Aliases for SSX3 Gene
Aliases for SSX3 Gene
External Ids for SSX3 Gene
- HGNC: 11337
- Entrez Gene: 10214
- Ensembl: ENSG00000165584
- OMIM: 300325
- UniProtKB: Q99909
Previous GeneCards Identifiers for SSX3 Gene
- GC0XM047008
- GC0XM046466
- GC0XM047200
- GC0XM047251
- GC0XM047962
- GC0XM048090
- GC0XM048205
- GC0XM045914
Summaries for SSX3 Gene
-
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. While some of the related SSX genes are involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas, this gene does not appear to be involved in such translocations. [provided by RefSeq, Jul 2013]
GeneCards Summary for SSX3 Gene
SSX3 (Synovial Sarcoma, X Breakpoint 3) is a Protein Coding gene. Diseases associated with SSX3 include Sarcoma and Sarcoma, Synovial. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is SSX2.
UniProtKB/Swiss-Prot for SSX3 Gene
-
Could act as a modulator of transcription.
No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSX3 Gene
Genomics for SSX3 Gene
Regulatory Elements for SSX3 Gene
Enhancers for SSX3 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around SSX3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SSX3 gene promoter:
Regulatory Element Products
Genomic Location for SSX3 Gene
- Chromosome:
- X
- Start:
- 48,346,428 bp from pter
- End:
- 48,356,753 bp from pter
- Size:
- 10,326 bases
- Orientation:
- Minus strand
Genomic View for SSX3 Gene
Genes around SSX3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp11.23 by Ensembl
- Xp11.23 by Entrez Gene
- Xp11.23 by HGNC
SSX3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SSX3 Gene
Proteins for SSX3 Gene
-
Protein details for SSX3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99909-SSX3_HUMAN
- Recommended name:
- Protein SSX3
- Protein Accession:
- Q99909
- O60223
- Q5JQZ3
- Q9BRW7
Protein attributes for SSX3 Gene
- Size:
- 188 amino acids
- Molecular mass:
- 21697 Da
- Quaternary structure:
-
- Interacts with SSX2IP.
Protein Expression for SSX3 Gene
Post-translational modifications for SSX3 Gene
Other Protein References for SSX3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SSX3
- Novus Biologicals Antibodies for SSX3
- Abcam antibodies for SSX3
- antibodies-online Antibodies for SSX3: See all 28
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-
Santa Cruz Biotechnology (SCBT) Antibodies for SSX3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for SSX3
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- antibodies-online Proteins for SSX3: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for SSX3
- Abcam proteins for SSX3
Assay Products
No data available for DME Specific Peptides for SSX3 Gene
Domains & Families for SSX3 Gene
Protein Domains for SSX3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SSX3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q99909- Domain:
-
- Contains 1 KRAB-related domain.
- Family:
-
- Belongs to the SSX family.
No data available for Gene Families for SSX3 Gene
Function for SSX3 Gene
Molecular function for SSX3 Gene
- GENATLAS Biochemistry:
- protein SSX3 with homology to Kruppel associated box,KRAB,not implicated in t(X;18) synovial sarcoma
- UniProtKB/Swiss-Prot Function:
- Could act as a modulator of transcription.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
Phenotypes for SSX3 Gene
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for SSX3 gene
-
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- Search ViGene Biosciences for SSX3
CRISPR Products
-
OriGene CRISPR knockouts for SSX3
-
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miRNA Products
- Search ViGene Biosciences for SSX3
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for SSX3 gene
Clone Products
- OriGene clones in human for SSX3
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for SSX3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SSX3 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SSX3 Gene
Localization for SSX3 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 3 |
| extracellular | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SSX3 Gene
Pathways & Interactions for SSX3 Gene
More details on SuperPathways for SSX3
No Data Available
Interacting Proteins for SSX3 Gene
Selected Interacting proteins:
ENSP00000298396
Q99909-SSX3_HUMAN
for SSX3 Gene via
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903507 | negative regulation of nucleic acid-templated transcription | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for SSX3 Gene
Transcripts for SSX3 Gene
mRNA/cDNA for SSX3 Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (10) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SSX3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SSX3
-
Santa Cruz Biotechnology (SCBT) CRISPR for SSX3
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miRNA Products
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Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for SSX3 gene
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Flow Cytometry Products
Expression for SSX3 Gene
mRNA differential expression in normal tissues according to GTEx for SSX3 Gene
This gene is overexpressed in Testis (x51.9).
This gene is overexpressed in Ovary (35.5) and Testis (33.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SSX3 Gene
SOURCE GeneReport for Unigene cluster for SSX3 Gene Hs.558445
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for SSX3
-
OriGene qPCR primer pairs and template standards for SSX3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SSX3 Gene
Orthologs for SSX3 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC737502 35 |
|
||
| SSX3 36 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | SSX5 36 |
|
OneToMany | |
| dog (Canis familiaris) |
Mammalia | -- 36 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Gm14459 36 |
|
ManyToMany | |
| Gm21876 36 |
|
ManyToMany | |||
| Gm5751 36 |
|
ManyToMany | |||
| Gm6592 36 |
|
ManyToMany | |||
| Ssx9 36 |
|
ManyToMany | |||
| Ssxa1 36 |
|
ManyToMany | |||
| Ssxb1 36 |
|
ManyToMany | |||
| Ssxb10 36 |
|
ManyToMany | |||
| Ssxb2 36 |
|
ManyToMany | |||
| Ssxb3 36 |
|
ManyToMany | |||
| Ssxb5 36 |
|
ManyToMany | |||
| Ssxb6 36 |
|
ManyToMany | |||
| Ssxb8 36 |
|
ManyToMany | |||
| Ssxb9 36 |
|
ManyToMany |
- Species with no ortholog for SSX3:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for SSX3 Gene
(16) SIMAP similar genes for SSX3 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for SSX3 Gene
Variants for SSX3 Gene
| SNP ID | Clin | Chr 0X pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs3014654 | -- | 48,352,399(+) | TATTC(C/G)ATTAC | intron-variant | |
| rs3014655 | -- | 48,352,549(+) | GTGTG(A/G)TGAAC | intron-variant | |
| rs3125215 | -- | 48,346,587(+) | TGTGT(C/G)TGTGT | utr-variant-3-prime | |
| rs3125216 | -- | 48,353,594(+) | cactc(C/T)accct | intron-variant | |
| rs3125217 | -- | 48,353,738(+) | CCTTA(A/G)TTTGA | intron-variant |
Residual Variation Intolerance Score:
66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.41;
9.03% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SSX3 Gene
Disorders for SSX3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| sarcoma |
|
|
| sarcoma, synovial |
|
Search SSX3 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for SSX3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- SSX3
No data available for UniProtKB/Swiss-Prot and Genatlas for SSX3 Gene
Publications for SSX3 Gene
- A novel Kruppel-associated box containing the SSX gene (SSX3) on the human X chromosome is not implicated in t(X;18)-positive synovial sarcomas. (PMID: 8697803) de Leeuw B. … Geurts van Kessel A. (Cytogenet. Cell Genet. 1996) 2 3 4 23 67
- SSX: a multigene family with several members transcribed in normal testis and human cancer. (PMID: 9378559) Gure A.O. … Chen Y.-T. (Int. J. Cancer 1997) 2 3 23
- The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PMID: 12007189) de Bruijn D.R.H. … van Kessel A.G. (Genes Chromosomes Cancer 2002) 3 23
- Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines. (PMID: 10749136) dos Santos N.R. … Geurts van Kessel A. (Cancer Res. 2000) 3 23
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
Products for SSX3 Gene
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- Custom Antibody ServicesOriGene Antibodies for SSX3
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- OriGene qPCR primer pairs for SSX3
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- antibodies-online Antibodies for SSX3: See all 28
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- antibodies-online Proteins for SSX3: See all 7
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- Search GeneTex for Antibodies for SSX3
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- ViGene Biosciences adenoviral particle packaged cDNA for SSX3 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for SSX3
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- Santa Cruz Biotechnology (SCBT) CRISPR for SSX3
Sources for SSX3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
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- (95) miRTarBase
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- (113) antibodies-online
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