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Aliases for SSU72 Gene

Aliases for SSU72 Gene

  • SSU72 Homolog, RNA Polymerase II CTD Phosphatase 2 3 5
  • CTD Phosphatase SSU72 3 4
  • EC 3.1.3.16 4 63
  • SSU72 RNA Polymerase II CTD Phosphatase Homolog (S. Cerevisiae) 2
  • Ssu72 RNA Polymerase II CTD Phosphatase Homolog (Yeast) 2
  • PNAS-120 3
  • HSPC182 3

External Ids for SSU72 Gene

Previous GeneCards Identifiers for SSU72 Gene

  • GC01M001563
  • GC01M001466
  • GC01M000757
  • GC01M001477

Summaries for SSU72 Gene

GeneCards Summary for SSU72 Gene

SSU72 (SSU72 Homolog, RNA Polymerase II CTD Phosphatase) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation and mRNA surveillance pathway. GO annotations related to this gene include phosphoprotein phosphatase activity and CTD phosphatase activity.

UniProtKB/Swiss-Prot for SSU72 Gene

  • Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSU72 Gene

Genomics for SSU72 Gene

Regulatory Elements for SSU72 Gene

Enhancers for SSU72 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SSU72 on UCSC Golden Path with GeneCards custom track

Promoters for SSU72 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SSU72 on UCSC Golden Path with GeneCards custom track

Genomic Location for SSU72 Gene

Chromosome:
1
Start:
1,541,673 bp from pter
End:
1,574,882 bp from pter
Size:
33,210 bases
Orientation:
Minus strand

Genomic View for SSU72 Gene

Genes around SSU72 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSU72 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSU72 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSU72 Gene

Proteins for SSU72 Gene

  • Protein details for SSU72 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP77-SSU72_HUMAN
    Recommended name:
    RNA polymerase II subunit A C-terminal domain phosphatase SSU72
    Protein Accession:
    Q9NP77
    Secondary Accessions:
    • Q9BZS6
    • Q9H933

    Protein attributes for SSU72 Gene

    Size:
    194 amino acids
    Molecular mass:
    22574 Da
    Quaternary structure:
    • Interacts with RB1. Interacts with GTF2B and CD226. Interacts with SYMPK.

    Three dimensional structures from OCA and Proteopedia for SSU72 Gene

    Alternative splice isoforms for SSU72 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSU72 Gene

Proteomics data for SSU72 Gene at MOPED

Post-translational modifications for SSU72 Gene

  • Ubiquitination at Lys 28, Lys 43, and Lys 73
  • Modification sites at PhosphoSitePlus

Other Protein References for SSU72 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SSU72 Gene

Gene Families for SSU72 Gene

Protein Domains for SSU72 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SSU72 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NP77

UniProtKB/Swiss-Prot:

SSU72_HUMAN :
  • Belongs to the SSU72 phosphatase family.
Family:
  • Belongs to the SSU72 phosphatase family.
genes like me logo Genes that share domains with SSU72: view

Function for SSU72 Gene

Molecular function for SSU72 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK.

Enzyme Numbers (IUBMB) for SSU72 Gene

Gene Ontology (GO) - Molecular Function for SSU72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20818333
genes like me logo Genes that share ontologies with SSU72: view
genes like me logo Genes that share phenotypes with SSU72: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSU72 Gene

Localization for SSU72 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSU72 Gene

Nucleus. Cytoplasm. Note=Predominantly in the cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSU72 Gene COMPARTMENTS Subcellular localization image for SSU72 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1
extracellular 1
golgi apparatus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for SSU72 Gene

Pathways & Interactions for SSU72 Gene

genes like me logo Genes that share pathways with SSU72: view

Pathways by source for SSU72 Gene

1 Cell Signaling Technology pathway for SSU72 Gene
1 KEGG pathway for SSU72 Gene

Gene Ontology (GO) - Biological Process for SSU72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006378 mRNA polyadenylation IMP 20861839
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with SSU72: view

No data available for SIGNOR curated interactions for SSU72 Gene

Drugs & Compounds for SSU72 Gene

(2) Additional Compounds for SSU72 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with SSU72: view

Transcripts for SSU72 Gene

Unigene Clusters for SSU72 Gene

SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSU72 Gene

No ASD Table

Relevant External Links for SSU72 Gene

GeneLoc Exon Structure for
SSU72
ECgene alternative splicing isoforms for
SSU72

Expression for SSU72 Gene

mRNA expression in normal human tissues for SSU72 Gene

Protein differential expression in normal tissues from HIPED for SSU72 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSU72 Gene



SOURCE GeneReport for Unigene cluster for SSU72 Gene Hs.549751

genes like me logo Genes that share expression patterns with SSU72: view

Protein tissue co-expression partners for SSU72 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SSU72 Gene

Orthologs for SSU72 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SSU72 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SSU72 35
  • 93.47 (n)
  • 99.48 (a)
-- 36
  • 66 (a)
OneToMany
SSU72 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SSU72 35
  • 92.1 (n)
  • 98.45 (a)
-- 36
  • 93 (a)
OneToMany
SSU72 36
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ssu72 35
  • 90.72 (n)
  • 98.97 (a)
Ssu72 16
Ssu72 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SSU72 35
  • 99.83 (n)
  • 100 (a)
SSU72 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ssu72 35
  • 91.07 (n)
  • 99.48 (a)
oppossum
(Monodelphis domestica)
Mammalia SSU72 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSU72 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves SSU72 35
  • 86.77 (n)
  • 98.97 (a)
SSU72 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSU72 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ssu72 35
  • 79.38 (n)
  • 92.78 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ssu72 35
  • 79.38 (n)
  • 89.18 (a)
ssu72 36
  • 89 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011470 35
  • 66.14 (n)
  • 63.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ssu72 35
  • 61.78 (n)
  • 61.26 (a)
Ssu72 36
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ssup-72 35
  • 57.47 (n)
  • 57.29 (a)
ssup-72 36
  • 55 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL190W 35
  • 53.09 (n)
  • 44.33 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D19514g 35
  • 47.44 (n)
  • 43.96 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSU72 35
  • 50.37 (n)
  • 48.33 (a)
SSU72 36
  • 41 (a)
OneToOne
SSU72 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G73820 35
  • 56.61 (n)
  • 51.85 (a)
soybean
(Glycine max)
eudicotyledons Gma.9639 35
rice
(Oryza sativa)
Liliopsida Os12g0168200 35
  • 57.14 (n)
  • 51.32 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.882 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03114 35
  • 52.01 (n)
  • 48.8 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ssu72 35
  • 49.22 (n)
  • 45.6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
OneToOne
Species with no ortholog for SSU72:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSU72 Gene

ENSEMBL:
Gene Tree for SSU72 (if available)
TreeFam:
Gene Tree for SSU72 (if available)

Paralogs for SSU72 Gene

genes like me logo Genes that share paralogs with SSU72: view

No data available for Paralogs for SSU72 Gene

Variants for SSU72 Gene

Sequence variations from dbSNP and Humsavar for SSU72 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs7533 -- 1,543,953(-) CAGCC(C/T)GTGCA reference, synonymous-codon
rs880050 -- 1,558,367(-) GTTTT(C/G)AGACA intron-variant
rs880051 -- 1,558,347(-) TCTGT(C/T)GTGTG intron-variant
rs1046908 -- 1,564,515(-) GGGTC(C/G/T)TGACA intron-variant
rs1887284 -- 1,551,679(-) GCGTC(C/T)GCGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSU72 Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv10n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
dgv33n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
nsv871837 CNV Loss 21882294
nsv871690 CNV Gain 21882294
essv5472 CNV CNV 17122850
dgv9e1 CNV Complex 17122850
dgv42n71 CNV Loss 21882294
dgv43n71 CNV Loss 21882294
dgv44n71 CNV Gain+Loss 21882294
nsv871954 CNV Loss 21882294
nsv871540 CNV Gain 21882294
dgv45n71 CNV Loss 21882294
esv1301718 CNV Insertion 17803354
esv2747918 CNV Deletion 23290073
esv2748029 CNV Deletion 23290073
esv2675022 CNV Deletion 23128226
esv1010850 CNV Insertion 20482838

Variation tolerance for SSU72 Gene

Residual Variation Intolerance Score: 36.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SSU72 Gene

Disorders for SSU72 Gene

Relevant External Links for SSU72

Genetic Association Database (GAD)
SSU72
Human Genome Epidemiology (HuGE) Navigator
SSU72
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSU72

No disorders were found for SSU72 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSU72 Gene

Publications for SSU72 Gene

  1. Conserved and specific functions of mammalian ssu72. (PMID: 15659578) St Pierre B. … Zacksenhaus E. (Nucleic Acids Res. 2005) 2 3 4 67
  2. Ssu72 Is an RNA polymerase II CTD phosphatase. (PMID: 15125841) Krishnamurthy S. … Hampsey M. (Mol. Cell 2004) 2 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. RNA polymerase II termination involves C-terminal-domain tyrosine dephosphorylation by CPF subunit Glc7. (PMID: 24413056) Schreieck A. … Passmore L.A. (Nat. Struct. Mol. Biol. 2014) 3

Products for SSU72 Gene

Sources for SSU72 Gene

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