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Aliases for SSU72 Gene

Aliases for SSU72 Gene

  • SSU72 Homolog, RNA Polymerase II CTD Phosphatase 2 3 5
  • CTD Phosphatase SSU72 3 4
  • EC 3.1.3.16 4 56
  • SSU72 RNA Polymerase II CTD Phosphatase Homolog (S. Cerevisiae) 2
  • RNA Polymerase II Subunit A C-Terminal Domain Phosphatase SSU72 3
  • Ssu72 RNA Polymerase II CTD Phosphatase Homolog (Yeast) 2
  • PNAS-120 3
  • HSPC182 3

External Ids for SSU72 Gene

Previous GeneCards Identifiers for SSU72 Gene

  • GC01M001563
  • GC01M001466
  • GC01M000757
  • GC01M001477

Summaries for SSU72 Gene

GeneCards Summary for SSU72 Gene

SSU72 (SSU72 Homolog, RNA Polymerase II CTD Phosphatase) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation and mRNA surveillance pathway. Gene Ontology (GO) annotations related to this gene include phosphoprotein phosphatase activity and CTD phosphatase activity. An important paralog of this gene is SSU72P3.

UniProtKB/Swiss-Prot for SSU72 Gene

  • Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK.

Additional gene information for SSU72 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSU72 Gene

Genomics for SSU72 Gene

GeneHancer (GH) Regulatory Elements for SSU72 Gene

Promoters and enhancers for SSU72 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I001573 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 560.4 +0.3 251 3.1 HDGF SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 SSU72 ENSG00000215014 GC01P001575 NOC2L INTS11 ENSG00000240731 ENSG00000230092 ATAD3B MXRA8 FAM87B
GH01I001576 Enhancer 0.6 ENCODE 550.8 -1.4 -1414 0.2 MAFG RFX5 ZNF335 FOSL1 ZNF316 GATA3 JUND FOS EMSY ENSG00000215014 GC01P001575 GC01P001576 SSU72 GC01M001580 GC01M001578
GH01I001539 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 9.2 +34.5 34540 2.3 MXI1 USF1 POLR2A BACH1 SIN3A REST BCL11B TMEM240 ATAD3B SSU72 ENSG00000272512 GC01M001538 ATAD3A
GH01I001397 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 5.7 +174.8 174768 5.5 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 CCNL2 LOC148413 INTS11 ATAD3B ENSG00000240731 LOC100288379 ENSG00000230092 CDK11A SLC35E2 LOC100129381
GH01I001470 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5.1 +103.2 103174 3 ZFP64 ARID4B SIN3A DMAP1 ZNF2 POLR2B ZNF213 E2F8 ZNF143 FOS ATAD3B GC01M001453 CDK11A ENSG00000230092 LOC100288379 ATAD3C ENSG00000237094 RER1 SDF4 CCNL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SSU72 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SSU72 gene promoter:

Genomic Locations for SSU72 Gene

Genomic Locations for SSU72 Gene
chr1:1,541,673-1,574,882
(GRCh38/hg38)
Size:
33,210 bases
Orientation:
Minus strand
chr1:1,477,053-1,510,262
(GRCh37/hg19)

Genomic View for SSU72 Gene

Genes around SSU72 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSU72 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSU72 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSU72 Gene

Proteins for SSU72 Gene

  • Protein details for SSU72 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP77-SSU72_HUMAN
    Recommended name:
    RNA polymerase II subunit A C-terminal domain phosphatase SSU72
    Protein Accession:
    Q9NP77
    Secondary Accessions:
    • Q9BZS6
    • Q9H933

    Protein attributes for SSU72 Gene

    Size:
    194 amino acids
    Molecular mass:
    22574 Da
    Quaternary structure:
    • Interacts with RB1. Interacts with GTF2B and CD226. Interacts with SYMPK.

    Three dimensional structures from OCA and Proteopedia for SSU72 Gene

    Alternative splice isoforms for SSU72 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSU72 Gene

Selected DME Specific Peptides for SSU72 Gene

Q9NP77:
  • PLRVAVVCSSNQNRSMEAHNILSKR
  • DELLQEFEEKS
  • MYNDLLRKD
  • KDKELYTQNGILHMLDRN
  • LGAFLICE
  • KSGRTFLHT
  • TCEERVYD
  • VRSFGTGTHVKLPGPAPDKPN
  • YDFKTTY

Post-translational modifications for SSU72 Gene

  • Ubiquitination at posLast=2828, isoforms=243, and posLast=7373

Other Protein References for SSU72 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SSU72 Gene

Gene Families for SSU72 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for SSU72 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SSU72 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NP77

UniProtKB/Swiss-Prot:

SSU72_HUMAN :
  • Belongs to the SSU72 phosphatase family.
Family:
  • Belongs to the SSU72 phosphatase family.
genes like me logo Genes that share domains with SSU72: view

Function for SSU72 Gene

Molecular function for SSU72 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK.

Enzyme Numbers (IUBMB) for SSU72 Gene

Gene Ontology (GO) - Molecular Function for SSU72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20818333
GO:0008420 CTD phosphatase activity IDA 20861839
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with SSU72: view
genes like me logo Genes that share phenotypes with SSU72: view

miRNA for SSU72 Gene

miRTarBase miRNAs that target SSU72

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSU72 Gene

Localization for SSU72 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSU72 Gene

Nucleus. Cytoplasm. Note=Predominantly in the cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSU72 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
plasma membrane 1
extracellular 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SSU72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex IBA --
genes like me logo Genes that share ontologies with SSU72: view

Pathways & Interactions for SSU72 Gene

genes like me logo Genes that share pathways with SSU72: view

Pathways by source for SSU72 Gene

1 Cell Signaling Technology pathway for SSU72 Gene
1 KEGG pathway for SSU72 Gene

Gene Ontology (GO) - Biological Process for SSU72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006369 termination of RNA polymerase II transcription IBA --
GO:0006378 mRNA polyadenylation IMP 20861839
GO:0006397 mRNA processing IEA --
GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain IDA 20861839
genes like me logo Genes that share ontologies with SSU72: view

No data available for SIGNOR curated interactions for SSU72 Gene

Drugs & Compounds for SSU72 Gene

(2) Drugs for SSU72 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with SSU72: view

Transcripts for SSU72 Gene

Unigene Clusters for SSU72 Gene

SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSU72 Gene

No ASD Table

Relevant External Links for SSU72 Gene

GeneLoc Exon Structure for
SSU72
ECgene alternative splicing isoforms for
SSU72

Expression for SSU72 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSU72 Gene

Protein differential expression in normal tissues from HIPED for SSU72 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SSU72 Gene



Protein tissue co-expression partners for SSU72 Gene

NURSA nuclear receptor signaling pathways regulating expression of SSU72 Gene:

SSU72

SOURCE GeneReport for Unigene cluster for SSU72 Gene:

Hs.549751

Evidence on tissue expression from TISSUES for SSU72 Gene

  • Muscle(4.4)
  • Blood(4.1)
  • Nervous system(3.8)
  • Lung(2.5)
genes like me logo Genes that share expression patterns with SSU72: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSU72 Gene

Orthologs for SSU72 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SSU72 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSU72 34 33
  • 99.83 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSU72 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SSU72 34 33
  • 93.47 (n)
OneToMany
-- 34
  • 66 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 93 (a)
OneToMany
SSU72 34 33
  • 92.1 (n)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ssu72 33
  • 91.07 (n)
mouse
(Mus musculus)
Mammalia Ssu72 16 34 33
  • 90.72 (n)
oppossum
(Monodelphis domestica)
Mammalia SSU72 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SSU72 34 33
  • 86.77 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSU72 34
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ssu72 33
  • 79.38 (n)
zebrafish
(Danio rerio)
Actinopterygii ssu72 33 34
  • 79.38 (n)
-- 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011470 33
  • 66.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ssu72 33 34
  • 61.78 (n)
worm
(Caenorhabditis elegans)
Secernentea ssup-72 33 34
  • 57.47 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL190W 33
  • 53.09 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSU72 33 34 36
  • 50.37 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D19514g 33
  • 47.44 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G73820 33
  • 56.61 (n)
soybean
(Glycine max)
eudicotyledons Gma.9639 33
rice
(Oryza sativa)
Liliopsida Os12g0168200 33
  • 57.14 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 63 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU03114 33
  • 52.01 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ssu72 33
  • 49.22 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.882 33
Species where no ortholog for SSU72 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSU72 Gene

ENSEMBL:
Gene Tree for SSU72 (if available)
TreeFam:
Gene Tree for SSU72 (if available)

Paralogs for SSU72 Gene

Paralogs for SSU72 Gene

genes like me logo Genes that share paralogs with SSU72: view

Variants for SSU72 Gene

Sequence variations from dbSNP and Humsavar for SSU72 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000033034 -- 1,573,494(-) G/A intron_variant
rs1000033620 -- 1,559,802(-) C/T intron_variant
rs1000143929 -- 1,558,293(-) G/C intron_variant
rs1000209096 -- 1,555,670(-) C/A intron_variant
rs1000224402 -- 1,542,576(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SSU72 Gene

Variant ID Type Subtype PubMed ID
dgv8n100 CNV loss 25217958
esv1010850 CNV insertion 20482838
esv1301718 CNV insertion 17803354
esv2675022 CNV deletion 23128226
esv2758913 CNV gain+loss 17122850
esv2760410 CNV gain+loss 21179565
nsv1011818 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1125447 CNV tandem duplication 24896259
nsv1160797 CNV duplication 26073780
nsv472762 CNV novel sequence insertion 20440878
nsv482937 CNV loss 15286789
nsv545000 CNV loss 21841781
nsv950452 CNV deletion 24416366

Variation tolerance for SSU72 Gene

Residual Variation Intolerance Score: 36.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SSU72 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSU72

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSU72 Gene

Disorders for SSU72 Gene

Additional Disease Information for SSU72

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SSU72 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSU72 Gene

Publications for SSU72 Gene

  1. Conserved and specific functions of mammalian ssu72. (PMID: 15659578) St-Pierre B … Zacksenhaus E (Nucleic acids research 2005) 2 3 4 58
  2. An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72. (PMID: 23070812) Xiang K … Tong L (Genes & development 2012) 3 4 58
  3. Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. (PMID: 20861839) Xiang K … Tong L (Nature 2010) 3 4 58
  4. High resolution linkage and linkage disequilibrium analyses of chromosome 1p36 SNPs identify new positional candidate genes for low bone mineral density. (PMID: 18597038) Zhang H … Devoto M (Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2009) 3 44 58
  5. Ssu72 Is an RNA polymerase II CTD phosphatase. (PMID: 15125841) Krishnamurthy S … Hampsey M (Molecular cell 2004) 2 3 58

Products for SSU72 Gene

Sources for SSU72 Gene

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