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Aliases for SSU72 Gene

Aliases for SSU72 Gene

  • SSU72 RNA Polymerase II CTD Phosphatase Homolog (S. Cerevisiae) 2 3
  • CTD Phosphatase SSU72 3 4
  • EC 3.1.3.16 4 63
  • RNA Polymerase II Subunit A C-Terminal Domain Phosphatase SSU72 3
  • Ssu72 RNA Polymerase II CTD Phosphatase Homolog (Yeast) 2
  • PNAS-120 3
  • HSPC182 3

External Ids for SSU72 Gene

Previous GeneCards Identifiers for SSU72 Gene

  • GC01M001563
  • GC01M001466
  • GC01M000757
  • GC01M001477

Summaries for SSU72 Gene

GeneCards Summary for SSU72 Gene

SSU72 (SSU72 RNA Polymerase II CTD Phosphatase Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation and mRNA surveillance pathway. GO annotations related to this gene include CTD phosphatase activity.

UniProtKB/Swiss-Prot for SSU72 Gene

  • Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSU72 Gene

Genomics for SSU72 Gene

Regulatory Elements for SSU72 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SSU72 Gene

Start:
1,541,673 bp from pter
End:
1,574,882 bp from pter
Size:
33,210 bases
Orientation:
Minus strand

Genomic View for SSU72 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSU72 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSU72 Gene

Proteins for SSU72 Gene

  • Protein details for SSU72 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP77-SSU72_HUMAN
    Recommended name:
    RNA polymerase II subunit A C-terminal domain phosphatase SSU72
    Protein Accession:
    Q9NP77
    Secondary Accessions:
    • Q9BZS6
    • Q9H933

    Protein attributes for SSU72 Gene

    Size:
    194 amino acids
    Molecular mass:
    22574 Da
    Quaternary structure:
    • Interacts with RB1. Interacts with GTF2B and CD226. Interacts with SYMPK.

    Three dimensional structures from OCA and Proteopedia for SSU72 Gene

    Alternative splice isoforms for SSU72 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSU72 Gene

Proteomics data for SSU72 Gene at MOPED

Post-translational modifications for SSU72 Gene

  • Ubiquitination at Lys28, Lys43, and Lys73
  • Modification sites at PhosphoSitePlus

Other Protein References for SSU72 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for SSU72 Gene

Protein Domains for SSU72 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SSU72 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NP77

UniProtKB/Swiss-Prot:

SSU72_HUMAN :
  • Q9NP77
Family:
  • Belongs to the SSU72 phosphatase family.
genes like me logo Genes that share domains with SSU72: view

No data available for Gene Families for SSU72 Gene

Function for SSU72 Gene

Molecular function for SSU72 Gene

UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK.

Enzyme Numbers (IUBMB) for SSU72 Gene

Gene Ontology (GO) - Molecular Function for SSU72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity --
GO:0005515 protein binding IPI 20818333
GO:0008420 CTD phosphatase activity IDA 20861839
genes like me logo Genes that share ontologies with SSU72: view

Animal Model Products

CRISPR Products

miRNA for SSU72 Gene

miRTarBase miRNAs that target SSU72

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSU72

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SSU72 Gene

Localization for SSU72 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSU72 Gene

Nucleus. Cytoplasm. Note=Predominantly in the cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSU72 Gene COMPARTMENTS Subcellular localization image for SSU72 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1
extracellular 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SSU72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SSU72: view

Pathways for SSU72 Gene

genes like me logo Genes that share pathways with SSU72: view

Pathways by source for SSU72 Gene

1 Cell Signaling Technology pathway for SSU72 Gene
1 KEGG pathway for SSU72 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SSU72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006378 mRNA polyadenylation IMP 20861839
GO:0006397 mRNA processing --
GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain IDA 20861839
genes like me logo Genes that share ontologies with SSU72: view

Compounds for SSU72 Gene

(1) HMDB Compounds for SSU72 Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2
genes like me logo Genes that share compounds with SSU72: view

Transcripts for SSU72 Gene

Unigene Clusters for SSU72 Gene

SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSU72

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSU72 Gene

No ASD Table

Relevant External Links for SSU72 Gene

GeneLoc Exon Structure for
SSU72
ECgene alternative splicing isoforms for
SSU72

Expression for SSU72 Gene

mRNA expression in normal human tissues for SSU72 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSU72 Gene

SOURCE GeneReport for Unigene cluster for SSU72 Gene Hs.549751

genes like me logo Genes that share expressions with SSU72: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SSU72 Gene

Orthologs for SSU72 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SSU72 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSU72 35
  • 99.83 (n)
  • 100 (a)
SSU72 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 66 (a)
OneToMany
SSU72 35
  • 93.47 (n)
  • 99.48 (a)
SSU72 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 93 (a)
OneToMany
SSU72 35
  • 92.1 (n)
  • 98.45 (a)
SSU72 36
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ssu72 35
  • 90.72 (n)
  • 98.97 (a)
Ssu72 16
Ssu72 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SSU72 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSU72 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ssu72 35
  • 91.07 (n)
  • 99.48 (a)
chicken
(Gallus gallus)
Aves SSU72 35
  • 86.77 (n)
  • 98.97 (a)
SSU72 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSU72 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ssu72 35
  • 79.38 (n)
  • 92.78 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ssu72 35
  • 79.38 (n)
  • 89.18 (a)
ssu72 36
  • 89 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011470 35
  • 66.14 (n)
  • 63.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ssu72 35
  • 61.78 (n)
  • 61.26 (a)
Ssu72 36
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ssup-72 35
  • 57.47 (n)
  • 57.29 (a)
ssup-72 36
  • 55 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL190W 35
  • 53.09 (n)
  • 44.33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSU72 35
  • 50.37 (n)
  • 48.33 (a)
SSU72 36
  • 41 (a)
OneToOne
SSU72 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D19514g 35
  • 47.44 (n)
  • 43.96 (a)
soybean
(Glycine max)
eudicotyledons Gma.9639 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G73820 35
  • 56.61 (n)
  • 51.85 (a)
rice
(Oryza sativa)
Liliopsida Os12g0168200 35
  • 57.14 (n)
  • 51.32 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03114 35
  • 52.01 (n)
  • 48.8 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ssu72 35
  • 49.22 (n)
  • 45.6 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.882 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
OneToOne
Species with no ortholog for SSU72:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSU72 Gene

ENSEMBL:
Gene Tree for SSU72 (if available)
TreeFam:
Gene Tree for SSU72 (if available)

Paralogs for SSU72 Gene

genes like me logo Genes that share paralogs with SSU72: view

No data available for Paralogs for SSU72 Gene

Variants for SSU72 Gene

Sequence variations from dbSNP and Humsavar for SSU72 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7533 -- 1,543,953(-) CAGCC(C/T)GTGCA synonymous-codon, reference
rs880050 -- 1,558,367(-) GTTTT(C/G)AGACA intron-variant
rs880051 -- 1,558,347(-) TCTGT(C/T)GTGTG intron-variant
rs1046908 -- 1,564,515(-) GGGTC(G/T)TGACA intron-variant, nc-transcript-variant
rs1887284 -- 1,551,679(-) GCGTC(C/T)GCGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSU72 Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv10n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
dgv33n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
nsv871837 CNV Loss 21882294
nsv871690 CNV Gain 21882294
essv5472 CNV CNV 17122850
dgv9e1 CNV Complex 17122850
dgv42n71 CNV Loss 21882294
dgv43n71 CNV Loss 21882294
dgv44n71 CNV Gain+Loss 21882294
nsv871954 CNV Loss 21882294
nsv871540 CNV Gain 21882294
dgv45n71 CNV Loss 21882294
esv1301718 CNV Insertion 17803354
esv2747918 CNV Deletion 23290073
esv2748029 CNV Deletion 23290073
esv2675022 CNV Deletion 23128226
esv1010850 CNV Insertion 20482838

Relevant External Links for SSU72 Gene

HapMap Linkage Disequilibrium report
SSU72

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSU72 Gene

Disorders for SSU72 Gene

Relevant External Links for SSU72

Genetic Association Database (GAD)
SSU72
Human Genome Epidemiology (HuGE) Navigator
SSU72
genes like me logo Genes that share disorders with SSU72: view

No data available for UniProtKB/Swiss-Prot for SSU72 Gene

Publications for SSU72 Gene

  1. Conserved and specific functions of mammalian ssu72. (PMID: 15659578) St Pierre B. … Zacksenhaus E. (Nucleic Acids Res. 2005) 2 3 4
  2. High resolution linkage and linkage disequilibrium analyses of chromosome 1p36 SNPs identify new positional candidate genes for low bone mineral density. (PMID: 18597038) Zhang H. … Devoto M. (Osteoporos Int 2009) 3 48
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Ssu72 Is an RNA polymerase II CTD phosphatase. (PMID: 15125841) Krishnamurthy S. … Hampsey M. (Mol. Cell 2004) 2 3

Products for SSU72 Gene

Sources for SSU72 Gene

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