Aliases for SSX4 Gene
External Ids for SSX4 Gene
Previous GeneCards Identifiers for SSX4 Gene
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4, represents the more telomeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SSX4 Gene
SSX4 (Synovial Sarcoma, X Breakpoint 4) is a Protein Coding gene. Diseases associated with SSX4 include ewing sarcoma and sarcoma. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is SSX3.
UniProtKB/Swiss-Prot for SSX4 Gene
Could act as a modulator of transcription.