SSX5 Gene
protein-coding GIFtS: 50
GCID: GC0XM048045
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synovial sarcoma, X breakpoint 5
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Aliases
for SSX5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Synovial Sarcoma, X Breakpoint 51 2 | | Protein SSX52 |
Export aliases for SSX5 gene to outside databasesPrevious GC identifers: GC0XM046848 GC0XM046306 GC0XM047091 GC0XM047801 GC0XM047930 GC0XM045758 |
Summaries
for SSX5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SSX5:
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. Theseproteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral andcellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-basedimmunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found inall synovial sarcomas. This gene appears not to be involved in this type of chromosome translocation. Two transcriptvariants encoding distinct isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SSX5_HUMAN, O60225Function: Could act as a modulator of transcription
Gene Wiki entry for SSX5
|
Genomic Views
for SSX5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_079573.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SSX5 gene promoter:
HOXA9B HOXA9 FOXF2 ATF-2 NCX/Ncx CUTL1 C/EBPalpha Sox9 Meis-1 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SSX5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSX5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23SSX5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM048045: view genomic region
(about GC identifiers)
Start:
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48,045,656 bp from pter |
End:
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48,056,199 bp from pter |
Size:
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10,544 bases |
Orientation:
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minus strand |
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Proteins
for SSX5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SSX5_HUMAN, O60225 (See
protein sequence)Recommended Name: Protein SSX5 Size: 188 amino acids; 21660 Da
Secondary accessions: Q5JQ59 Q5JQ60 Q96AW3Alternative splicing: 2 isoforms: O60225-1 O60225-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SSX5: NX_O60225
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60225
SSX5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_066295.3 NP_783729.1
ENSEMBL proteins: ENSP00000312415 ENSP00000366122 ENSP00000385051 ENSP00000290558
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
SSX5 for ontologies About GeneDecksing
SSX5 Antibody Products:
Assay Products for SSX5: |
Protein
Domains /
Families
for SSX5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SSX5 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O60225ProtoNet protein and cluster: O60225 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: SSX5_HUMAN, O60225Similarity: Belongs to the SSX familySimilarity: Contains 1 KRAB-related domain |
Function
for SSX5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SSX5_HUMAN, O60225Function: Could act as a modulator of transcription Genatlas biochemistry entry for SSX5:protein SSX5 with homology to Kruppel associated box,KRAB,not implicated in t(X;18) synovial sarcoma
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSX5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSX5 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SSX5 (NM_021015) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SSX5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSX5 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- |
SSX5 for ontologies About GeneDecksing
|
Pathways & Interactions
for SSX5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SSX5
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for SSX5 (O602253 ENSP000003124154) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
SSX5 for ontologies About GeneDecksing
|
Drugs & Compounds
for SSX5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SSX5
Search CenterWatch for drugs/clinical trials and news about SSX5
|
Transcripts
for SSX5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SSX5 gene (2 alternative transcripts): NM_021015.3 NM_175723.1 Unigene Cluster for SSX5: Synovial sarcoma, X breakpoint 5 Hs.166198 [show with all ESTs]Unigene Representative Sequence: NM_0210154 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000311798(uc004diz.1) ENST00000376923 ENST00000403001 ENST00000347757(uc004dja.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSX5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSX5 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SSX5 (NM_021015) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SSX5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSX5 |
Additional cDNA sequence: BC016640.2 U90842.1 2 DOTS entries: DT.92450025 DT.100809879 6 AceView cDNA sequences: NM_175723 NM_021015 BU178938 BC016640 BE896093 U90842
GeneLoc Exon Structure
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Expression
for SSX5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SSX5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SSX5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SSX5
SOURCE GeneReport for Unigene cluster: Hs.166198
SABiosciences Custom PCR Arrays for SSX5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SSX5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SSX5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSX5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSX5 |
Orthologs
for SSX5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for SSX5 (if available)
TreeFam Gene Tree for SSX5 (if available) |
Paralogs
for SSX5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SSX5 gene
- SSX2B2 SSX22 SSX62 SSX42 SSX72 SSX12 SSX92 SSX4B2
- SSX32
18 SIMAP similar genes for SSX5 using alignment to 2 protein entries: SSX5_HUMAN (see all proteins):SSX10 SSX2B SSX7 SSX3 SSX6 SSX9
SSX11 SS18/SSX2 fusion SSX1 SSX4B SS18/SSX1 fusion SSX2
SSX8 SSX4 SYT-SSX2 SYT-SSX1 SSX-HSTT PRDM9
SSX5 for paralogs About GeneDecksing
5/10 Pseudogenes.org Pseudogenes for SSX5 (see all 10)
PGOHUM00000243755 PGOHUM00000241281 PGOHUM00000250049 PGOHUM00000250050 PGOHUM00000260956
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Genomic Variants
for SSX5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SSX5 (48045656 - 48056199 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for SSX5
10 CNVs: 96641 4149 67975 34577 0823 7789 8304 2277 3250 67974
Locus Specific Mutation Databases (LSDB): SSX5
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSX5 |
|
Disorders
/ Diseases
for SSX5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SSX5 for disorders About GeneDecksing
OMIM gene information: 300327
OMIM disorders: --
5  diseases for SSX5: About MalaCardssynovial sarcoma sarcoma hepatocellular carcinoma melanoma
carcinoma
1 disease from the University of Copenhagen DISEASES database for SSX5:Synovial sarcoma 2 Novoseek disease relationships for SSX5 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| melanoma |
46.1 |
3 |
12007189 (1), 10749136 (1), 9378559 (1) |
| cancer |
1.82 |
1 |
10749136 (1) |
Export disorders for SSX5 gene to outside databases
|
Publications
for SSX5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SSX5 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with SSX5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- SSX: a multigene family with several members transcribed in normal testis and human cancer. (PubMed id 9378559)1, 2, 9 Gure A.O....Chen Y.T. (1997)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PubMed id 12007189)1, 9 de Bruijn D.R.H....van Kessel A.G. (2002)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- Expression of cancer-testis antigen (CTA) in tumor tissues and peripheral blood of Chinese patients with hepatocellular carcinoma. (PubMed id 16546222)1 Wu L.Q....Yang J.Y. (2006)
- The SSX gene family: characterization of 9 complete genes. (PubMed id 12216073)1 Gure A.O.... Chen Y.-T. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Molecular mechanisms underlying human synovial sarcoma development. (PubMed id 11107170)1 dos Santos N.R....van Kessel A.G. (2001)
- Expressions of cancer-testis antigens in human hepatocellular carcinomas. (PubMed id 11179834)1 Chen C.H....Sheu J.C. (2001)
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External Searches for SSX5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SSX5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SSX5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SSX5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SSX5 gene:
Search GeneIP for patents involving SSX5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SSX5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for SSX5 | | OriGene Custom Protein Services for SSX5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SSX5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSX5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSX5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSX5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSX5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSX5 |
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 | | | SSX5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for SSX5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSX5 |
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