Aliases for SSTR5 Gene
External Ids for SSTR5 Gene
Previous GeneCards Identifiers for SSTR5 Gene
Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.[provided by RefSeq, Feb 2010]
GeneCards Summary for SSTR5 Gene
SSTR5 (Somatostatin Receptor 5) is a Protein Coding gene. Diseases associated with SSTR5 include pituitary adenoma, growth hormone-secreting and pancreatic endocrine carcinoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include somatostatin receptor activity. An important paralog of this gene is GALR2.
UniProtKB/Swiss-Prot for SSTR5 Gene
Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits. alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments. The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane potential. S4 is also involved in channel gating.