Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ST14 Gene

protein-coding   GIFtS: 70
GCID: GC11P130063

Suppression Of Tumorigenicity 14 (Colon Carcinoma)


(Previous symbol: PRSS14)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Suppression Of Tumorigenicity 14 (Colon Carcinoma)1 2     epithin1
PRSS141 2 3     matriptase1
Membrane-Type Serine Protease 12 3     HAI2
Serine Protease 142 3     TMPRSS142
Serine Protease TADG-152 3     prostamin2
Tumor-Associated Differentially-Expressed Gene 15 Protein2 3     Suppression Of Tumorigenicity 14 (Colon Carcinoma, Matriptase, Epithin)2
MT-SP12 3     Suppressor Of Tumorigenicity 14 Protein2
SNC192 3     Tumor Associated Differentially Expressed Gene 15 Protein2
TADG152 3     Matriptase3
EC 3.4.21.1093 8     Prostamin3
MTSP12 5     EC 3.4.218

External Ids:    HGNC: 113441   Entrez Gene: 67682   Ensembl: ENSG000001494187   OMIM: 6067975   UniProtKB: Q9Y5Y63   

Export aliases for ST14 gene to outside databases

Previous GC identifers: GC11P132030 GC11P131542 GC11P129567 GC11P129534 GC11P125980


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ST14 Gene:
The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms
a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine
1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and
urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator
for other proteases and latent growth factors. The expression of this protease has been associated with breast,
colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ST14 Gene: 
ST14 (suppression of tumorigenicity 14 (colon carcinoma)) is a protein-coding gene. Diseases associated with ST14 include ichthyosis with hypotrichosis, and ichthyosis, follicular, and among its related super-pathways are TNF Signaling. GO annotations related to this gene include serine-type peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is TMPRSS11D.

UniProtKB/Swiss-Prot: ST14_HUMAN, Q9Y5Y6
Function: Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis.
Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ST14 gene promoter:
         Max1   MAZR   AML1a   GATA-1   deltaCREB   FOXJ2 (long isoform)   Sox9   FOXJ2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidST14 promoter sequence
   Search SABiosciences Chromatin IP Primers for ST14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24-q25   Ensembl cytogenetic band:  11q24.3   HGNC cytogenetic band: 11q24-q25

ST14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST14 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P130063:  view genomic region     (about GC identifiers)

Start:
130,029,457 bp from pter      End:
130,080,271 bp from pter
Size:
50,815 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ST14_HUMAN, Q9Y5Y6 (See protein sequence)
Recommended Name: Suppressor of tumorigenicity 14 protein  
Size: 855 amino acids; 94770 Da
Subunit: Interacts with CDCP1. May interact with TMEFF1
Subcellular location: Membrane; Single-pass type II membrane protein (Probable)
6/15 PDB 3D structures from and Proteopedia for ST14 (see all 15):
1EAW (3D)        1EAX (3D)        2FMV (3D)        2GV6 (3D)        2GV7 (3D)        3BN9 (3D)    
Secondary accessions: Q9BS01 Q9H3S0 Q9HB36 Q9HCA3

Explore the universe of human proteins at neXtProt for ST14: NX_Q9Y5Y6

Explore proteomics data for ST14 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y5Y6

  • 4/6 DME Specific Peptides for ST14 (Q9Y5Y6) (see all 6)
     GDSGGPL  WPWQVSL  DIALLEL  CQGDSGGP 

    ST14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ST14 Protein Expression
    REFSEQ proteins: NP_068813.1  
    ENSEMBL proteins: 
     ENSP00000278742  

    Human Recombinant Protein Products for ST14: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ST14 (Matriptase/ST14)
    Enzo Life Sciences proteins for ST14
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ST14
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ST14
    GenScript Custom Purified and Recombinant Proteins Services for ST14
    Novus Biologicals ST14 Protein
    Novus Biologicals ST14 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ST14 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS10373424
    GO:0005887integral to plasma membrane TAS10831593
    GO:0016020membrane ----
    GO:0019897extrinsic to plasma membrane IEA--

    ST14 for ontologies           About GeneDecksing



    ST14 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for ST14 (Matriptase/ST14)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ST14
    GenScript Custom Superior Antibodies Services for ST14
    Novus Biologicals ST14 Antibodies
    Abcam antibodies for ST14
    Cloud-Clone Corp. Antibodies for ST14 
    ThermoFisher Antibody for ST14
    LSBio Antibodies in human, mouse, rat for ST14 

    Assay Products for ST14: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ST14
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ST14
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ST14 
    Cloud-Clone Corp. CLIAs for ST14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TMPRSS: Serine peptidases / Transmembrane

    5/8 InterPro protein domains (see all 8):
     IPR000859 CUB_dom
     IPR002172 LDrepeatLR_classA_rpt
     IPR023415 LDLR_class-A_CS
     IPR000082 SEA_dom
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y5Y6

    ProtoNet protein and cluster: Q9Y5Y6

    5 Blocks protein domains:
    IPB000082 SEA domain
    IPB000859 CUB domain
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB002172 Low density lipoprotein-receptor


    UniProtKB/Swiss-Prot: ST14_HUMAN, Q9Y5Y6
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 2 CUB domains
    Similarity: Contains 4 LDL-receptor class A domains
    Similarity: Contains 1 peptidase S1 domain


    ST14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ST14_HUMAN, Q9Y5Y6
    Function: Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis.
    Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site
    Catalytic activity: Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small
    side-chain amino acids, such as Ala and Gly, at the P2 position

         Genatlas biochemistry entry for ST14:
    suppression of tumorigenicity 14,colon carcinoma,see TSG11F

         Enzyme Numbers (IUBMB): EC 3.4.21.1091 2 EC 3.4.212

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005515protein binding ----
    GO:0008236serine-type peptidase activity IDA19911255
         
    ST14 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ST14:
     Decreased homologous recombina  Increased sensitivity to pacli 

         14 MGI mutant phenotypes (inferred from 5 alleles(MGI details for St14):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  mortality/aging  nervous system 

    ST14 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ST14: St14tm1Bug St14tm2Bug

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ST14 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ST14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ST14 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ST14 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ST14:
    hsa-mir-27b (MIRT003388)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST14
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate ST14:
    hsa-miR-33a* hsa-miR-485-5p hsa-miR-4307 hsa-miR-27a hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidST14 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ST14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST14

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ST14
    Sirion Biotech Customized adenovirus for overexpression of ST14

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ST14 (see all 8)
    OriGene ORF clones in mouse, rat for ST14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ST14 (NM_021978)
    Sino Biological Human cDNA Clone for ST14
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST14
    Sirion Biotech Customized lentivirus for stable overexpression of ST14 
                         Customized lentivirus expression plasmids for stable overexpression of ST14 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ST14
    Search LifeMap BioReagents cell lines for ST14
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST14


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ST14 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    Death Receptor Signaling0.50
    2MicroRNAs in cancer
    MicroRNAs in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Sino Biological Pathway for ST14 
        Death Receptor Signaling


    1         Kegg Pathway  (Kegg details for ST14):
        MicroRNAs in cancer


    ST14 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ST14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for ST14 (Q9Y5Y62, 3 ENSP000002787424) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDCP1Q9H5V83, ENSP000002961294I2D: score=1 STRING: ENSP00000296129
    F2RL1P550853, ENSP000002966774I2D: score=1 STRING: ENSP00000296677
    HGFP142103, ENSP000002223904I2D: score=1 STRING: ENSP00000222390
    SPINT1O432783, ENSP000003420984I2D: score=3 STRING: ENSP00000342098
    PLAUP007493, ENSP000003618504I2D: score=2 STRING: ENSP00000361850
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IDA19911255

    ST14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ST14 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for ST14

    Browse Tocris compounds for ST14

    2 DrugBank Compounds for ST14    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Benzamidine-- 618-39-3target--17139284 17016423
    UrokinaseU-plasminogen activator (see all 3)9039-53-6target--14747469 12815039

    9 Novoseek inferred chemical compound relationships for ST14 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 84.8 202 12784999 (5), 12549907 (4), 10500122 (3), 11780337 (3) (see all 99)
    ecotin 76.9 1 10500122 (1)
    benzamidine 45.9 3 11696548 (1), 17388811 (1)
    suramin 19.6 11 15590895 (5), 17344310 (1)
    aprotinin 17 1 1562736 (1)
    nitric oxide 0 1 17389401 (1)
    phospholipid 0 1 15075215 (1)
    lipid 0 6 17344310 (1), 16838070 (1)
    calcium 0 3 15305371 (1), 19242518 (1)

    Search CenterWatch for drugs/clinical trials and news about ST14

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ST14 gene: 
    NM_021978.3  

    Unigene Cluster for ST14:

    Suppression of tumorigenicity 14 (colon carcinoma)
    Hs.504315  [show with all ESTs]
    Unigene Representative Sequence: NM_021978
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000278742(uc001qfw.3) ENST00000530532 ENST00000524718(uc010sca.1)
    ENST00000530376
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST14
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate ST14:
    hsa-miR-33a* hsa-miR-485-5p hsa-miR-4307 hsa-miR-27a hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidST14 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ST14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST14
    Clone
    Products:
         
    OriGene clones in human, mouse for ST14 (see all 8)
    OriGene ORF clones in mouse, rat for ST14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ST14 (NM_021978)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST14
    Sirion Biotech Customized lentivirus for stable overexpression of ST14 
                         Customized lentivirus expression plasmids for stable overexpression of ST14 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ST14
    OriGene qSTAR qPCR primer pairs in human, mouse for ST14
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ST14
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ST14
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST14

    Additional mRNA sequence: 

    AB030036.1 AF057145.1 AF118224.2 AF133086.1 AK302454.1 AK314173.1 BC005826.2 BC018146.1 
    BC030532.1 BC128597.1 

    20 DOTS entries:

    DT.101967801  DT.446293  DT.91759239  DT.87016311  DT.100800553  DT.120726809  DT.75190369  DT.100764700 
    DT.97857725  DT.120726660  DT.95148082  DT.100877693  DT.120726640  DT.91759230  DT.91759237  DT.95148080 
    DT.95148084  DT.120726848  DT.95270653  DT.95322460 

    24/317 AceView cDNA sequences (see all 317):

    AW820732 AA343593 AW820719 BG385962 BG679913 CA489193 BC030532 AW074173 
    AI354697 BQ066710 BG468516 AW820729 BM782467 BU957199 AW820725 AW263022 
    AI950613 BC005826 AI384037 AA402806 BX384940 AW089507 CR620300 AB030036 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ST14    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b
    SP1:                                                                                                                              
    SP2:                                                                                                                              


    ECgene alternative splicing isoforms for ST14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ST14 expression in normal human tissues (normalized intensities)      ST14 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTGCGTGG
    ST14 Expression
    About this image


    ST14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             visceral organ/oral region/upper jaw   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ/urethra of male   
     
     Epidermis (Integumentary System)    fully expand to see all 2 entries
             Granular Keratinocytes Stratified Epidermis

    See ST14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ST14

    SOURCE GeneReport for Unigene cluster: Hs.504315
        SABiosciences Custom PCR Arrays for ST14
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ST14
    OriGene qSTAR qPCR primer pairs in human, mouse for ST14
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ST14
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ST14
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ST14 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St141 , 5 suppression of tumorigenicity 14 (colon carcinoma)1, 5 83.16(n)1
    81.87(a)1
      9 (16.61 cM)5
    191431  NM_011176.41  NP_035306.21 
     310894025 
    chicken
    (Gallus gallus)
    Aves ST141 suppression of tumorigenicity 14 (colon carcinoma) 68.41(n)
    62.99(a)
      419731  XM_417872.3  XP_417872.3 
    lizard
    (Anolis carolinensis)
    Reptilia ST146
    suppression of tumorigenicity 14 (colon carcinoma)...
    57(a)
    1 ↔ 1
    GL343197.1(239961-290311)
    African clawed frog
    (Xenopus laevis)
    Amphibia AB038498.12   -- 72.28(n)    AB038498.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufl72f012 wufl72f01 75.29(n)   334564  57088877 
    worm
    (Caenorhabditis elegans)
    Secernentea C07G1.13 peptidase 37(a)   IV(8212766-8213851)   --
    rice
    (Oryza sativa)
    Liliopsida U83834.12   -- 92.3(n)    U83834.1 


    ENSEMBL Gene Tree for ST14 (if available)
    TreeFam Gene Tree for ST14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ST14 gene
    TMPRSS11D2  TMPRSS32  TMPRSS11B2  TMPRSS62  TMPRSS11A2  TMPRSS72  TMPRSS52  TMPRSS42  
    TMPRSS132  TMPRSS11E2  KLKB12  TMPRSS22  F112  HPN2  TMPRSS152  TMPRSS11F2  
    18/53 SIMAP similar genes for ST14 using alignment to 2 protein entries:     ST14_HUMAN (see all proteins) (see all similar genes):
    serase-1B    DESC1    TMPRSS11E    TMPRSS11D    TMPRSS11F    TMPRSS5
    CTRB1    CTRB2    CTRL    OVCH1    PRSS36    PRSS55
    TMPRSS11A    PRSS27    HPN    TMPRSS11B    DKFZp586F0824    KLKB1

    ST14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1277 SNPs in ST14 are shown (see all 1277)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0328494
    Ichthyosis, autosomal recessive, with hypotrichosis (ARIH)4--see VAR_0328492 G R mis40--------
    rs349137031,2
    C--126015498(+) TTTTTT/-GAGTC 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1130752191,2
    C--126018431(+) TGTCTC/AAAAAA 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1456260411,2
    C--126018431(+) TGTCT-/CAAAAAA 1 -- int10--------
    rs1508192331,2
    --129896475(+) GCTTTA/GTGTGA 1 -- us2k10--------
    rs780340981,2
    C,F--129896600(+) CGAAAT/CGGTGG 1 -- us2k11Minor allele frequency- C:0.20WA 118
    rs1905652431,2
    --129896669(+) CTGGGG/TAGGAG 1 -- us2k10--------
    rs735851701,2
    C,F--129896683(+) GCATAT/CCAGTC 1 -- us2k14Minor allele frequency- C:0.25WA CSA 123
    rs735851711,2
    C--129896759(+) GCTGAC/ATGACT 1 -- us2k12Minor allele frequency- A:0.16CSA WA 120
    rs1393181901,2
    --129896763(+) ACTGAC/TTCCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ST14 (130029457 - 130080271 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ST14:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1324n71CNV Loss21882294
    nsv517199CNV Loss19592680
    nsv832295CNV Gain17160897
    dgv3e24CNV Gain17666407
    essv12346CNV CNV17122850
    dgv446e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): ST14
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ST14
    DNA2.0 Custom Variant and Variant Library Synthesis for ST14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606797   
    OMIM disorders: 610765  
    UniProtKB/Swiss-Prot: ST14_HUMAN, Q9Y5Y6
  • Ichthyosis, autosomal recessive, with hypotrichosis (ARIH) [MIM:610765]: A skin disorder characterized by
    congenital ichthyosis associated with the presence of less than the normal amount of hair. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • 20/43 diseases for ST14 (see all 43):    About MalaCards
    ichthyosis with hypotrichosis    ichthyosis, follicular    hypotrichosis    microcytic anemia
    emery-dreifuss muscular dystrophy    color blindness    prostate adenocarcinoma    bulimia nervosa
    ichthyosis    fragile x syndrome    hemophilia    adrenoleukodystrophy
    fibrosarcoma    prostatitis    skin cancer    prostate cancer, progression of
    pancreatic ductal adenocarcinoma    malignant mesothelioma    blindness    ovarian cancer

    2 diseases from the University of Copenhagen DISEASES database for ST14:
    Fragile X syndrome     Adrenoleukodystrophy

    ST14 for disorders           About GeneDecksing

    10/28 Novoseek inferred disease relationships for ST14 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 49.2 22 16273651 (4), 18649738 (2), 17456594 (1), 19443387 (1) (see all 16)
    cancer 46.1 54 15832373 (4), 20145119 (4), 19243302 (3), 17673379 (2) (see all 29)
    prostate carcinoma 41.6 5 20015050 (1), 10500122 (1), 18649735 (1), 15368474 (1) (see all 5)
    tumors 39.2 73 11948120 (7), 16439987 (5), 17069593 (5), 17163404 (5) (see all 29)
    prostate cancer 37.7 11 18813126 (3), 18649738 (2), 16492908 (1), 15928670 (1) (see all 6)
    breast cancer 34.1 32 12498394 (7), 11290548 (4), 10373425 (3), 16467405 (2) (see all 14)
    carcinoma 33.6 16 16820046 (3), 11290548 (2), 16439987 (2), 19940125 (2) (see all 10)
    pathological processes 32.4 1 17940283 (1)
    prostatic adenocarcinoma 30.8 3 16492908 (1), 18338334 (1), 16467405 (1)
    cervical carcinoma 27.8 9 14584072 (5), 12926053 (1), 16021568 (1)

    Genetic Association Database (GAD): ST14
    Human Genome Epidemiology (HuGE) Navigator: ST14 (7 documents)

    Export disorders for ST14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ST14 gene, integrated from 9 sources (see all 208):
    (articles sorted by number of sources associating them with ST14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity. (PubMed id 10373424)1, 2, 3, 9 Lin C.Y.... Dickson R.B. (1999)
    2. The novel serine protease tumor-associated differentially expressed gene-15 (matriptase/MT-SP1) is highly overexpressed in cervical carcinoma. (PubMed id 14584072)1, 4, 9 Santin A.D....Pecorelli S. (2003)
    3. Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk. (PubMed id 10373425)1, 2, 9 Lin C.Y.... Dickson R.B. (1999)
    4. Inhibition of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinase. (PubMed id 14747469)1, 7, 9 Suzuki M....Terao T. (2004)
    5. Protein interaction analysis of ST14 domains and their point and deletion mutants. (PubMed id 16407223)1, 2, 9 Ge W.... Zheng S. (2006)
    6. Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue. (PubMed id 10500122)1, 2, 9 Takeuchi T.... Craik C.S. (1999)
    7. Assignment1 of human putative tumor suppressor genes ST13 (alias SNC6) and ST14 (alias SNC19) to human chromosome bands 22q13 and 11q24-->q25 by in situ hybridization. (PubMed id 9925927)1, 3, 9 Zhang Y....Zheng S. (1998)
    8. Adhesion signaling by a novel mitotic substrate of src kinases. (PubMed id 16007225)1, 2, 9 Bhatt A.S.... Moasser M.M. (2005)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    10. ST14 gene variant and decreased matriptase protein ex pression predict poor breast cancer survival. (PubMed id 20716618)1, 4 Kauppinen J.M....Mannermaa A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6768 HGNC: 11344 AceView: ST14 Ensembl:ENSG00000149418 euGenes: HUgn6768
    ECgene: ST14 Kegg: 6768 H-InvDB: ST14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ST14 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ST14 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ST14 gene:
    Search GeneIP for patents involving ST14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for ST14 (Matriptase/ST14)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for ST14 (Matriptase/ST14)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ST14  
     OriGene qPCR primer pairs and template standards for ST14   OriGene Protein Over-expression Lysate for ST14  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ST14  
     OriGene qSTAR qPCR primer pairs in human, mouse for ST14   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ST14   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ST14   OriGene Custom Protein Services for ST14  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ST14
     QIAGEN SeqTarget long-range PCR primers for resequencing ST14
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST14
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST14
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST14
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ST14
     GenScript Custom Purified and Recombinant Proteins Services for ST14 GenScript cDNA clones with any tag delivered in your preferred vector for ST14
     GenScript Custom Assay Services for ST14 GenScript Custom Superior Antibodies Services for ST14
     GenScript Custom overexpressing Cell Line Services for ST14 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ST14 promoter
     Search Chromatin IP Primers for ST14
     RT2 qPCR Primer Assay in human, mouse, rat ST14
     GNC Network for ST14
     SABiosciences Custom PCR Arrays for ST14
     Search Tocris compounds for ST14
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for ST14
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs/Proteins for ST14
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ST14 antibodies
     ST14 proteins
     ST14 lysates
     Antibodies for ST14
     See all of Abcam's Antibodies, Kits and Proteins for ST14
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ST14
     Antibodies for ST14
     ELISAs for ST14
     CLIAs for ST14
     Search LifeMap BioReagents cell lines for ST14
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST14
     SwitchGear 3'UTR luciferase reporter plasmids for ST14
     SwitchGear Promoter luciferase reporter plasmids for ST14
     ThermoFisher Antibody for ST14
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST14
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ST14
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ST14
    Customized:
     lentivirus for stable overexpression of ST14
     lentivirus expression plasmids for stable overexpression of ST14
     adenovirus for overexpression of ST14
     LSBio Antibodies in human, mouse, rat for ST14
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ST14 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4