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Aliases for SSX2 Gene

Aliases for SSX2 Gene

  • Synovial Sarcoma, X Breakpoint 2 2 3 4 5
  • Cancer/Testis Antigen 5.2 3 4
  • Tumor Antigen HOM-MEL-40 3 4
  • CT5.2 3 4
  • Cancer/Testis Antigen Family 5, Member 2a 3
  • Sarcoma, Synovial, X-Chromosome-Related 2 3
  • Synovial Sarcoma, X Breakpoint 2B 3
  • Cancer/Testis Antigen Family 5 2
  • X-Chromosome-Related 2 2
  • Synovial Sarcoma 2
  • X Breakpoint 2B 2
  • X Breakpoint 2 2
  • HOM-MEL-40 3
  • SSX2 SSX2B 4
  • Member 2a 2
  • Isoform B 2
  • Synovial 2
  • Sarcoma 2
  • CT5.2A 3
  • SSX2A 4
  • HD21 3
  • SSX 3

External Ids for SSX2 Gene

Previous HGNC Symbols for SSX2 Gene

  • SSX

Previous GeneCards Identifiers for SSX2 Gene

  • GC0XP043594
  • GC0XP050491
  • GC0XM051377
  • GC0XM051692
  • GC0XM052608
  • GC0XM052742
  • GC0XM052673
  • GC0XM049853
  • GC0XM052725

Summaries for SSX2 Gene

Entrez Gene Summary for SSX2 Gene

  • The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013]

GeneCards Summary for SSX2 Gene

SSX2 (Synovial Sarcoma, X Breakpoint 2) is a Protein Coding gene. Diseases associated with SSX2 include sarcoma, synovial and sarcoma. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is SSX3.

UniProtKB/Swiss-Prot for SSX2 Gene

  • Could act as a modulator of transcription.

Gene Wiki entry for SSX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSX2 Gene

Genomics for SSX2 Gene

Regulatory Elements for SSX2 Gene

Genomic Location for SSX2 Gene

Chromosome:
X
Start:
52,644,567 bp from pter
End:
52,707,227 bp from pter
Size:
62,661 bases
Orientation:
Minus strand

Genomic View for SSX2 Gene

Genes around SSX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSX2 Gene

Proteins for SSX2 Gene

  • Protein details for SSX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16385-SSX2_HUMAN
    Recommended name:
    Protein SSX2
    Protein Accession:
    Q16385
    Secondary Accessions:
    • Q16404
    • Q5JS26
    • Q96IP7
    • Q9BU88

    Protein attributes for SSX2 Gene

    Size:
    188 amino acids
    Molecular mass:
    21620 Da
    Quaternary structure:
    • Interacts via its N-terminal region with RAB3IP and SSX2IP.
    • Interacts via its N-terminal region with RAB3IP and SSX2IP.
    SequenceCaution:
    • Sequence=AAB35674.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SSX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSX2 Gene

Proteomics data for SSX2 Gene at MOPED

Post-translational modifications for SSX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SSX2 Gene

No data available for DME Specific Peptides for SSX2 Gene

Domains & Families for SSX2 Gene

Protein Domains for SSX2 Gene

Suggested Antigen Peptide Sequences for SSX2 Gene

Graphical View of Domain Structure for InterPro Entry

Q16385

UniProtKB/Swiss-Prot:

SSX2_HUMAN :
  • Contains 1 KRAB-related domain.
  • Belongs to the SSX family.
Domain:
  • Contains 1 KRAB-related domain.
Family:
  • Belongs to the SSX family.
genes like me logo Genes that share domains with SSX2: view

No data available for Gene Families for SSX2 Gene

Function for SSX2 Gene

Molecular function for SSX2 Gene

GENATLAS Biochemistry:
protein SSX2 with homology to Kruppel associated box,KRAB,transcriptional corepressor,complexing with polycomb group (PcG) proteins RING1 or BMI1 and associating with chromatin,fused with SYT (SSXT) in synovial sarcoma with translocation t(X;18)(p11.2;q11.2) (see BSSX)
UniProtKB/Swiss-Prot Function:
Could act as a modulator of transcription.

Gene Ontology (GO) - Molecular Function for SSX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with SSX2: view
genes like me logo Genes that share phenotypes with SSX2: view

Human Phenotype Ontology for SSX2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SSX2 Gene

Localization for SSX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSX2 Gene

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SSX2 Gene

Pathways & Interactions for SSX2 Gene

genes like me logo Genes that share pathways with SSX2: view

Pathways by source for SSX2 Gene

1 KEGG pathway for SSX2 Gene

Gene Ontology (GO) - Biological Process for SSX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903507 negative regulation of nucleic acid-templated transcription IBA --
genes like me logo Genes that share ontologies with SSX2: view

No data available for SIGNOR curated interactions for SSX2 Gene

Drugs & Compounds for SSX2 Gene

(1) Drugs for SSX2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for SSX2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SSX2: view

Transcripts for SSX2 Gene

Unigene Clusters for SSX2 Gene

Synovial sarcoma, X breakpoint 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSX2 Gene

No ASD Table

Relevant External Links for SSX2 Gene

GeneLoc Exon Structure for
SSX2
ECgene alternative splicing isoforms for
SSX2

Expression for SSX2 Gene

mRNA expression in normal human tissues for SSX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SSX2 Gene

This gene is overexpressed in Testis (x50.7).

Protein differential expression in normal tissues from HIPED for SSX2 Gene

This gene is overexpressed in Testis (48.3) and Ovary (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSX2 Gene



SOURCE GeneReport for Unigene cluster for SSX2 Gene Hs.289105

mRNA Expression by UniProt/SwissProt for SSX2 Gene

Q16385-SSX2_HUMAN
Tissue specificity: Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and fibrosarcoma cell lines. Not detected in mesenchymal and epithelial cell lines.
genes like me logo Genes that share expression patterns with SSX2: view

Protein tissue co-expression partners for SSX2 Gene

Primer Products

In Situ Assay Products

Orthologs for SSX2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SSX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100609340 35
  • 98.94 (n)
  • 98.4 (a)
-- 36
  • 69 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SSX5 36
  • 25 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 40 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm14459 36
  • 24 (a)
ManyToMany
Gm21876 36
  • 39 (a)
ManyToMany
Gm5751 36
  • 24 (a)
ManyToMany
Gm6592 36
  • 24 (a)
ManyToMany
Ssx9 36
  • 24 (a)
ManyToMany
Ssxa1 36
  • 35 (a)
ManyToMany
Ssxb1 36
  • 25 (a)
ManyToMany
Ssxb10 36
  • 25 (a)
ManyToMany
Ssxb2 36
  • 21 (a)
ManyToMany
Ssxb3 36
  • 24 (a)
ManyToMany
Ssxb5 36
  • 26 (a)
ManyToMany
Ssxb6 36
  • 28 (a)
ManyToMany
Ssxb8 36
  • 25 (a)
ManyToMany
Ssxb9 36
  • 24 (a)
ManyToMany
Species with no ortholog for SSX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SSX2 Gene

ENSEMBL:
Gene Tree for SSX2 (if available)
TreeFam:
Gene Tree for SSX2 (if available)

Paralogs for SSX2 Gene

Paralogs for SSX2 Gene

genes like me logo Genes that share paralogs with SSX2: view

Variants for SSX2 Gene

Sequence variations from dbSNP and Humsavar for SSX2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs4893641 -- 52,698,878(+) actgc(C/T)ccacc intron-variant, reference, missense
rs5943733 -- 52,703,320(-) AACCT(A/G)TCTTT intron-variant
rs57223020 -- 52,704,780(-) TTTTT(-/TT)GAGTC intron-variant
rs112553841 -- 52,698,505(+) CTATA(G/T)TGATC intron-variant
rs112024130 -- 52,707,221(-) GGATT(C/G)GCTAC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SSX2 Gene

Variant ID Type Subtype PubMed ID
esv2740170 CNV Deletion 23290073
esv21492 CNV Gain 19812545
nsv7446 OTHER Inversion 18451855

Relevant External Links for SSX2 Gene

HapMap Linkage Disequilibrium report
SSX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SSX2 Gene

Disorders for SSX2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SSX2 Gene - From: OMIM, Orphanet, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sarcoma, synovial
  • synovial sarcoma
sarcoma
  • connective and soft tissue neoplasm
spindle cell synovial sarcoma
  • synovial sarcoma with spindle cell components
- elite association - COSMIC cancer census association via MalaCards
Search SSX2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SSX2_HUMAN
  • Note=A chromosomal aberration involving SSX2 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency). {ECO:0000269 PubMed:7539744, ECO:0000269 PubMed:7951320}.

Relevant External Links for SSX2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSX2
genes like me logo Genes that share disorders with SSX2: view

No data available for Genatlas for SSX2 Gene

Publications for SSX2 Gene

  1. Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript. (PMID: 7495284) Fligman I. … Ladanyi M. (Am. J. Pathol. 1995) 3 4 23 67
  2. The SSX-2 gene, which is involved in the t(X;18) translocation of synovial sarcomas, codes for the human tumor antigen HOM-MEL-40. (PMID: 8840996) TA1reci O. … Pfreundschuh M. (Cancer Res. 1996) 2 3 23
  3. Distinct but overlapping T helper epitopes in the 37-58 region of SSX-2. (PMID: 15596411) Ayyoub M. … Valmori D. (Clin. Immunol. 2005) 3 23
  4. The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PMID: 12007189) de Bruijn D.R.H. … van Kessel A.G. (Genes Chromosomes Cancer 2002) 3 23
  5. The SSX gene family: characterization of 9 complete genes. (PMID: 12216073) Gure A.O. … Chen Y.-T. (Int. J. Cancer 2002) 3 23

Products for SSX2 Gene

Sources for SSX2 Gene

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