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SSX2IP Gene

protein-coding   GIFtS: 57
GCID: GC01M085109

Synovial Sarcoma, X Breakpoint 2 Interacting Protein

  See SSX2IP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Synovial Sarcoma, X Breakpoint 2 Interacting Protein1 2
Afadin DIL Domain-Interacting Protein2 3
ADIP2 3
SSX2-Interacting Protein2 3
Afadin- And Alpha-Actinin-Binding Protein2
KIAA09233

External Ids:    HGNC: 165091   Entrez Gene: 1171782   Ensembl: ENSG000001171557   OMIM: 6086905   UniProtKB: Q9Y2D83   

Export aliases for SSX2IP gene to outside databases

Previous GC identifers: GC00U991126 GC01M084247 GC01M084397 GC01M084531 GC01M084532 GC01M084821 GC01M084881 GC01M083219


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SSX2IP Gene:
This gene encodes a protein that binds the cancer-testis antigen Synovial Sarcoma X breakpoint 2 protein. The
encoded protein may regulate the activity of Synovial Sarcoma X breakpoint 2 protein in malignant cells.
Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3.
(provided by RefSeq, Oct 2009)

GeneCards Summary for SSX2IP Gene:
SSX2IP (synovial sarcoma, X breakpoint 2 interacting protein) is a protein-coding gene. Diseases associated with SSX2IP include constrictive pericarditis, and synovial sarcoma. GO annotations related to this gene include protein domain specific binding.

UniProtKB/Swiss-Prot: ADIP_HUMAN, Q9Y2D8
Function: Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and
heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system
through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and
alpha-actinin. Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and
is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of
Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of
the pericentriolar material and proper microtubule nucleation at mitotic spindle poles

Gene Wiki entry for SSX2IP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SSX2IP gene promoter:
         GATA-3   Bach2   ATF-2   POU3F2 (N-Oct-5a)   POU3F2   GATA-2   Evi-1   S8   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSSX2IP promoter sequence
   Search Chromatin IP Primers for SSX2IP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SSX2IP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.3   Ensembl cytogenetic band:  1p22.3   HGNC cytogenetic band: 1p22.3

SSX2IP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSX2IP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M085109:  view genomic region     (about GC identifiers)

Start:
85,109,390 bp from pter      End:
85,156,486 bp from pter
Size:
47,097 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ADIP_HUMAN, Q9Y2D8 (See protein sequence)
Recommended Name: Afadin- and alpha-actinin-binding protein  
Size: 614 amino acids; 71236 Da
Subunit: Interacts with afadin and alpha-actinin. Interacts with VAV2 (By similarity). Interacts with SSX2 and
SSX3. Does not interact with SSX1 and SSX4
Developmental stage: Expressed in interphase and M phase cells. Down-regulated by the miRNA miR338-3p
Miscellaneous: Acts as an acute myeloid leukemia-associated antigen and may be used as a potential immunotherapy
target for leukemia (PubMed:17686061, PubMed:19179477)
Sequence caution: Sequence=BAA76767.2; Type=Erroneous initiation;
Secondary accessions: A8K8W0 B4DFE3 D3DT13 J3KR02 Q6P2P8 Q6ULS1 Q7L168 Q9UIX0
Alternative splicing: 3 isoforms:  Q9Y2D8-1   Q9Y2D8-2   Q9Y2D8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SSX2IP: NX_Q9Y2D8

Explore proteomics data for SSX2IP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys112, Lys476, Lys535
  • Modification sites at PhosphoSitePlus

  • See SSX2IP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001159765.1  NP_001159766.1  NP_001159767.1  NP_001159889.1  NP_054740.3  

    ENSEMBL proteins: 
     ENSP00000340279   ENSP00000432261   ENSP00000474925   ENSP00000474480   ENSP00000473763  
     ENSP00000416067   ENSP00000412781   ENSP00000359644  

    SSX2IP Human Recombinant Protein Products:

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    Novus Biologicals SSX2IP Protein
    Novus Biologicals SSX2IP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for SSX2IP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR021622 Afadin/alpha-actinin-bd

    Graphical View of Domain Structure for InterPro Entry Q9Y2D8

    ProtoNet protein and cluster: Q9Y2D8

    UniProtKB/Swiss-Prot: ADIP_HUMAN, Q9Y2D8
    Domain: Both the N-terminal (up to position 79) and the C-terminal (from position 304) sequences are required for
    interaction with SSX2
    Similarity: Belongs to the ADIP family


    Find genes that share domains with SSX2IP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADIP_HUMAN, Q9Y2D8
    Function: Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and
    heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system
    through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and
    alpha-actinin. Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and
    is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of
    Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of
    the pericentriolar material and proper microtubule nucleation at mitotic spindle poles

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12007189
    GO:0019904protein domain specific binding IEA--
         
    Find genes that share ontologies with SSX2IP           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SSX2IP
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    miRNA
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    miRTarBase miRNAs that target SSX2IP:
    hsa-mir-92a-3p (MIRT049125), hsa-mir-193b-3p (MIRT016383), hsa-mir-339-5p (MIRT042758), hsa-mir-155-5p (MIRT020713)

    Block miRNA regulation of human, mouse, rat SSX2IP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SSX2IP (see all 102):
    hsa-miR-576-3p hsa-miR-3607-3p hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-4272 hsa-miR-106a hsa-miR-30d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SSX2IP

    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSX2IP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADIP_HUMAN, Q9Y2D8: Cell junction, adherens junction (By similarity). Nucleus. Cytoplasm, cytoskeleton,
    microtubule organizing center, centrosome, centriolar satellite. Note=Not found at cell-matrix AJs (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005913cell-cell adherens junction IEA--
    GO:0031252cell leading edge IEA--
    GO:0034451centriolar satellite IDA--
    GO:0043234protein complex IDA--

    Find genes that share ontologies with SSX2IP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SSX2IP About    
    See pathways by source

    SuperPathContained pathways About
    1PAK Pathway
    Epithelial Adherens Junctions0.36
    2Adherens junction
    Adherens junction


    Find genes that share SuperPaths with SSX2IP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SSX2IP
        Epithelial Adherens Junctions


    1 Kegg Pathway  (Kegg details for SSX2IP):
        Adherens junction

        Pathway & Disease-focused RT2 Profiler PCR Array including SSX2IP: 
              Adherens Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SSX2IP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for SSX2IP (Q9Y2D81, 2, 3 ENSP000003402794) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SSX2Q163851, 3, ENSP000003387964EBI-2212028,EBI-2210673 I2D: score=2 STRING: ENSP00000338796
    SSX2BQ163851, 3EBI-2212028,EBI-2210673 I2D: score=2 
    ACTN2P356093, ENSP000003555374I2D: score=1 STRING: ENSP00000355537
    SSX3Q999093, ENSP000002983964I2D: score=1 STRING: ENSP00000298396
    USP11P517843, ENSP000002183484I2D: score=2 STRING: ENSP00000218348
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0035020regulation of Rac protein signal transduction IEA--
    GO:0051297centrosome organization IMP--
    GO:2000145regulation of cell motility IEA--

    Find genes that share ontologies with SSX2IP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SSX2IP (ADIP)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SSX2IP gene (5 alternative transcripts): 
    NM_001166293.1  NM_001166294.1  NM_001166295.1  NM_001166417.1  NM_014021.3  

    Unigene Cluster for SSX2IP:

    Synovial sarcoma, X breakpoint 2 interacting protein
    Hs.22587  [show with all ESTs]
    Unigene Representative Sequence: NM_001166417
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342203(uc001dkf.3 uc001dki.3 uc010osa.2 uc001dkj.3)
    ENST00000481102(uc009wci.3) ENST00000476905(uc001dkk.1) ENST00000605755
    ENST00000603677 ENST00000490476 ENST00000459708 ENST00000460500 ENST00000422026
    ENST00000437941(uc001dkh.3 uc010orz.2 uc001dkg.3) ENST00000370612

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SSX2IP (see all 102):
    hsa-miR-576-3p hsa-miR-3607-3p hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-4272 hsa-miR-106a hsa-miR-30d
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    GenScript: all cDNA clones in your preferred vector (see all 5): SSX2IP (NM_014021)
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    Primer
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    OriGene qPCR primer pairs and template standards for SSX2IP
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SSX2IP
      QuantiTect SYBR Green Assays in human, mouse, rat SSX2IP
      QuantiFast Probe-based Assays in human, mouse, rat SSX2IP

    Additional mRNA sequence: 

    AB023140.1 AK001710.1 AK021515.1 AK023097.1 AK292475.1 AK294057.1 AK307336.1 AK316472.1 
    AL133046.1 AY367055.1 AY651262.1 BC033637.1 BC035580.1 BC064389.1 

    12 DOTS entries:

    DT.443120  DT.91724867  DT.95364110  DT.91819070  DT.87046250  DT.100027963  DT.97818472  DT.95148373 
    DT.95364109  DT.121357808  DT.40124571  DT.100793289 

    Selected AceView cDNA sequences (see all 226):

    AU133150 BC064389 BU631256 CA415280 BU618267 AI565298 Z45825 BU633035 
    BM721181 BQ424849 BU742907 BG291491 CA446442 AI375402 AA721219 AI421459 
    AL133046 AI274784 BE465593 BI520350 CR613292 BF195136 AW593744 AI453170 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SSX2IP (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:        -                                                                                               -     -               
    SP2:                                                                                      -                 -                     
    SP3:                                                                                      -                 -     -               
    SP4:                                                                                      -                 -     -               
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for SSX2IP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SSX2IP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTCACCCT
    SSX2IP Expression
    About this image


    SSX2IP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    SSX2IP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SSX2IP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.22587

    UniProtKB/Swiss-Prot: ADIP_HUMAN, Q9Y2D8
    Tissue specificity: Widely expressed, with the highest expression in brain, intermediate expression in kidney,
    testis, spinal cord, liver, heart, lung, skeletal muscle, ovary, fetal liver and fetal brain, and little to no
    expression in pancreas and spleen. All specific brain regions showed intermediate to high expression, with
    highest expression in amygdala. Also expressed in fetal tissues, mainly in liver and brain

        Pathway & Disease-focused RT2 Profiler PCR Array including SSX2IP: 
              Adherens Junctions in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for SSX2IP
    OriGene qSTAR qPCR primer pairs in human, mouse for SSX2IP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SSX2IP
    QuantiTect SYBR Green Assays in human, mouse, rat SSX2IP
    QuantiFast Probe-based Assays in human, mouse, rat SSX2IP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSX2IP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SSX2IP gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ssx2ip1 , 5 synovial sarcoma, X breakpoint 2 interacting protein1, 5 84.15(n)1
    87.62(a)1
      3 (71.03 cM)5
    991671  NM_138744.31  NP_620083.11 
     1464046425 
    chicken
    (Gallus gallus)
    Aves SSX2IP1 synovial sarcoma, X breakpoint 2 interacting protein 75.76(n)
    75.27(a)
      424532  NM_001044656.1  NP_001038121.1 
    lizard
    (Anolis carolinensis)
    Reptilia SSX2IP6
    synovial sarcoma, X breakpoint 2 interacting prote...
    69(a)
    1 ↔ 1
    GL343194.1(9853238-9888522)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU914026.12   -- 75.79(n)    BU914026.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc733142 hypothetical protein MGC73314 72.7(n)   393808  BC060934.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G188761 AT2G18876 46.96(n)
    32(a)
      816403  NM_179650.1  NP_849981.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g02429001 Os08g0242900 44.68(n)
    29.82(a)
      4345045  NM_001067879.1  NP_001061344.1 


    ENSEMBL Gene Tree for SSX2IP (if available)
    TreeFam Gene Tree for SSX2IP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SSX2IP gene

    Find genes that share paralogs with SSX2IP           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SSX2IP
    PGOHUM00000237700


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SSX2IP (see all 1005)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs108744541,2
    C,F,A,H--85108904(+) CAGCAG/ATAAAC 5 -- ds500114Minor allele frequency- A:0.45NS EA NA WA 724
    rs1924269611,2
    --85108971(+) AGATTG/TTAAGT 5 -- ds50010--------
    rs1457554691,2
    --85108975(+) TGTAAC/GTGCTC 5 -- ds50010--------
    rs1383572681,2
    --85109034(+) CTGTAA/GGTGGA 5 -- ds50010--------
    rs1850198491,2
    --85109051(+) GTCTCC/TTTCAG 5 -- ds50010--------
    rs1492513211,2
    --85109256(+) ATACTC/GTATAT 5 -- ds50010--------
    rs1470633871,2
    C--85109333(+) AGAAA-/GAGGAGTT 5 -- ds50010--------
    rs1438014571,2
    --85109364(+) ACTTAC/TAGTCC 5 -- ds50010--------
    rs1883096071,2
    --85109366(+) TTATAA/GTCCAT 5 -- ds50010--------
    rs1931932401,2
    --85109453(+) CTAGGC/TACATG 5 -- ut310--------

    HapMap Linkage Disequilibrium report for SSX2IP (85109390 - 85156486 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SSX2IP: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SSX2IP
    DNA2.0 Custom Variant and Variant Library Synthesis for SSX2IP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608690    OMIM disorders: --

    3 diseases for SSX2IP:    
    About MalaCards
    constrictive pericarditis    synovial sarcoma    sarcoma

    1 disease from the University of Copenhagen DISEASES database for SSX2IP:
    Constrictive pericarditis

    Find genes that share disorders with SSX2IP           About GenesLikeMe

    Genetic Association Database (GAD): SSX2IP

    Export disorders for SSX2IP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SSX2IP gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with SSX2IP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PubMed id 12007189)1, 2, 9 de Bruijn D.R.H....van Kessel A.G. (Genes Chromosomes Cancer 2002)
    2. Elevated expression of the leukemia-associated antigen SSX2IP predicts survival in acute myeloid leukemia patients who lack detectable cytogenetic rearrangements. (PubMed id 19179477)1, 2 Guinn B....Mills K.I. (Blood 2009)
    3. The leukaemia-associated antigen, SSX2IP, is expressed during mitosis on the surface of myeloid leukaemia cells. (PubMed id 17686061)1, 2 Denniss F.A....Guinn B.A. (Br. J. Haematol. 2007)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    7. SSX2IP: an emerging role in cancer. (PubMed id 17904521)1, 9 Breslin A....Guinn B.A. (Biochem. Biophys. Res. Commun. 2007)
    8. Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia. (PubMed id 16112646)1, 9 Guinn B.-A.... Mufti G.J. (Biochem. Biophys. Res. Commun. 2005)
    9. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    10. SSX2IP promotes metastasis and chemotherapeutic resistance of hepatocellular carcinoma. (PubMed id 23452395)1 Li P....Huo K. (J Transl Med 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 117178 HGNC: 16509 AceView: SSX2IP Ensembl:ENSG00000117155 euGenes: HUgn117178
    ECgene: SSX2IP Kegg: 117178 H-InvDB: SSX2IP

    (According to HUGE)
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    HUGE: KIAA0923

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SSX2IP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SSX2IP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SSX2IP gene:
    Search GeneIP for patents involving SSX2IP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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