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ST14 Gene

protein-coding   GIFtS: 70
GCID: GC11P130063

Suppression Of Tumorigenicity 14 (Colon Carcinoma)


(Previous symbol: PRSS14)
  See ST14-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Suppression Of Tumorigenicity 14 (Colon Carcinoma)1 2     matriptase1
PRSS141 2 3     HAI2
Membrane-Type Serine Protease 12 3     TMPRSS142
Serine Protease 142 3     prostamin2
Serine Protease TADG-152 3     Suppression Of Tumorigenicity 14 (Colon Carcinoma, Matriptase, Epithin)2
Tumor-Associated Differentially-Expressed Gene 15 Protein2 3     Suppressor Of Tumorigenicity 14 Protein2
MT-SP12 3     Tumor Associated Differentially Expressed Gene 15 Protein2
SNC192 3     Matriptase3
TADG152 3     Prostamin3
EC 3.4.21.1093 8     ARCI115
MTSP12 5     EC 3.4.218
epithin1     

External Ids:    HGNC: 113441   Entrez Gene: 67682   Ensembl: ENSG000001494187   OMIM: 6067975   UniProtKB: Q9Y5Y63   

Export aliases for ST14 gene to outside databases

Previous GC identifers: GC11P132030 GC11P131542 GC11P129567 GC11P129534 GC11P125980


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ST14 Gene:
The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms
a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine
1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and
urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator
for other proteases and latent growth factors. The expression of this protease has been associated with breast,
colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ST14 Gene:
ST14 (suppression of tumorigenicity 14 (colon carcinoma)) is a protein-coding gene. Diseases associated with ST14 include ichthyosis, congenital, autosomal recessive 11, and ichthyosis, follicular. GO annotations related to this gene include serine-type peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is TMPRSS11D.

UniProtKB/Swiss-Prot: ST14_HUMAN, Q9Y5Y6
Function: Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis.
Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the ST14 gene promoter:
         Max1   MAZR   AML1a   GATA-1   deltaCREB   FOXJ2 (long isoform)   Sox9   FOXJ2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidST14 promoter sequence
   Search Chromatin IP Primers for ST14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24-q25   Ensembl cytogenetic band:  11q24.3   HGNC cytogenetic band: 11q24-q25

ST14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST14 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P130063:  view genomic region     (about GC identifiers)

Start:
130,029,457 bp from pter      End:
130,080,271 bp from pter
Size:
50,815 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ST14_HUMAN, Q9Y5Y6 (See protein sequence)
Recommended Name: Suppressor of tumorigenicity 14 protein  
Size: 855 amino acids; 94770 Da
Subunit: Interacts with CDCP1. May interact with TMEFF1
Selected PDB 3D structures from and Proteopedia for ST14 (see all 15):
1EAW (3D)        1EAX (3D)        2FMV (3D)        2GV6 (3D)        2GV7 (3D)        3BN9 (3D)    
Secondary accessions: Q9BS01 Q9H3S0 Q9HB36 Q9HCA3

Explore the universe of human proteins at neXtProt for ST14: NX_Q9Y5Y6

Explore proteomics data for ST14 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn109, Thr209, Asn302, Asn485, Asn772
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ST14 (Q9Y5Y6) (see all 6)
     GDSGGPL  WPWQVSL  DIALLEL  CQGDSGGP 


    See ST14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_068813.1  
    ENSEMBL proteins: 
     ENSP00000278742  

    ST14 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ST14
    OriGene Custom MassSpec
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    Novus Biologicals ST14 Protein
    Novus Biologicals ST14 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ST14

     
    Search eBioscience for Proteins for ST14 

     
    antibodies-online proteins for ST14 (7 products) 

     
    antibodies-online peptides for ST14

    ST14 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    antibodies-online antibodies for ST14 (83 products) 

    ST14 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ST14
    Cloud-Clone Corp. CLIAs for ST14
    Search eBioscience for ELISAs for ST14 
    antibodies-online kits for ST14 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TMPRSS: Serine peptidases / Transmembrane

    Selected InterPro protein domains (see all 8):
     IPR000859 CUB_dom
     IPR002172 LDrepeatLR_classA_rpt
     IPR023415 LDLR_class-A_CS
     IPR000082 SEA_dom
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y5Y6

    ProtoNet protein and cluster: Q9Y5Y6

    5 Blocks protein domains:
    IPB000082 SEA domain
    IPB000859 CUB domain
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB002172 Low density lipoprotein-receptor


    UniProtKB/Swiss-Prot: ST14_HUMAN, Q9Y5Y6
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 2 CUB domains
    Similarity: Contains 4 LDL-receptor class A domains
    Similarity: Contains 1 peptidase S1 domain
    Similarity: Contains 1 SEA domain


    Find genes that share domains with ST14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST14_HUMAN, Q9Y5Y6
    Function: Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis.
    Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site
    Catalytic activity: Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small
    side-chain amino acids, such as Ala and Gly, at the P2 position

         Genatlas biochemistry entry for ST14:
    suppression of tumorigenicity 14,colon carcinoma,see TSG11F

         Enzyme Numbers (IUBMB): EC 3.4.21.1091 2 EC 3.4.212

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005515protein binding ----
    GO:0008236serine-type peptidase activity IDA19911255
         
    Find genes that share ontologies with ST14           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ST14:
     Decreased homologous recombina  Increased sensitivity to pacli 

         14 MGI mutant phenotypes (inferred from 5 alleles(MGI details for St14):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  mortality/aging  nervous system 

    Find genes that share phenotypes with ST14           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ST14: St14tm1Bug St14tm2Bug

       genOway: Develop your customized and physiologically relevant rodent model for ST14

    miRNA
    Products:
        
    miRTarBase miRNAs that target ST14:
    hsa-mir-615-3p (MIRT039751), hsa-mir-335-5p (MIRT017020), hsa-mir-27b-3p (MIRT003388)

    Block miRNA regulation of human, mouse, rat ST14 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate ST14:
    hsa-miR-33a* hsa-miR-485-5p hsa-miR-4307 hsa-miR-27a hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidST14 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ST14
    Predesigned siRNA for gene silencing in human, mouse, rat ST14

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ST14

    Clone
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    OriGene ORF clones in mouse, rat for ST14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ST14 (NM_021978)
    Sino Biological Human cDNA Clone for ST14
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST14

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ST14
    Browse ESI BIO Cell Lines and PureStem Progenitors for ST14 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ST14_HUMAN, Q9Y5Y6: Membrane; Single-pass type II membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane TAS10373424
    GO:0005887integral component of plasma membrane TAS10831593
    GO:0016020membrane ----

    Find genes that share ontologies with ST14           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ST14 About    
    See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    Death Receptor Signaling0.50
    2MicroRNAs in cancer
    MicroRNAs in cancer


    Find genes that share SuperPaths with ST14           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Sino Biological Pathway for ST14
        Death Receptor Signaling


    1 Kegg Pathway  (Kegg details for ST14):
        MicroRNAs in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ST14
    Interactions:

        GeneGlobe Interaction Network for ST14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for ST14 (Q9Y5Y62, 3 ENSP000002787424) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDCP1Q9H5V83, ENSP000002961294I2D: score=1 STRING: ENSP00000296129
    F2RL1P550853, ENSP000002966774I2D: score=1 STRING: ENSP00000296677
    HGFP142103, ENSP000002223904I2D: score=1 STRING: ENSP00000222390
    SPINT1O432783, ENSP000003420984I2D: score=3 STRING: ENSP00000342098
    PLAUP007493, ENSP000003618504I2D: score=2 STRING: ENSP00000361850
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IDA19911255

    Find genes that share ontologies with ST14           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for ST14
      Browse compounds at ApexBio 

    Browse Tocris compounds for ST14

    2 DrugBank Compounds for ST14    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Benzamidine-- 618-39-3target--17139284 17016423
    UrokinaseU-plasminogen activator (see all 3)9039-53-6target--14747469 12815039

    9 Novoseek inferred chemical compound relationships for ST14 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 84.8 202 12784999 (5), 12549907 (4), 10500122 (3), 11780337 (3) (see all 99)
    ecotin 76.9 1 10500122 (1)
    benzamidine 45.9 3 11696548 (1), 17388811 (1)
    suramin 19.6 11 15590895 (5), 17344310 (1)
    aprotinin 17 1 1562736 (1)
    nitric oxide 0 1 17389401 (1)
    phospholipid 0 1 15075215 (1)
    lipid 0 6 17344310 (1), 16838070 (1)
    calcium 0 3 15305371 (1), 19242518 (1)



    Find genes that share compounds with ST14           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ST14 gene: 
    NM_021978.3  

    Unigene Cluster for ST14:

    Suppression of tumorigenicity 14 (colon carcinoma)
    Hs.504315  [show with all ESTs]
    Unigene Representative Sequence: NM_021978
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000278742(uc001qfw.3) ENST00000530532 ENST00000524718(uc010sca.1)
    ENST00000530376
    miRNA
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    Block miRNA regulation of human, mouse, rat ST14 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate ST14:
    hsa-miR-33a* hsa-miR-485-5p hsa-miR-4307 hsa-miR-27a hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidST14 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ST14
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    GenScript: all cDNA clones in your preferred vector: ST14 (NM_021978)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ST14
      QuantiTect SYBR Green Assays in human, mouse, rat ST14
      QuantiFast Probe-based Assays in human, mouse, rat ST14

    Additional mRNA sequence: 

    AB030036.1 AF057145.1 AF118224.2 AF133086.1 AK302454.1 AK314173.1 BC005826.2 BC018146.1 
    BC030532.1 BC128597.1 

    20 DOTS entries:

    DT.101967801  DT.446293  DT.91759239  DT.87016311  DT.100800553  DT.120726809  DT.75190369  DT.100764700 
    DT.97857725  DT.120726660  DT.95148082  DT.100877693  DT.120726640  DT.91759230  DT.91759237  DT.95148080 
    DT.95148084  DT.120726848  DT.95270653  DT.95322460 

    Selected AceView cDNA sequences (see all 317):

    AI093145 CR620300 AA343593 BG385962 CA489193 AW820710 BX360822 AW007278 
    AW820729 AW263022 BU957199 AI017018 AW089507 BC018146 AA402806 AW820718 
    AI950613 BC005826 AI384037 BQ059215 BX384940 AI354697 BM782467 AI935905 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ST14    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b
    SP1:                                                                                                                              
    SP2:                                                                                                                              


    ECgene alternative splicing isoforms for ST14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ST14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTGCGTGG
    ST14 Expression
    About this image


    ST14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
     
     Epidermis (Integumentary System)    fully expand to see all 2 entries
             Granular Keratinocytes Stratified Epidermis
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
    ST14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ST14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.504315
        Custom PCR Arrays for ST14
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ST14
    OriGene qSTAR qPCR primer pairs in human, mouse for ST14
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    QuantiFast Probe-based Assays in human, mouse, rat ST14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ST14 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St141 , 5 suppression of tumorigenicity 14 (colon carcinoma)1, 5 83.16(n)1
    81.87(a)1
      9 (16.61 cM)5
    191431  NM_011176.41  NP_035306.21 
     310894025 
    chicken
    (Gallus gallus)
    Aves ST141 suppression of tumorigenicity 14 (colon carcinoma) 67.58(n)
    61.92(a)
      419731  XM_417872.4  XP_417872.4 
    lizard
    (Anolis carolinensis)
    Reptilia ST146
    suppression of tumorigenicity 14 (colon carcinoma)...
    58(a)
    1 ↔ 1
    GL343197.1(239961-290311)
    African clawed frog
    (Xenopus laevis)
    Amphibia AB038498.12   -- 72.28(n)    AB038498.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufl72f012 wufl72f01 75.29(n)   334564  57088877 
    rice
    (Oryza sativa)
    Liliopsida U83834.12   -- 92.3(n)    U83834.1 


    ENSEMBL Gene Tree for ST14 (if available)
    TreeFam Gene Tree for ST14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ST14 gene
    TMPRSS11D2  TMPRSS32  TMPRSS11B2  TMPRSS62  TMPRSS11A2  TMPRSS72  TMPRSS52  TMPRSS42  
    TMPRSS132  TMPRSS11E2  KLKB12  TMPRSS22  F112  HPN2  TMPRSS152  TMPRSS11F2  
    Selected SIMAP similar genes for ST14 using alignment to 2 protein entries:     ST14_HUMAN (see all proteins) (see all similar genes):
    serase-1B    DESC1    TMPRSS11E    TMPRSS11D    TMPRSS11F    TMPRSS5
    CTRB1    CTRB2    CTRL    OVCH1    PRSS36    PRSS55
    TMPRSS11A    PRSS27    HPN    TMPRSS11B    DKFZp586F0824    KLKB1

    Find genes that share paralogs with ST14           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ST14 (see all 1277)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0328494
    Ichthyosis, autosomal recessive, with hypotrichosis (ARIH)4--see VAR_0328492 G R mis40--------
    rs349137031,2
    C--126015498(+) TTTTTT/-GAGTC 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1130752191,2
    C--126018431(+) TGTCTC/AAAAAA 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1456260411,2
    C--126018431(+) TGTCT-/CAAAAAA 1 -- int10--------
    rs1508192331,2
    --129896475(+) GCTTTA/GTGTGA 1 -- us2k10--------
    rs780340981,2
    C,F--129896600(+) CGAAAT/CGGTGG 1 -- us2k11Minor allele frequency- C:0.20WA 118
    rs1905652431,2
    --129896669(+) CTGGGG/TAGGAG 1 -- us2k10--------
    rs735851701,2
    C,F--129896683(+) GCATAT/CCAGTC 1 -- us2k14Minor allele frequency- C:0.25WA CSA 123
    rs735851711,2
    C--129896759(+) GCTGAC/ATGACT 1 -- us2k12Minor allele frequency- A:0.16CSA WA 120
    rs1393181901,2
    --129896763(+) ACTGAC/TTCCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ST14 (130029457 - 130080271 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ST14:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1324n71CNV Loss21882294
    nsv517199CNV Loss19592680
    nsv832295CNV Gain17160897
    dgv3e24CNV Gain17666407
    essv12346CNV CNV17122850
    dgv446e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): ST14
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ST14
    DNA2.0 Custom Variant and Variant Library Synthesis for ST14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606797   
    OMIM disorders: 602400  
    UniProtKB/Swiss-Prot: ST14_HUMAN, Q9Y5Y6
  • Ichthyosis, autosomal recessive, with hypotrichosis (ARIH) [MIM:610765]: A skin disorder characterized by
    congenital ichthyosis associated with the presence of less than the normal amount of hair. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • 2 diseases for ST14:    
    About MalaCards
    ichthyosis, congenital, autosomal recessive 11    ichthyosis, follicular

    2 diseases from the University of Copenhagen DISEASES database for ST14:
    Fragile X syndrome     Adrenoleukodystrophy

    Find genes that share disorders with ST14           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ST14 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 49.2 22 16273651 (4), 18649738 (2), 17456594 (1), 19443387 (1) (see all 16)
    cancer 46.1 54 15832373 (4), 20145119 (4), 19243302 (3), 17673379 (2) (see all 29)
    prostate carcinoma 41.6 5 20015050 (1), 10500122 (1), 18649735 (1), 15368474 (1) (see all 5)
    tumors 39.2 73 11948120 (7), 16439987 (5), 17069593 (5), 17163404 (5) (see all 29)
    prostate cancer 37.7 11 18813126 (3), 18649738 (2), 16492908 (1), 15928670 (1) (see all 6)
    breast cancer 34.1 32 12498394 (7), 11290548 (4), 10373425 (3), 16467405 (2) (see all 14)
    carcinoma 33.6 16 16820046 (3), 11290548 (2), 16439987 (2), 19940125 (2) (see all 10)
    pathological processes 32.4 1 17940283 (1)
    prostatic adenocarcinoma 30.8 3 16492908 (1), 18338334 (1), 16467405 (1)
    cervical carcinoma 27.8 9 14584072 (5), 12926053 (1), 16021568 (1)

    Genetic Association Database (GAD): ST14
    Human Genome Epidemiology (HuGE) Navigator: ST14 (7 documents)

    Export disorders for ST14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ST14 gene, integrated from 10 sources (see all 212):
    (articles sorted by number of sources associating them with ST14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity. (PubMed id 10373424)1, 2, 3, 9 Lin C.Y.... Dickson R.B. (J. Biol. Chem. 1999)
    2. The novel serine protease tumor-associated differentially expressed gene-15 (matriptase/MT-SP1) is highly overexpressed in cervical carcinoma. (PubMed id 14584072)1, 4, 9 Santin A.D....Pecorelli S. (Cancer 2003)
    3. Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk. (PubMed id 10373425)1, 2, 9 Lin C.Y.... Dickson R.B. (J. Biol. Chem. 1999)
    4. Inhibition of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinase. (PubMed id 14747469)1, 7, 9 Suzuki M....Terao T. (J. Biol. Chem. 2004)
    5. Protein interaction analysis of ST14 domains and their point and deletion mutants. (PubMed id 16407223)1, 2, 9 Ge W.... Zheng S. (J. Biol. Chem. 2006)
    6. Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue. (PubMed id 10500122)1, 2, 9 Takeuchi T.... Craik C.S. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    7. Assignment1 of human putative tumor suppressor genes ST13 (alias SNC6) and ST14 (alias SNC19) to human chromosome bands 22q13 and 11q24--&gt;q25 by in situ hybridization. (PubMed id 9925927)1, 3, 9 Zhang Y....Zheng S. (Cytogenet. Cell Genet. 1998)
    8. Adhesion signaling by a novel mitotic substrate of src kinases. (PubMed id 16007225)1, 2, 9 Bhatt A.S.... Moasser M.M. (Oncogene 2005)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. ST14 gene variant and decreased matriptase protein expression predict poor breast cancer survival. (PubMed id 20716618)1, 4 Kauppinen J.M....Mannermaa A. (amp 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6768 HGNC: 11344 AceView: ST14 Ensembl:ENSG00000149418 euGenes: HUgn6768
    ECgene: ST14 Kegg: 6768 H-InvDB: ST14

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ST14 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ST14 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ST14 gene:
    Search GeneIP for patents involving ST14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from genOway)
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