Aliases for SSX4B Gene
External Ids for SSX4B Gene
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4B, represents the more centromeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SSX4B Gene
SSX4B (Synovial Sarcoma, X Breakpoint 4B) is a Protein Coding gene. Diseases associated with SSX4B include sarcoma. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is SSX4.
UniProtKB/Swiss-Prot for SSX4B Gene
Could act as a modulator of transcription