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Aliases & Descriptions for SSX1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CT5.1 1, 2, 3 | | MGC150425 2 | | MGC5162 2 | | OTTHUMP00000023245 2 | | SSRC 2, 5 |
| | | Descriptions |
|---|
| Cancer/testis antigen 5.1 3 | | cancer/testis antigen family 5, member 1 2 | | sarcoma, synovial, X-chromosome-related 1 2 | | synovial sarcoma, X breakpoint 1 2, 3 |
|
| | Search outside databases for aliases for SSX1 genePrevious GC identifers: GC0XP046917 GC0XP046332 GC0XP046794 GC0XP047160 GC0XP047871 GC0XP047999 |
Summaries for SSX1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for SSX1: The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity. [provided by RefSeq] UniProtKB/Swiss-Prot: SSX1_HUMAN, Q16384Function: Could act as a modulator of transcriptionGene Wiki entry for SSX1 |
Genomic Location for SSX1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the SSX1 gene 
Entrez Gene cytogenetic band: Xp11.23-p11.22 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23SSX1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP047958:
(about GC identifiers)
Start:
|
47,957,054 bp from pter |
End:
|
48,185,976 bp from pter |
Size:
|
228,923 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000023.9 NT_079573.3
| Proteins for SSX1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SSX1_HUMAN, Q16384 (See
protein sequence)Recommended Name: Protein SSX1 Size: 188 amino acids; 21931 Da
Secondary accessions: A3KN76 Q08AJ2 Q5JQ64Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005626.1
ENSEMBL proteins: ENSP00000366118 ENSP00000385051
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: SSX1 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for SSX1: Assays for SSX1: | Protein
Domains/ Families for SSX1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q16384
ProtoNet protein and cluster: Q16384 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: SSX1_HUMAN, Q16384Similarity: Belongs to the SSX familySimilarity: Contains 1 KRAB-related domain | Gene Function for SSX1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005635
Applied Biosystems Silencer® siRNAs for SSX1
Sigma-Aldrich siRNA for SSX1  Sigma-Aldrich shRNA for SSX1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005635                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005635                                  untagged cDNA clone in CMV expression vector: NM_005635 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005635
UniProtKB/Swiss-Prot: SSX1_HUMAN, Q16384Function: Could act as a modulator of transcriptionGenatlas biochemistry entry for SSX1:protein SSX1 with homology to Kruppel associated box,KRAB,transcriptional corepressor,complexing with polycomb group (PcG) proteins RING1 or BMI1 and associating with chromatin,fused with SYT (SSXT) in synovial sarcoma with translocation t(X;18)(p11.2;q11.2) (see BSSX)2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for SSX1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/13 Interacting proteins for SSX1 (ENSP000003661183) via UniProtKB, MINT, and/or STRING (see all 13
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006350 | transcription |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | About this table
|
Drugs & Compounds for SSX1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for SSX1 2 PharmGKB drug compound relationships for SSX1 geneAbout this table
|
Transcripts for SSX1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005635
Sigma-Aldrich siRNA for SSX1  Sigma-Aldrich shRNA for SSX1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005635 REFSEQ mRNAs for SSX1 gene: NM_005635.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005635               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005635                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005635                                  untagged cDNA clone in CMV expression vector: NM_005635  Additional cDNA sequence: BC148313.2 4 DOTS entries: DT.40315656 DT.92450035 DT.92450031 DT.95361396 24/30 AceView cDNA sequences (see all 30
):BE408883 BU170242 NM_005635 BE535379 AA954482 CB160731 X86174 BE277023 BQ229996 BQ432374 AA378285 BQ434972 BC001003 BQ224117 BU619846 BQ774004 AW951509 BQ774650 BE410950 BE777476 BU178412 BI831262 BP428754 BF211314
highest scoring ESTs for SSX1:X86174 AA378285 AA954482 AW951509 BC001003 BE277023 BE535379 BQ432374 BQ434972 BQ774004 Unigene Clusters for SSX1: Synovial sarcoma, X breakpoint 1 Hs.434142 [show with all ESTs], Hs.694472 , Hs.713144 Unigene Representative Sequences: NM_005635, BC133693, BC148313
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000376919
ENST00000403001
|
Expression for SSX1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| SSX1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for SSX1
1 / 2 / 3 6 probe-sets matching SSX1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AGCCTGCGGG
SOURCE GeneReport for Unigene clusters: Hs.434142 Hs.694472 Hs.713144
Expression variation in blood from EXPOLDB for SSX1 UniProtKB/Swiss-Prot: SSX1_HUMAN, Q16384Tissue specificity: Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and fibrosarcoma cell lines. Not detected in mesenchymal and epithelial cell lines |
Orthologs for SSX1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SSX1 gene from 2 species
About this table Species with no ortholog for SSX1
ENSEMBL Gene Tree for SSX1 | Paralogs for SSX1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for SSX1 gene
- SSX22 SSX2B2 SSX62 SSX42 SSX72 SSX52 SSX102 SSX92
- SSX4B2 SSX32
|
SNPs/Variants for SSX1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for SSX1 (up to first 250kb)
|
Disorders & Mutations for SSX1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 312820 UniProtKB/Swiss-Prot: SSX1_HUMAN, Q16384
A chromosomal aberration involving SSX1 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency)4 Novoseek disease relationships for SSX1 gene
About this table
1 PharmGKB disease relationship for SSX1 geneAbout this table
Human Genome Epidemiology Navigator: SSX1 (1 document)
|
Medical News for SSX1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for SSX1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/49 PubMed articles for SSX1 gene (see all 49
):- Identification of two alternative fusion genes, SYT-SSX1 and SYT- SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas. (PubMed id 7655467)2, 3, 4 de Leeuw B.... Geurts van Kessel A. (1995)
- Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. (PubMed id 7539744)1, 3, 4 Crew A.J.... Cooper C.S. (1995)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)3, 4 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PubMed id 12007189)1, 3 de Bruijn D.R.H....van Kessel A.G. (2002)
- Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus. (PubMed id 10072425)1, 3 Thaete C....Goodwin G. (1999)
- Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)3 Chapuis J....Lambert J.C. (2009)
- Comparisons for detecting NY-ESO-1 mRNA expression levels in hepatocellular carcinoma tissues. (PubMed id 19212631)3 Wang X.Y....Cai J. (2009)
- Downregulation of SS18-SSX1 expression by small interfering RNA inhibits growth and induces apoptosis in human synovial sarcoma cell line HS-SY-II in vitro. (PubMed id 18714179)3 Peng C....Zhao H. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
|
Search for SSX1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SSX1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing SSX1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SSX1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for SSX1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for SSX1:

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