Aliases for SSX3 Gene
Aliases for SSX3 Gene
External Ids for SSX3 Gene
- HGNC: 11337
- Entrez Gene: 10214
- Ensembl: ENSG00000165584
- OMIM: 300325
- UniProtKB: Q99909
Previous GeneCards Identifiers for SSX3 Gene
- GC0XM047008
- GC0XM046466
- GC0XM047200
- GC0XM047251
- GC0XM047962
- GC0XM048090
- GC0XM048205
- GC0XM045914
Summaries for SSX3 Gene
-
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. While some of the related SSX genes are involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas, this gene does not appear to be involved in such translocations. [provided by RefSeq, Jul 2013]
GeneCards Summary for SSX3 Gene
SSX3 (SSX Family Member 3) is a Protein Coding gene. Diseases associated with SSX3 include Sarcoma, Synovial and Sarcoma. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is SSX5.
UniProtKB/Swiss-Prot for SSX3 Gene
-
Could act as a modulator of transcription.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSX3 Gene
Genomics for SSX3 Gene
GeneHancer (GH) Regulatory Elements for SSX3 Gene
Promoters and enhancers for SSX3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH0XI048356 | Promoter | 0.9 | EPDnew | 550.8 | +0.0 | 32 | 0.1 | PKNOX1 L3MBTL2 NRF1 ASH1L ZBTB40 GABPA E2F1 E2F8 GABPB1 | LOC791093 SSX3 FTSJ1 ENSG00000270747 | |
| GH0XI048789 | Enhancer | 1 | FANTOM5 ENCODE dbSUPER | 1.6 | -433.0 | -433012 | 0.5 | STAT1 ZNF740 NFXL1 EP300 NCOR1 MTA1 POLR2A GABPB1 VEZF1 SPI1 | GATA1 ENSG00000204620 SLC38A5 MAGIX SSX3 HDAC6 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SSX3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for SSX3 Gene
Genomic Locations for SSX3 Gene
- chrX:48,346,428-48,356,753
- (GRCh38/hg38)
- Size:
- 10,326 bases
- Orientation:
- Minus strand
- chrX:48,205,863-48,216,142
- (GRCh37/hg19)
Genomic View for SSX3 Gene
Genes around SSX3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp11.23 by Ensembl
- Xp11.23 by Entrez Gene
- Xp11.23 by HGNC
SSX3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SSX3 Gene
Proteins for SSX3 Gene
-
Protein details for SSX3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99909-SSX3_HUMAN
- Recommended name:
- Protein SSX3
- Protein Accession:
- Q99909
- O60223
- Q5JQZ3
- Q9BRW7
Protein attributes for SSX3 Gene
- Size:
- 188 amino acids
- Molecular mass:
- 21697 Da
- Quaternary structure:
-
- Interacts with SSX2IP.
Protein Expression for SSX3 Gene
Post-translational modifications for SSX3 Gene
No Post-translational modifications
Other Protein References for SSX3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
Abcam antibodies for SSX3
- Invitrogen Antibodies for SSX3
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-
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Protein Products
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- antibodies-online: Search results for 5 available SSX3 Proteins ranked by validation data
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-
Quality Products:
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-
Abcam proteins for SSX3
Assay Products
- antibodies-online: Search results for available SSX3 related products ranked by validation data
No data available for DME Specific Peptides for SSX3 Gene
Domains & Families for SSX3 Gene
Gene Families for SSX3 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for SSX3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SSX3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q99909- Family:
-
- Belongs to the SSX family.
Function for SSX3 Gene
Molecular function for SSX3 Gene
- GENATLAS Biochemistry:
- protein SSX3 with homology to Kruppel associated box,KRAB,not implicated in t(X;18) synovial sarcoma
- UniProtKB/Swiss-Prot Function:
- Could act as a modulator of transcription.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003714 | transcription corepressor activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for SSX3 Gene
Animal Model Products
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-
-
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-
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CRISPR Products
-
OriGene CRISPR knockouts for SSX3
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SSX3
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miRNA Products
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Inhibitory RNA Products
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-
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Clone Products
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- VectorBuilder custom plasmid, inducible vectors for SSX3
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available SSX3 gene related products
- orf clones - Search results for available SSX3 gene related products
- Applied Biological Materials Clones for SSX3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SSX3
-
ViGene Biosciences adenoviral particle packaged cDNA for SSX3 gene
-
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-
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SSX3 Gene
Localization for SSX3 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 3 |
| extracellular | 1 |
- Nucleoli (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for SSX3 Gene
Pathways & Interactions for SSX3 Gene
No Data Available
Interacting Proteins for SSX3 Gene
Selected Interacting proteins:
Q99909-SSX3_HUMAN
ENSP00000298396
for SSX3 Gene via
IID
UniProtKB
STRING
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:1903507 | negative regulation of nucleic acid-templated transcription | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for SSX3 Gene
Transcripts for SSX3 Gene
mRNA/cDNA for SSX3 Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (10) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SSX3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SSX3
- genomics-online: gRNA clones - Search results for available SSX3 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SSX3
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miRNA Products
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Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SSX3
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- genomics-online: shRNA clones - Search results for available SSX3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SSX3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SSX3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SSX3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available SSX3 gene related products
- orf clones - Search results for available SSX3 gene related products
- Applied Biological Materials Clones for SSX3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for SSX3 Gene
mRNA differential expression in normal tissues according to GTEx for SSX3 Gene
This gene is overexpressed in Testis (x51.9).
This gene is overexpressed in Ovary (35.5) and Testis (33.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SSX3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SSX3 Gene:
SSX3SOURCE GeneReport for Unigene cluster for SSX3 Gene:
Hs.558445Evidence on tissue expression from TISSUES for SSX3 Gene
- Bone marrow(4)
Primer Products
-
OriGene qPCR primer pairs and template standards for SSX3
-
OriGene qPCR primer pairs for SSX3
- genomics-online: primer clones - Search results for available SSX3 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSX3 Gene
Orthologs for SSX3 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SSX3 34 |
|
OneToOne | |
| LOC737502 33 |
|
||||
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Ssxa1 34 |
|
ManyToMany | |
| Gm21876 34 |
|
ManyToMany | |||
| Gm5751 34 |
|
ManyToMany | |||
| Ssxb5 34 |
|
ManyToMany | |||
| Ssxb1 34 |
|
ManyToMany | |||
| Ssxb10 34 |
|
ManyToMany | |||
| Ssxb8 34 |
|
ManyToMany | |||
| Ssxb3 34 |
|
ManyToMany | |||
| Gm14459 34 |
|
ManyToMany | |||
| Gm6592 34 |
|
ManyToMany | |||
| Ssx9 34 |
|
ManyToMany | |||
| Ssxb9 34 |
|
ManyToMany | |||
| Ssxb2 34 |
|
ManyToMany | |||
| Ssxb6 34 |
|
ManyToMany | |||
| cow (Bos Taurus) |
Mammalia | SSX5 34 |
|
OneToMany |
- Species where no ortholog for SSX3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for SSX3 Gene
(16) SIMAP similar genes for SSX3 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for SSX3 Gene
Variants for SSX3 Gene
| SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs112625608 | -- | 48,357,307(-) | G/A | upstream_transcript_variant | |
| rs112850154 | -- | 48,357,379(-) | C/T | upstream_transcript_variant | |
| rs11323384 | -- | 48,355,580(-) | A/ | intron_variant | |
| rs113398904 | -- | 48,353,846(-) | A/G | intron_variant | |
| rs113403735 | -- | 48,354,694(-) | T/C | coding_sequence_variant, missense_variant |
Residual Variation Intolerance Score:
66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.41;
9.03% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SSX3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSX3 Gene
Disorders for SSX3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| sarcoma, synovial |
|
|
| sarcoma |
|
|
| synovium cancer |
|
|
Search SSX3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SSX3
No data available for UniProtKB/Swiss-Prot and Genatlas for SSX3 Gene
Publications for SSX3 Gene
- SSX: a multigene family with several members transcribed in normal testis and human cancer. (PMID: 9378559) Gure AO … Chen YT (International journal of cancer 1997) 2 3 4 22 58
- A novel Krüppel-associated box containing the SSX gene (SSX3) on the human X chromosome is not implicated in t(X;18)-positive synovial sarcomas. (PMID: 8697803) de Leeuw B … Geurts van Kessel A (Cytogenetics and cell genetics 1996) 2 3 4 22 58
- The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PMID: 12007189) de Bruijn DR … van Kessel AG (Genes, chromosomes & cancer 2002) 3 4 22 58
- The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for SSX3 Gene
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- Invitrogen Antibodies for SSX3
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SSX3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 29 available SSX3 Antibodies ranked by validation data
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- antibodies-online: Search results for available SSX3 related products ranked by validation data
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- Quality Products:
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- Search ViGene Biosciences for SSX3
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- genomics-online: cdna clones - Search results for available SSX3 gene related products
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Sources for SSX3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew