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Set Analyses:

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SSX2IP Gene

protein-coding GIFtS: 57
GCID: GC01M085109

Synovial Sarcoma, X Breakpoint 2 Interacting Protein

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Synovial Sarcoma, X Breakpoint 2 Interacting Protein¹ ²
Afadin DIL Domain-Interacting Protein² ³
ADIP² ³
SSX2-Interacting Protein² ³
Afadin- And Alpha-Actinin-Binding Protein²
KIAA0923³

External Ids:	HGNC: 16509¹	Entrez Gene: 117178²	Ensembl: ENSG00000117155⁷	OMIM: 608690⁵	UniProtKB: Q9Y2D8³

Export aliases for SSX2IP gene to outside databases

Previous GC identifers: GC00U991126 GC01M084247 GC01M084397 GC01M084531 GC01M084532 GC01M084821 GC01M084881 GC01M083219

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SSX2IP Gene:

This gene encodes a protein that binds the cancer-testis antigen Synovial Sarcoma X breakpoint 2 protein. The

encoded protein may regulate the activity of Synovial Sarcoma X breakpoint 2 protein in malignant cells.

Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3.

(provided by RefSeq, Oct 2009)

GeneCards Summary for SSX2IP Gene:

SSX2IP (synovial sarcoma, X breakpoint 2 interacting protein) is a protein-coding gene. Diseases associated with SSX2IP include constrictive pericarditis, and synovial sarcoma. GO annotations related to this gene include protein domain specific binding.

UniProtKB/Swiss-Prot: ADIP_HUMAN, Q9Y2D8

Function: Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and

heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system

through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and

alpha-actinin. Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and

is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of

Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of

the pericentriolar material and proper microtubule nucleation at mitotic spindle poles

Gene Wiki entry for SSX2IP Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000001.11 NT_032977.10 NC_018912.2

Regulatory elements:

Regulatory transcription factor binding sites in the SSX2IP gene promoter:
GATA-3 Bach2 ATF-2 POU3F2 (N-Oct-5a) POU3F2 GATA-2 Evi-1 S8 NF-Y CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SSX2IP promoter sequence

Search Chromatin IP Primers for SSX2IP

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SSX2IP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.3 Ensembl cytogenetic band: 1p22.3 HGNC cytogenetic band: 1p22.3

SSX2IP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSX2IP gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M085109: view genomic region (about GC identifiers)

Start:	85,109,390 bp from pter	End:	85,156,486 bp from pter
Size:	47,097 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ADIP_HUMAN, Q9Y2D8 (See protein sequence)

Recommended Name: Afadin- and alpha-actinin-binding protein

Size: 614 amino acids; 71236 Da

Subunit: Interacts with afadin and alpha-actinin. Interacts with VAV2 (By similarity). Interacts with SSX2 and

SSX3. Does not interact with SSX1 and SSX4

Developmental stage: Expressed in interphase and M phase cells. Down-regulated by the miRNA miR338-3p

Miscellaneous: Acts as an acute myeloid leukemia-associated antigen and may be used as a potential immunotherapy

target for leukemia (PubMed:17686061, PubMed:19179477)

Sequence caution: Sequence=BAA76767.2; Type=Erroneous initiation;

Secondary accessions: A8K8W0 B4DFE3 D3DT13 J3KR02 Q6P2P8 Q6ULS1 Q7L168 Q9UIX0

Alternative splicing: 3 isoforms: Q9Y2D8-1 Q9Y2D8-2 Q9Y2D8-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SSX2IP: NX_Q9Y2D8

Explore proteomics data for SSX2IP at MOPED

Post-translational modifications:

Ubiquitination² at Lys112, Lys476, Lys535

Modification sites at PhosphoSitePlus

See SSX2IP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (5 alternative transcripts):

NP_001159765.1 NP_001159766.1 NP_001159767.1 NP_001159889.1 NP_054740.3

ENSEMBL proteins:

ENSP00000340279 ENSP00000432261 ENSP00000474925 ENSP00000474480 ENSP00000473763

ENSP00000416067 ENSP00000412781 ENSP00000359644

SSX2IP Human Recombinant Protein Products:

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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for SSX2IP OriGene Custom MassSpec OriGene Custom Protein Services for SSX2IP
	GenScript Custom Purified and Recombinant Proteins Services for SSX2IP
	Novus Biologicals SSX2IP Protein Novus Biologicals SSX2IP Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

SSX2IP Antibody Products:

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	Novus Biologicals SSX2IP Antibodies
	Abcam antibodies for SSX2IP
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for SSX2IP
	LSBio Antibodies in human, mouse, rat for SSX2IP

SSX2IP Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for SSX2IP
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SSX2IP
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:

IPR021622 Afadin/alpha-actinin-bd

Graphical View of Domain Structure for InterPro Entry Q9Y2D8

ProtoNet protein and cluster: Q9Y2D8

UniProtKB/Swiss-Prot: ADIP_HUMAN, Q9Y2D8

Domain: Both the N-terminal (up to position 79) and the C-terminal (from position 304) sequences are required for

interaction with SSX2

Similarity: Belongs to the ADIP family

SSX2IP for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: ADIP_HUMAN, Q9Y2D8

Function: Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and

heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system

through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and

alpha-actinin. Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and

is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of

Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of

the pericentriolar material and proper microtubule nucleation at mitotic spindle poles

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	12007189
GO:0019904	protein domain specific binding	IEA	--

SSX2IP for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SSX2IP

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SSX2IP

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SSX2IP

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SSX2IP

miRNA Products:		miRTarBase miRNAs that target SSX2IP: hsa-mir-92a-3p (MIRT049125), hsa-mir-193b-3p (MIRT016383), hsa-mir-339-5p (MIRT042758), hsa-mir-155-5p (MIRT020713)

		Block miRNA regulation of human, mouse, rat SSX2IP using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate SSX2IP (see all 102):
		hsa-miR-576-3p hsa-miR-3607-3p hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-4272 hsa-miR-106a hsa-miR-30d

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SSX2IP
		Predesigned siRNA for gene silencing in human, mouse, rat SSX2IP

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SSX2IP

Clone Products:		OriGene clones in human, mouse for SSX2IP (see all 26) OriGene ORF clones in mouse, rat for SSX2IP OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): SSX2IP (NM_014021)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSX2IP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSX2IP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SSX2IP
		Browse ESI BIO Cell Lines and PureStem Progenitors for SSX2IP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSX2IP

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

ADIP_HUMAN, Q9Y2D8: Cell junction, adherens junction (By similarity). Nucleus. Cytoplasm, cytoskeleton,

microtubule organizing center, centrosome, centriolar satellite. Note=Not found at cell-matrix AJs (By

similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
cytosol	2
cytoskeleton	1

About this image

Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005913	cell-cell adherens junction	IEA	--
GO:0031252	cell leading edge	IEA	--
GO:0034451	centriolar satellite	IDA	--
GO:0043234	protein complex	IDA	--

SSX2IP for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SSX2IP About

See pathways by source

SuperPath

Contained pathways About

PAK Pathway

Epithelial Adherens Junctions

0.36

Adherens junction

Adherens junction

Pathways by source See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SSX2IP

Epithelial Adherens Junctions

1 Kegg Pathway (Kegg details for SSX2IP):

Adherens junction

SSX2IP for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Array including SSX2IP:

Adherens Junctions in human mouse rat

Interactions:

GeneGlobe Interaction Network for SSX2IP

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

Selected Interacting proteins for SSX2IP (Q9Y2D8^{1, 2, 3} ENSP00000340279⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SSX2	Q16385¹^,³, ENSP00000338796⁴	EBI-2212028,EBI-2210673 I2D: score=2 STRING: ENSP00000338796
SSX2B	Q16385¹^,³	EBI-2212028,EBI-2210673 I2D: score=2
ACTN2	P35609³, ENSP00000355537⁴	I2D: score=1 STRING: ENSP00000355537
SSX3	Q99909³, ENSP00000298396⁴	I2D: score=1 STRING: ENSP00000298396
USP11	P51784³, ENSP00000218348⁴	I2D: score=2 STRING: ENSP00000218348

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Gene Ontology (GO): 4 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	IEA	--
GO:0035020	regulation of Rac protein signal transduction	IEA	--
GO:0051297	centrosome organization	IMP	--
GO:2000145	regulation of cell motility	IEA	--

SSX2IP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for SSX2IP (ADIP)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SSX2IP gene (5 alternative transcripts):

NM_001166293.1 NM_001166294.1 NM_001166295.1 NM_001166417.1 NM_014021.3

Unigene Cluster for SSX2IP:

Synovial sarcoma, X breakpoint 2 interacting protein

Hs.22587 [show with all ESTs]

Unigene Representative Sequence: NM_001166417

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000342203(uc001dkf.3 uc001dki.3 uc010osa.2 uc001dkj.3)

ENST00000481102(uc009wci.3) ENST00000476905(uc001dkk.1) ENST00000605755

ENST00000603677 ENST00000490476 ENST00000459708 ENST00000460500 ENST00000422026

ENST00000437941(uc001dkh.3 uc010orz.2 uc001dkg.3) ENST00000370612

miRNA Products:		Block miRNA regulation of human, mouse, rat SSX2IP using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate SSX2IP (see all 102):
		hsa-miR-576-3p hsa-miR-3607-3p hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-4272 hsa-miR-106a hsa-miR-30d

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SSX2IP
		Predesigned siRNA for gene silencing in human, mouse, rat SSX2IP

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		GenScript: all cDNA clones in your preferred vector (see all 5): SSX2IP (NM_014021)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSX2IP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSX2IP

Primer Products:		OriGene qPCR primer pairs and template standards for SSX2IP OriGene qSTAR qPCR primer pairs in human, mouse for SSX2IP
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat SSX2IP
		QuantiTect SYBR Green Assays in human, mouse, rat SSX2IP
		QuantiFast Probe-based Assays in human, mouse, rat SSX2IP

Additional mRNA sequence:

AB023140.1 AK001710.1 AK021515.1 AK023097.1 AK292475.1 AK294057.1 AK307336.1 AK316472.1

AL133046.1 AY367055.1 AY651262.1 BC033637.1 BC035580.1 BC064389.1

12 DOTS entries:

DT.443120 DT.91724867 DT.95364110 DT.91819070 DT.87046250 DT.100027963 DT.97818472 DT.95148373

DT.95364109 DT.121357808 DT.40124571 DT.100793289

Selected AceView cDNA sequences (see all 226):

AU133150 BC064389 BU631256 CA415280 BU618267 AI565298 Z45825 BU633035

BM721181 BQ424849 BU742907 BG291491 CA446442 AI375402 AA721219 AI421459

AL133046 AI274784 BE465593 BI520350 CR613292 BF195136 AW593744 AI453170

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for SSX2IP (see all 7) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15a	·	15b
SP1:			-																																-		-
SP2:																													-						-
SP3:																													-						-		-
SP4:																													-						-		-
SP5:

ECgene alternative splicing isoforms for SSX2IP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SSX2IP expression in normal human tissues (normalized intensities) SSX2IP embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CACTCACCCT

About this image

SSX2IP expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 2) fully expand


Testis (Reproductive System) fully expand to see all 3 entries
Leydig Cells Testis Interstitium
Testis Interstitium

Blood (Hematopoietic System)
Proerythroblasts Hematopoietic Bone Marrow

SSX2IP Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

SSX2IP Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.22587

UniProtKB/Swiss-Prot: ADIP_HUMAN, Q9Y2D8

Tissue specificity: Widely expressed, with the highest expression in brain, intermediate expression in kidney,

testis, spinal cord, liver, heart, lung, skeletal muscle, ovary, fetal liver and fetal brain, and little to no

expression in pancreas and spleen. All specific brain regions showed intermediate to high expression, with

highest expression in amygdala. Also expressed in fetal tissues, mainly in liver and brain

Pathway & Disease-focused RT² Profiler PCR Array including SSX2IP:

Adherens Junctions in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for SSX2IP OriGene qSTAR qPCR primer pairs in human, mouse for SSX2IP
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat SSX2IP
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		QuantiFast Probe-based Assays in human, mouse, rat SSX2IP

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSX2IP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for SSX2IP gene from Selected species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ssx2ip^{1 , 5}	synovial sarcoma, X breakpoint 2 interacting protein^{1, 5}	84.15(n)¹ 87.62(a)¹		3 (71.03 cM)⁵ 99167¹ NM_138744.3¹ NP_620083.1¹ 146404642⁵
chicken (Gallus gallus)	Aves	SSX2IP¹	synovial sarcoma, X breakpoint 2 interacting protein	75.76(n) 75.27(a)		424532 NM_001044656.1 NP_001038121.1
lizard (Anolis carolinensis)	Reptilia	SSX2IP⁶	synovial sarcoma, X breakpoint 2 interacting prote...	69(a)	1 ↔ 1	GL343194.1(9853238-9888522)
African clawed frog (Xenopus laevis)	Amphibia	BU914026.1²	--	75.79(n)		BU914026.1
zebrafish (Danio rerio)	Actinopterygii	zgc73314²	hypothetical protein MGC73314	72.7(n)		393808 BC060934.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G18876¹	AT2G18876	46.96(n) 32(a)		816403 NM_179650.1 NP_849981.1
rice (Oryza sativa)	Liliopsida	Os08g0242900¹	Os08g0242900	44.68(n) 29.82(a)		4345045 NM_001067879.1 NP_001061344.1

ENSEMBL Gene Tree for SSX2IP (if available)
TreeFam Gene Tree for SSX2IP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for SSX2IP gene

SSX2IP for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SSX2IP
PGOHUM00000237700

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10874454^1,2	C,F,A,H	--	85108904(+)	`CAGCAG/ATAAAC`	5	--	ds500¹		14		NS EA NA WA	724
rs192426961^1,2		--	85108971(+)	`AGATTG/TTAAGT`	5	--	ds500¹		0	--	--	--	--
rs145755469^1,2		--	85108975(+)	`TGTAAC/GTGCTC`	5	--	ds500¹		0	--	--	--	--
rs138357268^1,2		--	85109034(+)	`CTGTAA/GGTGGA`	5	--	ds500¹		0	--	--	--	--
rs185019849^1,2		--	85109051(+)	`GTCTCC/TTTCAG`	5	--	ds500¹		0	--	--	--	--
rs149251321^1,2		--	85109256(+)	`ATACTC/GTATAT`	5	--	ds500¹		0	--	--	--	--
rs147063387^1,2	C	--	85109333(+)	`AGAAA-/GAGGAGTT`	5	--	ds500¹		0	--	--	--	--
rs143801457^1,2		--	85109364(+)	`ACTTAC/TAGTCC`	5	--	ds500¹		0	--	--	--	--
rs188309607^1,2		--	85109366(+)	`TTATAA/GTCCAT`	5	--	ds500¹		0	--	--	--	--
rs193193240^1,2		--	85109453(+)	`CTAGGC/TACATG`	5	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SSX2IP (85109390 - 85156486 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for SSX2IP: --

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608690 OMIM disorders: --

9 diseases for SSX2IP: About MalaCards

constrictive pericarditis synovial sarcoma pericarditis sarcoma

acute myeloid leukemia myeloid leukemia type 1 diabetes leukemia

hepatocellular carcinoma

1 disease from the University of Copenhagen DISEASES database for SSX2IP:

Constrictive pericarditis

SSX2IP for disorders About GeneDecksing

Genetic Association Database (GAD): SSX2IP

Export disorders for SSX2IP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SSX2IP gene, integrated from 10 sources (see all 37):
(articles sorted by number of sources associating them with SSX2IP)

Utopia: connect your pdf to the dynamic
world of online information

The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PubMed id 12007189)^{1, 2, 9} de Bruijn D.R.H....van Kessel A.G. (Genes Chromosomes Cancer 2002)
Elevated expression of the leukemia-associated antigen SSX2IP predicts survival in acute myeloid leukemia patients who lack detectable cytogenetic rearrangements. (PubMed id 19179477)^{1, 2} Guinn B....Mills K.I. (Blood 2009)
The leukaemia-associated antigen, SSX2IP, is expressed during mitosis on the surface of myeloid leukaemia cells. (PubMed id 17686061)^{1, 2} Denniss F.A....Guinn B.A. (Br. J. Haematol. 2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)^{1, 2} Nagase T.... Ohara O. (DNA Res. 1999)
SSX2IP: an emerging role in cancer. (PubMed id 17904521)^{1, 9} Breslin A....Guinn B.A. (Biochem. Biophys. Res. Commun. 2007)
Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia. (PubMed id 16112646)^{1, 9} Guinn B.-A.... Mufti G.J. (Biochem. Biophys. Res. Commun. 2005)
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)¹ Couzens A.L....Gingras A.C. (Sci Signal 2013)
SSX2IP promotes metastasis and chemotherapeutic resistance of hepatocellular carcinoma. (PubMed id 23452395)¹ Li P....Huo K. (J Transl Med 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 117178	HGNC: 16509	AceView: SSX2IP	Ensembl:ENSG00000117155	euGenes: HUgn117178
ECgene: SSX2IP	Kegg: 117178	H-InvDB: SSX2IP

(According to HUGE)
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HUGE: KIAA0923

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SSX2IP	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SSX2IP	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SSX2IP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SSX2IP gene:
Search GeneIP for patents involving SSX2IP

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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SSX2IP Gene

Synovial Sarcoma, X Breakpoint 2 Interacting Protein

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SSX2IP Gene

Synovial Sarcoma, X Breakpoint 2 Interacting Protein

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