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Aliases for ST14 Gene

Aliases for ST14 Gene

  • Suppression Of Tumorigenicity 14 2 3 5
  • Suppression Of Tumorigenicity 14 (Colon Carcinoma) 2 3
  • Membrane-Type Serine Protease 1 3 4
  • Serine Protease TADG-15 3 4
  • Serine Protease 14 3 4
  • EC 4 58
  • Matriptase 2 4
  • Prostamin 3 4
  • PRSS14 3 4
  • MT-SP1 3 4
  • TADG15 3 4
  • SNC19 3 4
  • Suppression Of Tumorigenicity 14 (Colon Carcinoma, Matriptase, Epithin) 3
  • Tumor Associated Differentially Expressed Gene 15 Protein 3
  • Tumor-Associated Differentially-Expressed Gene 15 Protein 4
  • Suppressor Of Tumorigenicity 14 Protein 3
  • EC 3.4.21 58
  • TMPRSS14 3
  • Epithin 2
  • ARCI11 3
  • MTSP1 3
  • HAI 3

External Ids for ST14 Gene

Previous HGNC Symbols for ST14 Gene

  • PRSS14

Previous GeneCards Identifiers for ST14 Gene

  • GC11P132030
  • GC11P131542
  • GC11P130063
  • GC11P129567
  • GC11P129534
  • GC11P125980

Summaries for ST14 Gene

Entrez Gene Summary for ST14 Gene

  • The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST14 Gene

ST14 (Suppression Of Tumorigenicity 14) is a Protein Coding gene. Diseases associated with ST14 include Ichthyosis, Congenital, Autosomal Recessive 11 and St14-Related Autosomal Recessive Congenital Ichthyosis. Among its related pathways are Keratinization and MicroRNAs in cancer. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is TMPRSS6.

UniProtKB/Swiss-Prot for ST14 Gene

  • Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing.

Additional gene information for ST14 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST14 Gene

Genomics for ST14 Gene

Regulatory Elements for ST14 Gene

Enhancers for ST14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H130143 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -13.8 -13815 4.8 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 FOS SP5 MXD4 REST ST14 PIR61423
GH11H130120 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -34.2 -34178 10.3 PKNOX1 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 FOS ATF7 REST APLP2 PRDM10 LINC00167 NFRKB ST14 PIR61423 ENSG00000274197 GC11M130115
GH11H130165 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +7.5 7500 3.8 TBP PKNOX1 JUN MAX BATF FOSL1 POLR2A FOSL2 ZNF600 FOS ST14 ADAMTS8 LOC103611081 LINC02551 PRDM10 GC11P130253
GH11H130159 1.4 Ensembl ENCODE dbSUPER 12.1 +2.4 2359 5.5 ELF3 ARID4B DMAP1 ZBTB40 RAD21 RARA ZNF121 RCOR1 THAP11 CEBPB ST14 ADAMTS8 GC11P130253
GH11H130177 1.5 Ensembl ENCODE dbSUPER 10.2 +21.3 21308 6.6 PKNOX1 FOXA2 ATF1 DMAP1 YY1 FOS ATF7 RUNX3 SP5 MXD4 ST14 GC11P130253
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ST14 on UCSC Golden Path with GeneCards custom track

Promoters for ST14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000047072 738 1001 SUZ12 NRF1 DPF2 E2F1 GATA3 POLR2A ZFX IKZF2 SPI1 EZH2

Genomic Locations for ST14 Gene

Genomic Locations for ST14 Gene
50,815 bases
Plus strand

Genomic View for ST14 Gene

Genes around ST14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST14 Gene

Proteins for ST14 Gene

  • Protein details for ST14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Suppressor of tumorigenicity 14 protein
    Protein Accession:
    Secondary Accessions:
    • Q9BS01
    • Q9H3S0
    • Q9HB36
    • Q9HCA3

    Protein attributes for ST14 Gene

    855 amino acids
    Molecular mass:
    94770 Da
    Quaternary structure:
    • Interacts with CDCP1. May interact with TMEFF1.

    Three dimensional structures from OCA and Proteopedia for ST14 Gene

neXtProt entry for ST14 Gene

Selected DME Specific Peptides for ST14 Gene


Post-translational modifications for ST14 Gene

  • Glycosylation at posLast=109109, posLast=209209, posLast=302302, posLast=485485, and Asn772
  • Modification sites at PhosphoSitePlus

Other Protein References for ST14 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ST14 (Matriptase/ST14)
  • Cell Signaling Technology (CST) Antibodies for ST14 (ST14)
  • Abcam antibodies for ST14

Domains & Families for ST14 Gene

Gene Families for ST14 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ST14 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with ST14: view

Function for ST14 Gene

Molecular function for ST14 Gene

GENATLAS Biochemistry:
suppression of tumorigenicity 14,colon carcinoma,see TSG11F
UniProtKB/Swiss-Prot CatalyticActivity:
Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position.
UniProtKB/Swiss-Prot Function:
Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing.

Enzyme Numbers (IUBMB) for ST14 Gene

Gene Ontology (GO) - Molecular Function for ST14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity TAS --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IDA,TAS 19911255
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ST14: view
genes like me logo Genes that share phenotypes with ST14: view

Human Phenotype Ontology for ST14 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ST14 Gene

MGI Knock Outs for ST14:

Animal Model Products

miRNA for ST14 Gene

miRTarBase miRNAs that target ST14

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for ST14 Gene

Localization for ST14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST14 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST14 gene
Compartment Confidence
plasma membrane 5
extracellular 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ST14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10831593
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ST14: view

Pathways & Interactions for ST14 Gene

genes like me logo Genes that share pathways with ST14: view

Pathways by source for ST14 Gene

1 Cell Signaling Technology pathway for ST14 Gene
1 KEGG pathway for ST14 Gene

Gene Ontology (GO) - Biological Process for ST14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure IEA --
GO:0006508 proteolysis TAS,IDA 19911255
GO:0030216 keratinocyte differentiation IMP 18843291
GO:0060672 epithelial cell morphogenesis involved in placental branching IEA --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with ST14: view

No data available for SIGNOR curated interactions for ST14 Gene

Drugs & Compounds for ST14 Gene

(7) Drugs for ST14 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Urokinase Approved, Investigational, Withdrawn Pharma Target 0
benzamidine Experimental Pharma Target 0

(3) Additional Compounds for ST14 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ST14: view

Transcripts for ST14 Gene

Unigene Clusters for ST14 Gene

Suppression of tumorigenicity 14 (colon carcinoma):
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST14 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b

Relevant External Links for ST14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ST14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST14 Gene

This gene is overexpressed in Colon - Transverse (x9.9), Esophagus - Mucosa (x5.9), and Small Intestine - Terminal Ileum (x4.5).

Protein differential expression in normal tissues from HIPED for ST14 Gene

This gene is overexpressed in Cervix (12.7) and Rectum (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ST14 Gene

NURSA nuclear receptor signaling pathways regulating expression of ST14 Gene:


SOURCE GeneReport for Unigene cluster for ST14 Gene:


Evidence on tissue expression from TISSUES for ST14 Gene

  • Blood(4.3)
  • Intestine(4.3)
  • Muscle(4.1)
  • Lung(2.9)
  • Skin(2.5)
  • Kidney(2.4)
  • Pancreas(2.3)
  • Stomach(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ST14 Gene

Germ Layers:
  • ectoderm
  • mesoderm
  • integumentary
  • nervous
Head and neck:
  • brain
  • eye
  • eyelid
  • face
  • forehead
  • head
  • hair
  • skin
genes like me logo Genes that share expression patterns with ST14: view

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ST14 Gene

Orthologs for ST14 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ST14 33 34
  • 98.95 (n)
(Canis familiaris)
Mammalia ST14 33 34
  • 85.33 (n)
(Mus musculus)
Mammalia St14 33 16 34
  • 83.16 (n)
(Rattus norvegicus)
Mammalia St14 33
  • 82.85 (n)
(Bos Taurus)
Mammalia ST14 33 34
  • 81.75 (n)
(Monodelphis domestica)
Mammalia ST14 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia ST14 34
  • 69 (a)
(Gallus gallus)
Aves ST14 33 34
  • 67.58 (n)
(Anolis carolinensis)
Reptilia ST14 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia st14 33
  • 58.06 (n)
(Danio rerio)
Actinopterygii st14a 33 34
  • 54.95 (n)
ST14 (2 of 3) 34
  • 45 (a)
st14b 34
  • 44 (a)
wufl72f01 33
fruit fly
(Drosophila melanogaster)
Insecta CG11824 35
  • 41 (a)
CG4914 35
  • 39 (a)
CG18735 35
  • 38 (a)
CG9294 35
  • 38 (a)
Sb 35
  • 38 (a)
Try29F 35
  • 38 (a)
CG18065 35
  • 37 (a)
CG4386 35
  • 37 (a)
CG5197 35
  • 35 (a)
CG7432 35
  • 35 (a)
CG1299 35
  • 34 (a)
CG8213 35
  • 34 (a)
EG:80H7.3 35
  • 34 (a)
(Caenorhabditis elegans)
Secernentea C07G1.1 35
  • 37 (a)
Species where no ortholog for ST14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ST14 Gene

Gene Tree for ST14 (if available)
Gene Tree for ST14 (if available)

Paralogs for ST14 Gene

Variants for ST14 Gene

Sequence variations from dbSNP and Humsavar for ST14 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs137852931 Pathogenic, Ichthyosis, congenital, autosomal recessive 11 (ARCI11) [MIM:602400] 130,209,734(+) GCTGG(A/C/G)GAGAC reference, missense
rs137852932 Pathogenic 130,159,982(+) ACCAT(A/G)GGGAG reference, missense
rs587777262 Pathogenic 130,208,685(+) TGGAG(A/G)TAAGC splice-donor-variant
rs587777263 Pathogenic 130,208,449(+) GGCTT(-/G)CACGA reference, frameshift-variant
rs1000082274 -- 130,172,066(+) ATTTC(A/C)AGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST14 Gene

Variant ID Type Subtype PubMed ID
nsv832295 CNV gain 17160897
nsv556565 CNV loss 21841781
nsv517199 CNV loss 19592680
nsv478551 CNV novel sequence insertion 20440878
nsv1143696 CNV deletion 24896259
nsv1051470 CNV gain 25217958
esv2759871 CNV loss 17122850
dgv3e24 CNV gain 17666407

Variation tolerance for ST14 Gene

Residual Variation Intolerance Score: 84.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.71; 78.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ST14 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST14 Gene

Disorders for ST14 Gene

MalaCards: The human disease database

(13) MalaCards diseases for ST14 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ichthyosis, congenital, autosomal recessive 11
  • autosomal recessive congenital ichthyosis 11
st14-related autosomal recessive congenital ichthyosis
  • ichthyosis, congenital, autosomal recessive 11
ichthyosis, follicular
  • follicular ichthyosis
ichthyosis, congenital, autosomal recessive 7
  • autosomal recessive congenital ichthyosis 7
autosomal recessive congenital ichthyosis
  • arci
- elite association - COSMIC cancer census association via MalaCards
Search ST14 in MalaCards View complete list of genes associated with diseases


  • Ichthyosis, congenital, autosomal recessive 11 (ARCI11) [MIM:602400]: A form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. {ECO:0000269 PubMed:17273967, ECO:0000269 PubMed:18843291}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ST14

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ST14: view

No data available for Genatlas for ST14 Gene

Publications for ST14 Gene

  1. Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity. (PMID: 10373424) Lin CY … Dickson RB (The Journal of biological chemistry 1999) 2 3 4 22 60
  2. Ichthyosis, follicular atrophoderma, and hypotrichosis caused by mutations in ST14 is associated with impaired profilaggrin processing. (PMID: 18843291) Alef T … Hennies HC (The Journal of investigative dermatology 2009) 3 4 22 60
  3. Protein interaction analysis of ST14 domains and their point and deletion mutants. (PMID: 16407223) Ge W … Zheng S (The Journal of biological chemistry 2006) 3 4 22 60
  4. Adhesion signaling by a novel mitotic substrate of src kinases. (PMID: 16007225) Bhatt AS … Moasser MM (Oncogene 2005) 3 4 22 60
  5. The novel serine protease tumor-associated differentially expressed gene-15 (matriptase/MT-SP1) is highly overexpressed in cervical carcinoma. (PMID: 14584072) Santin AD … Pecorelli S (Cancer 2003) 3 22 45 60

Products for ST14 Gene

Sources for ST14 Gene

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