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ST18 Gene

protein-coding   GIFtS: 55
GCID: GC08M053023

Suppression Of Tumorigenicity 18, Zinc Finger

(Previous names: zinc finger protein 387, suppression of tumorigenicity 18...)
(Previous symbol: ZNF387)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Suppression Of Tumorigenicity 18, Zinc Finger1 2     NZF32
Zinc Finger Protein 3871 2 3     ZC2HC102
ZNF3871 2 3     Suppression Of Tumorigenicity 18 Protein2
Suppression Of Tumorigenicity 18 (Breast Carcinoma) (Zinc Finger Protein)1 2     KIAA05353
Neural Zinc Finger Transcription Factor 31 2     

External Ids:    HGNC: 186951   Entrez Gene: 97052   Ensembl: ENSG000001474887   UniProtKB: O602843   
ORGUL members:         

Export aliases for ST18 gene to outside databases

Previous GC identifers: GC08M053028 GC08M052746 GC08M053073 GC08M053185 GC08M048491


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ST18 Gene:
ST18 (suppression of tumorigenicity 18, zinc finger) is a protein-coding gene. Diseases associated with ST18 include facial paralysis, and primary angle-closure glaucoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MYT1L.

UniProtKB/Swiss-Prot: ST18_HUMAN, O60284
Function: Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of
the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target
promoters (By similarity). Inhibits colony formation in cultured breast cancer cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_008183.20  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ST18 gene promoter:
         C/EBPbeta   CUTL1   Nkx2-5   NF-AT   NF-AT4   NF-AT2   POU2F1   POU2F1a   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ST18 promoter sequence
   Search Chromatin IP Primers for ST18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q11.23   Ensembl cytogenetic band:  8q11.23   HGNC cytogenetic band: 8q11.23

ST18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST18 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M053023:  view genomic region     (about GC identifiers)

Start:
53,023,392 bp from pter      End:
53,373,519 bp from pter
Size:
350,128 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ST18_HUMAN, O60284 (See protein sequence)
Recommended Name: Suppression of tumorigenicity 18 protein  
Size: 1047 amino acids; 115155 Da
1 PDB 3D structure from and Proteopedia for ST18:
2CS8 (3D)    
Secondary accessions: Q17RY1

Explore the universe of human proteins at neXtProt for ST18: NX_O60284

Explore proteomics data for ST18 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ST18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055497.1  
    ENSEMBL proteins: 
     ENSP00000276480   ENSP00000429579   ENSP00000428920   ENSP00000430763   ENSP00000428521  
     ENSP00000428096  

    ST18 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ST18
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ST18
    GenScript Custom Purified and Recombinant Proteins Services for ST18
    Novus Biologicals ST18 Protein
    Novus Biologicals ST18 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ST18

    ST18 Antibody Products:

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    Abcam antibodies for ST18
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    LSBio Antibodies in human, mouse, rat for ST18

    ST18 Assay Products:

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    Cloud-Clone Corp. ELISAs for ST18
    Cloud-Clone Corp. CLIAs for ST18


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZC2HC: Zinc fingers, C2HC-type containing

    2 InterPro protein domains:
     IPR002515 Znf_C2HC
     IPR013681 Myelin_TF

    Graphical View of Domain Structure for InterPro Entry O60284

    ProtoNet protein and cluster: O60284

    1 Blocks protein domain: IPB013681 Myelin transcription factor 1

    UniProtKB/Swiss-Prot: ST18_HUMAN, O60284
    Similarity: Contains 6 C2HC-type zinc fingers


    ST18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST18_HUMAN, O60284
    Function: Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of
    the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target
    promoters (By similarity). Inhibits colony formation in cultured breast cancer cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding IEA--
         
    ST18 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ST18:
     Synthetic lethal with c-Myc af 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for St18):
     homeostasis/metabolism 

    ST18 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ST18
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ST18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ST18
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ST18

    miRNA
    Products:
        
    miRTarBase miRNAs that target ST18:
    hsa-mir-26b-5p (MIRT030273)

    Block miRNA regulation of human, mouse, rat ST18 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ST18 (see all 54):
    hsa-miR-3685 hsa-miR-323-3p hsa-miR-4317 hsa-miR-300 hsa-miR-875-5p hsa-let-7a-2* hsa-miR-301a hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidST18 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ST18
    Predesigned siRNA for gene silencing in human, mouse, rat ST18

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for ST18 (see all 6)
    OriGene ORF clones in mouse, rat for ST18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ST18 (NM_014682)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST18

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ST18 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ST18_HUMAN, O60284: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ST18 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ST18
    Interactions:

        Search GeneGlobe Interaction Network for ST18

    1 Interacting protein for ST18 (O602843) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMC5P621953I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----

    ST18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ST18



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ST18 gene: 
    NM_014682.2  

    Unigene Cluster for ST18:

    Suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)
    Hs.655499  [show with all ESTs]
    Unigene Representative Sequence: NM_014682
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000276480(uc011ldq.1 uc011ldr.1 uc003xqz.2 uc011lds.1 uc003xra.2 uc003xrb.2)
    ENST00000521824 ENST00000522251 ENST00000521582 ENST00000518053 ENST00000522861
    ENST00000518501 ENST00000517580 ENST00000520257 ENST00000521549(uc010lyb.2)
    ENST00000518037 ENST00000517456 ENST00000519118 ENST00000518545 ENST00000521119
    ENST00000518453 ENST00000520279 ENST00000519201
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ST18 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ST18 (see all 54):
    hsa-miR-3685 hsa-miR-323-3p hsa-miR-4317 hsa-miR-300 hsa-miR-875-5p hsa-let-7a-2* hsa-miR-301a hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidST18 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ST18
    Predesigned siRNA for gene silencing in human, mouse, rat ST18
    Clone
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    OriGene clones in human, mouse for ST18 (see all 6)
    OriGene ORF clones in mouse, rat for ST18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ST18 (NM_014682)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST18
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ST18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ST18
      QuantiTect SYBR Green Assays in human, mouse, rat ST18
      QuantiFast Probe-based Assays in human, mouse, rat ST18

    Additional mRNA sequence: 

    AB011107.1 AK311188.1 BC025662.1 BC026316.1 BC031075.1 BC117147.1 BC117149.1 BC143871.1 
    BC143872.1 BC143873.1 BC143875.1 

    10 DOTS entries:

    DT.412961  DT.92036482  DT.40253060  DT.97834849  DT.91747483  DT.95179296  DT.91892517  DT.120635610 
    DT.120635615  DT.97764366 

    Selected AceView cDNA sequences (see all 76):

    AB011107 AI298474 AI298782 BE670703 BX282064 AI350226 BQ953938 BG218123 
    AI741795 AA102556 BX953856 BG216577 NM_014682 BP362876 BX642514 AI458365 
    BI600398 CA943336 CF994459 CB989836 BV206022 BF110433 BE465392 BE550737 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ST18 (see all 19)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b · 13c ^
    SP1:                                      -           -     -     -     -     -     -     -     -           -     -                       -                     
    SP2:                                      -           -     -     -     -     -     -     -     -           -     -                       -                     
    SP3:                                                                                                        -     -                       -                     
    SP4:                                                                                                        -     -                       -           -     -   
    SP5:                                                                                                        -     -                       -     -     -     -   

    ExUns: 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c ^ 30 ^ 31 ^
    SP1:                          -                                                                       -                 -           -                           
    SP2:  -                       -                                                                                                                                 
    SP3:  -                                                                                                                                                         
    SP4:  -                                                                                                                                                         
    SP5:  -                                                                                                                                                         

    ExUns: 32 ^ 33 ^ 34
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for ST18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ST18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACTTTGGT
    ST18 Expression
    About this image


    ST18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 4 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
     
     Bone (Muscoskeletal System)
             Zeugopod Periosteum
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Head Mesenchyme (Muscoskeletal System)
             Frontonasal Process
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
    ST18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ST18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655499

    UniProtKB/Swiss-Prot: ST18_HUMAN, O60284
    Tissue specificity: Detected at low levels in heart, liver, kidney, skeletal muscle, pancreas, testis, ovary and
    prostate. Detected at even lower levels in mammary epithelial cells and breast cancer cells

        Custom PCR Arrays for ST18
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ST18
    QuantiTect SYBR Green Assays in human, mouse, rat ST18
    QuantiFast Probe-based Assays in human, mouse, rat ST18
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ST18 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St181 , 5 suppression of tumorigenicity 181, 5 85.36(n)1
    85.07(a)1
      1 (1.89 cM)5
    2406901  NM_001244692.11  NP_001231621.11 
     64872315 
    chicken
    (Gallus gallus)
    Aves ST181 suppression of tumorigenicity 18 (breast carcinoma) more 80.01(n)
    81(a)
      421115  XM_419199.3  XP_419199.3 
    lizard
    (Anolis carolinensis)
    Reptilia ST186
    suppression of tumorigenicity 18 (breast carcinoma...
    72(a)
    1 ↔ 1
    GL343244.1(1850523-2098155)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia st181 suppression of tumorigenicity 18 (breast carcinoma) more 68.97(n)
    67.26(a)
      100489306  XM_002934112.2  XP_002934158.1 
    zebrafish
    (Danio rerio)
    Actinopterygii st186
    suppression of tumorigenicity 18 (breast carcinoma...
    60(a)
    1 ↔ 1
    24(36615702-36657091) ENSDARG00000091410
    fruit fly
    (Drosophila melanogaster)
    Insecta CG436896
    --
    9(a)
    1 → many
    X(3970107-3986186)
    worm
    (Caenorhabditis elegans)
    Secernentea ztf-116
    Protein ZTF-11, isoform b (ztf-11) mRNA, complete ...
    16(a)
    1 → many
    I(9902943-9910545) WBGene00009939


    ENSEMBL Gene Tree for ST18 (if available)
    TreeFam Gene Tree for ST18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ST18 gene
    MYT1L2  MYT12  
    2 SIMAP similar genes for ST18 using alignment to 7 protein entries:     ST18_HUMAN (see all proteins):
    MYT1    MYT1L

    ST18 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ST18 (see all 5772)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901744601,2
    C--53023051(+) TATACC/TCCGTA 1 -- ds50010--------
    rs1485358461,2
    C--53023053(+) TACTCC/TGTATC 1 -- ds50010--------
    rs625009721,2
    C,F--53023095(+) CTCTAT/CCTTGC 1 -- ds50016Minor allele frequency- C:0.25NA CSA WA EA 364
    rs1931270821,2
    --53023154(+) CCTTAC/TGTCAA 1 -- ds50010--------
    rs1418151911,2
    --53023225(+) CAAAAA/GTCCTG 1 -- ds50010--------
    rs1846874391,2
    --53023276(+) GTCTCC/TGAATG 1 -- ds50010--------
    rs1174667011,2
    C,F--53023279(+) TCCGAA/GTGACT 1 -- ds50011Minor allele frequency- G:0.03NA 120
    rs1506136671,2
    --53023307(+) TCTGGG/TGACCT 1 -- ds50010--------
    rs69949151,2
    C,F,H--53023384(+) AGAAAG/AATCAC 1 -- ds50019Minor allele frequency- A:0.01NS NA 1164
    rs1883080141,2
    --53023389(+) GATCAA/CATCAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ST18 (53023392 - 53273392 bp, first 250kb of ST18)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ST18:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv270428CNV Insertion20981092
    esv2636600CNV Insertion19546169
    dgv7794n71CNV Gain21882294
    nsv831317CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    10 diseases for ST18:    
    About MalaCards
    facial paralysis    primary angle-closure glaucoma    pemphigus vulgaris    pemphigus
    glaucoma    retinitis    alzheimer's disease    pancreatitis
    breast cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for ST18:
    Primary angle-closure glaucoma

    ST18 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ST18
    Human Genome Epidemiology (HuGE) Navigator: ST18 (1 document)

    Export disorders for ST18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ST18 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with ST18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ST18 is a breast cancer tumor suppressor gene at human chromosome 8q11.2. (PubMed id 15489893)1, 2, 3, 9 Jandrig B....Rosenthal A. (Oncogene 2004)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (DNA Res. 1998)
    5. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PubMed id 23535033)1 Sherva R....Green R.C. (amp 2014)
    6. Association study in a South Indian population supports rs1015213 as a risk factor for primary angle closure. (PubMed id 23847314)1 Duvesh R....Sundaresan P. (amp 2013)
    7. Genotype-phenotype analysis of SNPs associated with primary angle closure glaucoma (rs1015213, rs3753841 and rs11024102) and ocular biometry in the EPIC-Norfolk Eye Study. (PubMed id 23505305)1 Day A.C....Foster P.J. (Br J Ophthalmol 2013)
    8. Population-specific association between a polymorphic variant in ST18, encoding a pro-apoptotic molecule, and pemphigus vulgaris. (PubMed id 22437316)1 Sarig O....Sprecher E. (J. Invest. Dermatol. 2012)
    9. The transcription factor ST18 regulates proapoptotic and proinflammatory gene expression in fibroblasts. (PubMed id 18676404)1 Yang J....Graves D.T. (FASEB J. 2008)
    10. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9705 HGNC: 18695 AceView: ST18 Ensembl:ENSG00000147488 euGenes: HUgn9705
    ECgene: ST18 H-InvDB: ST18

    (According to HUGE)
    About This Section

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    HUGE: KIAA0535

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ST18 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ST18 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ST18 gene:
    Search GeneIP for patents involving ST18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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