similarity: Contains 6 C2HC-type zinc fingers


    ST18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST18_HUMAN, O60284
    Function: Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of
    the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target
    promoters (By similarity). Inhibits colony formation in cultured breast cancer cells

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding IEA--
         
    ST18 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ST18:
     Synthetic lethal with c-Myc af 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for St18):
     homeostasis/metabolism 

    ST18 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ST18 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ST18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ST18 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ST18 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST18
    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate ST18 (see all 54):
    hsa-miR-3685 hsa-miR-323-3p hsa-miR-4317 hsa-miR-300 hsa-miR-875-5p hsa-let-7a-2* hsa-miR-301a hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidST18 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST18

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of ST18

    Clone
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    GenScript: all cDNA clones in your preferred vector: ST18 (NM_014682)
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                         Customized lentivirus expression plasmids for stable overexpression of ST18 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ST18
    Search LifeMap BioReagents cell lines for ST18
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST18


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ST18

    1 Interacting protein for ST18 (O602843) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMC5P621953I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----

    ST18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ST18

    Search CenterWatch for drugs/clinical trials and news about ST18

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ST18 gene: 
    NM_014682.2  

    Unigene Cluster for ST18:

    Suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)
    Hs.655499  [show with all ESTs]
    Unigene Representative Sequence: NM_014682
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000276480(uc011ldq.1 uc011ldr.1 uc003xqz.2 uc011lds.1 uc003xra.2 uc003xrb.2)
    ENST00000521824 ENST00000522251 ENST00000521582 ENST00000518053 ENST00000522861
    ENST00000518501 ENST00000517580 ENST00000520257 ENST00000521549(uc010lyb.2)
    ENST00000518037 ENST00000517456 ENST00000519118 ENST00000518545 ENST00000521119
    ENST00000518453 ENST00000520279 ENST00000519201
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST18
    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate ST18 (see all 54):
    hsa-miR-3685 hsa-miR-323-3p hsa-miR-4317 hsa-miR-300 hsa-miR-875-5p hsa-let-7a-2* hsa-miR-301a hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidST18 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ST18
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST18
    Clone
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    OriGene clones in human, mouse for ST18 (see all 7)
    OriGene ORF clones in mouse, rat for ST18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ST18 (NM_014682)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST18
    Sirion Biotech Customized lentivirus for stable overexpression of ST18 
                         Customized lentivirus expression plasmids for stable overexpression of ST18 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ST18
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ST18
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ST18
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST18

    Additional mRNA sequence: 

    AB011107.1 AK311188.1 BC025662.1 BC026316.1 BC031075.1 BC117147.1 BC117149.1 BC143871.1 
    BC143872.1 BC143873.1 BC143875.1 

    10 DOTS entries:

    DT.412961  DT.92036482  DT.40253060  DT.97834849  DT.91747483  DT.95179296  DT.91892517  DT.120635610 
    DT.120635615  DT.97764366 

    24/76 AceView cDNA sequences (see all 76):

    BX282064 BP362876 BX642514 BE670703 AI298474 AI350226 BQ953938 AI298782 
    BG216577 BX953856 AB011107 NM_014682 BG218123 AA102556 AI741795 BG149419 
    BQ013076 CF529426 CB989836 BQ011733 BC025662 BC026316 AW770749 CB989259 

    GeneLoc Exon Structure

    5/19 Alternative Splicing Database (ASD) splice patterns (SP) for ST18 (see all 19)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b · 13c ^
    SP1:                                      -           -     -     -     -     -     -     -     -           -     -                       -                     
    SP2:                                      -           -     -     -     -     -     -     -     -           -     -                       -                     
    SP3:                                                                                                        -     -                       -                     
    SP4:                                                                                                        -     -                       -           -     -   
    SP5:                                                                                                        -     -                       -     -     -     -   

    ExUns: 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c ^ 30 ^ 31 ^
    SP1:                          -                                                                       -                 -           -                           
    SP2:  -                       -                                                                                                                                 
    SP3:  -                                                                                                                                                         
    SP4:  -                                                                                                                                                         
    SP5:  -                                                                                                                                                         

    ExUns: 32 ^ 33 ^ 34
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for ST18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ST18 expression in normal human tissues (normalized intensities)      ST18 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACTTTGGT
    ST18 Expression
    About this image


    ST18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 4 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
     
     Brain (Nervous System)    fully expand to see all 4 entries
             corpus callosum   
     
     Bone (Muscoskeletal System)
             Zeugopod Periosteum
     
     Head Mesenchyme (Muscoskeletal System)
             Frontonasal Process
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer

    See ST18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ST18

    SOURCE GeneReport for Unigene cluster: Hs.655499

    UniProtKB/Swiss-Prot: ST18_HUMAN, O60284
    Tissue specificity: Detected at low levels in heart, liver, kidney, skeletal muscle, pancreas, testis, ovary and
    prostate. Detected at even lower levels in mammary epithelial cells and breast cancer cells

        SABiosciences Custom PCR Arrays for ST18
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST18
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ST18 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St181 , 5 suppression of tumorigenicity 181, 5 85.36(n)1
    85.07(a)1
      1 (1.89 cM)5
    2406901  NM_001244692.11  NP_001231621.11 
     64872315 
    chicken
    (Gallus gallus)
    Aves ST181 suppression of tumorigenicity 18 (breast carcinoma) more 79.66(n)
    80.46(a)
      421115  XM_419199.2  XP_419199.2 
    lizard
    (Anolis carolinensis)
    Reptilia ST186
    suppression of tumorigenicity 18 (breast carcinoma...
    73(a)
    1 ↔ 1
    GL343244.1(1850523-2098155)
    zebrafish
    (Danio rerio)
    Actinopterygii st186
    suppression of tumorigenicity 18 (breast carcinoma...
    59(a)
    1 ↔ 1
    24(36615702-36657091)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG436896
    --
    10(a)
    possible ortholog
    X(3970107-3986186)


    ENSEMBL Gene Tree for ST18 (if available)
    TreeFam Gene Tree for ST18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ST18 gene
    MYT1L2  MYT12  
    2 SIMAP similar genes for ST18 using alignment to 7 protein entries:     ST18_HUMAN (see all proteins):
    MYT1    MYT1L

    ST18 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5772 SNPs in ST18 are shown (see all 5772)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901744601,2
    C--53023051(+) TATACC/TCCGTA 1 -- ds50010--------
    rs1485358461,2
    C--53023053(+) TACTCC/TGTATC 1 -- ds50010--------
    rs625009721,2
    C,F--53023095(+) CTCTAT/CCTTGC 1 -- ds50016Minor allele frequency- C:0.25NA CSA WA EA 364
    rs1931270821,2
    --53023154(+) CCTTAC/TGTCAA 1 -- ds50010--------
    rs1418151911,2
    --53023225(+) CAAAAA/GTCCTG 1 -- ds50010--------
    rs1846874391,2
    --53023276(+) GTCTCC/TGAATG 1 -- ds50010--------
    rs1174667011,2
    C,F--53023279(+) TCCGAA/GTGACT 1 -- ds50011Minor allele frequency- G:0.03NA 120
    rs1506136671,2
    --53023307(+) TCTGGG/TGACCT 1 -- ds50010--------
    rs69949151,2
    C,F,H--53023384(+) AGAAAG/AATCAC 1 -- ds50019Minor allele frequency- A:0.01NS NA 1164
    rs1883080141,2
    --53023389(+) GATCAA/CATCAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ST18 (53023392 - 53273392 bp, first 250kb of ST18)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ST18:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv270428CNV Insertion20981092
    esv2636600CNV Insertion19546169
    dgv7794n71CNV Gain21882294
    nsv831317CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    9 diseases for ST18:    About MalaCards
    facial paralysis    primary angle-closure glaucoma    paralysis    pemphigus vulgaris
    pemphigus    glaucoma    retinitis    breast cancer
    prostatitis

    1 disease from the University of Copenhagen DISEASES database for ST18:
    Primary angle-closure glaucoma

    ST18 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ST18
    Human Genome Epidemiology (HuGE) Navigator: ST18 (1 document)

    Export disorders for ST18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ST18 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with ST18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ST18 is a breast cancer tumor suppressor gene at human chromosome 8q11.2. (PubMed id 15489893)1, 2, 3, 9 Jandrig B....Rosenthal A. (2004)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (1998)
    5. Genotype-phenotype analysis of SNPs associated with pr imary angle closure glaucoma (rs1015213, rs3753841 and rs11024102) and ocular bi ometry in the EPIC-Norfolk Eye Study. (PubMed id 23505305)1 Day A.C....Foster P.J. (2013)
    6. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PubMed id 23535033)1 Sherva R....Green R.C. (2013)
    7. Population-specific association between a polymorphic variant in ST18, encoding a pro-apoptotic molecule, and pemphigus vulgaris. (PubMed id 22437316)1 Sarig O....Sprecher E. (2012)
    8. The transcription factor ST18 regulates proapoptotic and proinflammatory gene expression in fibroblasts. (PubMed id 18676404)1 Yang J....Graves D.T. (2008)
    9. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (2007)
    10. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9705 HGNC: 18695 AceView: ST18 Ensembl:ENSG00000147488 euGenes: HUgn9705
    ECgene: ST18 H-InvDB: ST18

    (According to HUGE)
    About This Section
    HUGE: KIAA0535

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ST18 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ST18 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ST18 gene:
    Search GeneIP for patents involving ST18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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