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Aliases for SSX4 Gene

Aliases for SSX4 Gene

  • SSX Family Member 4 2 3 5
  • Synovial Sarcoma, X Breakpoint 4 2 3
  • Cancer/Testis Antigen 5.4 3 4
  • CT5.4 3 4
  • Protein SSX4 3
  • SSX4 SSX4B 4
  • SSX4A 4

External Ids for SSX4 Gene

Previous GeneCards Identifiers for SSX4 Gene

  • GC0XM047064
  • GC0XM046522
  • GC0XP047069
  • GC0XP047288
  • GC0XM048017
  • GC0XP048127
  • GC0XP048242

Summaries for SSX4 Gene

Entrez Gene Summary for SSX4 Gene

  • The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4, represents the more telomeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

CIViC summary for SSX4 Gene

GeneCards Summary for SSX4 Gene

SSX4 (SSX Family Member 4) is a Protein Coding gene. Diseases associated with SSX4 include Sarcoma and Sarcoma, Synovial. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is SSX4B.

UniProtKB/Swiss-Prot for SSX4 Gene

  • Could act as a modulator of transcription.

Gene Wiki entry for SSX4 Gene

Additional gene information for SSX4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSX4 Gene

Genomics for SSX4 Gene

GeneHancer (GH) Regulatory Elements for SSX4 Gene

Promoters and enhancers for SSX4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI048383 Promoter 0.5 EPDnew 550.8 +0.0 4 0.1 SSX4 LOC101060049 SSX4B
GH0XI048411 Promoter 0.5 EPDnew 0.3 +28.4 28391 0.1 LOC791095 SSX4B SSX4
GH0XI048412 Promoter 0.5 EPDnew 0.3 +27.9 27909 0.1 LOC791095 SSX4B SSX4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SSX4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SSX4 gene promoter:

Genomic Locations for SSX4 Gene

Genomic Locations for SSX4 Gene
9,832 bases
Plus strand

Genomic View for SSX4 Gene

Genes around SSX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSX4 Gene

Proteins for SSX4 Gene

  • Protein details for SSX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein SSX4
    Protein Accession:
    Secondary Accessions:
    • A8MYD4
    • B2RPE3
    • Q3SYD4
    • Q5JQZ0
    • Q9UJU9

    Protein attributes for SSX4 Gene

    188 amino acids
    Molecular mass:
    21858 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI03865.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence={ECO:0000305};

    Alternative splice isoforms for SSX4 Gene


neXtProt entry for SSX4 Gene

Post-translational modifications for SSX4 Gene

No Post-translational modifications

Other Protein References for SSX4 Gene

No data available for DME Specific Peptides for SSX4 Gene

Domains & Families for SSX4 Gene

Gene Families for SSX4 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for SSX4 Gene

Suggested Antigen Peptide Sequences for SSX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SSX family.
  • Belongs to the SSX family.
genes like me logo Genes that share domains with SSX4: view

Function for SSX4 Gene

Molecular function for SSX4 Gene

GENATLAS Biochemistry:
protein SSX4 with homology to Kruppel associated box,KRAB,not implicated in t(X;18) synovial sarcoma
UniProtKB/Swiss-Prot Function:
Could act as a modulator of transcription.

Gene Ontology (GO) - Molecular Function for SSX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003714 transcription corepressor activity IBA --
genes like me logo Genes that share ontologies with SSX4: view
genes like me logo Genes that share phenotypes with SSX4: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SSX4 Gene

Localization for SSX4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSX4 gene
Compartment Confidence
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SSX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SSX4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SSX4 Gene

Pathways & Interactions for SSX4 Gene

No Data Available

Interacting Proteins for SSX4 Gene

Selected Interacting proteins: O60224-SSX4_HUMAN for SSX4 Gene via IID

Gene Ontology (GO) - Biological Process for SSX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:1903507 negative regulation of nucleic acid-templated transcription IBA --
genes like me logo Genes that share ontologies with SSX4: view

No data available for Pathways by source and SIGNOR curated interactions for SSX4 Gene

Drugs & Compounds for SSX4 Gene

No Compound Related Data Available

Transcripts for SSX4 Gene

mRNA/cDNA for SSX4 Gene

(3) REFSEQ mRNAs :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSX4 Gene

No ASD Table

Relevant External Links for SSX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SSX4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSX4 Gene

mRNA differential expression in normal tissues according to GTEx for SSX4 Gene

This gene is overexpressed in Testis (x53.0).

NURSA nuclear receptor signaling pathways regulating expression of SSX4 Gene:

genes like me logo Genes that share expression patterns with SSX4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSX4 Gene

Orthologs for SSX4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SSX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC612524 33
  • 69 (n)
(Mus musculus)
Mammalia Ssxb2 33
  • 66.29 (n)
(Bos Taurus)
Mammalia SSX5 33
  • 63.54 (n)
Species where no ortholog for SSX4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SSX4 Gene

Gene Tree for SSX4 (if available)
Gene Tree for SSX4 (if available)

Paralogs for SSX4 Gene

Paralogs for SSX4 Gene

(13) SIMAP similar genes for SSX4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SSX4: view

Variants for SSX4 Gene

Sequence variations from dbSNP and Humsavar for SSX4 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1062275 -- 48,393,018(+) C/T 3_prime_UTR_variant
rs111557609 -- 48,388,688(+) A/T intron_variant
rs112461287 -- 48,389,191(+) A/G intron_variant
rs113446172 -- 48,383,679(+) T/C 5_prime_UTR_variant, intron_variant
rs113925712 -- 48,391,923(+) T/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for SSX4 Gene

Variant ID Type Subtype PubMed ID
esv25781 CNV gain 19812545
esv2671998 CNV deletion 23128226
esv32909 CNV gain+loss 17666407
esv3573944 CNV loss 25503493
esv3576858 CNV gain 25503493
nsv1141675 CNV duplication 24896259
nsv1153914 CNV duplication 26484159
nsv7441 OTHER inversion 18451855

Additional Variant Information for SSX4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SSX4 Gene

Disorders for SSX4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SSX4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • connective and soft tissue neoplasm
sarcoma, synovial
  • synovial sarcoma
synovium cancer
  • malignant tumor of synovium
- elite association - COSMIC cancer census association via MalaCards
Search SSX4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SSX4

genes like me logo Genes that share disorders with SSX4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSX4 Gene

Publications for SSX4 Gene

  1. SSX: a multigene family with several members transcribed in normal testis and human cancer. (PMID: 9378559) Gure AO … Chen YT (International journal of cancer 1997) 3 4 22 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PMID: 12007189) de Bruijn DR … van Kessel AG (Genes, chromosomes & cancer 2002) 3 22 58
  5. Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression. (PMID: 11368913) Brodin B … Larsson O (Gene 2001) 3 22 58

Products for SSX4 Gene

Sources for SSX4 Gene

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