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Aliases for SSX6 Gene

Aliases for SSX6 Gene

  • SSX Family Member 6, Pseudogene 2 3 5
  • Synovial Sarcoma, X Breakpoint 6 (Pseudogene) 2 3
  • SSX Family Pseudogene 2 2 3
  • Synovial Sarcoma X Breakpoint 6 Protein 3
  • Synovial Sarcoma, X Breakpoint 6 2
  • SSX2 Pseudogene 3
  • DJ54B20.1 3
  • PsiSSX2 3
  • SSX6P 3
  • SSXP2 3

External Ids for SSX6 Gene

Previous HGNC Symbols for SSX6 Gene

  • SSXP2

Previous GeneCards Identifiers for SSX6 Gene

  • GC0XU900001
  • GC0XP046793
  • GC0XP047013
  • GC0XP047723
  • GC0XP047852
  • GC0XP047967

Summaries for SSX6 Gene

Entrez Gene Summary for SSX6 Gene

  • This gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This gene is classified as a pseudogene because a splice donor in the 3' UTR has changed compared to other family members, rendering the transcript a candidate for nonsense-mediated mRNA decay (NMD). [provided by RefSeq, Aug 2009]

GeneCards Summary for SSX6 Gene

SSX6 (SSX Family Member 6, Pseudogene) is a Pseudogene. Diseases associated with SSX6 include Sarcoma. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for SSX6 Gene

  • Could act as a modulator of transcription.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSX6 Gene

Genomics for SSX6 Gene

Regulatory Elements for SSX6 Gene

Enhancers for SSX6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG048083 0.4 ENCODE 0.3 -24.1 -24136 0.1 GATA3 TCF7L2 ZNF630 SSX6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SSX6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SSX6 Gene

Chromosome:
X
Start:
48,107,982 bp from pter
End:
48,120,686 bp from pter
Size:
12,705 bases
Orientation:
Plus strand

Genomic View for SSX6 Gene

Genes around SSX6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSX6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSX6 Gene

Proteins for SSX6 Gene

  • Protein details for SSX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTT6-SSX6_HUMAN
    Recommended name:
    Putative protein SSX6
    Protein Accession:
    Q7RTT6

    Protein attributes for SSX6 Gene

    Size:
    188 amino acids
    Molecular mass:
    21688 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SSX6 Gene

Post-translational modifications for SSX6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SSX6 Gene

Domains & Families for SSX6 Gene

Protein Domains for SSX6 Gene

Suggested Antigen Peptide Sequences for SSX6 Gene

Graphical View of Domain Structure for InterPro Entry

Q7RTT6

UniProtKB/Swiss-Prot:

SSX6_HUMAN :
  • Belongs to the SSX family.
Family:
  • Belongs to the SSX family.
genes like me logo Genes that share domains with SSX6: view

No data available for Gene Families for SSX6 Gene

Function for SSX6 Gene

Molecular function for SSX6 Gene

UniProtKB/Swiss-Prot Function:
Could act as a modulator of transcription.

Gene Ontology (GO) - Molecular Function for SSX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003714 transcription corepressor activity IBA --
genes like me logo Genes that share ontologies with SSX6: view
genes like me logo Genes that share phenotypes with SSX6: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SSX6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SSX6 Gene

Localization for SSX6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSX6 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for SSX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SSX6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SSX6 Gene

Pathways & Interactions for SSX6 Gene

No Data Available

Interacting Proteins for SSX6 Gene

Gene Ontology (GO) - Biological Process for SSX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:1903507 negative regulation of nucleic acid-templated transcription IBA --
genes like me logo Genes that share ontologies with SSX6: view

No data available for Pathways by source and SIGNOR curated interactions for SSX6 Gene

Drugs & Compounds for SSX6 Gene

No Compound Related Data Available

Transcripts for SSX6 Gene

mRNA/cDNA for SSX6 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SSX6 Gene

Synovial sarcoma, X breakpoint 6 (pseudogene):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SSX6

Alternative Splicing Database (ASD) splice patterns (SP) for SSX6 Gene

No ASD Table

Relevant External Links for SSX6 Gene

GeneLoc Exon Structure for
SSX6
ECgene alternative splicing isoforms for
SSX6

Expression for SSX6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSX6 Gene

mRNA differential expression in normal tissues according to GTEx for SSX6 Gene

This gene is overexpressed in Testis (x26.5) and Spleen (x17.6).

NURSA nuclear receptor signaling pathways regulating expression of SSX6 Gene:

SSX6

SOURCE GeneReport for Unigene cluster for SSX6 Gene:

Hs.511998

mRNA Expression by UniProt/SwissProt for SSX6 Gene:

Q7RTT6-SSX6_HUMAN
Tissue specificity: Not detected in any normal tissues. Expressed in a melanoma cell line.
genes like me logo Genes that share expression patterns with SSX6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSX6 Gene

Orthologs for SSX6 Gene

Evolution for SSX6 Gene

ENSEMBL:
Gene Tree for SSX6 (if available)
TreeFam:
Gene Tree for SSX6 (if available)

No data available for Orthologs for SSX6 Gene

Paralogs for SSX6 Gene

(16) SIMAP similar genes for SSX6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SSX6: view

No data available for Paralogs for SSX6 Gene

Variants for SSX6 Gene

Sequence variations from dbSNP and Humsavar for SSX6 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1010030 -- 48,110,911(-) GAGAC(A/G)GAGAG intron-variant
rs111235177 -- 48,119,973(+) GAAGG(C/T)GTGTG intron-variant
rs111274922 -- 48,113,237(+) TCATC(C/G)CGAAG nc-transcript-variant
rs111286043 -- 48,110,146(+) AAGGA(C/G)CAGGG intron-variant
rs111353407 -- 48,109,900(+) GTGGC(C/T)GGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSX6 Gene

Variant ID Type Subtype PubMed ID
dgv17n29 CNV gain+loss 16826518
dgv2286e212 CNV gain 25503493
dgv2287e212 CNV loss 25503493
dgv268e55 CNV loss 17911159
dgv37n14 CNV gain 18776910
esv25781 CNV gain 19812545
esv2752324 CNV gain 17911159
esv2758866 CNV gain+loss 17122850
esv32909 CNV gain+loss 17666407
esv3412488 CNV duplication 20981092
esv34308 CNV gain 17911159
esv34932 CNV gain 17911159
nsv438131 CNV loss 16468122
nsv442804 CNV gain+loss 18776908
nsv470351 CNV loss 18288195
nsv470352 CNV gain 18288195
nsv471601 CNV gain 15918152
nsv517350 CNV gain+loss 19592680
nsv519165 CNV loss 19592680
nsv521227 CNV gain 19592680
nsv6890 CNV deletion 18451855
nsv6892 CNV insertion 18451855
nsv818025 CNV gain+loss 17921354
nsv9940 CNV gain 18304495
nsv9941 CNV gain 18304495

Relevant External Links for SSX6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSX6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SSX6 Gene

Disorders for SSX6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SSX6 Gene - From: GeneCards

Disorder Aliases PubMed IDs
sarcoma
  • connective and soft tissue neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search SSX6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SSX6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSX6
genes like me logo Genes that share disorders with SSX6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSX6 Gene

Publications for SSX6 Gene

  1. The SSX gene family: characterization of 9 complete genes. (PMID: 12216073) Gure A.O. … Chen Y.-T. (Int. J. Cancer 2002) 2 3 4 64
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  3. The (epi)genetics of human synovial sarcoma. (PMID: 17117414) de Bruijn D.R. … van Kessel A.G. (Genes Chromosomes Cancer 2007) 3 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  5. Molecular mechanisms underlying human synovial sarcoma development. (PMID: 11107170) dos Santos N.R. … van Kessel A.G. (Genes Chromosomes Cancer 2001) 3 64

Products for SSX6 Gene

Sources for SSX6 Gene

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