SSU72 Gene
protein-coding GIFtS: 49
GCID: GC01M001477
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SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)(Previous name: Ssu72 RNA polymerase II CTD phosphatase homolog (yeast)...)
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Aliases
for SSU72 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SSU72 RNA Polymerase II CTD Phosphatase Homolog (S. Cerevisiae)1 2 | | Ssu72 RNA Polymerase II CTD Phosphatase Homolog (Yeast)1 | | HSPC1821 2 | | PNAS-1202 | | CTD Phosphatase SSU722 3 | | RNA Polymerase II Subunit A C-Terminal Domain Phosphatase SSU722 | | EC 3.1.3.163 8 | | |
Export aliases for SSU72 gene to outside databasesPrevious GC identifers: GC01M001563 GC01M001466 GC01M000757 |
Summaries
for SSU72 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SSU72_HUMAN, Q9NP77Function: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Playsa role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK
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Genomic Views
for SSU72 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004350.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SSU72 gene promoter:
AhR TBP ISGF-3 SREBP-1c c-Ets-1 Roaz Arnt SREBP-1b SREBP-1a GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for SSU72
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSU72 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.33 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36SSU72 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M001477: view genomic region
(about GC identifiers)
Start:
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1,477,053 bp from pter |
End:
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1,510,262 bp from pter |
Size:
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33,210 bases |
Orientation:
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minus strand |
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Proteins
for SSU72 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SSU72_HUMAN, Q9NP77 (See
protein sequence)Recommended Name: RNA polymerase II subunit A C-terminal domain phosphatase SSU72 Size: 194 amino acids; 22574 Da
Subunit: Interacts with RB1. Interacts with GTF2B and CD226. Interacts with SYMPK
Subcellular location: Nucleus. Cytoplasm. Note=Predominantly in the cytosol
4 PDB 3D structures from  and Proteopedia  for SSU72:3O2Q (3D)
3O2S (3D)
4H3H (3D)
4H3K (3D)
Secondary accessions: Q9BZS6 Q9H933Alternative splicing: 2 isoforms: Q9NP77-1 Q9NP77-2 Explore the universe of human proteins at neXtProt for SSU72: NX_Q9NP77
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NP77
4/9 DME Specific Peptides for SSU72 (Q9NP77) (see all 9)
SSU72 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_054907.1
ENSEMBL proteins: ENSP00000291386 ENSP00000351955
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SSU72 for ontologies About GeneDecksing
SSU72 Antibody Products:
Assay Products for SSU72: |
Protein
Domains /
Families
for SSU72 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SSU72 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NP77ProtoNet protein and cluster: Q9NP77 UniProtKB/Swiss-Prot: SSU72_HUMAN, Q9NP77Similarity: Belongs to the SSU72 phosphatase family |
Function
for SSU72 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SSU72_HUMAN, Q9NP77Function: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Playsa role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPKCatalytic activity: A phosphoprotein + H(2)O = a protein + phosphateEnzyme Number (IUBMB): EC 3.1.3.161 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSU72 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSU72
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SSU72 (NM_014188) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SSU72 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSU72 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSU72 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004721 | phosphoprotein phosphatase activity |
-- | -- | | GO:0008420 | CTD phosphatase activity |
IDA | -- |
SSU72 for ontologies About GeneDecksing
|
Pathways & Interactions
for SSU72 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SSU72
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
5/79 Interacting proteins for SSU72 (Q9NP772, 3 ENSP000002913864) via UniProtKB, MINT, STRING, and/or I2D (see all 79)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006378 | mRNA polyadenylation |
IMP | -- | | GO:0006397 | mRNA processing |
-- | -- | | GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain |
IDA | -- |
SSU72 for ontologies About GeneDecksing
|
Drugs & Compounds
for SSU72 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SSU72
1 HMDB Compound for SSU72 About this table
Search CenterWatch for drugs/clinical trials and news about SSU72
|
Transcripts
for SSU72 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SSU72 gene: NM_014188.2 Unigene Cluster for SSU72: SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) Hs.549751 [show with all ESTs]Unigene Representative Sequence: AK0231104 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000291386(uc001agd.3 uc009vkg.1) ENST00000378726 ENST00000378725
ENST00000359060(uc001age.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSU72 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSU72
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SSU72 (NM_014188) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SSU72 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSU72 |
Additional cDNA sequence: AB593172.1 AF161530.1 AF277178.1 AJ276409.1 AK001809.1 AK023110.1 AK127149.1 AK297505.1 AK310067.1 BC008070.2 BC018909.2 15 DOTS entries: DT.75119083 DT.100711154 DT.312838 DT.100819158 DT.121421659 DT.100744110 DT.121421713 DT.102839757 DT.97854164 DT.87078440 DT.91756632 DT.95209542 DT.99965663 DT.121421656 DT.95209543 24/429 AceView cDNA sequences (see all 429): CR591269 CB529309 BQ229353 AI300423 AW590204 CB178780 AA348928 BM915409 BF437257 CB850775 AA642661 AI301586 BQ778520 AW341328 BU501801 AI264533 AK127149 BQ053410 CB054519 Z40614 AW027536 AA298641 AW675515 AA911419
GeneLoc Exon Structure
|
Expression
for SSU72 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SSU72 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCCGCCTC
About this image
See SSU72 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SSU72
SOURCE GeneReport for Unigene cluster: Hs.549751
SABiosciences Expression via Pathway-Focused PCR Array including SSU72:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SSU72
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SSU72 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSU72 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSU72 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSU72 |
Orthologs
for SSU72 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SSU72 gene from 10/34 species (see all 34) About this table
ENSEMBL Gene Tree for SSU72 (if available)
TreeFam Gene Tree for SSU72 (if available) |
Paralogs
for SSU72 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SSU72 gene
SSU72 for paralogs About GeneDecksing
5/8 Pseudogenes.org Pseudogenes for SSU72 (see all 8)
PGOHUM00000257797 PGOHUM00000257798 PGOHUM00000257799 PGOHUM00000257868 PGOHUM00000242562
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Genomic Variants
for SSU72 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SSU72 (1477053 - 1510262 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for SSU72
4 CNVs: 2042 2295 30362 3276 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSU72 |
|
Disorders
/ Diseases
for SSU72 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SSU72 for disorders About MalaCards
SSU72 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: SSU72 (1 document)
Export disorders for SSU72 gene to outside databases
|
Publications
for SSU72 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SSU72 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with SSU72) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Conserved and specific functions of mammalian ssu72. (PubMed id 15659578)1, 2, 3 St Pierre B....Zacksenhaus E. (2005)
- An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72. (PubMed id 23070812)1, 2 Xiang K.... Tong L. (2012)
- Crystal structure of the human symplekin-Ssu72-CTD ph osphopeptide complex. (PubMed id 20861839)1, 2 Xiang K....Tong L. (2010)
- Ssu72 Is an RNA polymerase II CTD phosphatase. (PubMed id 15125841)1, 3 Krishnamurthy S....Hampsey M. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
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External Searches for SSU72 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SSU72 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SSU72 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SSU72 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SSU72 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SSU72 gene:
Search GeneIP for patents involving SSU72
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SSU72 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SSU72 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SSU72 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SSU72 | | | OriGene Protein Over-expression Lysate for SSU72 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SSU72 | | OriGene 3'-UTR Clone for SSU72 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSU72 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSU72 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SSU72 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SSU72 | | OriGene Custom Protein Services for SSU72 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SSU72 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSU72 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSU72 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSU72 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSU72 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSU72 |
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 |  |  |  | |
| | | | Search Tocris compounds for SSU72 |
| |  |  |  |  | | | | | | Recombinant Protein for SSU72 |
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 | | | SSU72 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSU72 |
|  |  |  | | | | ThermoFisher Antibodies for SSU72 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSU72 |
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