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SSU72 Gene

protein-coding   GIFtS: 54
GCID: GC01M001477

SSU72 RNA Polymerase II CTD Phosphatase Homolog (S. Cerevisiae)

(Previous name: Ssu72 RNA polymerase II CTD phosphatase homolog (yeast))
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SSU72 RNA Polymerase II CTD Phosphatase Homolog (S. Cerevisiae)1 2     HSPC1822
CTD Phosphatase SSU722 3     PNAS-1202
EC 3.1.3.163 8     RNA Polymerase II Subunit A C-Terminal Domain Phosphatase SSU722
Ssu72 RNA Polymerase II CTD Phosphatase Homolog (Yeast)1     

External Ids:    HGNC: 250161   Entrez Gene: 291012   Ensembl: ENSG000001600757   UniProtKB: Q9NP773   

Export aliases for SSU72 gene to outside databases

Previous GC identifers: GC01M001563 GC01M001466 GC01M000757


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SSU72 Gene:
SSU72 (SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with SSU72 include malaria. GO annotations related to this gene include CTD phosphatase activity.

UniProtKB/Swiss-Prot: SSU72_HUMAN, Q9NP77
Function: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II.
Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with
SYMPK




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SSU72 gene promoter:
         AhR   TBP   ISGF-3   SREBP-1c   c-Ets-1   Roaz   Arnt   SREBP-1b   SREBP-1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSSU72 promoter sequence
   Search Chromatin IP Primers for SSU72

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SSU72


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36

SSU72 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSU72 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001477:  view genomic region     (about GC identifiers)

Start:
1,477,053 bp from pter      End:
1,510,262 bp from pter
Size:
33,210 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SSU72_HUMAN, Q9NP77 (See protein sequence)
Recommended Name: RNA polymerase II subunit A C-terminal domain phosphatase SSU72  
Size: 194 amino acids; 22574 Da
Subunit: Interacts with RB1. Interacts with GTF2B and CD226. Interacts with SYMPK
4 PDB 3D structures from and Proteopedia for SSU72:
3O2Q (3D)        3O2S (3D)        4H3H (3D)        4H3K (3D)    
Secondary accessions: Q9BZS6 Q9H933
Alternative splicing: 2 isoforms:  Q9NP77-1   Q9NP77-2   

Explore the universe of human proteins at neXtProt for SSU72: NX_Q9NP77

Explore proteomics data for SSU72 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys28, Lys43, Lys73
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SSU72 (Q9NP77) (see all 9)
     YDFKTTY  LGAFLICE  TCEERVYD  KSGRTFLHT 


    See SSU72 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_054907.1  
    ENSEMBL proteins: 
     ENSP00000291386   ENSP00000351955  

    SSU72 Human Recombinant Protein Products:

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    OriGene Purified Protein for SSU72
    OriGene Protein Over-expression Lysate for SSU72
    OriGene MassSpec for SSU72
    OriGene Custom Protein Services for SSU72
    GenScript Custom Purified and Recombinant Proteins Services for SSU72
    Novus Biologicals SSU72 Proteins
    Novus Biologicals SSU72 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SSU72
    Cloud-Clone Corp. Proteins for SSU72

    SSU72 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for SSU72

    SSU72 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SSU72
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SSU72
    Cloud-Clone Corp. CLIAs for SSU72


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR006811 RNA_pol_II_suA

    Graphical View of Domain Structure for InterPro Entry Q9NP77

    ProtoNet protein and cluster: Q9NP77

    UniProtKB/Swiss-Prot: SSU72_HUMAN, Q9NP77
    Similarity: Belongs to the SSU72 phosphatase family


    SSU72 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSU72_HUMAN, Q9NP77
    Function: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II.
    Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with
    SYMPK
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Enzyme Number (IUBMB): EC 3.1.3.161 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0005515protein binding IPI--
    GO:0008420CTD phosphatase activity IDA--
         
    SSU72 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SSU72
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SSU72

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SSU72
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SSU72

    miRNA
    Products:
        
    miRTarBase miRNAs that target SSU72:
    hsa-mir-16-5p (MIRT031949), hsa-mir-7-5p (MIRT025930)

    Block miRNA regulation of human, mouse, rat SSU72 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SSU72:
    hsa-miR-548d-3p hsa-miR-548am hsa-miR-548x hsa-miR-1252 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidSSU72 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SSU72
    Predesigned siRNA for gene silencing in human, mouse, rat SSU72

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SSU72

    Clone
    Products:
         
    OriGene clones in human, mouse for SSU72 (see all 7)
    OriGene ORF clones in mouse, rat for SSU72
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SSU72 (NM_014188)
    Sino Biological Human cDNA Clone for SSU72
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSU72
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSU72

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SSU72
    Browse ESI BIO Cell Lines and PureStem Progenitors for SSU72 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSU72


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SSU72_HUMAN, Q9NP77: Nucleus. Cytoplasm. Note=Predominantly in the cytosol
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion2
    cytosol1
    extracellular1
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    SSU72 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SSU72 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA surveillance pathway
    mRNA surveillance pathway
    2Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SSU72
        Chromatin Regulation / Acetylation



    1 Kegg Pathway  (Kegg details for SSU72):
        mRNA surveillance pathway


    SSU72 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SSU72: 
              Protein Phosphatases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SSU72

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SSU72 (Q9NP771, 2, 3 ENSP000002913864) via UniProtKB, MINT, STRING, and/or I2D (see all 126)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAD21O602161, 2, 3, ENSP000002973384EBI-2515416,EBI-80739 MINT-8081286 MINT-8081321 MINT-8081344 MINT-8081406 MINT-8080160 MINT-8081393 MINT-8081303 MINT-8081377 MINT-8080156 I2D: score=2 STRING: ENSP00000297338
    SMC3Q9UQE72, 3, ENSP000003547204MINT-8081286 MINT-8081321 MINT-8080160 MINT-8081303 I2D: score=1 STRING: ENSP00000354720
    SMC1AQ146832, 3, ENSP000003234214MINT-8081321 MINT-8080160 MINT-8081303 I2D: score=1 STRING: ENSP00000323421
    STAG2Q8N3U41, 2, 3, ENSP000002180894EBI-2515416,EBI-1057252 MINT-8081286 MINT-8081321 MINT-8080160 MINT-8081365 MINT-8081377 I2D: score=2 STRING: ENSP00000218089
    CPSF1Q105703, ENSP000003393534I2D: score=4 STRING: ENSP00000339353
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006378mRNA polyadenylation IMP--
    GO:0006397mRNA processing ----
    GO:0070940dephosphorylation of RNA polymerase II C-terminal domain IDA--

    SSU72 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SSU72

    1 HMDB Compound for SSU72    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SSU72 gene: 
    NM_014188.2  

    Unigene Cluster for SSU72:

    SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)
    Hs.549751  [show with all ESTs]
    Unigene Representative Sequence: AK023110
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000291386(uc001agd.3 uc009vkg.1) ENST00000378726 ENST00000378725
    ENST00000359060(uc001age.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SSU72 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SSU72:
    hsa-miR-548d-3p hsa-miR-548am hsa-miR-548x hsa-miR-1252 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidSSU72 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SSU72
    Predesigned siRNA for gene silencing in human, mouse, rat SSU72
    Clone
    Products:
         
    OriGene clones in human, mouse for SSU72 (see all 7)
    OriGene ORF clones in mouse, rat for SSU72
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SSU72 (NM_014188)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSU72
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSU72
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SSU72
    OriGene qSTAR qPCR primer pairs in human, mouse for SSU72
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SSU72
      QuantiTect SYBR Green Assays in human, mouse, rat SSU72
      QuantiFast Probe-based Assays in human, mouse, rat SSU72

    Additional mRNA sequence: 

    AB593172.1 AF161530.1 AF277178.1 AJ276409.1 AK001809.1 AK023110.1 AK127149.1 AK297505.1 
    AK310067.1 BC008070.2 BC018909.2 

    15 DOTS entries:

    DT.75119083  DT.100711154  DT.312838  DT.100819158  DT.121421659  DT.100744110  DT.121421713  DT.102839757 
    DT.97854164  DT.87078440  DT.91756632  DT.95209542  DT.99965663  DT.121421656  DT.95209543 

    Selected AceView cDNA sequences (see all 429):

    AW027536 BE744551 AA642661 AI769430 BQ774740 AA348928 AI418548 BQ638551 
    AK127149 AA064925 BU849220 AJ276409 AI300423 Z40614 BE877617 BM996950 
    AA203523 CA446346 CB850775 BM915409 CD367419 AI457365 AI168033 AA298641 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SSU72 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCCGCCTC
    SSU72 Expression
    About this image

    SSU72 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SSU72 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.549751
        Pathway & Disease-focused RT2 Profiler PCR Array including SSU72: 
              Protein Phosphatases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SSU72
    OriGene qSTAR qPCR primer pairs in human, mouse for SSU72
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SSU72
    QuantiTect SYBR Green Assays in human, mouse, rat SSU72
    QuantiFast Probe-based Assays in human, mouse, rat SSU72
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSU72

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SSU72 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ssu721 , 5 Ssu72 RNA polymerase II CTD phosphatase homolog (yeast)1, 5 90.72(n)1
    98.97(a)1
      4 (87.07 cM)5
    689911  NM_026899.31  NP_081175.21 
     1557048005 
    chicken
    (Gallus gallus)
    Aves SSU721 SSU72 RNA polymerase II CTD phosphatase homolog (S. more 86.77(n)
    98.97(a)
      419410  NM_001007875.1  NP_001007876.1 
    lizard
    (Anolis carolinensis)
    Reptilia SSU726
    SSU72 RNA polymerase II CTD phosphatase homolog (S...
    98(a)
    1 ↔ 1
    GL344201.1(7875-43825)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX848863.12   -- 78.58(n)    BX848863.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059504.12   -- 80.43(n)   393701  BC059504.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ssu721 Ssu72 ortholog 61.78(n)
    61.26(a)
      32973  NM_134498.3  NP_608342.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ssup-721 ssup-72 57.47(n)
    57.29(a)
      188472  NM_062985.3  NP_495386.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSU72(YNL222W)4
    SSU721
    Transcription/RNA-processing factor that associates more4
    SSU721
    50.37(n)1
    48.33(a)1
      14(229094-229714)4
    8554991, 4  NP_014177.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G738201 AT1G73820 56.61(n)
    51.85(a)
      843718  NM_106042.2  NP_177523.1 
    rice
    (Oryza sativa)
    Liliopsida AK069543.12   -- 74.29(n)    AK069543.1 


    ENSEMBL Gene Tree for SSU72 (if available)
    TreeFam Gene Tree for SSU72 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SSU72 gene

    SSU72 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for SSU72 (see all 8)
    PGOHUM00000257797 PGOHUM00000257798 PGOHUM00000257799 PGOHUM00000257868 PGOHUM00000242562


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SSU72 (see all 846)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1833577361,2
    --1477863(+) ACAGCA/GGGGCC 1 -- int10--------
    rs1865630091,2
    --1477987(+) CCAGAC/GTGAGC 1 -- int10--------
    rs37661801,2
    C,F,A,H--1478153(-) ATTGCG/ACGATT 1 -- int137Minor allele frequency- A:0.29NS EA NA WA CSA 3566
    rs37661791,2
    C,F,A,H--1478173(-) AAAATC/GTCGTC 1 -- int19Minor allele frequency- G:0.32NA WA CSA EA 372
    rs37661781,2
    C,F,A,H--1478180(-) TCATAG/AGAAAA 1 -- int123Minor allele frequency- A:0.29NS EA NA WA CSA 2354
    rs1897616271,2
    --1478247(+) TGGACC/TGTGAG 1 -- int10--------
    rs767566591,2
    F--1478380(+) TCTTTC/TTTGGT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1456117931,2
    C--1478690(+) GCACCA/GCATCC 1 -- int10--------
    rs556944631,2
    C--1478694(+) CGCATC/GCCGGA 1 -- int10--------
    rs66659731,2
    C,F--1478880(+) AGCTGG/TGGAGT 1 -- int18Minor allele frequency- T:0.32NA WA EA 368

    HapMap Linkage Disequilibrium report for SSU72 (1477053 - 1510262 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SSU72 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748029CNV Deletion23290073
    esv2675022CNV Deletion23128226
    esv2747918CNV Deletion23290073
    esv1010850CNV Insertion20482838
    esv1301718CNV Insertion17803354
    nsv871954CNV Loss21882294
    dgv42n71CNV Loss21882294
    dgv10n71CNV Loss21882294
    dgv34n71CNV Loss21882294
    nsv871837CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for SSU72:    
    About MalaCards
    malaria


    SSU72 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SSU72
    Human Genome Epidemiology (HuGE) Navigator: SSU72 (1 document)

    Export disorders for SSU72 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SSU72 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with SSU72)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Conserved and specific functions of mammalian ssu72. (PubMed id 15659578)1, 2, 3 St Pierre B....Zacksenhaus E. (Nucleic Acids Res. 2005)
    2. An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72. (PubMed id 23070812)1, 2 Xiang K.... Tong L. (Genes Dev. 2012)
    3. Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. (PubMed id 20861839)1, 2 Xiang K....Tong L. (Nature 2010)
    4. High resolution linkage and linkage disequilibrium analyses of chromosome 1p36 SNPs identify new positional candidate genes for low bone mineral density. (PubMed id 18597038)1, 4 Zhang H....Devoto M. (Osteoporos Int 2009)
    5. Ssu72 Is an RNA polymerase II CTD phosphatase. (PubMed id 15125841)1, 3 Krishnamurthy S....Hampsey M. (Mol. Cell 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    8. RNA polymerase II termination involves C-terminal-domain tyrosine dephosphorylation by CPF subunit Glc7. (PubMed id 24413056)1 Schreieck A....Passmore L.A. (amp 2014)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29101 HGNC: 25016 AceView: HSPC182 Ensembl:ENSG00000160075 euGenes: HUgn29101
    ECgene: SSU72 Kegg: 29101 H-InvDB: SSU72

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SSU72 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SSU72 gene:
    Search GeneIP for patents involving SSU72

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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