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SS18 Gene

protein-coding GIFtS: 59

GC18M021850

synovial sarcoma translocation, chromosome 18
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SSXT)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC116875 ^²
SSXT ^², ³, ⁵
SYT ^¹, ², ³, ⁵
SYT-SSX1 ^²
SYT-SSX2 ^²

Descriptions
Protein SYT ^³
SSXT/SSX4v fusion ^²
SYT/SSX4v fusion protein ^²
Synovial sarcoma, translocated to X chromosome ^², ³
synovial sarcoma translocation, chromosome 18 ^²

External Ids
HGNC: 11340¹
Entrez Gene: 6760²
UniProtKB: Q15532³
Ensembl: ENSG00000141380⁷

Search outside databases for aliases for SS18 gene

Previous GC identifers: GC18M023570 GC18M023308 GC18M021848

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for SS18

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SS18 gene

Entrez Gene cytogenetic band: 18q11.2 Ensembl cytogenetic band: 18q11.2 HGNC cytogenetic band: 18q11.2

SS18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M021850: (about GC identifiers)

Start:	21,850,215 bp from pter
End:	21,924,609 bp from pter
Size:	74,395 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000018.8 NT_010966.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SSXT_HUMAN, Q15532 (See protein sequence)

Recommended Name: Protein SSXT

Size: 418 amino acids; 45929 Da

Secondary accessions: Q16404 Q4VAX1 Q9BXC6

Alternative splicing: 2 isoforms: Q15532-1 Q15532-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001007560.1 NP_005628.2

ENSEMBL proteins:

ENSP00000269138 ENSP00000269137

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SS18, SS18-SSX1 Fusion Protein)
	Human Recombinant Proteins from Abnova (SS18)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	10072425

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Antibodies for SS18:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (SS18, SS18-SSX1 Fusion Protein), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SS18)
	Novus Biologicals Antibodies for SS18

Assays for SS18:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q15532

ProtoNet protein and cluster: Q15532

1 Blocks protein family: IPB007726 SSXT

UniProtKB/Swiss-Prot: SSXT_HUMAN, Q15532

Similarity: Belongs to the SS18 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SS18)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005637

Applied Biosystems Silencer® siRNAs for SS18

Sigma-Aldrich siRNA and siRNA Panels for SS18

Sigma-Aldrich shRNA for SS18

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SS18
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001007559
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001007559
untagged cDNA clones in CMV expression vector (see all 5): AK092611

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001007559

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ss18):

	embryogenesis	growth/size	homeostasis/metabolism	lethality-postnatal
lethality-prenatal/perinatal	nervous system

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for SS18

5/10 Interacting proteins for SS18 (ENSP00000269138³) via UniProtKB, MINT, and/or STRING (see all 10 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MLLT10	ENSP00000307411³	STRING (score=.973)
SMARCA2	ENSP00000265773³	STRING (score=.969)
SSX1	ENSP00000366118³	STRING (score=.965)
SMARCA4	ENSP00000350720³	STRING (score=.837)
EP300	ENSP00000263253³	STRING (score=.789)

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SS18
2 Novoseek chemical compound relationships for SS18 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
proline	25.56	3	10072425 (1), 7951320 (1), 16227627 (1)
tyrosine	0.00	2	10072425 (1), 16227627 (1)

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2 PharmGKB drug compound relationships for SS18 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
mercaptopurine	PD FA GN	12704389
methotrexate	PD FA GN	12704389

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SS18)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005637

Sigma-Aldrich siRNA and siRNA Panels for SS18

Sigma-Aldrich shRNA for SS18

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001007559 NM_005637

REFSEQ mRNAs for SS18 gene (2 alternative transcripts):

NM_001007559.1 NM_005637.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001007559 NM_005637

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001007559
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001007559
                                 untagged cDNA clones in CMV expression vector (see all 5): AK092611

Additional cDNA sequence:

AB300354.1 AB300355.1 AB300356.1 AB300357.1 AF244972.1 AF257501.1 AF343880.1 AF402618.1

AK289510.1 AK296949.1 AK299082.1 AK301504.1 AK304305.1 AK307923.1 AK316302.1 AK316338.1

BC096221.1 BC096222.1 BC096223.1 BC096224.1 CR542088.1 CR542103.1 X79201.1

20 DOTS entries:

DT.113857 DT.121097311 DT.100745105 DT.105718 DT.100798265 DT.121097290 DT.121097277 DT.75145663

DT.95276193 DT.100714045 DT.100798264 DT.101962724 DT.121097281 DT.121097284 DT.121097299 DT.121097302

DT.75107159 DT.97843921 DT.100798261 DT.91657720

24/248 AceView cDNA sequences (see all 248 ):

AA723137 CF529036 BE301610 BU521546 CB148207 CD364665 AW440568 CB068575

N59206 BM992802 BP370482 BF330745 BQ212753 AA376490 CA442904 BP360387

BE677244 BX486685 AW078821 BU687887 CK823193 AI458444 BX327397 BM472976

highest scoring ESTs for SS18:

X79201 AF244972 AF343880 AL134212 AL710073 AL710674 AU279615 AW367441 AW501965 AW504370

Unigene Cluster for SS18:

Synovial sarcoma translocation, chromosome 18

Hs.404263 [show with all ESTs]

Unigene Representative Sequence: NM_001007559

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for SS18 (see all 14 )

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	·	2d	·	2e	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11a	·	11b	·	11c	·	11d	·	11e	^	12a	·	12b	^
SP1:															-		-		-				-		-		-				-		-
SP2:															-		-		-				-		-		-				-		-
SP3:															-		-		-				-		-		-						-
SP4:															-		-		-				-				-				-		-
SP5:															-		-		-						-		-				-		-

ExUns:	13	^	14	^	15a	·	15b	^	16a	·	16b	^	17
SP1:					-
SP2:			-		-
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for SS18

2 Ensembl transcripts including schematic representations:

ENST00000269138 ENST00000269137

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SS18 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SS18

¹ / ² / ³

11 probe-sets matching SS18 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31872_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.87	X79201	1.00	1.00	1.00	1
59084_at²^{, 3}	U95-B	1	1.00	1.00	0.93	1.36	AA126814	0.40	1.00	0.76	1
34069_s_at²^{, 3}	U95-A	2	1.00	0.50	0.77	0.77	S79325	0.20	0.12	0.17	3
202817_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005637	0.60	1.00	0.82	1
202816_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW292882	0.60	1.00	0.82	1
209954_x_at²^{, 3}	U133-A	2	1.00	0.73	--	--	AF343880	0.80	1.00	0.91	1
216684_s_at²^{, 3}	U133-A	2	1.00	0.73	--	--	AF257501	0.40	1.00	0.76	1
202817_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202816_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209954_x_at²	U133Plus2	2	1.00	0.73	--	--	--	--	--	--	--
216684_s_at²	U133Plus2	2	1.00	0.73	--	--	--	--	--	--	--

GeneDecks SS18 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GACAGCCTTA

SOURCE GeneReport for Unigene cluster: Hs.404263
Expression variation in blood from EXPOLDB for SS18
UniProtKB/Swiss-Prot: SSXT_HUMAN, Q15532
Tissue specificity: Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other
human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SS18 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	SS18¹	--	synovial sarcoma translocation, chromosome 18	99.92(n) 99.76(a)	455345 XM_512069.2 XP_512069.2
cow (Bos taurus)	SS18¹	--	synovial sarcoma translocation, chromosome 18	93.76(n) 97.12(a)	540947 XM_613810.3 XP_613810.3
rat (Rattus norvegicus)	Ss18¹	--	synovial sarcoma translocation, Chromosome 18	90.75(n) 94.98(a)	361295 XM_341580.3 XP_341581.3
mouse (Mus musculus)	Ss18^{1, 5}	18⁵	synovial sarcoma translocation, Chromosome 18^{1, 5}	91.79(n)¹ 95.93(a)¹	268996¹ NM_009280.1¹ NP_033306.1¹ AI528781⁵ AK051601⁵ (see all 29)
chicken (Gallus gallus)	SS18¹	--	synovial sarcoma translocation, chromosome 18	89.31(n) 98.09(a)	421085 XM_419169.2 XP_419169.2

About this table Species with no ortholog for SS18

ENSEMBL Gene Tree for SS18

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SS18 gene

SS18L1² SS18L2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/411 NCBI SNPs in SS18 are shown (see all 411 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 131)

AB	SNP ID	Valid	Chr 18 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs15101^1,2	A,C,F,H,O	21851809(+)	`CCATGC/TTCCAG`	2	--	ut3¹ ese³		14	MN EU EA WA NA NS	2678
	rs607404^1,2	A,C,F,H,O	21852158(+)	`ACTAAA/TCCACA`	2	--	ut3¹		17	EA NA NS MN EU WA	928
	rs7239196^1,2	A,C,F,H	21926360(+)	`ATGCTG/CCTACT`	2	--	ng3¹		16	EU EA WA NA	1474
	rs994729^1,2	A,C,F,H	21925185(+)	`ACAAGG/ATGAAC`	2	--	ng3¹		3	MN EU NS	344
	rs4800708^1,2	A,C,F,H	21849983(+)	`AGCCTT/CATGGA`	2	--	ng5¹		12	EU EA WA NA NS	1018
	rs16942076^1,2	F,H	21852124(+)	`CAAGAG/ATATTT`	2	--	ut3¹		7	NA EU EA WA	562
	rs3813448^1,2	C,F	21924651(+)	`GCTCCG/AGGGCC`	2	--	ng3¹		1	EA	1288
--	rs7239135^1,2	C,F	21850619(+)	`ggcggA/Gggttg`	2	--	ut3¹ ese³		1	NS	34
	rs522706^1,2	C,H	21873391(-)	`TCCTTC/TTCAGC`	2	S/F	mis¹ ese³ trp³		8	EA NA MN EU WA	654
--	rs45443793^1,2	F	21925240(+)	`ACCTCC/GGAGTC`	2	--	ng3¹		1	NS	40

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HapMap Linkage Disequilibrium images for SS18 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600192

UniProtKB/Swiss-Prot: SSXT_HUMAN, Q15532

A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation

t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial

sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming

activity. Heterogeneity in the position of the breakpoint can occur (low frequency)

5 Novoseek disease relationships for SS18 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sarcoma synovial	96.12	53	17334346 (4), 7951320 (4), 10072425 (2), 15147271 (2) (see all 39)
sarcoma	64.96	6	17334346 (2), 15905690 (2), 12469233 (1)
ewings sarcoma	43.47	1	17334346 (1)
tumors	39.52	14	17334346 (3), 15905690 (2), 11668506 (1), 16682293 (1) (see all 9)
primary tumor	2.94	1	17175375 (1)

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1 PharmGKB disease relationship for SS18 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	PD FA GN	12704389

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/78 PubMed articles for SS18 gene (see all 78 ):

Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. (PubMed id 7951320)^{1, 2, 3, 4} Clark J....Cooper C.S. (1994)
Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression. (PubMed id 11368913)^{1, 3, 4} Brodin B.... Larsson O. (2001)
Common origin of the human synovial sarcoma associated SS18 and SS18L1 gene loci. (PubMed id 16484776)^{1, 2, 3} de Bruijn D.R. and Geurts van Kessel A. (2006)
Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript. (PubMed id 7495284)^{1, 3, 4} Fligman I....Ladanyi M. (1995)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The t(X;18)(p11.2;q11.2) translocation found in human synovial sarcomas involves two distinct loci on the X chromosome. (PubMed id 8152806)^{2, 3} Shipley J.M....Gusterson B.A. (1994)
The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10. (PubMed id 11423977)^{1, 3} de Bruijn D.R....Geurts van Kessel A. (2001)
Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus. (PubMed id 10072425)^{1, 3} Thaete C....Goodwin G. (1999)
Identification of a novel spliced variant of the SYT gene expressed in normal tissues and in synovial sarcoma. (PubMed id 11308259)^{1, 3} Tamborini E....Pilotti S. (2001)
The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins. (PubMed id 16227627)^{1, 3} Perani M....Goodwin G.H. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6760	HGNC: 11340	AceView: SS18	Ensembl:ENSG00000141380	euGenes: HUgn6760
ECgene: SS18	H-InvDB: SS18

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for SS18	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for SS18
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for SS18:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SS18-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SS18		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SS18		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SS18)
	Antibodies (SS18)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (SS18, SS18-SSX1 Fusion Protein)
	Antibodies (SS18, SS18-SSX1 Fusion Protein)

Search OriGene for SS18

Search Tocris compounds for SS18

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for SS18

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SS18 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for SS18

Summaries
for SS18

Genomic Location
for SS18

Proteins
for SS18

Protein Domains/
Families
for SS18

Gene Function
for SS18

Pathways & Interactions
for SS18

Drugs & Compounds
for SS18

Transcripts
for SS18

Expression
for SS18

Orthologs
for SS18

Paralogs
for SS18

SNPs/Variants
for SS18

Disorders & Mutations
for SS18

Medical News
for SS18

Publications
for SS18

Search for SS18

Genome Databases showing SS18

Other Databases showing SS18

Specialized Databases showing SS18

Licensable Technologies
for SS18

Services
for SS18

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SS18 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor SS18

Summariesfor SS18

Genomic Locationfor SS18

Proteinsfor SS18

Protein Domains/Familiesfor SS18

Gene Functionfor SS18

Pathways & Interactionsfor SS18

Drugs & Compoundsfor SS18

Transcriptsfor SS18

Expression for SS18

Orthologsfor SS18

Paralogsfor SS18

SNPs/Variantsfor SS18

Disorders & Mutationsfor SS18

Medical Newsfor SS18

Publicationsfor SS18

Search for SS18

Genome Databases showing SS18

Other Databases showing SS18

Specialized Databases showing SS18

Licensable Technologiesfor SS18

Servicesfor SS18

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SS18

Summaries
for SS18

Genomic Location
for SS18

Proteins
for SS18

Protein Domains/
Families
for SS18

Gene Function
for SS18

Pathways & Interactions
for SS18

Drugs & Compounds
for SS18

Transcripts
for SS18

Expression
for SS18

Orthologs
for SS18

Paralogs
for SS18

SNPs/Variants
for SS18

Disorders & Mutations
for SS18

Medical News
for SS18

Publications
for SS18

Licensable Technologies
for SS18

Services
for SS18