Aliases for SSX2B Gene
External Ids for SSX2B Gene
Previous GeneCards Identifiers for SSX2B Gene
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 6757, located about 45 kb upstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013]
GeneCards Summary for SSX2B Gene
SSX2B (Synovial Sarcoma, X Breakpoint 2B) is a Protein Coding gene. Diseases associated with SSX2B include peroneal nerve paralysis and congenital mesoblastic nephroma. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is SSX2.
UniProtKB/Swiss-Prot for SSX2B Gene
Could act as a modulator of transcription