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ST13 Gene

protein-coding   GIFtS: 57
GCID: GC22M041220

Suppression Of Tumorigenicity 13 (Colon Carcinoma) (Hsp7...

(Previous name: suppression of tumorigenicity 13 (colon carcinoma) (Hsp7...)
  Search for ST13
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Suppression Of Tumorigenicity 13 (Colon Carcinoma) (Hsp70 Interacting
Protein)1 2
     P482 5
Progesterone Receptor-Associated P48 Protein1 2 3     Suppression Of Tumorigenicity 13 (Colon Carcinoma) (Hsp70-Interacting
Protein)1
Aging-Associated Protein 22 3     FAM10A42
Putative Tumor Suppressor ST132 3     HSPABP2
Renal Carcinoma Antigen NY-REN-332 3     HSPABP12
Suppression Of Tumorigenicity 13 Protein2 3     PRO07862
AAG22 3     Heat Shock 70kD Protein Binding Protein2
FAM10A12 3     Hsc70-Interacting Protein2
HIP2 3     Hsp70-Interacting Protein2
SNC62 3     Hip3
HOP2 5     Protein FAM10A13

External Ids:    HGNC: 113431   Entrez Gene: 67672   Ensembl: ENSG000001003807   OMIM: 6067965   UniProtKB: P505023   

Export aliases for ST13 gene to outside databases

Previous GC identifers: GC22M037835 GC22M039463 GC22M039545


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ST13 Gene:
The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins
HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor,
which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be
downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative
splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq, Jun 2013)

GeneCards Summary for ST13 Gene:
ST13 (suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)) is a protein-coding gene. GO annotations related to this gene include protein complex binding and identical protein binding.

UniProtKB/Swiss-Prot: F10A1_HUMAN, P50502
Function: One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the
HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through
its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By
similarity)

Gene Wiki entry for ST13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ST13 gene promoter:
         Elk-1   POU3F2   HNF-1A   Evi-1   C/EBPalpha   AREB6   Pax-3   PPAR-gamma1   HNF-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ST13 promoter sequence
   Search Chromatin IP Primers for ST13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ST13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2

ST13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST13 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M041220:  view genomic region     (about GC identifiers)

Start:
41,220,539 bp from pter      End:
41,253,026 bp from pter
Size:
32,488 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: F10A1_HUMAN, P50502 (See protein sequence)
Recommended Name: Hsc70-interacting protein  
Size: 369 amino acids; 41332 Da
Subunit: Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90 (By similarity). Interacts (via the
C-terminus 303- 319 AA) with GRK5
1 PDB 3D structure from and Proteopedia for ST13:
1UZS (3D)    
Secondary accessions: O14999 Q2TU77

Explore the universe of human proteins at neXtProt for ST13: NX_P50502

Explore proteomics data for ST13 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys17, Lys41, Lys142, Lys153, Lys160, Lys163, Lys186, Lys353, Lys360, Lys364
  • Modification sites at PhosphoSitePlus

  • See ST13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001265518.1  NP_003923.2  

    ENSEMBL proteins: 
     ENSP00000216218   ENSP00000397062   ENSP00000412049   ENSP00000392067  

    ST13 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for ST13
    OriGene Custom Protein Services for ST13
    GenScript Custom Purified and Recombinant Proteins Services for ST13
    Novus Biologicals ST13 Proteins
    Novus Biologicals ST13 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ST13
    Cloud-Clone Corp. Proteins for ST13

     
    Search eBioscience for Proteins for ST13 

    ST13 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for ST13  (HIP)
    OriGene Antibodies for ST13
    OriGene Custom Antibody Services for ST13
    Novus Biologicals ST13 Antibodies
    Search for Antibodies for ST13 at Abcam
    Cloud-Clone Corp. Antibodies for ST13
    ThermoFisher Antibody for ST13
    LSBio Antibodies in human, mouse, rat for ST13

    ST13 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ST13
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ST13
    Cloud-Clone Corp. CLIAs for ST13
    Search eBioscience for ELISAs for ST13 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR006636 STI1_HS-bd
     IPR001440 TPR_1
     IPR011990 TPR-like_helical
     IPR013105 TPR_2
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry P50502

    ProtoNet protein and cluster: P50502

    1 Blocks protein domain: IPB006636 Heat shock chaperonin-binding

    UniProtKB/Swiss-Prot: F10A1_HUMAN, P50502
    Similarity: Belongs to the FAM10 family
    Similarity: Contains 1 STI1 domain
    Similarity: Contains 3 TPR repeats


    Find genes that share domains with ST13           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: F10A1_HUMAN, P50502
    Function: One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the
    HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through
    its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By
    similarity)

         Genatlas biochemistry entry for ST13:
    suppression of tumorigenicity 13,colon carcinoma,see TSG22C

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0019904protein domain specific binding IEA--
    GO:0030544Hsp70 protein binding IEA--
    GO:0030674protein binding, bridging TAS8721986
    GO:0032403protein complex binding IEA--
         
    Find genes that share ontologies with ST13           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ST13:
     Decreased TP53 protein express 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ST13
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ST13

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ST13
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ST13

    miRNA
    Products:
        
    miRTarBase miRNAs that target ST13:
    hsa-mir-186-5p (MIRT045078), hsa-let-7b-5p (MIRT052020), hsa-mir-183-5p (MIRT047118)

    Block miRNA regulation of human, mouse, rat ST13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ST13 (see all 29):
    hsa-miR-3149 hsa-miR-4291 hsa-miR-3200-5p hsa-miR-3607-3p hsa-miR-520d-5p hsa-miR-137 hsa-miR-509-5p hsa-miR-548s
    SwitchGear 3'UTR luciferase reporter plasmidST13 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ST13
    Predesigned siRNA for gene silencing in human, mouse, rat ST13

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ST13

    Clone
    Products:
         
    OriGene clones in human, mouse for ST13 (see all 6)
    OriGene ORF clones in mouse, rat for ST13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ST13 (NM_003932)
    Sino Biological Human cDNA Clone for ST13
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST13

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ST13
    Browse ESI BIO Cell Lines and PureStem Progenitors for ST13 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST13


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    F10A1_HUMAN, P50502: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IEA--
    GO:0043234protein complex IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with ST13           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ST13 About    
    See pathways by source

    SuperPathContained pathways About
    1Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics
    Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ST13
        HOP Signaling


    1 PharmGKB Pathway for ST13
        Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics

        Pathway & Disease-focused RT2 Profiler PCR Array including ST13: 
              Cellular Stress Responses in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ST13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ST13 (P505021, 2, 3 ENSP000002162184) via UniProtKB, MINT, STRING, and/or I2D (see all 101)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=3 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=3 
    ENSG00000215328P081073I2D: score=3 
    ENSG00000224501P081073I2D: score=3 
    ENSG00000231555P081073I2D: score=3 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS8721986
    GO:0051260protein homooligomerization IEA--
    GO:0061084negative regulation of protein refolding IEA--
    GO:0070389chaperone cofactor-dependent protein refolding IEA--

    Find genes that share ontologies with ST13           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ST13 (F10A1)

    5 Novoseek inferred chemical compound relationships for ST13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    steroid 52.7 14 10702249 (2), 17323428 (1), 8939864 (1), 12093808 (1) (see all 8)
    progesterone 46.1 8 8721986 (3), 10630990 (1), 10364185 (1), 14627198 (1) (see all 5)
    prostacyclin 43.5 6 17164137 (2), 20395296 (1), 11961139 (1), 17704830 (1) (see all 5)
    atp 40.1 9 10364185 (1), 11809754 (1), 12093808 (1), 12563018 (1) (see all 6)
    adp 5.42 2 9321400 (1), 7585962 (1)



    Find genes that share compounds with ST13           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ST13 gene (2 alternative transcripts): 
    NM_001278589.1  NM_003932.4  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216218(uc003aze.3 uc011aow.2) ENST00000480048 ENST00000455824
    ENST00000413424 ENST00000411695 ENST00000495652
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ST13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ST13 (see all 29):
    hsa-miR-3149 hsa-miR-4291 hsa-miR-3200-5p hsa-miR-3607-3p hsa-miR-520d-5p hsa-miR-137 hsa-miR-509-5p hsa-miR-548s
    SwitchGear 3'UTR luciferase reporter plasmidST13 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ST13
    Predesigned siRNA for gene silencing in human, mouse, rat ST13
    Clone
    Products:
         
    OriGene clones in human, mouse for ST13 (see all 6)
    OriGene ORF clones in mouse, rat for ST13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ST13 (NM_003932)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST13
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ST13
    OriGene qSTAR qPCR primer pairs in human, mouse for ST13
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ST13
      QuantiTect SYBR Green Assays in human, mouse, rat ST13
      QuantiFast Probe-based Assays in human, mouse, rat ST13

    Selected AceView cDNA sequences (see all 818):

    BC052982 BQ216782 BQ427957 AI148155 CN483302 AA729814 BI858056 AU133205 
    AI564242 AI049627 BU741998 BM787552 H88350 T57326 CA443803 AI738918 
    BQ222732 CR594833 CA443830 BQ440875 BI492278 BU189783 AA358282 AA350650 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ST13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGATCCAG
    ST13 Expression
    About this image


    ST13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Kidney (Urinary System)
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
    ST13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ST13 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including ST13: 
              Cellular Stress Responses in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ST13
    OriGene qSTAR qPCR primer pairs in human, mouse for ST13
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ST13
    QuantiTect SYBR Green Assays in human, mouse, rat ST13
    QuantiFast Probe-based Assays in human, mouse, rat ST13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ST13 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia St131 , 5 suppression of tumorigenicity 131, 5 89.22(n)1
    93.48(a)1
      15 (38.07 cM)5
    703561  NM_133726.21  NP_598487.11 
     813636695 
    chicken
    (Gallus gallus)
    Aves ST131 suppression of tumorigenicity 13 (colon carcinoma) more 79.57(n)
    83.9(a)
      418003  NM_001030757.1  NP_001025928.1 
    lizard
    (Anolis carolinensis)
    Reptilia ST136
    suppression of tumorigenicity 13 (colon carcinoma)...
    53(a)
    1 ↔ 1
    GL343345.1(212806-213594)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.48142 Xenopus laevis transcribed sequence with weak similarity more 77.57(n)    BQ723839.1 
    zebrafish
    (Danio rerio)
    Actinopterygii st132 suppression of tumorigenicity 13 (colon carcinoma) more 74.98(n)   327184  BC063322.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG29473
    HIP-R1
    chaperone3
    Hsc/Hsp70-interacting protein related1
    37(a)3
    49.79(n)1
    43.71(a)1
      3F13
    313351  NM_001014719.21  NP_001014719.21 
    worm
    (Caenorhabditis elegans)
    Secernentea hip-11 hip-1 51.69(n)
    48.02(a)
      176794  NM_067410.3  NP_499811.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HIP11 HIP1 58.42(n)
    52.3(a)
      828363  NM_118393.2  NP_567663.1 
    rice
    (Oryza sativa)
    Liliopsida AK102264.12   -- 74.8(n)    AK102264.1 


    ENSEMBL Gene Tree for ST13 (if available)
    TreeFam Gene Tree for ST13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ST13 gene
    2 SIMAP similar genes for ST13 using alignment to 7 protein entries:     F10A1_HUMAN (see all proteins):
    ST13P5    ST13P4

    Find genes that share paralogs with ST13           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for ST13 (see all 23)
    PGOHUM00000238909 PGOHUM00000242489 PGOHUM00000242862 PGOHUM00000239482 PGOHUM00000239567


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ST13 (see all 656)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2012236741,2
    --41220136(+) GGGGT-/GGGGGG 1 -- ds50010--------
    rs357018641,2
    C--41220350(+) CTCCT-/CACCACCT 1 -- cds10--------
    rs1502922111,2
    --41220441(+) GAAACC/TGTATT 1 -- ds50010--------
    rs1823168451,2
    --41220561(+) AATGTA/GTATTA 1 -- ds50010--------
    rs797634221,2
    F--41220588(+) AAAAGC/GACAGG 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs782657721,2
    C--41220684(+) ATAAGG/TAATCC 1 -- ut310--------
    rs57580981,2
    C,F,H--41220756(+) TACACA/GTTAAC 1 -- ut31 ese316Minor allele frequency- G:0.11NS EA NA WA 1230
    rs1877313421,2
    --41221135(+) GAATGC/TACAAC 1 -- ut310--------
    rs1448795391,2
    C--41221318(+) AAAAAA/GATCGG 1 -- ut310--------
    rs1490378121,2
    --41221669(+) GTCTTC/TAGCTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ST13 (41220539 - 41253026 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ST13:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4978n71CNV Loss21882294
    nsv915112CNV Loss21882294
    nsv834206CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606796    OMIM disorders: --


    Find genes that share disorders with ST13           About GenesLikeMe

    2 Novoseek inferred disease relationships for ST13 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 52.9 14 10330192 (1), 17323428 (1), 18052042 (1), 10567384 (1) (see all 10)
    tumors 3.42 1 9925927 (1)


    Export disorders for ST13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ST13 gene, integrated from 10 sources (see all 118):
    (articles sorted by number of sources associating them with ST13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein. (PubMed id 8721986)1, 2, 3, 9 Prapapanich V.... Smith D.F. (Mol. Endocrinol. 1996)
    2. Assignment1 of human putative tumor suppressor genes ST13 (alias SNC6) and ST14 (alias SNC19) to human chromosome bands 22q13 and 11q24--&gt;q25 by in situ hybridization. (PubMed id 9925927)1, 3, 9 Zhang Y....Zheng S. (Cytogenet. Cell Genet. 1998)
    3. G protein-coupled receptor kinase 5 phosphorylation of Hip regulates internalization of the chemokine receptor CXCR4. (PubMed id 21728385)1, 2 Barker B.L. and Benovic J.L. (Biochemistry 2011)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (Int. J. Cancer 1999)
    7. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    8. Characterization of colorectal-cancer-related cDNA clones obtained by subtractive hybridization screening. (PubMed id 9292708)1, 2 Cao J.... Zheng S. (J. Cancer Res. Clin. Oncol. 1997)
    9. Differential expression of HSU17714 gene in colorectal cancer and normal colonic mucosa. (PubMed id 9387309)1, 2 Mo Y.... Shen D. (Zhonghua Zhong Liu Za Zhi 1996)
    10. Proteolysis of HIP during apoptosis occurs within a region similar to the BID loop. (PubMed id 17013759)1, 9 Caruso J.A. and Reiners J.J. (Apoptosis 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6767 HGNC: 11343 AceView: ST13 Ensembl:ENSG00000100380 euGenes: HUgn6767
    ECgene: ST13 H-InvDB: ST13

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ST13 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ST13 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ST13 gene:
    Search GeneIP for patents involving ST13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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