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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ST14 Gene

protein-coding GIFtS: 65
GCID: GC11P130063

suppression of tumorigenicity 14 (colon carcinoma)

(Previous symbol: PRSS14)

Explore 47 diseases affiliated with
ST14 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Suppression Of Tumorigenicity 14 (Colon Carcinoma)¹ ²		TADG15² ³
MT-SP1¹ ² ³		EC 3.4.21.109³ ⁸
PRSS14¹ ² ³		MTSP1² ⁵
SNC19¹ ² ³		Prostamin³
HAI¹ ²		Suppression Of Tumorigenicity 14 (Colon Carcinoma, Matriptase, Epithin)²
TMPRSS14¹ ²		Suppressor Of Tumorigenicity 14 Protein²
Membrane-Type Serine Protease 1² ³		Tumor Associated Differentially Expressed Gene 15 Protein²
Serine Protease 14² ³		Matriptase³
Serine Protease TADG-15² ³		Prostamin³
Tumor-Associated Differentially-Expressed Gene 15 Protein² ³		EC 3.4.21⁸

External Ids:	HGNC: 11344¹	Entrez Gene: 6768²	Ensembl: ENSG00000149418⁷	OMIM: 606797⁵	UniProtKB: Q9Y5Y6³

Export aliases for ST14 gene to outside databases

Previous GC identifers: GC11P132030 GC11P131542 GC11P129567 GC11P129534 GC11P125980

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ST14:

The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a

complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine

1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and

urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for

other proteases and latent growth factors. The expression of this protease has been associated with breast, colon,

prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: ST14_HUMAN, Q9Y5Y6

Function: Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits

trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ST14 gene promoter:
Max1 MAZR AML1a GATA-1 deltaCREB FOXJ2 (long isoform) Sox9 FOXJ2 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ST14 promoter sequence

Search SABiosciences Chromatin IP Primers for ST14

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST14

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24-q25 Ensembl cytogenetic band: 11q24.3 HGNC cytogenetic band: 11q24-q25

ST14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST14 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P130063: view genomic region (about GC identifiers)

Start:	130,029,457 bp from pter	End:	130,080,356 bp from pter
Size:	50,900 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ST14_HUMAN, Q9Y5Y6 (See protein sequence)

Recommended Name: Suppressor of tumorigenicity 14 protein

Size: 855 amino acids; 94770 Da

Subunit: Interacts with CDCP1. May interact with TMEFF1

Subcellular location: Membrane; Single-pass type II membrane protein (Probable)

6/11 PDB 3D structures from and Proteopedia for ST14 (see all 11):

1EAW (3D)

1EAX (3D)

2FMV (3D)

2GV6 (3D)

2GV7 (3D)

3BN9 (3D)

Secondary accessions: Q9BS01 Q9H3S0 Q9HB36 Q9HCA3

Explore the universe of human proteins at neXtProt for ST14: NX_Q9Y5Y6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y5Y6

4/6 DME Specific Peptides for ST14 (Q9Y5Y6) (see all 6)

GDSGGPL

WPWQVSL

DIALLEL

CQGDSGGP

ST14 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_068813.1

ENSEMBL proteins:

ENSP00000278742 ENSP00000432772

Human Recombinant Protein Products for ST14:

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	Novus Biologicals ST14 Protein Novus Biologicals ST14 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ST14

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	--	--
GO:0005886	plasma membrane	TAS	10831593
GO:0005887	integral to plasma membrane	TAS	10831593
GO:0016323	basolateral plasma membrane	--	--

ST14 for ontologies About GeneDecksing

ST14 Antibody Products:

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	Uscn ELISAs and CLIAs for ST14

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ST14 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR000859 CUB_dom

IPR002172 LDrepeatLR_classA_rpt

IPR023415 LDLR_class-A_CS

IPR000082 SEA

IPR009003 Trypsin-like_Pept_dom

Graphical View of Domain Structure for InterPro Entry Q9Y5Y6

ProtoNet protein and cluster: Q9Y5Y6

5 Blocks protein families:

IPB000082 SEA domain

IPB000859 CUB domain

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

IPB002172 Low density lipoprotein-receptor

UniProtKB/Swiss-Prot: ST14_HUMAN, Q9Y5Y6

Similarity: Belongs to the peptidase S1 family

Similarity: Contains 2 CUB domains

Similarity: Contains 4 LDL-receptor class A domains

Similarity: Contains 1 peptidase S1 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ST14_HUMAN, Q9Y5Y6

Function: Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits

trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site

Catalytic activity: Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small

side-chain amino acids, such as Ala and Gly, at the P2 position

Genatlas biochemistry entry for ST14:

suppression of tumorigenicity 14,colon carcinoma,see TSG11F

Enzyme Numbers (IUBMB): EC 3.4.21.109¹ ² EC 3.4.21²

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004252	serine-type endopeptidase activity	IEA	--
GO:0008236	serine-type peptidase activity	IDA	19911255

ST14 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for ST14:

Decreased homologous recombina

Increased sensitivity to pacli

14 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for St14):

behavior/neurological	cellular	craniofacial	digestive/alimentary	embryogenesis
endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism	immune system
integument	limbs/digits/tail	mortality/aging	nervous system

ST14 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for ST14: St14^tm1Bug St14^tm2Bug

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ST14

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST14
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate ST14:
		hsa-miR-33a* hsa-miR-485-5p hsa-miR-4307 hsa-miR-27a hsa-miR-27b
		SwitchGear 3'UTR luciferase reporter plasmid: ST14 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST14

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ST14

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/11 Interacting proteins for ST14 (Q9Y5Y6^{2, 3} ENSP00000278742⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDCP1	Q9H5V8³, ENSP00000296129⁴	I2D: score=1 STRING: ENSP00000296129
F2RL1	P55085³, ENSP00000296677⁴	I2D: score=1 STRING: ENSP00000296677
HGF	P14210³, ENSP00000222390⁴	I2D: score=1 STRING: ENSP00000222390
SPINT1	O43278³, ENSP00000342098⁴	I2D: score=3 STRING: ENSP00000342098
PLAU	P00749³, ENSP00000361850⁴	I2D: score=2 STRING: ENSP00000361850

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IDA	19911255

ST14 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ST14 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for ST14

Browse Tocris compounds for ST14

2 DrugBank Compounds for ST14 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Benzamidine	--	618-39-3	target	--	17139284 17016423
Urokinase	U-plasminogen activator (see all 3)	9039-53-6	target	--	14747469 12815039

9 Novoseek chemical compound relationships for ST14 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
serine	84.8	202	12784999 (5), 12549907 (4), 10500122 (3), 11780337 (3) (see all 99)
ecotin	76.9	1	10500122 (1)
benzamidine	45.9	3	11696548 (1), 17388811 (1)
suramin	19.6	11	15590895 (5), 17344310 (1)
aprotinin	17	1	1562736 (1)
nitric oxide	0	1	17389401 (1)
phospholipid	0	1	15075215 (1)
lipid	0	6	17344310 (1), 16838070 (1)
calcium	0	3	15305371 (1), 19242518 (1)

Search CenterWatch for drugs/clinical trials and news about ST14

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ST14 gene:

NM_021978.3

Unigene Cluster for ST14:

Suppression of tumorigenicity 14 (colon carcinoma)

Hs.504315 [show with all ESTs]

Unigene Representative Sequence: NM_021978

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000278742(uc001qfw.3) ENST00000525779 ENST00000530532 ENST00000524718(uc010sca.1)

ENST00000530376

miRNA Products:		OriGene 3'-UTR Clone: ST14 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST14
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate ST14:
		hsa-miR-33a* hsa-miR-485-5p hsa-miR-4307 hsa-miR-27a hsa-miR-27b
		SwitchGear 3'UTR luciferase reporter plasmid: ST14 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AB030036.1 AF057145.1 AF118224.2 AF133086.1 AK302454.1 AK314173.1 BC005826.2 BC018146.1

BC030532.1 BC128597.1

20 DOTS entries:

DT.101967801 DT.446293 DT.91759239 DT.87016311 DT.100800553 DT.120726809 DT.75190369 DT.100764700

DT.97857725 DT.120726660 DT.95148082 DT.100877693 DT.120726640 DT.91759230 DT.91759237 DT.95148080

DT.95148084 DT.120726848 DT.95270653 DT.95322460

24/317 AceView cDNA sequences (see all 317):

BG468516 AW820710 BQ066710 AI199635 AW820725 BQ059215 AA343593 BX384940

CR594334 AI950613 AW263022 AA402806 BG385962 BC018146 BU957199 AI569057

AW820719 AW610195 AI017018 BC005826 AW820718 AI935905 CR620300 BG679913

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ST14 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18	^	19a	·	19b
SP1:
SP2:

ECgene alternative splicing isoforms for ST14

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ST14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGTGCGTGG

About this image

ST14 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Testis

Gut Tube

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ST14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ST14

SOURCE GeneReport for Unigene cluster: Hs.504315

SABiosciences Custom PCR Arrays for ST14

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST14

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ST14 gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ST14¹	suppression of tumorigenicity 14 (colon carcinoma)	68.41(n) 62.99(a)		419731 XM_417872.3 XP_417872.3
lizard (Anolis carolinensis)	Reptilia	ST14⁶	--	59(a)	1 ↔ 1	GL343197.1(264383-290311)
African clawed frog (Xenopus laevis)	Amphibia	AB038498.1²	--	72.28(n)		AB038498.1
zebrafish (Danio rerio)	Actinopterygii	wufl72f01²	wufl72f01	75.29(n)		334564 57088877
rice (Oryza sativa)	Liliopsida	U83834.1²	--	92.3(n)		U83834.1

ENSEMBL Gene Tree for ST14 (if available)
TreeFam Gene Tree for ST14 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ST14 gene

TMPRSS7² TMPRSS5² TMPRSS4² TMPRSS11D² TMPRSS13² TMPRSS11E² TMPRSS3² TMPRSS11B²

TMPRSS2² TMPRSS9² HPN² TMPRSS15² TMPRSS11F² TMPRSS11A² TMPRSS6²

18/85 SIMAP similar genes for ST14 using alignment to 3 protein entries: ST14_HUMAN (see all proteins) (see all similar genes):

serase-1B F12 DESC1 TMPRSS11E CELA2B TMPRSS11D

TMPRSS11F TMPRSS5 PRSS1 F9 CTRB1 CTRB2

CTRL DKFZp779M0222 OVCH1 PRSS36 PRSS55 TMPRSS11A

ST14 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78034098^1,2	F	--	125979082(+)	`CGAAAT/CGGTGG`	1	--	us2k¹		1	WA	118
rs73585170^1,2	C	--	125979165(+)	`GCATAT/CCAGTC`	1	--	us2k¹		4	WA CSA	123
rs73585171^1,2	C	--	125979241(+)	`GCTGAC/ATGACT`	1	--	us2k¹		2	CSA WA	120
rs78665341^1,2	F	--	125979640(+)	`GGAATG/ACTTGG`	1	--	us2k¹		1	WA	118
rs78299844^1,2	C	--	125979651(+)	`AGGCAC/TGGTGT`	1	--	us2k¹		2	NA	122
rs12799378^1,2	C,F	--	125979687(+)	`AGCTGG/AGCTAA`	1	--	us2k¹		4	NA	216
rs76653005^1,2		--	125979810(+)	`GATCTT/CTCTTA`	1	--	us2k¹		1	WA	118
rs7109309^1,2	C,F,A,H	--	125979861(+)	`AATGCG/ACAGGA`	1	--	us2k¹		11	NS EA NA WA	1208
rs28365808^1,2	C,F	--	125980209(+)	`ACTCCT/-TGGTG`	1	--	us2k¹		2	MN EA	1252
rs76991049^1,2	F	--	125980253(+)	`AAGTCG/TTAAGA`	1	--	us2k¹		1	WA	118

HapMap Linkage Disequilibrium report for ST14 (130029457 - 130080356 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for ST14
5 CNVs: 3869 48733 48732 48735 48734
Human Gene Mutation Database (HGMD): ST14

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ST14

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ST14 for disorders           About GeneDecksing

OMIM gene information: 606797
OMIM disorders: 610765
UniProtKB/Swiss-Prot: ST14_HUMAN, Q9Y5Y6

Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:610765]. ARIH is

a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of

hair

20/47 diseases for ST14 (see all 47): About MalaCards

colon carcinoma emery-dreifuss muscular dystrophy carcinoma prostatitis

fragile x syndrome ichthyosis color blindness microcytic anemia

bulimia nervosa hypotrichosis ichthyosis, follicular ichthyosis with hypotrichosis

intraepithelial neoplasm esophageal squamous cell carcinoma squamous cell carcinoma pancreatic ductal adenocarcinoma

malignant mesothelioma muscular dystrophy epithelial ovarian cancer ovarian cancer

2 diseases from the University of Copenhagen DISEASES database for ST14:

Adrenoleukodystrophy Fragile X syndrome

10/28 Novoseek disease relationships for ST14 gene (see all 28) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	49.2	22	16273651 (4), 18649738 (2), 17456594 (1), 19443387 (1) (see all 16)
cancer	46.1	54	15832373 (4), 20145119 (4), 19243302 (3), 17673379 (2) (see all 29)
prostate carcinoma	41.6	5	20015050 (1), 10500122 (1), 18649735 (1), 15368474 (1) (see all 5)
tumors	39.2	73	11948120 (7), 16439987 (5), 17069593 (5), 17163404 (5) (see all 29)
prostate cancer	37.7	11	18813126 (3), 18649738 (2), 16492908 (1), 15928670 (1) (see all 6)
breast cancer	34.1	32	12498394 (7), 11290548 (4), 10373425 (3), 16467405 (2) (see all 14)
carcinoma	33.6	16	16820046 (3), 11290548 (2), 16439987 (2), 19940125 (2) (see all 10)
pathological processes	32.4	1	17940283 (1)
prostatic adenocarcinoma	30.8	3	16492908 (1), 18338334 (1), 16467405 (1)
cervical carcinoma	27.8	9	14584072 (5), 12926053 (1), 16021568 (1)

Genetic Association Database (GAD): ST14
Human Genome Epidemiology (HuGE) Navigator: ST14 (7 documents)

Export disorders for ST14 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ST14 gene, integrated from 9 sources (see all 199):
(articles sorted by number of sources associating them with ST14)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity. (PubMed id 10373424)^{1, 2, 3, 9} Lin C.Y.... Dickson R.B. (1999)
The novel serine protease tumor-associated differentially expressed gene-15 (matriptase/MT-SP1) is highly overexpressed in cervical carcinoma. (PubMed id 14584072)^{1, 4, 9} Santin A.D....Pecorelli S. (2003)
Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk. (PubMed id 10373425)^{1, 2, 9} Lin C.Y.... Dickson R.B. (1999)
Inhibition of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinase. (PubMed id 14747469)^{1, 7, 9} Suzuki M....Terao T. (2004)
Protein interaction analysis of ST14 domains and their point and deletion mutants. (PubMed id 16407223)^{1, 2, 9} Ge W.... Zheng S. (2006)
Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue. (PubMed id 10500122)^{1, 2, 9} Takeuchi T.... Craik C.S. (1999)
Assignment1 of human putative tumor suppressor genes ST13 (alias SNC6) and ST14 (alias SNC19) to human chromosome bands 22q13 and 11q24-->q25 by in situ hybridization. (PubMed id 9925927)^{1, 3, 9} Zhang Y....Zheng S. (1998)
Adhesion signaling by a novel mitotic substrate of src kinases. (PubMed id 16007225)^{1, 2, 9} Bhatt A.S.... Moasser M.M. (2005)
Autosomal recessive ichthyosis with hypotrichosis caused by a mutation in ST14, encoding type II transmembrane serine protease matriptase. (PubMed id 17273967)^{1, 2} Basel-Vanagaite L.... Shohat M. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6768	HGNC: 11344	AceView: ST14	Ensembl:ENSG00000149418	euGenes: HUgn6768
ECgene: ST14	H-InvDB: ST14

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ST14	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ST14	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ST14 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ST14 gene:
Search GeneIP for patents involving ST14

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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ST14 Gene

suppression of tumorigenicity 14 (colon carcinoma)

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ST14 (Gene Symbol)
Suppression Of Tumorigenicity 14 (Colon Carcinoma)
MT-SP1
PRSS14
SNC19
HAI
TMPRSS14
Membrane-Type Serine Protease 1
Serine Protease 14
Serine Protease TADG-15
Tumor-Associated Differentially-Expressed Gene 15 Protein
TADG15
EC 3.4.21.109
MTSP1
Prostamin
Suppression Of Tumorigenicity 14 (Colon Carcinoma, Matriptase, Epithin)
Suppressor Of Tumorigenicity 14 Protein
Tumor Associated Differentially Expressed Gene 15 Protein
Matriptase
Prostamin
EC 3.4.21

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ST14 Gene

suppression of tumorigenicity 14 (colon carcinoma)

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