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Aliases for SSX5 Gene

Aliases for SSX5 Gene

  • Synovial Sarcoma, X Breakpoint 5 2 3 5

External Ids for SSX5 Gene

Previous GeneCards Identifiers for SSX5 Gene

  • GC0XM046848
  • GC0XM046306
  • GC0XM047091
  • GC0XM047801
  • GC0XM047930
  • GC0XM048045
  • GC0XM045758

Summaries for SSX5 Gene

Entrez Gene Summary for SSX5 Gene

  • The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. While some of the related SSX genes are involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas, this gene does not appear to be involved in such translocations. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for SSX5 Gene

SSX5 (Synovial Sarcoma, X Breakpoint 5) is a Protein Coding gene. Diseases associated with SSX5 include Sarcoma and Synovium Cancer. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is SSX3.

UniProtKB/Swiss-Prot for SSX5 Gene

  • Could act as a modulator of transcription.

Gene Wiki entry for SSX5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSX5 Gene

Genomics for SSX5 Gene

Regulatory Elements for SSX5 Gene


Genomic Location for SSX5 Gene

Chromosome:
X
Start:
48,186,220 bp from pter
End:
48,277,578 bp from pter
Size:
91,359 bases
Orientation:
Minus strand

Genomic View for SSX5 Gene

Genes around SSX5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSX5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSX5 Gene

Proteins for SSX5 Gene

  • Protein details for SSX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60225-SSX5_HUMAN
    Recommended name:
    Protein SSX5
    Protein Accession:
    O60225
    Secondary Accessions:
    • Q5JQ59
    • Q5JQ60
    • Q96AW3

    Protein attributes for SSX5 Gene

    Size:
    188 amino acids
    Molecular mass:
    21660 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SSX5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSX5 Gene

Proteomics data for SSX5 Gene at MOPED

Post-translational modifications for SSX5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SSX5 Gene

No data available for DME Specific Peptides for SSX5 Gene

Domains & Families for SSX5 Gene

Protein Domains for SSX5 Gene

Suggested Antigen Peptide Sequences for SSX5 Gene

Graphical View of Domain Structure for InterPro Entry

O60225

UniProtKB/Swiss-Prot:

SSX5_HUMAN :
  • Contains 1 KRAB-related domain.
  • Belongs to the SSX family.
Domain:
  • Contains 1 KRAB-related domain.
Family:
  • Belongs to the SSX family.
genes like me logo Genes that share domains with SSX5: view

No data available for Gene Families for SSX5 Gene

Function for SSX5 Gene

Molecular function for SSX5 Gene

GENATLAS Biochemistry:
protein SSX5 with homology to Kruppel associated box,KRAB,not implicated in t(X;18) synovial sarcoma
UniProtKB/Swiss-Prot Function:
Could act as a modulator of transcription.

Gene Ontology (GO) - Molecular Function for SSX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with SSX5: view
genes like me logo Genes that share phenotypes with SSX5: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSX5 Gene

Localization for SSX5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSX5 Gene COMPARTMENTS Subcellular localization image for SSX5 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SSX5 Gene

Pathways & Interactions for SSX5 Gene

SuperPathways for SSX5 Gene

No Data Available

Interacting Proteins for SSX5 Gene

Selected Interacting proteins: O60225-SSX5_HUMAN for SSX5 Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for SSX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903507 negative regulation of nucleic acid-templated transcription IBA --
genes like me logo Genes that share ontologies with SSX5: view

No data available for Pathways by source and SIGNOR curated interactions for SSX5 Gene

Drugs & Compounds for SSX5 Gene

No Compound Related Data Available

Transcripts for SSX5 Gene

mRNA/cDNA for SSX5 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SSX5 Gene

Synovial sarcoma, X breakpoint 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSX5 Gene

No ASD Table

Relevant External Links for SSX5 Gene

GeneLoc Exon Structure for
SSX5
ECgene alternative splicing isoforms for
SSX5

Expression for SSX5 Gene

mRNA expression in normal human tissues for SSX5 Gene

mRNA differential expression in normal tissues according to GTEx for SSX5 Gene

This gene is overexpressed in Testis (x39.4).

Protein differential expression in normal tissues from HIPED for SSX5 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SSX5 Gene



SOURCE GeneReport for Unigene cluster for SSX5 Gene Hs.166198

genes like me logo Genes that share expression patterns with SSX5: view

Protein tissue co-expression partners for SSX5 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SSX5 Gene

Orthologs for SSX5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SSX5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100608018 35
  • 93.01 (n)
  • 84.72 (a)
-- 36
  • 69 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia SSX5 36
  • 28 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 44 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm14459 36
  • 31 (a)
ManyToMany
Gm21876 36
  • 43 (a)
ManyToMany
Gm5751 36
  • 34 (a)
ManyToMany
Gm6592 36
  • 30 (a)
ManyToMany
Ssx9 36
  • 29 (a)
ManyToMany
Ssxa1 36
  • 43 (a)
ManyToMany
Ssxb1 36
  • 31 (a)
ManyToMany
Ssxb10 36
  • 32 (a)
ManyToMany
Ssxb2 36
  • 28 (a)
ManyToMany
Ssxb3 36
  • 31 (a)
ManyToMany
Ssxb5 36
  • 33 (a)
ManyToMany
Ssxb6 36
  • 28 (a)
ManyToMany
Ssxb8 36
  • 32 (a)
ManyToMany
Ssxb9 36
  • 31 (a)
ManyToMany
Species with no ortholog for SSX5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SSX5 Gene

ENSEMBL:
Gene Tree for SSX5 (if available)
TreeFam:
Gene Tree for SSX5 (if available)

Paralogs for SSX5 Gene

Paralogs for SSX5 Gene

(17) SIMAP similar genes for SSX5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SSX5: view

Variants for SSX5 Gene

Sequence variations from dbSNP and Humsavar for SSX5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs4824675 - 48,195,304(+) CTTCT(A/C/G)TGGTA reference, missense, stop-gained
rs2314191 -- 48,186,596(+) CAAAC(C/T)GAAAT downstream-variant-500B, utr-variant-3-prime
rs2314320 -- 48,189,236(+) aaata(A/G)ccttc intron-variant
rs2314321 -- 48,189,261(+) gccat(C/G)tagga intron-variant
rs3048148 -- 48,189,407(+) TGTCT(-/GTTGTGT)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSX5 Gene

Variant ID Type Subtype PubMed ID
dgv2442e1 CNV Complex 17122850
dgv14n29 CNV Complex 16826518
nsv471601 CNV Gain 15918152
dgv2444e1 CNV Complex 17122850
esv2752324 CNV Gain 17911159
esv25781 CNV Gain 19812545
esv32909 CNV Gain+Loss 17666407
nsv517350 CNV Gain+Loss 19592680
nsv519165 CNV Loss 19592680
nsv521227 CNV Gain 19592680
esv2740145 CNV Deletion 23290073
esv2671998 CNV Deletion 23128226

Variation tolerance for SSX5 Gene

Residual Variation Intolerance Score: 95.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SSX5 Gene

Disorders for SSX5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SSX5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
sarcoma
  • connective and soft tissue neoplasm
synovium cancer
  • malignant tumor of synovium
- elite association - COSMIC cancer census association via MalaCards
Search SSX5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SSX5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSX5
genes like me logo Genes that share disorders with SSX5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSX5 Gene

Publications for SSX5 Gene

  1. SSX: a multigene family with several members transcribed in normal testis and human cancer. (PMID: 9378559) Gure A.O. … Chen Y.-T. (Int. J. Cancer 1997) 3 4 23 67
  2. The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PMID: 12007189) de Bruijn D.R.H. … van Kessel A.G. (Genes Chromosomes Cancer 2002) 3 23
  3. Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines. (PMID: 10749136) dos Santos N.R. … Geurts van Kessel A. (Cancer Res. 2000) 3 23
  4. Detection of the SYT-SSX fusion transcripts in formaldehyde-fixed, paraffin-embedded tissue: a reverse transcription polymerase chain reaction amplification assay useful in the diagnosis of synovial sarcoma. (PMID: 9688183) Lasota J. … Miettinen M. (Mod. Pathol. 1998) 3 23
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for SSX5 Gene

Sources for SSX5 Gene

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