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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SSX2 Gene

protein-coding   GIFtS: 53
GCID: GC0XM052725

Synovial Sarcoma, X Breakpoint 2


(Previous symbol: SSX)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Synovial Sarcoma, X Breakpoint 21 2 3     X Breakpoint 21
SSX1 2     X Breakpoint 2B1
Cancer/Testis Antigen 5.22 3     X-Chromosome-Related 21
Tumor Antigen HOM-MEL-402 3     CT5.2A2
CT5.22 3     HD212
Cancer/Testis Antigen Family 51     HOM-MEL-402
Isoform B1     Cancer/Testis Antigen Family 5, Member 2a2
Member 2a1     Protein SSX22
sarcoma1     Sarcoma, Synovial, X-Chromosome-Related 22
synovial1     Synovial Sarcoma, X Breakpoint 2B2
Synovial Sarcoma1     SSX2A3

External Ids:    HGNC: 113361   Entrez Gene: 67572   Ensembl: ENSG000002414767   OMIM: 3001925   UniProtKB: Q163853   

Export aliases for SSX2 gene to outside databases

Previous GC identifers: GC0XP043594 GC0XP050491 GC0XM051377 GC0XM051692 GC0XM052608 GC0XM052742 GC0XM052673 GC0XM049853


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SSX2 Gene:
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins.
These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral
and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based
immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2)
translocations that are characteristically found in all synovial sarcomas. This translocation results in the
fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The
encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene
results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about
45 kb downstream in the opposite orientation on chromosome X. (provided by RefSeq, Jul 2013)

GeneCards Summary for SSX2 Gene: 
SSX2 (synovial sarcoma, X breakpoint 2) is a protein-coding gene. Diseases associated with SSX2 include spindle cell synovial sarcoma, and kidney hemangiopericytoma. An important paralog of this gene is SSX2B.

UniProtKB/Swiss-Prot: SSX2_HUMAN, Q16385
Function: Could act as a modulator of transcription

Gene Wiki entry for SSX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011630.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SSX2 gene promoter:
         C/EBPbeta   p53   NCX/Ncx   HNF-1A   C/EBPalpha   PPAR-gamma1   HNF-1   PPAR-gamma2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSSX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SSX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.22

SSX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSX2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM052725:  view genomic region     (about GC identifiers)

Start:
52,725,946 bp from pter      End:
52,736,249 bp from pter
Size:
10,304 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SSX2_HUMAN, Q16385 (See protein sequence)
Recommended Name: Protein SSX2  
Size: 188 amino acids; 21620 Da
Subunit: Interacts via its N-terminal region with RAB3IP and SSX2IP
Subcellular location: Nucleus
Sequence caution: Sequence=AAB35674.1; Type=Erroneous initiation;
Secondary accessions: Q16404 Q5JS26 Q96IP7 Q9BU88
Alternative splicing: 2 isoforms:  Q16385-1   Q16385-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SSX2: NX_Q16385

Explore proteomics data for SSX2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus (SSX2)
  • View neXtProt modification sites for NX_Q16385

  • SSX2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SSX2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001265626.1  NP_003138.3  NP_783629.1  

    ENSEMBL proteins: 
     ENSP00000338796   ENSP00000338561  

    Human Recombinant Protein Products for SSX2: 
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    Novus Biologicals SSX2 Protein
    Novus Biologicals SSX2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SSX2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----

    SSX2 for ontologies           About GeneDecksing



    SSX2 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for SSX2 

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    Cloud-Clone Corp. ELISAs for SSX2 
    Cloud-Clone Corp. CLIAs for SSX2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR003655 Krueppel-associated_box-rel
     IPR019041 SSXRD_motif
     IPR001909 Krueppel-associated_box

    Graphical View of Domain Structure for InterPro Entry Q16385

    ProtoNet protein and cluster: Q16385

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: SSX2_HUMAN, Q16385
    Similarity: Belongs to the SSX family
    Similarity: Contains 1 KRAB-related domain


    SSX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSX2_HUMAN, Q16385
    Function: Could act as a modulator of transcription

         Genatlas biochemistry entry for SSX2:
    protein SSX2 with homology to Kruppel associated box,KRAB,transcriptional corepressor,complexing with polycomb
    group (PcG) proteins RING1 or BMI1 and associating with chromatin,fused with SYT (SSXT) in synovial sarcoma with
    translocation t(X;18)(p11.2;q11.2) (see BSSX)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding ----
         
    SSX2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SSX2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SSX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SSX2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SSX2 

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SSX2
    SwitchGear 3'UTR luciferase reporter plasmidSSX2 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of SSX2 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSX2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SSX2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for SSX2):
        Transcriptional misregulation in cancer


    SSX2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SSX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for SSX2 (Q163851, 3 ENSP000003387964) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB3IPQ96QF0-21, ENSP000003680864EBI-2210673,EBI-747865 I2D: score=2 STRING: ENSP00000368086
    SSX2IPQ9Y2D81, 3, ENSP000003402794EBI-2210673,EBI-2212028 I2D: score=2 STRING: ENSP00000340279
    RNF2Q994963I2D: score=1 
    SMARCA2P515313I2D: score=1 
    ADRA1DENSP000003687664STRING: ENSP00000368766
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent ----

    SSX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SSX2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SSX2

    3 Novoseek inferred chemical compound relationships for SSX2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 47.2 1 10749136 (1)
    oligonucleotide 0 1 15747098 (1)
    zinc 0 1 7539744 (1)

    Search CenterWatch for drugs/clinical trials and news about SSX2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SSX2 gene (3 alternative transcripts): 
    NM_001278697.1  NM_003147.5  NM_175698.2  

    Unigene Clusters for SSX2:

    Synovial sarcoma, X breakpoint 2
    Hs.289105  [show with all ESTs], Hs.661107  [show with all ESTs]
    Unigene Representative Sequences: NM_001164417, NM_003147
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336777(uc004dqy.1) ENST00000337502(uc004dqz.1) ENST00000476392

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSX2
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SSX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSX2
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSX2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSX2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSX2

    Additional mRNA sequence: 

    AF190791.1 BC002818.2 BC007343.2 BC016957.1 BC069313.1 BC071827.1 BC103863.2 S79332.1 
    Z49105.1 Z49106.1 

    8 DOTS entries:

    DT.203018  DT.121314213  DT.92450034  DT.95157176  DT.113859  DT.121278319  DT.121278317  DT.121314214 

    24/41 AceView cDNA sequences (see all 41):

    BE378730 NM_003147 X86175 BC002818 NM_175698 AF190791 CB156144 CB158928 
    BC071827 CB158955 BC069313 BM806411 BG104299 BE408978 Z49105 BE391023 
    BI520165 BU194624 BU161779 BQ231752 BC007343 BQ222907 CB144604 AL040237 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SSX2 expression in normal human tissues (normalized intensities)      SSX2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTCCCCTC
    SSX2 Expression
    About this image


    SSX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Gonad
             XY Germ Cells Testis Cord

     -- (Integumentary System)
             skin   

    See SSX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SSX2

    SOURCE GeneReport for Unigene clusters: Hs.289105 Hs.661107

    UniProtKB/Swiss-Prot: SSX2_HUMAN, Q16385
    Tissue specificity: Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in
    tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and
    fibrosarcoma cell lines. Not detected in mesenchymal and epithelial cell lines

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for SSX2 (if available)
    TreeFam Gene Tree for SSX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SSX2 gene
    SSX2B1 2  SSX62  SSX42  SSX72  SSX12  SSX52  SSX92  SSX4B2  
    SSX32  
    17 SIMAP similar genes for SSX2 using alignment to 3 protein entries:     SSX2_HUMAN (see all proteins):
    SS18/SSX2 fusion    SSX10    SSX2B    SSX6    SSX3    SSX9
    SS18/SSX1 fusion    SSX7    SSX11    SSX5    SYT-SSX2    SSX1
    SSX4    SSX4B    SSX8    SSX-HSTT    SYT-SSX1

    SSX2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    3 SNPs in SSX2 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs173554291,2
    F--52734233(-) GCCTCG/AGAGAA 4 /S syn11Minor allele frequency- A:0.22MN 184
    rs2006006931,2
    --52736792(+) GAATC-/TTAAGT 2 -- us2k10--------
    rs2017794261,2
    ----52732370(+) AACCTA/GTCTTT 2 -- int10--------

    HapMap Linkage Disequilibrium report for SSX2 (52725946 - 52736249 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SSX2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2740170CNV Deletion23290073
    esv21492CNV Gain19812545
    nsv7446OTHER Inversion18451855

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SSX2
    DNA2.0 Custom Variant and Variant Library Synthesis for SSX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300192    OMIM disorders: --

    UniProtKB/Swiss-Prot: SSX2_HUMAN, Q16385
  • Note=A chromosomal aberration involving SSX2 may be a cause of synovial sarcoma. Translocation
    t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion
    products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position
    of the breakpoint can occur (low frequency)

  • 20/26 diseases for SSX2 (see all 26):    About MalaCards
    spindle cell synovial sarcoma    kidney hemangiopericytoma    synovial sarcoma    biphasic synovial sarcoma
    sarcoma    seminoma    testicular cancer    hemangiopericytoma
    tonsillitis    cutaneous t cell lymphoma    esophageal cancer    germ cell tumors
    multiple myeloma    rhabdomyosarcoma    fibrosarcoma    acute leukemia
    myeloma    neuroblastoma    melanoma    esophagitis

    3 diseases from the University of Copenhagen DISEASES database for SSX2:
    Kidney hemangiopericytoma     Synovial sarcoma     Hemangiopericytoma

    SSX2 for disorders           About GeneDecksing

    10/11 Novoseek inferred disease relationships for SSX2 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sarcoma synovial 95.8 40 10398111 (2), 7951320 (2), 8840996 (2), 15147271 (2) (see all 35)
    testicular cancer 76.8 12 10749136 (2), 14611804 (2), 16224274 (1), 11823502 (1) (see all 9)
    sarcoma 63.9 4 10398111 (1), 12601173 (1), 9788446 (1), 12469233 (1)
    melanoma 48.2 13 10749136 (4), 9378559 (2), 9639388 (2), 12007189 (1) (see all 5)
    tumors 47.1 27 9639388 (3), 18295890 (2), 14611804 (2), 11668506 (1) (see all 18)
    seminoma 43.6 3 11454979 (1), 9639388 (1)
    metastatic melanoma 25.3 1 10749136 (1)
    cancer 24.8 11 9378559 (3), 15603546 (3), 17186289 (1), 15596411 (1) (see all 6)
    metastasis 17.1 1 15781633 (1)
    ovarian cancer 12.9 2 9639388 (1)


    Export disorders for SSX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SSX2 gene, integrated from 9 sources (see all 101):
    (articles sorted by number of sources associating them with SSX2)
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    1. Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript. (PubMed id 7495284)1, 2, 9 Fligman I....Ladanyi M. (1995)
    2. The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PubMed id 12007189)1, 2, 9 de Bruijn D.R.H....van Kessel A.G. (2002)
    3. Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. (PubMed id 7539744)1, 2, 9 Crew A.J.... Cooper C.S. (1995)
    4. Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. (PubMed id 7951320)1, 2, 9 Clark J.... Cooper C.S. (1994)
    5. The SSX-2 gene, which is involved in the t(X;18) translocation of synovial sarcomas, codes for the human tumor antigen HOM-MEL-40. (PubMed id 8840996)1, 3, 9 Tureci O....Pfreundschuh M. (1996)
    6. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Identification of two alternative fusion genes, SYT-SSX1 and SYT- SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas. (PubMed id 7655467)1, 2 de Leeuw B.... Geurts van Kessel A. (1995)
    9. Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines. (PubMed id 10749136)1, 9 dos Santos N.R.... Geurts van Kessel A. (2000)
    10. The SSX gene family: characterization of 9 complete genes. (PubMed id 12216073)1, 9 Gure A.O.... Chen Y.-T. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6757 HGNC: 11336 AceView: SSX2 Ensembl:ENSG00000241476 euGenes: HUgn6757
    ECgene: SSX2 Kegg: 6757 H-InvDB: SSX2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SSX2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SSX2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SSX2 gene:
    Search GeneIP for patents involving SSX2

    GeneCards and IP:
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