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Aliases for SSX7 Gene

Aliases for SSX7 Gene

  • Synovial Sarcoma, X Breakpoint 7 2 3 5

External Ids for SSX7 Gene

Previous GeneCards Identifiers for SSX7 Gene

  • GC0XU900002
  • GC0XM051324
  • GC0XM051639
  • GC0XM052556
  • GC0XM052689
  • GC0XM049800

Summaries for SSX7 Gene

Entrez Gene Summary for SSX7 Gene

  • The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This gene appears not to be involved in this type of chromosome translocation. [provided by RefSeq, Jul 2008]

GeneCards Summary for SSX7 Gene

SSX7 (Synovial Sarcoma, X Breakpoint 7) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is SSX3.

UniProtKB/Swiss-Prot for SSX7 Gene

  • Could act as a modulator of transcription.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSX7 Gene

Genomics for SSX7 Gene

Genomic Location for SSX7 Gene

Chromosome:
X
Start:
52,644,061 bp from pter
End:
52,654,900 bp from pter
Size:
10,840 bases
Orientation:
Minus strand

Genomic View for SSX7 Gene

Genes around SSX7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSX7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSX7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSX7 Gene

Proteins for SSX7 Gene

  • Protein details for SSX7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTT5-SSX7_HUMAN
    Recommended name:
    Protein SSX7
    Protein Accession:
    Q7RTT5

    Protein attributes for SSX7 Gene

    Size:
    188 amino acids
    Molecular mass:
    21591 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SSX7 Gene

Proteomics data for SSX7 Gene at MOPED

Post-translational modifications for SSX7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SSX7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SSX7 Gene

Domains & Families for SSX7 Gene

Protein Domains for SSX7 Gene

Suggested Antigen Peptide Sequences for SSX7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTT5

UniProtKB/Swiss-Prot:

SSX7_HUMAN :
  • Contains 1 KRAB-related domain.
  • Belongs to the SSX family.
Domain:
  • Contains 1 KRAB-related domain.
Family:
  • Belongs to the SSX family.
genes like me logo Genes that share domains with SSX7: view

No data available for Gene Families for SSX7 Gene

Function for SSX7 Gene

Molecular function for SSX7 Gene

UniProtKB/Swiss-Prot Function:
Could act as a modulator of transcription.
genes like me logo Genes that share phenotypes with SSX7: view

Animal Model Products

CRISPR Products

miRNA for SSX7 Gene

miRTarBase miRNAs that target SSX7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSX7 Gene

Localization for SSX7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSX7 Gene COMPARTMENTS Subcellular localization image for SSX7 gene
Compartment Confidence
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SSX7 Gene

Pathways & Interactions for SSX7 Gene

SuperPathways for SSX7 Gene

No Data Available

Interacting Proteins for SSX7 Gene

Selected Interacting proteins: Q7RTT5-SSX7_HUMAN for SSX7 Gene via I2D

Symbol External ID(s) Details
SNAI2

Gene Ontology (GO) - Biological Process for SSX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903507 negative regulation of nucleic acid-templated transcription IBA --
genes like me logo Genes that share ontologies with SSX7: view

No data available for Pathways by source and SIGNOR curated interactions for SSX7 Gene

Drugs & Compounds for SSX7 Gene

No Compound Related Data Available

Transcripts for SSX7 Gene

mRNA/cDNA for SSX7 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SSX7 Gene

No ASD Table

Relevant External Links for SSX7 Gene

GeneLoc Exon Structure for
SSX7
ECgene alternative splicing isoforms for
SSX7

Expression for SSX7 Gene

mRNA expression in normal human tissues for SSX7 Gene

SOURCE GeneReport for Unigene cluster for SSX7 Gene Hs.558712

mRNA Expression by UniProt/SwissProt for SSX7 Gene

Q7RTT5-SSX7_HUMAN
Tissue specificity: Testis-specific. Expressed in a melanoma cell line.
genes like me logo Genes that share expression patterns with SSX7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SSX7 Gene

Orthologs for SSX7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SSX7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SSX5 36
  • 30 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 48 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm14459 36
  • 30 (a)
ManyToMany
Gm21876 36
  • 40 (a)
ManyToMany
Gm5751 36
  • 33 (a)
ManyToMany
Gm6592 36
  • 31 (a)
ManyToMany
Ssx9 36
  • 31 (a)
ManyToMany
Ssxa1 36
  • 43 (a)
ManyToMany
Ssxb1 36
  • 32 (a)
ManyToMany
Ssxb10 36
  • 32 (a)
ManyToMany
Ssxb2 36
  • 30 (a)
ManyToMany
Ssxb3 36
  • 32 (a)
ManyToMany
Ssxb5 36
  • 33 (a)
ManyToMany
Ssxb6 36
  • 27 (a)
ManyToMany
Ssxb8 36
  • 33 (a)
ManyToMany
Ssxb9 36
  • 31 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia SSX7 36
  • 91 (a)
OneToOne
Species with no ortholog for SSX7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SSX7 Gene

ENSEMBL:
Gene Tree for SSX7 (if available)
TreeFam:
Gene Tree for SSX7 (if available)

Paralogs for SSX7 Gene

Paralogs for SSX7 Gene

(14) SIMAP similar genes for SSX7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SSX7: view

Variants for SSX7 Gene

Sequence variations from dbSNP and Humsavar for SSX7 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs3122210 - 52,652,926(+) TCTCC(A/C/G)AGGAT reference, missense
rs2492317 -- 52,644,636(-) AGAAG(C/T)AGAAC utr-variant-3-prime
rs2492318 -- 52,643,673(-) acagg(A/C)atgca downstream-variant-500B
rs2492319 -- 52,643,650(-) actaa(G/T)ttttt downstream-variant-500B
rs2811831 -- 52,644,724(-) GAGTT(A/G)TCACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSX7 Gene

Variant ID Type Subtype PubMed ID
esv2740170 CNV Deletion 23290073
esv21492 CNV Gain 19812545

Variation tolerance for SSX7 Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.20; 62.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSX7 Gene

Human Gene Mutation Database (HGMD)
SSX7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSX7 Gene

Disorders for SSX7 Gene

Relevant External Links for SSX7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSX7

No disorders were found for SSX7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSX7 Gene

Publications for SSX7 Gene

  1. The SSX gene family: characterization of 9 complete genes. (PMID: 12216073) Gure A.O. … Chen Y.-T. (Int. J. Cancer 2002) 2 3 4 23 67
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3
  3. Expressions of cancer-testis antigens in human hepatocellular carcinomas. (PMID: 11179834) Chen C.H. … Sheu J.C. (Cancer Lett. 2001) 3

Products for SSX7 Gene

Sources for SSX7 Gene

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