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Aliases for ST13 Gene

Aliases for ST13 Gene

  • Suppression Of Tumorigenicity 13 (Colon Carcinoma) (Hsp70 Interacting Protein) 2 3
  • Progesterone Receptor-Associated P48 Protein 2 3 4
  • Suppression Of Tumorigenicity 13 Protein 3 4
  • Renal Carcinoma Antigen NY-REN-33 3 4
  • Putative Tumor Suppressor ST13 3 4
  • Aging-Associated Protein 2 3 4
  • FAM10A1 3 4
  • AAG2 3 4
  • SNC6 3 4
  • HIP 3 4
  • P48 3 6
  • HOP 3 6
  • Suppression Of Tumorigenicity 13 (Colon Carcinoma) (Hsp70-Interacting Protein) 2
  • Heat Shock 70kD Protein Binding Protein 3
  • Hsp70-Interacting Protein 3
  • Hsc70-Interacting Protein 3
  • Protein FAM10A1 4
  • FAM10A4 3
  • HSPABP1 3
  • PRO0786 3
  • HSPABP 3

External Ids for ST13 Gene

Previous GeneCards Identifiers for ST13 Gene

  • GC22M037835
  • GC22M039463
  • GC22M039545
  • GC22M041220

Summaries for ST13 Gene

Entrez Gene Summary for ST13 Gene

  • The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

GeneCards Summary for ST13 Gene

ST13 (Suppression Of Tumorigenicity 13 (Colon Carcinoma) (Hsp70 Interacting Protein)) is a Protein Coding gene. Among its related pathways are HOP Signaling and Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics. GO annotations related to this gene include identical protein binding and protein complex binding.

UniProtKB/Swiss-Prot for ST13 Gene

  • One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity).

Gene Wiki entry for ST13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST13 Gene

Genomics for ST13 Gene

Regulatory Elements for ST13 Gene

Genomic Location for ST13 Gene

Start:
40,824,535 bp from pter
End:
40,857,022 bp from pter
Size:
32,488 bases
Orientation:
Minus strand

Genomic View for ST13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ST13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST13 Gene

Proteins for ST13 Gene

  • Protein details for ST13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50502-F10A1_HUMAN
    Recommended name:
    Hsc70-interacting protein
    Protein Accession:
    P50502
    Secondary Accessions:
    • O14999
    • Q2TU77

    Protein attributes for ST13 Gene

    Size:
    369 amino acids
    Molecular mass:
    41332 Da
    Quaternary structure:
    • Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90 (By similarity). Interacts (via the C-terminus 303- 319 AA) with GRK5.

    Three dimensional structures from OCA and Proteopedia for ST13 Gene

neXtProt entry for ST13 Gene

Proteomics data for ST13 Gene at MOPED

Post-translational modifications for ST13 Gene

  • Ubiquitination at Lys17, Lys41, Lys142, Lys153, Lys160, Lys163, Lys186, Lys353, Lys360, and Lys364
  • Modification sites at PhosphoSitePlus

Other Protein References for ST13 Gene

No data available for DME Specific Peptides for ST13 Gene

Domains for ST13 Gene

Gene Families for ST13 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for ST13 Gene

Graphical View of Domain Structure for InterPro Entry

P50502

UniProtKB/Swiss-Prot:

F10A1_HUMAN :
  • P50502
Domain:
  • Contains 1 STI1 domain.
Family:
  • Belongs to the FAM10 family.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with ST13: view

Function for ST13 Gene

Molecular function for ST13 Gene

GENATLAS Biochemistry: suppression of tumorigenicity 13,colon carcinoma,see TSG22C
UniProtKB/Swiss-Prot Function: One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity).

Gene Ontology (GO) - Molecular Function for ST13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21163940
GO:0019904 protein domain specific binding IEA --
GO:0030544 Hsp70 protein binding IEA --
GO:0030674 protein binding, bridging TAS 8721986
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with ST13: view

Phenotypes for ST13 Gene

genes like me logo Genes that share phenotypes with ST13: view

Animal Model Products

CRISPR Products

miRNA for ST13 Gene

miRTarBase miRNAs that target ST13

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ST13

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ST13 Gene

Localization for ST13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST13 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ST13 Gene COMPARTMENTS Subcellular localization image for ST13 gene
Compartment Confidence
cytosol 4
nucleus 1

Gene Ontology (GO) - Cellular Components for ST13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IEA --
GO:0043234 protein complex IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ST13: view

Pathways for ST13 Gene

genes like me logo Genes that share pathways with ST13: view

Pathways by source for ST13 Gene

1 Qiagen pathway for ST13 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ST13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 8721986
GO:0051260 protein homooligomerization IEA --
GO:0061084 negative regulation of protein refolding IEA --
GO:0070389 chaperone cofactor-dependent protein refolding IEA --
genes like me logo Genes that share ontologies with ST13: view

Compounds for ST13 Gene

(5) Novoseek inferred chemical compound relationships for ST13 Gene

Compound -log(P) Hits PubMed IDs
steroid 52.7 9
progesterone 46.1 7
prostacyclin 43.5 6
atp 40.1 6
adp 5.42 2
genes like me logo Genes that share compounds with ST13: view

Transcripts for ST13 Gene

Unigene Clusters for ST13 Gene

Suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ST13

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST13 Gene

No ASD Table

Relevant External Links for ST13 Gene

GeneLoc Exon Structure for
ST13
ECgene alternative splicing isoforms for
ST13

Expression for ST13 Gene

mRNA expression in normal human tissues for ST13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ST13 Gene

SOURCE GeneReport for Unigene cluster for ST13 Gene Hs.712713

genes like me logo Genes that share expressions with ST13: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ST13 Gene

Orthologs for ST13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ST13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST13 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 79 (a)
OneToMany
ST13 35
  • 93.59 (n)
  • 95.12 (a)
ST13 36
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
ST13 36
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia St13 35
  • 89.22 (n)
  • 93.48 (a)
St13 16
St13 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ST13 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia St13 35
  • 89.67 (n)
  • 92.39 (a)
chicken
(Gallus gallus)
Aves ST13 35
  • 79.57 (n)
  • 83.9 (a)
ST13 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST13 36
  • 53 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4814 35
tropical clawed frog
(Silurana tropicalis)
Amphibia st13 35
  • 69.8 (n)
  • 75.97 (a)
zebrafish
(Danio rerio)
Actinopterygii st13 35
st13 35
  • 66.01 (n)
  • 69.66 (a)
st13 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009119 35
  • 52.07 (n)
  • 48.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta HIP 36
  • 38 (a)
OneToMany
HIP-R 35
  • 49.79 (n)
  • 43.71 (a)
HIP-R 36
  • 38 (a)
OneToMany
CG2947 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea hip-1 35
  • 51.69 (n)
  • 48.02 (a)
hip-1 36
  • 41 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons HIP1 35
  • 58.42 (n)
  • 52.3 (a)
corn
(Zea mays)
Liliopsida Zm.4878 35
rice
(Oryza sativa)
Liliopsida Os02g0100300 35
  • 55.2 (n)
  • 49.2 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.9783 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10176 36
  • 36 (a)
OneToOne
Species with no ortholog for ST13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ST13 Gene

ENSEMBL:
Gene Tree for ST13 (if available)
TreeFam:
Gene Tree for ST13 (if available)

Paralogs for ST13 Gene

Selected SIMAP similar genes for ST13 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ST13: view

No data available for Paralogs for ST13 Gene

Variants for ST13 Gene

Sequence variations from dbSNP and Humsavar for ST13 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs80685 -- 40,836,339(+) CCAGC(C/T)ACTTG intron-variant
rs138335 -- 40,831,082(+) TTGTA(C/G)AAAAA intron-variant
rs138336 -- 40,833,565(+) ATCTC(-/A)AAAAA intron-variant
rs138337 -- 40,835,049(+) GTTAA(A/G)TTCAC intron-variant
rs138338 -- 40,838,926(+) aaaaa(-/AA)ttCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ST13 Gene

Variant ID Type Subtype PubMed ID
nsv915112 CNV Loss 21882294
dgv4978n71 CNV Loss 21882294
nsv834206 CNV Gain 17160897

Relevant External Links for ST13 Gene

HapMap Linkage Disequilibrium report
ST13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST13 Gene

Disorders for ST13 Gene

(2) Novoseek inferred disease relationships for ST13 Gene

Disease -log(P) Hits PubMed IDs
shock 52.9 10
tumors 3.42 1
genes like me logo Genes that share disorders with ST13: view

No data available for UniProtKB/Swiss-Prot for ST13 Gene

Publications for ST13 Gene

  1. Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein. (PMID: 8721986) Prapapanich V. … Smith D.F. (Mol. Endocrinol. 1996) 2 3 4 23
  2. Assignment1 of human putative tumor suppressor genes ST13 (alias SNC6) and ST14 (alias SNC19) to human chromosome bands 22q13 and 11q24-->q25 by in situ hybridization. (PMID: 9925927) Zhang Y. … Zheng S. (Cytogenet. Cell Genet. 1998) 2 3 23
  3. The Hsp organizer protein hop enhances the rate of but is not essential for glucocorticoid receptor folding by the multiprotein Hsp90-based chaperone system. (PMID: 10702249) Morishima Y. … Pratt W.B. (J. Biol. Chem. 2000) 3 23
  4. Mutational analysis of the hsp70-interacting protein Hip. (PMID: 8887650) Prapapanich V. … Smith D.F. (Mol. Cell. Biol. 1996) 3 23
  5. Hsc/Hsp70 interacting protein (hip) associates with CXCR2 and regulates the receptor signaling and trafficking. (PMID: 11751889) Fan G.H. … Richmond A. (J. Biol. Chem. 2002) 3 23

Products for ST13 Gene

Sources for ST13 Gene

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