SSX3 Gene
protein-coding GIFtS: 49
GCID: GC0XM048205
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|
synovial sarcoma, X breakpoint 3
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Aliases
for SSX3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Synovial Sarcoma, X Breakpoint 31 2 | | CT5.31 2 3 | | Cancer/Testis Antigen 5.32 3 | | Protein SSX32 |
Export aliases for SSX3 gene to outside databasesPrevious GC identifers: GC0XM047008 GC0XM046466 GC0XM047200 GC0XM047251 GC0XM047962 GC0XM048090 GC0XM045914 |
Summaries
for SSX3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SSX3:
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. Theseproteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral andcellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-basedimmunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found inall synovial sarcomas. This gene appears not to be involved in this type of chromosome translocation. Two transcriptvariants encoding distinct isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SSX3_HUMAN, Q99909Function: Could act as a modulator of transcription
|
Genomic Views
for SSX3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_079573.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SSX3 gene promoter:
C/EBPbeta HNF-1A C/EBPalpha POU2F1 HNF-1 POU2F1a POU2F1b Sox9 POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for SSX3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSX3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23SSX3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM048205: view genomic region
(about GC identifiers)
Start:
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48,205,863 bp from pter |
End:
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48,216,142 bp from pter |
Size:
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10,280 bases |
Orientation:
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minus strand |
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Proteins
for SSX3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SSX3_HUMAN, Q99909 (See
protein sequence)Recommended Name: Protein SSX3 Size: 188 amino acids; 21697 Da
Subunit: Interacts with SSX2IP
Secondary accessions: O60223 Q5JQZ3 Q9BRW7Alternative splicing: 2 isoforms: Q99909-1 Q99909-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SSX3: NX_Q99909
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q99909
SSX3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_066294.1 NP_783642.1
ENSEMBL proteins: ENSP00000298396 ENSP00000366092 ENSP00000366090
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
SSX3 for ontologies About GeneDecksing
SSX3 Antibody Products:
Assay Products for SSX3: |
Protein
Domains /
Families
for SSX3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SSX3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q99909ProtoNet protein and cluster: Q99909 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: SSX3_HUMAN, Q99909Similarity: Belongs to the SSX familySimilarity: Contains 1 KRAB-related domain |
Function
for SSX3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SSX3_HUMAN, Q99909Function: Could act as a modulator of transcription Genatlas biochemistry entry for SSX3:protein SSX3 with homology to Kruppel associated box,KRAB,not implicated in t(X;18) synovial sarcoma
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSX3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSX3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for SSX3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSX3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- |
SSX3 for ontologies About GeneDecksing
|
Pathways & Interactions
for SSX3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SSX3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/7 Interacting proteins for SSX3 (Q999093 ENSP000002983964) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
SSX3 for ontologies About GeneDecksing
|
Drugs & Compounds
for SSX3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SSX3
Search CenterWatch for drugs/clinical trials and news about SSX3
|
Transcripts
for SSX3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SSX3 gene (2 alternative transcripts): NM_021014.2 NM_175711.1 Unigene Cluster for SSX3: Synovial sarcoma, X breakpoint 3 Hs.558445 [show with all ESTs]Unigene Representative Sequence: NM_0210143 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000298396(uc004djd.1) ENST00000376895 ENST00000376893(uc004dje.3 uc010nic.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSX3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSX3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SSX3 (NM_021014) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SSX3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSX3 |
Additional cDNA sequence: AK310348.1 AK310513.1 BC005904.1 BC103862.1 S82471.1 U90840.1 3 DOTS entries: DT.100822740 DT.95157177 DT.121307474 10 AceView cDNA sequences: BC005904 NM_175711 NM_021014 S82471 AA609599 U90840 BF184274 BX283846 BU189304 BG722220
GeneLoc Exon Structure
|
Expression
for SSX3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SSX3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SSX3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SSX3
SOURCE GeneReport for Unigene cluster: Hs.558445
SABiosciences Custom PCR Arrays for SSX3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SSX3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SSX3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSX3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSX3 |
Orthologs
for SSX3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for SSX3 (if available)
TreeFam Gene Tree for SSX3 (if available) |
Paralogs
for SSX3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SSX3 gene
- SSX2B2 SSX22 SSX62 SSX42 SSX72 SSX12 SSX52 SSX92
- SSX4B2
17 SIMAP similar genes for SSX3 using alignment to 2 protein entries: SSX3_HUMAN (see all proteins):SSX2B SS18/SSX2 fusion SSX10 SSX9 SSX6 SSX5
SSX7 SSX2 SSX4B SSX1 SSX4 SSX8
SSX11 SYT-SSX2 SS18/SSX1 fusion SYT-SSX1 SSX-HSTT
SSX3 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for SSX3
PGOHUM00000241317 PGOHUM00000241778
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Genomic Variants
for SSX3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SSX3 (48205863 - 48216142 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for SSX3
5 CNVs: 96641 83494 67975 67974 7789
Locus Specific Mutation Databases (LSDB): SSX3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSX3 |
|
Disorders
/ Diseases
for SSX3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SSX3 for disorders About GeneDecksing
OMIM gene information: 300325
OMIM disorders: --
3  diseases for SSX3: About MalaCardssynovial sarcoma sarcoma melanoma
1 disease from the University of Copenhagen DISEASES database for SSX3:Synovial sarcoma 2 Novoseek disease relationships for SSX3 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| sarcoma synovial |
86.1 |
2 |
8697803 (2) |
| melanoma |
43 |
1 |
9378559 (1) |
Export disorders for SSX3 gene to outside databases
|
Publications
for SSX3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SSX3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SSX3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel Kruppel-associated box containing the SSX gene (SSX3) on the human X chromosome is not implicated in t(X;18)-positive synovial sarcomas. (PubMed id 8697803)1, 2, 3, 9 de Leeuw B.... Geurts van Kessel A. (1996)
- SSX: a multigene family with several members transcribed in normal testis and human cancer. (PubMed id 9378559)1, 2, 3, 9 Gure A.O....Chen Y.T. (1997)
- The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PubMed id 12007189)1, 2, 9 de Bruijn D.R.H....van Kessel A.G. (2002)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- The SSX gene family: characterization of 9 complete genes. (PubMed id 12216073)1 Gure A.O.... Chen Y.-T. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines. (PubMed id 10749136)9 dos Santos N.R.... Geurts van Kessel A. (2000)
- Detection of the SYT-SSX fusion transcripts in formaldehyde-fixed, paraffin-embedded tissue: a reverse transcription polymerase chain reaction amplification assay useful in the diagnosis of synovial sarcoma. (PubMed id 9688183)9 Lasota J....Miettinen M. (1998)
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External Searches for SSX3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SSX3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SSX3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SSX3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SSX3 gene:
Search GeneIP for patents involving SSX3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SSX3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SSX3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SSX3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SSX3 | | | OriGene Protein Over-expression Lysate for SSX3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SSX3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSX3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSX3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SSX3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SSX3 | | OriGene Custom Protein Services for SSX3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SSX3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSX3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSX3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSX3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSX3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSX3 |
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| | | | Search Tocris compounds for SSX3 |
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 | | | SSX3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for SSX3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSX3 |
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