Aliases for SSTR5 Gene
External Ids for SSTR5 Gene
Previous GeneCards Identifiers for SSTR5 Gene
Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.[provided by RefSeq, Feb 2010]
GeneCards Summary for SSTR5 Gene
SSTR5 (Somatostatin Receptor 5) is a Protein Coding gene. Diseases associated with SSTR5 include Pituitary Adenoma and Pituitary Adenoma, Prolactin-Secreting. Among its related pathways are Peptide ligand-binding receptors and cAMP signaling pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and somatostatin receptor activity. An important paralog of this gene is SSTR3.
UniProtKB/Swiss-Prot for SSTR5 Gene
Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.
Somatostatin (somatotropin release inhibiting factor, SRIF) is an endogenous cyclic polypeptide with two biologically active forms. It is an abundant neuropeptide and has a wide range of physiological effects on neurotransmission, secretion and cell proliferation.