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Aliases for SSX6 Gene

Aliases for SSX6 Gene

  • SSX Family Member 6, Pseudogene 2 3 5
  • Synovial Sarcoma, X Breakpoint 6 (Pseudogene) 2 3
  • SSX Family Pseudogene 2 2 3
  • Synovial Sarcoma X Breakpoint 6 Protein 3
  • Synovial Sarcoma, X Breakpoint 6 2
  • SSX2 Pseudogene 3
  • DJ54B20.1 3
  • PsiSSX2 3
  • SSX6P 3
  • SSXP2 3

External Ids for SSX6 Gene

Previous HGNC Symbols for SSX6 Gene

  • SSXP2

Previous GeneCards Identifiers for SSX6 Gene

  • GC0XU900001
  • GC0XP046793
  • GC0XP047013
  • GC0XP047723
  • GC0XP047852
  • GC0XP047967

Summaries for SSX6 Gene

Entrez Gene Summary for SSX6 Gene

  • This gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This gene is classified as a pseudogene because a splice donor in the 3' UTR has changed compared to other family members, rendering the transcript a candidate for nonsense-mediated mRNA decay (NMD). [provided by RefSeq, Aug 2009]

GeneCards Summary for SSX6 Gene

SSX6 (SSX Family Member 6, Pseudogene) is a Pseudogene. Diseases associated with SSX6 include Sarcoma. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for SSX6 Gene

  • Could act as a modulator of transcription.

Additional gene information for SSX6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSX6 Gene

Genomics for SSX6 Gene

GeneHancer (GH) Regulatory Elements for SSX6 Gene

Promoters and enhancers for SSX6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI048083 Enhancer 0.4 ENCODE 0.3 -24.1 -24135 0.1 CTCF GATA3 TCF7L2 ZNF630 SSX6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SSX6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SSX6 gene promoter:

Genomic Locations for SSX6 Gene

Genomic Locations for SSX6 Gene
12,705 bases
Plus strand

Genomic View for SSX6 Gene

Genes around SSX6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSX6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSX6 Gene

Proteins for SSX6 Gene

  • Protein details for SSX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative protein SSX6
    Protein Accession:

    Protein attributes for SSX6 Gene

    188 amino acids
    Molecular mass:
    21688 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SSX6 Gene

Post-translational modifications for SSX6 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SSX6 Gene

Domains & Families for SSX6 Gene

Protein Domains for SSX6 Gene

Suggested Antigen Peptide Sequences for SSX6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SSX family.
  • Belongs to the SSX family.
genes like me logo Genes that share domains with SSX6: view

No data available for Gene Families for SSX6 Gene

Function for SSX6 Gene

Molecular function for SSX6 Gene

UniProtKB/Swiss-Prot Function:
Could act as a modulator of transcription.

Gene Ontology (GO) - Molecular Function for SSX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003714 transcription corepressor activity IBA --
genes like me logo Genes that share ontologies with SSX6: view
genes like me logo Genes that share phenotypes with SSX6: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SSX6 Gene

Localization for SSX6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSX6 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for SSX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SSX6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for SSX6 Gene

Pathways & Interactions for SSX6 Gene

No Data Available

Interacting Proteins for SSX6 Gene

Gene Ontology (GO) - Biological Process for SSX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:1903507 negative regulation of nucleic acid-templated transcription IBA --
genes like me logo Genes that share ontologies with SSX6: view

No data available for Pathways by source and SIGNOR curated interactions for SSX6 Gene

Drugs & Compounds for SSX6 Gene

No Compound Related Data Available

Transcripts for SSX6 Gene

mRNA/cDNA for SSX6 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SSX6 Gene

Synovial sarcoma, X breakpoint 6 (pseudogene):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSX6 Gene

No ASD Table

Relevant External Links for SSX6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SSX6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSX6 Gene

mRNA differential expression in normal tissues according to GTEx for SSX6 Gene

This gene is overexpressed in Testis (x26.5) and Spleen (x17.6).

NURSA nuclear receptor signaling pathways regulating expression of SSX6 Gene:


SOURCE GeneReport for Unigene cluster for SSX6 Gene:


mRNA Expression by UniProt/SwissProt for SSX6 Gene:

Tissue specificity: Not detected in any normal tissues. Expressed in a melanoma cell line.
genes like me logo Genes that share expression patterns with SSX6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSX6 Gene

Orthologs for SSX6 Gene

Evolution for SSX6 Gene

Gene Tree for SSX6 (if available)
Gene Tree for SSX6 (if available)

No data available for Orthologs for SSX6 Gene

Paralogs for SSX6 Gene

(16) SIMAP similar genes for SSX6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SSX6: view

No data available for Paralogs for SSX6 Gene

Variants for SSX6 Gene

Sequence variations from dbSNP and Humsavar for SSX6 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1010030 -- 48,110,911(+) C/T intron_variant
rs111235177 -- 48,119,973(+) C/T intron_variant
rs111274922 -- 48,113,237(+) C/G non_coding_transcript_variant
rs111286043 -- 48,110,146(+) C/G intron_variant
rs111353407 -- 48,109,900(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SSX6 Gene

Variant ID Type Subtype PubMed ID
dgv17n29 CNV gain+loss 16826518
dgv2286e212 CNV gain 25503493
dgv2287e212 CNV loss 25503493
dgv268e55 CNV loss 17911159
dgv37n14 CNV gain 18776910
esv25781 CNV gain 19812545
esv2752324 CNV gain 17911159
esv2758866 CNV gain+loss 17122850
esv32909 CNV gain+loss 17666407
esv3412488 CNV duplication 20981092
esv34308 CNV gain 17911159
esv34932 CNV gain 17911159
nsv438131 CNV loss 16468122
nsv442804 CNV gain+loss 18776908
nsv470351 CNV loss 18288195
nsv470352 CNV gain 18288195
nsv471601 CNV gain 15918152
nsv517350 CNV gain+loss 19592680
nsv519165 CNV loss 19592680
nsv521227 CNV gain 19592680
nsv6890 CNV deletion 18451855
nsv6892 CNV insertion 18451855
nsv818025 CNV gain+loss 17921354
nsv9940 CNV gain 18304495
nsv9941 CNV gain 18304495

Additional Variant Information for SSX6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SSX6 Gene

Disorders for SSX6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SSX6 Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • connective and soft tissue neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search SSX6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SSX6

genes like me logo Genes that share disorders with SSX6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSX6 Gene

Publications for SSX6 Gene

  1. The SSX gene family: characterization of 9 complete genes. (PMID: 12216073) Güre AO … Chen YT (International journal of cancer 2002) 2 3 4 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The (epi)genetics of human synovial sarcoma. (PMID: 17117414) de Bruijn DR … van Kessel AG (Genes, chromosomes & cancer 2007) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for SSX6 Gene

Sources for SSX6 Gene

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