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SSX3 Gene(Protein Coding)

SSX Family Member 3

GCID:
GC0XM048346
GIFtS:
49
Genes Participants
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Aliases for SSX3 Gene

Aliases for SSX3 Gene

  • SSX Family Member 3 2 3 5
  • Synovial Sarcoma, X Breakpoint 3 2 3
  • Cancer/Testis Antigen 5.3 3 4
  • CT5.3 3 4
  • Kruppel-Associated Box Containing Gene Product SSX3 3
  • Protein SSX3 3

External Ids for SSX3 Gene

Previous GeneCards Identifiers for SSX3 Gene

  • GC0XM047008
  • GC0XM046466
  • GC0XM047200
  • GC0XM047251
  • GC0XM047962
  • GC0XM048090
  • GC0XM048205
  • GC0XM045914

Summaries for SSX3 Gene

Entrez Gene Summary for SSX3 Gene

  • The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. While some of the related SSX genes are involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas, this gene does not appear to be involved in such translocations. [provided by RefSeq, Jul 2013]

GeneCards Summary for SSX3 Gene

SSX3 (SSX Family Member 3) is a Protein Coding gene. Diseases associated with SSX3 include Sarcoma and Sarcoma, Synovial. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is SSX7.

UniProtKB/Swiss-Prot for SSX3 Gene

  • Could act as a modulator of transcription.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSX3 Gene

Genomics for SSX3 Gene

Products:

  1. Regulatory Element

Regulatory Elements for SSX3 Gene

Enhancers for SSX3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF048789 1 FANTOM5 ENCODE 1.6 -433.0 -433012 0.5 CTCF STAT1 ZNF654 ZNF740 NFXL1 REST ZBTB7A RAD21 POLR2A NCOR1 GATA1 ENSG00000204620 SLC38A5 MAGIX SSX3 HDAC6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SSX3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SSX3 gene promoter:

Genomic Location for SSX3 Gene

Chromosome:
X
Start:
48,346,428 bp from pter
End:
48,356,753 bp from pter
Size:
10,326 bases
Orientation:
Minus strand

Genomic View for SSX3 Gene

Genes around SSX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSX3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SSX3 Gene

Proteins for SSX3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SSX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99909-SSX3_HUMAN
    Recommended name:
    Protein SSX3
    Protein Accession:
    Q99909
    Secondary Accessions:
    • O60223
    • Q5JQZ3
    • Q9BRW7

    Protein attributes for SSX3 Gene

    Size:
    188 amino acids
    Molecular mass:
    21697 Da
    Quaternary structure:
    • Interacts with SSX2IP.

    Alternative splice isoforms for SSX3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSX3 Gene

Protein Expression for SSX3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SSX3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SSX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SSX3 Gene

Domains & Families for SSX3 Gene

Protein Domains for SSX3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SSX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99909

UniProtKB/Swiss-Prot:

SSX3_HUMAN :
  • Contains 1 KRAB-related domain.
  • Belongs to the SSX family.
Domain:
  • Contains 1 KRAB-related domain.
Family:
  • Belongs to the SSX family.
genes like me logo Genes that share domains with SSX3: view

No data available for Gene Families for SSX3 Gene

Function for SSX3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for SSX3 Gene

GENATLAS Biochemistry:
protein SSX3 with homology to Kruppel associated box,KRAB,not implicated in t(X;18) synovial sarcoma
UniProtKB/Swiss-Prot Function:
Could act as a modulator of transcription.

Gene Ontology (GO) - Molecular Function for SSX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003714 transcription corepressor activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SSX3: view
genes like me logo Genes that share phenotypes with SSX3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SSX3 Gene

Localization for SSX3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSX3 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for SSX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with SSX3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SSX3 Gene

Pathways & Interactions for SSX3 Gene

SuperPathways for SSX3 Gene

PathCards logo More details on SuperPathways for SSX3
No Data Available

Gene Ontology (GO) - Biological Process for SSX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:1903507 negative regulation of nucleic acid-templated transcription IBA --
genes like me logo Genes that share ontologies with SSX3: view

No data available for Pathways by source and SIGNOR curated interactions for SSX3 Gene

Drugs & Compounds for SSX3 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for SSX3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for SSX3 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SSX3 Gene

Synovial sarcoma, X breakpoint 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSX3 Gene

No ASD Table

Relevant External Links for SSX3 Gene

GeneLoc Exon Structure for
SSX3
ECgene alternative splicing isoforms for
SSX3

Expression for SSX3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SSX3 Gene

mRNA expression in normal human tissues for SSX3 Gene
mRNA expression by BioGPS for SSX3 GenemRNA expression by GTEx for SSX3 Gene

mRNA differential expression in normal tissues according to GTEx for SSX3 Gene

This gene is overexpressed in Testis (x51.9).

Protein differential expression in normal tissues from HIPED for SSX3 Gene

This gene is overexpressed in Ovary (35.5) and Testis (33.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SSX3 Gene



Protein tissue co-expression partners for SSX3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SSX3 Gene:

SSX3

SOURCE GeneReport for Unigene cluster for SSX3 Gene:

Hs.558445
genes like me logo Genes that share expression patterns with SSX3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SSX3 Gene

Orthologs for SSX3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SSX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia SSX3 35
  • 96 (a)
 OneToOne
LOC737502 34
  • 94.33 (n)
dog
(Canis familiaris)
 Mammalia -- 35
  • 47 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Ssxa1 35
  • 47 (a)
 ManyToMany
Gm21876 35
  • 41 (a)
 ManyToMany
Gm5751 35
  • 35 (a)
 ManyToMany
Ssxb5 35
  • 35 (a)
 ManyToMany
Ssxb1 35
  • 34 (a)
 ManyToMany
Ssxb10 35
  • 34 (a)
 ManyToMany
Ssxb8 35
  • 34 (a)
 ManyToMany
Ssxb3 35
  • 33 (a)
 ManyToMany
Gm14459 35
  • 32 (a)
 ManyToMany
Gm6592 35
  • 32 (a)
 ManyToMany
Ssx9 35
  • 32 (a)
 ManyToMany
Ssxb9 35
  • 32 (a)
 ManyToMany
Ssxb2 35
  • 31 (a)
 ManyToMany
Ssxb6 35
  • 28 (a)
 ManyToMany
cow
(Bos Taurus)
 Mammalia SSX5 35
  • 28 (a)
 OneToMany
Species where no ortholog for SSX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SSX3 Gene

ENSEMBL:
Gene Tree for SSX3 (if available)
TreeFam:
Gene Tree for SSX3 (if available)

Paralogs for SSX3 Gene

Variants for SSX3 Gene

Sequence variations from dbSNP and Humsavar for SSX3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs112625608 -- 48,357,307(+) GCCCT(A/G)GAGAG upstream-variant-2KB
rs112850154 -- 48,357,379(+) CCTCC(C/T)GCCTC upstream-variant-2KB
rs11323384 -- 48,355,580(+) TATGG(-/A)CCCTT intron-variant
rs113398904 -- 48,353,846(+) GAATG(A/G)CCTCT intron-variant
rs113403735 -- 48,354,694(+) AGACT(C/T)TCATC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SSX3 Gene

Variant ID Type Subtype PubMed ID
esv25781 CNV gain 19812545
esv2671998 CNV deletion 23128226
esv32909 CNV gain+loss 17666407
nsv508769 CNV insertion 20534489
nsv523595 CNV gain 19592680
nsv7441 OTHER inversion 18451855

Variation tolerance for SSX3 Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSX3 Gene

Disorders for SSX3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SSX3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sarcoma
  • connective and soft tissue neoplasm
sarcoma, synovial
  • synovial sarcoma
malignant melanoma, somatic
  • dysplastic nevus syndrome
- elite association - COSMIC cancer census association via MalaCards
Search SSX3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SSX3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSX3
genes like me logo Genes that share disorders with SSX3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSX3 Gene

Publications for SSX3 Gene

  1. SSX: a multigene family with several members transcribed in normal testis and human cancer. (PMID: 9378559) Gure A.O. … Chen Y.-T. (Int. J. Cancer 1997) 2 3 4 22 64
  2. A novel Kruppel-associated box containing the SSX gene (SSX3) on the human X chromosome is not implicated in t(X;18)-positive synovial sarcomas. (PMID: 8697803) de Leeuw B. … Geurts van Kessel A. (Cytogenet. Cell Genet. 1996) 2 3 4 22 64
  3. The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PMID: 12007189) de Bruijn D.R.H. … van Kessel A.G. (Genes Chromosomes Cancer 2002) 3 4 22 64
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SSX3 Gene

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