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Aliases for SSX2IP Gene

Aliases for SSX2IP Gene

  • Synovial Sarcoma, X Breakpoint 2 Interacting Protein 2 3
  • Afadin DIL Domain-Interacting Protein 3 4
  • SSX2-Interacting Protein 3 4
  • ADIP 3 4
  • Afadin- And Alpha-Actinin-Binding Protein 3
  • KIAA0923 4

External Ids for SSX2IP Gene

Previous GeneCards Identifiers for SSX2IP Gene

  • GC00U991126
  • GC01M084247
  • GC01M084397
  • GC01M084531
  • GC01M084532
  • GC01M084821
  • GC01M084881
  • GC01M085109
  • GC01M083219

Summaries for SSX2IP Gene

Entrez Gene Summary for SSX2IP Gene

  • This gene encodes a protein that binds the cancer-testis antigen Synovial Sarcoma X breakpoint 2 protein. The encoded protein may regulate the activity of Synovial Sarcoma X breakpoint 2 protein in malignant cells. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Oct 2009]

GeneCards Summary for SSX2IP Gene

SSX2IP (Synovial Sarcoma, X Breakpoint 2 Interacting Protein) is a Protein Coding gene. Diseases associated with SSX2IP include constrictive pericarditis and sarcoma. Among its related pathways are PAK Pathway and Adherens junction. GO annotations related to this gene include protein domain specific binding.

UniProtKB/Swiss-Prot for SSX2IP Gene

  • Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles (PubMed:23816619). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitement of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449).

Gene Wiki entry for SSX2IP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSX2IP Gene

Genomics for SSX2IP Gene

Regulatory Elements for SSX2IP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SSX2IP Gene

Start:
84,643,707 bp from pter
End:
84,690,803 bp from pter
Size:
47,097 bases
Orientation:
Minus strand

Genomic View for SSX2IP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSX2IP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSX2IP Gene

Proteins for SSX2IP Gene

  • Protein details for SSX2IP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2D8-ADIP_HUMAN
    Recommended name:
    Afadin- and alpha-actinin-binding protein
    Protein Accession:
    Q9Y2D8
    Secondary Accessions:
    • A8K8W0
    • B4DFE3
    • D3DT13
    • J3KR02
    • Q6P2P8
    • Q6ULS1
    • Q7L168
    • Q9UIX0

    Protein attributes for SSX2IP Gene

    Size:
    614 amino acids
    Molecular mass:
    71236 Da
    Quaternary structure:
    • Interacts with afadin and alpha-actinin (By similarity). Interacts with VAV2 (By similarity). Interacts with SSX2 and SSX3. Does not interact with SSX1 and SSX4. Interacts with PCM1 (By similarity).
    Miscellaneous:
    • Acts as an acute myeloid leukemia-associated antigen and may be used as a potential immunotherapy target for leukemia (PubMed:17686061, PubMed:19179477).
    SequenceCaution:
    • Sequence=BAA76767.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SSX2IP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSX2IP Gene

Proteomics data for SSX2IP Gene at MOPED

Post-translational modifications for SSX2IP Gene

  • Ubiquitination at Lys112, Lys476, and Lys535
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SSX2IP Gene

Domains for SSX2IP Gene

Protein Domains for SSX2IP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SSX2IP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2D8

UniProtKB/Swiss-Prot:

ADIP_HUMAN :
  • Q9Y2D8
Domain:
  • Both the N-terminal (up to position 79) and the C-terminal (from position 304) sequences are required for interaction with SSX2
Family:
  • Belongs to the ADIP family.
genes like me logo Genes that share domains with SSX2IP: view

No data available for Gene Families for SSX2IP Gene

Function for SSX2IP Gene

Molecular function for SSX2IP Gene

UniProtKB/Swiss-Prot Function: Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles (PubMed:23816619). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitement of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449).

Gene Ontology (GO) - Molecular Function for SSX2IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12007189
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with SSX2IP: view

Animal Model Products

CRISPR Products

miRNA for SSX2IP Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSX2IP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SSX2IP Gene

Localization for SSX2IP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSX2IP Gene

Cell junction, adherens junction. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body. Note=Not found at cell-matrix AJs. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSX2IP Gene COMPARTMENTS Subcellular localization image for SSX2IP gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SSX2IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005913 cell-cell adherens junction IEA --
GO:0031252 cell leading edge IEA --
GO:0034451 centriolar satellite IDA 23816619
GO:0036064 ciliary basal body IDA 24356449
genes like me logo Genes that share ontologies with SSX2IP: view

Pathways for SSX2IP Gene

genes like me logo Genes that share pathways with SSX2IP: view

Pathways by source for SSX2IP Gene

1 Qiagen pathway for SSX2IP Gene
1 KEGG pathway for SSX2IP Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SSX2IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0035020 regulation of Rac protein signal transduction IEA --
GO:0035735 intraciliary transport involved in cilium morphogenesis IMP 24356449
GO:0042384 cilium assembly IMP 24356449
GO:0051297 centrosome organization IMP 23816619
genes like me logo Genes that share ontologies with SSX2IP: view

Transcripts for SSX2IP Gene

Unigene Clusters for SSX2IP Gene

Synovial sarcoma, X breakpoint 2 interacting protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSX2IP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSX2IP Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - -
SP5:
SP6: -
SP7:

Relevant External Links for SSX2IP Gene

GeneLoc Exon Structure for
SSX2IP
ECgene alternative splicing isoforms for
SSX2IP

Expression for SSX2IP Gene

mRNA expression in normal human tissues for SSX2IP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SSX2IP Gene

This gene is overexpressed in Testis (5.3) and Brain - Frontal Cortex (BA9) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSX2IP Gene

SOURCE GeneReport for Unigene cluster for SSX2IP Gene Hs.22587

mRNA Expression by UniProt/SwissProt for SSX2IP Gene

Q9Y2D8-ADIP_HUMAN
Tissue specificity: Widely expressed, with the highest expression in brain, intermediate expression in kidney, testis, spinal cord, liver, heart, lung, skeletal muscle, ovary, fetal liver and fetal brain, and little to no expression in pancreas and spleen. All specific brain regions showed intermediate to high expression, with highest expression in amygdala. Also expressed in fetal tissues, mainly in liver and brain
genes like me logo Genes that share expressions with SSX2IP: view

In Situ Assay Products

Orthologs for SSX2IP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SSX2IP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSX2IP 35
  • 99.62 (n)
  • 99.67 (a)
SSX2IP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SSX2IP 35
  • 92.89 (n)
  • 94.95 (a)
SSX2IP 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSX2IP 35
  • 92.78 (n)
  • 94.95 (a)
SSX2IP 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ssx2ip 35
  • 84.15 (n)
  • 87.62 (a)
Ssx2ip 16
Ssx2ip 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SSX2IP 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSX2IP 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ssx2ip 35
  • 83.88 (n)
  • 87.42 (a)
chicken
(Gallus gallus)
Aves SSX2IP 35
  • 75.76 (n)
  • 75.27 (a)
SSX2IP 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSX2IP 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ssx2ip 35
  • 62.96 (n)
  • 61.32 (a)
Str.8904 35
zebrafish
(Danio rerio)
Actinopterygii LOC100534665 35
  • 59.68 (n)
  • 58.41 (a)
ssx2ip 36
  • 50 (a)
OneToMany
SSX2IP (2 of 3) 36
  • 51 (a)
OneToMany
SSX2IP (3 of 3) 36
  • 27 (a)
OneToMany
zgc73314 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G18876 35
  • 46.96 (n)
  • 32 (a)
rice
(Oryza sativa)
Liliopsida Os08g0242900 35
  • 44.68 (n)
  • 29.82 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToOne
Species with no ortholog for SSX2IP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSX2IP Gene

ENSEMBL:
Gene Tree for SSX2IP (if available)
TreeFam:
Gene Tree for SSX2IP (if available)

Paralogs for SSX2IP Gene

Pseudogenes.org Pseudogenes for SSX2IP Gene

genes like me logo Genes that share paralogs with SSX2IP: view

No data available for Paralogs for SSX2IP Gene

Variants for SSX2IP Gene

Sequence variations from dbSNP and Humsavar for SSX2IP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1927 -- 84,646,497(+) TTACT(A/G)TACTG utr-variant-3-prime
rs3782 -- 84,644,642(-) AGAGA(G/T)GTTTT utr-variant-3-prime
rs722789 -- 84,665,623(-) CTTTA(G/T)TGGTT intron-variant
rs1057746 - 84,647,546(-) GAGAA(C/T)GTACA missense, reference
rs1340523 -- 84,678,189(+) TATTA(C/T)GGTTA intron-variant

Relevant External Links for SSX2IP Gene

HapMap Linkage Disequilibrium report
SSX2IP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SSX2IP Gene

Disorders for SSX2IP Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SSX2IP Gene including...

Search for SSX2IP Gene in MalaCards »

(1) University of Copenhagen DISEASES for SSX2IP Gene

Relevant External Links for SSX2IP

Genetic Association Database (GAD)
SSX2IP
genes like me logo Genes that share disorders with SSX2IP: view

No data available for UniProtKB/Swiss-Prot for SSX2IP Gene

Publications for SSX2IP Gene

  1. The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PMID: 12007189) de Bruijn D.R.H. … van Kessel A.G. (Genes Chromosomes Cancer 2002) 3 4 23
  2. The leukaemia-associated antigen, SSX2IP, is expressed during mitosis on the surface of myeloid leukaemia cells. (PMID: 17686061) Denniss F.A. … Guinn B.A. (Br. J. Haematol. 2007) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia. (PMID: 16112646) Guinn B.-A. … Mufti G.J. (Biochem. Biophys. Res. Commun. 2005) 3 23

Products for SSX2IP Gene

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