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Aliases for ST13 Gene

Aliases for ST13 Gene

  • ST13, Hsp70 Interacting Protein 2 3 5
  • Progesterone Receptor-Associated P48 Protein 2 3 4
  • Suppression Of Tumorigenicity 13 (Colon Carcinoma) (Hsp70 Interacting Protein) 2 3
  • Suppression Of Tumorigenicity 13 Protein 3 4
  • Renal Carcinoma Antigen NY-REN-33 3 4
  • Putative Tumor Suppressor ST13 3 4
  • Aging-Associated Protein 2 3 4
  • FAM10A1 3 4
  • AAG2 3 4
  • SNC6 3 4
  • HIP 3 4
  • Testis Secretory Sperm-Binding Protein Li 233m 3
  • Heat Shock 70kD Protein Binding Protein 3
  • Hsp70-Interacting Protein 3
  • Hsc70-Interacting Protein 3
  • Protein FAM10A1 4
  • FAM10A4 3
  • HSPABP1 3
  • PRO0786 3
  • HSPABP 3
  • P48 3
  • HOP 3

External Ids for ST13 Gene

Previous GeneCards Identifiers for ST13 Gene

  • GC22M037835
  • GC22M039463
  • GC22M039545
  • GC22M041220
  • GC22M040825
  • GC22M040957
  • GC22M040960
  • GC22M041090

Summaries for ST13 Gene

Entrez Gene Summary for ST13 Gene

  • The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

GeneCards Summary for ST13 Gene

ST13 (ST13, Hsp70 Interacting Protein) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME) and Cellular response to heat stress. GO annotations related to this gene include identical protein binding and protein complex binding.

UniProtKB/Swiss-Prot for ST13 Gene

  • One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity).

Gene Wiki entry for ST13 Gene

Additional gene information for ST13 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST13 Gene

Genomics for ST13 Gene

Regulatory Elements for ST13 Gene

Enhancers for ST13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H040650 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10 +203.7 203690 4 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 FOS SP3 XPNPEP3 GAPDHP37 MCHR1 L3MBTL2 LOC101927257 SLC25A17 ZC3H7B ST13 PMM1 ADSL
GH22H040644 1.5 Ensembl ENCODE dbSUPER 10 +211.5 211484 2 PKNOX1 FOXA2 MLX ARID4B SLC30A9 ZNF143 SP5 ZC3H11A REST KAT8 XPNPEP3 GAPDHP37 MCHR1 LOC101927257 ST13 ADSL LOC105373038 MKL1
GH22H040682 1.5 FANTOM5 Ensembl ENCODE 9.9 +172.8 172789 3 RB1 TBL1XR1 SIN3A BATF RAD21 EGR1 ZNF366 ZNF143 ZNF207 FOS XPNPEP3 LOC101927257 ST13 MCHR1 GC22M041755 LOC100313968
GH22H040950 1.4 FANTOM5 ENCODE 10.4 -94.5 -94545 3 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 EP300 XRCC6 EP300-AS1 ADSL DNAJB7 ST13 XPNPEP3 RBX1 GC22P040976
GH22H040720 1.4 Ensembl ENCODE dbSUPER 10.2 +135.7 135679 1 ELF3 PKNOX1 INSM2 KLF17 FEZF1 ZNF366 ZSCAN5C ZNF391 EGR2 ZNF362 XPNPEP3 LOC101927257 ST13 GC22M041755 LOC100313968
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ST13 on UCSC Golden Path with GeneCards custom track

Promoters for ST13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000301960 222 2401 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 SP3

Genomic Location for ST13 Gene

Chromosome:
22
Start:
40,824,535 bp from pter
End:
40,857,022 bp from pter
Size:
32,488 bases
Orientation:
Minus strand

Genomic View for ST13 Gene

Genes around ST13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST13 Gene

Proteins for ST13 Gene

  • Protein details for ST13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50502-F10A1_HUMAN
    Recommended name:
    Hsc70-interacting protein
    Protein Accession:
    P50502
    Secondary Accessions:
    • O14999
    • Q2TU77

    Protein attributes for ST13 Gene

    Size:
    369 amino acids
    Molecular mass:
    41332 Da
    Quaternary structure:
    • Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90 (By similarity). Interacts (via the C-terminus 303- 319 AA) with GRK5.

    Three dimensional structures from OCA and Proteopedia for ST13 Gene

neXtProt entry for ST13 Gene

Post-translational modifications for ST13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ST13 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ST13 (HIP)
  • Santa Cruz Biotechnology (SCBT) Antibodies for ST13

No data available for DME Specific Peptides for ST13 Gene

Domains & Families for ST13 Gene

Gene Families for ST13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

P50502

UniProtKB/Swiss-Prot:

F10A1_HUMAN :
  • Belongs to the FAM10 family.
Family:
  • Belongs to the FAM10 family.
genes like me logo Genes that share domains with ST13: view

Function for ST13 Gene

Molecular function for ST13 Gene

GENATLAS Biochemistry:
suppression of tumorigenicity 13,colon carcinoma,see TSG22C
UniProtKB/Swiss-Prot Function:
One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity).

Phenotypes From GWAS Catalog for ST13 Gene

Gene Ontology (GO) - Molecular Function for ST13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11741305
GO:0019904 protein domain specific binding IEA --
GO:0030544 Hsp70 protein binding IEA --
GO:0030674 protein binding, bridging TAS 8721986
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with ST13: view
genes like me logo Genes that share phenotypes with ST13: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ST13
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ST13 Gene

Localization for ST13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST13 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST13 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ST13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8721986
GO:0005829 cytosol IDA --
GO:0043234 protein complex IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ST13: view

Pathways & Interactions for ST13 Gene

genes like me logo Genes that share pathways with ST13: view

Gene Ontology (GO) - Biological Process for ST13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 8721986
GO:0051260 protein homooligomerization IEA --
GO:0061084 negative regulation of protein refolding IEA --
GO:0070389 chaperone cofactor-dependent protein refolding IEA --
genes like me logo Genes that share ontologies with ST13: view

No data available for SIGNOR curated interactions for ST13 Gene

Drugs & Compounds for ST13 Gene

(3) Drugs for ST13 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
corticosteroids Pharma 0

(3) Additional Compounds for ST13 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ST13: view

Transcripts for ST13 Gene

Unigene Clusters for ST13 Gene

Suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ST13
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ST13 Gene

No ASD Table

Relevant External Links for ST13 Gene

GeneLoc Exon Structure for
ST13
ECgene alternative splicing isoforms for
ST13

Expression for ST13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ST13 Gene

This gene is overexpressed in Bone (30.1) and Nasal epithelium (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ST13 Gene



Protein tissue co-expression partners for ST13 Gene

NURSA nuclear receptor signaling pathways regulating expression of ST13 Gene:

ST13

SOURCE GeneReport for Unigene cluster for ST13 Gene:

Hs.712713

Evidence on tissue expression from TISSUES for ST13 Gene

  • Nervous system(4.8)
  • Skin(4.6)
  • Liver(4.5)
  • Intestine(4.4)
  • Muscle(2.6)
  • Kidney(2.4)
  • Heart(2.3)
  • Stomach(2.2)
  • Eye(2)
  • Lung(2)
genes like me logo Genes that share expression patterns with ST13: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST13 Gene

Orthologs for ST13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ST13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST13 33
  • 100 (n)
cow
(Bos Taurus)
Mammalia ST13 33 34
  • 93.59 (n)
-- 34
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia St13 33
  • 89.67 (n)
mouse
(Mus musculus)
Mammalia St13 33 16 34
  • 89.22 (n)
dog
(Canis familiaris)
Mammalia ST13 34
  • 89 (a)
OneToMany
-- 34
  • 81 (a)
OneToMany
-- 34
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ST13 34
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 62 (a)
OneToMany
-- 34
  • 56 (a)
OneToMany
chicken
(Gallus gallus)
Aves ST13 34 33
  • 79.57 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST13 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st13 33
  • 69.8 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4814 33
zebrafish
(Danio rerio)
Actinopterygii st13 33 33 34
  • 66.01 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009119 33
  • 52.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta HIP-R 33 34
  • 49.79 (n)
HIP 34
  • 38 (a)
OneToMany
CG2947 35
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea hip-1 33 34
  • 51.69 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons HIP1 33
  • 58.42 (n)
rice
(Oryza sativa)
Liliopsida Os02g0100300 33
  • 55.2 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.9783 33
corn
(Zea mays)
Liliopsida Zm.4878 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10176 34
  • 36 (a)
OneToOne
Species where no ortholog for ST13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ST13 Gene

ENSEMBL:
Gene Tree for ST13 (if available)
TreeFam:
Gene Tree for ST13 (if available)

Paralogs for ST13 Gene

No data available for Paralogs for ST13 Gene

Variants for ST13 Gene

Sequence variations from dbSNP and Humsavar for ST13 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs139991468 Uncertain significance 40,857,244(+) CTCTC(A/G)GGTTA upstream-variant-2KB, reference, synonymous-codon
rs149610579 Uncertain significance 40,857,159(+) CTCTT(C/T)CCGAC upstream-variant-2KB, utr-variant-5-prime
rs372922784 Uncertain significance 40,857,141(+) CCCGT(A/C/G/T)GTTAC upstream-variant-2KB, utr-variant-5-prime
rs374129317 Uncertain significance 40,857,138(+) TTCCC(A/C/T)GTCGT upstream-variant-2KB, utr-variant-5-prime
rs886057506 Uncertain significance 40,857,095(+) GCTGG(C/T)CCGGT upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ST13 Gene

Variant ID Type Subtype PubMed ID
nsv834206 CNV gain 17160897
nsv964634 CNV duplication 23825009
nsv979679 CNV duplication 23825009
nsv979680 CNV duplication 23825009

Variation tolerance for ST13 Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.68; 57.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ST13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST13 Gene

Disorders for ST13 Gene

Relevant External Links for ST13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ST13

No disorders were found for ST13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST13 Gene

Publications for ST13 Gene

  1. Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein. (PMID: 8721986) Prapapanich V … Smith DF (Molecular endocrinology (Baltimore, Md.) 1996) 2 3 4 22 60
  2. Assignment1 of human putative tumor suppressor genes ST13 (alias SNC6) and ST14 (alias SNC19) to human chromosome bands 22q13 and 11q24-->q25 by in situ hybridization. (PMID: 9925927) Zhang Y … Zheng S (Cytogenetics and cell genetics 1998) 2 3 22 60
  3. G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4. (PMID: 21728385) Barker BL … Benovic JL (Biochemistry 2011) 3 4 60
  4. Functional similarity between the chloroplast translocon component, Tic40, and the human co-chaperone, Hsp70-interacting protein (Hip). (PMID: 17535810) Bédard J … Jarvis P (The Journal of biological chemistry 2007) 3 22 60
  5. Proteolysis of HIP during apoptosis occurs within a region similar to the BID loop. (PMID: 17013759) Caruso JA … Reiners JJ (Apoptosis : an international journal on programmed cell death 2006) 3 22 60

Products for ST13 Gene

Sources for ST13 Gene

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