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Aliases for SSX2B Gene

Aliases for SSX2B Gene

  • Synovial Sarcoma, X Breakpoint 2B 2 3
  • Cancer/Testis Antigen 5.2 3 4
  • Tumor Antigen HOM-MEL-40 3 4
  • CT5.2 3 4
  • Cancer/Testis Antigen Family 5, Member 2b 3
  • Synovial Sarcoma, X Breakpoint 2 4
  • Cancer/Testis Antigen Family 5 2
  • Protein SSX2 3
  • HOM-MEL-40 3
  • SSX2 SSX2B 4
  • Member 2b 2
  • CT5.2b 3
  • SSX2A 4
  • SSX 3

External Ids for SSX2B Gene

Previous GeneCards Identifiers for SSX2B Gene

  • GC0XP052797

Summaries for SSX2B Gene

Entrez Gene Summary for SSX2B Gene

  • The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 6757, located about 45 kb upstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013]

GeneCards Summary for SSX2B Gene

SSX2B (Synovial Sarcoma, X Breakpoint 2B) is a Protein Coding gene. Diseases associated with SSX2B include peroneal nerve paralysis and congenital mesoblastic nephroma. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is SSX2.

UniProtKB/Swiss-Prot for SSX2B Gene

  • Could act as a modulator of transcription

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSX2B Gene

Genomics for SSX2B Gene

Regulatory Elements for SSX2B Gene

Genomic Location for SSX2B Gene

52,751,132 bp from pter
52,790,305 bp from pter
39,174 bases
Plus strand

Genomic View for SSX2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSX2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSX2B Gene

Proteins for SSX2B Gene

  • Protein details for SSX2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein SSX2
    Protein Accession:
    Secondary Accessions:
    • Q16404
    • Q5JS26
    • Q96IP7
    • Q9BU88

    Protein attributes for SSX2B Gene

    188 amino acids
    Molecular mass:
    21620 Da
    Quaternary structure:
    • Interacts via its N-terminal region with RAB3IP and SSX2IP.
    • Sequence=AAB35674.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SSX2B Gene


neXtProt entry for SSX2B Gene

Proteomics data for SSX2B Gene at MOPED

Post-translational modifications for SSX2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SSX2B Gene

No data available for DME Specific Peptides for SSX2B Gene

Domains for SSX2B Gene

Protein Domains for SSX2B Gene

Suggested Antigen Peptide Sequences for SSX2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB-related domain.
  • Belongs to the SSX family.
  • Contains 1 KRAB-related domain.
  • Belongs to the SSX family.
genes like me logo Genes that share domains with SSX2B: view

No data available for Gene Families for SSX2B Gene

Function for SSX2B Gene

Molecular function for SSX2B Gene

UniProtKB/Swiss-Prot Function:
Could act as a modulator of transcription

Gene Ontology (GO) - Molecular Function for SSX2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 12007189
genes like me logo Genes that share ontologies with SSX2B: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSX2B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SSX2B Gene

Localization for SSX2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSX2B Gene

Subcellular locations from

Jensen Localization Image for SSX2B Gene COMPARTMENTS Subcellular localization image for SSX2B gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SSX2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with SSX2B: view

Pathways for SSX2B Gene

genes like me logo Genes that share pathways with SSX2B: view

Pathways by source for SSX2B Gene

1 KEGG pathway for SSX2B Gene

Gene Ontology (GO) - Biological Process for SSX2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 7539744
genes like me logo Genes that share ontologies with SSX2B: view

Transcripts for SSX2B Gene

mRNA/cDNA for SSX2B Gene

(3) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSX2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSX2B Gene

No ASD Table

Relevant External Links for SSX2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SSX2B Gene

mRNA expression in normal human tissues for SSX2B Gene

mRNA differential expression in normal tissues according to GTEx for SSX2B Gene

This gene is overexpressed in Testis (51.9).

Protein differential expression in normal tissues for SSX2B Gene

This gene is overexpressed in Testis (48.3) and Ovary (20.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SSX2B Gene

mRNA Expression by UniProt/SwissProt for SSX2B Gene

Tissue specificity: Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and fibrosarcoma cell lines. Not detected in mesenchymal and epithelial cell lines
genes like me logo Genes that share expressions with SSX2B: view

Expression partners for SSX2B Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SSX2B Gene

Orthologs for SSX2B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SSX2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100609340 35
  • 98.94 (n)
  • 98.4 (a)
Species with no ortholog for SSX2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SSX2B Gene

Gene Tree for SSX2B (if available)
Gene Tree for SSX2B (if available)

Paralogs for SSX2B Gene

Paralogs for SSX2B Gene

(14) SIMAP similar genes for SSX2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SSX2B: view

Variants for SSX2B Gene

Sequence variations from dbSNP and Humsavar for SSX2B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs5943733 -- 52,755,110(-) AACCT(A/G)TCTTT intron-variant
rs55994523 -- 52,757,188(+) AAAAA(-/A)GAAAG intron-variant
rs57223020 -- 52,753,649(+) TTTTT(-/TT)GAGTC intron-variant
rs111728628 -- 52,759,783(+) GCATG(A/C)CTGTA intron-variant
rs112024130 -- 52,751,209(+) GGATT(C/G)GCTAC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SSX2B Gene

Variant ID Type Subtype PubMed ID
esv2740170 CNV Deletion 23290073
esv21492 CNV Gain 19812545
nsv7446 OTHER Inversion 18451855

Relevant External Links for SSX2B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSX2B Gene

Disorders for SSX2B Gene


  • Note=A chromosomal aberration involving SSX2 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).

(3) University of Copenhagen DISEASES for SSX2B Gene

genes like me logo Genes that share disorders with SSX2B: view

No data available for OMIM , Novoseek inferred disease relationships , Genatlas and External Links for SSX2B Gene

Publications for SSX2B Gene

  1. Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript. (PMID: 7495284) Fligman I. … Ladanyi M. (Am. J. Pathol. 1995) 3 4
  2. Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. (PMID: 7539744) Crew A.J. … Cooper C.S. (EMBO J. 1995) 3 4
  3. Identification of two alternative fusion genes, SYT-SSX1 and SYT- SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas. (PMID: 7655467) de Leeuw B. … Geurts van Kessel A. (Hum. Mol. Genet. 1995) 3 4
  4. Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. (PMID: 7951320) Clark J. … Cooper C.S. (Nat. Genet. 1994) 3 4
  5. The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PMID: 12007189) de Bruijn D.R.H. … van Kessel A.G. (Genes Chromosomes Cancer 2002) 3 4

Products for SSX2B Gene

Sources for SSX2B Gene

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