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SSX1 Gene

protein-coding   GIFtS: 58
GCID: GC0XP048114

Synovial Sarcoma, X Breakpoint 1

  See SSX1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Synovial Sarcoma, X Breakpoint 11 2 3     Member 11
Cancer/Testis Antigen 5.12 3     Cancer/Testis Antigen Family 5, Member 12
CT5.12 3     Protein SSX12
SSRC2 5     Sarcoma, Synovial, X-Chromosome-Related 12
Cancer/Testis Antigen Family 51     

External Ids:    HGNC: 113351   Entrez Gene: 67562   Ensembl: ENSG000001267527   OMIM: 3128205   UniProtKB: Q163843   

Export aliases for SSX1 gene to outside databases

Previous GC identifers: GC0XP046917 GC0XP046332 GC0XP046794 GC0XP047160 GC0XP047871 GC0XP047999 GC0XP047958 GC0XP045828


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SSX1 Gene:
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins.
These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral
and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based
immunotherapy. This gene, and also the SSX2 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2)
translocations that are characteristically found in all synovial sarcomas. This translocation results in the
fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The
encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene
results in multiple transcript variants. A related pseudogene has been identified on chromosome X. (provided by
RefSeq, Jul 2013)

GeneCards Summary for SSX1 Gene:
SSX1 (synovial sarcoma, X breakpoint 1) is a protein-coding gene. Diseases associated with SSX1 include extraskeletal mesenchymal chondrosarcoma, and mesenchymal chondrosarcoma. GO annotations related to this gene include transcription corepressor activity and nucleic acid binding. An important paralog of this gene is SSX5.

UniProtKB/Swiss-Prot: SSX1_HUMAN, Q16384
Function: Could act as a modulator of transcription

Gene Wiki entry for SSX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_079573.5  
Regulatory elements:
   Regulatory transcription factor binding sites in the SSX1 gene promoter:
         HOXA9   HOXA9B   ATF-2   FOXD3   POU3F2   CRE-BP1   Sox9   Meis-1a   Meis-1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSSX1 promoter sequence
   Search Chromatin IP Primers for SSX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SSX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

SSX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSX1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP048114:  view genomic region     (about GC identifiers)

Start:
48,114,752 bp from pter      End:
48,126,879 bp from pter
Size:
12,128 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SSX1_HUMAN, Q16384 (See protein sequence)
Recommended Name: Protein SSX1  
Size: 188 amino acids; 21931 Da
Secondary accessions: A3KN76 Q08AJ2 Q5JQ64

Explore the universe of human proteins at neXtProt for SSX1: NX_Q16384

Explore proteomics data for SSX1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SSX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001265620.1  NP_005626.1  

    ENSEMBL proteins: 
     ENSP00000366118  

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    Cloud-Clone Corp. Proteins for SSX1

     
    Search eBioscience for Proteins for SSX1 

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    LSBio Antibodies in human, mouse, rat for SSX1

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    Search eBioscience for ELISAs for SSX1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR003655 Krueppel-associated_box-rel
     IPR019041 SSXRD_motif
     IPR028804 SSX
     IPR001909 Krueppel-associated_box

    Graphical View of Domain Structure for InterPro Entry Q16384

    ProtoNet protein and cluster: Q16384

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: SSX1_HUMAN, Q16384
    Similarity: Belongs to the SSX family
    Similarity: Contains 1 KRAB-related domain


    Find genes that share domains with SSX1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSX1_HUMAN, Q16384
    Function: Could act as a modulator of transcription

         Genatlas biochemistry entry for SSX1:
    protein SSX1 with homology to Kruppel associated box,KRAB,transcriptional corepressor,complexing with polycomb
    group (PcG) proteins RING1 or BMI1 and associating with chromatin,fused with SYT (SSXT) in synovial sarcoma with
    translocation t(X;18)(p11.2;q11.2) (see BSSX)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0003714transcription corepressor activity TAS10072425
         
    Find genes that share ontologies with SSX1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SSX1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SSX1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SSX1

    miRNA
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    miRTarBase miRNAs that target SSX1:
    hsa-mir-7-5p (MIRT025895)

    Block miRNA regulation of human, mouse, rat SSX1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate SSX1:
    hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-512-3p
    SwitchGear 3'UTR luciferase reporter plasmidSSX1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SSX1

    Gene Editing
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    Sino Biological Human cDNA Clone for SSX1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSX1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with SSX1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SSX1 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer


    Find genes that share SuperPaths with SSX1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for SSX1):
        Transcriptional misregulation in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SSX1
    Interactions:

        Search GeneGlobe Interaction Network for SSX1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for SSX1 (Q163843 ENSP000003661184) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LHX4Q969G23, ENSP000002637264I2D: score=1 STRING: ENSP00000263726
    FUBP3Q96I243, ENSP000003181774I2D: score=1 STRING: ENSP00000318177
    SNAI1O958633I2D: score=1 
    ALDH18A1ENSP000003602684STRING: ENSP00000360268
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with SSX1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SSX1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SSX1 gene (2 alternative transcripts): 
    NM_001278691.1  NM_005635.3  

    Unigene Cluster for SSX1:

    Synovial sarcoma, X breakpoint 1
    Hs.434142  [show with all ESTs]
    Unigene Representative Sequence: NM_005635
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000376919(uc004djb.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat SSX1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate SSX1:
    hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-512-3p
    SwitchGear 3'UTR luciferase reporter plasmidSSX1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SSX1
    Predesigned siRNA for gene silencing in human, mouse, rat SSX1
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    GenScript: all cDNA clones in your preferred vector: SSX1 (NM_005635)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSX1
    Primer
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    OriGene qPCR primer pairs and template standards for SSX1
    OriGene qSTAR qPCR primer pairs in human, mouse for SSX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SSX1
      QuantiTect SYBR Green Assays in human, mouse, rat SSX1
      QuantiFast Probe-based Assays in human, mouse, rat SSX1

    Additional mRNA sequence: 

    BC001003.2 BC125151.1 BC128611.1 BC133693.1 BC150487.2 X86174.1 

    3 DOTS entries:

    DT.40315656  DT.92450035  DT.92450031 

    Selected AceView cDNA sequences (see all 30):

    BU170242 BE408883 BE535379 NM_005635 AA954482 BQ432374 AA378285 BQ229996 
    CB160731 BE277023 BC001003 X86174 BQ434972 BI831262 BE410950 BF211314 
    BU619846 BQ224117 BP428754 BQ774004 BE777476 BU178412 BQ774650 AW951509 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SSX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SSX1 Expression
    About this image

    SSX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SSX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.434142

    UniProtKB/Swiss-Prot: SSX1_HUMAN, Q16384
    Tissue specificity: Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in
    tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and
    fibrosarcoma cell lines. Not detected in mesenchymal and epithelial cell lines

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for SSX1 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ssxb25 synovial sarcoma, X member B, breakpoint 2   --   X (3.83 cM) 8454345 


    ENSEMBL Gene Tree for SSX1 (if available)
    TreeFam Gene Tree for SSX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SSX1 gene
    SSX52  SSX2B2  SSX22  SSX42  SSX72  SSX4B2  SSX32  
    14 SIMAP similar genes for SSX1 using alignment to 1 protein entry:     SSX1_HUMAN:
    SYT-SSX1    SSX8    SSX6    SYT-SSX2    SSX5    SSX4B
    SSX2B    SSX7    SSX3    SSX9    SSX4    SSX2
    SSX10    PRDM9

    Find genes that share paralogs with SSX1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SSX1 (see all 328)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901351691,2
    --48032565(+) CCTGCC/TGACAA 1 -- us2k10--------
    rs78846411,2
    C,F,A,H--48032662(+) tttgcG/Agtaat 1 -- us2k16Minor allele frequency- A:0.45NS EA NA 305
    rs43132831,2
    C,F,A,H--48032769(+) AACAAG/ATAGTC 1 -- us2k14Minor allele frequency- A:0.45NA 11
    rs45001951,2
    C,F,A,H--48032909(+) tcagcG/Agggac 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs1824101341,2
    --48033076(+) CTCTTA/GAGCCT 1 -- us2k10--------
    rs1852635461,2
    --48033348(+) ATGAGC/TTCCCT 1 -- us2k10--------
    rs1924829061,2
    --48033385(+) TACTCA/TTTTTA 1 -- us2k10--------
    rs1838709811,2
    --48033487(+) AAGTGG/TTTTTT 1 -- us2k10--------
    rs1888863651,2
    --48033517(+) TAAAAA/TTTTTT 1 -- us2k10--------
    rs1929298481,2
    --48033763(+) ACCTCA/GTACTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SSX1 (48114752 - 48126879 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SSX1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671998CNV Deletion23128226
    esv2740147CNV Deletion23290073
    esv2740145CNV Deletion23290073
    nsv519165CNV Loss19592680
    nsv519305CNV Gain19592680
    esv2752324CNV Gain17911159
    esv25781CNV Gain19812545
    nsv523595CNV Gain19592680
    esv32909CNV Gain+Loss17666407
    dgv2442e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): SSX1
    Locus Specific Mutation Databases (LSDB): SSX1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SSX1
    DNA2.0 Custom Variant and Variant Library Synthesis for SSX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 312820   
    OMIM disorders: 300813  
    UniProtKB/Swiss-Prot: SSX1_HUMAN, Q16384
  • Note=A chromosomal aberration involving SSX1 may be a cause of synovial sarcoma. Translocation
    t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion
    products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position
    of the breakpoint can occur (low frequency)

  • 5 diseases for SSX1:    
    About MalaCards
    extraskeletal mesenchymal chondrosarcoma    mesenchymal chondrosarcoma    synovial sarcoma    sarcoma
    brain small vessel disease with hemorrhage

    3 diseases from the University of Copenhagen DISEASES database for SSX1:
    Synovial sarcoma     Sarcoma     Extraskeletal mesenchymal chondrosarcoma

    Find genes that share disorders with SSX1           About GenesLikeMe

    4 Novoseek inferred disease relationships for SSX1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sarcoma synovial 93.8 23 7539744 (2), 10404078 (1), 17197895 (1), 17186289 (1) (see all 18)
    sarcoma 62.2 2 10399965 (1), 12469233 (1)
    melanoma 25.6 2 12007189 (1), 9378559 (1)
    cancer 0 2 17186289 (1), 15603546 (1)

    Genetic Association Database (GAD): SSX1
    Human Genome Epidemiology (HuGE) Navigator: SSX1 (1 document)

    Export disorders for SSX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SSX1 gene, integrated from 10 sources (see all 61):
    (articles sorted by number of sources associating them with SSX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two alternative fusion genes, SYT-SSX1 and SYT- SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas. (PubMed id 7655467)1, 2, 3 de Leeuw B.... Geurts van Kessel A. (Hum. Mol. Genet. 1995)
    2. Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. (PubMed id 7539744)1, 2, 9 Crew A.J.... Cooper C.S. (EMBO J. 1995)
    3. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1, 4 Chapuis J....Lambert J.C. (Mol. Psychiatry 2009)
    4. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PubMed id 12007189)1, 9 de Bruijn D.R.H....van Kessel A.G. (Genes Chromosomes Cancer 2002)
    7. Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus. (PubMed id 10072425)1, 9 Thaete C....Goodwin G. (Hum. Mol. Genet. 1999)
    8. Loss of SS18-SSX1 Inhibits Viability and Induces Apoptosis in Synovial Sarcoma. (PubMed id 23716114)1 Carmody Soni E.E....Toretsky J.A. (Clin. Orthop. Relat. Res. 2013)
    9. Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma. (PubMed id 23540691)1 Kadoch C. and Crabtree G.R. (Cell 2013)
    10. A poorly differentiated synovial sarcoma arising from the pulmonary valve. (PubMed id 23701986)1 Yin L....Zhang H. (Cardiovasc. Pathol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6756 HGNC: 11335 AceView: SSX1 Ensembl:ENSG00000126752 euGenes: HUgn6756
    ECgene: SSX1 Kegg: 6756 H-InvDB: SSX1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SSX1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SSX1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
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    Patent Information for SSX1 gene:
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