SSX2B Gene
protein-coding GIFtS: 34
GCID: GC0XP052797
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synovial sarcoma, X breakpoint 2B
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Aliases
for SSX2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Synovial Sarcoma, X Breakpoint 2B1 2 | | SSX2 | | CT5.2b1 2 | | Cancer/Testis Antigen Family 5, Member 2b2 | | Cancer/Testis Antigen 5.22 3 | | Protein SSX22 | | Tumor Antigen HOM-MEL-402 3 | | SSX2A3 | | CT5.22 3 | | Synovial Sarcoma, X Breakpoint 23 | | HOM-MEL-402 | | |
Export aliases for SSX2B gene to outside databases |
Summaries
for SSX2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SSX2_HUMAN, Q16385Function: Could act as a modulator of transcription
|
Genomic Views
for SSX2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SSX2B gene promoter:
NCX/Ncx CUTL1 LCR-F1 HNF-1A C/EBPalpha PPAR-gamma1 HNF-1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SSX2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSX2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.22 Ensembl cytogenetic band: Xp11.22 HGNC cytogenetic band: Xp11.22SSX2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP052797: view genomic region
(about GC identifiers)
Start:
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52,780,308 bp from pter |
End:
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52,790,617 bp from pter |
Size:
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10,310 bases |
Orientation:
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plus strand |
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Proteins
for SSX2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SSX2_HUMAN, Q16385 (See
protein sequence)Recommended Name: Protein SSX2 Size: 188 amino acids; 21620 Da
Subunit: Interacts via its N-terminal region with RAB3IP and SSX2IP
Subcellular location: Nucleus
Sequence caution: Sequence=AAB35674.1; Type=Erroneous initiation;
Secondary accessions: Q16404 Q5JS26 Q96IP7 Q9BU88Alternative splicing: 2 isoforms: Q16385-1 Q16385-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SSX2B: NX_Q16385
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q16385
SSX2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001157889.1
ENSEMBL proteins: ENSP00000364665 ENSP00000276049
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IDA | -- |
SSX2B for ontologies About GeneDecksing
SSX2B Antibody Products:
Assay Products for SSX2B: |
Protein
Domains /
Families
for SSX2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SSX2B for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q16385ProtoNet protein and cluster: Q16385 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: SSX2_HUMAN, Q16385Similarity: Belongs to the SSX familySimilarity: Contains 1 KRAB-related domain |
Function
for SSX2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SSX2_HUMAN, Q16385Function: Could act as a modulator of transcription
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSX2B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSX2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SSX2B (NM_001164417) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SSX2B | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SSX2B |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SSX2B for ontologies About GeneDecksing
|
Pathways & Interactions
for SSX2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SSX2B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)
5/28 Interacting proteins for SSX2B (Q163851, 3 ENSP000003646654) via UniProtKB, MINT, STRING, and/or I2D (see all 28)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
NAS | 7539744 |
SSX2B for ontologies About GeneDecksing
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Drugs & Compounds
for SSX2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SSX2B
Search CenterWatch for drugs/clinical trials and news about SSX2B / SSX2
|
Transcripts
for SSX2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SSX2B gene: NM_001164417.1 3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000375515(uc004drb.1) ENST00000276049(uc004dra.1) ENST00000288839
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSX2B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSX2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SSX2B (NM_001164417) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SSX2B | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SSX2B |
GeneLoc Exon Structure
|
Expression
for SSX2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SSX2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SSX2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SSX2B
UniProtKB/Swiss-Prot: SSX2_HUMAN, Q16385Tissue specificity: Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in tonsil,colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and fibrosarcoma celllines. Not detected in mesenchymal and epithelial cell lines
SABiosciences Custom PCR Arrays for SSX2B
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SSX2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSX2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSX2B |
Orthologs
for SSX2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for SSX2B (if available)
TreeFam Gene Tree for SSX2B (if available) |
Paralogs
for SSX2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SSX2B gene
- SSX21 2 SSX62 SSX42 SSX72 SSX12 SSX52 SSX92 SSX4B2
- SSX32
15 SIMAP similar genes for SSX2B using alignment to 1 protein entry: SSX2_HUMAN:SSX10 SSX2 SSX3 SSX6 SSX5 SSX9
SSX7 SSX1 SSX8 SSX11 SSX4 SSX4B
SYT-SSX2 SYT-SSX1 SSX-HSTT
SSX2B for paralogs About GeneDecksing
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Genomic Variants
for SSX2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SSX2B (52780308 - 52790617 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for SSX2B
3 CNVs: 83527 73978 96690
1 Inversion: 37382 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for SSX2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SSX2B for disorders About GeneDecksing
UniProtKB/Swiss-Prot: SSX2_HUMAN, Q16385
Note=A chromosomal aberration involving SSX2 may be a cause of synovial sarcoma. Translocationt(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusionproducts SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position ofthe breakpoint can occur (low frequency)
14  diseases for SSX2B: About MalaCardssynovial sarcoma peroneal nerve paralysis congenital mesoblastic nephroma mesoblastic nephroma
sarcoma intrahepatic cholangiocarcinoma paralysis cholangiocarcinoma
tonsillitis fibrosarcoma rhabdomyosarcoma thyroiditis
melanoma prostatitis
2 diseases from the University of Copenhagen DISEASES database for SSX2B:Synovial sarcoma Peroneal nerve paralysis Export disorders for SSX2B gene to outside databases
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Publications
for SSX2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SSX2B gene integrated from 9 sources:
(articles sorted by number of sources associating them with SSX2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PubMed id 12007189)1, 2 de Bruijn D.R.H....van Kessel A.G. (2002)
- Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript. (PubMed id 7495284)1, 2 Fligman I....Ladanyi M. (1995)
- Identification of two alternative fusion genes, SYT-SSX1 and SYT- SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas. (PubMed id 7655467)1, 2 de Leeuw B.... Geurts van Kessel A. (1995)
- Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. (PubMed id 7539744)1, 2 Crew A.J.... Cooper C.S. (1995)
- Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. (PubMed id 7951320)1, 2 Clark J.... Cooper C.S. (1994)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
- Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (2000)
- Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines. (PubMed id 10749136)1 dos Santos N.R.... Geurts van Kessel A. (2000)
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External Searches for SSX2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SSX2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SSX2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SSX2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SSX2B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SSX2B gene:
Search GeneIP for patents involving SSX2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SSX2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SSX2B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSX2B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSX2B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSX2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSX2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSX2B |
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| | | | Search Tocris compounds for SSX2B |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for SSX2B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SSX2B |
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