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Aliases & Descriptions for SSX2
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases CT5.2 3 CT5.2a 1 , 2 HD21 1 , 2 HOM-MEL-40 1 , 2 , 3 MGC119055 1 , 2 MGC15364 1 , 2 MGC3884 1 , 2 OTTHUMP00000024290 2 OTTHUMP00000024291 2 SSX 2 , 3 SSX2A 3
Descriptions Cancer/testis antigen 5.2 3 cancer/testis antigen family 5, member 2a 2 sarcoma, synovial, X-chromosome-related 2 2 synovial sarcoma, X breakpoint 2 2 , 3 synovial sarcoma, X breakpoint 2, isoform b 2 synovial sarcoma, X breakpoint 2B 2
Search outside databases for aliases for SSX2 genePrevious GC identifers: GC0XP043594 GC0XP050491 GC0XM051377 GC0XM051692 GC0XM052608
Summaries for SSX2 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for SSX2 : The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX)breakpoint proteins. These proteins may function as transcriptional repressors. They are alsocapable of eliciting spontaneously humoral and cellular immune responses in cancer patients, andare potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 geneshave been involved in the t(X;18) translocation characteristically found in all synovial sarcomas.This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsiblefor transforming activity. Two transcript variants encoding distinct isoforms have been identifiedfor this gene. [provided by RefSeq] UniProtKB/Swiss-Prot: SSX2_HUMAN, Q16385 Function : Could act as a modulator of transcription
Gene Wiki entry for SSX2
Genomic Location for SSX2
(According to
GeneLoc and/or
HGNC , and/or
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and/or miRBase ,
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Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the SSX2 gene Entrez Gene cytogenetic band: Xp11.22 Ensembl cytogenetic band: Xp11.22 HGNC cytogenetic band: Xp11.22 SSX2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XM052742:
(about GC identifiers )
Start:
52,742,671 bp from pter
End:
52,752,974 bp from pter
Size:
10,304 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000023.9 NT_011630.14 Proteins for SSX2
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
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Sigma-Aldrich ,
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Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
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Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
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UniProtKB/Swiss-Prot: SSX2_HUMAN, Q16385 (See
protein sequence )Recommended Name: Protein SSX2 Size : 188 amino acids; 21620 Da
Subunit : Interacts via its N-terminal region with RAB3IP and SSX2IP
Subcellular location : Nucleus
Secondary accessions : Q16404 Q5JS26 Q96IP7 Q9BU88Alternative splicing : 2 isoforms : Q16385-1 Q16385-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_003138.3 NP_783629.1 ENSEMBL proteins: ENSP00000338796 ENSP00000338561 Human Recombinant Proteins                OriGene Purified Recombinant Human Proteins (see all 2 ): SSX2 Antibodies for SSX2: Assays for SSX2:
Protein
Domains/ Families for SSX2(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q16385 ProtoNet protein and cluster: Q16385
1 Blocks protein family : IPB001909 KRAB box UniProtKB/Swiss-Prot: SSX2_HUMAN, Q16385 Similarity : Belongs to the SSX familySimilarity : Contains 1 KRAB-related domain
Gene Function for SSX2
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_003147 Applied Biosystems Silencer ® siRNAs for SSX2 Sigma-Aldrich siRNA for SSX2 Sigma-Aldrich shRNA for SSX2 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_003147                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_003147                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_003147  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003147 UniProtKB/Swiss-Prot: SSX2_HUMAN, Q16385 Function : Could act as a modulator of transcription
Genatlas biochemistry entry for SSX2 :protein SSX2 with homology to Kruppel associated box,KRAB,transcriptional corepressor,complexingwith polycomb group (PcG) proteins RING1 or BMI1 and associating with chromatin,fused with SYT(SSXT) in synovial sarcoma with translocation t(X;18)(p11.2;q11.2) (see BSSX) Pathways & Interactions for SSX2
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for SSX2 2 Interacting proteins for SSX2 (ENSP00000338796 3 Q16385 1 ) via UniProtKB, MINT, and/or STRING About this table
Drugs & Compounds for SSX2 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for SSX2 2 Novoseek chemical compound relationships for SSX2 gene
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Transcripts for SSX2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_003147 Sigma-Aldrich siRNA for SSX2 Sigma-Aldrich shRNA for SSX2 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_003147 NM_175698
REFSEQ mRNAs for SSX2 gene (2 alternative transcripts): NM_003147.4 NM_175698.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003147 NM_175698
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_003147                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_003147                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_003147  
Additional cDNA sequence: AF190791.1 BC002818.2 BC007343.2 BC016957.1 BC069313.1 BC071827.1 BC103863.2 S79332.1 Z49105.1 Z49106.1
8 DOTS entries : DT.203018 DT.121314213 DT.92450034 DT.95157176 DT.113859 DT.121278319 DT.121278317 DT.121314214
24/41 AceView cDNA sequences (see all 41
):BE378730 CB158928 AF190791 NM_003147 X86175 CB156144 BC002818 CB158955 NM_175698 BC071827 BQ231752 BG396977 BU194624 BC007343 BE384545 BQ222907 Z49105 CB144604 BC016957 BC069313 BG104299 BE408978 BI520165 BU161779
highest scoring ESTs for SSX2 :AL040237 BC002818 BC007343 BC016957 BC071827 BE391023 BE408978 BE891434 BG104299 BG396977
Unigene Clusters for SSX2: Synovial sarcoma, X breakpoint 2 Hs.289105 [show with all ESTs ] , Hs.661107 [show with all ESTs ] Unigene Representative Sequences: XM_001720499 , NM_003147 GeneLoc Exon Structure 2 Ensembl transcripts including schematic representations : ENST00000336777
ENST00000337502
Expression for SSX2
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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SSX2 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for SSX2 1 / 2 / 3
14 probe-sets matching SSX2 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TACTCCCCTCSOURCE GeneReport for Unigene clusters: Hs.289105 Hs.661107 Expression variation in blood from EXPOLDB for SSX2
UniProtKB/Swiss-Prot: SSX2_HUMAN, Q16385 Tissue specificity : Expressed at high level in the testis. Expressed at low level in thyroid. Notdetected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detectedin rhabdomyosarcoma and fibrosarcoma cell lines. Not detected in mesenchymal and epithelial celllines
Orthologs for SSX2
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
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Gene Trees according to Ensembl )
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Orthologs for SSX2 gene from 1 species
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
chimpanzee (Pan troglodytes)
SSX21
--
synovial sarcoma, X breakpoint 2
98.93(n) 98.72(a)
741661 XM_001143910.1 XP_001143910.1
About this table Species with no ortholog for SSX2 ENSEMBL Gene Tree for SSX2 Paralogs for SSX2 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for SSX2 gene SSX2B 1 2 SSX3 1 2 SSX6 2 SSX4 2 SSX7 2 SSX1 2 SSX5 2 SSX10 2 SSX9 2 SSX4B 2
SNPs/Variants for SSX2 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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Disorders & Mutations for SSX2
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
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Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
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OMIM: 300192 UniProtKB/Swiss-Prot: SSX2_HUMAN, Q16385
A chromosomal aberration involving SSX2 may be a cause of synovial sarcoma. Translocationt(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovialsarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transformingactivity. Heterogeneity in the position of the breakpoint can occur (low frequency)
10/11 Novoseek disease relationships for SSX2 gene (see all 11
)
Disease
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
sarcoma synovial
95.86
40
10398111 (2), 7951320 (2), 8840996 (2), 15147271 (2) (see all 35 )
testicular cancer
77.66
12
10749136 (2), 14611804 (2), 16224274 (1), 11823502 (1) (see all 9 )
sarcoma
65.11
4
10398111 (1), 12601173 (1), 9788446 (1), 12469233 (1)
melanoma
49.65
13
10749136 (4), 9378559 (2), 9639388 (2), 12007189 (1) (see all 5 )
tumors
46.92
27
9639388 (3), 18295890 (2), 14611804 (2), 11668506 (1) (see all 18 )
seminoma
44.83
3
11454979 (1), 9639388 (1)
metastatic melanoma
27.14
1
10749136 (1)
cancer
25.27
11
9378559 (3), 15603546 (3), 17186289 (1), 15596411 (1) (see all 6 )
metastasis
19.15
1
15781633 (1)
ovarian cancer
14.98
2
9639388 (1)
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Medical News for SSX2 (Possibly Related Articles in
Doctor's Guide )
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Publications for SSX2 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/82 PubMed articles for SSX2 gene (see all 82
): Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript. (PubMed id 7495284) 1, 3, 4 Fligman I....Ladanyi M. (1995) The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PubMed id 12007189) 1, 3, 4 de Bruijn D.R.H....van Kessel A.G. (2002) Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. (PubMed id 7539744) 1, 3, 4 Crew A.J.... Cooper C.S. (1995) Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. (PubMed id 7951320) 1, 3, 4 Clark J....Cooper C.S. (1994) The SSX-2 gene, which is involved in the t(X;18) translocation of synovial sarcomas, codes for the human tumor antigen HOM-MEL-40. (PubMed id 8840996) 1, 2, 3 Tureci O....Pfreundschuh M. (1996) The DNA sequence of the human X chromosome. (PubMed id 15772651) 3, 4 Ross M.T.... Bentley D.R. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Identification of two alternative fusion genes, SYT-SSX1 and SYT- SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas. (PubMed id 7655467) 3, 4 de Leeuw B.... Geurts van Kessel A. (1995) Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines. (PubMed id 10749136) 1, 3 dos Santos N.R.... Geurts van Kessel A. (2000) The SSX gene family: characterization of 9 complete genes. (PubMed id 12216073) 1, 3 Gure A.O.... Chen Y.-T. (2002)
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Genome Databases showing SSX2
(According to
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euGenes ,
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and/or
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Specialized Databases showing SSX2 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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