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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ST13 Gene

protein-coding   GIFtS: 60
GCID: GC22M041220

suppression of tumorigenicity 13 (colon carcinoma) (Hsp7...

(Previous name: suppression of tumorigenicity 13 (colon carcinoma) (Hsp7...)
 Explore 12 diseases affiliated with
ST13 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ST13    

Aliases
for ST13 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Suppression Of Tumorigenicity 13 (Colon Carcinoma) (Hsp70 Interacting
Protein)1 2
     AAG22 3
FAM10A11 2 3     HOP2 5
HIP1 2 3     Suppression Of Tumorigenicity 13 (Colon Carcinoma) (Hsp70-Interacting Protein)1
SNC61 2 3     FAM10A42
P481 2 5     HSPABP2
HSPABP11 2     PRO07862
Aging-Associated Protein 22 3     Heat Shock 70kD Protein Binding Protein2
Progesterone Receptor-Associated P48 Protein2 3     Hsc70-Interacting Protein2
Putative Tumor Suppressor ST132 3     Hsp70-Interacting Protein2
Renal Carcinoma Antigen NY-REN-332 3     Hip3
Suppression Of Tumorigenicity 13 Protein2 3     Protein FAM10A13

External Ids:    HGNC: 113431   Entrez Gene: 67672   Ensembl: ENSG000001003807   OMIM: 6067965   UniProtKB: P505023   

Export aliases for ST13 gene to outside databases

Previous GC identifers: GC22M037835 GC22M039463 GC22M039545


Summaries
for ST13 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ST13:
The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70
and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which
requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated
in colorectal carcinoma tissue suggesting that is a candidate tumor suppressor gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: F10A1_HUMAN, P50502
Function: One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the
HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its
own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity)

Gene Wiki entry for ST13


Genomic Views
for ST13 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ST13 gene promoter:
         Elk-1   POU3F2   HNF-1A   Evi-1   C/EBPalpha   AREB6   Pax-3   PPAR-gamma1   HNF-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ST13 promoter sequence
   Search SABiosciences Chromatin IP Primers for ST13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ST13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2

ST13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST13 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M041220:  view genomic region     (about GC identifiers)

Start:
 41,220,539 bp from pter      End:
 41,253,026 bp from pter
Size:
 32,488 bases      Orientation:
 minus strand

Proteins
for ST13 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: F10A1_HUMAN, P50502 (See protein sequence)
Recommended Name: Hsc70-interacting protein  
Size: 369 amino acids; 41332 Da
Subunit: Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90 (By similarity). Interacts (via the
C-terminus 303- 319 AA) with GRK5
Subcellular location: Cytoplasm (By similarity)
1 PDB 3D structure from and Proteopedia for ST13:
1UZS (3D)    
Secondary accessions: O14999 Q2TU77

Explore the universe of human proteins at neXtProt for ST13: NX_P50502

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P50502

    • ST13 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003923.2  
    ENSEMBL proteins: 
     ENSP00000216218   ENSP00000397062   ENSP00000412049   ENSP00000392067  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: ST13
    Browse OriGene Protein Over-expression Lysates
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    GenScript Custom Purified and Recombinant Proteins Services for ST13
    Novus Biologicals ST13 Proteins
    Novus Biologicals ST13 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for ST13
    Uscn Proteins for ST13

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS8721986
    GO:0005829cytosol IEA--
    GO:0043234protein complex IEA--


    ST13 for ontologies           About GeneDecksing



    ST13 Antibody Products: 
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    ThermoFisher Antibody for ST13

    Assay Products for ST13: 
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    Uscn ELISAs and CLIAs for ST13

    Protein Domains /
    Families
    for ST13 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ST13 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR006636 STI1_HS-bd
     IPR001440 TPR-1
     IPR011990 TPR-like_helical
     IPR013105 TPR_2
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry P50502

    ProtoNet protein and cluster: P50502

    1 Blocks protein family: IPB006636 Heat shock chaperonin-binding

    UniProtKB/Swiss-Prot: F10A1_HUMAN, P50502
    Similarity: Belongs to the FAM10 family
    Similarity: Contains 1 STI1 domain
    Similarity: Contains 3 TPR repeats


    Function
    for ST13 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: F10A1_HUMAN, P50502
    Function: One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the
    HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its
    own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity)

         Genatlas biochemistry entry for ST13:
    suppression of tumorigenicity 13,colon carcinoma,see TSG22C

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST13
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate ST13 (see all 29):
    hsa-miR-3149 hsa-miR-4291 hsa-miR-3200-5p hsa-miR-3607-3p hsa-miR-520d-5p hsa-miR-137 hsa-miR-509-5p hsa-miR-548s
    SwitchGear 3'UTR luciferase reporter plasmid: ST13 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ST13 (see all 7)
    OriGene shRNA RFP: ST13
    OriGene siRNA: ST13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST13

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ST13

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ST13 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ST13
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ST13 (NM_003932)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST13 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ST13
    Search LifeMap BioReagents cell lines for ST13

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST13

    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0019904protein domain specific binding IEA--
    GO:0030544Hsp70 protein binding IEA--
    GO:0030674protein binding, bridging TAS8721986
    GO:0032403protein complex binding IEA--


    ST13 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ST13:
     Decreased TP53 protein express 


    Pathways & Interactions
    for ST13 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics
    		Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics1.00


    1 PharmGKB Pathway for ST13
        Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ST13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/58 Interacting proteins for ST13 (P505021, 2, 3 ENSP000002162184) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD101Q930332, 3, ENSP000002566524MINT-65086 I2D: score=5 STRING: ENSP00000256652
    SMAD2Q157962, 3, ENSP000002621604MINT-61598 I2D: score=3 STRING: ENSP00000262160
    BAG1Q999332, 3MINT-45857 MINT-45858 I2D: score=1 
    OLFM2O958972, 3MINT-63324 I2D: score=5 
    MAP3K3Q997592, 3MINT-48449 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS8721986
    GO:0051260protein homooligomerization IEA--
    GO:0061084negative regulation of protein refolding IEA--
    GO:0070389chaperone cofactor-dependent protein refolding IEA--


    ST13 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ST13 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ST13 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ST13
    5 Novoseek chemical compound relationships for ST13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    steroid 52.7 14 10702249 (2), 17323428 (1), 8939864 (1), 12093808 (1) (see all 8)
    progesterone 46.1 8 8721986 (3), 10630990 (1), 10364185 (1), 14627198 (1) (see all 5)
    prostacyclin 43.5 6 17164137 (2), 20395296 (1), 11961139 (1), 17704830 (1) (see all 5)
    atp 40.1 9 10364185 (1), 11809754 (1), 12093808 (1), 12563018 (1) (see all 6)
    adp 5.42 2 9321400 (1), 7585962 (1)

    Search CenterWatch for drugs/clinical trials and news about ST13 / F10A1 

    Transcripts
    for ST13 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ST13 gene: 
    NM_003932.3  

    Unigene Cluster for ST13:

    Suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
    Hs.712713  [show with all ESTs]
    Unigene Representative Sequence: NM_003932
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216218(uc003aze.3 uc011aow.2) ENST00000480048 ENST00000455824
    ENST00000413424 ENST00000411695 ENST00000495652

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ST13
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ST13
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate ST13 (see all 29):
    hsa-miR-3149 hsa-miR-4291 hsa-miR-3200-5p hsa-miR-3607-3p hsa-miR-520d-5p hsa-miR-137 hsa-miR-509-5p hsa-miR-548s
    SwitchGear 3'UTR luciferase reporter plasmid: ST13 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ST13 (see all 7)
    OriGene shRNA RFP: ST13
    OriGene siRNA: ST13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ST13
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ST13 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ST13
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ST13 (NM_003932)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ST13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ST13 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ST13
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ST13
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ST13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ST13

    Additional cDNA sequence: 

    AF116650.1 AK130770.1 AK303530.1 AK312399.1 AK316155.1 AY513286.1 AY826824.1 AY826825.1 
    BC015317.1 BC052982.1 BC071629.1 BC101206.1 BC101207.2 BC101208.1 BC107148.1 BC121107.1 
    BC121108.1 BC139724.1 CR456586.1 U17714.1 U28918.1 

    24/55 DOTS entries (see all 55):

    DT.99998054  DT.100892017  DT.100000399  DT.456282  DT.92464568  DT.92464561  DT.95149390  DT.85101734 
    DT.120650009  DT.100892054  DT.120649901  DT.92343743  DT.92464548  DT.100892025  DT.100892033  DT.100034556 
    DT.100653922  DT.100686762  DT.100770617  DT.100892013  DT.100892026  DT.100892034  DT.92464564  DT.95149407 

    24/818 AceView cDNA sequences (see all 818):

    C00124 AA758434 BM787552 CR592764 AI049627 CD365025 CB410643 CR607174 
    CK819442 BM830523 BQ226056 CB216971 BQ423543 AA609725 CR612386 BQ214448 
    BM463465 NM_003932 BQ051171 CR623583 CR617748 BM725101 BQ440875 CF146871 

    GeneLoc Exon Structure


    Expression
    for ST13 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ST13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGGATCCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ST13 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Intermediate MesodermIntermediate MesodermIntermediate Mesoderm
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ST13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ST13

    SOURCE GeneReport for Unigene cluster: Hs.712713
        SABiosciences Expression via Pathway-Focused PCR Array including ST13: 
              Cellular Stress Responses in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ST13

    Orthologs
    for ST13 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ST13 gene from 9/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia St131 , 5 suppression of tumorigenicity 131, 5 90.49(n)1
    94.57(a)1    		   15 (38.07 cM)5
    703561  NM_133726.21  NP_598487.11 
     813636695 
    chicken
    (Gallus gallus)    		 Aves ST131 suppression of tumorigenicity 13 (colon carcinoma) more 80.06(n)
    84.27(a)    		   418003  NM_001030757.1  NP_001025928.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    ST136
    		 --
    		 80(a)
    52(a)
    		 1 ↔ 1
    possible ortholog
    		 5(25992119-26014076)
    GL343345.1(212806-213594)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.48142 Xenopus laevis transcribed sequence with weak similarity more 77.57(n)    BQ723839.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii st132 suppression of tumorigenicity 13 (colon carcinoma) more 74.98(n)   327184  BC063322.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG29473
    HIP-R1    		 chaperone3
    Hsc/Hsp70-interacting protein related1    		 37(a)3
    52.94(n)1
    47.8(a)1    		   3F13
    313351  NM_166988.41  NP_726885.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea hip-11 Protein HIP-1 52.86(n)
    50.42(a)    		   176794  NM_067410.2  NP_499811.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons HIP11 HSP70-interacting protein 1 58.97(n)
    51.65(a)    		   828363  NM_118393.2  NP_567663.1 
    rice
    (Oryza sativa)    		 Liliopsida AK102264.12   -- 74.8(n)    AK102264.1 


    ENSEMBL Gene Tree for ST13 (if available)
    TreeFam Gene Tree for ST13 (if available) 

    Paralogs
    for ST13 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ST13 gene
    2 SIMAP similar genes for ST13 using alignment to 7 protein entries:     F10A1_HUMAN (see all proteins):
    ST13P5    ST13P4

    ST13 for paralogs           About GeneDecksing


    5/23 Pseudogenes.org Pseudogenes for ST13 (see all 23)
    PGOHUM00000238909 PGOHUM00000242489 PGOHUM00000242862 PGOHUM00000239482 PGOHUM00000239567


    Genomic Variants
    for ST13 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/584 NCBI SNPs in ST13 are shown (see all 584)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs734127471,2
    		C,--24214048(+) GTGTTA/GTATTA 2 -- us2k12Minor allele frequency- G:0.06WA 120
    rs283645921,2
    		--24214633(-) CAGCGC/GCTGGG 2 -- us2k10--------
    rs1112402131,2
    		C--24214674(+) TGCCGA/C/GAAGAC 2 -- us2k11CSA 1
    rs1137730061,2
    		--24215053(+) CAGCTC/TGGGGC 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs738857061,2
    		C,--24215400(+) CCAACC/TCTCTG 2 -- int12Minor allele frequency- T:0.04WA 120
    rs775128801,2
    		F,--24216331(+) GTAGAA/GACCAG 2 -- int11Minor allele frequency- G:0.17WA 118
    rs2012236741,2
    		--41220136(+) GGGGT-/GGGGGG 1 -- ds50010--------
    rs357018641,2
    		C,--41220350(+) CTCCT-/CACCACCT 1 -- ds50010--------
    rs1502922111,2
    		--41220441(+) GAAACC/TGTATT 1 -- ds50010--------
    rs1823168451,2
    		--41220561(+) AATGTA/GTATTA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ST13 (41220539 - 41253026 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ST13
         1 CNV: 91067

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    Disorders / Diseases
    for ST13 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ST13 for disorders           About GeneDecksing

    OMIM gene information: 606796    OMIM disorders: --

    12 diseases for ST13:    About MalaCards
    carcinoma    colon carcinoma    renal carcinoma    yellow fever
    renal cell carcinoma    cystic fibrosis    parkinson's disease    fibrosis
    colorectal cancer    malaria    pancreatic cancer    pancreatitis

    2 Novoseek disease relationships for ST13 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 52.9 14 10330192 (1), 17323428 (1), 18052042 (1), 10567384 (1) (see all 10)
    tumors 3.42 1 9925927 (1)


    Export disorders for ST13 gene to outside databases

    Publications
    for ST13 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ST13 gene, integrated from 9 sources (see all 107):
    (articles sorted by number of sources associating them with ST13)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein. (PubMed id 8721986)1, 2, 3, 9 Prapapanich V.... Smith D.F. (1996)
    2. Assignment1 of human putative tumor suppressor genes ST13 (alias SNC6) and ST14 (alias SNC19) to human chromosome bands 22q13 and 11q24-->q25 by in situ hybridization. (PubMed id 9925927)1, 3, 9 Zhang Y....Zheng S. (1998)
    3. G protein-coupled receptor kinase 5 phosphorylation of Hip regulates internalization of the chemokine receptor CXCR4. (PubMed id 21728385)1, 2 Barker B.L. and Benovic J.L. (2011)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (1999)
    7. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    8. Characterization of colorectal-cancer-related cDNA clones obtained by subtractive hybridization screening. (PubMed id 9292708)1, 2 Cao J.... Zheng S. (1997)
    9. Differential expression of HSU17714 gene in colorectal cancer and normal colonic mucosa. (PubMed id 9387309)1, 2 Mo Y.... Shen D. (1996)
    10. Proteolysis of HIP during apoptosis occurs within a region similar to the BID loop. (PubMed id 17013759)1, 9 Caruso J.A. and Reiners J.J. (2006)

    External Searches for ST13 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ST13 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6767 HGNC: 11343 AceView: ST13 Ensembl:ENSG00000100380 euGenes: HUgn6767
    ECgene: ST13 H-InvDB: ST13

    Other Databases showing ST13 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ST13 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ST13 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ST13 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ST13 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ST13 gene:
    Search GeneIP for patents involving ST13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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