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SSX7 Gene

protein-coding   GIFtS: 46
GCID: GC0XM052674

Synovial Sarcoma, X Breakpoint 7

  See SSX7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Synovial Sarcoma, X Breakpoint 71 2
Protein SSX72

External Ids:    HGNC: 196531   Entrez Gene: 2806582   Ensembl: ENSG000001877547   OMIM: 3005425   UniProtKB: Q7RTT53   

Export aliases for SSX7 gene to outside databases

Previous GC identifers: GC0XU900002 GC0XM051324 GC0XM051639 GC0XM052556 GC0XM052689 GC0XM049800


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SSX7 Gene:
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins.
These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously
humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer
vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation
characteristically found in all synovial sarcomas. This gene appears not to be involved in this type of
chromosome translocation. (provided by RefSeq, Jul 2008)

GeneCards Summary for SSX7 Gene:
SSX7 (synovial sarcoma, X breakpoint 7) is a protein-coding gene. Diseases associated with SSX7 include synovial sarcoma, and sarcoma. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is SSX5.

UniProtKB/Swiss-Prot: SSX7_HUMAN, Q7RTT5
Function: Could act as a modulator of transcription




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011630.15  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SSX7 gene promoter:
         NF-1   C/EBPbeta   NCX/Ncx   C/EBPalpha   PPAR-gamma1   POU2F1b   Cart-1   POU2F1c   PPAR-gamma2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSSX7 promoter sequence
   Search Chromatin IP Primers for SSX7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SSX7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.23

SSX7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSX7 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM052674:  view genomic region     (about GC identifiers)

Start:
52,673,111 bp from pter      End:
52,683,950 bp from pter
Size:
10,840 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SSX7_HUMAN, Q7RTT5 (See protein sequence)
Recommended Name: Protein SSX7  
Size: 188 amino acids; 21591 Da

Explore the universe of human proteins at neXtProt for SSX7: NX_Q7RTT5

Explore proteomics data for SSX7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SSX7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775494.1  
    ENSEMBL proteins: 
     ENSP00000298181  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR003655 Krueppel-associated_box-rel
     IPR019041 SSXRD_motif
     IPR028804 SSX
     IPR001909 Krueppel-associated_box

    Graphical View of Domain Structure for InterPro Entry Q7RTT5

    ProtoNet protein and cluster: Q7RTT5

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: SSX7_HUMAN, Q7RTT5
    Similarity: Belongs to the SSX family
    Similarity: Contains 1 KRAB-related domain


    Find genes that share domains with SSX7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSX7_HUMAN, Q7RTT5
    Function: Could act as a modulator of transcription

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
         
    Find genes that share ontologies with SSX7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SSX7:
     Increased number of cells in m 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SSX7

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with SSX7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SSX7
    Interactions:

        Search GeneGlobe Interaction Network for SSX7

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for SSX7 (Q7RTT53 ENSP000002981814) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNAI2O436233I2D: score=1 
    ALDH18A1ENSP000003602684STRING: ENSP00000360268
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with SSX7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SSX7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SSX7 gene: 
    NM_173358.2  

    Unigene Cluster for SSX7:

    Synovial sarcoma, X breakpoint 7
    Hs.558712
    Unigene Representative Sequence: NM_173358
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000298181(uc004dqx.1)
    miRNA
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    2 AceView cDNA sequences:

    NM_173358 BK000687 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SSX7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SSX7 Expression
    About this image

    SSX7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SSX7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.558712

    UniProtKB/Swiss-Prot: SSX7_HUMAN, Q7RTT5
    Tissue specificity: Testis-specific. Expressed in a melanoma cell line

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSX7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for SSX7 (if available)
    TreeFam Gene Tree for SSX7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SSX7 gene
    SSX52  SSX2B2  SSX22  SSX42  SSX4B2  SSX12  SSX32  
    14 SIMAP similar genes for SSX7 using alignment to 1 protein entry:     SSX7_HUMAN:
    SSX9    SSX5    SSX10    SSX2B    SSX3    SSX2
    SSX6    SSX4B    SSX1    SSX8    SSX4    SYT-SSX2
    SYT-SSX1    PRDM9

    Find genes that share paralogs with SSX7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SSX7 (see all 255)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1383808451,2
    --52672628(+) GGAGGA/TTCGCT 1 -- ds50010--------
    rs1885507761,2
    --52672670(+) ACATAA/GACAGA 1 -- ds50010--------
    rs1928733831,2
    --52672690(+) CAAAAC/TCTTAA 1 -- ds50010--------
    rs24923191,2
    C,F--52672700(-) actaaT/Gttttt 1 -- ds50014Minor allele frequency- G:0.01NA 142
    rs2004604261,2
    --52673270(+) GTGTC-/TGTGTGT 1 -- ut310--------
    rs24923171,2
    H--52673686(-) AGAAGC/TAGAAC 1 -- ut314Minor allele frequency- T:0.00NS EA 418
    rs1858526501,2
    --52673700(+) CATGGA/GCATAT 1 -- ut310--------
    rs1903771621,2
    --52673752(+) AAGTGG/TCAGTG 1 -- int10--------
    rs1808578441,2
    --52673848(+) CACACA/GCCTTC 1 -- int10--------
    rs1444884301,2
    --52673907(+) GCCTGA/GGTTAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SSX7 (52673111 - 52683950 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SSX7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740170CNV Deletion23290073
    esv21492CNV Gain19812545

    Human Gene Mutation Database (HGMD): SSX7
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300542    OMIM disorders: --

    2 diseases for SSX7:    
    About MalaCards
    synovial sarcoma    sarcoma


    Find genes that share disorders with SSX7           About GenesLikeMe


    Export disorders for SSX7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SSX7 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SSX7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The SSX gene family: characterization of 9 complete genes. (PubMed id 12216073)1, 2, 3, 9 Gure A.O.... Chen Y.-T. (Int. J. Cancer 2002)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. Expressions of cancer-testis antigens in human hepatocellular carcinomas. (PubMed id 11179834)1 Chen C.H....Sheu J.C. (Cancer Lett. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 280658 HGNC: 19653 AceView: SSX7 Ensembl:ENSG00000187754 euGenes: HUgn280658
    ECgene: SSX7 H-InvDB: SSX7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SSX7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SSX7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SSX7 gene:
    Search GeneIP for patents involving SSX7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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