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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SSX3 Gene

protein-coding GIFtS: 49
GCID: GC0XM048205

Synovial Sarcoma, X Breakpoint 3

3 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Synovial Sarcoma, X Breakpoint 3¹ ²
Cancer/Testis Antigen 5.3² ³
CT5.3² ³
Kruppel-Associated Box Containing Gene Product SSX3²
Protein SSX3²

External Ids:	HGNC: 11337¹	Entrez Gene: 10214²	Ensembl: ENSG00000165584⁷	OMIM: 300325⁵	UniProtKB: Q99909³

Export aliases for SSX3 gene to outside databases

Previous GC identifers: GC0XM047008 GC0XM046466 GC0XM047200 GC0XM047251 GC0XM047962 GC0XM048090 GC0XM045914

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SSX3 Gene:

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins.

These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral

and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based

immunotherapy. While some of the related SSX genes are involved in t(X;18)(p11.2;q11.2) translocations that are

characteristically found in all synovial sarcomas, this gene does not appear to be involved in such

translocations. (provided by RefSeq, Jul 2013)

GeneCards Summary for SSX3 Gene:

SSX3 (synovial sarcoma, X breakpoint 3) is a protein-coding gene. Diseases associated with SSX3 include synovial sarcoma, and sarcoma. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is SSX2B.

UniProtKB/Swiss-Prot: SSX3_HUMAN, Q99909

Function: Could act as a modulator of transcription

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NT_079573.4 NC_018934.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SSX3 gene promoter:
C/EBPbeta HNF-1A C/EBPalpha POU2F1 HNF-1 POU2F1a POU2F1b Sox9 POU2F1c
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SSX3 promoter sequence

Search SABiosciences Chromatin IP Primers for SSX3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSX3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23

SSX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSX3 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM048205: view genomic region (about GC identifiers)

Start:	48,205,863 bp from pter	End:	48,216,142 bp from pter
Size:	10,280 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SSX3_HUMAN, Q99909 (See protein sequence)

Recommended Name: Protein SSX3

Size: 188 amino acids; 21697 Da

Subunit: Interacts with SSX2IP

Secondary accessions: O60223 Q5JQZ3 Q9BRW7

Alternative splicing: 2 isoforms: Q99909-1 Q99909-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SSX3: NX_Q99909

Explore proteomics data for SSX3 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q99909

SSX3 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_066294.1

ENSEMBL proteins:

ENSP00000298396 ENSP00000366092 ENSP00000366090

Human Recombinant Protein Products for SSX3:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins for SSX3 OriGene Protein Over-expression Lysate for SSX3 OriGene MassSpec for SSX3 OriGene Custom Protein Services for SSX3
	GenScript Custom Purified and Recombinant Proteins Services for SSX3
	Novus Biologicals SSX3 Proteins Novus Biologicals SSX3 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for SSX3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

SSX3 for ontologies About GeneDecksing

SSX3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	GenScript Custom Superior Antibodies Services for SSX3
	Novus Biologicals SSX3 Antibodies
	Abcam antibodies for SSX3
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	Search ThermoFisher Antibodies for SSX3
	LSBio Antibodies in human, mouse, rat for SSX3

Assay Products for SSX3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for SSX3
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SSX3
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for SSX3 Cloud-Clone Corp. CLIAs for SSX3

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

3 InterPro protein domains:

IPR003655 Krueppel-associated_box-rel

IPR019041 SSXRD_motif

IPR001909 Krueppel-associated_box

Graphical View of Domain Structure for InterPro Entry Q99909

ProtoNet protein and cluster: Q99909

1 Blocks protein domain: IPB001909 KRAB box

UniProtKB/Swiss-Prot: SSX3_HUMAN, Q99909

Similarity: Belongs to the SSX family

Similarity: Contains 1 KRAB-related domain

SSX3 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SSX3_HUMAN, Q99909

Function: Could act as a modulator of transcription

Genatlas biochemistry entry for SSX3:

protein SSX3 with homology to Kruppel associated box,KRAB,not implicated in t(X;18) synovial sarcoma

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--

SSX3 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for SSX3

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SSX3

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SSX3

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SSX3

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSX3
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate SSX3:
		hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p
		SwitchGear 3'UTR luciferase reporter plasmid: SSX3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for SSX3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSX3

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SSX3
			Sirion Biotech Customized adenovirus for overexpression of SSX3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for SSX3 (see all 10) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SSX3 (NM_021014)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSX3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSX3
		Sirion Biotech Customized lentivirus for stable overexpression of SSX3 Customized lentivirus expression plasmids for stable overexpression of SSX3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SSX3
		Search LifeMap BioReagents cell lines for SSX3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSX3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SSX3

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/7 Interacting proteins for SSX3 (Q99909³ ENSP00000298396⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ZBTB25	P24278³, ENSP00000261683⁴	I2D: score=1 STRING: ENSP00000261683
SSX2IP	Q9Y2D8³, ENSP00000340279⁴	I2D: score=1 STRING: ENSP00000340279
DDIT3	P35638³, ENSP00000340671⁴	I2D: score=1 STRING: ENSP00000340671
PCBD2	Q9H0N5³, ENSP00000254908⁴	I2D: score=1 STRING: ENSP00000254908
ZBTB3	Q9H5J0³, ENSP00000378286⁴	I2D: score=1 STRING: ENSP00000378286

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

SSX3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SSX3

Search CenterWatch for drugs/clinical trials and news about SSX3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SSX3 gene (2 alternative transcripts):

NM_021014.3 NM_175711.1

Unigene Cluster for SSX3:

Synovial sarcoma, X breakpoint 3

Hs.558445 [show with all ESTs]

Unigene Representative Sequence: NM_021014

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000298396(uc004djd.1) ENST00000376895 ENST00000376893(uc004dje.3 uc010nic.3)

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSX3
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate SSX3:
		hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p
		SwitchGear 3'UTR luciferase reporter plasmid: SSX3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for SSX3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSX3

Clone Products:		OriGene clones in human, mouse for SSX3 (see all 10) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SSX3 (NM_021014)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSX3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSX3
		Sirion Biotech Customized lentivirus for stable overexpression of SSX3 Customized lentivirus expression plasmids for stable overexpression of SSX3

Primer Products:		OriGene qPCR primer pairs and template standards for SSX3 OriGene qSTAR qPCR primer pairs in human, mouse for SSX3
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat SSX3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSX3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSX3

Additional mRNA sequence:

AK310348.1 AK310513.1 BC005904.1 BC103862.1 S82471.1 U90840.1

3 DOTS entries:

DT.100822740 DT.95157177 DT.121307474

10 AceView cDNA sequences:

BC005904 NM_175711 NM_021014 S82471 U90840 AA609599 BF184274 BX283846

BU189304 BG722220

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SSX3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

See SSX3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SSX3

SOURCE GeneReport for Unigene cluster: Hs.558445

SABiosciences Custom PCR Arrays for SSX3

Primer Products:		OriGene qPCR primer pairs and template standards for SSX3 OriGene qSTAR qPCR primer pairs in human, mouse for SSX3
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat SSX3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSX3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSX3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSX3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for SSX3 (if available)
TreeFam Gene Tree for SSX3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SSX3 gene

SSX2B² SSX2² SSX6² SSX4² SSX7² SSX1² SSX5² SSX9²

SSX4B²

17 SIMAP similar genes for SSX3 using alignment to 2 protein entries: SSX3_HUMAN (see all proteins):

SSX2B SS18/SSX2 fusion SSX10 SSX9 SSX6 SSX5

SSX7 SSX2 SSX4B SSX1 SSX4 SSX8

SSX11 SYT-SSX2 SS18/SSX1 fusion SYT-SSX1 SSX-HSTT

SSX3 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for SSX3
PGOHUM00000241317 PGOHUM00000241778

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183063219^1,2		--	48124949(+)	`AGGATC/TGCTTT`	1	--	ds500¹		0	--	--	--	--
rs189037398^1,2		--	48125063(+)	`CTCTGA/GAGGCT`	1	--	ds500¹		0	--	--	--	--
rs7889704^1,2	C,A	--	48125142(+)	`cagccA/Tggaca`	1	--	ds500¹		0	--	--	--	--
rs182754561^1,2		--	48125260(+)	`GATGTC/TGCTCC`	1	--	ds500¹		0	--	--	--	--
rs72619013^1,2	C	--	48125280(+)	`AACAGC/TGCTCA`	1	--	ds500¹		0	--	--	--	--
rs145506332^1,2	C	--	48125362(+)	`TTTCCC/TAAAGA`	1	--	ds500¹		0	--	--	--	--
rs12559241^1,2	C,H	--	48125463(+)	`GACTGA/CTACAG`	1	--	ut3¹ ese³		0	--	--	--	--
rs72172699^1,2	C	--	48125579(+)	`ACTTG-/GTGT GTGTCTGTGTG`	1	--	ut3¹		0	--	--	--	--
rs71822704^1,2	C	--	48125586(+)	`GTGTG-/TCTGTGT`	1	--	ut3¹		0	--	--	--	--
rs3125215^1,2	C,H	--	48125587(+)	`TGTGTG/CTGTGT`	1	--	ut3¹ ese³		2		NA	4

HapMap Linkage Disequilibrium report for SSX3 (48205863 - 48216142 bp)

Structural Variations
Database of Genomic Variants (DGV) 6 variations for SSX3: About this table

Variant ID	Type	Subtype	PubMed ID
esv2671998	CNV	Deletion	23128226
nsv508769	CNV	Insertion	20534489
esv25781	CNV	Gain	19812545
nsv523595	CNV	Gain	19592680
esv32909	CNV	Gain+Loss	17666407
nsv7441	OTHER	Inversion	18451855

Locus Specific Mutation Databases (LSDB): SSX3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSX3

DNA2.0 Custom Variant and Variant Library Synthesis for SSX3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 300325 OMIM disorders: --

3 diseases for SSX3: About MalaCards

synovial sarcoma sarcoma melanoma

1 disease from the University of Copenhagen DISEASES database for SSX3:

Synovial sarcoma

SSX3 for disorders About GeneDecksing

2 Novoseek inferred disease relationships for SSX3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sarcoma synovial	86.1	2	8697803 (2)
melanoma	43	1	9378559 (1)

Export disorders for SSX3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SSX3 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with SSX3)

Utopia: connect your pdf to the dynamic
world of online information

A novel Kruppel-associated box containing the SSX gene (SSX3) on the human X chromosome is not implicated in t(X;18)-positive synovial sarcomas. (PubMed id 8697803)^{1, 2, 3, 9} de Leeuw B.... Geurts van Kessel A. (1996)
SSX: a multigene family with several members transcribed in normal testis and human cancer. (PubMed id 9378559)^{1, 2, 3, 9} Gure A.O....Chen Y.T. (1997)
The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PubMed id 12007189)^{1, 2, 9} de Bruijn D.R.H....van Kessel A.G. (2002)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines. (PubMed id 10749136)^{1, 9} dos Santos N.R.... Geurts van Kessel A. (2000)
An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)¹ Ravasi T....Hayashizaki Y. (2010)
A multigene predictor of metastatic outcome in early stage hormone receptor-negative and triple-negative breast cancer. (PubMed id 20946665)¹ Yau C....Benz C.C. (2010)
The SSX gene family: characterization of 9 complete genes. (PubMed id 12216073)¹ Gure A.O.... Chen Y.-T. (2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10214	HGNC: 11337	AceView: SSX3	Ensembl:ENSG00000165584	euGenes: HUgn10214
ECgene: SSX3	H-InvDB: SSX3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SSX3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SSX3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SSX3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SSX3 gene:
Search GeneIP for patents involving SSX3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for SSX3
	OriGene qPCR primer pairs and template standards for SSX3		OriGene Protein Over-expression Lysate for SSX3
	OriGene MassSpec something-or-other for SSX3		OriGene clones in human, mouse for SSX3
	OriGene qSTAR qPCR primer pairs in human, mouse for SSX3		OriGene Purified Protein for SSX3
	Browse OriGene ORF clones		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SSX3		OriGene Custom Protein Services for SSX3

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SSX3
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSX3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSX3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSX3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSX3
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSX3

	GenScript Custom Purified and Recombinant Proteins Services for SSX3		GenScript cDNA clones with any tag delivered in your preferred vector for SSX3
	GenScript Custom Assay Services for SSX3		GenScript Custom Superior Antibodies Services for SSX3
	GenScript Custom overexpressing Cell Line Services for SSX3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in SSX3 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SSX3 antibodies
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	SSX3 lysates

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Browse ProSpec Recombinant Proteins

	Proteins for SSX3
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Search LifeMap BioReagents cell lines for SSX3

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSX3

	SwitchGear 3'UTR luciferase reporter plasmids for SSX3
	SwitchGear Promoter luciferase reporter plasmids for SSX3

Search ThermoFisher Antibodies for SSX3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSX3

	inGenious Targeting Laboratory - Custom generated mouse model solutions for SSX3
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SSX3

Customized:

	lentivirus for stable overexpression of SSX3
	lentivirus expression plasmids for stable overexpression of SSX3
	adenovirus for overexpression of SSX3

LSBio Antibodies in human, mouse, rat for SSX3

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SSX3 gene at Home site.

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SSX3 Gene

Synovial Sarcoma, X Breakpoint 3

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SSX3 Gene

Synovial Sarcoma, X Breakpoint 3

Aliasesfor SSX3 gene

Summariesfor SSX3 gene

Genomic Viewsfor SSX3 gene

Proteinsfor SSX3 gene

Protein Domains /Familiesfor SSX3 gene

Functionfor SSX3 gene

Pathways & Interactionsfor SSX3 gene

Drugs & Compoundsfor SSX3 gene

Transcriptsfor SSX3 gene

Expression for SSX3 gene

Orthologsfor SSX3 gene

Paralogsfor SSX3 gene

Genomic Variantsfor SSX3 gene

Disorders / Diseasesfor SSX3 gene

Publicationsfor SSX3 gene

External Searches for SSX3 gene

Genome Databases showing SSX3 gene

Other Databases showing SSX3 gene

Specialized Databases showing SSX3 gene

Intellectual Propertyfor SSX3 gene

Productsfor SSX3 gene

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Aliases
for SSX3 gene

Summaries
for SSX3 gene

Genomic Views
for SSX3 gene

Proteins
for SSX3 gene

Protein Domains /
Families
for SSX3 gene

Function
for SSX3 gene

Pathways & Interactions
for SSX3 gene

Drugs & Compounds
for SSX3 gene

Transcripts
for SSX3 gene

Expression
for SSX3 gene

Orthologs
for SSX3 gene

Paralogs
for SSX3 gene

Genomic Variants
for SSX3 gene

Disorders / Diseases
for SSX3 gene

Publications
for SSX3 gene

Intellectual Property
for SSX3 gene

Products
for SSX3 gene