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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ST13 Gene

protein-coding   GIFtS: 60
GCID: GC22M041220

Suppression Of Tumorigenicity 13 (Colon Carcinoma) (Hsp7...

(Previous name: suppression of tumorigenicity 13 (colon carcinoma) (Hsp7...)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Suppression Of Tumorigenicity 13 (Colon Carcinoma) (Hsp70 Interacting
Protein)1 2
     P482 5
Progesterone Receptor-Associated P48 Protein1 2 3     Suppression Of Tumorigenicity 13 (Colon Carcinoma) (Hsp70-Interacting
Protein)1
Aging-Associated Protein 22 3     FAM10A42
Putative Tumor Suppressor ST132 3     HSPABP2
Renal Carcinoma Antigen NY-REN-332 3     HSPABP12
Suppression Of Tumorigenicity 13 Protein2 3     PRO07862
AAG22 3     Heat Shock 70kD Protein Binding Protein2
FAM10A12 3     Hsc70-Interacting Protein2
HIP2 3     Hsp70-Interacting Protein2
SNC62 3     Hip3
HOP2 5     Protein FAM10A13

External Ids:    HGNC: 113431   Entrez Gene: 67672   Ensembl: ENSG000001003807   OMIM: 6067965   UniProtKB: P505023   

Export aliases for ST13 gene to outside databases

Previous GC identifers: GC22M037835 GC22M039463 GC22M039545


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ST13 Gene:
The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins
HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor,
which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be
downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative
splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq, Jun 2013)

GeneCards Summary for ST13 Gene: 
ST13 (suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)) is a protein-coding gene. Diseases associated with ST13 include yellow fever, and malaria. GO annotations related to this gene include unfolded protein binding and identical protein binding.

UniProtKB/Swiss-Prot: F10A1_HUMAN, P50502
Function: One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the
HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through
its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By
similarity)

Gene Wiki entry for ST13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ST13 gene promoter:
         Elk-1   POU3F2   HNF-1A   Evi-1   C/EBPalpha   AREB6   Pax-3   PPAR-gamma1   HNF-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ST13 promoter sequence
   Search SABiosciences Chromatin IP Primers for ST13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2

ST13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST13 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M041220:  view genomic region     (about GC identifiers)

Start:
41,220,539 bp from pter      End:
41,253,026 bp from pter
Size:
32,488 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F10A1_HUMAN, P50502 (See protein sequence)
Recommended Name: Hsc70-interacting protein  
Size: 369 amino acids; 41332 Da
Subunit: Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90 (By similarity). Interacts (via the
C-terminus 303- 319 AA) with GRK5
Subcellular location: Cytoplasm (By similarity)
1 PDB 3D structure from and Proteopedia for ST13:
1UZS (3D)    
Secondary accessions: O14999 Q2TU77

Explore the universe of human proteins at neXtProt for ST13: NX_P50502

Explore proteomics data for ST13 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P50502

  • ST13 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ST13 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001265518.1  NP_003923.2  

    ENSEMBL proteins: 
     ENSP00000216218   ENSP00000397062   ENSP00000412049   ENSP00000392067  

    Human Recombinant Protein Products for ST13: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene MassSpec for ST13 
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    GenScript Custom Purified and Recombinant Proteins Services for ST13
    Novus Biologicals ST13 Proteins
    Novus Biologicals ST13 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ST13
    Cloud-Clone Corp. Proteins for ST13 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS8721986
    GO:0005829cytosol IEA--
    GO:0043234protein complex IEA--

    ST13 for ontologies           About GeneDecksing



    ST13 Antibody Products: 
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    Novus Biologicals ST13 Antibodies
    Abcam antibodies for ST13
    Cloud-Clone Corp. Antibodies for ST13 
    ThermoFisher Antibody for ST13
    LSBio Antibodies in human, mouse, rat for ST13 

    Assay Products for ST13: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ST13 
    Cloud-Clone Corp. CLIAs for ST13


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TTC: Tetratricopeptide (TTC) repeat domain containing

    5/6 InterPro protein domains (see all 6):
     IPR006636 STI1_HS-bd
     IPR001440 TPR-1
     IPR011990 TPR-like_helical
     IPR013105 TPR_2
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry P50502

    ProtoNet protein and cluster: P50502

    1 Blocks protein domain: IPB006636 Heat shock chaperonin-binding

    UniProtKB/Swiss-Prot: F10A1_HUMAN, P50502
    Similarity: Belongs to the FAM10 family
    Similarity: Contains 1 STI1 domain
    Similarity: Contains 3 TPR repeats


    ST13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: F10A1_HUMAN, P50502
    Function: One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the
    HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through
    its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By
    similarity)

         Genatlas biochemistry entry for ST13:
    suppression of tumorigenicity 13,colon carcinoma,see TSG22C

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0019904protein domain specific binding IEA--
    GO:0030544Hsp70 protein binding IEA--
    GO:0030674protein binding, bridging TAS8721986
    GO:0032403protein complex binding IEA--
         
    ST13 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ST13:
     Decreased TP53 protein express 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ST13 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ST13

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ST13 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ST13 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST13
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate ST13 (see all 29):
    hsa-miR-3149 hsa-miR-4291 hsa-miR-3200-5p hsa-miR-3607-3p hsa-miR-520d-5p hsa-miR-137 hsa-miR-509-5p hsa-miR-548s
    SwitchGear 3'UTR luciferase reporter plasmidST13 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ST13 (NM_003932)
    Browse Sino Biological Human cDNA Clones
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                         Customized lentivirus expression plasmids for stable overexpression of ST13 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST13


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ST13 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics
    Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics


    1 PharmGKB Pathway for ST13
        Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ST13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/71 Interacting proteins for ST13 (P505021, 2, 3 ENSP000002162184) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=3 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=3 
    ENSG00000215328P081073I2D: score=3 
    ENSG00000224501P081073I2D: score=3 
    ENSG00000231555P081073I2D: score=3 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS8721986
    GO:0051260protein homooligomerization IEA--
    GO:0061084negative regulation of protein refolding IEA--
    GO:0070389chaperone cofactor-dependent protein refolding IEA--

    ST13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ST13 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ST13 (F10A1)

    5 Novoseek inferred chemical compound relationships for ST13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    steroid 52.7 14 10702249 (2), 17323428 (1), 8939864 (1), 12093808 (1) (see all 8)
    progesterone 46.1 8 8721986 (3), 10630990 (1), 10364185 (1), 14627198 (1) (see all 5)
    prostacyclin 43.5 6 17164137 (2), 20395296 (1), 11961139 (1), 17704830 (1) (see all 5)
    atp 40.1 9 10364185 (1), 11809754 (1), 12093808 (1), 12563018 (1) (see all 6)
    adp 5.42 2 9321400 (1), 7585962 (1)

    Search CenterWatch for drugs/clinical trials and news about ST13 / F10A1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ST13 gene (2 alternative transcripts): 
    NM_001278589.1  NM_003932.4  

    Unigene Cluster for ST13:

    Suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
    Hs.712713  [show with all ESTs]
    Unigene Representative Sequence: NM_003932
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216218(uc003aze.3 uc011aow.2) ENST00000480048 ENST00000455824
    ENST00000413424 ENST00000411695 ENST00000495652

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST13
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate ST13 (see all 29):
    hsa-miR-3149 hsa-miR-4291 hsa-miR-3200-5p hsa-miR-3607-3p hsa-miR-520d-5p hsa-miR-137 hsa-miR-509-5p hsa-miR-548s
    SwitchGear 3'UTR luciferase reporter plasmidST13 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ST13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST13
    Clone
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    OriGene clones in human, mouse for ST13 (see all 7)
    OriGene ORF clones in mouse, rat for ST13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ST13 (NM_003932)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST13
    Sirion Biotech Customized lentivirus for stable overexpression of ST13 
                         Customized lentivirus expression plasmids for stable overexpression of ST13 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ST13
    OriGene qSTAR qPCR primer pairs in human, mouse for ST13
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ST13
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ST13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST13

    Additional mRNA sequence: 

    AF116650.1 AK130770.1 AK303530.1 AK312399.1 AK316155.1 AY513286.1 AY826824.1 AY826825.1 
    BC015317.1 BC052982.1 BC071629.1 BC101206.1 BC101207.2 BC101208.1 BC107148.1 BC121107.1 
    BC121108.1 BC139724.1 CR456586.1 U17714.1 U28918.1 

    24/55 DOTS entries (see all 55):

    DT.99998054  DT.100892017  DT.100000399  DT.456282  DT.92464568  DT.92464561  DT.95149390  DT.85101734 
    DT.120650009  DT.100892054  DT.120649901  DT.92343743  DT.92464548  DT.100034556  DT.100653922  DT.100686762 
    DT.100770617  DT.100892013  DT.100892025  DT.100892026  DT.100892033  DT.100892034  DT.92464564  DT.95149407 

    24/818 AceView cDNA sequences (see all 818):

    AU117682 CA424055 BQ961449 BU508735 AA393257 BQ772590 C00124 BM697051 
    BQ640747 BU178256 AL695330 T34287 AK130770 AU132227 AI738918 AI708473 
    BM982995 BX403413 BE925948 BX114455 CB135262 CD365025 BQ051171 BG427599 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ST13 expression in normal human tissues (normalized intensities)      ST13 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGATCCAG
    ST13 Expression
    About this image


    ST13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See ST13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ST13

    SOURCE GeneReport for Unigene cluster: Hs.712713
        SABiosciences Expression via Pathway-Focused PCR Array including ST13: 
              Cellular Stress Responses in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ST13 gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St131 , 5 suppression of tumorigenicity 131, 5 90.49(n)1
    94.57(a)1
      15 (38.07 cM)5
    703561  NM_133726.21  NP_598487.11 
     813636695 
    chicken
    (Gallus gallus)
    Aves ST131 suppression of tumorigenicity 13 (colon carcinoma) more 80.06(n)
    84.27(a)
      418003  NM_001030757.1  NP_001025928.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    ST136
    Uncharacterized protein
    79(a)
    51(a)
    many → 1
    many → 1
    5(25992119-26014076)
    GL343345.1(212806-213594)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.48142 Xenopus laevis transcribed sequence with weak similarity more 77.57(n)    BQ723839.1 
    zebrafish
    (Danio rerio)
    Actinopterygii st132 suppression of tumorigenicity 13 (colon carcinoma) more 74.98(n)   327184  BC063322.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG29473
    HIP-R1
    chaperone3
    Hsc/Hsp70-interacting protein related1
    37(a)3
    52.94(n)1
    47.8(a)1
      3F13
    313351  NM_166988.41  NP_726885.11 
    worm
    (Caenorhabditis elegans)
    Secernentea hip-11 Protein HIP-1 52.86(n)
    50.42(a)
      176794  NM_067410.2  NP_499811.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HIP11 HSP70-interacting protein 1 58.97(n)
    51.65(a)
      828363  NM_118393.2  NP_567663.1 
    rice
    (Oryza sativa)
    Liliopsida AK102264.12   -- 74.8(n)    AK102264.1 


    ENSEMBL Gene Tree for ST13 (if available)
    TreeFam Gene Tree for ST13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ST13 gene
    2 SIMAP similar genes for ST13 using alignment to 7 protein entries:     F10A1_HUMAN (see all proteins):
    ST13P5    ST13P4

    ST13 for paralogs           About GeneDecksing


    5/23 Pseudogenes.org Pseudogenes for ST13 (see all 23)
    PGOHUM00000238909 PGOHUM00000242489 PGOHUM00000242862 PGOHUM00000239482 PGOHUM00000239567


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/656 SNPs in ST13 are shown (see all 656)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2012236741,2
    --41220136(+) GGGGT-/GGGGGG 1 -- ds50010--------
    rs357018641,2
    C--41220350(+) CTCCT-/CACCACCT 1 -- cds10--------
    rs1502922111,2
    --41220441(+) GAAACC/TGTATT 1 -- ds50010--------
    rs1823168451,2
    --41220561(+) AATGTA/GTATTA 1 -- ds50010--------
    rs797634221,2
    F--41220588(+) AAAAGC/GACAGG 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs782657721,2
    C--41220684(+) ATAAGG/TAATCC 1 -- ut310--------
    rs57580981,2
    C,F,H--41220756(+) TACACA/GTTAAC 1 -- ut31 ese316Minor allele frequency- G:0.11NS EA NA WA 1230
    rs1877313421,2
    --41221135(+) GAATGC/TACAAC 1 -- ut310--------
    rs1448795391,2
    C--41221318(+) AAAAAA/GATCGG 1 -- ut310--------
    rs1490378121,2
    --41221669(+) GTCTTC/TAGCTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ST13 (41220539 - 41253026 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ST13:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv4978n71CNV Loss21882294
    nsv915112CNV Loss21882294
    nsv834206CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606796    OMIM disorders: --

    9 diseases for ST13:    About MalaCards
    yellow fever    malaria    cystic fibrosis    renal cell carcinoma
    parkinson's disease    colorectal cancer    pancreatic cancer    pancreatitis
    alzheimer's disease


    ST13 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for ST13 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 52.9 14 10330192 (1), 17323428 (1), 18052042 (1), 10567384 (1) (see all 10)
    tumors 3.42 1 9925927 (1)


    Export disorders for ST13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ST13 gene, integrated from 9 sources (see all 117):
    (articles sorted by number of sources associating them with ST13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein. (PubMed id 8721986)1, 2, 3, 9 Prapapanich V.... Smith D.F. (1996)
    2. Assignment1 of human putative tumor suppressor genes ST13 (alias SNC6) and ST14 (alias SNC19) to human chromosome bands 22q13 and 11q24-->q25 by in situ hybridization. (PubMed id 9925927)1, 3, 9 Zhang Y....Zheng S. (1998)
    3. G protein-coupled receptor kinase 5 phosphorylation of Hip regulates internalization of the chemokine receptor CXCR4. (PubMed id 21728385)1, 2 Barker B.L. and Benovic J.L. (2011)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (1999)
    7. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    8. Characterization of colorectal-cancer-related cDNA clones obtained by subtractive hybridization screening. (PubMed id 9292708)1, 2 Cao J.... Zheng S. (1997)
    9. Differential expression of HSU17714 gene in colorectal cancer and normal colonic mucosa. (PubMed id 9387309)1, 2 Mo Y.... Shen D. (1996)
    10. Proteolysis of HIP during apoptosis occurs within a region similar to the BID loop. (PubMed id 17013759)1, 9 Caruso J.A. and Reiners J.J. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6767 HGNC: 11343 AceView: ST13 Ensembl:ENSG00000100380 euGenes: HUgn6767
    ECgene: ST13 H-InvDB: ST13

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ST13 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ST13 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ST13 gene:
    Search GeneIP for patents involving ST13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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