Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SSX2IP Gene

protein-coding GIFtS: 55
GCID: GC01M085109

Synovial Sarcoma, X Breakpoint 2 Interacting Protein

7 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Synovial Sarcoma, X Breakpoint 2 Interacting Protein¹ ²
Afadin DIL Domain-Interacting Protein² ³
ADIP² ³
SSX2-Interacting Protein² ³
Afadin- And Alpha-Actinin-Binding Protein²
KIAA0923³

External Ids:	HGNC: 16509¹	Entrez Gene: 117178²	Ensembl: ENSG00000117155⁷	OMIM: 608690⁵	UniProtKB: Q9Y2D8³

Export aliases for SSX2IP gene to outside databases

Previous GC identifers: GC00U991126 GC01M084247 GC01M084397 GC01M084531 GC01M084532 GC01M084821 GC01M084881 GC01M083219

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SSX2IP Gene:

This gene encodes a protein that binds the cancer-testis antigen Synovial Sarcoma X breakpoint 2 protein. The

encoded protein may regulate the activity of Synovial Sarcoma X breakpoint 2 protein in malignant cells.

Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3.

(provided by RefSeq, Oct 2009)

GeneCards Summary for SSX2IP Gene:

SSX2IP (synovial sarcoma, X breakpoint 2 interacting protein) is a protein-coding gene. Diseases associated with SSX2IP include constrictive pericarditis, and synovial sarcoma, and among its related super-pathways are PAK Pathway. GO annotations related to this gene include protein binding and protein domain specific binding.

UniProtKB/Swiss-Prot: ADIP_HUMAN, Q9Y2D8

Function: Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and

heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system

through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and

alpha-actinin (By similarity)

Gene Wiki entry for SSX2IP Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NT_032977.9 NC_018912.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SSX2IP gene promoter:
GATA-3 Bach2 ATF-2 POU3F2 (N-Oct-5a) POU3F2 GATA-2 Evi-1 S8 NF-Y CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SSX2IP promoter sequence

Search SABiosciences Chromatin IP Primers for SSX2IP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSX2IP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.3 Ensembl cytogenetic band: 1p22.3 HGNC cytogenetic band: 1p22.3

SSX2IP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSX2IP gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M085109: view genomic region (about GC identifiers)

Start:	85,109,390 bp from pter	End:	85,156,486 bp from pter
Size:	47,097 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADIP_HUMAN, Q9Y2D8 (See protein sequence)

Recommended Name: Afadin- and alpha-actinin-binding protein

Size: 614 amino acids; 71236 Da

Subunit: Interacts with afadin and alpha-actinin (By similarity). Interacts with SSX2 and SSX3. Does not interact

with SSX1 and SSX4

Subcellular location: Cell junction, adherens junction (By similarity). Nucleus. Note=Not found at cell-matrix AJs

(By similarity)

Sequence caution: Sequence=BAA76767.2; Type=Erroneous initiation;

Secondary accessions: A8K8W0 B4DFE3 D3DT13 J3KR02 Q6P2P8 Q6ULS1 Q7L168 Q9UIX0

Alternative splicing: 3 isoforms: Q9Y2D8-1 Q9Y2D8-2 Q9Y2D8-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SSX2IP: NX_Q9Y2D8

Explore proteomics data for SSX2IP at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9Y2D8

SSX2IP Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (5 alternative transcripts):

NP_001159765.1 NP_001159766.1 NP_001159767.1 NP_001159889.1 NP_054740.3

ENSEMBL proteins:

ENSP00000340279 ENSP00000432261 ENSP00000474925 ENSP00000474480 ENSP00000473763

ENSP00000416067 ENSP00000412781 ENSP00000359644

Human Recombinant Protein Products for SSX2IP:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for SSX2IP OriGene Custom MassSpec OriGene Custom Protein Services for SSX2IP
	GenScript Custom Purified and Recombinant Proteins Services for SSX2IP
	Novus Biologicals SSX2IP Protein Novus Biologicals SSX2IP Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005913	cell-cell adherens junction	IEA	--
GO:0031252	cell leading edge	IEA	--
GO:0043234	protein complex	IDA	--

SSX2IP for ontologies About GeneDecksing

SSX2IP Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for SSX2IP
	GenScript Custom Superior Antibodies Services for SSX2IP
	Novus Biologicals SSX2IP Antibodies
	Abcam antibodies for SSX2IP
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for SSX2IP
	LSBio Antibodies in human, mouse, rat for SSX2IP

Assay Products for SSX2IP:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for SSX2IP
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SSX2IP
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro protein domain:

IPR021622 Afadin/alpha-actinin-bd

Graphical View of Domain Structure for InterPro Entry Q9Y2D8

ProtoNet protein and cluster: Q9Y2D8

UniProtKB/Swiss-Prot: ADIP_HUMAN, Q9Y2D8

Domain: Both the N-terminal (up to position 79) and the C-terminal (from position 304) sequences are required for

interaction with SSX2

SSX2IP for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ADIP_HUMAN, Q9Y2D8

Function: Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and

heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system

through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and

alpha-actinin (By similarity)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	12007189
GO:0019904	protein domain specific binding	IEA	--

SSX2IP for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for SSX2IP

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SSX2IP

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SSX2IP

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SSX2IP

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSX2IP
		8/102 QIAGEN miScript miRNA Assays for microRNAs that regulate SSX2IP (see all 102):
		hsa-miR-576-3p hsa-miR-3607-3p hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-4272 hsa-miR-106a hsa-miR-30d

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for SSX2IP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSX2IP

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SSX2IP
			Sirion Biotech Customized adenovirus for overexpression of SSX2IP

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for SSX2IP (see all 20) OriGene ORF clones in mouse, rat for SSX2IP OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): SSX2IP (NM_014021)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSX2IP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSX2IP
		Sirion Biotech Customized lentivirus for stable overexpression of SSX2IP Customized lentivirus expression plasmids for stable overexpression of SSX2IP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SSX2IP
		Search LifeMap BioReagents cell lines for SSX2IP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSX2IP

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for SSX2IP About

See pathways by source

SuperPath

Contained pathways About

PAK Pathway

Epithelial Adherens Junctions

0.36

Adherens junction

Adherens junction

Pathways by source See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SSX2IP

Epithelial Adherens Junctions

1 Kegg Pathway (Kegg details for SSX2IP):

Adherens junction

SSX2IP for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SSX2IP

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/20 Interacting proteins for SSX2IP (Q9Y2D8^{1, 2, 3} ENSP00000340279⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SSX2	Q16385¹^,³, ENSP00000338796⁴	EBI-2212028,EBI-2210673 I2D: score=2 STRING: ENSP00000338796
SSX2B	Q16385¹^,³	EBI-2212028,EBI-2210673 I2D: score=2
ACTN2	P35609³, ENSP00000355537⁴	I2D: score=1 STRING: ENSP00000355537
SSX3	Q99909³, ENSP00000298396⁴	I2D: score=1 STRING: ENSP00000298396
MLLT4	P55196³, ENSP00000383623⁴	I2D: score=2 STRING: ENSP00000383623

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	IEA	--
GO:0035020	regulation of Rac protein signal transduction	IEA	--
GO:2000145	regulation of cell motility	IEA	--

SSX2IP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SSX2IP (ADIP)

Search CenterWatch for drugs/clinical trials and news about SSX2IP / ADIP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SSX2IP gene (5 alternative transcripts):

NM_001166293.1 NM_001166294.1 NM_001166295.1 NM_001166417.1 NM_014021.3

Unigene Cluster for SSX2IP:

Synovial sarcoma, X breakpoint 2 interacting protein

Hs.22587 [show with all ESTs]

Unigene Representative Sequence: NM_001166417

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000342203(uc001dkf.3 uc001dki.3 uc010osa.2 uc001dkj.3)

ENST00000481102(uc009wci.3) ENST00000476905(uc001dkk.1) ENST00000605755

ENST00000603677 ENST00000490476 ENST00000459708 ENST00000460500 ENST00000422026

ENST00000437941(uc001dkh.3 uc010orz.2 uc001dkg.3) ENST00000370612

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSX2IP
		8/102 QIAGEN miScript miRNA Assays for microRNAs that regulate SSX2IP (see all 102):
		hsa-miR-576-3p hsa-miR-3607-3p hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-4272 hsa-miR-106a hsa-miR-30d

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for SSX2IP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSX2IP

Clone Products:		OriGene clones in human, mouse for SSX2IP (see all 20) OriGene ORF clones in mouse, rat for SSX2IP OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): SSX2IP (NM_014021)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSX2IP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSX2IP
		Sirion Biotech Customized lentivirus for stable overexpression of SSX2IP Customized lentivirus expression plasmids for stable overexpression of SSX2IP

Primer Products:		OriGene qPCR primer pairs and template standards for SSX2IP OriGene qSTAR qPCR primer pairs in human, mouse for SSX2IP
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SSX2IP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSX2IP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSX2IP

Additional mRNA sequence:

AB023140.1 AK001710.1 AK021515.1 AK023097.1 AK292475.1 AK294057.1 AK307336.1 AK316472.1

AL133046.1 AY367055.1 AY651262.1 BC033637.1 BC035580.1 BC064389.1

12 DOTS entries:

DT.443120 DT.91724867 DT.95364110 DT.91819070 DT.87046250 DT.100027963 DT.97818472 DT.95148373

DT.95364109 DT.121357808 DT.40124571 DT.100793289

24/226 AceView cDNA sequences (see all 226):

F05006 BM721181 AI572351 AU133150 F12492 AA743113 BM728884 CB159291

AA307820 AI274784 CA428511 AA721219 AI421459 AL133046 BI520350 CA415280

BU631256 BM679602 CR611558 F02193 AB023140 AI286099 AW592781 AI453170

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SSX2IP (see all 7) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15a	·	15b
SP1:			-																																-		-
SP2:																													-						-
SP3:																													-						-		-
SP4:																													-						-		-
SP5:

ECgene alternative splicing isoforms for SSX2IP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SSX2IP expression in normal human tissues (normalized intensities) SSX2IP embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CACTCACCCT

About this image

SSX2IP expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/6 selected tissues (see all 6) fully expand


Testis (Reproductive System) fully expand to see all 3 entries
Leydig Cells Testis Interstitium
Testis Interstitium

Blood (Hematopoietic System) fully expand to see all 2 entries
Proerythroblasts Hematopoietic Bone Marrow
cord blood

Intestine (Gastrointestinal Tract)
small intestine

Umbilical Cord (Extraembryonic Tissues)
cord blood

Eye (Sensory Organs)
lens

See SSX2IP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SSX2IP

SOURCE GeneReport for Unigene cluster: Hs.22587

UniProtKB/Swiss-Prot: ADIP_HUMAN, Q9Y2D8

Tissue specificity: Widely expressed, with the highest expression in brain, intermediate expression in kidney,

testis, spinal cord, liver, heart, lung, skeletal muscle, ovary, fetal liver and fetal brain, and little to no

expression in pancreas and spleen. All specific brain regions showed intermediate to high expression, with

highest expression in amygdala. Also expressed in fetal tissues, mainly in liver and brain

SABiosciences Expression via Pathway-Focused PCR Array including SSX2IP:

Adherens Junctions in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for SSX2IP OriGene qSTAR qPCR primer pairs in human, mouse for SSX2IP
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SSX2IP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSX2IP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSX2IP

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSX2IP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SSX2IP gene from 7/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ssx2ip^{1 , 5}	synovial sarcoma, X breakpoint 2 interacting protein^{1, 5}	84.15(n)¹ 87.62(a)¹		3 (71.03 cM)⁵ 99167¹ NM_138744.3¹ NP_620083.1¹ 146404642⁵
chicken (Gallus gallus)	Aves	SSX2IP¹	synovial sarcoma, X breakpoint 2 interacting protein	75.64(n) 75.27(a)		424532 NM_001044656.1 NP_001038121.1
lizard (Anolis carolinensis)	Reptilia	SSX2IP⁶ -- (see all 3)	Uncharacterized protein (see all 3)	69(a) 36(a) (see all 3)	1 ↔ 1 possible ortholog (see all 3)	GL343194.1(9853238-9888522) 5(121583218-121586505)
African clawed frog (Xenopus laevis)	Amphibia	BU914026.1²	--	75.79(n)		BU914026.1
zebrafish (Danio rerio)	Actinopterygii	zgc73314²	hypothetical protein MGC73314	72.7(n)		393808 BC060934.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G18876¹	Afadin/alpha-actinin-binding protein	43.14(n) 26.73(a)		816403 NM_179650.1 NP_849981.1
rice (Oryza sativa)	Liliopsida	Os08g0242900¹	hypothetical protein	42.44(n) 27.33(a)		4345045 NM_001067879.1 NP_001061344.1

ENSEMBL Gene Tree for SSX2IP (if available)
TreeFam Gene Tree for SSX2IP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SSX2IP gene

SSX2IP for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SSX2IP
PGOHUM00000237700

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10874454^1,2	C,F,A,H	--	85108904(+)	`CAGCAG/ATAAAC`	5	--	ds500¹		14		NS EA NA WA	724
rs192426961^1,2		--	85108971(+)	`AGATTG/TTAAGT`	5	--	ds500¹		0	--	--	--	--
rs145755469^1,2		--	85108975(+)	`TGTAAC/GTGCTC`	5	--	ds500¹		0	--	--	--	--
rs138357268^1,2		--	85109034(+)	`CTGTAA/GGTGGA`	5	--	ds500¹		0	--	--	--	--
rs185019849^1,2		--	85109051(+)	`GTCTCC/TTTCAG`	5	--	ds500¹		0	--	--	--	--
rs149251321^1,2		--	85109256(+)	`ATACTC/GTATAT`	5	--	ds500¹		0	--	--	--	--
rs147063387^1,2	C	--	85109333(+)	`AGAAA-/GAGGAGTT`	5	--	ds500¹		0	--	--	--	--
rs143801457^1,2		--	85109364(+)	`ACTTAC/TAGTCC`	5	--	ds500¹		0	--	--	--	--
rs188309607^1,2		--	85109366(+)	`TTATAA/GTCCAT`	5	--	ds500¹		0	--	--	--	--
rs193193240^1,2		--	85109453(+)	`CTAGGC/TACATG`	5	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SSX2IP (85109390 - 85156486 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for SSX2IP: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSX2IP

DNA2.0 Custom Variant and Variant Library Synthesis for SSX2IP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 608690 OMIM disorders: --

7 diseases for SSX2IP: About MalaCards

constrictive pericarditis synovial sarcoma pericarditis sarcoma

acute myeloid leukemia myeloid leukemia leukemia

1 disease from the University of Copenhagen DISEASES database for SSX2IP:

Constrictive pericarditis

SSX2IP for disorders About GeneDecksing

Genetic Association Database (GAD): SSX2IP

Export disorders for SSX2IP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SSX2IP gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with SSX2IP)

Utopia: connect your pdf to the dynamic
world of online information

The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PubMed id 12007189)^{1, 2, 9} de Bruijn D.R.H....van Kessel A.G. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)^{1, 2} Nagase T.... Ohara O. (1999)
SSX2IP: an emerging role in cancer. (PubMed id 17904521)^{1, 9} Breslin A....Guinn B.A. (2007)
Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia. (PubMed id 16112646)^{1, 9} Guinn B.-A.... Mufti G.J. (2005)
A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)¹ Weimann M.... Stelzl U. (2013)
SSX2IP promotes metastasis and chemotherapeutic resist ance of hepatocellular carcinoma. (PubMed id 23452395)¹ Li P....Huo K. (2013)
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 117178	HGNC: 16509	AceView: SSX2IP	Ensembl:ENSG00000117155	euGenes: HUgn117178
ECgene: SSX2IP	Kegg: 117178	H-InvDB: SSX2IP

(According to HUGE)
About This Section

HUGE: KIAA0923

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SSX2IP	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SSX2IP	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SSX2IP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SSX2IP gene:
Search GeneIP for patents involving SSX2IP

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for SSX2IP
	OriGene qPCR primer pairs and template standards for SSX2IP		OriGene Protein Over-expression Lysate for SSX2IP
	OriGene Custom Mass Spec		OriGene clones in human, mouse for SSX2IP
	OriGene qSTAR qPCR primer pairs in human, mouse for SSX2IP		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for SSX2IP		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SSX2IP		OriGene Custom Protein Services for SSX2IP

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SSX2IP
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSX2IP
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSX2IP
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSX2IP
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSX2IP
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSX2IP

	GenScript Custom Purified and Recombinant Proteins Services for SSX2IP		GenScript cDNA clones with any tag delivered in your preferred vector for SSX2IP
	GenScript Custom Assay Services for SSX2IP		GenScript Custom Superior Antibodies Services for SSX2IP
	GenScript Custom overexpressing Cell Line Services for SSX2IP		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in SSX2IP promoter
	Search Chromatin IP Primers for SSX2IP
	RT² qPCR Primer Assay in human, mouse, rat SSX2IP
	GNC Network for SSX2IP
	SABiosciences PCR Arrays including human, mouse, rat SSX2IP

Search Tocris compounds for SSX2IP (ADIP)

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SSX2IP antibodies
	SSX2IP proteins
	SSX2IP lysates

	Antibodies for SSX2IP
	See all of Abcam's Antibodies, Kits and Proteins for SSX2IP
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Browse Proteins at Cloud-Clone Corp.
	Browse Antibodies at Cloud-Clone Corp.
	Browse ELISAs at Cloud-Clone Corp.
	Browse CLIAs at Cloud-Clone Corp.

Search LifeMap BioReagents cell lines for SSX2IP

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSX2IP

	Browse SwitchGear 3'UTR luciferase reporter plasmids for SSX2IP
	SwitchGear Promoter luciferase reporter plasmids for SSX2IP

ThermoFisher Antibodies for SSX2IP

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSX2IP

	inGenious Targeting Laboratory - Custom generated mouse model solutions for SSX2IP
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SSX2IP

Customized:

	lentivirus for stable overexpression of SSX2IP
	lentivirus expression plasmids for stable overexpression of SSX2IP
	adenovirus for overexpression of SSX2IP

LSBio Antibodies in human, mouse, rat for SSX2IP

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SSX2IP gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

SSX2IP Gene

Synovial Sarcoma, X Breakpoint 2 Interacting Protein

Aliases
for SSX2IP gene

Summaries
for SSX2IP gene

Genomic Views
for SSX2IP gene

Proteins
for SSX2IP gene

Protein Domains /
Families
for SSX2IP gene

Function
for SSX2IP gene

Pathways & Interactions
for SSX2IP gene

Drugs & Compounds
for SSX2IP gene

Transcripts
for SSX2IP gene

Expression
for SSX2IP gene

Orthologs
for SSX2IP gene

Paralogs
for SSX2IP gene

Genomic Variants
for SSX2IP gene

Disorders / Diseases
for SSX2IP gene

Publications
for SSX2IP gene

External Searches for SSX2IP gene

Genome Databases showing SSX2IP gene

Other Databases showing SSX2IP gene

Specialized Databases showing SSX2IP gene

Intellectual Property
for SSX2IP gene

Products
for SSX2IP gene

View Random Gene

Advanced Search

Export list of displayed genes

SSX2IP Gene

Synovial Sarcoma, X Breakpoint 2 Interacting Protein

Aliasesfor SSX2IP gene

Summariesfor SSX2IP gene

Genomic Viewsfor SSX2IP gene

Proteinsfor SSX2IP gene

Protein Domains /Familiesfor SSX2IP gene

Functionfor SSX2IP gene

Pathways & Interactionsfor SSX2IP gene

Drugs & Compoundsfor SSX2IP gene

Transcriptsfor SSX2IP gene

Expression for SSX2IP gene

Orthologsfor SSX2IP gene

Paralogsfor SSX2IP gene

Genomic Variantsfor SSX2IP gene

Disorders / Diseasesfor SSX2IP gene

Publicationsfor SSX2IP gene

External Searches for SSX2IP gene

Genome Databases showing SSX2IP gene

Other Databases showing SSX2IP gene

Specialized Databases showing SSX2IP gene

Intellectual Propertyfor SSX2IP gene

Productsfor SSX2IP gene

View Random Gene

Aliases
for SSX2IP gene

Summaries
for SSX2IP gene

Genomic Views
for SSX2IP gene

Proteins
for SSX2IP gene

Protein Domains /
Families
for SSX2IP gene

Function
for SSX2IP gene

Pathways & Interactions
for SSX2IP gene

Drugs & Compounds
for SSX2IP gene

Transcripts
for SSX2IP gene

Expression
for SSX2IP gene

Orthologs
for SSX2IP gene

Paralogs
for SSX2IP gene

Genomic Variants
for SSX2IP gene

Disorders / Diseases
for SSX2IP gene

Publications
for SSX2IP gene

Intellectual Property
for SSX2IP gene

Products
for SSX2IP gene