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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SSTR5 Gene

protein-coding   GIFtS: 66
GCID: GC16P001122

somatostatin receptor 5

 Explore 45 diseases affiliated with
SSTR5 via our new
 Human Malady Compendium 
Biological research products
for SSTR5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Somatostatin Receptor 51 2
SS-5-R2 3
Somatostatin Receptor Subtype 52
Somatostatin Receptor Type 52
SS5-R3
SS5R3

External Ids:    HGNC: 113341   Entrez Gene: 67552   Ensembl: ENSG000001620097   OMIM: 1824555   UniProtKB: P353463   

Export aliases for SSTR5 gene to outside databases

Previous GC identifers: GC16P001143 GC16P001068


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SSTR5:
Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets
by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a
multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is
mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required
for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance.
Alternatively spliced transcript variants have been identified in this gene.(provided by RefSeq, Feb 2010)

UniProtKB/Swiss-Prot: SSR5_HUMAN, P35346
Function: Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is
mediated by G proteins which inhibit adenylyl cyclase

summary for SSTR5:
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in
excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low
levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are
composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits.
alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments.
The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane
potential. S4 is also involved in channel gating.

Gene Wiki entry for SSTR5 (Somatostatin receptor 5)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SSTR5 gene promoter:
         p53   Bach2   LCR-F1   C/EBPalpha   E47   CREB   ZID   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SSTR5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSTR5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

SSTR5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSTR5 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P001122:  view genomic region     (about GC identifiers)

Start:
1,122,756 bp from pter      End:
1,131,454 bp from pter
Size:
8,699 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SSR5_HUMAN, P35346 (See protein sequence)
Recommended Name: Somatostatin receptor type 5  
Size: 364 amino acids; 39202 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: P34988 Q541E0 Q9UJI5

Explore the universe of human proteins at neXtProt for SSTR5: NX_P35346

Post-translational modifications:

  • Palmitoylated by ZDHHC5, but not ZDHHC3, nor ZDHHC8. Palmitoylation creates an additional intracellular loop which is
  • thought to be important for efficient coupling to G-proteins and may target the protein to lipid rafts1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P35346

  • SSTR5 Protein expression data from MOPED and PaxDb:    About this image 
    SSTR5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001044.1  NP_001166031.1  

    ENSEMBL proteins: 
     ENSP00000454964   ENSP00000380680   ENSP00000293897  
    Reactome Protein details: P35346
    Human Recombinant Protein Products for SSTR5: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SSTR5

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7908405
    GO:0016021integral to membrane ----

    SSTR5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SSTR5


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SSTR5 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001184 Somatstn_rcpt_5
     IPR000586 Somatstn_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P35346

    ProtoNet protein and cluster: P35346

    2 Blocks protein families:
    IPB000586 Somatostatin receptor signature
    IPB001184 Somatostatin receptor type 5 signature


    UniProtKB/Swiss-Prot: SSR5_HUMAN, P35346
    Similarity: Belongs to the G-protein coupled receptor 1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSR5_HUMAN, P35346
    Function: Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is
    mediated by G proteins which inhibit adenylyl cyclase

         Genatlas biochemistry entry for SSTR5:
    somatostatin receptor gene 5,G protein coupled receptor superfamily

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004994somatostatin receptor activity IEA--
    GO:0005515protein binding ----
         
    SSTR5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SSTR5:
     Decreased influenza A/WSN/33 r 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Sstr5):
     endocrine/exocrine gland  growth/size  homeostasis/metabolism 

    SSTR5 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Sstr5tm1Fcb for SSTR5
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SSTR5 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSTR5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)1.00
    G alpha (i) signalling events0.44
    GPCR ligand binding0.75
    GPCRs, Class A Rhodopsin-like0.41
    Peptide ligand-binding receptors0.61
    Neuroactive ligand-receptor interaction0.38
    2Signaling by GPCR
    Signaling by GPCR1.00
    Signal Transduction0.56
    GPCR downstream signaling0.89
    3Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q1.00
    Peptide GPCRs0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SSTR5
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


    2 BioSystems Pathways for SSTR5 
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    5/7        Reactome Pathways for SSTR5 (see all 7)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events


    1         Kegg Pathway  (Kegg details for SSTR5):
        Neuroactive ligand-receptor interaction


    SSTR5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SSTR5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/151 Interacting proteins for SSTR5 (P353463 ENSP000002938974) via UniProtKB, MINT, STRING, and/or I2D (see all 151)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOPCQ9HD263, ENSP000003574844I2D: score=3 STRING: ENSP00000357484
    CORTO002303, ENSP000003662484I2D: score=1 STRING: ENSP00000366248
    SSTP612783, ENSP000002876414I2D: score=1 STRING: ENSP00000287641
    ADCY10Q96PN63, ENSP000003568254I2D: score=1 STRING: ENSP00000356825
    DRD2P144163, ENSP000003548594I2D: score=2 STRING: ENSP00000354859
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS9892014
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS7908405
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ----
    GO:0008285negative regulation of cell proliferation TAS9892014
    GO:0038170somatostatin signaling pathway TAS9892014

    SSTR5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SSTR5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SSTR5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Octreotide sst2, sst3 and sst5 agonist [79517-01-4]
    SomatostatinInfluences growth hormone release[51110-01-1]
    L-803,087 trifluoroacetate Potent and selective sst4 agonist[217480-26-7]
    RC 160Somatostatin analog[103222-11-3]
    CyclosomatostatinNon-selective sst receptor antagonist[84211-54-1]

    2 DrugBank Compounds for SSTR5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    OctreotideOctreotida [Spanish] (see all 3)83150-76-9target--16625841 16086874 16438887 16625842 16809928
    VapreotideBMY 41606 (see all 6)103222-11-3targetagonist19708854

    10/11 Novoseek chemical compound relationships for SSTR5 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lanreotide 88 9 18778119 (1), 11231991 (1), 15799207 (1), 15671091 (1) (see all 9)
    octreotide 86.7 31 20464704 (4), 11231991 (3), 17159301 (3), 15994755 (2) (see all 16)
    pasireotide 81.3 1 17395978 (1)
    111in-pentetreotide 63.9 2 16625862 (1), 19307732 (1)
    ribonucleic acid 48.7 4 10487698 (1), 10902809 (1), 11231991 (1), 7521350 (1)
    acth 29.5 2 15817922 (1), 15769796 (1)
    glyceraldehyde 3-phosphate 23.6 4 10487698 (1), 10690891 (1), 11231991 (1)
    dopamine 23.5 9 15994755 (2), 19003539 (2), 16216913 (1), 16625841 (1) (see all 6)
    thymidine 0 1 11344221 (1)
    calcium 0 2 7878022 (1), 8961277 (1)

    Search CenterWatch for drugs/clinical trials and news about SSTR5 / SSR5 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SSTR5 gene (4 alternative transcripts): 
    NM_001053.3  NM_001172560.1  NM_001172572.1  NM_001172573.1  

    Unigene Cluster for SSTR5:

    Somatostatin receptor 5
    Hs.449840  [show with all ESTs]
    Unigene Representative Sequence: NM_001053
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000562758 ENST00000397547(uc021taf.1) ENST00000293897(uc002ckq.3)


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    Additional cDNA sequence: 

    AK308381.1 DQ448303.1 DQ448304.1 

    3 DOTS entries:

    DT.91707440  DT.95189877  DT.75170796 

    14 AceView cDNA sequences:

    NM_001053 CN838037 CK825458 BM702398 AU279805 AI393288 CK825459 AJ706985 
    BQ270941 BQ271239 BF764911 BI765565 BG897323 CN837866 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SSTR5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGTTGGTGG
    SSTR5 Expression
    About this image
    See SSTR5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SSTR5

    SOURCE GeneReport for Unigene cluster: Hs.449840

    UniProtKB/Swiss-Prot: SSR5_HUMAN, P35346
    Tissue specificity: Adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus. No
    expression in fetal or adult kidney, liver, pancreas, uterus, spleen, lung, thyroid or ovary

        SABiosciences Expression via Pathway-Focused PCR Array including SSTR5: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSTR5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SSTR5 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SSTR51 somatostatin receptor 5 65.78(n)
    67.65(a)
      427667  NM_001024834.1  NP_001020005.1 
    lizard
    (Anolis carolinensis)
    Reptilia SSTR56
    --
    64(a)
    1 ↔ 1
    GL343263.1(1760857-1761951)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:856821 zgc:85682 63.06(n)
    60.19(a)
      406588  NM_213297.1  NP_998462.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Drostar13 G-protein coupled receptor protein signaling
    pathway somatostatin receptor less
    43(a)
    (best of 2)
      75D2   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y54E2A.16
    --
    12(a)
    possible ortholog
    II(14734335-14739167)


    ENSEMBL Gene Tree for SSTR5 (if available)
    TreeFam Gene Tree for SSTR5 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SSTR5 gene
    SSTR32  OPRD12  SSTR42  GALR22  MCHR22  SSTR12  GALR32  OPRL12  
    NPBWR12  OPRK12  KISS1R2  GALR12  SSTR22  MCHR12  NPBWR22  OPRM12  
    18/61 SIMAP similar genes for SSTR5 using alignment to 4 protein entries:     SSR5_HUMAN (see all proteins) (see all similar genes):
    SSTR2    SSTR4    SSTR3    SSTR1    CCR2    C3AR1
    CX3CR1    GHSR    HTR2B    OPRM1    CCR-5    CXCR2
    CCR7    OPRK1    CCR3    OPRD1    GPR141    GPR24

    SSTR5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/334 NCBI SNPs in SSTR5 are shown (see all 334    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219178771,2
    C,Fpathogenic1129586(+) TGCGGC/TGGCGC 5 R W us2k1 mis11Minor allele frequency- T:0.00NA 4230
    rs1926964771,2
    --1121008(+) TGGGTA/GGGACT 2 -- int1 us2k10--------
    rs1127364971,2
    F--1121175(+) TCCAGC/TGCCCA 2 -- int1 us2k12Minor allele frequency- T:0.50CSA 4
    rs5484111,2
    C,F,A,H--1121226(+) GACTCG/TCACAC 2 -- us2k1 int123Minor allele frequency- T:0.22NA NS EA WA CSA 2472
    rs1880057721,2
    --1121247(+) ACCCCC/TGGGGC 2 -- int1 us2k10--------
    rs1921900131,2
    --1121317(+) CAGATA/GGGGGC 2 -- us2k1 int10--------
    rs1141712031,2
    F--1121331(+) GGTGCG/TAGGCA 2 -- int1 us2k11Minor allele frequency- T:0.03WA 118
    rs713802311,2
    C,F--1121371(+) TGAGGC/TGAGAA 2 -- us2k1 int13Minor allele frequency- T:0.08NA 124
    rs1154329051,2
    C,F--1121428(+) GATGGG/AGGAGG 2 -- int1 us2k11Minor allele frequency- A:0.37WA 118
    rs5797971,2
    C,F,A--1121434(+) GGAGGC/AGTTAG 2 -- us2k1 int17Minor allele frequency- A:0.41EA NA CSA WA 542

    HapMap Linkage Disequilibrium report for SSTR5 (1122756 - 1131454 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for SSTR5
         9 CNVs: 29655 29991 29989 29994 3987 29990 5329 29653 29993
    Human Gene Mutation Database (HGMD): SSTR5

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SSTR5 for disorders           About GeneDecksing

    OMIM gene information: 182455   
    OMIM disorders: 102200  
    20/45 diseases for SSTR5 (see all 45):    About MalaCards
    somatostatin analog, resistance to    growth hormone secreting pituitary adenoma    oncogenic osteomalacia    pituitary adenoma
    functioning pituitary adenoma    bipolar affective disorder    glucagonoma    osteomalacia
    anorexia nervosa    prolactinoma    fetal adenoma    pancreatic endocrine tumors
    adenoma    pancreatic endocrine carcinoma    pituitary tumor    acromegaly
    atopic dermatitis    insulinoma    carcinoid tumors    cushing's syndrome

    3 diseases from the University of Copenhagen DISEASES database for SSTR5:
    Adenoma     Acromegaly     Pituitary adenoma

    10/19 Novoseek disease relationships for SSTR5 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pituitary adenoma 80.2 12 11399907 (1), 20464704 (1), 16216913 (1), 10100234 (1) (see all 11)
    prolactinoma 79.4 15 10487698 (2), 7521350 (2), 16595604 (1), 7908405 (1) (see all 9)
    acromegaly 73.2 6 15914528 (1), 11399907 (1), 11081177 (1), 19533047 (1) (see all 6)
    pituitary tumors 70.9 5 7908405 (2), 9709982 (1), 7521350 (1), 19401364 (1)
    adenoma 66.8 46 11399907 (4), 14661732 (4), 11231991 (3), 11264647 (2) (see all 19)
    pituitary adenoma nonfunctioning 65.4 3 15472224 (1)
    insulinoma 60.3 7 16601280 (3), 12021920 (1), 7908405 (1), 16263117 (1)
    glucagonoma 57.2 2 8132773 (1), 12021920 (1)
    gastrinoma 54.7 1 12021920 (1)
    carcinoid 48.3 1 16508627 (1)

    Genetic Association Database (GAD): SSTR5
    Human Genome Epidemiology (HuGE) Navigator: SSTR5 (13 documents)

    Export disorders for SSTR5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SSTR5 gene, integrated from 9 sources (see all 196):
    (articles sorted by number of sources associating them with SSTR5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel polymorphisms in the somatostatin receptor 5 (SSTR5) gene associated with bipolar affective disorder. (PubMed id 12192619)1, 4, 9 Nyegaard M....Kruse T.A. (2002)
    2. Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28. (PubMed id 7908405)1, 2, 9 Panetta R.... Patel Y.C. (1994)
    3. Analysis of somatostatin receptors 2 and 5 polymorphisms in patients with acromegaly. (PubMed id 15914528)1, 4, 9 Filopanti M....Spada A. (2005)
    4. Localization of human somatostatin receptor 5 gene (SSTR5) to chromosome band 16p13.3 by fluorescence in situ hybridization. (PubMed id 7607700)1, 3, 9 Takeda J....Bell G.I. (1995)
    5. Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase. (PubMed id 21820437)1, 2 Kokkola T.... Kreienkamp H.J. (2011)
    6. Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nutrition study. (PubMed id 16214911)1, 4 Canzian F....Kaaks R. (2005)
    7. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
    8. Identification of an upstream pituitary-active promoter of human somatostatin receptor subtype 5. (PubMed id 12072395)1, 2 Petersenn S.... Schulte H.M. (2002)
    9. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (2001)
    10. Characterization of cloned human somatostatin receptor SSTR5. (PubMed id 8078491)1, 2 O'Carroll A.-M.... Reisine T. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6755 HGNC: 11334 AceView: SSTR5 Ensembl:ENSG00000162009 euGenes: HUgn6755
    ECgene: SSTR5 Kegg: 6755 H-InvDB: SSTR5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SSTR5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SSTR5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SSTR5 gene:
    Search GeneIP for patents involving SSTR5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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