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Aliases for SSU72 Gene

Aliases for SSU72 Gene

  • SSU72 Homolog, RNA Polymerase II CTD Phosphatase 2 3 5
  • CTD Phosphatase SSU72 3 4
  • EC 3.1.3.16 4 61
  • SSU72 RNA Polymerase II CTD Phosphatase Homolog (S. Cerevisiae) 2
  • RNA Polymerase II Subunit A C-Terminal Domain Phosphatase SSU72 3
  • Ssu72 RNA Polymerase II CTD Phosphatase Homolog (Yeast) 2
  • PNAS-120 3
  • HSPC182 3

External Ids for SSU72 Gene

Previous GeneCards Identifiers for SSU72 Gene

  • GC01M001563
  • GC01M001466
  • GC01M000757
  • GC01M001477

Summaries for SSU72 Gene

GeneCards Summary for SSU72 Gene

SSU72 (SSU72 Homolog, RNA Polymerase II CTD Phosphatase) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway and Chromatin Regulation / Acetylation. GO annotations related to this gene include phosphoprotein phosphatase activity and CTD phosphatase activity.

UniProtKB/Swiss-Prot for SSU72 Gene

  • Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSU72 Gene

Genomics for SSU72 Gene

Regulatory Elements for SSU72 Gene

Enhancers for SSU72 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F001573 0.6 ENCODE 10.4 +0.3 252 3.1 HDGF ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CBX5 LINC01770 NOC2L ENSG00000230092 LOC100288379 CDK11B MIR6727 ENSG00000240731 SSU72 CCNL2 ENSG00000215014
GH01F001550 0.5 ENCODE 10.2 +23.6 23559 1.9 CTCF RFX1 ZIC2 RAD21 NR2F2 GLIS2 ZBTB48 GLIS1 ZBTB33 ZNF600 ATAD3B SSU72 ATAD3C GC01M001538 TMEM240
GH01F001542 1.3 Ensembl ENCODE 10.1 +31.4 31356 1.3 HDGF KLF1 SAP130 HIC1 GLIS2 ZFHX2 POLR2A GLIS1 KLF9 ZBTB33 SSU72 ANKRD65 TMEM240 GC01M001538
GH01F001566 1.2 Ensembl ENCODE 10 +7.1 7053 2.1 ZNF121 ZNF384 ZNF391 TRIM28 LINC01770 VWA1 SSU72 MTND1P23 GC01P001570 PIR50490
GH01F001554 0.2 ENCODE 9.9 +19.7 19734 1.6 KLF1 PKNOX1 JUN INSM2 KLF17 RFX5 ZFHX2 GLIS2 ZBTB48 POLR2A LINC01770 VWA1 SSU72 GC01M001538 PIR34017
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SSU72 on UCSC Golden Path with GeneCards custom track

Promoters for SSU72 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000529025 382 3001 HDGF ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143

Genomic Location for SSU72 Gene

Chromosome:
1
Start:
1,541,673 bp from pter
End:
1,574,882 bp from pter
Size:
33,210 bases
Orientation:
Minus strand

Genomic View for SSU72 Gene

Genes around SSU72 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSU72 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSU72 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSU72 Gene

Proteins for SSU72 Gene

  • Protein details for SSU72 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP77-SSU72_HUMAN
    Recommended name:
    RNA polymerase II subunit A C-terminal domain phosphatase SSU72
    Protein Accession:
    Q9NP77
    Secondary Accessions:
    • Q9BZS6
    • Q9H933

    Protein attributes for SSU72 Gene

    Size:
    194 amino acids
    Molecular mass:
    22574 Da
    Quaternary structure:
    • Interacts with RB1. Interacts with GTF2B and CD226. Interacts with SYMPK.

    Three dimensional structures from OCA and Proteopedia for SSU72 Gene

    Alternative splice isoforms for SSU72 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSU72 Gene

Selected DME Specific Peptides for SSU72 Gene

Q9NP77:
  • PLRVAVVCSSNQNRSMEAHNILSKR
  • DELLQEFEEKS
  • MYNDLLRKD
  • KDKELYTQNGILHMLDRN
  • LGAFLICE
  • KSGRTFLHT
  • TCEERVYD
  • VRSFGTGTHVKLPGPAPDKPN
  • YDFKTTY

Post-translational modifications for SSU72 Gene

  • Ubiquitination at Lys 28, Lys 43, and Lys 73
  • Modification sites at PhosphoSitePlus

Other Protein References for SSU72 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SSU72 Gene

Gene Families for SSU72 Gene

Protein Domains for SSU72 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SSU72 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NP77

UniProtKB/Swiss-Prot:

SSU72_HUMAN :
  • Belongs to the SSU72 phosphatase family.
Family:
  • Belongs to the SSU72 phosphatase family.
genes like me logo Genes that share domains with SSU72: view

Function for SSU72 Gene

Molecular function for SSU72 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK.

Enzyme Numbers (IUBMB) for SSU72 Gene

Gene Ontology (GO) - Molecular Function for SSU72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20818333
GO:0008420 CTD phosphatase activity IDA 20861839
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with SSU72: view
genes like me logo Genes that share phenotypes with SSU72: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSU72 Gene

Localization for SSU72 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSU72 Gene

Nucleus. Cytoplasm. Note=Predominantly in the cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSU72 Gene COMPARTMENTS Subcellular localization image for SSU72 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1
extracellular 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SSU72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex IBA --
genes like me logo Genes that share ontologies with SSU72: view

Pathways & Interactions for SSU72 Gene

genes like me logo Genes that share pathways with SSU72: view

Pathways by source for SSU72 Gene

1 Cell Signaling Technology pathway for SSU72 Gene
1 KEGG pathway for SSU72 Gene

Gene Ontology (GO) - Biological Process for SSU72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006369 termination of RNA polymerase II transcription IBA --
GO:0006378 mRNA polyadenylation IMP 20861839
GO:0006397 mRNA processing IEA --
GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain IDA 20861839
genes like me logo Genes that share ontologies with SSU72: view

No data available for SIGNOR curated interactions for SSU72 Gene

Drugs & Compounds for SSU72 Gene

(2) Drugs for SSU72 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with SSU72: view

Transcripts for SSU72 Gene

Unigene Clusters for SSU72 Gene

SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSU72 Gene

No ASD Table

Relevant External Links for SSU72 Gene

GeneLoc Exon Structure for
SSU72
ECgene alternative splicing isoforms for
SSU72

Expression for SSU72 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SSU72 Gene

Protein differential expression in normal tissues from HIPED for SSU72 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SSU72 Gene



Protein tissue co-expression partners for SSU72 Gene

NURSA nuclear receptor signaling pathways regulating expression of SSU72 Gene:

SSU72

SOURCE GeneReport for Unigene cluster for SSU72 Gene:

Hs.549751
genes like me logo Genes that share expression patterns with SSU72: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SSU72 Gene

Orthologs for SSU72 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SSU72 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSU72 34 35
  • 99.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SSU72 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SSU72 34 35
  • 93.47 (n)
-- 35
  • 66 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 93 (a)
OneToMany
SSU72 34 35
  • 92.1 (n)
rat
(Rattus norvegicus)
Mammalia Ssu72 34
  • 91.07 (n)
mouse
(Mus musculus)
Mammalia Ssu72 34 16 35
  • 90.72 (n)
oppossum
(Monodelphis domestica)
Mammalia SSU72 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SSU72 34 35
  • 86.77 (n)
lizard
(Anolis carolinensis)
Reptilia SSU72 35
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ssu72 34
  • 79.38 (n)
zebrafish
(Danio rerio)
Actinopterygii ssu72 34 35
  • 79.38 (n)
-- 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011470 34
  • 66.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ssu72 34 35
  • 61.78 (n)
worm
(Caenorhabditis elegans)
Secernentea ssup-72 34 35
  • 57.47 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL190W 34
  • 53.09 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSU72 34 35 37
  • 50.37 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D19514g 34
  • 47.44 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G73820 34
  • 56.61 (n)
soybean
(Glycine max)
eudicotyledons Gma.9639 34
rice
(Oryza sativa)
Liliopsida Os12g0168200 34
  • 57.14 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 63 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU03114 34
  • 52.01 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ssu72 34
  • 49.22 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.882 34
Species where no ortholog for SSU72 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSU72 Gene

ENSEMBL:
Gene Tree for SSU72 (if available)
TreeFam:
Gene Tree for SSU72 (if available)

Paralogs for SSU72 Gene

No data available for Paralogs for SSU72 Gene

Variants for SSU72 Gene

Sequence variations from dbSNP and Humsavar for SSU72 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10157217 -- 1,558,570(+) GCTAC(A/C)CGTTT intron-variant
rs10158997 -- 1,558,752(+) TGTCT(G/T)CCACC intron-variant
rs1046842 -- 1,541,841(-) TTTTT(C/T)TTCTT upstream-variant-2KB, utr-variant-3-prime
rs1046878 -- 1,541,728(-) GAGCC(C/T)TGCTG upstream-variant-2KB, utr-variant-3-prime
rs1046908 -- 1,564,515(-) GGGTC(C/G/T)TGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSU72 Gene

Variant ID Type Subtype PubMed ID
dgv8n100 CNV loss 25217958
esv1010850 CNV insertion 20482838
esv1301718 CNV insertion 17803354
esv2675022 CNV deletion 23128226
esv2758913 CNV gain+loss 17122850
esv2760410 CNV gain+loss 21179565
nsv1011818 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1125447 CNV tandem duplication 24896259
nsv1160797 CNV duplication 26073780
nsv472762 CNV novel sequence insertion 20440878
nsv482937 CNV loss 15286789
nsv545000 CNV loss 21841781
nsv950452 CNV deletion 24416366

Variation tolerance for SSU72 Gene

Residual Variation Intolerance Score: 36.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSU72 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSU72

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSU72 Gene

Disorders for SSU72 Gene

Relevant External Links for SSU72

Genetic Association Database (GAD)
SSU72
Human Genome Epidemiology (HuGE) Navigator
SSU72
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSU72

No disorders were found for SSU72 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSU72 Gene

Publications for SSU72 Gene

  1. Conserved and specific functions of mammalian ssu72. (PMID: 15659578) St Pierre B. … Zacksenhaus E. (Nucleic Acids Res. 2005) 2 3 4 64
  2. An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72. (PMID: 23070812) Xiang K. … Tong L. (Genes Dev. 2012) 3 4 64
  3. Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. (PMID: 20861839) Xiang K. … Tong L. (Nature 2010) 3 4 64
  4. High resolution linkage and linkage disequilibrium analyses of chromosome 1p36 SNPs identify new positional candidate genes for low bone mineral density. (PMID: 18597038) Zhang H. … Devoto M. (Osteoporos Int 2009) 3 46 64
  5. Ssu72 Is an RNA polymerase II CTD phosphatase. (PMID: 15125841) Krishnamurthy S. … Hampsey M. (Mol. Cell 2004) 2 3 64

Products for SSU72 Gene

Sources for SSU72 Gene

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