Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SSX4B Gene

Aliases for SSX4B Gene

  • Synovial Sarcoma, X Breakpoint 4B 2 3
  • Cancer/Testis Antigen 5.4 3 4
  • CT5.4 3 4
  • OTTHUMT00000056510 3
  • Protein SSX4 3
  • SSX4 SSX4B 4
  • SSX4A 4

External Ids for SSX4B Gene

Summaries for SSX4B Gene

Entrez Gene Summary for SSX4B Gene

  • The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4B, represents the more centromeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SSX4B Gene

SSX4B (Synovial Sarcoma, X Breakpoint 4B) is a Protein Coding gene. Diseases associated with SSX4B include sarcoma. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is SSX4.

UniProtKB/Swiss-Prot for SSX4B Gene

  • Could act as a modulator of transcription

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSX4B Gene

Genomics for SSX4B Gene

Genomic Location for SSX4B Gene

Start:
48,402,078 bp from pter
End:
48,411,910 bp from pter
Size:
9,833 bases
Orientation:
Minus strand

Genomic View for SSX4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSX4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSX4B Gene

Regulatory Elements for SSX4B Gene

Proteins for SSX4B Gene

  • Protein details for SSX4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60224-SSX4_HUMAN
    Recommended name:
    Protein SSX4
    Protein Accession:
    O60224
    Secondary Accessions:
    • A8MYD4
    • B2RPE3
    • Q3SYD4
    • Q5JQZ0
    • Q9UJU9

    Protein attributes for SSX4B Gene

    Size:
    188 amino acids
    Molecular mass:
    21858 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI03865.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence={ECO:0000305};

    Alternative splice isoforms for SSX4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSX4B Gene

Proteomics data for SSX4B Gene at MOPED

Post-translational modifications for SSX4B Gene

No Post-translational modifications

Other Protein References for SSX4B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SSX4B Gene

Domains for SSX4B Gene

Protein Domains for SSX4B Gene

UniProtKB/Swiss-Prot:

SSX4_HUMAN
Domain:
  • Contains 1 KRAB-related domain.:
    • O60224
Family:
  • Belongs to the SSX family.:
    • O60224
genes like me logo Genes that share domains with SSX4B: view

No data available for Gene Families for SSX4B Gene

Function for SSX4B Gene

Molecular function for SSX4B Gene

UniProtKB/Swiss-Prot Function: Could act as a modulator of transcription

Gene Ontology (GO) - Molecular Function for SSX4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with SSX4B: view

Phenotypes for SSX4B Gene

GenomeRNAi human phenotypes for SSX4B:
genes like me logo Genes that share phenotypes with SSX4B: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SSX4B Gene

Localization for SSX4B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSX4B Gene COMPARTMENTS Subcellular localization image for SSX4B gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SSX4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SSX4B: view

Pathways for SSX4B Gene

SuperPathways for SSX4B Gene

No Data Available

Interacting Proteins for SSX4B Gene

Selected Interacting proteins: O60224-SSX4_HUMAN for SSX4B Gene via MINT I2D

Gene Ontology (GO) - Biological Process for SSX4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with SSX4B: view

No data available for Pathways by source for SSX4B Gene

Transcripts for SSX4B Gene

mRNA/cDNA for SSX4B Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SSX4B Gene

Synovial sarcoma, X breakpoint 4B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSX4B Gene

No ASD Table

Relevant External Links for SSX4B Gene

GeneLoc Exon Structure for
SSX4B
ECgene alternative splicing isoforms for
SSX4B

Expression for SSX4B Gene

mRNA expression in normal human tissues for SSX4B Gene

mRNA differential expression in normal tissues according to GTEx for SSX4B Gene

This gene is overexpressed in Testis (53.0).

SOURCE GeneReport for Unigene cluster for SSX4B Gene Hs.558402

genes like me logo Genes that share expressions with SSX4B: view

Orthologs for SSX4B Gene

This gene was present in the common ancestor of mammals.

Orthologs for SSX4B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SSX5 36
  • 63.54 (n)
  • 41.99 (a)
dog
(Canis familiaris)
Mammalia LOC612524 36
  • 69 (n)
  • 51.61 (a)
mouse
(Mus musculus)
Mammalia Ssxb2 36
  • 66.29 (n)
  • 56.18 (a)
Species with no ortholog for SSX4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SSX4B Gene

ENSEMBL:
Gene Tree for SSX4B (if available)
TreeFam:
Gene Tree for SSX4B (if available)

Paralogs for SSX4B Gene

Paralogs for SSX4B Gene

Selected SIMAP similar genes for SSX4B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SSX4B: view

Variants for SSX4B Gene

Sequence variations from dbSNP and Humsavar for SSX4B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1062289 -- 48,402,185(-) ATGCG(A/T)CCTGG utr-variant-3-prime
rs6609732 -- 48,402,187(+) AGGTC(A/G)CATGG utr-variant-3-prime
rs6609733 -- 48,402,195(+) TGGCA(A/G)TGGAG utr-variant-3-prime
rs6609743 -- 48,403,697(+) GTTTA(C/G)AGAGG intron-variant
rs6609744 -- 48,408,242(+) TTTGA(C/G)ATTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSX4B Gene

Variant ID Type Subtype PubMed ID
esv25781 CNV Gain 19812545
esv32909 CNV Gain+Loss 17666407
esv2671998 CNV Deletion 23128226
nsv7441 OTHER Inversion 18451855

Relevant External Links for SSX4B Gene

HapMap Linkage Disequilibrium report
SSX4B

Disorders for SSX4B Gene

(1) MalaCards Diseases for SSX4B Gene

Search for SSX4B Gene in MalaCards »

(1) University of Copenhagen DISEASES for SSX4B Gene

genes like me logo Genes that share disorders with SSX4B: view

No data available for UniProtKB/Swiss-Prot for SSX4B Gene

Publications for SSX4B Gene

  1. SSX: a multigene family with several members transcribed in normal testis and human cancer. (PMID: 9378559) Gure A.O. … Chen Y.-T. (Int. J. Cancer 1997) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. CD4+ T cell responses to SSX-4 in melanoma patients. (PMID: 15814740) Ayyoub M. … Valmori D. (J. Immunol. 2005) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for SSX4B Gene

Sources for SSX4B Gene

Back to Top

Content