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ST18 Gene

protein-coding GIFtS: 55
GCID: GC08M053023

Suppression Of Tumorigenicity 18, Zinc Finger

(Previous names: zinc finger protein 387, suppression of tumorigenicity 18...)
(Previous symbol: ZNF387)

See ST18-related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Suppression Of Tumorigenicity 18, Zinc Finger¹ ²		NZF3²
Zinc Finger Protein 387¹ ² ³		ZC2HC10²
ZNF387¹ ² ³		Suppression Of Tumorigenicity 18 Protein²
Suppression Of Tumorigenicity 18 (Breast Carcinoma) (Zinc Finger Protein)¹ ²		KIAA0535³
Neural Zinc Finger Transcription Factor 3¹ ²

External Ids:	HGNC: 18695¹	Entrez Gene: 9705²	Ensembl: ENSG00000147488⁷	UniProtKB: O60284³

ORGUL members:

Export aliases for ST18 gene to outside databases

Previous GC identifers: GC08M053028 GC08M052746 GC08M053073 GC08M053185 GC08M048491

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ST18 Gene:

ST18 (suppression of tumorigenicity 18, zinc finger) is a protein-coding gene. Diseases associated with ST18 include primary angle-closure glaucoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MYT1L.

UniProtKB/Swiss-Prot: ST18_HUMAN, O60284

Function: Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of

the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target

promoters (By similarity). Inhibits colony formation in cultured breast cancer cells

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000008.10 NT_008183.20 NC_018919.2

Regulatory elements:

Regulatory transcription factor binding sites in the ST18 gene promoter:
C/EBPbeta CUTL1 Nkx2-5 NF-AT NF-AT4 NF-AT2 POU2F1 POU2F1a NF-AT3 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ST18 promoter sequence

Search Chromatin IP Primers for ST18

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST18

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q11.23 Ensembl cytogenetic band: 8q11.23 HGNC cytogenetic band: 8q11.23

ST18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST18 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M053023: view genomic region (about GC identifiers)

Start:	53,023,392 bp from pter	End:	53,373,519 bp from pter
Size:	350,128 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: ST18_HUMAN, O60284 (See protein sequence)

Recommended Name: Suppression of tumorigenicity 18 protein

Size: 1047 amino acids; 115155 Da

1 PDB 3D structure from and Proteopedia for ST18:

2CS8 (3D)

Secondary accessions: Q17RY1

Explore the universe of human proteins at neXtProt for ST18: NX_O60284

Explore proteomics data for ST18 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See ST18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_055497.1

ENSEMBL proteins:

ENSP00000276480 ENSP00000429579 ENSP00000428920 ENSP00000430763 ENSP00000428521

ENSP00000428096

ST18 Human Recombinant Protein Products:

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	antibodies-online peptides for ST18

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ST18 Assay Products:

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	antibodies-online kits for ST18 (6 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:

ZC2HC: Zinc fingers, C2HC-type containing

2 InterPro protein domains:

IPR002515 Znf_C2HC

IPR013681 Myelin_TF

Graphical View of Domain Structure for InterPro Entry O60284

ProtoNet protein and cluster: O60284

1 Blocks protein domain: IPB013681 Myelin transcription factor 1

UniProtKB/Swiss-Prot: ST18_HUMAN, O60284

Similarity: Contains 6 C2HC-type zinc fingers

Find genes that share domains with ST18 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ST18_HUMAN, O60284

Function: Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of

the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target

promoters (By similarity). Inhibits colony formation in cultured breast cancer cells

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0008270	zinc ion binding	IEA	--

Find genes that share ontologies with ST18 About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for ST18:

Synthetic lethal with c-Myc af

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for St18):

homeostasis/metabolism

Find genes that share phenotypes with ST18 About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for ST18

miRNA Products:		miRTarBase miRNAs that target ST18: hsa-mir-26b-5p (MIRT030273)

		Block miRNA regulation of human, mouse, rat ST18 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate ST18 (see all 54):
		hsa-miR-3685 hsa-miR-323-3p hsa-miR-4317 hsa-miR-300 hsa-miR-875-5p hsa-let-7a-2* hsa-miR-301a hsa-miR-138-2*

		SwitchGear 3'UTR luciferase reporter plasmid: ST18 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST18

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

ST18_HUMAN, O60284: Nucleus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
cytosol	2

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

Find genes that share ontologies with ST18 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for ST18
Interactions:

Search GeneGlobe Interaction Network for ST18

1 Interacting protein for ST18 (O60284³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PSMC5	P62195³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-templated	IEA	--
GO:0006355	regulation of transcription, DNA-templated	--	--

Find genes that share ontologies with ST18 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for ST18

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for ST18 gene (5 alternative transcripts):

NM_014682.2 XM_006716487.1 XM_006716488.1 XM_006716489.1 XM_006716490.1

Unigene Cluster for ST18:

Suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)

Hs.655499 [show with all ESTs]

Unigene Representative Sequence: NM_014682

Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):

ENST00000276480(uc011ldq.1 uc011ldr.1 uc003xqz.2 uc011lds.1 uc003xra.2 uc003xrb.2)

ENST00000521824 ENST00000522251 ENST00000521582 ENST00000518053 ENST00000522861

ENST00000518501 ENST00000517580 ENST00000520257 ENST00000521549(uc010lyb.2)

ENST00000518037 ENST00000517456 ENST00000519118 ENST00000518545 ENST00000521119

ENST00000518453 ENST00000520279 ENST00000519201

miRNA Products:		Block miRNA regulation of human, mouse, rat ST18 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate ST18 (see all 54):
		hsa-miR-3685 hsa-miR-323-3p hsa-miR-4317 hsa-miR-300 hsa-miR-875-5p hsa-let-7a-2* hsa-miR-301a hsa-miR-138-2*

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Additional mRNA sequence:

AB011107.1 AK311188.1 BC025662.1 BC026316.1 BC031075.1 BC117147.1 BC117149.1 BC143871.1

BC143872.1 BC143873.1 BC143875.1

10 DOTS entries:

DT.412961 DT.92036482 DT.40253060 DT.97834849 DT.91747483 DT.95179296 DT.91892517 DT.120635610

DT.120635615 DT.97764366

Selected AceView cDNA sequences (see all 76):

AB011107 AI298474 AI298782 BE670703 BX282064 AI350226 BQ953938 BG218123

AI741795 AA102556 BX953856 BG216577 NM_014682 BP362876 BX642514 AI458365

BI600398 CA943336 CF994459 CB989836 BV206022 BF110433 BE465392 BE550737

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for ST18 (see all 19) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	·	11c	^	12a	·	12b	^	13a	·	13b	·	13c	^
SP1:													-				-		-		-		-		-		-		-		-				-		-								-
SP2:													-				-		-		-		-		-		-		-		-				-		-								-
SP3:																																			-		-								-
SP4:																																			-		-								-				-		-
SP5:																																			-		-								-		-		-		-

ExUns:	14a	·	14b	·	14c	^	15	^	16	^	17	^	18a	·	18b	^	19	^	20	^	21	^	22	^	23	^	24a	·	24b	^	25	^	26a	·	26b	^	27	^	28a	·	28b	^	29a	·	29b	·	29c	^	30	^	31	^
SP1:									-																								-						-				-
SP2:	-								-
SP3:	-
SP4:	-
SP5:	-

ExUns:	32	^	33	^	34
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ST18

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ST18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAACTTTGGT

About this image

ST18 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 10) fully expand


Pancreas (Endocrine System) fully expand to see all 4 entries
Endocrine Progenitor Cells Ventral Pancreatic Bud

Bone (Muscoskeletal System)
Zeugopod Periosteum

Neural Tube (Nervous System)
Telencephalon

Head Mesenchyme (Muscoskeletal System)
Frontonasal Process

Eye (Sensory Organs)
nGnG Amacrine Cells Inner Nuclear Layer

ST18 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ST18 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.655499

UniProtKB/Swiss-Prot: ST18_HUMAN, O60284

Tissue specificity: Detected at low levels in heart, liver, kidney, skeletal muscle, pancreas, testis, ovary and

prostate. Detected at even lower levels in mammary epithelial cells and breast cancer cells

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ST18 gene from Selected species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	St18^{1 , 5}	suppression of tumorigenicity 18^{1, 5}	85.36(n)¹ 85.07(a)¹		1 (1.89 cM)⁵ 240690¹ NM_001244692.1¹ NP_001231621.1¹ 6487231⁵
chicken (Gallus gallus)	Aves	ST18¹	suppression of tumorigenicity 18 (breast carcinoma) more	80.01(n) 81(a)		421115 XM_419199.3 XP_419199.3
lizard (Anolis carolinensis)	Reptilia	ST18⁶	suppression of tumorigenicity 18 (breast carcinoma...	72(a)	1 ↔ 1	GL343244.1(1850523-2098155)
tropical clawed frog (Xenopus tropicalis)	Amphibia	st18¹	suppression of tumorigenicity 18 (breast carcinoma) more	68.97(n) 67.26(a)		100489306 XM_002934112.2 XP_002934158.1
zebrafish (Danio rerio)	Actinopterygii	st18⁶	suppression of tumorigenicity 18 (breast carcinoma...	60(a)	1 ↔ 1	24(36615702-36657091) ENSDARG00000091410
fruit fly (Drosophila melanogaster)	Insecta	CG43689⁶	--	9(a)	1 → many	X(3970107-3986186)
worm (Caenorhabditis elegans)	Secernentea	ztf-11⁶	Protein ZTF-11, isoform b (ztf-11) mRNA, complete ...	16(a)	1 → many	I(9902943-9910545) WBGene00009939

ENSEMBL Gene Tree for ST18 (if available)
TreeFam Gene Tree for ST18 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for ST18 gene

MYT1L² MYT1²

2 SIMAP similar genes for ST18 using alignment to 7 protein entries: ST18_HUMAN (see all proteins):

MYT1 MYT1L

Find genes that share paralogs with ST18 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190174460^1,2	C	--	53023051(+)	`TATACC/TCCGTA`	1	--	ds500¹		0	--	--	--	--
rs148535846^1,2	C	--	53023053(+)	`TACTCC/TGTATC`	1	--	ds500¹		0	--	--	--	--
rs62500972^1,2	C,F	--	53023095(+)	`CTCTAT/CCTTGC`	1	--	ds500¹		6		NA CSA WA EA	364
rs193127082^1,2		--	53023154(+)	`CCTTAC/TGTCAA`	1	--	ds500¹		0	--	--	--	--
rs141815191^1,2		--	53023225(+)	`CAAAAA/GTCCTG`	1	--	ds500¹		0	--	--	--	--
rs184687439^1,2		--	53023276(+)	`GTCTCC/TGAATG`	1	--	ds500¹		0	--	--	--	--
rs117466701^1,2	C,F	--	53023279(+)	`TCCGAA/GTGACT`	1	--	ds500¹		1		NA	120
rs150613667^1,2		--	53023307(+)	`TCTGGG/TGACCT`	1	--	ds500¹		0	--	--	--	--
rs6994915^1,2	C,F,H	--	53023384(+)	`AGAAAG/AATCAC`	1	--	ds500¹		9		NS NA	1164
rs188308014^1,2		--	53023389(+)	`GATCAA/CATCAA`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ST18 (53023392 - 53273392 bp, first 250kb of ST18)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for ST18: About this table

Variant ID	Type	Subtype	PubMed ID
esv270428	CNV	Insertion	20981092
esv2636600	CNV	Insertion	19546169
dgv7794n71	CNV	Gain	21882294
nsv831317	CNV	Gain	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ST18

DNA2.0 Custom Variant and Variant Library Synthesis for ST18

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

1 disease for ST18:
About MalaCards

primary angle-closure glaucoma

1 inferred disease relationship from the University of Copenhagen DISEASES database for ST18:

Primary angle-closure glaucoma

Find genes that share disorders with ST18 About GenesLikeMe

Genetic Association Database (GAD): ST18
Human Genome Epidemiology (HuGE) Navigator: ST18 (1 document)

Export disorders for ST18 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ST18 gene, integrated from 10 sources (see all 14):
(articles sorted by number of sources associating them with ST18)

ST18 is a breast cancer tumor suppressor gene at human chromosome 8q11.2. (PubMed id 15489893)^{1, 2, 3, 9} Jandrig B....Rosenthal A. (Oncogene 2004)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)^{1, 2} Nagase T....Ohara O. (DNA Res. 1998)
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PubMed id 23535033)¹ Sherva R....Green R.C. (amp 2014)
Association study in a South Indian population supports rs1015213 as a risk factor for primary angle closure. (PubMed id 23847314)¹ Duvesh R....Sundaresan P. (amp 2013)
Genotype-phenotype analysis of SNPs associated with primary angle closure glaucoma (rs1015213, rs3753841 and rs11024102) and ocular biometry in the EPIC-Norfolk Eye Study. (PubMed id 23505305)¹ Day A.C....Foster P.J. (Br J Ophthalmol 2013)
Population-specific association between a polymorphic variant in ST18, encoding a pro-apoptotic molecule, and pemphigus vulgaris. (PubMed id 22437316)¹ Sarig O....Sprecher E. (J. Invest. Dermatol. 2012)
The transcription factor ST18 regulates proapoptotic and proinflammatory gene expression in fibroblasts. (PubMed id 18676404)¹ Yang J....Graves D.T. (FASEB J. 2008)
Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)⁴ Kiel D.P....Karasik D. (BMC Med. Genet. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9705	HGNC: 18695	AceView: ST18	Ensembl:ENSG00000147488	euGenes: HUgn9705
ECgene: ST18	H-InvDB: ST18

(According to HUGE)
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HUGE: KIAA0535

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ST18	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ST18	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ST18 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ST18 gene:
Search GeneIP for patents involving ST18

GeneCards and IP:
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ST18 Gene

Suppression Of Tumorigenicity 18, Zinc Finger

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