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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SSU72 Gene

protein-coding   GIFtS: 52
GCID: GC01M001477

SSU72 RNA Polymerase II CTD Phosphatase Homolog (S. Cerevisiae)

(Previous name: Ssu72 RNA polymerase II CTD phosphatase homolog (yeast))
  Search for SSU72
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SSU72 RNA Polymerase II CTD Phosphatase Homolog (S. Cerevisiae)1 2     HSPC1822
CTD Phosphatase SSU722 3     PNAS-1202
EC 3.1.3.163 8     RNA Polymerase II Subunit A C-Terminal Domain Phosphatase SSU722
Ssu72 RNA Polymerase II CTD Phosphatase Homolog (Yeast)1     

External Ids:    HGNC: 250161   Entrez Gene: 291012   Ensembl: ENSG000001600757   UniProtKB: Q9NP773   

Export aliases for SSU72 gene to outside databases

Previous GC identifers: GC01M001563 GC01M001466 GC01M000757


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SSU72 Gene: 
SSU72 (SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include CTD phosphatase activity.

UniProtKB/Swiss-Prot: SSU72_HUMAN, Q9NP77
Function: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II.
Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with
SYMPK




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004350.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SSU72 gene promoter:
         AhR   TBP   ISGF-3   SREBP-1c   c-Ets-1   Roaz   Arnt   SREBP-1b   SREBP-1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSSU72 promoter sequence
   Search SABiosciences Chromatin IP Primers for SSU72

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSU72


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36

SSU72 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSU72 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001477:  view genomic region     (about GC identifiers)

Start:
1,477,053 bp from pter      End:
1,510,262 bp from pter
Size:
33,210 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SSU72_HUMAN, Q9NP77 (See protein sequence)
Recommended Name: RNA polymerase II subunit A C-terminal domain phosphatase SSU72  
Size: 194 amino acids; 22574 Da
Subunit: Interacts with RB1. Interacts with GTF2B and CD226. Interacts with SYMPK
Subcellular location: Nucleus. Cytoplasm. Note=Predominantly in the cytosol
4 PDB 3D structures from and Proteopedia for SSU72:
3O2Q (3D)        3O2S (3D)        4H3H (3D)        4H3K (3D)    
Secondary accessions: Q9BZS6 Q9H933
Alternative splicing: 2 isoforms:  Q9NP77-1   Q9NP77-2   

Explore the universe of human proteins at neXtProt for SSU72: NX_Q9NP77

Explore proteomics data for SSU72 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NP77

  • 4/9 DME Specific Peptides for SSU72 (Q9NP77) (see all 9)
     YDFKTTY  LGAFLICE  TCEERVYD  KSGRTFLHT 

    SSU72 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SSU72 Protein Expression
    REFSEQ proteins: NP_054907.1  
    ENSEMBL proteins: 
     ENSP00000291386   ENSP00000351955  

    Human Recombinant Protein Products for SSU72: 
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    OriGene Protein Over-expression Lysate for SSU72
    OriGene MassSpec for SSU72 
    OriGene Custom Protein Services for SSU72
    GenScript Custom Purified and Recombinant Proteins Services for SSU72
    Novus Biologicals SSU72 Proteins
    Novus Biologicals SSU72 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SSU72
    Cloud-Clone Corp. Proteins for SSU72 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    SSU72 for ontologies           About GeneDecksing



    SSU72 Antibody Products: 
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    ThermoFisher Antibodies for SSU72
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    Assay Products for SSU72: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SSU72 
    Cloud-Clone Corp. CLIAs for SSU72


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR006811 RNA_pol_II_suA

    Graphical View of Domain Structure for InterPro Entry Q9NP77

    ProtoNet protein and cluster: Q9NP77

    UniProtKB/Swiss-Prot: SSU72_HUMAN, Q9NP77
    Similarity: Belongs to the SSU72 phosphatase family


    SSU72 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSU72_HUMAN, Q9NP77
    Function: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II.
    Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with
    SYMPK
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

         Enzyme Number (IUBMB): EC 3.1.3.161 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0005515protein binding IPI--
    GO:0008420CTD phosphatase activity IDA--
         
    SSU72 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SSU72 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SSU72

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SSU72 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SSU72 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSU72
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SSU72:
    hsa-miR-548d-3p hsa-miR-548am hsa-miR-548x hsa-miR-1252 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidSSU72 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SSU72
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSU72

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SSU72

    Clone
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    OriGene clones in human, mouse for SSU72 (see all 8)
    OriGene ORF clones in mouse, rat for SSU72
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SSU72 (NM_014188)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSU72
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSU72
    Sirion Biotech Customized lentivirus for stable overexpression of SSU72 
                         Customized lentivirus expression plasmids for stable overexpression of SSU72 

    Cell Line
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    Search LifeMap BioReagents cell lines for SSU72
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSU72


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SSU72 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA surveillance pathway
    mRNA surveillance pathway
    2Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SSU72
        Chromatin Regulation / Acetylation


    1         Kegg Pathway  (Kegg details for SSU72):
        mRNA surveillance pathway


    SSU72 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SSU72

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/79 Interacting proteins for SSU72 (Q9NP772, 3 ENSP000002913864) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAD21O602162, 3, ENSP000002973384MINT-8081286 MINT-8081321 MINT-8081344 MINT-8081406 MINT-8080160 MINT-8081393 MINT-8081303 MINT-8081377 MINT-8080156 I2D: score=2 STRING: ENSP00000297338
    SMC3Q9UQE72, 3, ENSP000003547204MINT-8081286 MINT-8081321 MINT-8080160 MINT-8081303 I2D: score=1 STRING: ENSP00000354720
    SMC1AQ146832, 3, ENSP000003234214MINT-8081321 MINT-8080160 MINT-8081303 I2D: score=1 STRING: ENSP00000323421
    STAG2Q8N3U42, 3, ENSP000002180894MINT-8081286 MINT-8081321 MINT-8080160 MINT-8081365 MINT-8081377 I2D: score=2 STRING: ENSP00000218089
    SYMPKQ927973, ENSP000002459344I2D: score=4 STRING: ENSP00000245934
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006378mRNA polyadenylation IMP--
    GO:0006397mRNA processing ----
    GO:0070940dephosphorylation of RNA polymerase II C-terminal domain IDA--

    SSU72 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SSU72

    1 HMDB Compound for SSU72    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--

    Search CenterWatch for drugs/clinical trials and news about SSU72

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SSU72 gene: 
    NM_014188.2  

    Unigene Cluster for SSU72:

    SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)
    Hs.549751  [show with all ESTs]
    Unigene Representative Sequence: AK023110
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000291386(uc001agd.3 uc009vkg.1) ENST00000378726 ENST00000378725
    ENST00000359060(uc001age.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSU72
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SSU72:
    hsa-miR-548d-3p hsa-miR-548am hsa-miR-548x hsa-miR-1252 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidSSU72 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SSU72
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSU72
    Clone
    Products:
         
    OriGene clones in human, mouse for SSU72 (see all 8)
    OriGene ORF clones in mouse, rat for SSU72
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SSU72 (NM_014188)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSU72
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSU72
    Sirion Biotech Customized lentivirus for stable overexpression of SSU72 
                         Customized lentivirus expression plasmids for stable overexpression of SSU72 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SSU72
    OriGene qSTAR qPCR primer pairs in human, mouse for SSU72
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SSU72
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSU72
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSU72

    Additional mRNA sequence: 

    AB593172.1 AF161530.1 AF277178.1 AJ276409.1 AK001809.1 AK023110.1 AK127149.1 AK297505.1 
    AK310067.1 BC008070.2 BC018909.2 

    15 DOTS entries:

    DT.75119083  DT.100711154  DT.312838  DT.100819158  DT.121421659  DT.100744110  DT.121421713  DT.102839757 
    DT.97854164  DT.87078440  DT.91756632  DT.95209542  DT.99965663  DT.121421656  DT.95209543 

    24/429 AceView cDNA sequences (see all 429):

    BQ182018 AW675515 AW439071 BG777951 BM129391 AK127149 AI700968 AA064925 
    BM695377 AI457365 BU949770 AA741489 AA203523 CA866759 BF437797 AJ276409 
    AI769430 BU849220 CB529309 AI168033 BX497000 BM670154 BE464383 BQ774740 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SSU72 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCCGCCTC
    SSU72 Expression
    About this image


    See SSU72 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SSU72

    SOURCE GeneReport for Unigene cluster: Hs.549751
        SABiosciences Expression via Pathway-Focused PCR Array including SSU72: 
              Protein Phosphatases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SSU72
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSU72
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSU72

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SSU72 gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ssu721 , 5 Ssu72 RNA polymerase II CTD phosphatase homolog (yeast)1, 5 90.72(n)1
    98.97(a)1
      4 (87.07 cM)5
    689911  NM_026899.31  NP_081175.21 
     1557048005 
    chicken
    (Gallus gallus)
    Aves SSU721 SSU72 RNA polymerase II CTD phosphatase homolog (S. more 86.77(n)
    98.97(a)
      419410  NM_001007875.1  NP_001007876.1 
    lizard
    (Anolis carolinensis)
    Reptilia SSU726
    Uncharacterized protein
    98(a)
    1 ↔ 1
    GL344201.1(7875-43825)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX848863.12   -- 78.58(n)    BX848863.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059504.12   -- 80.43(n)   393701  BC059504.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG142161 CG14216 61.78(n)
    61.26(a)
      32973  NM_134498.2  NP_608342.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ssup-721 Protein SSUP-72 57.64(n)
    57.29(a)
      188472  NM_062985.3  NP_495386.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSU72(YNL222W)4
    SSU721
    Transcription/RNA-processing factor that associates more4
    Ssu72p1
    50.37(n)1
    48.33(a)1
      14(229094-229714)4
    8554991, 4  NP_014177.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G738201 Ssu72-like protein 56.74(n)
    52.13(a)
      843718  NM_106042.2  NP_177523.1 
    rice
    (Oryza sativa)
    Liliopsida AK069543.12   -- 74.29(n)    AK069543.1 


    ENSEMBL Gene Tree for SSU72 (if available)
    TreeFam Gene Tree for SSU72 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SSU72 gene

    SSU72 for paralogs           About GeneDecksing


    5/8 Pseudogenes.org Pseudogenes for SSU72 (see all 8)
    PGOHUM00000257797 PGOHUM00000257798 PGOHUM00000257799 PGOHUM00000257868 PGOHUM00000242562


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/846 SNPs in SSU72 are shown (see all 846)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1833577361,2
    --1477863(+) ACAGCA/GGGGCC 1 -- int10--------
    rs1865630091,2
    --1477987(+) CCAGAC/GTGAGC 1 -- int10--------
    rs37661801,2
    C,F,A,H--1478153(-) ATTGCG/ACGATT 1 -- int137Minor allele frequency- A:0.29NS EA NA WA CSA 3566
    rs37661791,2
    C,F,A,H--1478173(-) AAAATC/GTCGTC 1 -- int19Minor allele frequency- G:0.32NA WA CSA EA 372
    rs37661781,2
    C,F,A,H--1478180(-) TCATAG/AGAAAA 1 -- int123Minor allele frequency- A:0.29NS EA NA WA CSA 2354
    rs1897616271,2
    --1478247(+) TGGACC/TGTGAG 1 -- int10--------
    rs767566591,2
    F--1478380(+) TCTTTC/TTTGGT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1456117931,2
    C--1478690(+) GCACCA/GCATCC 1 -- int10--------
    rs556944631,2
    C--1478694(+) CGCATC/GCCGGA 1 -- int10--------
    rs66659731,2
    C,F--1478880(+) AGCTGG/TGGAGT 1 -- int18Minor allele frequency- T:0.32NA WA EA 368

    HapMap Linkage Disequilibrium report for SSU72 (1477053 - 1510262 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for SSU72 (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748029CNV Deletion23290073
    esv2675022CNV Deletion23128226
    esv2747918CNV Deletion23290073
    esv1010850CNV Insertion20482838
    esv1301718CNV Insertion17803354
    nsv871954CNV Loss21882294
    dgv42n71CNV Loss21882294
    dgv10n71CNV Loss21882294
    dgv34n71CNV Loss21882294
    nsv871837CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SSU72 for disorders           About MalaCards

    SSU72 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SSU72
    Human Genome Epidemiology (HuGE) Navigator: SSU72 (1 document)

    Export disorders for SSU72 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SSU72 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with SSU72)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Conserved and specific functions of mammalian ssu72. (PubMed id 15659578)1, 2, 3 St Pierre B....Zacksenhaus E. (2005)
    2. An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72. (PubMed id 23070812)1, 2 Xiang K.... Tong L. (2012)
    3. Crystal structure of the human symplekin-Ssu72-CTD ph osphopeptide complex. (PubMed id 20861839)1, 2 Xiang K....Tong L. (2010)
    4. High resolution linkage and linkage disequilibrium analyses of chromosome 1p36 SNPs identify new positional candidate genes for low bone mineral density. (PubMed id 18597038)1, 4 Zhang H....Devoto M. (2008)
    5. Ssu72 Is an RNA polymerase II CTD phosphatase. (PubMed id 15125841)1, 3 Krishnamurthy S....Hampsey M. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29101 HGNC: 25016 AceView: HSPC182 Ensembl:ENSG00000160075 euGenes: HUgn29101
    ECgene: SSU72 Kegg: 29101 H-InvDB: SSU72

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SSU72 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SSU72 gene:
    Search GeneIP for patents involving SSU72

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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