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Aliases for SSX4 Gene

Aliases for SSX4 Gene

  • Synovial Sarcoma, X Breakpoint 4 2 3
  • Cancer/Testis Antigen 5.4 3 4
  • CT5.4 3 4
  • SSX4 SSX4B 4
  • SSX4A 4

External Ids for SSX4 Gene

Previous GeneCards Identifiers for SSX4 Gene

  • GC0XM047064
  • GC0XM046522
  • GC0XP047069
  • GC0XP047288
  • GC0XM048017
  • GC0XP048127
  • GC0XP048242

Summaries for SSX4 Gene

Entrez Gene Summary for SSX4 Gene

  • The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4, represents the more telomeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SSX4 Gene

SSX4 (Synovial Sarcoma, X Breakpoint 4) is a Protein Coding gene. Diseases associated with SSX4 include sarcoma, synovial and sarcoma. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is SSX4B.

UniProtKB/Swiss-Prot for SSX4 Gene

  • Could act as a modulator of transcription

Gene Wiki entry for SSX4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSX4 Gene

Genomics for SSX4 Gene

Regulatory Elements for SSX4 Gene

Genomic Location for SSX4 Gene

48,383,516 bp from pter
48,393,347 bp from pter
9,832 bases
Plus strand

Genomic View for SSX4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSX4 Gene

Proteins for SSX4 Gene

  • Protein details for SSX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein SSX4
    Protein Accession:
    Secondary Accessions:
    • A8MYD4
    • B2RPE3
    • Q3SYD4
    • Q5JQZ0
    • Q9UJU9

    Protein attributes for SSX4 Gene

    188 amino acids
    Molecular mass:
    21858 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI03865.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence={ECO:0000305};

    Alternative splice isoforms for SSX4 Gene


neXtProt entry for SSX4 Gene

Proteomics data for SSX4 Gene at MOPED

Post-translational modifications for SSX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SSX4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SSX4 Gene

Domains & Families for SSX4 Gene

Protein Domains for SSX4 Gene

Suggested Antigen Peptide Sequences for SSX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB-related domain.
  • Belongs to the SSX family.
  • Contains 1 KRAB-related domain.
  • Belongs to the SSX family.
genes like me logo Genes that share domains with SSX4: view

No data available for Gene Families for SSX4 Gene

Function for SSX4 Gene

Molecular function for SSX4 Gene

GENATLAS Biochemistry:
protein SSX4 with homology to Kruppel associated box,KRAB,not implicated in t(X;18) synovial sarcoma
UniProtKB/Swiss-Prot Function:
Could act as a modulator of transcription

Gene Ontology (GO) - Molecular Function for SSX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003714 transcription corepressor activity IBA --
genes like me logo Genes that share ontologies with SSX4: view

Phenotypes for SSX4 Gene

GenomeRNAi human phenotypes for SSX4:
genes like me logo Genes that share phenotypes with SSX4: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSX4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SSX4 Gene

Localization for SSX4 Gene

Subcellular locations from

Jensen Localization Image for SSX4 Gene COMPARTMENTS Subcellular localization image for SSX4 gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for SSX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with SSX4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SSX4 Gene

Pathways & Interactions for SSX4 Gene

SuperPathways for SSX4 Gene

No Data Available

Interacting Proteins for SSX4 Gene

Selected Interacting proteins: O60224-SSX4_HUMAN for SSX4 Gene via I2D MINT

Gene Ontology (GO) - Biological Process for SSX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:1903507 negative regulation of nucleic acid-templated transcription IBA --
genes like me logo Genes that share ontologies with SSX4: view

No data available for Pathways by source and SIGNOR curated interactions for SSX4 Gene

Drugs & Compounds for SSX4 Gene

No Compound Related Data Available

Transcripts for SSX4 Gene

mRNA/cDNA for SSX4 Gene

(2) REFSEQ mRNAs :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSX4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSX4 Gene

No ASD Table

Relevant External Links for SSX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SSX4 Gene

mRNA expression in normal human tissues for SSX4 Gene

mRNA differential expression in normal tissues according to GTEx for SSX4 Gene

This gene is overexpressed in Testis (x53.0).
genes like me logo Genes that share expression patterns with SSX4: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SSX4 Gene

Orthologs for SSX4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SSX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SSX5 35
  • 63.54 (n)
  • 41.99 (a)
(Canis familiaris)
Mammalia LOC612524 35
  • 69 (n)
  • 51.61 (a)
(Mus musculus)
Mammalia Ssxb2 35
  • 66.29 (n)
  • 56.18 (a)
Species with no ortholog for SSX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SSX4 Gene

Gene Tree for SSX4 (if available)
Gene Tree for SSX4 (if available)

Paralogs for SSX4 Gene

Paralogs for SSX4 Gene

(13) SIMAP similar genes for SSX4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SSX4: view

Variants for SSX4 Gene

Sequence variations from dbSNP and Humsavar for SSX4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2005134 -- 48,388,950(-) AATGT(A/G)AAAAC intron-variant
rs2977592 -- 48,383,397(+) GCTTC(C/G)CTTGT upstream-variant-2KB
rs2977593 -- 48,381,844(-) GCCTC(A/G)GCCTC upstream-variant-2KB
rs3125187 -- 48,382,232(+) GGAGG(C/T)GGGAG upstream-variant-2KB
rs6609727 -- 48,382,096(+) cgagg(A/C)tgagg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SSX4 Gene

Variant ID Type Subtype PubMed ID
esv25781 CNV Gain 19812545
esv32909 CNV Gain+Loss 17666407
esv2671998 CNV Deletion 23128226
nsv7441 OTHER Inversion 18451855

Relevant External Links for SSX4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SSX4 Gene

Disorders for SSX4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SSX4 Gene - From: NovoSeek and GeneCards

Disorder Aliases PubMed IDs
sarcoma, synovial
  • synovial sarcoma
  • tumor of soft tissue and skeleton
- elite association
Search SSX4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SSX4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SSX4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSX4 Gene

Publications for SSX4 Gene

  1. Histone deacetylase inhibitors reverse SS18-SSX-mediated polycomb silencing of the tumor suppressor early growth response 1 in synovial sarcoma. (PMID: 18519690) Lubieniecka J.M. … Nielsen T.O. (Cancer Res. 2008) 23 67
  2. Evaluation of genetic stability of the SYT gene rearrangement by break-apart FISH in primary and xenotransplanted synovial sarcomas. (PMID: 17175375) Subramaniam M.M. … Llombart-Bosch A. (Cancer Genet. Cytogenet. 2007) 23 67
  3. Cancer-testis genes are coordinately expressed and are markers of poor outcome in non-small cell lung cancer. (PMID: 16299236) Gure A.O. … Altorki N.K. (Clin. Cancer Res. 2005) 23 67
  4. SSX expression in gynecological cancers and antibody response in patients. (PMID: 15603546) Hasegawa K. … Nakayama E. (Cancer Immun. 2004) 23 67
  5. The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PMID: 12007189) de Bruijn D.R.H. … van Kessel A.G. (Genes Chromosomes Cancer 2002) 23 67

Products for SSX4 Gene

Sources for SSX4 Gene

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