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Aliases for ST14 Gene

Aliases for ST14 Gene

  • Suppression Of Tumorigenicity 14 (Colon Carcinoma) 2 3
  • Tumor-Associated Differentially-Expressed Gene 15 Protein 3 4
  • Membrane-Type Serine Protease 1 3 4
  • Serine Protease TADG-15 3 4
  • Serine Protease 14 3 4
  • EC 3.4.21.109 4 63
  • Matriptase 2 4
  • Prostamin 3 4
  • PRSS14 3 4
  • ARCI11 3 6
  • MT-SP1 3 4
  • TADG15 3 4
  • MTSP1 3 6
  • SNC19 3 4
  • Suppression Of Tumorigenicity 14 (Colon Carcinoma, Matriptase, Epithin) 3
  • Tumor Associated Differentially Expressed Gene 15 Protein 3
  • Suppressor Of Tumorigenicity 14 Protein 3
  • EC 3.4.21 63
  • TMPRSS14 3
  • Epithin 2
  • HAI 3

External Ids for ST14 Gene

Previous HGNC Symbols for ST14 Gene

  • PRSS14

Previous GeneCards Identifiers for ST14 Gene

  • GC11P132030
  • GC11P131542
  • GC11P130063
  • GC11P129567
  • GC11P129534
  • GC11P125980

Summaries for ST14 Gene

Entrez Gene Summary for ST14 Gene

  • The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST14 Gene

ST14 (Suppression Of Tumorigenicity 14 (Colon Carcinoma)) is a Protein Coding gene. Diseases associated with ST14 include ichthyosis, congenital, autosomal recessive 11 and ichthyosis-hypotrichosis syndrome. Among its related pathways are MicroRNAs in cancer and TNF Signaling. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is HPN.

UniProtKB/Swiss-Prot for ST14 Gene

  • Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST14 Gene

Genomics for ST14 Gene

Regulatory Elements for ST14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ST14 Gene

Start:
130,159,562 bp from pter
End:
130,210,376 bp from pter
Size:
50,815 bases
Orientation:
Plus strand

Genomic View for ST14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ST14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST14 Gene

Proteins for ST14 Gene

  • Protein details for ST14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Y6-ST14_HUMAN
    Recommended name:
    Suppressor of tumorigenicity 14 protein
    Protein Accession:
    Q9Y5Y6
    Secondary Accessions:
    • Q9BS01
    • Q9H3S0
    • Q9HB36
    • Q9HCA3

    Protein attributes for ST14 Gene

    Size:
    855 amino acids
    Molecular mass:
    94770 Da
    Quaternary structure:
    • Interacts with CDCP1. May interact with TMEFF1.

    Three dimensional structures from OCA and Proteopedia for ST14 Gene

neXtProt entry for ST14 Gene

Proteomics data for ST14 Gene at MOPED

Selected DME Specific Peptides for ST14 Gene

Post-translational modifications for ST14 Gene

  • Glycosylation at Asn109, Thr209, Asn302, Asn485, and Asn772
  • Modification sites at PhosphoSitePlus

Other Protein References for ST14 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ST14 (Matriptase/ST14)

Domains for ST14 Gene

Gene Families for ST14 Gene

HGNC:
  • TMPRSS :Serine peptidases / Transmembrane

Suggested Antigen Peptide Sequences for ST14 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5Y6

UniProtKB/Swiss-Prot:

ST14_HUMAN :
  • Q9Y5Y6
Domain:
  • Contains 2 CUB domains.
  • Contains 4 LDL-receptor class A domains.
  • Contains 1 peptidase S1 domain.
  • Contains 1 SEA domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with ST14: view

Function for ST14 Gene

Molecular function for ST14 Gene

GENATLAS Biochemistry: suppression of tumorigenicity 14,colon carcinoma,see TSG11F
UniProtKB/Swiss-Prot CatalyticActivity: Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position.
UniProtKB/Swiss-Prot Function: Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing.

Enzyme Numbers (IUBMB) for ST14 Gene

Gene Ontology (GO) - Molecular Function for ST14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005515 protein binding --
GO:0008236 serine-type peptidase activity IDA 19911255
genes like me logo Genes that share ontologies with ST14: view
genes like me logo Genes that share phenotypes with ST14: view

Animal Models for ST14 Gene

MGI Knock Outs for ST14:

Animal Model Products

miRNA for ST14 Gene

miRTarBase miRNAs that target ST14

No data available for Transcription Factor Targeting and HOMER Transcription for ST14 Gene

Localization for ST14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST14 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST14 Gene COMPARTMENTS Subcellular localization image for ST14 gene
Compartment Confidence
plasma membrane 4
extracellular 2

Gene Ontology (GO) - Cellular Components for ST14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS 10373424
GO:0005887 integral component of plasma membrane TAS 10831593
GO:0016020 membrane --
genes like me logo Genes that share ontologies with ST14: view

Pathways for ST14 Gene

genes like me logo Genes that share pathways with ST14: view

Pathways by source for ST14 Gene

1 Sino Biological pathway for ST14 Gene
1 KEGG pathway for ST14 Gene

Gene Ontology (GO) - Biological Process for ST14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 19911255
GO:0030216 keratinocyte differentiation IMP 18843291
genes like me logo Genes that share ontologies with ST14: view

Compounds for ST14 Gene

(2) Drugbank Compounds for ST14 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Benzamidine
618-39-3 target
Urokinase
  • U-plasminogen activator
9039-53-6 target

(9) Novoseek inferred chemical compound relationships for ST14 Gene

Compound -log(P) Hits PubMed IDs
serine 84.8 135
ecotin 76.9 1
benzamidine 45.9 2
suramin 19.6 6
aprotinin 17 1
genes like me logo Genes that share compounds with ST14: view

Transcripts for ST14 Gene

mRNA/cDNA for ST14 Gene

Unigene Clusters for ST14 Gene

Suppression of tumorigenicity 14 (colon carcinoma):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ST14

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST14 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b
SP1:
SP2:

Relevant External Links for ST14 Gene

GeneLoc Exon Structure for
ST14
ECgene alternative splicing isoforms for
ST14

Expression for ST14 Gene

mRNA expression in normal human tissues for ST14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST14 Gene

This gene is overexpressed in Colon - Transverse (9.9), Esophagus - Mucosa (5.9), and Small Intestine - Terminal Ileum (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ST14 Gene

SOURCE GeneReport for Unigene cluster for ST14 Gene Hs.504315

genes like me logo Genes that share expressions with ST14: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ST14 Gene

Orthologs for ST14 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST14 35
  • 98.95 (n)
  • 99.3 (a)
ST14 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ST14 35
  • 81.75 (n)
  • 77.08 (a)
ST14 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ST14 35
  • 85.33 (n)
  • 82.32 (a)
ST14 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St14 35
  • 83.16 (n)
  • 81.87 (a)
St14 16
St14 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ST14 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ST14 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia St14 35
  • 82.85 (n)
  • 81.17 (a)
chicken
(Gallus gallus)
Aves ST14 35
  • 67.58 (n)
  • 61.92 (a)
ST14 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST14 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st14 35
  • 58.06 (n)
  • 55.41 (a)
zebrafish
(Danio rerio)
Actinopterygii ST14 (2 of 3) 36
  • 45 (a)
OneToMany
st14a 35
  • 54.95 (n)
  • 49.32 (a)
st14a 36
  • 47 (a)
OneToMany
st14b 36
  • 44 (a)
OneToMany
wufl72f01 35
fruit fly
(Drosophila melanogaster)
Insecta CG5197 37
  • 35 (a)
Try29F 37
  • 38 (a)
CG4386 37
  • 37 (a)
CG1299 37
  • 34 (a)
CG18735 37
  • 38 (a)
Sb 37
  • 38 (a)
EG:80H7.3 37
  • 34 (a)
CG8213 37
  • 34 (a)
CG7432 37
  • 35 (a)
CG4914 37
  • 39 (a)
CG9294 37
  • 38 (a)
CG18065 37
  • 37 (a)
CG11824 37
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea C07G1.1 37
  • 37 (a)
Species with no ortholog for ST14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ST14 Gene

ENSEMBL:
Gene Tree for ST14 (if available)
TreeFam:
Gene Tree for ST14 (if available)

Paralogs for ST14 Gene

genes like me logo Genes that share paralogs with ST14: view

Variants for ST14 Gene

Sequence variations from dbSNP and Humsavar for ST14 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs5852 -- 130,210,170(+) TTCGG(A/G)GCCTC utr-variant-3-prime
rs11419 -- 130,210,134(-) ACAGG(C/G/T)GAGGC utr-variant-3-prime
rs476106 -- 130,196,440(+) ATCAA(C/T)GGGGA reference, synonymous-codon
rs478745 -- 130,190,322(+) TTTCC(C/T)GAGGC intron-variant
rs489573 -- 130,183,476(+) gctga(C/T)gcagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST14 Gene

Variant ID Type Subtype PubMed ID
nsv832295 CNV Gain 17160897
essv12346 CNV CNV 17122850
dgv446e1 CNV Complex 17122850
nsv517199 CNV Loss 19592680
dgv1324n71 CNV Loss 21882294
dgv3e24 CNV Gain 17666407

Relevant External Links for ST14 Gene

HapMap Linkage Disequilibrium report
ST14
Human Gene Mutation Database (HGMD)
ST14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST14 Gene

Disorders for ST14 Gene

(1) OMIM Diseases for ST14 Gene (606797)

UniProtKB/Swiss-Prot

ST14_HUMAN
  • Ichthyosis, congenital, autosomal recessive 11 (ARCI11) [MIM:602400]: A form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. {ECO:0000269 PubMed:17273967, ECO:0000269 PubMed:18843291}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for ST14 Gene

(28) Novoseek inferred disease relationships for ST14 Gene

Disease -log(P) Hits PubMed IDs
metastasis 49.2 20
cancer 46.1 41
prostate carcinoma 41.6 5
tumors 39.2 60
prostate cancer 37.7 9

Relevant External Links for ST14

Genetic Association Database (GAD)
ST14
Human Genome Epidemiology (HuGE) Navigator
ST14
genes like me logo Genes that share disorders with ST14: view

Publications for ST14 Gene

  1. Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity. (PMID: 10373424) Lin C.Y. … Dickson R.B. (J. Biol. Chem. 1999) 2 3 4 23
  2. Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk. (PMID: 10373425) Lin C.Y. … Dickson R.B. (J. Biol. Chem. 1999) 3 4 23
  3. Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue. (PMID: 10500122) Takeuchi T. … Craik C.S. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 23
  4. The novel serine protease tumor-associated differentially expressed gene-15 (matriptase/MT-SP1) is highly overexpressed in cervical carcinoma. (PMID: 14584072) Santin A.D. … Pecorelli S. (Cancer 2003) 3 23 48
  5. Adhesion signaling by a novel mitotic substrate of src kinases. (PMID: 16007225) Bhatt A.S. … Moasser M.M. (Oncogene 2005) 3 4 23

Products for ST14 Gene

Sources for ST14 Gene

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