SSX9 Gene
protein-coding GIFtS: 34
GCID: GC0XM048154
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synovial sarcoma, X breakpoint 9
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Aliases
for SSX9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Synovial Sarcoma, X Breakpoint 91 2 |
Export aliases for SSX9 gene to outside databasesPrevious GC identifers: GC0XU900003 GC0XM046981 GC0XM047201 GC0XM047202 GC0XM047911 GC0XM048039 |
Summaries
for SSX9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SSX9:
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. Theseproteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral andcellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-basedimmunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found inall synovial sarcomas. This gene appears not to be involved in this type of chromosome translocation. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SSX9_HUMAN, Q7RTT3Function: Could act as a modulator of transcription
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Genomic Views
for SSX9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SSX9 gene promoter:
HOXA9B ATF-2 CUTL1 HNF-1A C/EBPalpha HNF-4alpha1 COMP1 HNF-1 Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SSX9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSX9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23SSX9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM048154: view genomic region
(about GC identifiers)
Start:
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48,154,885 bp from pter |
End:
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48,165,732 bp from pter |
Size:
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10,848 bases |
Orientation:
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minus strand |
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Proteins
for SSX9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SSX9_HUMAN, Q7RTT3 (See
protein sequence)Recommended Name: Protein SSX9 Size: 188 amino acids; 21553 DaExplore the universe of human proteins at neXtProt for SSX9: NX_Q7RTT3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7RTT3
SSX9 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000366107 ENSP00000385293
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005634 | nucleus |
IEA | -- |
SSX9 for ontologies About GeneDecksing
SSX9 Antibody Products:
Assay Products for SSX9: |
Protein
Domains /
Families
for SSX9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SSX9 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7RTT3ProtoNet protein and cluster: Q7RTT3 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: SSX9_HUMAN, Q7RTT3Similarity: Belongs to the SSX familySimilarity: Contains 1 KRAB-related domain |
Function
for SSX9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: SSX9_HUMAN, Q7RTT3Function: Could act as a modulator of transcription
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- |
SSX9 for ontologies About GeneDecksing
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Pathways & Interactions
for SSX9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SSX9
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
SSX9 for ontologies About GeneDecksing
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Drugs & Compounds
for SSX9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SSX9
Search CenterWatch for drugs/clinical trials and news about SSX9 
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Transcripts
for SSX9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SSX9 gene: NM_174962.3 2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000376909 ENST00000407081(uc022bvu.1)
2 AceView cDNA sequences: BK000689 NM_174962
GeneLoc Exon Structure
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Expression
for SSX9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SSX9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SSX9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SSX9
UniProtKB/Swiss-Prot: SSX9_HUMAN, Q7RTT3Tissue specificity: Not detected in any normal or tumor tissues
SABiosciences Custom PCR Arrays for SSX9
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SSX9
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SSX9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSX9 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSX9 |
Orthologs
for SSX9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for SSX9 (if available)
TreeFam Gene Tree for SSX9 (if available) |
Paralogs
for SSX9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SSX9 gene
- SSX2B2 SSX22 SSX62 SSX42 SSX72 SSX12 SSX52 SSX4B2
- SSX32
18/19 SIMAP similar genes for SSX9 using alignment to 1 protein entry: SSX9_HUMAN(see all similar genes):SSX10 SSX7 SYT-SSX2 SSX2B SSX3 SSX5
SSX6 SS18/SSX2 fusion SSX2 SSX4B SSX-HSTT SSX1
SSX4 SSX8 SYT-SSX1 SSX11 SS18/SSX1 fusion PRDM7_V2
SSX9 for paralogs About GeneDecksing
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Genomic Variants
for SSX9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SSX9 (48154885 - 48165732 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for SSX9
6 CNVs: 96641 83494 8304 67975 67974 7789 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSX9 |
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Disorders
/ Diseases
for SSX9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SSX9 for disorders About GeneDecksing
OMIM gene information: 300544
OMIM disorders: --
2  diseases for SSX9: About MalaCardssynovial sarcoma sarcoma
Export disorders for SSX9 gene to outside databases
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Publications
for SSX9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for SSX9 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SSX9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The SSX gene family: characterization of 9 complete genes. (PubMed id 12216073)1, 2, 3 Gure A.O.... Chen Y.-T. (2002)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SSX9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SSX9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing SSX9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SSX9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for SSX9 gene:
Search GeneIP for patents involving SSX9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SSX9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SSX9 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SSX9 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SSX9 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SSX9 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSX9 | | Browse OriGene Myc/DDK tagged cDNA clones in CMV expression vector | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SSX9 | | OriGene Custom Protein Services for SSX9 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SSX9 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSX9 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSX9 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSX9 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSX9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSX9 |
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| | | | Search Tocris compounds for SSX9 |
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 | | | SSX9 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for SSX9 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSX9 |
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